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Tytuł:
T Cell Receptor Chain Centricity: The Phenomenon and Potential Applications in Cancer Immunotherapy.
Autorzy:
Kalinina AA; N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, 115478 Moscow, Russia.
Khromykh LM; N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, 115478 Moscow, Russia.
Kazansky DB; N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, 115478 Moscow, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 16; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 16.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Receptors, Antigen, T-Cell*/genetics
Neoplasms*/therapy
Humans ; Retrospective Studies ; T-Lymphocyte Subsets ; Immunotherapy ; Immunotherapy, Adoptive
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse.
Autorzy:
Stinchcombe JC; Cambridge Institute for Medical Research, Keith Peters Building, Cambridge CB2 0XY, UK.
Asano Y; Cambridge Institute for Medical Research, Keith Peters Building, Cambridge CB2 0XY, UK.
Kaufman CJG; Cambridge Institute for Medical Research, Keith Peters Building, Cambridge CB2 0XY, UK.
Böhlig K; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
Peddie CJ; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Collinson LM; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Nadler A; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
Griffiths GM; Cambridge Institute for Medical Research, Keith Peters Building, Cambridge CB2 0XY, UK.
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Źródło:
Science (New York, N.Y.) [Science] 2023 May 26; Vol. 380 (6647), pp. 818-823. Date of Electronic Publication: 2023 May 25.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, Antigen, T-Cell*/metabolism
T-Lymphocytes, Cytotoxic*/immunology
Exocytosis*/immunology
Immunological Synapses*/immunology
Immunological Synapses*/ultrastructure
Diglycerides*/metabolism
Cell Division ; Cell Membrane/metabolism ; Cell-Derived Microparticles/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cell activation-based screening of natively paired human T cell receptor repertoires.
Autorzy:
Fahad AS; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, 66044, USA.
Chung CY; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, 66044, USA.
López Acevedo SN; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, 66044, USA.
Boyle N; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, 66044, USA.
Madan B; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, 66044, USA.
Gutiérrez-González MF; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, 66044, USA.
Matus-Nicodemos R; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Laflin AD; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, 66044, USA.
Ladi RR; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, 66044, USA.
Zhou J; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, 66044, USA.
Wolfe J; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, 66044, USA.
Llewellyn-Lacey S; Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, CF14 4XN, UK.
Koup RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Douek DC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Balfour HH Jr; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.; Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Price DA; Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, CF14 4XN, UK.; Systems Immunity Research Institute, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, CF14 4XN, UK.
DeKosky BJ; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, 66044, USA. .; Department of Chemical Engineering, The University of Kansas, Lawrence, KS, 66044, USA. .; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. .; The Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 May 17; Vol. 13 (1), pp. 8011. Date of Electronic Publication: 2023 May 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
MeSH Terms:
T-Lymphocytes*
Receptors, Antigen, T-Cell*
Humans ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Cloning, Molecular ; Antigens ; Peptides/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Deep autoregressive generative models capture the intrinsics embedded in T-cell receptor repertoires.
Autorzy:
Jiang Y; Department of Computer science, City University of Hong Kong, Kowloon Tong, Hong Kong.
Li SC; Department of Computer science, City University of Hong Kong, Kowloon Tong, Hong Kong.
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Źródło:
Briefings in bioinformatics [Brief Bioinform] 2023 Mar 19; Vol. 24 (2).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, Antigen, T-Cell*/genetics
Models, Statistical*
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Attention-aware contrastive learning for predicting T cell receptor-antigen binding specificity.
Autorzy:
Fang Y; School of Computer Science and Technology, Nanjing Tech University, 211816, Nanjing, China.
Liu X; School of Computer Science and Technology, Nanjing Tech University, 211816, Nanjing, China.
Liu H; School of Computer Science and Technology, Nanjing Tech University, 211816, Nanjing, China.
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Źródło:
Briefings in bioinformatics [Brief Bioinform] 2022 Nov 19; Vol. 23 (6).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, Antigen, T-Cell*
T-Lymphocytes*
Protein Binding ; Histocompatibility Antigens Class I/metabolism ; HLA Antigens ; Attention ; Amino Acids/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
T-cell receptor variable region usage in Chagas disease: A systematic review of experimental and human studies.
