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Tytuł :
Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y 2 and GPR17.
Autorzy :
Pillaiyar T; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany.
Funke M; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany.
Al-Hroub H; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany.
Weyler S; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany.
Ivanova S; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany.
Schlegel J; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany.
Abdelrahman A; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany.
Müller CE; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 Jan 15; Vol. 186, pp. 111789. Date of Electronic Publication: 2019 Oct 18.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Receptors, G-Protein-Coupled/*antagonists & inhibitors
Receptors, Purinergic P2Y2/*metabolism
Suramin/*pharmacology
Animals ; CHO Cells ; Cricetulus ; Dose-Response Relationship, Drug ; Humans ; Microsomes, Liver/chemistry ; Microsomes, Liver/metabolism ; Molecular Structure ; Receptors, G-Protein-Coupled/metabolism ; Structure-Activity Relationship ; Suramin/chemical synthesis ; Suramin/chemistry
Czasopismo naukowe
Tytuł :
Thermodynamic profiles of the interactions of suramin, chondroitin sulfate, and pentosan polysulfate with the inhibitory domain of TIMP-3.
Autorzy :
Logue T; Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, 33431, USA.
Lizotte-Waniewski M; Integrated Medical Sciences Department, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, 33431, USA.
Brew K; Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, 33431, USA.
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Źródło :
FEBS letters [FEBS Lett] 2020 Jan; Vol. 594 (1), pp. 94-103. Date of Electronic Publication: 2019 Sep 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Molecular Docking Simulation*
Chondroitin Sulfates/*pharmacology
Pentosan Sulfuric Polyester/*pharmacology
Suramin/*pharmacology
Tissue Inhibitor of Metalloproteinase-3/*chemistry
Binding Sites ; Chondroitin Sulfates/chemistry ; Humans ; Pentosan Sulfuric Polyester/chemistry ; Protein Binding ; Suramin/chemistry ; Tissue Inhibitor of Metalloproteinase-3/metabolism
Czasopismo naukowe
Tytuł :
The antagonist of P2Y11 receptor NF157 ameliorates oxidized LDL-induced vascular endothelial inflammation.
Autorzy :
Kuang Y; a Department of Health Care , Shenzhen Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine , Shenzhen , China.
Liu H; b Institute of Metabolic Diseases , the 5th Affiliated Hospital of Shenzhen University Health Science Center , Shenzhen , China.
Guo S; b Institute of Metabolic Diseases , the 5th Affiliated Hospital of Shenzhen University Health Science Center , Shenzhen , China.
Wang Y; b Institute of Metabolic Diseases , the 5th Affiliated Hospital of Shenzhen University Health Science Center , Shenzhen , China.
Zhang H; b Institute of Metabolic Diseases , the 5th Affiliated Hospital of Shenzhen University Health Science Center , Shenzhen , China.
Qiao Y; b Institute of Metabolic Diseases , the 5th Affiliated Hospital of Shenzhen University Health Science Center , Shenzhen , China.; c Department of Internal Medicine , Baoan Central Hospital of Shenzhen , Shenzhen , China.; d Department of Emergency and Critical Care Medicine , the 5th Affiliated Hospital of Shenzhen University Health Science Center , Shenzhen , China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2019 Dec; Vol. 47 (1), pp. 1839-1845.
Typ publikacji :
Journal Article
MeSH Terms :
Human Umbilical Vein Endothelial Cells/*drug effects
Lipoproteins, LDL/*pharmacology
Receptors, Purinergic P2/*metabolism
Suramin/*analogs & derivatives
Cell Adhesion/drug effects ; E-Selectin/genetics ; Enzyme Activation/drug effects ; Gene Expression Regulation/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells/pathology ; Humans ; Inflammation/drug therapy ; Interleukin-6/biosynthesis ; Monocytes/cytology ; Monocytes/drug effects ; NF-kappa B/metabolism ; Oxidative Stress/drug effects ; Signal Transduction/drug effects ; Suramin/pharmacology ; Suramin/therapeutic use ; Tumor Necrosis Factor-alpha/biosynthesis ; Vascular Cell Adhesion Molecule-1/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model.
