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Wyszukujesz frazę ""Synaptic depression"" wg kryterium: Temat


Tytuł :
Hippocampal long-term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G-protein-gated inwardly rectifying potassium channel activity.
Autorzy :
Sánchez-Rodríguez I; NeuroPhysiology & Behavior Laboratory, Centro Regional de Investigaciones Biomédicas, School of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain.
Djebari S; NeuroPhysiology & Behavior Laboratory, Centro Regional de Investigaciones Biomédicas, School of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain.
Temprano-Carazo S; NeuroPhysiology & Behavior Laboratory, Centro Regional de Investigaciones Biomédicas, School of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain.
Vega-Avelaira D; Departamento de Ciencias Biomédicas Básicas, European University of Madrid, Madrid, Spain.
Jiménez-Herrera R; NeuroPhysiology & Behavior Laboratory, Centro Regional de Investigaciones Biomédicas, School of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain.
Iborra-Lázaro G; NeuroPhysiology & Behavior Laboratory, Centro Regional de Investigaciones Biomédicas, School of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain.
Yajeya J; Instituto de Neurociencias de Castilla y León, University of Salamanca, Salamanca, Spain.
Jiménez-Díaz L; NeuroPhysiology & Behavior Laboratory, Centro Regional de Investigaciones Biomédicas, School of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain.
Navarro-López JD; NeuroPhysiology & Behavior Laboratory, Centro Regional de Investigaciones Biomédicas, School of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain.
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Źródło :
Journal of neurochemistry [J Neurochem] 2020 May; Vol. 153 (3), pp. 362-376. Date of Electronic Publication: 2020 Jan 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloidosis/*metabolism
Excitatory Postsynaptic Potentials/*physiology
G Protein-Coupled Inwardly-Rectifying Potassium Channels/*metabolism
Hippocampus/*metabolism
Long-Term Synaptic Depression/*physiology
Memory Disorders/*metabolism
Amyloid beta-Peptides/toxicity ; Amyloidosis/chemically induced ; Animals ; Excitatory Postsynaptic Potentials/drug effects ; Hippocampus/drug effects ; Long-Term Synaptic Depression/drug effects ; Male ; Memory Disorders/chemically induced ; Mice ; Mice, Inbred C57BL ; Organ Culture Techniques ; Peptide Fragments/toxicity ; Potassium Channels, Inwardly Rectifying/metabolism ; Receptors, G-Protein-Coupled/metabolism
Czasopismo naukowe
Tytuł :
Early correction of synaptic long-term depression improves abnormal anxiety-like behavior in adult GluN2B-C456Y-mutant mice.
Autorzy :
Shin W; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Kim K; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Serraz B; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, Université PSL, CNRS, INSERM, Paris, France.
Cho YS; Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Korea.
Kim D; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea.
Kang M; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Lee EJ; Department of Neurology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea.
Lee H; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Bae YC; Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Korea.
Paoletti P; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, Université PSL, CNRS, INSERM, Paris, France.
Kim E; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.; Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea.
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Źródło :
PLoS biology [PLoS Biol] 2020 Apr 30; Vol. 18 (4), pp. e3000717. Date of Electronic Publication: 2020 Apr 30 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anxiety/*genetics
Hippocampus/*physiology
Long-Term Synaptic Depression/*physiology
Receptors, N-Methyl-D-Aspartate/*genetics
Animals ; Anxiety/physiopathology ; Behavior, Animal/drug effects ; Cycloserine/pharmacology ; Excitatory Postsynaptic Potentials/genetics ; Gene Knock-In Techniques ; Haploinsufficiency/genetics ; Heterozygote ; Hippocampus/metabolism ; Long-Term Synaptic Depression/drug effects ; Mice, Mutant Strains ; Mutation ; Nerve Tissue Proteins/metabolism ; Receptors, N-Methyl-D-Aspartate/agonists ; Receptors, N-Methyl-D-Aspartate/metabolism
Czasopismo naukowe
Tytuł :
Synapse-specific expression of mu opioid receptor long-term depression in the dorsomedial striatum.
Autorzy :
Muñoz B; Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. .
