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Wyszukujesz frazę ""Synaptic Membranes"" wg kryterium: Temat


Tytuł :
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition.
Autorzy :
Man WK; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
Tahirbegi B; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, London, W12 0BZ, UK.
Vrettas MD; Department of Pharmacy, University of Naples 'Federico II', Naples, 80131, Italy.
Preet S; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
Ying L; National Heart and Lung Institute, Imperial College London, Molecular Sciences Research Hub, White City Campus, London, W12 0BZ, UK.
Vendruscolo M; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
De Simone A; Department of Pharmacy, University of Naples 'Federico II', Naples, 80131, Italy. .; Department of Life Sciences, Imperial College London, South Kensington, SW7 2AZ, UK. .
Fusco G; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 10; Vol. 12 (1), pp. 927. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lipids/*chemistry
Synaptic Membranes/*metabolism
Synaptic Vesicles/*metabolism
alpha-Synuclein/*chemistry
alpha-Synuclein/*metabolism
Humans ; Lipid Metabolism ; Protein Conformation ; Synaptic Membranes/chemistry ; Synaptic Membranes/genetics ; Synaptic Vesicles/chemistry ; Synaptic Vesicles/genetics ; alpha-Synuclein/genetics
Czasopismo naukowe
Tytuł :
Cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes.
Autorzy :
Wittig S; Interdisciplinary Research Centre HALOmem, Charles Tanford Protein Centre, Institute for Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle, Germany.
Ganzella M; Department for Neurobiology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Barth M; Interdisciplinary Research Centre HALOmem, Charles Tanford Protein Centre, Institute for Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle, Germany.
Kostmann S; Interdisciplinary Research Centre HALOmem, Charles Tanford Protein Centre, Institute for Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle, Germany.
Riedel D; Department for Neurobiology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Pérez-Lara Á; Department for Neurobiology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.; Department of Physical Chemistry, Faculty of Pharmacy, University of Granada, Granada, Spain.
Jahn R; Department for Neurobiology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Schmidt C; Interdisciplinary Research Centre HALOmem, Charles Tanford Protein Centre, Institute for Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 08; Vol. 12 (1), pp. 858. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mass Spectrometry*
Cross-Linking Reagents/*chemistry
Synaptic Membranes/*metabolism
Synaptic Vesicles/*metabolism
Animals ; Brain/metabolism ; Membrane Fusion ; Protein Binding ; Protein Interaction Maps ; Proteolipids ; Proteome/metabolism ; Rats ; Synaptic Membranes/ultrastructure ; Synaptic Vesicles/ultrastructure ; Synaptophysin/metabolism ; Vacuolar Proton-Translocating ATPases/metabolism ; Vesicle-Associated Membrane Protein 2/metabolism
Czasopismo naukowe
Tytuł :
Munc13 activates the Munc18-1/syntaxin-1 complex and enables Munc18-1 to prime SNARE assembly.
Autorzy :
Wang X; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Gong J; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Zhu L; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Wang S; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Yang X; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Xu Y; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Yang X; Key Laboratory of Cognitive Science, Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis & Treatment, Laboratory of Membrane Ion Channels and Medicine, College of Biomedical Engineering, South-Central University for Nationalities, Wuhan, China.
Ma C; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.; Institute of Brain Research, Huazhong University of Science and Technology, Wuhan, China.
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Źródło :
The EMBO journal [EMBO J] 2020 Aug 17; Vol. 39 (16), pp. e103631. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Munc18 Proteins*/chemistry
Munc18 Proteins*/genetics
Munc18 Proteins*/metabolism
Nerve Tissue Proteins*/chemistry
Nerve Tissue Proteins*/genetics
Nerve Tissue Proteins*/metabolism
SNARE Proteins*/chemistry
SNARE Proteins*/genetics
SNARE Proteins*/metabolism
Synaptic Membranes*/chemistry
Synaptic Membranes*/genetics
Synaptic Membranes*/metabolism
Syntaxin 1*/chemistry
Syntaxin 1*/genetics
Syntaxin 1*/metabolism
Animals ; HEK293 Cells ; Humans ; Mice ; Protein Domains ; Rats
Czasopismo naukowe
Tytuł :
HDAC6 regulates microtubule stability and clustering of AChRs at neuromuscular junctions.
