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Tytuł :
Comparative Connectomics Reveals How Partner Identity, Location, and Activity Specify Synaptic Connectivity in Drosophila.
Autorzy :
Valdes-Aleman J; Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA; Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
Fetter RD; Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA.
Sales EC; Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA.
Heckman EL; Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA.
Venkatasubramanian L; Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
Doe CQ; Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA.
Landgraf M; Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
Cardona A; Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA; Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Zlatic M; Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA; Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address: .
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Źródło :
Neuron [Neuron] 2021 Jan 06; Vol. 109 (1), pp. 105-122.e7. Date of Electronic Publication: 2020 Oct 28.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Connectome/*methods
Interneurons/*metabolism
Nerve Net/*metabolism
Synapses/*metabolism
Animals ; Animals, Genetically Modified ; Drosophila melanogaster ; Interneurons/chemistry ; Nerve Net/chemistry ; Optogenetics/methods ; Synapses/chemistry ; Synapses/genetics
Czasopismo naukowe
Tytuł :
Synaptic mitochondrial dysfunction and septin accumulation are linked to complement-mediated synapse loss in an Alzheimer's disease animal model.
Autorzy :
Györffy BA; ELTE NAP Neuroimmunology Research Group, Department of Biochemistry, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.; Laboratory of Proteomics, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.
Tóth V; Laboratory of Proteomics, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.; Department of Biochemistry, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.
Török G; Molecular Cell Biology Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences Centre of Excellence, Budapest, Hungary.; Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Gulyássy P; MS Proteomics Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Budapest, Hungary.
Kovács RÁ; Department of Biochemistry, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.
Vadászi H; Department of Biochemistry, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.
Micsonai A; ELTE NAP Neuroimmunology Research Group, Department of Biochemistry, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.; Department of Biochemistry, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.
Tóth ME; Institute of Biochemistry, Biological Research Centre, Szeged, Hungary.
Sántha M; Institute of Biochemistry, Biological Research Centre, Szeged, Hungary.
Homolya L; Molecular Cell Biology Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences Centre of Excellence, Budapest, Hungary.
Drahos L; MS Proteomics Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Budapest, Hungary.
Juhász G; Laboratory of Proteomics, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.; CRU Hungary Ltd., Göd, Hungary.
Kékesi KA; ELTE NAP Neuroimmunology Research Group, Department of Biochemistry, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.; Laboratory of Proteomics, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.; Department of Physiology and Neurobiology, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary.
Kardos J; ELTE NAP Neuroimmunology Research Group, Department of Biochemistry, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary. .; Department of Biochemistry, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2020 Dec; Vol. 77 (24), pp. 5243-5258. Date of Electronic Publication: 2020 Feb 07.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*genetics
Amyloid/*metabolism
Proteome/*genetics
Synapses/*genetics
Alzheimer Disease/pathology ; Amyloid/toxicity ; Amyloidogenic Proteins/genetics ; Animals ; Disease Models, Animal ; Gene Expression Regulation/genetics ; Humans ; Mice ; Microglia/metabolism ; Microglia/pathology ; Mitochondria/genetics ; Mitochondria/pathology ; Oligopeptides/genetics ; Plaque, Amyloid/genetics ; Plaque, Amyloid/pathology ; Septins/genetics ; Synapses/metabolism ; Synapses/pathology ; Synaptosomes/metabolism ; Synaptosomes/pathology
Czasopismo naukowe
Tytuł :
Lymphocyte predominant cells of nodular lymphocyte predominant Hodgkin lymphoma interact with rosetting T cells in an immunological synapse.
Autorzy :
Bein J; Dr. Senckenberg Institute of Pathology, Goethe University, Frankfurt am Main, Germany.
Thurner L; Department of Internal Medicine I and José Carreras Center for Immuno- and Gene Therapy, Saarland University Medical School, Homburg/Saar, Germany.
Hansmann ML; Dr. Senckenberg Institute of Pathology, Goethe University, Frankfurt am Main, Germany.; Frankfurt Institute of Advanced Studies, Frankfurt am Main, Germany.
Hartmann S; Dr. Senckenberg Institute of Pathology, Goethe University, Frankfurt am Main, Germany.
