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Tytuł:
Cuproptosis related gene PDHB is identified as a biomarker inversely associated with the progression of clear cell renal cell carcinoma.
Autorzy:
Wang H; Department of Urology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.
Yang Z; Department of Urology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.
He X; Department of Urology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.
Guo F; Department of Urology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.
Sun H; Department of Urology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.
Xu S; Department of Urology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.
Xu C; Department of Urology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.
Wang Z; Department of Urology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.
Wen H; Department of Urology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.
Teng Z; Department of Urology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.
Wang Y; Department of Urology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China. .
Han Z; Department of Urology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China. .
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Źródło:
BMC cancer [BMC Cancer] 2023 Aug 28; Vol. 23 (1), pp. 804. Date of Electronic Publication: 2023 Aug 28.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma*
Carcinoma, Renal Cell*/genetics
Kidney Neoplasms*/genetics
Apoptosis*
Humans ; Biomarkers ; Copper
Czasopismo naukowe
Tytuł:
ENO1 expression and Erk phosphorylation in PDAC and their effects on tumor cell apoptosis in a hypoxic microenvironment.
Autorzy:
Sun H; Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Mo J; Department of Pathology, Tianjin Medical University, Tianjin 300070, China.
Cheng R; Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Li F; Department of Pathology, Tianjin Medical University, Tianjin 300070, China.
Li Y; Department of Pathology, Tianjin Medical University, Tianjin 300070, China.
Guo Y; Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Li Y; Department of Pathology, Tianjin Medical University, Tianjin 300070, China.
Zhang Y; Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Bai X; Department of Pathology, Tianjin Medical University, Tianjin 300070, China.
Wang Y; Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Dong X; Department of Pathology, Tianjin Medical University, Tianjin 300070, China.
Zhang D; Department of Pathology, Tianjin Medical University, Tianjin 300070, China.
Hao J; Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
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Źródło:
Cancer biology & medicine [Cancer Biol Med] 2022 Dec 05; Vol. 19 (11).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hypoxia*
Apoptosis*
Animals ; Mice
Czasopismo naukowe
Tytuł:
Protective Effect of Low-Dose Alcohol Consumption against Post-Ischemic Neuronal Apoptosis: Role of L-PGDS.
Autorzy:
Li C; Department of Cellular Biology & Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71103, USA.
Li J; Department of Cellular Biology & Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71103, USA.
Loreno EG; Department of Cellular Biology & Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71103, USA.
Miriyala S; Department of Cellular Biology & Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71103, USA.
Panchatcharam M; Department of Cellular Biology & Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71103, USA.
Sun H; Department of Cellular Biology & Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71103, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 23; Vol. 23 (1). Date of Electronic Publication: 2021 Dec 23.
Typ publikacji:
Journal Article
MeSH Terms:
Alcohol Drinking/*metabolism
Apoptosis/*drug effects
Brain Ischemia/*drug therapy
Ethanol/*administration & dosage
Intramolecular Oxidoreductases/*metabolism
Lipocalins/*metabolism
Neurons/*drug effects
Animals ; Brain Ischemia/metabolism ; Caspase 3/metabolism ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; Disease Models, Animal ; Infarction, Middle Cerebral Artery/drug therapy ; Infarction, Middle Cerebral Artery/metabolism ; Ischemic Attack, Transient/drug therapy ; Ischemic Attack, Transient/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/metabolism ; Neuroprotective Agents/administration & dosage ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism
Czasopismo naukowe
Tytuł:
Oxaliplatin promotes siMAD2L2‑induced apoptosis in colon cancer cells.
Autorzy:
Ma L; Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Li X; Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Zhao X; Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Sun H; Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Kong F; Department of Oncology, Qufu People's Hospital, Qufu, Shandong 273100, P.R. China.
Li Y; Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Sui Y; Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
Xu F; Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2021 Sep; Vol. 24 (3). Date of Electronic Publication: 2021 Jul 19.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Colonic Neoplasms/*drug therapy
Colorectal Neoplasms/*drug therapy
Mad2 Proteins/*metabolism
Oxaliplatin/*pharmacology
Cell Death/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Colonic Neoplasms/pathology ; Colorectal Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Mad2 Proteins/genetics ; Proteasome Endopeptidase Complex ; Proto-Oncogene Proteins c-bcl-2
Czasopismo naukowe
Tytuł:
Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate glucocorticoid-induced osteonecrosis of the femoral head.
