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Tytuł:: On the different experimental manifestations of two-state 'induced-fit' binding of drugs to their cellular targets.
Autorzy:: Vauquelin G; Department of Molecular and Biochemical Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.
Van Liefde I; Department of Molecular and Biochemical Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.
Swinney DC; Institute for Rare and Neglected Diseases Drug Discovery, Mountain View, CA, USA.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2016 Apr; Vol. 173 (8), pp. 1268-85. Date of Electronic Publication: 2016 Mar 15.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Angiotensin II Type 1 Receptor Blockers/*pharmacology
Receptor, Angiotensin, Type 1/*metabolism
Angiotensin II Type 1 Receptor Blockers/chemistry ; Animals ; Binding Sites/drug effects ; Humans ; Ligands

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Skocz do pozycji: 7.

Tytuł:: Correction: Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B.
Autorzy:: Fletcher SP
Chin DJ
Gruenbaum L
Bitter H
Rasmussen E
Ravindran P
Swinney DC
Birzele F
Schmucki R
Lorenz SH
Kopetzki E
Carter J
Triyatni M
Thampi LM
Yang J
AlDeghaither D
Murreddu MG
Cote P
Menne S; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2016 Mar 29; Vol. 12 (3), pp. e1005541. Date of Electronic Publication: 2016 Mar 29 (Print Publication: 2016).
Typ publikacji:: Published Erratum

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Tytuł:: A Four-Point Screening Method for Assessing Molecular Mechanism of Action (MMOA) Identifies Tideglusib as a Time-Dependent Inhibitor of Trypanosoma brucei GSK3β.
Autorzy:: Swinney ZT; Institute for Rare and Neglected Diseases Drug Discovery, Mountain View, California, United States of America.
Haubrich BA; Institute for Rare and Neglected Diseases Drug Discovery, Mountain View, California, United States of America.
Xia S; Institute for Rare and Neglected Diseases Drug Discovery, Mountain View, California, United States of America.
Ramesha C; Institute for Rare and Neglected Diseases Drug Discovery, Mountain View, California, United States of America.
Gomez SR; Institute for Rare and Neglected Diseases Drug Discovery, Mountain View, California, United States of America.
Guyett P; Department of Cellular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America.
Mensa-Wilmot K; Department of Cellular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America.
Swinney DC; Institute for Rare and Neglected Diseases Drug Discovery, Mountain View, California, United States of America.; Pokaż więcej
Źródło:: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2016 Mar 04; Vol. 10 (3), pp. e0004506. Date of Electronic Publication: 2016 Mar 04 (Print Publication: 2016).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Drug Evaluation, Preclinical/*methods
Enzyme Inhibitors/*pharmacology
Glycogen Synthase Kinase 3/*antagonists & inhibitors
Thiadiazoles/*pharmacology
Trypanosoma brucei brucei/*enzymology
Glycogen Synthase Kinase 3 beta ; Parasitic Sensitivity Tests ; Time Factors ; Trypanosoma brucei brucei/drug effects ; Trypanosoma brucei brucei/growth & development

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Skocz do pozycji: 9.

Tytuł:: Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B.
Autorzy:: Fletcher SP; Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America.
Chin DJ; Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America.
Gruenbaum L; Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America.
Bitter H; Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America.
Rasmussen E; Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America.
Ravindran P; Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America.
Swinney DC; Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America.
Birzele F; Roche Pharma Research & Early Development, Roche Innovation Center Penzberg, Penzberg, Germany.
Schmucki R; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Lorenz SH; Roche Pharma Research & Early Development, Roche Innovation Center Penzberg, Penzberg, Germany.
Kopetzki E; Roche Pharma Research & Early Development, Roche Innovation Center Penzberg, Penzberg, Germany.
Carter J; Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America.
Triyatni M; Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Thampi LM; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, United States of America.
Yang J; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, United States of America.
AlDeghaither D; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, United States of America.
Murreddu MG
Cote P; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, United States of America.
Menne S; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, United States of America.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2015 Sep 09; Vol. 11 (9), pp. e1005103. Date of Electronic Publication: 2015 Sep 09 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Transcription, Genetic*
Hepatitis B Virus, Woodchuck/*immunology
Hepatitis B, Chronic/*veterinary
Immunity, Cellular/*drug effects
Immunologic Factors/*therapeutic use
Interferon-alpha/*therapeutic use
Liver/*metabolism
Animals ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Antiviral Agents/metabolism ; Antiviral Agents/therapeutic use ; Biomarkers/blood ; Biomarkers/metabolism ; Biopsy ; Dose-Response Relationship, Drug ; Gene Expression Profiling ; Hepatitis B Virus, Woodchuck/drug effects ; Hepatitis B, Chronic/drug therapy ; Hepatitis B, Chronic/metabolism ; Hepatitis B, Chronic/virology ; Immunologic Factors/administration & dosage ; Immunologic Factors/genetics ; Immunologic Factors/metabolism ; Interferon-alpha/administration & dosage ; Interferon-alpha/genetics ; Interferon-alpha/metabolism ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Killer Cells, Natural/pathology ; Liver/immunology ; Liver/pathology ; Liver/virology ; Male ; Marmota ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/adverse effects ; Recombinant Proteins/metabolism ; Recombinant Proteins/therapeutic use ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes/pathology ; Viral Load/drug effects