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Źródło :
American journal of hematology [Am J Hematol] 2020 Dec; Vol. 95 (12), pp. 1495-1502. Date of Electronic Publication: 2020 Sep 03.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes*/immunology
B-Lymphocytes*/pathology
Hodgkin Disease*/immunology
Hodgkin Disease*/pathology
Immunological Synapses*/immunology
Immunological Synapses*/pathology
Moraxellaceae Infections*/immunology
Moraxellaceae Infections*/pathology
Antigens, Differentiation/*immunology
Moraxella/*immunology
Female ; Humans ; Male ; Retrospective Studies ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/pathology
Czasopismo naukowe
Tytuł :
Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer's disease.
Autorzy :
Nakamura T; Departments of Molecular Medicine and Neuroscience, and Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA 92037, USA. .; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121, USA.
Oh CK; Departments of Molecular Medicine and Neuroscience, and Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121, USA.
Liao L; Departments of Molecular Medicine and Neuroscience, and Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Zhang X; Departments of Molecular Medicine and Neuroscience, and Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121, USA.
Lopez KM; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121, USA.
Gibbs D; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.
Deal AK; Departments of Molecular Medicine and Neuroscience, and Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Scott HR; Departments of Molecular Medicine and Neuroscience, and Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Spencer B; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.
Masliah E; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.
Rissman RA; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.; VA San Diego Healthcare System, San Diego, CA 92161, USA.
Yates JR 3rd; Departments of Molecular Medicine and Neuroscience, and Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Lipton SA; Departments of Molecular Medicine and Neuroscience, and Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA 92037, USA. .; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121, USA.; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jan 15; Vol. 371 (6526). Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*enzymology
Cyclin-Dependent Kinase 5/*metabolism
Dynamins/*metabolism
Nitric Oxide/*metabolism
Nitric Oxide Synthase/*metabolism
Synapses/*enzymology
Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Animals ; Cysteine/genetics ; Cysteine/metabolism ; Disease Models, Animal ; HEK293 Cells ; Humans ; Mice ; Mice, Transgenic ; Mutation ; Nitroarginine/pharmacology ; Oxidation-Reduction ; Protein Processing, Post-Translational/drug effects ; Synapses/pathology ; Ubiquitin Thiolesterase/genetics ; Ubiquitin Thiolesterase/metabolism
Czasopismo naukowe
Tytuł :
A Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation.
Autorzy :
Rizalar FS; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Roosen DA; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Haucke V; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany; Faculty of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany. Electronic address: .
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Źródło :
Neuron [Neuron] 2021 Jan 06; Vol. 109 (1), pp. 27-41. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Neurogenesis/*physiology
Presynaptic Terminals/*metabolism
Protein Transport/*physiology
Synapses/*metabolism
Animals ; Humans ; Presynaptic Terminals/ultrastructure ; Synapses/ultrastructure ; Synaptic Transmission/physiology ; Synaptic Vesicles/metabolism ; Synaptic Vesicles/ultrastructure
Czasopismo naukowe
Tytuł :
Relocation of an Extrasynaptic GABA A Receptor to Inhibitory Synapses Freezes Excitatory Synaptic Strength and Preserves Memory.
Autorzy :
Davenport CM; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Rajappa R; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Katchan L; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Taylor CR; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Tsai MC; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Smith CM; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
de Jong JW; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Arnold DB; Department of Biology, Section of Molecular and Computational Biology, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA.
Lammel S; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Kramer RH; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2021 Jan 06; Vol. 109 (1), pp. 123-134.e4. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Excitatory Postsynaptic Potentials/*physiology
Inhibitory Postsynaptic Potentials/*physiology
Memory/*physiology
Neuronal Plasticity/*physiology
Receptors, GABA-A/*metabolism
Synapses/*metabolism
Animals ; Female ; Hippocampus/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptors, GABA-A/genetics ; Reversal Learning/physiology ; Synapses/genetics
Czasopismo naukowe
Tytuł :
Synaptic polarity and sign-balance prediction using gene expression data in the Caenorhabditis elegans chemical synapse neuronal connectome network.
Autorzy :
Fenyves BG; Department of Molecular Biology, Semmelweis University, Budapest, Hungary.; Department of Emergency Medicine, Semmelweis University, Budapest, Hungary.