Autorzy:
de Souza-Silva TG; Institute of Biological Sciences, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Gollob KJ; Hospital Israelita Albert Einstein, São Paulo, Brazil.; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Belo Horizonte, Minas Gerais, Brazil.
Dutra WO; Institute of Biological Sciences, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Belo Horizonte, Minas Gerais, Brazil.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2022 Sep 15; Vol. 16 (9), pp. e0010546. Date of Electronic Publication: 2022 Sep 15 (Print Publication: 2022).
Typ publikacji:
Journal Article; Review; Systematic Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Chagas Disease*
Receptors, Antigen, T-Cell*/genetics
Animals ; Cytokines ; Humans ; Ligands ; Mice ; Peptides
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The splenic T cell receptor repertoire during an immune response against a complex antigen: Expanding private clones accumulate in the high and low copy number region.
Autorzy:
Meinhardt M; Institute of Anatomy, University of Lübeck, Lübeck, Germany.
Tune C; Institute of Anatomy, University of Lübeck, Lübeck, Germany.
Schierloh LK; Institute of Anatomy, University of Lübeck, Lübeck, Germany.
Schampel A; Institute of Anatomy, University of Lübeck, Lübeck, Germany.
Pagel R; Institute of Anatomy, University of Lübeck, Lübeck, Germany.
Westermann J; Institute of Anatomy, University of Lübeck, Lübeck, Germany.
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Źródło:
PloS one [PLoS One] 2022 Aug 24; Vol. 17 (8), pp. e0273264. Date of Electronic Publication: 2022 Aug 24 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Copy Number Variations*
Receptors, Antigen, T-Cell*/genetics
Animals ; Clone Cells ; Immunity ; Mice ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Sheep ; T-Lymphocytes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TCRpower: quantifying the detection power of T-cell receptor sequencing with a novel computational pipeline calibrated by spike-in sequences.
Autorzy:
Dahal-Koirala S; K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, 0372, Norway.; Department of Immunology, University of Oslo and Oslo University Hospital-Rikshospitalet, Oslo, 0372, Norway.
Balaban G; Biomedical Informatics, Department of Informatics, University of Oslo, 0373, Oslo, Norway.; Department of Computational Physiology, Simula Research Laboratory, 1364, Fornebu, Norway.; PharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, 0373, Oslo, Norway.
Neumann RS; K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, 0372, Norway.
Scheffer L; Biomedical Informatics, Department of Informatics, University of Oslo, 0373, Oslo, Norway.
Lundin KEA; K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, 0372, Norway.; Department of Gastroenterology, Oslo University Hospital-Rikshospitalet, 0372, Oslo, Norway.
Greiff V; Department of Immunology, University of Oslo and Oslo University Hospital-Rikshospitalet, Oslo, 0372, Norway.
Sollid LM; K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, 0372, Norway.; Department of Immunology, University of Oslo and Oslo University Hospital-Rikshospitalet, Oslo, 0372, Norway.
Qiao SW; K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, 0372, Norway.; Department of Immunology, University of Oslo and Oslo University Hospital-Rikshospitalet, Oslo, 0372, Norway.
Sandve GK; Biomedical Informatics, Department of Informatics, University of Oslo, 0373, Oslo, Norway.; PharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, 0373, Oslo, Norway.
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Źródło:
Briefings in bioinformatics [Brief Bioinform] 2022 Mar 10; Vol. 23 (2).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, Antigen, T-Cell*/genetics
Humans ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; T-Lymphocytes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Recycling and Reshaping-E3 Ligases and DUBs in the Initiation of T Cell Receptor-Mediated Signaling and Response.
Autorzy:
Cammann C; Friedrich Loeffler-Institute of Medical Microbiology-Virology, University Medicine Greifswald, 17475 Greifswald, Germany.
Israel N; Friedrich Loeffler-Institute of Medical Microbiology-Virology, University Medicine Greifswald, 17475 Greifswald, Germany.
Slevogt H; Host Septomics Group, Centre for Innovation Competence (ZIK) Septomics, University Hospital Jena, 07745 Jena, Germany.; Department of Pulmonary Medicine, Hannover Medical School, 30625 Hannover, Germany.
