Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Sulfones"" wg kryterium: Temat


Tytuł :
The ALK inhibitors, alectinib and ceritinib, induce ALK-independent and STAT3-dependent glioblastoma cell death.
Autorzy :
Kawauchi D; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.; Department of Neurological Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Takahashi M; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.; Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.
Satomi K; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.
Yamamuro S; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.; Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan.
Kobayashi T; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.; Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.
Uchida E; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.; Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka-City, Japan.
Honda-Kitahara M; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.
Narita Y; Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.
Iwadate Y; Department of Neurological Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Ichimura K; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.
Tomiyama A; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.; Department of Neurosurgery, National Defense Medical College, Tokorozawa, Japan.
Pokaż więcej
Źródło :
Cancer science [Cancer Sci] 2021 Jun; Vol. 112 (6), pp. 2442-2453. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article
MeSH Terms :
Anaplastic Lymphoma Kinase/*genetics
Brain Neoplasms/*drug therapy
Carbazoles/*administration & dosage
Glioblastoma/*drug therapy
Piperidines/*administration & dosage
Pyrimidines/*administration & dosage
STAT3 Transcription Factor/*metabolism
Sulfones/*administration & dosage
Administration, Oral ; Anaplastic Lymphoma Kinase/metabolism ; Animals ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Carbazoles/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Resistance, Neoplasm/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Humans ; Mice ; Piperidines/pharmacology ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/pharmacology ; Pyrimidines/pharmacology ; Signal Transduction/drug effects ; Sulfones/pharmacology ; Temozolomide/pharmacology ; Treatment Outcome ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Tumor-associated macrophages-mediated CXCL8 infiltration enhances breast cancer metastasis: Suppression by Danirixin.
Autorzy :
Nie G; Department of Breast Center, The Affiliated Hospital of Qingdao University, Shandong 266000, China.
Cao X; The Affiliated Hospital of Qingdao University, Library, Shandong 266000, China.
Mao Y; Department of Breast Center, The Affiliated Hospital of Qingdao University, Shandong 266000, China.
Lv Z; Department of Breast Center, The Affiliated Hospital of Qingdao University, Shandong 266000, China.
Lv M; Department of Breast Center, The Affiliated Hospital of Qingdao University, Shandong 266000, China.
Wang Y; Department of Breast Center, The Affiliated Hospital of Qingdao University, Shandong 266000, China.
Wang H; Department of Breast Center, The Affiliated Hospital of Qingdao University, Shandong 266000, China.
Liu C; Department of Breast Center, The Affiliated Hospital of Qingdao University, Shandong 266000, China. Electronic address: .
Pokaż więcej
Źródło :
International immunopharmacology [Int Immunopharmacol] 2021 Jun; Vol. 95, pp. 107153. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Breast Neoplasms/*drug therapy
Interleukin-8/*immunology
Piperidines/*therapeutic use
Sulfones/*therapeutic use
Tumor-Associated Macrophages/*immunology
Animals ; Antineoplastic Agents/pharmacology ; Breast Neoplasms/blood ; Breast Neoplasms/immunology ; Breast Neoplasms/pathology ; Cell Line ; Cell Movement/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Female ; Humans ; Interleukin-8/blood ; Mice, Inbred BALB C ; Mice, Nude ; Neoplastic Stem Cells/drug effects ; Piperidines/pharmacology ; Sulfones/pharmacology
Czasopismo naukowe
Tytuł :
Ocular lichen planus treated with lifitegrast.
Autorzy :
Lee EY; Department of Bioengineering, UCLA, Los Angeles, CA, USA.; Division of Dermatology, Department of Medicine, UCLA, Los Angeles, CA, USA.; UCLA-Caltech Medical Scientist Training Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Arzeno J; Division of Dermatology, Department of Medicine, UCLA, Los Angeles, CA, USA.
Ni C; Division of Dermatology, Department of Medicine, UCLA, Los Angeles, CA, USA.