Szilágyi GS; Department of Molecular Biology, Semmelweis University, Budapest, Hungary.
Vassy Z; Department of Molecular Biology, Semmelweis University, Budapest, Hungary.
Sőti C; Department of Molecular Biology, Semmelweis University, Budapest, Hungary.
Csermely P; Department of Molecular Biology, Semmelweis University, Budapest, Hungary.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2020 Dec 21; Vol. 16 (12), pp. e1007974. Date of Electronic Publication: 2020 Dec 21 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Connectome*
Gene Expression*
Caenorhabditis elegans/*physiology
Neurons/*physiology
Synapses/*physiology
Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Neurons/metabolism ; Synapses/metabolism
Czasopismo naukowe
Tytuł :
LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia.
Autorzy :
Henneberger C; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany. Electronic address: .
Bard L; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Panatier A; INSERM U1215, Neurocentre Magendie, 33000 Bordeaux, France; Université de Bordeaux, 33000 Bordeaux, France; Interdisciplinary Institute for Neuroscience, CNRS UMR 5297, 33000 Bordeaux, France.
Reynolds JP; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Kopach O; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Medvedev NI; Life Sciences, The Open University, Milton Keynes MK7 6AA, UK.
Minge D; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Herde MK; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Anders S; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Kraev I; Life Sciences, The Open University, Milton Keynes MK7 6AA, UK.
Heller JP; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Rama S; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Zheng K; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Jensen TP; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Sanchez-Romero I; Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria.
Jackson CJ; Research School of Chemistry, Australian National University, Acton, ACT 2601, Australia.
Janovjak H; Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria; EMBL Australia, Australian Regenerative Medicine Institute, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, VIC 3800, Australia.
Ottersen OP; Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway; Karolinska Institutet, 171 77 Stockholm, Sweden.
Nagelhus EA; Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.
Oliet SHR; INSERM U1215, Neurocentre Magendie, 33000 Bordeaux, France; Université de Bordeaux, 33000 Bordeaux, France.
Stewart MG; Life Sciences, The Open University, Milton Keynes MK7 6AA, UK. Electronic address: .
Nägerl UV; Université de Bordeaux, 33000 Bordeaux, France; Interdisciplinary Institute for Neuroscience, CNRS UMR 5297, 33000 Bordeaux, France. Electronic address: .
Rusakov DA; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Dec 09; Vol. 108 (5), pp. 919-936.e11. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*metabolism
Glutamic Acid/*metabolism
Long-Term Potentiation/*physiology
Synapses/*metabolism
Animals ; Astrocytes/ultrastructure ; Female ; Imaging, Three-Dimensional/methods ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Organ Culture Techniques ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Synapses/ultrastructure
Czasopismo naukowe
Tytuł :
Mesophasic organization of GABA A receptors in hippocampal inhibitory synapses.
Autorzy :
Liu YT; Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China.; CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Tao CL; Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China.; CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Interdisciplinary Center for Brain Information, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China.
Zhang X; Interdisciplinary Center for Brain Information, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China.
Xia W; School of Mathematical Sciences, Jiangsu University, Zhenjiang, China.
Shi DQ; CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Qi L; CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Xu C; Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China.
Sun R; Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China.
Li XW; Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China.
Lau PM; CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. .; Interdisciplinary Center for Brain Information, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China. .
Zhou ZH; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, USA. .; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA. .
Bi GQ; Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China. .; CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. .; Interdisciplinary Center for Brain Information, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China. .; CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. .
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Źródło :
Nature neuroscience [Nat Neurosci] 2020 Dec; Vol. 23 (12), pp. 1589-1596. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Hippocampus/*metabolism
Receptors, GABA-A/*metabolism
Synapses/*metabolism
Animals ; Computer Simulation ; Cryoelectron Microscopy ; Entropy ; Excitatory Postsynaptic Potentials ; Female ; Hippocampus/ultrastructure ; Membrane Proteins/metabolism ; Nerve Net/metabolism ; Nerve Net/ultrastructure ; Neural Inhibition ; Neuronal Plasticity/physiology ; Neurotransmitter Agents/metabolism ; Patch-Clamp Techniques ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; Synapses/ultrastructure ; Synaptic Vesicles/metabolism
Czasopismo naukowe
Tytuł :
Synapse and Receptor Alterations in Two Different S100B-Induced Glaucoma-Like Models.