Haggerty DL; Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Atwood BK; Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. .; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Apr 29; Vol. 10 (1), pp. 7234. Date of Electronic Publication: 2020 Apr 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression Regulation*
Long-Term Synaptic Depression*
Corpus Striatum/*metabolism
Receptors, Opioid, mu/*biosynthesis
Synapses/*metabolism
Animals ; Corpus Striatum/cytology ; Male ; Mice ; Mice, Knockout ; Receptors, Opioid, mu/genetics ; Synapses/genetics
Czasopismo naukowe
Tytuł :
PSD-95 Serine 73 phosphorylation is not required for induction of NMDA-LTD.
Autorzy :
Nowacka A; Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Borczyk M; Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Salamian A; Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Wójtowicz T; Laboratory of Cell Biophysics, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Włodarczyk J; Laboratory of Cell Biophysics, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Radwanska K; Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland. .
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Źródło :
Scientific reports [Sci Rep] 2020 Feb 06; Vol. 10 (1), pp. 2054. Date of Electronic Publication: 2020 Feb 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism
Disks Large Homolog 4 Protein/*metabolism
Long-Term Synaptic Depression/*physiology
N-Methylaspartate/*metabolism
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives ; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology ; Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/antagonists & inhibitors ; Cells, Cultured ; Down-Regulation ; Hippocampus/cytology ; Hippocampus/metabolism ; Long-Term Synaptic Depression/drug effects ; Neurons ; Phosphorylation/drug effects ; Phosphorylation/physiology ; Post-Synaptic Density/metabolism ; Primary Cell Culture ; Rats ; Serine/metabolism ; Synaptic Potentials/drug effects ; Synaptic Potentials/physiology
Czasopismo naukowe
Tytuł :
Astrocytic Endocannabinoids Mediate Hippocampal Transient Heterosynaptic Depression.
Autorzy :
Smith NA; Division of Glia Disease and Therapeutics, Dept. of Neurosurgery, Center for Translational Neuromedicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA. .; Center for Neuroscience, Children's Research Institute, Children's National Medical Center, 111 Michigan Ave, Washington, NW, 20010, USA. .; George Washington University School of Medicine and Health Sciences, Washington, DC, 20052, USA. .
Bekar LK; Department of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada.
Nedergaard M; Division of Glia Disease and Therapeutics, Dept. of Neurosurgery, Center for Translational Neuromedicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA.
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Źródło :
Neurochemical research [Neurochem Res] 2020 Jan; Vol. 45 (1), pp. 100-108. Date of Electronic Publication: 2019 Jun 28.
Typ publikacji :
Journal Article
MeSH Terms :
Astrocytes/*metabolism
Endocannabinoids/*metabolism
Long-Term Synaptic Depression/*physiology
Synapses/*metabolism
Synaptic Transmission/*physiology
Animals ; Astrocytes/drug effects ; Endocannabinoids/antagonists & inhibitors ; Hippocampus/drug effects ; Hippocampus/metabolism ; Long-Term Synaptic Depression/drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Piperidines/pharmacology ; Pyrazoles/pharmacology ; Synapses/drug effects ; Synaptic Transmission/drug effects
Czasopismo naukowe
Tytuł :
Effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from Fmr1 knockout mice.
Autorzy :
Cooke SK; Section on Neuroadaptation and Protein Metabolism, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Russin J; Section on Neuroadaptation and Protein Metabolism, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Moulton K; Section on Neuroadaptation and Protein Metabolism, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Nadel J; Section on Neuroadaptation and Protein Metabolism, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Loutaev I; Section on Neuroadaptation and Protein Metabolism, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Gu Q; Section on Synapse Development and Plasticity, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Li Z; Section on Synapse Development and Plasticity, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Smith CB; Section on Neuroadaptation and Protein Metabolism, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
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Źródło :
Journal of neurochemistry [J Neurochem] 2019 Dec; Vol. 151 (6), pp. 764-776. Date of Electronic Publication: 2019 Nov 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Amino Acids/*pharmacology
Fragile X Mental Retardation Protein/*metabolism
Hippocampus/*metabolism
Long-Term Synaptic Depression/*physiology
Protein Biosynthesis/*physiology
Signal Transduction/*physiology
Animals ; Fragile X Mental Retardation Protein/genetics ; Hippocampus/drug effects ; Long-Term Synaptic Depression/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Organ Culture Techniques ; Protein Biosynthesis/drug effects ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Corticostriatal synaptic plasticity alterations in the R6/1 transgenic mouse model of Huntington's disease.
Autorzy :
Ghiglieri V; Dipartimento di Filosofia, Scienze sociali, umane e della formazione, Università di Perugia, Perugia, Italy.; Laboratorio di Neurofisiologia, IRCCS Fondazione Santa Lucia, Rome, Italy.