Autorzy:
Yang N; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Sun H; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Xue Y; Department of Orthopaedics, Changshu Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Changshu, China.
Zhang W; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Wang H; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Tao H; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Liang X; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Li M; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Xu Y; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Chen L; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Zhang L; Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Huang L; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Geng D; Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2021 Jun; Vol. 11 (6), pp. e447.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Femur Head/*drug effects
Glucocorticoids/*toxicity
Kelch-Like ECH-Associated Protein 1/*metabolism
Monoacylglycerol Lipases/*antagonists & inhibitors
NF-E2-Related Factor 2/*metabolism
Osteonecrosis/*prevention & control
Animals ; Cell Differentiation ; Femur Head/pathology ; Kelch-Like ECH-Associated Protein 1/genetics ; Male ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/pathology ; NF-E2-Related Factor 2/genetics ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Osteoblasts/pathology ; Osteonecrosis/chemically induced ; Osteonecrosis/metabolism ; Osteonecrosis/pathology ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł:
Croton tiglium essential oil compounds have anti-proliferative and pro-apoptotic effects in A549 lung cancer cell lines.
Autorzy:
Niu QL; Shandong Provincial Key Laboratory of Fruit Tree Biotechnology Breeding, Shandong Institute of Pomology, Tai'an, Shandong, China.
Sun H; Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs/Key Laboratory of Agro-Products Processing Technology of Shandong Province/Institute of Agro-Food Science and Technology, Shandong Academy of Agricultural Sciences, Jinan, Shandong, China.
Liu C; Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs/Key Laboratory of Agro-Products Processing Technology of Shandong Province/Institute of Agro-Food Science and Technology, Shandong Academy of Agricultural Sciences, Jinan, Shandong, China.
Li J; Taian Traditional Chinese Medicine Hospital, Tai'an, Shandong, China.
Liang CX; School of Water Conservancy and Environment, University of Jinan, Jinan, Shandong, China.
Zhang RR; Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs/Key Laboratory of Agro-Products Processing Technology of Shandong Province/Institute of Agro-Food Science and Technology, Shandong Academy of Agricultural Sciences, Jinan, Shandong, China.
Ge FR; Shandong Provincial Key Laboratory of Fruit Tree Biotechnology Breeding, Shandong Institute of Pomology, Tai'an, Shandong, China.
Liu W; Shandong Provincial Key Laboratory of Fruit Tree Biotechnology Breeding, Shandong Institute of Pomology, Tai'an, Shandong, China.
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Źródło:
PloS one [PLoS One] 2020 May 01; Vol. 15 (5), pp. e0231437. Date of Electronic Publication: 2020 May 01 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Cell Proliferation*
Antineoplastic Agents, Phytogenic/*pharmacology
Croton/*chemistry
Lung Neoplasms/*drug therapy
Oils, Volatile/*pharmacology
A549 Cells ; Antineoplastic Agents, Phytogenic/isolation & purification ; Cell Cycle ; Cell Movement ; Chromatography, Supercritical Fluid ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Membrane Potential, Mitochondrial ; Oils, Volatile/isolation & purification ; Signal Transduction
Czasopismo naukowe
Tytuł:
Influence of Chronic Ethanol Consumption on Apoptosis and Autophagy Following Transient Focal Cerebral Ischemia in Male Mice.
Autorzy:
Li C; Department of Cellular Biology & Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, USA.
Li J; Department of Cellular Biology & Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, USA.
Xu G; Department of Cellular Biology & Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, USA.
Sun H; Department of Cellular Biology & Anatomy, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Apr 09; Vol. 10 (1), pp. 6164. Date of Electronic Publication: 2020 Apr 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Alcohol Drinking/*adverse effects
Apoptosis/*drug effects
Autophagy/*drug effects
Ischemic Attack, Transient/*pathology
Animals ; Blotting, Western ; DNA Fragmentation/drug effects ; Disease Models, Animal ; Ethanol/adverse effects ; In Situ Nick-End Labeling ; Ischemic Attack, Transient/complications ; Male ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł:
Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing.
Autorzy:
Li J; School of Life Sciences, University of Science and Technology of China, Hefei, China.; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
Wang C; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
Feng G; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
Zhang L; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Chen G; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
Sun H; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Wang J; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; College of Life Science, Northeast Agricultural University of China, Harbin, China.