Autorzy :
Ndung'u K; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Murilla GA; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.; KAG EAST University, Nairobi, Kenya.
Thuita JK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.; Meru University of Science and Technology, Meru, Kenya.
Ngae GN; Food Crops Research Institute, Kenya Agricultural and Livestock Research Organization, Nairobi, Kenya.
Auma JE; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Gitonga PK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Thungu DK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Kurgat RK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Chemuliti JK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Mdachi RE; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
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Źródło :
PloS one [PLoS One] 2020 Nov 05; Vol. 15 (11), pp. e0229060. Date of Electronic Publication: 2020 Nov 05 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Trypanocidal Agents/*pharmacology
Trypanosoma brucei rhodesiense/*drug effects
Trypanosomiasis, African/*drug therapy
Virulence/*drug effects
Animals ; Diminazene/analogs & derivatives ; Diminazene/pharmacology ; Disease Models, Animal ; Drug Resistance/drug effects ; Kenya ; Male ; Melarsoprol/pharmacology ; Mice ; Pentamidine/pharmacology ; Suramin/pharmacology ; Treatment Outcome ; Trypanosomiasis, African/parasitology ; Uganda
Czasopismo naukowe
Tytuł :
The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10.
Autorzy :
Paulson CN; Department of Medicinal Chemistry and Institute for Therapeutics Discovery & Development, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, USA.
John K; Department of Medicinal Chemistry and Institute for Therapeutics Discovery & Development, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, USA.
Baxley RM; Department of Biochemistry, Molecular Biology and Biophysics, College of Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA.
Kurniawan F; Department of Biochemistry, Molecular Biology and Biophysics, College of Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA.
Orellana K; Department of Biochemistry, Molecular Biology and Biophysics, College of Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA.
Francis R; Department of Medicinal Chemistry and Institute for Therapeutics Discovery & Development, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, USA.
Sobeck A; Department of Biochemistry, Molecular Biology and Biophysics, College of Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA.
Eichman BF; Departments of Biological Sciences and Biochemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA.
Chazin WJ; Departments of Biochemistry and Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, USA.
Aihara H; Department of Biochemistry, Molecular Biology and Biophysics, College of Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA.
Georg GI; Department of Medicinal Chemistry and Institute for Therapeutics Discovery & Development, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, USA.
Hawkinson JE; Department of Medicinal Chemistry and Institute for Therapeutics Discovery & Development, College of Pharmacy, University of Minnesota, Minneapolis, MN 55414, USA.
Bielinsky AK; Department of Biochemistry, Molecular Biology and Biophysics, College of Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA.
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Źródło :
Open biology [Open Biol] 2019 Aug 30; Vol. 9 (8), pp. 190117. Date of Electronic Publication: 2019 Aug 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Enzyme Inhibitors/*pharmacology
Minichromosome Maintenance Proteins/*antagonists & inhibitors
Suramin/*pharmacology
Animals ; Cell Survival/drug effects ; Cell Survival/genetics ; DNA Replication/drug effects ; DNA-Binding Proteins/antagonists & inhibitors ; Drug Discovery/methods ; Enzyme Inhibitors/chemistry ; Gene Expression ; High-Throughput Nucleotide Sequencing ; Humans ; Kinetics ; Minichromosome Maintenance Proteins/genetics ; Molecular Structure ; Protein Binding ; Suramin/analogs & derivatives ; Suramin/chemistry ; Xenopus
Czasopismo naukowe
Tytuł :
The anti-parasitic drug suramin potently inhibits formation of seminal amyloid fibrils and their interaction with HIV-1.
Autorzy :
Tan S; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Li JQ; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Cheng H; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Li Z; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Lan Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Zhang TT; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Yang ZC; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Li W; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Qi T; Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Qiu YR; Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Chen Z; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Li L; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Liu SW; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Sep 13; Vol. 294 (37), pp. 13740-13754. Date of Electronic Publication: 2019 Jul 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid/*drug effects
Semen/*drug effects
Suramin/*pharmacology
Adult ; Animals ; Anti-HIV Agents/pharmacology ; Anti-Retroviral Agents/pharmacology ; HIV Infections/metabolism ; HIV-1/metabolism ; Healthy Volunteers ; Humans ; Male ; Peptide Fragments/metabolism ; Peptides/metabolism ; Rabbits ; Semen/metabolism ; Suramin/metabolism
Czasopismo naukowe
Tytuł :
Manipulating Active Structure and Function of Cationic Antimicrobial Peptide CM15 with the Polysulfonated Drug Suramin: A Step Closer to in Vivo Complexity.