Autorzy :
Osseni A; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Éric Poulin Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Ravel-Chapuis A; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Éric Poulin Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Thomas JL; Institut NeuroMyoGene, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5310, Institut National de la Santé et de la Recherche Médicale Unité 1217, Université de Lyon, Lyon, France.
Gache V; Institut NeuroMyoGene, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5310, Institut National de la Santé et de la Recherche Médicale Unité 1217, Université de Lyon, Lyon, France.
Schaeffer L; Institut NeuroMyoGene, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5310, Institut National de la Santé et de la Recherche Médicale Unité 1217, Université de Lyon, Lyon, France.; Centre de Biotechnologie Cellulaire, Hospices Civils de Lyon, Lyon, France.
Jasmin BJ; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Éric Poulin Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
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Źródło :
The Journal of cell biology [J Cell Biol] 2020 Aug 03; Vol. 219 (8).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Histone Deacetylase 6/*metabolism
Microtubules/*enzymology
Muscle Fibers, Skeletal/*enzymology
Neuromuscular Junction/*enzymology
Receptors, Cholinergic/*metabolism
Synaptic Membranes/*enzymology
Tubulin/*metabolism
Acetylation ; Animals ; Cell Line ; Histone Deacetylase 6/antagonists & inhibitors ; Histone Deacetylase 6/genetics ; Histone Deacetylase Inhibitors/pharmacology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Microtubules/drug effects ; Muscle Fibers, Skeletal/drug effects ; Neuromuscular Junction/drug effects ; Paxillin/metabolism ; Protein Processing, Post-Translational ; Protein Stability ; Synaptic Membranes/drug effects
Czasopismo naukowe
Tytuł :
Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices.
Autorzy :
Imig C; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany. Electronic address: .
López-Murcia FJ; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany.
Maus L; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany; Georg August University School of Science, Georg August University Göttingen, 37073 Göttingen, Germany.
García-Plaza IH; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany; Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences, 37077 Göttingen, Germany.
Mortensen LS; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany.
Schwark M; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany.
Schwarze V; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany.
Angibaud J; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, F-33000 Bordeaux, France.
Nägerl UV; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, F-33000 Bordeaux, France.
Taschenberger H; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany.
Brose N; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' University of Göttingen, 37073 Göttingen, Germany. Electronic address: .
Cooper BH; Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Dec 09; Vol. 108 (5), pp. 843-860.e8. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Excitatory Postsynaptic Potentials/*physiology
Hippocampus/*physiology
Hippocampus/*ultrastructure
Synaptic Membranes/*physiology
Synaptic Membranes/*ultrastructure
Animals ; Gene Knock-In Techniques/methods ; Mice ; Mice, Transgenic ; Microscopy, Electron/methods ; Microtomy/methods ; Organ Culture Techniques ; Protein Transport/physiology
Czasopismo naukowe
Tytuł :
Roles of DGKs in neurons: Postsynaptic functions?
Autorzy :
Barber CN; The Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD, 21205, USA.
Raben DM; The Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD, 21205, USA. Electronic address: .
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Źródło :
Advances in biological regulation [Adv Biol Regul] 2020 Jan; Vol. 75, pp. 100688. Date of Electronic Publication: 2019 Nov 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Endocytosis*
Diacylglycerol Kinase/*metabolism
Neurons/*enzymology
Synaptic Membranes/*enzymology
Synaptic Vesicles/*enzymology
Animals ; Diacylglycerol Kinase/genetics ; Humans ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Mice ; Phosphatidic Acids/genetics ; Phosphatidic Acids/metabolism ; Receptors, AMPA/genetics ; Receptors, AMPA/metabolism ; Synaptic Membranes/genetics ; Synaptic Vesicles/genetics
Czasopismo naukowe
Tytuł :
SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function.
Autorzy :
Ribeiro LF; VIB Center for Brain & Disease Research, Herestraat, Leuven, Belgium.; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Herestraat, Leuven, Belgium.
Verpoort B; VIB Center for Brain & Disease Research, Herestraat, Leuven, Belgium.; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Herestraat, Leuven, Belgium.
Nys J; VIB Center for Brain & Disease Research, Herestraat, Leuven, Belgium.; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Herestraat, Leuven, Belgium.
Vennekens KM; VIB Center for Brain & Disease Research, Herestraat, Leuven, Belgium.; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Herestraat, Leuven, Belgium.
Wierda KD; VIB Center for Brain & Disease Research, Herestraat, Leuven, Belgium.; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Herestraat, Leuven, Belgium.
de Wit J; VIB Center for Brain & Disease Research, Herestraat, Leuven, Belgium.; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Herestraat, Leuven, Belgium.