Zhang Y; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
Zhou Q; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Li W; School of Life Sciences, University of Science and Technology of China, Hefei, China.; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
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Źródło:
Cell proliferation [Cell Prolif] 2020 Jan; Vol. 53 (1), pp. e12724. Date of Electronic Publication: 2019 Dec 03.
Typ publikacji:
Journal Article
MeSH Terms:
Alternative Splicing*
Apoptosis*
Embryonic Development*
Genomic Instability*
Mouse Embryonic Stem Cells/*metabolism
Transcription Factors/*metabolism
Animals ; DNA Damage ; Female ; Male ; Mice ; Mice, Inbred ICR ; Mice, Knockout ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł:
Sika deer antler protein against acetaminophen-induced oxidative stress and apoptosis in HK-2 cells via activating Nrf2/keap1/HO-1 pathway.
Autorzy:
Ruan H; College of Chinese Medicine Materials, Jilin Agricultural University, Chang Chun, China.
Wang L; College of Medicine, Changchun Sci-Tech University, Chang Chun, China.
Wang J; Department of Neurology, Jilin Province FAW General Hospital, Chang Chun, China.
Sun H; College of Chinese Medicine Materials, Jilin Agricultural University, Chang Chun, China.
He X; College of Chinese Medicine Materials, Jilin Agricultural University, Chang Chun, China.
Li W; College of Chinese Medicine Materials, Jilin Agricultural University, Chang Chun, China.
Zhang J; College of Chinese Medicine Materials, Jilin Agricultural University, Chang Chun, China.; College of Medicine, Changchun Sci-Tech University, Chang Chun, China.
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Źródło:
Journal of food biochemistry [J Food Biochem] 2019 Dec; Vol. 43 (12), pp. e13067. Date of Electronic Publication: 2019 Oct 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetaminophen/*adverse effects
Apoptosis/*drug effects
Kelch-Like ECH-Associated Protein 1/*metabolism
Lipocalin-2/*metabolism
NF-E2-Related Factor 2/*metabolism
Oxidative Stress/*drug effects
Signal Transduction/*drug effects
Animals ; Antlers ; Deer
Czasopismo naukowe
Tytuł:
Inhibition of microRNA‑124‑3p protects against acute myocardial infarction by suppressing the apoptosis of cardiomyocytes.
Autorzy:
Hu G; Emergency Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Ma L; Emergency Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Dong F; Emergency Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Hu X; Emergency Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Liu S; Emergency Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Sun H; Emergency Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2019 Oct; Vol. 20 (4), pp. 3379-3387. Date of Electronic Publication: 2019 Aug 06.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
MicroRNAs/*metabolism
Myocardial Infarction/*metabolism
Myocytes, Cardiac/*metabolism
Adult ; Animals ; Apoptosis Regulatory Proteins/metabolism ; Cell Line ; Cytokines/metabolism ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/pathology ; Myocardial Infarction/prevention & control ; Myocytes, Cardiac/pathology ; Rats
Czasopismo naukowe
Tytuł:
Bax Targeted by miR-29a Regulates Chondrocyte Apoptosis in Osteoarthritis.
Autorzy:
Miao G; Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.; Department of Orthopedics, Nanhai Hospital of Southern Medical University and Foshan Nanhai District People's Hospital, Guangdong 528200, China.
Zang X; Department of Orthopedics, Nanhai Hospital of Southern Medical University and Foshan Nanhai District People's Hospital, Guangdong 528200, China.
Hou H; Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Sun H; Department of Orthopedics, Nanhai Hospital of Southern Medical University and Foshan Nanhai District People's Hospital, Guangdong 528200, China.
Wang L; Department of Orthopedics, Nanhai Hospital of Southern Medical University and Foshan Nanhai District People's Hospital, Guangdong 528200, China.
Zhang T; Department of Orthopedics, Nanhai Hospital of Southern Medical University and Foshan Nanhai District People's Hospital, Guangdong 528200, China.
Tan Y; Department of Orthopedics, Nanhai Hospital of Southern Medical University and Foshan Nanhai District People's Hospital, Guangdong 528200, China.
Liu W; Department of Orthopedics, Nanhai Hospital of Southern Medical University and Foshan Nanhai District People's Hospital, Guangdong 528200, China.