Autorzy :
Quemé-Peña M; Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, 1117, Budapest, Hungary.
Juhász T; Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, 1117, Budapest, Hungary.
Mihály J; Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, 1117, Budapest, Hungary.
Cs Szigyártó I; Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, 1117, Budapest, Hungary.
Horváti K; MTA-ELTE Research Group of Peptide Chemistry, Hungarian Academy of Sciences, Eötvös Loránd University, Pázmány Péter sétány 1/A, 1117, Budapest, Hungary.
Bősze S; MTA-ELTE Research Group of Peptide Chemistry, Hungarian Academy of Sciences, Eötvös Loránd University, Pázmány Péter sétány 1/A, 1117, Budapest, Hungary.
Henczkó J; National Biosafety Laboratory, National Public Health Center, Albert Flórián út 2, 1097, Budapest, Hungary.
Pályi B; National Biosafety Laboratory, National Public Health Center, Albert Flórián út 2, 1097, Budapest, Hungary.
Németh C; Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, 1117, Budapest, Hungary.
Varga Z; Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, 1117, Budapest, Hungary.
Zsila F; Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, 1117, Budapest, Hungary.
Beke-Somfai T; Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, 1117, Budapest, Hungary.
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Źródło :
Chembiochem : a European journal of chemical biology [Chembiochem] 2019 Jun 14; Vol. 20 (12), pp. 1578-1590. Date of Electronic Publication: 2019 May 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Infective Agents*/chemistry
Anti-Infective Agents*/pharmacology
Antimicrobial Cationic Peptides*/chemistry
Antimicrobial Cationic Peptides*/pharmacology
Suramin*/chemistry
Suramin*/pharmacology
Cells, Cultured ; Circular Dichroism/methods ; Escherichia coli ; Humans ; Lipid Bilayers/chemistry ; Protein Structure, Secondary
Czasopismo naukowe
Tytuł :
In vivo experiments demonstrate the potent antileishmanial efficacy of repurposed suramin in visceral leishmaniasis.
Autorzy :
Khanra S; Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Bidhannagar, Kolkata India.
Juin SK; Division of Molecular Medicine, Bose Institute, Kolkata, India.
Jawed JJ; School of Biotechnology, Department of Life Sciences, Presidency University-New Campus, Kolkata, India.
Ghosh S; Division of Molecular Medicine, Bose Institute, Kolkata, India.
Dutta S; Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Bidhannagar, Kolkata, India.
Nabi SA; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Kolkata, India.
Dash J; Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India.
Dasgupta D; Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Bidhannagar, Kolkata, India.
Majumdar S; Division of Molecular Medicine, Bose Institute, Kolkata, India.
Banerjee R; Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Bidhannagar, Kolkata India.; Homi Bhabha National Institute, Anushakti Nagar, Mumbai, India.
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Źródło :
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Aug 31; Vol. 14 (8), pp. e0008575. Date of Electronic Publication: 2020 Aug 31 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiprotozoal Agents/*pharmacology
Antiprotozoal Agents/*therapeutic use
Leishmaniasis, Visceral/*drug therapy
Suramin/*pharmacology
Suramin/*therapeutic use
Animals ; Apoptosis/drug effects ; Cytokines/metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Inhibitory Concentration 50 ; Leishmania donovani/drug effects ; Leishmaniasis, Visceral/parasitology ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Mice, Inbred BALB C ; Nitric Oxide/metabolism ; Phosphoglycerate Kinase/drug effects ; RAW 264.7 Cells/drug effects ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules.
Autorzy :
Stevens M; Indiana University School of Medicine, Department of Biochemistry and Molecular Biology, 635 Barnhill Dr., Indianapolis, IN 46202, United States.
Abdeen S; Indiana University School of Medicine, Department of Biochemistry and Molecular Biology, 635 Barnhill Dr., Indianapolis, IN 46202, United States.