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Źródło :
PLoS biology [PLoS Biol] 2019 Oct 28; Vol. 17 (10), pp. e3000466. Date of Electronic Publication: 2019 Oct 28 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium-Binding Proteins/*genetics
Cerebral Cortex/*metabolism
Neural Cell Adhesion Molecules/*genetics
Neurons/*metabolism
Receptors, Cell Surface/*genetics
Synaptic Membranes/*metabolism
Synaptic Transmission/*genetics
Animals ; Calcium-Binding Proteins/metabolism ; Cell Polarity ; Cerebral Cortex/cytology ; Embryo, Mammalian ; Endocytosis ; Endosomes/metabolism ; Gene Expression Regulation ; HEK293 Cells ; Humans ; Mice ; Mice, Inbred C57BL ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Neural Cell Adhesion Molecules/metabolism ; Neurons/ultrastructure ; Primary Cell Culture ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Transport ; Rats ; Rats, Wistar ; Receptors, Cell Surface/metabolism ; Synaptic Membranes/ultrastructure ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABA A receptors.
Autorzy :
Limon A; Department of Psychiatry and Human Behavior. School of Medicine, University of California Irvine, Irvine, USA. .; Department of Neurology, Mitchel Center for Neurodegenerative Diseases, School of Medicine, University of Texas Medical Branch at Galveston, Galveston, USA. .
Delbruck E; Department of Psychiatry and Human Behavior. School of Medicine, University of California Irvine, Irvine, USA.
Yassine A; Department of Psychiatry and Human Behavior. School of Medicine, University of California Irvine, Irvine, USA.
Pandya D; Department of Neurology, Mitchel Center for Neurodegenerative Diseases, School of Medicine, University of Texas Medical Branch at Galveston, Galveston, USA.
Myers RM; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Barchas JD; Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA.
Lee F; Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA.
Schatzberg; Department of Psychiatry & Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
Watson SJ; Molecular and Behavioral Neurosciences Institute, University of Michigan, Ann Arbor, MI, USA.
Akil H; Molecular and Behavioral Neurosciences Institute, University of Michigan, Ann Arbor, MI, USA.
Bunney WE; Department of Psychiatry and Human Behavior. School of Medicine, University of California Irvine, Irvine, USA.
Vawter MP; Department of Psychiatry and Human Behavior. School of Medicine, University of California Irvine, Irvine, USA.
Sequeira A; Department of Psychiatry and Human Behavior. School of Medicine, University of California Irvine, Irvine, USA. .
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Źródło :
Translational psychiatry [Transl Psychiatry] 2019 Sep 05; Vol. 9 (1), pp. 218. Date of Electronic Publication: 2019 Sep 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Prefrontal Cortex/*drug effects
Receptors, GABA-A/*metabolism
Spermine/*pharmacology
Synapses/*drug effects
Synaptic Membranes/*drug effects
Humans ; Hydrogen-Ion Concentration ; Neurons/drug effects ; Neurons/metabolism ; Oocytes/drug effects ; Oocytes/metabolism ; Prefrontal Cortex/metabolism ; Synapses/metabolism ; Synaptic Membranes/metabolism
Czasopismo naukowe
Tytuł :
Neurotoxicity of HIV-1 Tat is attributed to its penetrating property.
Autorzy :
Tang X; Laboratory of Retrovirology, Division of Infectious Diseases, Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, 55 Claverick Street (Laboratory 414), Providence, RI, 02903, USA.
Lu H; Laboratory of Retrovirology, Division of Infectious Diseases, Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, 55 Claverick Street (Laboratory 414), Providence, RI, 02903, USA.
Ramratnam B; Laboratory of Retrovirology, Division of Infectious Diseases, Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, 55 Claverick Street (Laboratory 414), Providence, RI, 02903, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Aug 19; Vol. 10 (1), pp. 14002. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Dependovirus/*genetics
Exosomes/*genetics
Genetic Vectors/*genetics
Neurons/*metabolism
tat Gene Products, Human Immunodeficiency Virus/*genetics
Animals ; Brain/metabolism ; Brain/virology ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/virology ; Cell Line, Tumor ; Cell Survival/genetics ; Gene Expression ; Genetic Vectors/blood ; Genetic Vectors/pharmacokinetics ; HEK293 Cells ; Humans ; Injections, Intravenous ; Liver/metabolism ; Liver/virology ; Mice, Inbred BALB C ; Neurons/cytology ; Synaptic Membranes/metabolism ; Synaptic Membranes/virology ; Synaptophysin/genetics ; Synaptophysin/metabolism ; Transfection/methods ; tat Gene Products, Human Immunodeficiency Virus/blood ; tat Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
Synaptic Vesicles Having Large Contact Areas with the Presynaptic Membrane are Preferentially Hemifused at Active Zones of Frog Neuromuscular Junctions Fixed during Synaptic Activity.