Ye P; Department of Orthopedics, Nanhai Hospital of Southern Medical University and Foshan Nanhai District People's Hospital, Guangdong 528200, China.
Gao L; Department of Orthopedics, Nanhai Hospital of Southern Medical University and Foshan Nanhai District People's Hospital, Guangdong 528200, China.
Zha Z; Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
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Źródło:
BioMed research international [Biomed Res Int] 2019 Mar 12; Vol. 2019, pp. 1434538. Date of Electronic Publication: 2019 Mar 12 (Print Publication: 2019).
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Gene Expression Regulation*
Chondrocytes/*metabolism
MicroRNAs/*biosynthesis
Osteoarthritis/*metabolism
bcl-2-Associated X Protein/*biosynthesis
Aged ; Aged, 80 and over ; Chondrocytes/pathology ; Humans ; Male ; MicroRNAs/genetics ; Middle Aged ; Osteoarthritis/genetics ; Osteoarthritis/pathology ; bcl-2-Associated X Protein/genetics
Czasopismo naukowe
Tytuł:
Effects of nuclear respiratory factor‑1 on apoptosis and mitochondrial dysfunction induced by cobalt chloride in H9C2 cells.
Autorzy:
Niu N; College of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750001, P.R. China.
Li Z; School of Pharmacy, Tsinghua University, Beijing 100084, P.R. China.
Zhu M; College of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750001, P.R. China.
Sun H; College of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750001, P.R. China.
Yang J; College of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750001, P.R. China.
Xu S; College of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750001, P.R. China.
Zhao W; College of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750001, P.R. China.
Song R; Department of Critical Care Medicine, The Fifth Hospital of the Chinese People's Liberation Army, Yinchuan, Ningxia Hui Autonomous Region 750001, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2019 Mar; Vol. 19 (3), pp. 2153-2163. Date of Electronic Publication: 2019 Jan 10.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Cobalt/*pharmacology
Mitochondria/*drug effects
Nuclear Respiratory Factor 1/*genetics
Animals ; Apoptosis/genetics ; Cell Hypoxia/drug effects ; Cell Hypoxia/genetics ; Cell Line ; Cell Survival/drug effects ; Energy Metabolism/drug effects ; Energy Metabolism/genetics ; Flow Cytometry ; Gene Expression Regulation/drug effects ; Humans ; Mitochondria/pathology ; Oxygen Consumption/drug effects ; Rats ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł:
DNA damage and apoptosis induced by a potent orally podophyllotoxin derivative in breast cancer.
Autorzy:
Wang Y; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Sun H; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China. .
Xiao Z; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Zhang G; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Zhang D; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Bao X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Li F; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Wu S; Guangdong Province Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, China.
Gao Y; Beijing Tsinghua Changgeng Hospital, Beijing, China.
Wei N; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. .; Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2018 Sep 03; Vol. 16 (1), pp. 52. Date of Electronic Publication: 2018 Sep 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Damage*
Apoptosis/*drug effects
Breast Neoplasms/*genetics
Breast Neoplasms/*pathology
Podophyllotoxin/*analogs & derivatives
Podophyllotoxin/*pharmacology
Administration, Oral ; Animals ; Breast Neoplasms/drug therapy ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; DNA Topoisomerases, Type II/chemistry ; DNA Topoisomerases, Type II/metabolism ; Female ; Humans ; MCF-7 Cells ; Mice ; Molecular Docking Simulation ; Phosphatidylinositol 3-Kinases/metabolism ; Podophyllotoxin/administration & dosage ; Podophyllotoxin/metabolism ; Poly-ADP-Ribose Binding Proteins/chemistry ; Poly-ADP-Ribose Binding Proteins/metabolism ; Protein Conformation ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-mdm2/metabolism ; Reactive Oxygen Species/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Hydrogen sulfide is expressed in the human and the rat cultured nucleus pulposus cells and suppresses apoptosis induced by hypoxia.
Autorzy:
Sun H; Department of Orthopedic, Peking University First Hospital, Beijing, China.
Qi L; Department of Orthopedic, Peking University First Hospital, Beijing, China.
Wang S; Department of Orthopedic, Peking University First Hospital, Beijing, China.
Li X; Department of Orthopedic, Peking University First Hospital, Beijing, China.