Holland V; Division of Dermatology, Department of Medicine, UCLA, Los Angeles, CA, USA.
Pokaż więcej
Źródło :
International journal of dermatology [Int J Dermatol] 2021 Jun; Vol. 60 (6), pp. e231-e233. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Letter
MeSH Terms :
Lichen Planus*/diagnosis
Lichen Planus*/drug therapy
Sulfones*
Eye ; Humans ; Phenylalanine/analogs & derivatives
Opinia redakcyjna
Tytuł :
Identification of Vinyl Sulfone Derivatives as EGFR Tyrosine Kinase Inhibitor: In Vitro and In Silico Studies.
Autorzy :
Aiebchun T; Biocatalyst and Environmental Biotechnology Research Unit, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Mahalapbutr P; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Auepattanapong A; Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Bangkok 10700, Thailand.
Khaikate O; Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Bangkok 10700, Thailand.
Seetaha S; Department of Biochemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.
Tabtimmai L; Department of Biotechnology, Faculty of Applied Science, King Mongkut's University of Technology of North Bangkok, Bangkok 10800, Thailand.
Kuhakarn C; Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Bangkok 10700, Thailand.
Choowongkomon K; Department of Biochemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.
Rungrotmongkol T; Biocatalyst and Environmental Biotechnology Research Unit, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.; Program in Bioinformatics and Computational Biology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Pokaż więcej
Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 12; Vol. 26 (8). Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
Computer Simulation*
ErbB Receptors/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Sulfones/*pharmacology
Cell Death/drug effects ; Cell Line, Tumor ; ErbB Receptors/metabolism ; Erlotinib Hydrochloride/chemistry ; Erlotinib Hydrochloride/pharmacology ; Humans ; Hydrogen Bonding ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Kinase Inhibitors/chemistry ; Sulfones/chemistry ; Thermodynamics
Czasopismo naukowe
Tytuł :
Development and optimization of halogenated vinyl sulfones as Nrf2 activators for the treatment of Parkinson's disease.
Autorzy :
Choi JW; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
Kim S; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, Republic of Korea.
Yoo JS; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, Republic of Korea.
Kim HJ; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Department of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
Kim HJ; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
Kim BE; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Department of Fundamental Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea.
Lee EH; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, Republic of Korea.
Lee YS; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, Republic of Korea; Department of Fundamental Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea. Electronic address: .
Park JH; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea. Electronic address: .
Park KD; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, Republic of Korea; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, Republic of Korea. Electronic address: .
Pokaż więcej
Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Feb 15; Vol. 212, pp. 113103. Date of Electronic Publication: 2020 Dec 25.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Development*
NF-E2-Related Factor 2/*metabolism
Parkinson Disease/*drug therapy
Sulfones/*pharmacology
Animals ; Cell Line ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Halogenation ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Parkinson Disease/metabolism ; Structure-Activity Relationship ; Sulfones/chemical synthesis ; Sulfones/chemistry
Czasopismo naukowe
Tytuł :
Discovery of a PROTAC targeting ALK with in vivo activity.
Autorzy :
Yan G; State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Chengdu, China; Department of Hepatobiliary Pancreatic Surgery, Henan Provincial People's Hospital, Henan University, Zhengzhou, China.
Zhong X; State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Chengdu, China.
Yue L; State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Chengdu, China.
Pu C; State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Chengdu, China.
Shan H; State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Chengdu, China.
Lan S; State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Chengdu, China.
Zhou M; Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Ministry of Education & State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.
Hou X; College of Pharmacy, Xinxiang Medical University, Xinxiang, China.
Yang J; State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Chengdu, China.
Li R; State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Chengdu, China. Electronic address: .