Autorzy :
Jung JH; Department of Biology, Texas A&M University, College Station, TX 77845, USA. .; Department of Physics, Stanford University School of Humanities and Sciences, Stanford, CA 94309, USA. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 May 31; Vol. 20 (11). Date of Electronic Publication: 2019 May 31.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Synaptic Transmission*
Neuromuscular Junction/*metabolism
Synaptic Membranes/*metabolism
Synaptic Vesicles/*metabolism
Animals ; Anura ; Models, Biological ; Neuromuscular Junction/ultrastructure ; Synaptic Membranes/ultrastructure ; Synaptic Vesicles/ultrastructure
Czasopismo naukowe
Tytuł :
Syntaxin Clustering and Optogenetic Control for Synaptic Membrane Fusion.
Autorzy :
Li M; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan 646000, China.
Oh TJ; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Fan H; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Diao J; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address: .
Zhang K; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2020 Aug 07; Vol. 432 (17), pp. 4773-4782. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Qa-SNARE Proteins/*chemistry
Qa-SNARE Proteins/*metabolism
Synaptic Membranes/*physiology
Animals ; Humans ; Membrane Fusion ; Neurons/physiology ; Optogenetics ; Protein Multimerization ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Nanomachinery Organizing Release at Neuronal and Ribbon Synapses.
Autorzy :
Chakrabarti R; Molecular Architecture of Synapses Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany. .; Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37075 Göttingen, Germany. .; Collaborative Research Center 889 'Cellular Mechanisms of Sensory Processing', 37099 Göttingen, Germany. .
Wichmann C; Molecular Architecture of Synapses Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany. .; Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37075 Göttingen, Germany. .; Collaborative Research Center 889 'Cellular Mechanisms of Sensory Processing', 37099 Göttingen, Germany. .; Collaborative Research Center 1286 'Quantitative Synaptology', 37099 Göttingen, Germany. .; Auditory Neuroscience Group, Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Apr 30; Vol. 20 (9). Date of Electronic Publication: 2019 Apr 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Exocytosis*
Cytoskeleton/*metabolism
Sensory Receptor Cells/*metabolism
Synaptic Membranes/*metabolism
Synaptic Vesicles/*metabolism
Animals ; Cytoskeleton/ultrastructure ; Humans ; Sensory Receptor Cells/ultrastructure ; Synaptic Membranes/ultrastructure ; Synaptic Transmission ; Synaptic Vesicles/ultrastructure
Czasopismo naukowe
Tytuł :
RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation.
Autorzy :
Wu X; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Cai Q; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Shen Z; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Chen X; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Zeng M; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Du S; Department of Physics, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Zhang M; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Center of Systems Biology and Human Health, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2019 Mar 07; Vol. 73 (5), pp. 971-984.e5. Date of Electronic Publication: 2019 Jan 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Calcium Channels, N-Type/*metabolism
GTP-Binding Proteins/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Presynaptic Terminals/*metabolism
Synaptic Membranes/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Binding Sites ; Calcium Channels, N-Type/genetics ; GTP-Binding Proteins/genetics ; Intrinsically Disordered Proteins/genetics ; Intrinsically Disordered Proteins/metabolism ; Kinetics ; Membrane Microdomains/genetics ; Membrane Microdomains/metabolism ; Mice ; Protein Binding ; Protein Interaction Domains and Motifs ; Rats ; SNARE Proteins/genetics ; SNARE Proteins/metabolism ; Solubility ; Synaptic Membranes/genetics ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures.
Autorzy :
Moore YE; Department of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, United Kingdom.; Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111.
Deeb TZ; AstraZeneca-Tufts University Laboratory for Basic and Translational Neuroscience Research, Tufts University School of Medicine, Boston, MA 02111.
Chadchankar H; Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111.