Autorzy :
Benning L; Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Reinehr S; Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Grotegut P; Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Kuehn S; Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Stute G; Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Dick HB; Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Joachim SC; Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 23; Vol. 21 (19). Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article
MeSH Terms :
Autoimmune Diseases/*immunology
Glaucoma/*immunology
Receptors, GABA/*immunology
Receptors, N-Methyl-D-Aspartate/*immunology
S100 Calcium Binding Protein beta Subunit/*toxicity
Synapses/*immunology
Animals ; Autoimmune Diseases/chemically induced ; Autoimmune Diseases/pathology ; Disease Models, Animal ; Glaucoma/chemically induced ; Glaucoma/pathology ; Intraocular Pressure/drug effects ; Male ; Optic Nerve/immunology ; Optic Nerve/pathology ; Rats ; Rats, Inbred Lew ; Rats, Wistar ; Retinal Ganglion Cells/immunology ; Retinal Ganglion Cells/pathology ; S100 Calcium Binding Protein beta Subunit/immunology ; Synapses/pathology
Czasopismo naukowe
Tytuł :
Synaptic secretion from human natural killer cells is diverse and includes supramolecular attack particles.
Autorzy :
Ambrose AR; The Lydia Becker Institute of Immunology and Inflammation, University of Manchester, M13 9NT Manchester, United Kingdom.
Hazime KS; The Lydia Becker Institute of Immunology and Inflammation, University of Manchester, M13 9NT Manchester, United Kingdom.
Worboys JD; The Lydia Becker Institute of Immunology and Inflammation, University of Manchester, M13 9NT Manchester, United Kingdom.
Niembro-Vivanco O; The Lydia Becker Institute of Immunology and Inflammation, University of Manchester, M13 9NT Manchester, United Kingdom.
Davis DM; The Lydia Becker Institute of Immunology and Inflammation, University of Manchester, M13 9NT Manchester, United Kingdom .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 22; Vol. 117 (38), pp. 23717-23720. Date of Electronic Publication: 2020 Sep 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Killer Cells, Natural*/chemistry
Killer Cells, Natural*/immunology
Killer Cells, Natural*/metabolism
Synapses*/chemistry
Synapses*/immunology
Synapses*/metabolism
Granzymes/metabolism ; Humans ; Perforin/metabolism ; T-Lymphocytes, Cytotoxic/chemistry ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/metabolism ; Thrombospondin 1/metabolism
Czasopismo naukowe
Tytuł :
Mechanisms Underlying Enhancement of Spontaneous Glutamate Release by Group I mGluRs at a Central Auditory Synapse.
Autorzy :
Peng K; Department of Anatomy and Neurobiology, Hearing Research Group, College of Medicine, Northeast Ohio Medical University, Rootstown, Ohio 44272.
Wang X; Department of Biomedical Science, Program in Neuroscience, Florida State University College of Medicine, Tallahassee, Florida 32306.
Wang Y; Department of Biomedical Science, Program in Neuroscience, Florida State University College of Medicine, Tallahassee, Florida 32306.
Li D; Department of Cell and Molecular Biology, Brain Institute, Tulane University, New Orleans, Louisiana 70118.
Huang H; Department of Cell and Molecular Biology, Brain Institute, Tulane University, New Orleans, Louisiana 70118.
Lu Y; Department of Anatomy and Neurobiology, Hearing Research Group, College of Medicine, Northeast Ohio Medical University, Rootstown, Ohio 44272 .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Sep 09; Vol. 40 (37), pp. 7027-7042. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Glutamic Acid/*metabolism
Receptors, Metabotropic Glutamate/*metabolism
Synapses/*metabolism
Trapezoid Body/*metabolism
Animals ; Excitatory Amino Acid Agonists/pharmacology ; Excitatory Postsynaptic Potentials ; Female ; Glycine/analogs & derivatives ; Glycine/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Receptors, Metabotropic Glutamate/agonists ; Resorcinols/pharmacology ; Sodium Channel Blockers/pharmacology ; Sound Localization ; Synapses/drug effects ; Synapses/physiology ; Tetrodotoxin/pharmacology ; Trapezoid Body/cytology ; Trapezoid Body/physiology
Czasopismo naukowe
Tytuł :
Emodin protected against synaptic impairment and oxidative stress induced by fluoride in SH-SY5Y cells by modulating ERK1/2/Nrf2/HO-1 pathway.