Pokaż więcej
Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Feb 15; Vol. 212, pp. 113150. Date of Electronic Publication: 2021 Jan 02.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Anaplastic Lymphoma Kinase/*antagonists & inhibitors
Antineoplastic Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Pyrimidines/*pharmacology
Sulfones/*pharmacology
Anaplastic Lymphoma Kinase/metabolism ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Humans ; Ligands ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Sulfones/chemical synthesis ; Sulfones/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Cardioprotective Effects of a Nonsteroidal Mineralocorticoid Receptor Blocker, Esaxerenone, in Dahl Salt-Sensitive Hypertensive Rats.
Autorzy :
Rahman A; Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Sawano T; Division of Pharmacology, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.
Sen A; Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Hossain A; Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Jahan N; Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Kobara H; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Masaki T; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Kosaka S; Department of Pharmacy, Kagawa University Hospital, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Kitada K; Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Nakano D; Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Imamura T; Division of Pharmacology, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.
Ohsaki H; Department of Medical Biophysics, Kobe University Graduate School of Health Sciences, 7-10-2, Tomogaoka, Suma-ku, Kobe, Hyogo 654-0142, Japan.
Nishiyama A; Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 19; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Cardiotonic Agents/*therapeutic use
Hypertension/*drug therapy
Mineralocorticoid Receptor Antagonists/*therapeutic use
Pyrroles/*therapeutic use
Receptors, Mineralocorticoid/*metabolism
Sulfones/*therapeutic use
Animals ; Cardiotonic Agents/pharmacology ; Electrocardiography ; Fibrosis ; Hypertension/diagnostic imaging ; Hypertension/physiopathology ; Inflammation/complications ; Inflammation/drug therapy ; Male ; Pyrroles/pharmacology ; Rats, Inbred Dahl ; Sodium Chloride, Dietary ; Sulfones/pharmacology ; Survival Analysis ; Ventricular Remodeling/drug effects
Czasopismo naukowe
Tytuł :
Exposure to alternative bisphenols BPS and BPF through breast milk: Noxious heritage effect during nursing associated with idiopathic infertility.
Autorzy :
Nevoral J; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic; Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic. Electronic address: .
Havránková J; Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
Kolinko Y; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic; Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
Prokešová Š; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic; Institute of Animal Science, Prague 10-Uhrineves, Czech Republic.
Fenclová T; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
Monsef L; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
Žalmanová T; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic; Institute of Animal Science, Prague 10-Uhrineves, Czech Republic.
Petr J; Institute of Animal Science, Prague 10-Uhrineves, Czech Republic.
Králíčková M; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic; Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
Pokaż więcej
Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Feb 15; Vol. 413, pp. 115409. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzhydryl Compounds/*toxicity
Fertility/*drug effects
Infertility, Female/*chemically induced
Lactation/*metabolism
Milk/*metabolism
Oocytes/*drug effects
Ovary/*drug effects
Phenols/*toxicity
Sulfones/*toxicity
Animals ; Animals, Suckling ; Benzhydryl Compounds/metabolism ; Epigenesis, Genetic ; Female ; Gene Expression Regulation, Developmental ; In Vitro Oocyte Maturation Techniques ; Infertility, Female/metabolism ; Infertility, Female/pathology ; Infertility, Female/physiopathology ; Maternal Exposure ; Mice, Inbred ICR ; Oocytes/metabolism ; Oocytes/pathology ; Ovarian Reserve/drug effects ; Ovary/metabolism ; Ovary/physiopathology ; Phenols/metabolism ; Pregnancy ; Risk Assessment ; Spindle Apparatus/drug effects ; Spindle Apparatus/metabolism ; Spindle Apparatus/pathology ; Sulfones/metabolism
Czasopismo naukowe
Tytuł :
Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir.
Autorzy :
Bai Y; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Ye F; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, 102206, China.
Feng Y; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Liao H; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Song H; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China.
Qi J; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Gao GF; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.; Center for Influenza Research and Early Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Disease (CEEID), Chinese Academy of Sciences, Beijing, 100101, China.
Tan W; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China. .
Fu L; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. .; Center for Influenza Research and Early Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Disease (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. .
Shi Y; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China. .; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. .; Center for Influenza Research and Early Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Disease (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. .