Seifert U; Friedrich Loeffler-Institute of Medical Microbiology-Virology, University Medicine Greifswald, 17475 Greifswald, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Mar 22; Vol. 23 (7). Date of Electronic Publication: 2022 Mar 22.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Deubiquitinating Enzymes*/metabolism
Receptors, Antigen, T-Cell*/metabolism
Signal Transduction*
Ubiquitin-Protein Ligases*/metabolism
Ubiquitin/metabolism ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Tuning T cell receptor sensitivity through catch bond engineering.
Autorzy:
Zhao X; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kolawole EM; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Chan W; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Feng Y; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Yang X; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Gee MH; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jude KM; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sibener LV; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Fordyce PM; Department of Genetics, Stanford University, Stanford, CA 94305, USA.; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.; ChEM-H Institute, Stanford University, Stanford, CA 94305, USA.; Chan Zuckerberg BioHub, San Francisco, CA 94158, USA.
Germain RN; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Evavold BD; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Garcia KC; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Apr 08; Vol. 376 (6589), pp. eabl5282. Date of Electronic Publication: 2022 Apr 08.
Typ publikacji:
Journal Article
MeSH Terms:
Immunotherapy, Adoptive*
Receptors, Antigen, T-Cell*
T-Lymphocytes*/metabolism
Antigens, Neoplasm ; Cross Reactions ; Major Histocompatibility Complex ; Myocardium/immunology ; Peptides
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The interplay between membrane topology and mechanical forces in regulating T cell receptor activity.
Autorzy:
Al-Aghbar MA; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Department of Translational Medicine, Sidra Medicine, Doha, Qatar.
Jainarayanan AK; Interdisciplinary Bioscience Doctoral Training Program and Exeter College, University of Oxford, Oxford, UK.; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Dustin ML; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. .
Roffler SR; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. .; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. .
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Źródło:
Communications biology [Commun Biol] 2022 Jan 11; Vol. 5 (1), pp. 40. Date of Electronic Publication: 2022 Jan 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Cell Membrane*/chemistry
Cell Membrane*/metabolism
Mechanoreceptors*/chemistry
Mechanoreceptors*/metabolism
Receptors, Antigen, T-Cell*/chemistry
Receptors, Antigen, T-Cell*/metabolism
Biomechanical Phenomena/*physiology
Signal Transduction/*physiology
Antigen-Presenting Cells/chemistry ; Cells, Cultured ; Histocompatibility Antigens/chemistry ; Histocompatibility Antigens/metabolism ; Humans ; Lymphocyte Activation/physiology ; T-Lymphocytes/chemistry ; T-Lymphocytes/cytology ; T-Lymphocytes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
T-Cell Receptor Repertoire Analysis with Computational Tools-An Immunologist's Perspective.
Autorzy:
Arunkumar M; Department of Infection Immunology, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knoell-Institute, 07745 Jena, Germany.; Department of Biological Sciences, Friedrich Schiller University, 07743 Jena, Germany.; Bioinformatics, Ludwig Maximilians University Munich, 80539 Munich, Germany.
Zielinski CE; Department of Infection Immunology, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knoell-Institute, 07745 Jena, Germany.; Department of Biological Sciences, Friedrich Schiller University, 07743 Jena, Germany.
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Źródło:
Cells [Cells] 2021 Dec 18; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Allergy and Immunology*
Computational Biology*
Receptors, Antigen, T-Cell/*metabolism
Data Analysis ; Humans ; Software ; T-Lymphocytes/cytology ; T-Lymphocytes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
DLpTCR: an ensemble deep learning framework for predicting immunogenic peptide recognized by T cell receptor.
Autorzy:
Xu Z; Center for Bioinformatics, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Luo M; Center for Bioinformatics, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Lin W; Center for Bioinformatics, Computer Department, Jingdezhen Ceramic Institute, Jingdezhen 333403, China.
Xue G; Center for Bioinformatics, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Wang P; Center for Bioinformatics, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Jin X; Center for Bioinformatics, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Xu C; Center for Bioinformatics, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Zhou W; Center for Bioinformatics, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Cai Y; Center for Bioinformatics, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Yang W; Center for Bioinformatics, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Nie H; Center for Bioinformatics, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.