Brandon NJ; AstraZeneca-Tufts University Laboratory for Basic and Translational Neuroscience Research, Tufts University School of Medicine, Boston, MA 02111.; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, MA 02451.
Moss SJ; Department of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, United Kingdom; .; Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111.; AstraZeneca-Tufts University Laboratory for Basic and Translational Neuroscience Research, Tufts University School of Medicine, Boston, MA 02111.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Oct 02; Vol. 115 (40), pp. 10166-10171. Date of Electronic Publication: 2018 Sep 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Epilepsy/*metabolism
Neurons/*metabolism
Seizures/*metabolism
Symporters/*metabolism
Synaptic Membranes/*metabolism
gamma-Aminobutyric Acid/*metabolism
Amino Acid Substitution ; Animals ; Epilepsy/genetics ; Epilepsy/pathology ; Gene Knock-In Techniques ; Mice ; Mutation, Missense ; Neurons/pathology ; Seizures/genetics ; Seizures/pathology ; Symporters/genetics ; Synaptic Membranes/genetics ; Synaptic Membranes/pathology ; gamma-Aminobutyric Acid/genetics
Czasopismo naukowe
Tytuł :
Cannabinoid type 2 receptors inhibit GABAA receptor-mediated currents in cerebellar Purkinje cells of juvenile mice.
Autorzy :
Sadanandan SM; Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.
Kreko-Pierce T; Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.
Khatri SN; Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.
Pugh JR; Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.; Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America.
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Źródło :
PloS one [PLoS One] 2020 May 21; Vol. 15 (5), pp. e0233020. Date of Electronic Publication: 2020 May 21 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Purkinje Cells/*physiology
Receptor, Cannabinoid, CB2/*genetics
Receptor, Cannabinoid, CB2/*metabolism
Receptors, GABA-A/*metabolism
Animals ; Cannabinoids/pharmacology ; Cyclohexanes/pharmacology ; Female ; Gene Knockout Techniques ; Male ; Mice ; Morpholines/pharmacology ; Patch-Clamp Techniques ; Quinolines/pharmacology ; Receptor, Cannabinoid, CB2/agonists ; Synaptic Membranes/physiology ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Lipids and phosphates at odds in synaptic depression.
Autorzy :
Omelchenko A; From the Department of Cell Biology and Neuroscience, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854.
Firestein BL; From the Department of Cell Biology and Neuroscience, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854 .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2018 Feb 02; Vol. 293 (5), pp. 1568-1569. Date of Electronic Publication: 2018 Feb 02.
Typ publikacji :
Journal Article
MeSH Terms :
Long-Term Synaptic Depression*
A Kinase Anchor Proteins/*metabolism
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism
Phospholipids/*metabolism
Synaptic Membranes/*metabolism
Animals ; Lipoylation ; Phosphorylation ; Protein Domains ; Protein Transport ; Rats ; Rats, Sprague-Dawley ; Spine/metabolism ; Spine/pathology ; Synaptic Membranes/pathology
Czasopismo naukowe
Tytuł :
Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer's disease.
Autorzy :
Goetzl EJ; Department of Medicine, University of California, San Francisco, San Francisco, California, USA.; Jewish Home of San Francisco, San Francisco, California, USA.
Abner EL; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
Jicha GA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
Kapogiannis D; Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland, USA.
Schwartz JB; Department of Medicine, University of California, San Francisco, San Francisco, California, USA.; Jewish Home of San Francisco, San Francisco, California, USA.; Department of Bioengineering, University of California, San Francisco, San Francisco, California, USA.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2018 Feb; Vol. 32 (2), pp. 888-893. Date of Electronic Publication: 2018 Jan 04.
Typ publikacji :
Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*blood
Cell Adhesion Molecules, Neuronal/*blood
Exosomes/*metabolism
Nerve Tissue Proteins/*blood
Neurons/*metabolism
Receptors, AMPA/*blood
Synaptic Membranes/*metabolism
Aged ; Alzheimer Disease/pathology ; C-Reactive Protein ; Exosomes/pathology ; Female ; Humans ; Male ; Neurons/pathology ; Synaptic Membranes/pathology
Czasopismo naukowe
Tytuł :
Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly.
Autorzy :
Anderson GR; Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA .; Department of Psychiatry and Behavioral Science, Nancy Pritzker Laboratory, Stanford University Medical School, Stanford, CA.
Maxeiner S; Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA.
Sando R; Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA.
Tsetsenis T; Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA.