Campanelli F; Laboratorio di Neurofisiologia, IRCCS Fondazione Santa Lucia, Rome, Italy.
Marino G; Laboratorio di Neurofisiologia, IRCCS Fondazione Santa Lucia, Rome, Italy.
Natale G; Laboratorio di Neurofisiologia, IRCCS Fondazione Santa Lucia, Rome, Italy.
Picconi B; Università Telematica San Raffaele, Rome, Italy.; Laboratorio di Neurofisiologia Sperimentale, IRCCS San Raffaele Pisana, Rome, Italy.
Calabresi P; Laboratorio di Neurofisiologia, IRCCS Fondazione Santa Lucia, Rome, Italy.; Clinica Neurologica, Dipartimento di Medicina, Università di Perugia, Perugia, Italy.
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Źródło :
Journal of neuroscience research [J Neurosci Res] 2019 Dec; Vol. 97 (12), pp. 1655-1664. Date of Electronic Publication: 2019 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Long-Term Synaptic Depression*
Cerebral Cortex/*physiology
Corpus Striatum/*physiology
Huntington Disease/*physiopathology
Action Potentials ; Animals ; Disease Models, Animal ; Excitatory Postsynaptic Potentials ; Male ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Sam68 Enables Metabotropic Glutamate Receptor-Dependent LTD in Distal Dendritic Regions of CA1 Hippocampal Neurons.
Autorzy :
Klein ME; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.
Younts TJ; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.
Cobo CF; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.
Buxbaum AR; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA; Center for Neural Circuits and Behavior, Department of Neuroscience and Section for Neurobiology, Division of Biology, University of California at San Diego, San Diego, CA 92093, USA.
Aow J; Center for Neural Circuits and Behavior, Department of Neuroscience and Section for Neurobiology, Division of Biology, University of California at San Diego, San Diego, CA 92093, USA.
Erdjument-Bromage H; Department of Cell Biology and Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Richard S; Segal Cancer Center, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montréal, QC H3T 1E2, Canada.
Malinow R; Center for Neural Circuits and Behavior, Department of Neuroscience and Section for Neurobiology, Division of Biology, University of California at San Diego, San Diego, CA 92093, USA.
Neubert TA; Department of Cell Biology and Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Singer RH; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA; Janelia Research Campus of the Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Castillo PE; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.
Jordan BA; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA; Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2019 Nov 12; Vol. 29 (7), pp. 1789-1799.e6.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Long-Term Synaptic Depression*
Protein Biosynthesis*
Adaptor Proteins, Signal Transducing/*metabolism
CA1 Region, Hippocampal/*metabolism
Dendrites/*metabolism
Pyramidal Cells/*metabolism
RNA-Binding Proteins/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Animals ; CA1 Region, Hippocampal/cytology ; Female ; Mice ; Mice, Knockout ; Pyramidal Cells/cytology ; RNA-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Reversing Cocaine-Induced Plasticity with Zeta Inhibitory Peptide.
Autorzy :
Deutschmann AU; Department of Psychology, and.
Lenz JD; Department of Psychology, and.
McGrath AG; Department of Psychology, and.
Briand LA; Department of Psychology, and .; Neuroscience Program, Temple University, Philadelphia, Pennsylvania 19122.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2019 Sep 25; Vol. 39 (39), pp. 7801-7809. Date of Electronic Publication: 2019 Aug 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell-Penetrating Peptides/*pharmacology
Cocaine/*pharmacology
Drug-Seeking Behavior/*physiology
Lipopeptides/*pharmacology
Long-Term Synaptic Depression/*drug effects
Nucleus Accumbens/*drug effects
Protein Kinase Inhibitors/*pharmacology
Animals ; Cocaine-Related Disorders/physiopathology ; Extinction, Psychological/drug effects ; Long-Term Synaptic Depression/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Nucleus Accumbens/physiology ; Peptides/pharmacology ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Perineuronal Nets Restrict the Induction of Long-Term Depression in the Mouse Hippocampal CA1 Region.
Autorzy :
Khoo GH; Department of Pharmacology, College of Medicine, National Cheng Kung University, No. 1, University Rd., Tainan City, 70101, Taiwan.
Lin YT; Department of Pharmacology, College of Medicine, National Cheng Kung University, No. 1, University Rd., Tainan City, 70101, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
Tsai TC; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
Hsu KS; Department of Pharmacology, College of Medicine, National Cheng Kung University, No. 1, University Rd., Tainan City, 70101, Taiwan. .; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan. .