Jiang Q; Center for Bioinformatics, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China.; Key Laboratory of Biological Data (Harbin Institute of Technology), Ministry of Education, China.
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Źródło:
Briefings in bioinformatics [Brief Bioinform] 2021 Nov 05; Vol. 22 (6).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19 Drug Treatment*
Epitopes/*immunology
Peptides/*immunology
Receptors, Antigen, T-Cell/*immunology
SARS-CoV-2/*immunology
Amino Acid Sequence/genetics ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/virology ; Computer Simulation ; Deep Learning ; Epitopes/genetics ; Humans ; Peptides/genetics ; Peptides/therapeutic use ; Protein Binding/genetics ; Receptors, Antigen, T-Cell/genetics ; SARS-CoV-2/genetics ; SARS-CoV-2/pathogenicity ; Software
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Common T-Cell-Receptor Motifs and Features in Patients with Cytomegalovirus (CMV)-Seronegative End-Stage Renal Disease Receiving a Peptide Vaccination against CMV.
Autorzy:
Bunse L; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Department of Neurology, MCTN, Medical Faculty Mannheim, Heidelberg University, 69117 Heidelberg, Germany.
Sommerer C; Division of Nephrology, University Hospital Heidelberg, Renal Clinic Heidelberg, 69120 Heidelberg, Germany.
Tan CL; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, 69117 Heidelberg, Germany.
Korell F; Department of Internal Medicine V, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Schmitt A; Department of Internal Medicine V, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Hückelhoven-Krauss A; Department of Internal Medicine V, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Neuber B; Department of Internal Medicine V, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Mertens T; Institute of Virology, University of Ulm, 89081 Ulm, Germany.
Platten M; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Department of Neurology, MCTN, Medical Faculty Mannheim, Heidelberg University, 69117 Heidelberg, Germany.; Immune Monitoring Unit, DKFZ and National Center for Tumor Diseases, 69120 Heidelberg, Germany.
Green EW; DKTK CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Zeier M; Division of Nephrology, University Hospital Heidelberg, Renal Clinic Heidelberg, 69120 Heidelberg, Germany.
Schmitt M; Department of Internal Medicine V, University Hospital Heidelberg, 69120 Heidelberg, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 18; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 18.
Typ publikacji:
Journal Article
MeSH Terms:
Cytomegalovirus Infections/*prevention & control
Kidney Failure, Chronic/*therapy
Receptors, Antigen, T-Cell/*genetics
Viral Matrix Proteins/*administration & dosage
CD8-Positive T-Lymphocytes/immunology ; Clinical Trials, Phase I as Topic ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Vaccines/administration & dosage ; Cytomegalovirus Vaccines/immunology ; Humans ; Kidney Failure, Chronic/immunology ; Kidney Transplantation ; Sequence Analysis, RNA ; Single Molecule Imaging ; Viral Matrix Proteins/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Circulating tumor DNA by high-throughput sequencing of T cell receptor monitored treatment response and predicted treatment failure in T cell lymphomas.
Autorzy:
Zhang W; Department of Hematology, Peking Union Medical College Hospital, Beijing, China.
Wang W; Department of Hematology, Peking Union Medical College Hospital, Beijing, China.
Han X; Department of Hematology, Peking Union Medical College Hospital, Beijing, China.
Gan Y; Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Qian L; Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Zhang Y; Department of Hematology, Peking Union Medical College Hospital, Beijing, China.
Zhang C; Geneplus-Beijing, Beijing, China.
Wang Y; Geneplus-Beijing, Beijing, China.
Guan Y; Geneplus-Beijing, Beijing, China.
Yang L; Geneplus-Beijing, Beijing, China.
Zhou D; Department of Hematology, Peking Union Medical College Hospital, Beijing, China.
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Źródło:
International journal of laboratory hematology [Int J Lab Hematol] 2021 Oct; Vol. 43 (5), pp. 1041-1049. Date of Electronic Publication: 2021 Mar 18.