Malenka RC; Department of Psychiatry and Behavioral Science, Nancy Pritzker Laboratory, Stanford University Medical School, Stanford, CA.
Südhof TC; Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA .
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Źródło :
The Journal of cell biology [J Cell Biol] 2017 Nov 06; Vol. 216 (11), pp. 3831-3846. Date of Electronic Publication: 2017 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms :
CA1 Region, Hippocampal/*metabolism
Entorhinal Cortex/*metabolism
Neurons/*metabolism
Presynaptic Terminals/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Receptors, Peptide/*metabolism
Synaptic Membranes/*metabolism
Animals ; Behavior, Animal ; CA1 Region, Hippocampal/pathology ; CA1 Region, Hippocampal/physiopathology ; Cells, Cultured ; Dendritic Spines/metabolism ; Dendritic Spines/pathology ; Entorhinal Cortex/pathology ; Entorhinal Cortex/physiopathology ; Fear ; Genotype ; Maze Learning ; Memory ; Mice, Mutant Strains ; Motor Activity ; Neurons/pathology ; Phenotype ; Presynaptic Terminals/pathology ; Receptors, G-Protein-Coupled/genetics ; Receptors, Peptide/genetics ; Rotarod Performance Test ; Smell ; Synaptic Membranes/pathology ; Synaptic Potentials ; Time Factors ; Transfection
Czasopismo naukowe
Tytuł :
Altered Synaptic Membrane Retrieval after Strong Stimulation of Cerebellar Granule Neurons in Cyclic GMP-Dependent Protein Kinase II (cGKII) Knockout Mice.
Autorzy :
Collado-Alsina A; Departamento de Bioquímica, Facultad de Veterinaria, Universidad Complutense, 28040 Madrid, Spain. .; Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain. .
Hofmann F; FOR 923, Institut für Pharmakologie und Toxikologie, Technische Universität München, Biedersteiner Str. 29, 80802 Munich, Germany. .
Sánchez-Prieto J; Departamento de Bioquímica, Facultad de Veterinaria, Universidad Complutense, 28040 Madrid, Spain. .; Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain. .
Torres M; Departamento de Bioquímica, Facultad de Veterinaria, Universidad Complutense, 28040 Madrid, Spain. .; Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2017 Oct 30; Vol. 18 (11). Date of Electronic Publication: 2017 Oct 30.
Typ publikacji :
Journal Article
MeSH Terms :
Cerebellum/*cytology
Cerebellum/*metabolism
Cyclic GMP/*metabolism
Neurons/*metabolism
Protein Kinases/*metabolism
Synaptic Membranes/*metabolism
Animals ; Endocytosis ; Exocytosis ; Fluorescent Antibody Technique ; Membrane Potentials ; Mice ; Mice, Knockout ; Molecular Imaging ; Neurons/ultrastructure ; Protein Kinases/genetics ; Secretory Vesicles/metabolism ; Synaptic Membranes/ultrastructure
Czasopismo naukowe
Tytuł :
Correlating Fluorescence and High-Resolution Scanning Electron Microscopy (HRSEM) for the study of GABA A receptor clustering induced by inhibitory synaptic plasticity.
Autorzy :
Orlando M; Neuroscience and Brain Technologies Department, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genoa, Italy.; Institute of Neurophysiology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Ravasenga T; Neuroscience and Brain Technologies Department, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genoa, Italy.
Petrini EM; Neuroscience and Brain Technologies Department, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genoa, Italy.
Falqui A; Nabla Lab, Biological and Environmental Sciences and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), 23955-6900, Thuwal, Saudi Arabia.
Marotta R; Electron Microscopy Facility, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genoa, Italy.
Barberis A; Neuroscience and Brain Technologies Department, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genoa, Italy. .
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Źródło :
Scientific reports [Sci Rep] 2017 Oct 23; Vol. 7 (1), pp. 13768. Date of Electronic Publication: 2017 Oct 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neuronal Plasticity*
Microscopy, Electron, Scanning/*methods
Microscopy, Fluorescence/*methods
Receptors, GABA-A/*chemistry
Receptors, GABA-A/*metabolism
Synapses/*physiology
Synaptic Membranes/*metabolism
Animals ; Hippocampus/physiology ; Hippocampus/ultrastructure ; Long-Term Potentiation ; Mice ; Mice, Inbred C57BL ; Synapses/ultrastructure ; Synaptic Membranes/ultrastructure
Czasopismo naukowe

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