Pokaż więcej
Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2021 Feb 04; Vol. 6 (1), pp. 51. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus 3C Proteases*/antagonists & inhibitors
Coronavirus 3C Proteases*/chemistry
COVID-19/*enzymology
Cyclopropanes/*chemistry
Cysteine Proteinase Inhibitors/*chemistry
Leucine/*analogs & derivatives
Proline/*analogs & derivatives
SARS-CoV-2/*enzymology
Sulfones/*chemistry
Urea/*chemistry
COVID-19/drug therapy ; Cyclopropanes/pharmacology ; Cysteine Proteinase Inhibitors/pharmacology ; Hepacivirus/enzymology ; Humans ; Leucine/chemistry ; Leucine/pharmacology ; Proline/chemistry ; Proline/pharmacology ; Sulfones/pharmacology ; Urea/pharmacology
Raport
Tytuł :
Comparative toxicokinetics of bisphenol S and bisphenol AF in male rats and mice following repeated exposure via feed.
Autorzy :
Waidyanatha S; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Black SR; Discovery Sciences, RTI International, Research Triangle Park, NC, USA.
Croutch CR; MRIGlobal, Kansas City, MO, USA.
Collins BJ; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Silinski MAR; Discovery Sciences, RTI International, Research Triangle Park, NC, USA.
Kerns S; MRIGlobal, Kansas City, MO, USA.
Sutherland V; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Robinson VG; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Aillon K; MRIGlobal, Kansas City, MO, USA.
Fernando RA; Discovery Sciences, RTI International, Research Triangle Park, NC, USA.
Mutlu E; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Fennell TR; Discovery Sciences, RTI International, Research Triangle Park, NC, USA.
Pokaż więcej
Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Feb; Vol. 51 (2), pp. 210-221. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Benzhydryl Compounds/*pharmacokinetics
Hazardous Substances/*pharmacokinetics
Phenols/*pharmacokinetics
Sulfones/*pharmacokinetics
Animals ; Benzhydryl Compounds/toxicity ; Hazardous Substances/toxicity ; Kinetics ; Male ; Mice ; Phenols/toxicity ; Rats ; Sulfones/toxicity ; Toxicity Tests ; Toxicokinetics
Czasopismo naukowe
Tytuł :
The occurrence of bisphenol compounds in animal feed plastic packaging and migration into feed.
Autorzy :
Wang R; Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, 10081, China. Electronic address: .
Huang Y; Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, 10081, China. Electronic address: .
Dong S; Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, 10081, China. Electronic address: .
Wang P; Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, 10081, China. Electronic address: .
Su X; Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, 10081, China. Electronic address: .
Pokaż więcej
Źródło :
Chemosphere [Chemosphere] 2021 Feb; Vol. 265, pp. 129022. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
Plastics*
Sulfones*
Animal Feed ; Animals ; Benzhydryl Compounds/analysis ; Humans ; Phenols
Czasopismo naukowe
Tytuł :
Associations Between Thyroid Hormone Levels and Urinary Concentrations of Bisphenol A, F, and S in 6-Year-old Children in Korea.
Autorzy :
Jang Y; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.; Environmental Health Center, Seoul National University College of Medicine, Seoul, Korea.
Choi YJ; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.; Environmental Health Center, Seoul National University College of Medicine, Seoul, Korea.
Lim YH; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea.; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Lee KS; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.; Environmental Health Center, Seoul National University College of Medicine, Seoul, Korea.
Kim BN; Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
Shin CH; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
Lee YA; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
Kim JI; Department of Psychiatry, Hanyang University Medical Center, Seoul, Korea.
Hong YC; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.; Environmental Health Center, Seoul National University College of Medicine, Seoul, Korea.; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea.