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Źródło :
Molecular neurobiology [Mol Neurobiol] 2019 Sep; Vol. 56 (9), pp. 6436-6450. Date of Electronic Publication: 2019 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
CA1 Region, Hippocampal/*physiology
Long-Term Synaptic Depression/*physiology
Neurons/*physiology
Animals ; Bumetanide/pharmacology ; CA1 Region, Hippocampal/drug effects ; Electric Stimulation ; Long-Term Synaptic Depression/drug effects ; Male ; Mice, Inbred C57BL ; Neurons/drug effects ; Parvalbumins/metabolism ; Pyramidal Cells/drug effects ; Pyramidal Cells/metabolism ; Receptors, GABA-A/metabolism ; Synapses/drug effects ; Synapses/metabolism
Czasopismo naukowe
Tytuł :
Chemical LTD, but not LTP, induces transient accumulation of gelsolin in dendritic spines.
Autorzy :
Hlushchenko I; Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Tukholmankatu 8, FI-00290 Helsinki, Finland.
Hotulainen P; Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Tukholmankatu 8, FI-00290 Helsinki, Finland.
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Źródło :
Biological chemistry [Biol Chem] 2019 Aug 27; Vol. 400 (9), pp. 1129-1139.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Long-Term Potentiation*
Long-Term Synaptic Depression*
Dendritic Spines/*metabolism
Gelsolin/*metabolism
Animals ; Cells, Cultured ; Rats ; Synapses/metabolism
Czasopismo naukowe
Tytuł :
Endocannabinoid long-term depression revealed at medial perforant path excitatory synapses in the dentate gyrus.
Autorzy :
Peñasco S; Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, E-48940, Leioa, Spain; Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country UPV/EHU, E-48940, Leioa, Spain.
Rico-Barrio I; Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, E-48940, Leioa, Spain; Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country UPV/EHU, E-48940, Leioa, Spain.
Puente N; Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, E-48940, Leioa, Spain; Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country UPV/EHU, E-48940, Leioa, Spain.
Gómez-Urquijo SM; Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, E-48940, Leioa, Spain; Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country UPV/EHU, E-48940, Leioa, Spain.
Fontaine CJ; Division of Medical Sciences, University of Victoria, Victoria, British Columbia, V8P 5C2, Canada.
Egaña-Huguet J; Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, E-48940, Leioa, Spain; Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country UPV/EHU, E-48940, Leioa, Spain.
Achicallende S; Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, E-48940, Leioa, Spain; Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country UPV/EHU, E-48940, Leioa, Spain.
Ramos A; Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, E-48940, Leioa, Spain; Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country UPV/EHU, E-48940, Leioa, Spain.
Reguero L; Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, E-48940, Leioa, Spain; Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country UPV/EHU, E-48940, Leioa, Spain.
Elezgarai I; Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, E-48940, Leioa, Spain; Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country UPV/EHU, E-48940, Leioa, Spain.
Nahirney PC; Division of Medical Sciences, University of Victoria, Victoria, British Columbia, V8P 5C2, Canada.
Christie BR; Division of Medical Sciences, University of Victoria, Victoria, British Columbia, V8P 5C2, Canada.
Grandes P; Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, E-48940, Leioa, Spain; Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country UPV/EHU, E-48940, Leioa, Spain; Division of Medical Sciences, University of Victoria, Victoria, British Columbia, V8P 5C2, Canada. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2019 Jul 15; Vol. 153, pp. 32-40. Date of Electronic Publication: 2019 Apr 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dentate Gyrus/*physiology
Endocannabinoids/*pharmacology
Long-Term Synaptic Depression/*physiology
Perforant Pathway/*physiology
Receptor, Cannabinoid, CB1/*physiology
Synapses/*physiology
Animals ; Dentate Gyrus/drug effects ; Long-Term Synaptic Depression/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Organ Culture Techniques ; Perforant Pathway/drug effects ; Receptor, Cannabinoid, CB1/agonists ; Synapses/drug effects
Czasopismo naukowe
Tytuł :
Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.
Autorzy :
Wagner W; Department of Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany. Electronic address: .
Lippmann K; Carl Ludwig Institute for Physiology, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany.