Salim N; Indiana University School of Medicine, Department of Biochemistry and Molecular Biology, 635 Barnhill Dr., Indianapolis, IN 46202, United States.
Ray AM; Indiana University School of Medicine, Department of Biochemistry and Molecular Biology, 635 Barnhill Dr., Indianapolis, IN 46202, United States.
Washburn A; Indiana University School of Medicine, Department of Biochemistry and Molecular Biology, 635 Barnhill Dr., Indianapolis, IN 46202, United States.
Chitre S; Indiana University School of Medicine, Department of Biochemistry and Molecular Biology, 635 Barnhill Dr., Indianapolis, IN 46202, United States.
Sivinski J; The University of Arizona, College of Pharmacy, Department of Pharmacology and Toxicology, 1703 E. Mabel St., PO Box 210207, Tucson, AZ 85721, United States.
Park Y; Indiana University School of Medicine, Department of Biochemistry and Molecular Biology, 635 Barnhill Dr., Indianapolis, IN 46202, United States; Stark Neurosciences Research Institute, Indiana University School of Medicine. 320 W. 15th Street, Suite 414, Indianapolis, IN 46202, United States; Department of Neurology, Indiana University School of Medicine. 635 Barnhill Drive, Indianapolis, IN 46202, United States.
Hoang QQ; Indiana University School of Medicine, Department of Biochemistry and Molecular Biology, 635 Barnhill Dr., Indianapolis, IN 46202, United States; Stark Neurosciences Research Institute, Indiana University School of Medicine. 320 W. 15th Street, Suite 414, Indianapolis, IN 46202, United States; Department of Neurology, Indiana University School of Medicine. 635 Barnhill Drive, Indianapolis, IN 46202, United States.
Chapman E; The University of Arizona, College of Pharmacy, Department of Pharmacology and Toxicology, 1703 E. Mabel St., PO Box 210207, Tucson, AZ 85721, United States.
Johnson SM; Indiana University School of Medicine, Department of Biochemistry and Molecular Biology, 635 Barnhill Dr., Indianapolis, IN 46202, United States. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 May 01; Vol. 29 (9), pp. 1106-1112. Date of Electronic Publication: 2019 Feb 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Products/*chemistry
Chaperonin 10/*metabolism
Chaperonin 60/*metabolism
Rafoxanide/*chemistry
Salicylanilides/*chemistry
Suramin/*chemistry
Biological Products/metabolism ; Chaperonin 10/antagonists & inhibitors ; Chaperonin 60/antagonists & inhibitors ; Escherichia coli/metabolism ; Humans ; Inhibitory Concentration 50 ; Protein Folding ; Rafoxanide/metabolism ; Salicylanilides/metabolism ; Suramin/metabolism
Czasopismo naukowe
Tytuł :
Repurposing suramin for the treatment of breast cancer lung metastasis with glycol chitosan-based nanoparticles.
Autorzy :
Cheng B; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, 715 Sumter St., Columbia, SC 29208, United States.
Gao F; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, 715 Sumter St., Columbia, SC 29208, United States.
Maissy E; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, 715 Sumter St., Columbia, SC 29208, United States.
Xu P; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, 715 Sumter St., Columbia, SC 29208, United States. Electronic address: .
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Źródło :
Acta biomaterialia [Acta Biomater] 2019 Jan 15; Vol. 84, pp. 378-390. Date of Electronic Publication: 2018 Dec 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Chitosan*/chemistry
Chitosan*/pharmacokinetics
Chitosan*/pharmacology
Doxorubicin*/chemistry
Doxorubicin*/pharmacokinetics
Doxorubicin*/pharmacology
Lung Neoplasms*/drug therapy
Lung Neoplasms*/metabolism
Lung Neoplasms*/pathology
Lung Neoplasms*/secondary
Nanoparticles*/chemistry
Nanoparticles*/therapeutic use
Suramin*/chemistry
Suramin*/pharmacokinetics
Suramin*/pharmacology
Triple Negative Breast Neoplasms*/drug therapy
Triple Negative Breast Neoplasms*/metabolism
Triple Negative Breast Neoplasms*/pathology
Animals ; Cell Line, Tumor ; Female ; Human Umbilical Vein Endothelial Cells ; Humans ; Hydrophobic and Hydrophilic Interactions ; Mice ; Mice, Nude ; Neoplasm Metastasis ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Suramin and NF449 are IP5K inhibitors that disrupt inositol hexakisphosphate-mediated regulation of cullin-RING ligase and sensitize cancer cells to MLN4924/pevonedistat.
Autorzy :
Zhang X; College of Biological Sciences, China Agricultural University, Beijing, China.; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Shi S; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Su Y; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Yang X; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
He S; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Yang X; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Wu J; Key Laboratory of Cell Differentiation and Apoptosis, Ministry of Education, Department of Pathophysiology, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Zhang J; Key Laboratory of Cell Differentiation and Apoptosis, Ministry of Education, Department of Pathophysiology, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Rao F; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Jul 24; Vol. 295 (30), pp. 10281-10292. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neoplasm Proteins*/antagonists & inhibitors
Neoplasm Proteins*/metabolism
Neoplasms*/drug therapy
Neoplasms*/enzymology
Neoplasms*/pathology
Phosphotransferases (Alcohol Group Acceptor)*/antagonists & inhibitors
Phosphotransferases (Alcohol Group Acceptor)*/metabolism
Benzenesulfonates/*pharmacology
Cullin Proteins/*metabolism
Cyclopentanes/*pharmacology
Enzyme Inhibitors/*pharmacology
Phytic Acid/*metabolism
Pyrimidines/*pharmacology
Suramin/*pharmacology
HCT116 Cells ; HEK293 Cells ; Humans
Czasopismo naukowe
Tytuł :
Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication Cycle.
Autorzy :
Salgado-Benvindo C; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
Thaler M; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
Tas A; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
Ogando NS; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
Bredenbeek PJ; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
Ninaber DK; Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
Wang Y; Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
Hiemstra PS; Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
Snijder EJ; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
van Hemert MJ; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands .
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Jul 22; Vol. 64 (8). Date of Electronic Publication: 2020 Jul 22 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Betacoronavirus/*drug effects
Coronavirus Infections/*drug therapy
Pneumonia, Viral/*drug therapy
Suramin/*pharmacology
Virus Replication/*drug effects
Animals ; COVID-19 ; Cell Line ; Chlorocebus aethiops ; Drug Evaluation, Preclinical ; Drug Repositioning ; Humans ; Pandemics ; SARS-CoV-2 ; Vero Cells ; Viral Load/drug effects
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes.
Autorzy :
Zoltner M; School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
Campagnaro GD; Institute for Infection, Immunity, and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Taleva G; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Institute of Parasitology, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
Burrell A; Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, United Kingdom.
Cerone M; Institute for Infection, Immunity, and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Leung KF; Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
Achcar F; Wellcome Centre for Integrative Parasitology and Glasgow Polyomics, University of Glasgow, Glasgow, United Kingdom.
Horn D; School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
Vaughan S; Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, United Kingdom.
Gadelha C; School of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
Zíková A; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Institute of Parasitology, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
Barrett MP; Wellcome Centre for Integrative Parasitology and Glasgow Polyomics, University of Glasgow, Glasgow, United Kingdom.
de Koning HP; Institute for Infection, Immunity, and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Field MC; School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom .; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Institute of Parasitology, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Jun 12; Vol. 295 (24), pp. 8331-8347. Date of Electronic Publication: 2020 Apr 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Energy Metabolism/*drug effects
Mitochondria/*metabolism
Suramin/*pharmacology
Trypanosoma brucei brucei/*metabolism
Adenosine Triphosphate/metabolism ; Flagella/drug effects ; Flagella/metabolism ; Flagella/ultrastructure ; Glycolysis/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Metabolome/drug effects ; Microbodies/drug effects ; Microbodies/metabolism ; Microbodies/ultrastructure ; Mitochondria/drug effects ; Mitochondria/ultrastructure ; Models, Molecular ; Proline/metabolism ; Proteome/metabolism ; Proton-Translocating ATPases/metabolism ; Protozoan Proteins/metabolism ; Pyruvic Acid/metabolism
Czasopismo naukowe
Tytuł :
Structure-based drug repositioning explains ibrutinib as VEGFR2 inhibitor.
Autorzy :
Adasme MF; Biotechnology Center (BIOTEC), Technische Universität Dresden, Dresden, Germany.
Parisi D; ESAT-STADIUS, KU Leuven, Heverlee, Belgium.
Van Belle K; Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium.
Salentin S; Biotechnology Center (BIOTEC), Technische Universität Dresden, Dresden, Germany.
Haupt VJ; Biotechnology Center (BIOTEC), Technische Universität Dresden, Dresden, Germany.; PharmAI GmbH, Dresden, Germany.
Jennings GS; Biotechnology Center (BIOTEC), Technische Universität Dresden, Dresden, Germany.
Heinrich JC; Biotechnology Center (BIOTEC), Technische Universität Dresden, Dresden, Germany.
Herman J; Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium.; Laboratory of Molecular Immunology (Rega institute), KU Leuven, Leuven, Belgium.; Department of Pediatric Nephrology and Solid Organ Transplantation, University Hospitals Leuven, Leuven, Belgium.
Sprangers B; Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium.; Laboratory of Molecular Immunology (Rega institute), KU Leuven, Leuven, Belgium.; Department of Nephrology, University Hospitals Leuven, Leuven, Belgium.
Louat T; Interface Valorisation Platform (IVAP), KU Leuven, Leuven, Belgium.
Moreau Y; ESAT-STADIUS, KU Leuven, Heverlee, Belgium.
Schroeder M; Biotechnology Center (BIOTEC), Technische Universität Dresden, Dresden, Germany.
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Źródło :
PloS one [PLoS One] 2020 May 27; Vol. 15 (5), pp. e0233089. Date of Electronic Publication: 2020 May 27 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Drug Repositioning/*methods
Pyrazoles/*chemistry
Pyrazoles/*pharmacology
Pyrimidines/*chemistry
Pyrimidines/*pharmacology
Vascular Endothelial Growth Factor Receptor-2/*antagonists & inhibitors
Agammaglobulinaemia Tyrosine Kinase/antagonists & inhibitors ; Agammaglobulinaemia Tyrosine Kinase/metabolism ; B-Lymphocytes/metabolism ; Humans ; Jurkat Cells ; RNA Interference ; Signal Transduction/drug effects ; Suramin/chemistry ; Suramin/pharmacology ; Vascular Endothelial Growth Factor Receptor-2/metabolism
Czasopismo naukowe
Tytuł :
Zika virus NS2B/NS3 proteinase: A new target for an old drug - Suramin a lead compound for NS2B/NS3 proteinase inhibition.
Autorzy :
Coronado MA; Multiuser Center for Biomolecular Innovation, Department of Physics, Universidade Estadual Paulista (UNESP), São José do Rio Preto SP, 15054-000, Brazil. Electronic address: .
Eberle RJ; Multiuser Center for Biomolecular Innovation, Department of Physics, Universidade Estadual Paulista (UNESP), São José do Rio Preto SP, 15054-000, Brazil.
Bleffert N; Institute of Complex System, Structural Biochemistry (ICS-6), Forchungszentrum Jülich, Germany; Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße, Germany.
Feuerstein S; Institute of Complex System, Structural Biochemistry (ICS-6), Forchungszentrum Jülich, Germany; Institute of Complex System, Structural Biochemistry (ICS-6), Forchungszentrum Jülich, Germany.
Olivier DS; Multiuser Center for Biomolecular Innovation, Department of Physics, Universidade Estadual Paulista (UNESP), São José do Rio Preto SP, 15054-000, Brazil.
de Moraes FR; Multiuser Center for Biomolecular Innovation, Department of Physics, Universidade Estadual Paulista (UNESP), São José do Rio Preto SP, 15054-000, Brazil.
Willbold D; Institute of Complex System, Structural Biochemistry (ICS-6), Forchungszentrum Jülich, Germany; Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße, Germany.
Arni RK; Multiuser Center for Biomolecular Innovation, Department of Physics, Universidade Estadual Paulista (UNESP), São José do Rio Preto SP, 15054-000, Brazil. Electronic address: .
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Źródło :
Antiviral research [Antiviral Res] 2018 Dec; Vol. 160, pp. 118-125. Date of Electronic Publication: 2018 Oct 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Protease Inhibitors/*pharmacology
Suramin/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Zika Virus/*drug effects
Zika Virus/*enzymology
Antiparasitic Agents/chemistry ; Antiparasitic Agents/pharmacology ; Antiviral Agents/chemistry ; Drug Repositioning ; Inhibitory Concentration 50 ; Magnetic Resonance Spectroscopy ; Molecular Dynamics Simulation ; Protease Inhibitors/chemistry ; Protein Binding ; RNA Helicases/antagonists & inhibitors ; RNA Helicases/chemistry ; RNA Helicases/metabolism ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/metabolism ; Suramin/chemistry ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Electrostatic Tuning of Anion Attraction from the Cytoplasm to the Pore of the CFTR Chloride Channel.
Autorzy :
Linsdell P; Department of Physiology and Biophysics, Dalhousie University, PO Box 15000, Halifax, NS, B3H 4R2, Canada. .
Negoda A; Department of Physiology and Biophysics, Dalhousie University, PO Box 15000, Halifax, NS, B3H 4R2, Canada.
Cowley EA; Department of Physiology and Biophysics, Dalhousie University, PO Box 15000, Halifax, NS, B3H 4R2, Canada.
El Hiani Y; Department of Physiology and Biophysics, Dalhousie University, PO Box 15000, Halifax, NS, B3H 4R2, Canada.
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Źródło :
Cell biochemistry and biophysics [Cell Biochem Biophys] 2020 Mar; Vol. 78 (1), pp. 15-22. Date of Electronic Publication: 2019 Dec 31.
Typ publikacji :
Journal Article
MeSH Terms :
Cystic Fibrosis Transmembrane Conductance Regulator/*metabolism
Cytoplasm/*metabolism
Animals ; Anions/chemistry ; Anions/metabolism ; Cell Line ; Coordination Complexes/chemistry ; Coordination Complexes/metabolism ; Cricetinae ; Cystic Fibrosis Transmembrane Conductance Regulator/antagonists & inhibitors ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Humans ; Mutagenesis, Site-Directed ; Patch-Clamp Techniques ; Platinum/chemistry ; Static Electricity ; Suramin/chemistry ; Suramin/metabolism
Czasopismo naukowe
Tytuł :
Spatial modeling of prostate cancer metabolic gene expression reveals extensive heterogeneity and selective vulnerabilities.
Autorzy :
Wang Y; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, 98109, USA. .; Paul G. Allen School of Computer Science & Engineering, University of Washington, Seattle, WA, 98195, USA. .
Ma S; Department of Microbiology, University of Washington, Seattle, WA, 98195, USA.
Ruzzo WL; Paul G. Allen School of Computer Science & Engineering, University of Washington, Seattle, WA, 98195, USA.; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, 98195, USA.; Fred Hutchinson Cancer Research Center, Seattle, WA, 98102, USA.
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Źródło :
Scientific reports [Sci Rep] 2020 Feb 26; Vol. 10 (1), pp. 3490. Date of Electronic Publication: 2020 Feb 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Metabolic Networks and Pathways/*genetics
Prostatic Neoplasms/*pathology
Arachidonic Acid/metabolism ; Cysteine/metabolism ; Databases, Factual ; Humans ; Male ; Organic Anion Transporters/antagonists & inhibitors ; Organic Anion Transporters/metabolism ; Prostatic Neoplasms/metabolism ; Stearoyl-CoA Desaturase/antagonists & inhibitors ; Stearoyl-CoA Desaturase/metabolism ; Succinic Acid/metabolism ; Suramin/chemistry ; Suramin/metabolism ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
100 Years of Suramin.
Autorzy :
Wiedemar N; Swiss Tropical and Public Health Institute, Department of Medical Parasitology and Infection Biology, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Hauser DA; Swiss Tropical and Public Health Institute, Department of Medical Parasitology and Infection Biology, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Mäser P; Swiss Tropical and Public Health Institute, Department of Medical Parasitology and Infection Biology, Basel, Switzerland .; University of Basel, Basel, Switzerland.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Feb 21; Vol. 64 (3). Date of Electronic Publication: 2020 Feb 21 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Suramin/*therapeutic use
Trypanocidal Agents/*therapeutic use
Trypanosomiasis, African/*drug therapy
Animals ; Humans ; Trypanosoma brucei rhodesiense/drug effects ; Trypanosoma brucei rhodesiense/pathogenicity ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism.
Autorzy :
Salvador GHM; Universidade Estadual Paulista (UNESP), Instituto de Biociências, Dep. de Física e Biofísica, Botucatu, SP, Brazil.
Dreyer TR; Universidade Estadual Paulista (UNESP), Instituto de Biociências, Dep. de Física e Biofísica, Botucatu, SP, Brazil.
Gomes AAS; Universidade Estadual Paulista (UNESP), Instituto de Biociências, Dep. de Física e Biofísica, Botucatu, SP, Brazil.
Cavalcante WLG; Universidade Estadual Paulista (UNESP), Instituto de Biociências, Dep. de Física e Biofísica, Botucatu, SP, Brazil.; Universidade Federal de Minas Gerais (UFMG), Instituto de Ciências Biológicas, Dep. de Farmacologia, Belo Horizonte, MG, Brazil.; Universidade Estadual Paulista (UNESP), Instituto de Biociências, Dep. de Farmacologia, Botucatu, SP, Brazil.
Dos Santos JI; Universidade Estadual Paulista (UNESP), Instituto de Biociências, Dep. de Física e Biofísica, Botucatu, SP, Brazil.
Gandin CA; Universidade Estadual Paulista (UNESP), Instituto de Biociências, Dep. de Física e Biofísica, Botucatu, SP, Brazil.
de Oliveira Neto M; Universidade Estadual Paulista (UNESP), Instituto de Biociências, Dep. de Física e Biofísica, Botucatu, SP, Brazil.
Gallacci M; Universidade Estadual Paulista (UNESP), Instituto de Biociências, Dep. de Farmacologia, Botucatu, SP, Brazil.
Fontes MRM; Universidade Estadual Paulista (UNESP), Instituto de Biociências, Dep. de Física e Biofísica, Botucatu, SP, Brazil. .
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Źródło :
Scientific reports [Sci Rep] 2018 Jul 09; Vol. 8 (1), pp. 10317. Date of Electronic Publication: 2018 Jul 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Phospholipases A2/*metabolism
Reptilian Proteins/*metabolism
Suramin/*chemistry
Animals ; Binding Sites ; Bothrops ; Crotalid Venoms/metabolism ; Crystallography, X-Ray ; Molecular Dynamics Simulation ; Phospholipases A2/chemistry ; Protein Structure, Quaternary ; Reptilian Proteins/chemistry ; Scattering, Small Angle ; Suramin/metabolism ; Thermodynamics
Czasopismo naukowe
Tytuł :
Self-assembled nanocomplex of PEGylated protamine and heparin-suramin conjugate for accumulation at the tumor site.
Autorzy :
Park J; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, Republic of Korea; Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, 136-791, Republic of Korea.
Hwang SR; College of Pharmacy, Chosun University, Gwangju, 501-759, Republic of Korea; Department of Biomedical Sciences, Graduate School, Chosun University, Gwangju, 501-759, Republic of Korea.
Choi JU; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, Republic of Korea.
Alam F; Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.
Byun Y; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Republic of Korea. Electronic address: .
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2018 Jan 15; Vol. 535 (1-2), pp. 38-46. Date of Electronic Publication: 2017 Oct 31.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Carriers/*chemistry
Heparin, Low-Molecular-Weight/*chemistry
Nanoconjugates/*chemistry
Neoplasms, Experimental/*metabolism
Protamines/*chemistry
Suramin/*chemistry
Animals ; Antineoplastic Agents/administration & dosage ; Cell Line, Tumor ; Drug Carriers/chemical synthesis ; Drug Carriers/pharmacokinetics ; Heparin, Low-Molecular-Weight/pharmacokinetics ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Docking Simulation ; Particle Size ; Polyethylene Glycols/chemistry ; Protamines/pharmacokinetics ; Suramin/pharmacokinetics ; Surface Properties ; Tissue Distribution
Czasopismo naukowe

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