Pokaż więcej
Źródło :
Journal of preventive medicine and public health = Yebang Uihakhoe chi [J Prev Med Public Health] 2021 Jan; Vol. 54 (1), pp. 37-45. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article
MeSH Terms :
Benzhydryl Compounds/*analysis
Phenols/*analysis
Sulfones/*analysis
Thyroid Hormones/*analysis
Benzhydryl Compounds/urine ; Child ; Cohort Studies ; Female ; Humans ; Male ; Phenols/urine ; Prospective Studies ; Republic of Korea ; Sulfones/urine ; Thyroid Hormones/blood
Czasopismo naukowe
Tytuł :
A phase 2a, randomized, double-blind, placebo-controlled trial of the efficacy and safety of the oral gonadotropin-releasing hormone antagonist, ASP1707, in postmenopausal female patients with rheumatoid arthritis taking methotrexate.
Autorzy :
Takeuchi T; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Tanaka Y; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Higashitani C; Clinical Development, Astellas Pharma, Inc., Tokyo, Japan.
Iwai M; Clinical Pharmacology and Exploratory Development, Astellas Pharma, Inc., Tokyo, Japan.
Komatsu K; Clinical Pharmacology, Astellas Pharma, Inc., Tokyo, Japan.
Akazawa R; Data Science, Astellas Pharma, Inc., Tokyo, Japan.
Lademacher C; Medical Science, Astellas Pharma, Inc., Northbrook, IL, USA.
Pokaż więcej
Źródło :
Modern rheumatology [Mod Rheumatol] 2021 Jan; Vol. 31 (1), pp. 53-60. Date of Electronic Publication: 2020 Mar 03.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
MeSH Terms :
Postmenopause*
Antirheumatic Agents/*therapeutic use
Arthritis, Rheumatoid/*drug therapy
Gonadotropin-Releasing Hormone/*antagonists & inhibitors
Imidazoles/*therapeutic use
Methotrexate/*therapeutic use
Sulfones/*therapeutic use
Aged ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Humans ; Imidazoles/adverse effects ; Middle Aged ; Sulfones/adverse effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Induced Production, Synthesis, and Immunomodulatory Action of Clostrisulfone, a Diarylsulfone from Clostridium acetobutylicum.
Autorzy :
Neuwirth T; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Chemistry and Infection Biology (HKI), Beutenbergstr. 11a, 07745, Jena, Germany.
Letzel AC; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Chemistry and Infection Biology (HKI), Beutenbergstr. 11a, 07745, Jena, Germany.
Tank C; BioPilotPlant, Leibniz Institute for Natural Product Chemistry and Infection Biology (HKI), Beutenbergstr. 11a, 07745, Jena, Germany.
Ishida K; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Chemistry and Infection Biology (HKI), Beutenbergstr. 11a, 07745, Jena, Germany.
Cyrulies M; BioPilotPlant, Leibniz Institute for Natural Product Chemistry and Infection Biology (HKI), Beutenbergstr. 11a, 07745, Jena, Germany.
Schmölz L; Institute of Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Straße 25, 07743, Jena, Germany.
Lorkowski S; Institute of Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Straße 25, 07743, Jena, Germany.
Hertweck C; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Chemistry and Infection Biology (HKI), Beutenbergstr. 11a, 07745, Jena, Germany.; Faculty of Biological Sciences, Friedrich Schiller University Jena, 07743, Jena, Germany.
Pokaż więcej
Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Dec 04; Vol. 26 (68), pp. 15855-15858. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :
Journal Article
MeSH Terms :
Clostridium acetobutylicum*/chemistry
Clostridium acetobutylicum*/drug effects
Clostridium acetobutylicum*/genetics
Clostridium acetobutylicum*/metabolism
Immunologic Factors*/metabolism
Immunologic Factors*/pharmacology
Sulfones*/metabolism
Sulfones*/pharmacology
Animals ; Cysteine/pharmacology ; Macrophages/drug effects ; Mice ; Multigene Family
Czasopismo naukowe
Tytuł :
Antibacterial activities of sulfonyl or sulfonamide containing heterocyclic derivatives and its structure-activity relationships (SAR) studies: A critical review.