Li C; Department of Orthopedic, Peking University First Hospital, Beijing, China.
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Źródło:
PloS one [PLoS One] 2018 Feb 21; Vol. 13 (2), pp. e0192556. Date of Electronic Publication: 2018 Feb 21 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Cell Hypoxia*
Hydrogen Sulfide/*metabolism
Nucleus Pulposus/*metabolism
Animals ; Cells, Cultured ; Humans ; Intervertebral Disc Displacement/metabolism ; Intervertebral Disc Displacement/therapy ; Male ; Nucleus Pulposus/cytology ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł:
Csseverin inhibits apoptosis through mitochondria-mediated pathways triggered by Ca2 + dyshomeostasis in hepatocarcinoma PLC cells.
Autorzy:
Shi M; Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhou L; Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China.
Zhao L; Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China.
Shang M; Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China.
He T; School of Public Health, Sun Yat-Sen University, Guangzhou, China.
Tang Z; Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China.
Sun H; Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China.
Ren P; Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China.
Lin Z; Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China.
Chen T; Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China.
Yu J; Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China.
Xu J; Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China.
Yu X; Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China.
Huang Y; Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2017 Nov 10; Vol. 11 (11), pp. e0006074. Date of Electronic Publication: 2017 Nov 10 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Clonorchis sinensis/*pathogenicity
Helminth Proteins/*metabolism
Mitochondria/*drug effects
Animals ; Cell Line, Tumor ; Cell Survival/drug effects ; Humans
Czasopismo naukowe
Tytuł:
[Enhancement of thermal damage to EpCAM-positive tumor cells by novel aptamer-guided magnetic nanoparticles].
Autorzy:
Zhang LY; Shanxi Institute of Pediatric Diseases, Xi'an Children's Hospital, Xi'an 710002, China.
Wang M; Department of Orthopaedics, 11 Military Hospital of China, Yining 835000, China.
Wu HB; Science and Education Division, Xi'an Children's Hospital, Xi'an 710002, China.
Yang Y; Shanxi Institute of Pediatric Diseases, Xi'an Children's Hospital, Xi'an 710002, China.
Li Q; Clinical Laboratory, Xi'an Children's Hospital, Xi'an 710002, China.
Sun HL; Shanxi Institute of Pediatric Diseases, Xi'an Children's Hospital, Xi'an 710002, China.
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Źródło:
Zhonghua zhong liu za zhi [Chinese journal of oncology] [Zhonghua Zhong Liu Za Zhi] 2017 Oct 23; Vol. 39 (10), pp. 726-731.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Epithelial Cell Adhesion Molecule*/metabolism
Aptamers, Nucleotide/*chemistry
Hyperthermia, Induced/*methods
Magnetite Nanoparticles/*chemistry
Magnetite Nanoparticles/*therapeutic use
Neoplasms/*therapy
Aptamers, Nucleotide/metabolism ; Bacterial Proteins/chemistry ; Biotin/analogs & derivatives ; Biotin/chemistry ; Cell Line, Tumor ; Combinatorial Chemistry Techniques/methods ; Humans ; Staining and Labeling/methods
Czasopismo naukowe
Tytuł:
Nicotine Inhibits Cisplatin-Induced Apoptosis via Regulating α5-nAChR/AKT Signaling in Human Gastric Cancer Cells.
Autorzy:
Jia Y; Central Laboratory, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
Sun H; College of Life Science, Shandong Normal University, Jinan, China.
Wu H; Central Laboratory, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
Zhang H; Central Laboratory, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
Zhang X; Central Laboratory, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
Xiao D; Central Laboratory, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
Ma X; Central Laboratory, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
Wang Y; Central Laboratory, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
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Źródło:
PloS one [PLoS One] 2016 Feb 24; Vol. 11 (2), pp. e0149120. Date of Electronic Publication: 2016 Feb 24 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cisplatin*/antagonists & inhibitors
Cisplatin*/pharmacology
Nicotine*/antagonists & inhibitors
Nicotine*/pharmacology
Stomach Neoplasms*/drug therapy
Stomach Neoplasms*/metabolism
Stomach Neoplasms*/pathology
Apoptosis/*drug effects
Proto-Oncogene Proteins c-akt/*metabolism
Receptors, Nicotinic/*metabolism
Signal Transduction/*drug effects
Cell Line, Tumor ; Female ; Humans ; Male
Czasopismo naukowe
Tytuł:
Curcumin Protects Neonatal Rat Cardiomyocytes against High Glucose-Induced Apoptosis via PI3K/Akt Signalling Pathway.