Autorzy :
Lai C; Clinical Research Center, The First Affliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Chen Q; Clinical Research Center, The First Affliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Ding Y; Clinical Research Center, The First Affliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Liu H; Department of Anesthesiology, Tongren Municipal People's Hospital, Tongren, Guizhou, China.
Tang Z; Clinical Research Center, The First Affliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2020 Sep; Vol. 35 (9), pp. 922-929. Date of Electronic Publication: 2020 Apr 15.
Typ publikacji :
Journal Article
MeSH Terms :
Emodin/*pharmacology
Fluorides/*toxicity
MAP Kinase Signaling System/*drug effects
NF-E2-Related Factor 2/*metabolism
Neuroprotective Agents/*pharmacology
Oxidative Stress/*drug effects
Synapses/*drug effects
Antioxidants/metabolism ; Apoptosis/drug effects ; Cell Line, Tumor ; Humans ; Neuroblastoma/metabolism ; Neurotoxicity Syndromes/metabolism ; Neurotoxicity Syndromes/prevention & control ; Reactive Oxygen Species/metabolism ; Synapses/metabolism ; Synapses/pathology ; Synaptophysin/metabolism
Czasopismo naukowe
Tytuł :
Tau is not necessary for amyloid-β-induced synaptic and memory impairments.
Autorzy :
Puzzo D; Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.; Oasi Research Institute-IRCCS, Troina, Italy.
Argyrousi EK; Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and.; Department of Medicine, Columbia University, New York, New York, USA.
Staniszewski A; Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and.; Department of Medicine, Columbia University, New York, New York, USA.
Zhang H; Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and.; Department of Medicine, Columbia University, New York, New York, USA.
Calcagno E; Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and.; Department of Medicine, Columbia University, New York, New York, USA.
Zuccarello E; Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and.; Department of Medicine, Columbia University, New York, New York, USA.
Acquarone E; Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and.; Department of Medicine, Columbia University, New York, New York, USA.
Fa' M; Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and.; Department of Medicine, Columbia University, New York, New York, USA.
Li Puma DD; Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.; Fondazione Policlinico A. Gemelli-IRCCS, Rome, Italy.
Grassi C; Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.; Fondazione Policlinico A. Gemelli-IRCCS, Rome, Italy.
D'Adamio L; Department of Pharmacology, Physiology and Neuroscience, Rutgers University, Newark, New Jersey, USA.
Kanaan NM; Department of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, USA.
Fraser PE; Tanz Centre for Research in Neurodegenerative Diseases, and.; Department of Medical Biophysics, University of Toronto, Toronto, Canada.
Arancio O; Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, and.; Department of Medicine, Columbia University, New York, New York, USA.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Sep 01; Vol. 130 (9), pp. 4831-4844.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Long-Term Potentiation*
Synaptic Transmission*
Alzheimer Disease/*metabolism
Amyloid beta-Peptides/*metabolism
Synapses/*metabolism
tau Proteins/*metabolism
Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Animals ; Mice ; Mice, Knockout ; Synapses/genetics ; Synapses/pathology ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
Dependence of Generation of Hippocampal CA1 Slow Oscillations on Electrical Synapses.
Autorzy :
Xu Y; Institute and Key Laboratory of Brain Functional Genomics of The Chinese Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China.
Shen FY; Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Liu YZ; Institute and Key Laboratory of Brain Functional Genomics of The Chinese Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China.
Wang L; Institute and Key Laboratory of Brain Functional Genomics of The Chinese Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China.
Wang YW; Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Wang Z; Institute and Key Laboratory of Brain Functional Genomics of The Chinese Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China. .
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Źródło :
Neuroscience bulletin [Neurosci Bull] 2020 Jan; Vol. 36 (1), pp. 39-48. Date of Electronic Publication: 2019 Aug 29.