Autorzy :
Kumar Verma S; School of Chemistry and Chemical Engineering, Yulin University, Yulin 719000, Shaanxi, PR China; Shaanxi Key Laboratory of Low Metamorphic Coal Clean Utilization, Yulin University, Yulin 719000, Shaanxi, PR China.
Verma R; School of Chemistry and Chemical Engineering, Yulin University, Yulin 719000, Shaanxi, PR China; Shaanxi Key Laboratory of Low Metamorphic Coal Clean Utilization, Yulin University, Yulin 719000, Shaanxi, PR China. Electronic address: .
Xue F; School of Chemistry and Chemical Engineering, Yulin University, Yulin 719000, Shaanxi, PR China.
Kumar Thakur P; School of Sciences, MATS University, Raipur 492004, Chhattisgarh, India.
Girish YR; ACU-Centre for Research and Innovations, School of Natural Sciences, Adichunchanagiri University, B.G. Nagara, Mandya 571448, India.
Rakesh KP; Department of Chemistry, School of Material Science and Engineering, Wuhan Institute of Technology, Wuhan 430073, PR China. Electronic address: .
Pokaż więcej
Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Dec; Vol. 105, pp. 104400. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Gram-Negative Bacteria/*drug effects
Gram-Positive Bacteria/*drug effects
Heterocyclic Compounds/*pharmacology
Sulfonamides/*pharmacology
Sulfones/*pharmacology
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Heterocyclic Compounds/chemistry ; Microbial Sensitivity Tests ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry ; Sulfones/chemical synthesis ; Sulfones/chemistry
Czasopismo naukowe
Tytuł :
Comparative toxicokinetics of bisphenol S in rats and mice following gavage administration.
Autorzy :
Waidyanatha S; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Electronic address: .
Black SR; RTI International, Discovery Sciences, Research Triangle Park, NC, USA.
Silinski M; RTI International, Discovery Sciences, Research Triangle Park, NC, USA.
Sutherland V; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Fletcher BL; RTI International, Discovery Sciences, Research Triangle Park, NC, USA.
Fernando RA; RTI International, Discovery Sciences, Research Triangle Park, NC, USA.
Fennell TR; RTI International, Discovery Sciences, Research Triangle Park, NC, USA.
Pokaż więcej
Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Nov 01; Vol. 406, pp. 115207. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Phenols/*pharmacokinetics
Sulfones/*pharmacokinetics
Administration, Intravenous ; Administration, Oral ; Animals ; Biological Availability ; Female ; Male ; Mice ; Phenols/administration & dosage ; Phenols/blood ; Phenols/toxicity ; Rats ; Sex Characteristics ; Sulfones/administration & dosage ; Sulfones/blood ; Sulfones/toxicity
Czasopismo naukowe
Tytuł :
Anti-hypertrophic effect of Na exchanger-1 inhibition is mediated by reduced cathepsin B.
Autorzy :
Riaz S; College of Pharmacy, QU Health, Qatar University, Doha, Qatar; Hamad Medical Corporation, Doha, Qatar.
Abdulrahman N; College of Pharmacy, QU Health, Qatar University, Doha, Qatar; Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
Uddin S; Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
Jabeen A; College of Pharmacy, QU Health, Qatar University, Doha, Qatar.
Gadeau AP; University of Bordeaux, UMR1034, Pessac, France.
Fliegel L; University of Alberta, Edmonton, Alberta, Canada.
Mraiche F; College of Pharmacy, QU Health, Qatar University, Doha, Qatar. Electronic address: .