Autorzy:
Yu W; Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic Disorders, Hubei University of Science and Technology, Xianning 437100, China; Department of Pharmacology, Hubei University of Science and Technology, Xianning 437100, China.
Zha W; Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic Disorders, Hubei University of Science and Technology, Xianning 437100, China.
Ke Z; Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic Disorders, Hubei University of Science and Technology, Xianning 437100, China.
Min Q; Department of Pharmacology, Hubei University of Science and Technology, Xianning 437100, China.
Li C; Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic Disorders, Hubei University of Science and Technology, Xianning 437100, China.
Sun H; Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Liu C; Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic Disorders, Hubei University of Science and Technology, Xianning 437100, China.
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Źródło:
Journal of diabetes research [J Diabetes Res] 2016; Vol. 2016, pp. 4158591. Date of Electronic Publication: 2016 Feb 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antioxidants/*pharmacology
Apoptosis/*drug effects
Curcumin/*pharmacology
Glucose/*toxicity
Myocytes, Cardiac/*drug effects
Phosphatidylinositol 3-Kinase/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Signal Transduction/*drug effects
Animals ; Animals, Newborn ; Cardiotoxicity ; Cells, Cultured ; Cytoprotection ; Dose-Response Relationship, Drug ; Lipid Peroxidation/drug effects ; Myocytes, Cardiac/enzymology ; Myocytes, Cardiac/pathology ; NADPH Oxidases/metabolism ; Oxidative Stress/drug effects ; Rats, Sprague-Dawley ; Superoxides/metabolism
Czasopismo naukowe
Tytuł:
Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen‑activated protein kinase kinase signaling pathways.
Autorzy:
Hu S
Huang L
Meng L
Sun H
Zhang W
Xu Y
Pokaż więcej
Źródło:
Molecular medicine reports [Mol Med Rep] 2015 Nov; Vol. 12 (5), pp. 6745-51.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Breast Neoplasms/*drug therapy
Cell Proliferation/*drug effects
Quercetin/*analogs & derivatives
Breast Neoplasms/enzymology ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Screening Assays, Antitumor ; Epidermal Growth Factor/physiology ; Female ; Humans ; MAP Kinase Signaling System ; NF-kappa B/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Quercetin/pharmacology
Czasopismo naukowe
Tytuł:
Overexpression of Klotho suppresses liver cancer progression and induces cell apoptosis by negatively regulating wnt/β-catenin signaling pathway.
Autorzy:
Sun H; Department of Hepatobiliary, Surgery Liaocheng People's Hospital, Liaocheng, 252000, Shandong Province, China.; Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, Shandong Province, China.
Gao Y; Department of Hepatobiliary, Surgery Liaocheng People's Hospital, Liaocheng, 252000, Shandong Province, China.
Lu K; Department of Gastroenterology, Liaocheng People's Hospital, Liaocheng, 252000, Shandong Province, China.
Zhao G; Department of Hepatobiliary, Surgery Liaocheng People's Hospital, Liaocheng, 252000, Shandong Province, China.
Li X; Department of Hepatobiliary, Surgery Liaocheng People's Hospital, Liaocheng, 252000, Shandong Province, China.
Li Z; Department of Hepatobiliary, Surgery Liaocheng People's Hospital, Liaocheng, 252000, Shandong Province, China.
Chang H; Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, Shandong Province, China. changhong_.
Pokaż więcej
Źródło:
World journal of surgical oncology [World J Surg Oncol] 2015 Oct 24; Vol. 13, pp. 307. Date of Electronic Publication: 2015 Oct 24.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Carcinoma, Hepatocellular/*pathology
Glucuronidase/*metabolism
Liver Neoplasms/*pathology
Wnt Proteins/*metabolism
beta Catenin/*metabolism
Animals ; Blotting, Western ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Cell Proliferation ; Colony-Forming Units Assay ; Flow Cytometry ; Glucuronidase/genetics ; Humans ; Klotho Proteins ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Mice ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Tumor Cells, Cultured ; Wnt Proteins/genetics ; beta Catenin/genetics
Czasopismo naukowe

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