Typ publikacji :
Journal Article
MeSH Terms :
CA1 Region, Hippocampal/*drug effects
CA1 Region, Hippocampal/*physiology
Electrical Synapses/*drug effects
Electrical Synapses/*physiology
Action Potentials ; Animals ; Carbenoxolone/pharmacology ; Gap Junctions ; Hippocampus/drug effects ; Hippocampus/physiology ; Inhibitory Postsynaptic Potentials/drug effects ; Mefloquine/pharmacology ; Neurons/physiology ; Pyramidal Cells/physiology ; Rats ; Rats, Sprague-Dawley ; Synapses ; Synaptic Transmission/drug effects
Czasopismo naukowe
Tytuł :
Sex-Specific Vasopressin Signaling Buffers Stress-Dependent Synaptic Changes in Female Mice.
Autorzy :
Loewen SP; Hotchkiss Brain Institute and Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1.
Baimoukhametova DV; Hotchkiss Brain Institute and Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1.
Bains JS; Hotchkiss Brain Institute and Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1 .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Nov 11; Vol. 40 (46), pp. 8842-8852. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Synapses*
Vasopressins*
Stress, Psychological/*physiopathology
Animals ; Corticotropin-Releasing Hormone ; Cues ; Female ; Grooming ; In Vitro Techniques ; Male ; Mice ; Neuronal Plasticity ; Neurons ; Paraventricular Hypothalamic Nucleus/physiopathology ; Receptors, N-Methyl-D-Aspartate ; Receptors, Vasopressin/drug effects ; Sex Characteristics ; Smell ; Social Environment ; Stress, Psychological/psychology
Czasopismo naukowe
Tytuł :
[The neuronal protein Arc: a retrotransposon capsid domesticated to serve key synaptic functions].
Autorzy :
Albagli O; Inserm U1016, CNRS UMR8104, Institut Cochin, Groupe hospitalier Cochin-Port-Royal, bâtiment Cassini, 123 boulevard de Port-Royal, 75014 Paris, France.
Pelczar H; Inserm U1016, CNRS UMR8104, Institut Cochin, Groupe hospitalier Cochin-Port-Royal, bâtiment Cassini, 123 boulevard de Port-Royal, 75014 Paris, France.
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Transliterated Title :
La protéine neuronale Arc : une capside de rétrotransposon recyclée pour des fonctions clés dans les synapses.
Źródło :
Medecine sciences : M/S [Med Sci (Paris)] 2020 Nov; Vol. 36 (11), pp. 980-983. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Wiadomości
MeSH Terms :
Capsid Proteins/*physiology
Cytoskeletal Proteins/*physiology
Nerve Tissue Proteins/*physiology
Retroelements/*physiology
Synapses/*physiology
Animals ; Humans ; Neuronal Plasticity/genetics ; Neurons/metabolism ; Synapses/metabolism
Periodyk
Tytuł :
Protecting Connections from Synapse Elimination.
Autorzy :
Sell GL; Center for Neuroscience, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.
McAllister AK; Center for Neuroscience, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA. Electronic address: .
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Źródło :
Trends in neurosciences [Trends Neurosci] 2020 Nov; Vol. 43 (11), pp. 841-842. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Neurons*
Synapses*
Complement System Proteins ; Microglia
Czasopismo naukowe
Tytuł :
Hyaluronan regulates synapse formation and function in developing neural networks.
Autorzy :
Wilson E; Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
Knudson W; Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
Newell-Litwa K; Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Oct 05; Vol. 10 (1), pp. 16459. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article
MeSH Terms :
Hyaluronic Acid/*pharmacology
Nerve Net/*drug effects
Synapses/*drug effects
Cell Movement/drug effects ; Cells, Cultured ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; Extracellular Matrix/drug effects ; Extracellular Matrix/metabolism ; Humans ; Induced Pluripotent Stem Cells/drug effects ; Induced Pluripotent Stem Cells/metabolism ; Nerve Net/metabolism ; Neural Crest/drug effects ; Neural Crest/metabolism ; Neural Inhibition/drug effects ; Neurogenesis/drug effects ; Neurons/drug effects ; Neurons/metabolism ; Signal Transduction/drug effects ; Synapses/metabolism ; Synaptic Transmission/drug effects
Czasopismo naukowe

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