Heisler FF; Department of Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Gromova KV; Department of Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Lombino FL; Department of Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Roesler MK; Department of Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Pechmann Y; Department of Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Hornig S; Department of Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Schweizer M; Electron Microscopy Unit, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Polo S; Fondazione Istituto FIRC di Oncologia Molecolare (IFOM), 20139 Milan, Italy; Dipartimento di Oncologia ed Emato-oncologia, Università degli Studi di Milano, 20122 Milan, Italy.
Schwarz JR; Department of Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Eilers J; Carl Ludwig Institute for Physiology, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany.
Kneussel M; Department of Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2019 Jul 02; Vol. 28 (1), pp. 11-20.e9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Long-Term Synaptic Depression*/drug effects
Cerebellum/*metabolism
Myosin Heavy Chains/*metabolism
Neurons/*metabolism
Receptors, AMPA/*metabolism
Adaptor Protein Complex alpha Subunits/metabolism ; Animals ; Cells, Cultured ; Cerebellum/cytology ; Cerebellum/physiology ; Clathrin/metabolism ; Dendritic Spines/drug effects ; Dendritic Spines/metabolism ; Endocytosis/genetics ; Endocytosis/physiology ; Hippocampus/cytology ; Hippocampus/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Myosin Heavy Chains/antagonists & inhibitors ; Myosin Heavy Chains/genetics ; Purkinje Cells/metabolism ; Receptors, AMPA/agonists ; Receptors, AMPA/chemistry ; Synaptic Transmission/drug effects ; Synaptic Transmission/genetics ; Synaptic Transmission/physiology
Czasopismo naukowe
Tytuł :
Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo.
Autorzy :
Ondrejcak T; Department of Pharmacology & Therapeutics, Institute of Neuroscience, Trinity College, Dublin 2, Ireland. Electronic address: .
Hu NW; Department of Pharmacology & Therapeutics, Institute of Neuroscience, Trinity College, Dublin 2, Ireland; Department of Physiology and Neurobiology, Zhengzhou University School of Medicine, Zhengzhou 450001, China.
Qi Y; Department of Pharmacology & Therapeutics, Institute of Neuroscience, Trinity College, Dublin 2, Ireland.
Klyubin I; Department of Pharmacology & Therapeutics, Institute of Neuroscience, Trinity College, Dublin 2, Ireland.
Corbett GT; Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Fraser G; Neuroscience, IMED Biotech Unit, AstraZeneca, Cambridge CB21 6GH, UK.
Perkinton MS; Neuroscience, IMED Biotech Unit, AstraZeneca, Cambridge CB21 6GH, UK.
Walsh DM; Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Billinton A; Neuroscience, IMED Biotech Unit, AstraZeneca, Cambridge CB21 6GH, UK.
Rowan MJ; Department of Pharmacology & Therapeutics, Institute of Neuroscience, Trinity College, Dublin 2, Ireland. Electronic address: .
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Źródło :
Neurobiology of disease [Neurobiol Dis] 2019 Jul; Vol. 127, pp. 582-590. Date of Electronic Publication: 2019 Mar 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Peptides/*pharmacology
Hippocampus/*drug effects
Long-Term Synaptic Depression/*drug effects
Protein Aggregates/*physiology
tau Proteins/*metabolism
Animals ; Hippocampus/metabolism ; Long-Term Synaptic Depression/physiology ; Male ; Pyridines/pharmacology ; Rats ; Receptor, Metabotropic Glutamate 5/agonists ; Synapses/drug effects ; Synapses/physiology ; Thiazoles/pharmacology
Czasopismo naukowe
Tytuł :
PRRT1 regulates basal and plasticity-induced AMPA receptor trafficking.
Autorzy :
Troyano-Rodriguez E; Department of Cell Biology and Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Mann S; Department of Cell Biology and Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Ullah R; Department of Cell Biology and Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Ahmad M; Department of Cell Biology and Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address: .
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Źródło :
Molecular and cellular neurosciences [Mol Cell Neurosci] 2019 Jul; Vol. 98, pp. 155-163. Date of Electronic Publication: 2019 Jun 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Long-Term Synaptic Depression*
Membrane Proteins/*metabolism
Nerve Tissue Proteins/*metabolism
Receptors, AMPA/*metabolism
Animals ; CA1 Region, Hippocampal/cytology ; CA1 Region, Hippocampal/metabolism ; HEK293 Cells ; Humans ; Membrane Proteins/genetics ; Mice ; Mice, Inbred C57BL ; N-Methylaspartate/metabolism ; Nerve Tissue Proteins/genetics ; Protein Transport ; Pyramidal Cells/metabolism
Czasopismo naukowe

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