- Tytuł:
- Discovery of novel biaryl benzoxazepinones as dual-mode receptor-interacting protein kinase-1 (RIPK1) inhibitors.
- Autorzy:
- Źródło:
- Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Feb 15; Vol. 100, pp. 117611. Date of Electronic Publication: 2024 Feb 01.
- Typ publikacji:
- Journal Article
- MeSH Terms:
-
Inflammation*/metabolism
Receptor-Interacting Protein Serine-Threonine Kinases*/antagonists & inhibitors
Receptor-Interacting Protein Serine-Threonine Kinases*/metabolismSystemic Inflammatory Response Syndrome */chemically inducedSystemic Inflammatory Response Syndrome */drug therapySystemic Inflammatory Response Syndrome */metabolism
Animals ; Humans ; Mice ; Apoptosis ; HT29 Cells ; Necrosis ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Protein Kinases/metabolism ; Azepines/chemistry ; Azepines/pharmacology
Czasopismo naukowe