Pokaż więcej
Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 Dec 05; Vol. 888, pp. 173420. Date of Electronic Publication: 2020 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
Cathepsin B/*antagonists & inhibitors
Cathepsin B/*metabolism
Guanidines/*pharmacology
Myocytes, Cardiac/*metabolism
Sodium-Hydrogen Exchanger 1/*antagonists & inhibitors
Sodium-Hydrogen Exchanger 1/*metabolism
Sulfones/*pharmacology
Animals ; Cardiomegaly/drug therapy ; Cardiomegaly/metabolism ; Cardiomegaly/pathology ; Cell Line ; Dipeptides/pharmacology ; Dipeptides/therapeutic use ; Guanidines/therapeutic use ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/pathology ; Rats ; Sulfones/therapeutic use
Czasopismo naukowe
Tytuł :
Pharmacokinetics of carprofen and firocoxib for medication control in racing greyhounds.
Autorzy :
Morris TH; School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.; Greyhound Board of Great Britain, London, UK.
Paine SW; School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.
Zahra PW; Racing Analytical Services Limited, Flemington, Victoria, Australia.
Li EC; Racing Analytical Services Limited, Flemington, Victoria, Australia.; Agilent Technologies Australia, Mulgrave, Victoria, Australia.
Colgan SA; SCEC Eurofins, Northbridge, New South Wales, Australia.
Karamatic SL; Greyhound Racing Victoria, West Melbourne, Victoria, Australia.
Pokaż więcej
Źródło :
Australian veterinary journal [Aust Vet J] 2020 Dec; Vol. 98 (12), pp. 578-585. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article
MeSH Terms :
4-Butyrolactone*/analogs & derivatives
Sulfones*
Animals ; Carbazoles ; Dogs
Czasopismo naukowe
Tytuł :
Polyethersulfone membrane embedded with amine functionalized microcrystalline cellulose.
Autorzy :
Rafieian F; Department of the Built Environment, Eindhoven University of Technology, Eindhoven, the Netherlands. Electronic address: .
Mousavi M; Department of Food Science and Technology, Agricultural College, University of Tehran, Karaj, Iran.
Dufresne A; University Grenoble Alpes, CNRS, Grenoble INP, LGP2, F-38000 Grenoble, France.
Yu Q; Department of the Built Environment, Eindhoven University of Technology, Eindhoven, the Netherlands.
Pokaż więcej
Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Dec 01; Vol. 164, pp. 4444-4454. Date of Electronic Publication: 2020 Sep 05.
Typ publikacji :
Journal Article
MeSH Terms :
Cellulose*
Membranes, Artificial*
Polymers*
Sulfones*
Calorimetry, Differential Scanning ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Materials Testing ; Metformin/pharmacology ; Microscopy, Atomic Force ; Microscopy, Electron, Scanning ; Porosity ; Spectroscopy, Fourier Transform Infrared ; Surface Properties ; Tensile Strength ; Thermogravimetry
Czasopismo naukowe
Tytuł :
Effects of methylsulfonylmethane and neutralizing anti-IL-10 antibody supplementation during a mild Eimeria challenge infection in broiler chickens.
Autorzy :
Rasheed MSA; Department of Animal Sciences, University of Illinois, Urbana, USA 61801.
Tiwari UP; Department of Animal Sciences, University of Illinois, Urbana, USA 61801.
Jespersen JC; Department of Animal Sciences, University of Illinois, Urbana, USA 61801.
Bauer LL; Department of Animal Sciences, University of Illinois, Urbana, USA 61801.
Dilger RN; Department of Animal Sciences, University of Illinois, Urbana, USA 61801. Electronic address: .
Pokaż więcej
Źródło :
Poultry science [Poult Sci] 2020 Dec; Vol. 99 (12), pp. 6559-6568. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Journal Article
MeSH Terms :
Coccidiosis*/prevention & control
Coccidiosis*/therapy
Coccidiosis*/veterinary
Dietary Supplements*
Dimethyl Sulfoxide*/pharmacology
Eimeria tenella*
Interleukin-10*/pharmacology
Poultry Diseases*/prevention & control
Poultry Diseases*/therapy
Sulfones*/pharmacology
Animals ; Chickens ; Diet/veterinary ; Eimeria ; Male
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies