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Wyszukujesz frazę ""Suramin"" wg kryterium: Temat

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Tytuł:
Suramin, an antiparasitic drug, stimulates adipocyte differentiation and promotes adipogenesis.
Autorzy:
Li H; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, 100191, Beijing, China.
Dong Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, 100191, Beijing, China.
Han C; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, 100191, Beijing, China.
Xia L; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, 100191, Beijing, China.
Zhang Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, 100191, Beijing, China.
Chen T; Key Laboratory of Functional and Clinical Translational Medicine, Department of Physiology, Xiamen Medical College, 361023, Xiamen, China.
Wang H; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, 100191, Beijing, China.
Xu G; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, 100191, Beijing, China. .; State Key Laboratory of Vascular Homeostasis and Remodeling，Peking University, Beijing, China. .
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Źródło:
Lipids in health and disease [Lipids Health Dis] 2023 Dec 13; Vol. 22 (1), pp. 222. Date of Electronic Publication: 2023 Dec 13.
Typ publikacji:
Journal Article
MeSH Terms:
Adipogenesis*
Suramin*/pharmacology
Rats ; Animals ; Antiparasitic Agents/pharmacology ; Cell Differentiation ; Adipocytes, White ; Heparin/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The importance of including the C-terminal domain of PTP1B 1-400 to identify potential antidiabetic inhibitors.
Autorzy:
Coronell-Tovar A; Departamento de Bioquímica, Facultad de Medicina, Laboratorio de Biosensores y Modelaje molecular, Universidad Nacional Autónoma de México, Ciudad de México, México.
Cortés-Benítez F; Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Xochimilco (UAM-X), Ciudad de México, México.
González-Andrade M; Departamento de Bioquímica, Facultad de Medicina, Laboratorio de Biosensores y Modelaje molecular, Universidad Nacional Autónoma de México, Ciudad de México, México.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2170369.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoglycemic Agents*/chemistry
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/chemistry
Kinetics ; Suramin ; Molecular Docking Simulation ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Ursolic Acid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Long-Term Effects of Suramin on Renal Function in Streptozotocin-Induced Diabetes in Rats.
Autorzy:
Chyła-Danił G; Department of Clinical Chemistry, Medical University of Gdańsk, Dębinki 7, 80-210 Gdańsk, Poland.
Sałaga-Zaleska K; Department of Clinical Chemistry, Medical University of Gdańsk, Dębinki 7, 80-210 Gdańsk, Poland.
Kreft E; Department of Clinical Chemistry, Medical University of Gdańsk, Dębinki 7, 80-210 Gdańsk, Poland.
Stumski O; Department of Clinical Chemistry, Medical University of Gdańsk, Dębinki 7, 80-210 Gdańsk, Poland.
Krzesińska A; Department of Clinical Chemistry, Medical University of Gdańsk, Dębinki 7, 80-210 Gdańsk, Poland.
Sakowicz-Burkiewicz M; Department of Molecular Medicine, Medical University of Gdańsk, Dębinki 7, 80-210 Gdańsk, Poland.
Kuchta A; Department of Clinical Chemistry, Medical University of Gdańsk, Dębinki 7, 80-210 Gdańsk, Poland.
Jankowski M; Department of Clinical Chemistry, Medical University of Gdańsk, Dębinki 7, 80-210 Gdańsk, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Sep 28; Vol. 24 (19). Date of Electronic Publication: 2023 Sep 28.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetic Nephropathies*/drug therapy
Diabetic Nephropathies*/metabolism
Diabetes Mellitus, Experimental*/drug therapy
Diabetes Mellitus, Experimental*/metabolism
Rats ; Animals ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; Suramin/pharmacology ; Streptozocin ; Acetylcholine/metabolism ; Nucleosomes/metabolism ; Kidney/metabolism ; Albumins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
1984-Discovery of the First Anti-HIV Drug, Suramin.
Autorzy:
De Clercq E; Rega Institute for Medical Research, Department of Microbiology, Immunology and Transplantation, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.
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Źródło:
Viruses [Viruses] 2021 Aug 19; Vol. 13 (8). Date of Electronic Publication: 2021 Aug 19.
Typ publikacji:
Editorial; Historical Article
MeSH Terms:
Acquired Immunodeficiency Syndrome/*drug therapy
Anti-HIV Agents/*history
Drug Discovery/*history
HIV/*drug effects
Suramin/*history
Acquired Immunodeficiency Syndrome/history ; Acquired Immunodeficiency Syndrome/virology ; Anti-HIV Agents/chemistry ; Anti-HIV Agents/therapeutic use ; HIV/genetics ; HIV/physiology ; History, 20th Century ; History, 21st Century ; Humans ; Suramin/chemistry ; Suramin/therapeutic use
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Repurposed Drugs Suramin and Quinacrine Cooperatively Inhibit SARS-CoV-2 3CL In Vitro.
Autorzy:
Eberle RJ; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, 52428 Jülich, Germany.; Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße, 40225 Düsseldorf, Germany.
Olivier DS; Campus Cimba, Federal University of Tocantins, Araguaína, TO 77824-838, Brazil.
Amaral MS; Institute of Physics, Federal University of Mato Grosso do Sul, Campo Grande, MS 79070-900, Brazil.
Gering I; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, 52428 Jülich, Germany.
Willbold D; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, 52428 Jülich, Germany.; Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße, 40225 Düsseldorf, Germany.; JuStruct: Jülich Centre for Structural Biology, Forchungszentrum Jülich, 52428 Jülich, Germany.
Arni RK; Multiuser Center for Biomolecular Innovation, IBILCE, Universidade Estadual Paulista (UNESP), São Jose do Rio Preto, SP 15054-000, Brazil.
Coronado MA; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, 52428 Jülich, Germany.; Multiuser Center for Biomolecular Innovation, IBILCE, Universidade Estadual Paulista (UNESP), São Jose do Rio Preto, SP 15054-000, Brazil.
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Źródło:
Viruses [Viruses] 2021 May 10; Vol. 13 (5). Date of Electronic Publication: 2021 May 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Coronavirus 3C Proteases/*drug effects
Quinacrine/*pharmacology
Suramin/*pharmacology
Antiviral Agents/pharmacology ; COVID-19 Vaccines/pharmacology ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/metabolism ; Cysteine Endopeptidases/metabolism ; Drug Repositioning ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Pandemics ; Protease Inhibitors/pharmacology ; Quinacrine/metabolism ; SARS-CoV-2/drug effects ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Suramin/metabolism ; Viral Nonstructural Proteins ; COVID-19 Drug Treatment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Suramin Targets the Conserved Ligand-Binding Pocket of Human Raf1 Kinase Inhibitory Protein.
Autorzy:
Guo C; Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Wu Z; Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Lin W; Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Xu H; Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Chang T; Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Dai Y; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Lin D; Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 21; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 21.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins c-raf/*antagonists & inhibitors
Suramin/*pharmacology
Binding Sites/drug effects ; HEK293 Cells ; Humans ; Ligands ; Molecular Docking Simulation ; Protein Kinase Inhibitors/chemistry ; Proto-Oncogene Proteins c-raf/isolation & purification ; Proto-Oncogene Proteins c-raf/metabolism ; Suramin/analogs & derivatives ; Suramin/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Suramin Disturbs the Association of the N-Terminal Domain of SARS-CoV-2 Nucleocapsid Protein with RNA.
Autorzy:
Guo C; Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Xu H; Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Li X; Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Yu J; Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Lin D; Key Laboratory of Chemical Biology of Fujian Province, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Mar 10; Vol. 28 (6). Date of Electronic Publication: 2023 Mar 10.
Typ publikacji:
Journal Article
MeSH Terms:
SARS-CoV-2*/metabolism
COVID-19*
Humans ; Suramin/pharmacology ; Nucleocapsid Proteins/chemistry ; Molecular Docking Simulation ; Models, Molecular ; RNA, Viral/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Suramin prevents the development of diabetic kidney disease by inhibiting NLRP3 inflammasome activation in KK-Ay mice.
Autorzy:
Oda K; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Miyamoto S; Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan.
Kodera R; Osafune Clinic, Setouchi, Japan.
Wada J; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Shikata K; Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan.
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Źródło:
Journal of diabetes investigation [J Diabetes Investig] 2023 Feb; Vol. 14 (2), pp. 205-220. Date of Electronic Publication: 2022 Oct 29.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetic Nephropathies*/metabolism
Diabetes Mellitus, Type 2*/complications
Diabetes Mellitus, Type 2*/metabolism
Mice ; Animals ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Interleukin-18 ; Suramin/pharmacology ; Mice, Inbred C57BL ; Adenosine Triphosphate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Molecular Targeting of VEGF with a Suramin Fragment-DOCA Conjugate by Mimicking the Action of Low Molecular Weight Heparins.
Autorzy:
Park J; Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Korea.
Kang TB; Department of Biotechnology, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Korea.
Lim JH; Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Korea.
Won HS; Department of Biotechnology, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Korea.
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Źródło:
Biomolecules [Biomolecules] 2020 Dec 31; Vol. 11 (1). Date of Electronic Publication: 2020 Dec 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Heparin/*chemistry
Suramin/*chemistry
Vascular Endothelial Growth Factor A/*genetics
Binding Sites/drug effects ; Desoxycorticosterone Acetate/chemistry ; Desoxycorticosterone Acetate/pharmacology ; Heparin/pharmacology ; Human Umbilical Vein Endothelial Cells ; Humans ; Suramin/pharmacology ; Surface Plasmon Resonance ; Vascular Endothelial Growth Factor A/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays.
Autorzy:
Su L; Biomolecular Sciences Institute, Florida International University, Miami, FL, 33199, USA.; Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA.
Bryan N; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL, 32827, USA.
Battista S; Istituto per l'Endocrinologia e l'Oncologia Sperimentale, CNR, Via Pansini 5, 80131, Naples, Italy.
Freitas J; Biomolecular Sciences Institute, Florida International University, Miami, FL, 33199, USA.; Department of Biological Sciences, Florida International University, Miami, FL, 33199, USA.
Garabedian A; Biomolecular Sciences Institute, Florida International University, Miami, FL, 33199, USA.; Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA.
D'Alessio F; Dipartimento Di Medicina Molecolare E Biotecnologie Mediche, Università Degli Studi 'Federico II' Di Napoli, Naples, Italy.
Romano M; Dipartimento Di Medicina Molecolare E Biotecnologie Mediche, Università Degli Studi 'Federico II' Di Napoli, Naples, Italy.
Falanga F; Dipartimento Di Medicina Molecolare E Biotecnologie Mediche, Università Degli Studi 'Federico II' Di Napoli, Naples, Italy.
Fusco A; Dipartimento Di Medicina Molecolare E Biotecnologie Mediche, Università Degli Studi 'Federico II' Di Napoli, Naples, Italy.
Kos L; Biomolecular Sciences Institute, Florida International University, Miami, FL, 33199, USA.; Department of Biological Sciences, Florida International University, Miami, FL, 33199, USA.
Chambers J; Biomolecular Sciences Institute, Florida International University, Miami, FL, 33199, USA.; Department of Environmental Health Sciences, Florida International University, Miami, FL, 33199, USA.
Fernandez-Lima F; Biomolecular Sciences Institute, Florida International University, Miami, FL, 33199, USA.; Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA.
Chapagain PP; Biomolecular Sciences Institute, Florida International University, Miami, FL, 33199, USA.; Department of Physics, Florida International University, Miami, FL, 33199, USA.
Vasile S; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL, 32827, USA.
Smith L; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL, 32827, USA.
Leng F; Biomolecular Sciences Institute, Florida International University, Miami, FL, 33199, USA. .; Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Nov 02; Vol. 10 (1), pp. 18850. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA-Binding Proteins/*antagonists & inhibitors
HMGA1a Protein/*antagonists & inhibitors
HMGA2 Protein/*antagonists & inhibitors
Suramin/*chemistry
Adipogenesis/drug effects ; Amino Acid Motifs/drug effects ; Base Sequence/drug effects ; Binding Sites/drug effects ; Carcinogenesis/drug effects ; DNA/drug effects ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; HMGA1a Protein/chemistry ; HMGA1a Protein/genetics ; HMGA2 Protein/chemistry ; HMGA2 Protein/genetics ; High-Throughput Screening Assays ; Humans ; Suramin/isolation & purification ; Suramin/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Suramin binds and inhibits infection of SARS-CoV-2 through both spike protein-heparan sulfate and ACE2 receptor interactions.
Autorzy:
Kwon PS; Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY, USA.; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
Xu S; Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.
Oh H; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea.; College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungcheongbuk, Republic of Korea.
Kwon SJ; Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.
Rodrigues AL; Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.
Feroz M; Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.
Fraser K; Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
He P; Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY, USA.
Zhang F; Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.
Hong JJ; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk, Republic of Korea. .
Linhardt RJ; Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY, USA. .; Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA. .; Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA. .
Dordick JS; Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA. .; Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA. .; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA. .
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Źródło:
Communications biology [Commun Biol] 2023 Apr 08; Vol. 6 (1), pp. 387. Date of Electronic Publication: 2023 Apr 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
SARS-CoV-2*
COVID-19*
Humans ; Suramin/pharmacology ; Angiotensin-Converting Enzyme 2 ; Spike Glycoprotein, Coronavirus ; Heparitin Sulfate
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Unusual Architecture of RNA-Dependent RNA Polymerase (RdRp)'s Catalytic Chamber Provides a Potential Strategy for Combination Therapy against COVID-19.
Autorzy:
Metwally K; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.; Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
Abo-Dya NE; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
Alahmdi MI; Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.
Albalawi MZ; Pharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.
Yahya G; Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
Aljoundi A; Molecular Bio-Computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4001, South Africa.
Salifu EY; Molecular Bio-Computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4001, South Africa.
Elamin G; Molecular Bio-Computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4001, South Africa.
Ibrahim MAA; Molecular Bio-Computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4001, South Africa.; CompChem Lab, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt.
Sayed Y; Protein Structure-Function Research Unit, School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg 2050, South Africa.
Fanucchi S; Protein Structure-Function Research Unit, School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg 2050, South Africa.
Soliman MES; Molecular Bio-Computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4001, South Africa.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Mar 20; Vol. 28 (6). Date of Electronic Publication: 2023 Mar 20.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*
Humans ; RNA-Dependent RNA Polymerase/metabolism ; SARS-CoV-2/metabolism ; RNA, Viral ; Suramin ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Antiviral Agents/chemistry ; Molecular Docking Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Initiation and modulation of Tau protein phase separation by the drug suramin.
Autorzy:
Prince PR; Institute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University of Hamburg, c/o DESY, 22603, Hamburg, Germany. .; The Hamburg Centre for Ultrafast Imaging (CUI), University of Hamburg, 2276, Hamburg, Germany. .
Hochmair J; German Center for Neurodegenerative Diseases (DZNE), 10117, Berlin, Germany.
Brognaro H; Institute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University of Hamburg, c/o DESY, 22603, Hamburg, Germany.
Gevorgyan S; Institute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University of Hamburg, c/o DESY, 22603, Hamburg, Germany.; The Hamburg Centre for Ultrafast Imaging (CUI), University of Hamburg, 2276, Hamburg, Germany.
Franck M; German Center for Neurodegenerative Diseases (DZNE), 10117, Berlin, Germany.
Schubert R; European XFEL GmbH, 22869, Schenefeld, Germany.
Lorenzen K; European XFEL GmbH, 22869, Schenefeld, Germany.
Yazici S; Institute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University of Hamburg, c/o DESY, 22603, Hamburg, Germany.
Mandelkow E; German Center for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany.; Department of Neurodegenerative Diseases and Gerontopsychiatry, Univ. Clinic, Bonn, 53127, Bonn, Germany.
Wegmann S; German Center for Neurodegenerative Diseases (DZNE), 10117, Berlin, Germany.
Betzel C; Institute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University of Hamburg, c/o DESY, 22603, Hamburg, Germany. .; The Hamburg Centre for Ultrafast Imaging (CUI), University of Hamburg, 2276, Hamburg, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 09; Vol. 13 (1), pp. 3963. Date of Electronic Publication: 2023 Mar 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
tau Proteins*/metabolism
Alzheimer Disease*/metabolism
Humans ; Suramin/pharmacology ; Heparin ; RNA/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The antagonist of P2Y11 receptor NF157 ameliorates oxidized LDL-induced vascular endothelial inflammation.
Autorzy:
Kuang Y; a Department of Health Care , Shenzhen Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine , Shenzhen , China.
Liu H; b Institute of Metabolic Diseases , the 5th Affiliated Hospital of Shenzhen University Health Science Center , Shenzhen , China.
Guo S; b Institute of Metabolic Diseases , the 5th Affiliated Hospital of Shenzhen University Health Science Center , Shenzhen , China.
Wang Y; b Institute of Metabolic Diseases , the 5th Affiliated Hospital of Shenzhen University Health Science Center , Shenzhen , China.
Zhang H; b Institute of Metabolic Diseases , the 5th Affiliated Hospital of Shenzhen University Health Science Center , Shenzhen , China.
Qiao Y; b Institute of Metabolic Diseases , the 5th Affiliated Hospital of Shenzhen University Health Science Center , Shenzhen , China.; c Department of Internal Medicine , Baoan Central Hospital of Shenzhen , Shenzhen , China.; d Department of Emergency and Critical Care Medicine , the 5th Affiliated Hospital of Shenzhen University Health Science Center , Shenzhen , China.
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Źródło:
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2019 Dec; Vol. 47 (1), pp. 1839-1845.
Typ publikacji:
Journal Article
MeSH Terms:
Human Umbilical Vein Endothelial Cells/*drug effects
Lipoproteins, LDL/*pharmacology
Receptors, Purinergic P2/*metabolism
Suramin/*analogs & derivatives
Cell Adhesion/drug effects ; E-Selectin/genetics ; Enzyme Activation/drug effects ; Gene Expression Regulation/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells/pathology ; Humans ; Inflammation/drug therapy ; Interleukin-6/biosynthesis ; Monocytes/cytology ; Monocytes/drug effects ; NF-kappa B/metabolism ; Oxidative Stress/drug effects ; Signal Transduction/drug effects ; Suramin/pharmacology ; Suramin/therapeutic use ; Tumor Necrosis Factor-alpha/biosynthesis ; Vascular Cell Adhesion Molecule-1/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effects of Suramin on Polycystic Kidney Disease in a Mouse Model of Polycystin-1 Deficiency.
Autorzy:
Chang MY; Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
Hsu SH; Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
Ma LY; Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
Chou LF; Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
Hung CC; Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
Tian YC; Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
Yang CW; Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jul 31; Vol. 23 (15). Date of Electronic Publication: 2022 Jul 31.
Typ publikacji:
Journal Article
MeSH Terms:
Cysts*/drug therapy
Polycystic Kidney Diseases*/metabolism
Polycystic Kidney, Autosomal Dominant*/drug therapy
Polycystic Kidney, Autosomal Dominant*/genetics
Polycystic Kidney, Autosomal Dominant*/metabolism
TRPP Cation Channels/*metabolism
Animals ; Cell Proliferation ; Disease Models, Animal ; Kidney/metabolism ; Mice ; Mice, Transgenic ; Suramin/pharmacology ; Suramin/therapeutic use ; TRPP Cation Channels/genetics
SCR Disease Name:
Potter Type III Polycystic Kidney Disease
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Paper-Based Detection Device for Microenvironment Examination: Measuring Neurotransmitters and Cytokines in the Mice Acupoint.
Autorzy:
Hsiao IH; Department of Neurosurgery, China Medical University Hospital, Taichung 404332, Taiwan.
Liao HY; School of Post-Baccalaureate Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404333, Taiwan.
Cheng CM; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.
Yen CM; Department of Anesthesiology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 42743, Taiwan.; School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien 97004, Taiwan.
Lin YW; Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 404333, Taiwan.
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Źródło:
Cells [Cells] 2022 Sep 14; Vol. 11 (18). Date of Electronic Publication: 2022 Sep 14.
Typ publikacji:
Journal Article
MeSH Terms:
Acupuncture Points*
Cytokines*
Animals ; Mice ; Adenosine Triphosphate ; Glutamic Acid ; Histamine ; Interleukin-1beta ; Interleukin-6 ; Neurotransmitter Agents ; Substance P ; Suramin
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differences in Transporters Rather than Drug Targets Are the Principal Determinants of the Different Innate Sensitivities of Trypanosoma congolense and Trypanozoon Subgenus Trypanosomes to Diamidines and Melaminophenyl Arsenicals.
Autorzy:
Ungogo MA; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.; Department of Veterinary Pharmacology and Toxicology, Ahmadu Bello University, Zaria 810107, Kaduna State, Nigeria.
Campagnaro GD; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Alghamdi AH; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Natto MJ; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
de Koning HP; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Mar 05; Vol. 23 (5). Date of Electronic Publication: 2022 Mar 05.
Typ publikacji:
Journal Article
MeSH Terms:
Arsenicals*
Trypanocidal Agents*/pharmacology
Trypanosoma*
Trypanosoma congolense*/metabolism
Animals ; Membrane Transport Proteins ; Pentamidine/metabolism ; Pentamidine/pharmacology ; Suramin/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Suramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A.
Autorzy:
Ren P; Unit of Anti-infective Research, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 320 Yueyang Road, 200031, Shanghai, China.; Laboratory of Viral Pathogenesis, Institut Pasteur, 28 Rue du Docteur Roux, 75724, Paris, France.
Zheng Y; Unit of Anti-infective Research, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 320 Yueyang Road, 200031, Shanghai, China.
Wang W; HONZ Pharma, 26FL, Dongshan Square, 69 Xian Lie Zhong Rd, 510095, Guangzhou, China.
Hong L; HONZ Pharma, 26FL, Dongshan Square, 69 Xian Lie Zhong Rd, 510095, Guangzhou, China.
Delpeyroux F; Unit of Biology of Enteric Viruses, Institut Pasteur, 25 Rue du Docteur Roux, 75724, Paris, France.; INSERM U994, Institut National de Santé et de La Recherche Médicale, Paris, France.
Arenzana-Seisdedos F; Laboratory of Viral Pathogenesis, Institut Pasteur, 28 Rue du Docteur Roux, 75724, Paris, France.
Altmeyer R; Unit of Anti-infective Research, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 320 Yueyang Road, 200031, Shanghai, China.; Shandong University-Helmholtz Institute of Biotechnology, 168 Zhuzhou Road, 266101, Qingdao, Shandong, China.; Qingdao Municipal Center for Disease Control &Prevention, 175 Shandong Road, 266033, Qingdao, China.
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Źródło:
Scientific reports [Sci Rep] 2017 Feb 20; Vol. 7, pp. 42902. Date of Electronic Publication: 2017 Feb 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Capsid Proteins/*metabolism
Enterovirus/*physiology
Suramin/*metabolism
Animals ; Capsid Proteins/chemistry ; Capsid Proteins/genetics ; Chlorocebus aethiops ; Enterovirus/classification ; Enterovirus/genetics ; Genotype ; Half-Life ; Humans ; Macaca fascicularis ; Mutagenesis ; Phylogeny ; Suramin/chemistry ; Suramin/pharmacology ; Vero Cells ; Virus Replication/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The effect of suramin on inhibiting fibroblast proliferation and preventing epidural fibrosis after laminectomy in rats.
Autorzy:
Dai J; Department of Orthopedics, Clinical Medical College of Yangzhou University, Orthopaedic Institute, Subei People's Hospital of Jiangsu Province, Yangzhou, 225001, China.
Li X; Department of Orthopedics, Clinical Medical College of Yangzhou University, Orthopaedic Institute, Subei People's Hospital of Jiangsu Province, Yangzhou, 225001, China.
Yan L; Department of Orthopedics, Clinical Medical College of Yangzhou University, Orthopaedic Institute, Subei People's Hospital of Jiangsu Province, Yangzhou, 225001, China.
Chen H; Department of Orthopedics, Clinical Medical College of Yangzhou University, Orthopaedic Institute, Subei People's Hospital of Jiangsu Province, Yangzhou, 225001, China.
He J; Department of Orthopedics, Clinical Medical College of Yangzhou University, Orthopaedic Institute, Subei People's Hospital of Jiangsu Province, Yangzhou, 225001, China.
Wang S; Department of Orthopedics, Clinical Medical College of Yangzhou University, Orthopaedic Institute, Subei People's Hospital of Jiangsu Province, Yangzhou, 225001, China.
Wang J; Department of Orthopedics, Clinical Medical College of Yangzhou University, Orthopaedic Institute, Subei People's Hospital of Jiangsu Province, Yangzhou, 225001, China. .
Sun Y; Department of Orthopedics, Clinical Medical College of Yangzhou University, Orthopaedic Institute, Subei People's Hospital of Jiangsu Province, Yangzhou, 225001, China. .
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Źródło:
Journal of orthopaedic surgery and research [J Orthop Surg Res] 2016 Oct 01; Vol. 11 (1), pp. 108. Date of Electronic Publication: 2016 Oct 01.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Proliferation/*drug effects
Epidural Space/*drug effects
Fibroblasts/*drug effects
Laminectomy/*adverse effects
Suramin/*therapeutic use
Animals ; Cell Proliferation/physiology ; Cell Survival/drug effects ; Cell Survival/physiology ; Cells, Cultured ; Dose-Response Relationship, Drug ; Epidural Space/pathology ; Epidural Space/surgery ; Fibroblasts/pathology ; Fibrosis/pathology ; Fibrosis/prevention & control ; Laminectomy/trends ; Rats ; Rats, Sprague-Dawley ; Suramin/pharmacology ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 1882

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