Typ publikacji:
Clinical Trial; Journal Article
MeSH Terms:
Circulating Tumor DNA/*genetics
Lymphoma, T-Cell/*genetics
Receptors, Antigen, T-Cell/*genetics
Adult ; Aged ; Biomarkers, Tumor/genetics ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Lymphoma, T-Cell/diagnosis ; Lymphoma, T-Cell/therapy ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Impact of HLA type, age and chronic viral infection on peripheral T-cell receptor sharing between unrelated individuals.
Autorzy:
Johnson SA; Adaptive Biotechnologies, Seattle, Washington, United States of America.
Seale SL; Adaptive Biotechnologies, Seattle, Washington, United States of America.
Gittelman RM; Adaptive Biotechnologies, Seattle, Washington, United States of America.
Rytlewski JA; Adaptive Biotechnologies, Seattle, Washington, United States of America.
Robins HS; Adaptive Biotechnologies, Seattle, Washington, United States of America.
Fields PA; Adaptive Biotechnologies, Seattle, Washington, United States of America.
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Źródło:
PloS one [PLoS One] 2021 Aug 30; Vol. 16 (8), pp. e0249484. Date of Electronic Publication: 2021 Aug 30 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Histocompatibility Testing*/methods
HLA Antigens/*immunology
Receptors, Antigen, T-Cell/*immunology
Virus Diseases/*immunology
Adult ; Age Factors ; Chronic Disease ; Cytomegalovirus Infections/immunology ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction.
Autorzy:
Estrada A 3rd; Department of Biological Sciences, The University of Texas At El Paso, El Paso, TX, 79968, USA.; Border Biomedical Research Center, The University of Texas At El Paso, El Paso, TX, 79968, USA.
Rodriguez AC; Department of Biological Sciences, The University of Texas At El Paso, El Paso, TX, 79968, USA.; Border Biomedical Research Center, The University of Texas At El Paso, El Paso, TX, 79968, USA.
Rodriguez G; Department of Biological Sciences, The University of Texas At El Paso, El Paso, TX, 79968, USA.; Border Biomedical Research Center, The University of Texas At El Paso, El Paso, TX, 79968, USA.
Grant AH; Department of Biological Sciences, The University of Texas At El Paso, El Paso, TX, 79968, USA.; Border Biomedical Research Center, The University of Texas At El Paso, El Paso, TX, 79968, USA.
Ayala-Marin YM; Department of Biological Sciences, The University of Texas At El Paso, El Paso, TX, 79968, USA.; Border Biomedical Research Center, The University of Texas At El Paso, El Paso, TX, 79968, USA.
Arrieta AJ; Department of Biological Sciences, The University of Texas At El Paso, El Paso, TX, 79968, USA.
Kirken RA; Department of Biological Sciences, The University of Texas At El Paso, El Paso, TX, 79968, USA. .; Border Biomedical Research Center, The University of Texas At El Paso, El Paso, TX, 79968, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Aug 20; Vol. 11 (1), pp. 16951. Date of Electronic Publication: 2021 Aug 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Signal Transduction*
Adaptor Proteins, Signal Transducing/*metabolism
Cytokines/*metabolism
Interleukin Receptor Common gamma Subunit/*metabolism
Interleukin-2/*metabolism
Phosphoserine/*metabolism
Receptors, Antigen, T-Cell/*metabolism
Adaptor Proteins, Signal Transducing/chemistry ; Amino Acid Sequence ; Antibodies/metabolism ; Cell Line ; Humans ; MAP Kinase Signaling System ; Peptides/chemistry ; Peptides/metabolism ; Phosphorylation ; Phosphotyrosine/metabolism ; Protein Processing, Post-Translational ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Associations between T cell infiltration, T cell receptor clonality, histology and recurrence in renal cell carcinoma.
Autorzy:
Gadot M; Oncology Institute, Sheba Medical Center, Tel-Hashomer, Israel.
Gal M; Faculty of Life Science, Bar Ilan University, Ramat-Gan, Israel.
Dobosz P; Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Warszawa, Poland.
Dotan Z; Department of Urology, Sheba Medical Center, Tel-Hashomer, Israel.; Faculty of Medicine, Tel-Aviv university, Tel-Aviv, Israel.
Ramon J; Department of Urology, Sheba Medical Center, Tel-Hashomer, Israel.; Faculty of Medicine, Tel-Aviv university, Tel-Aviv, Israel.
Berger R; Oncology Institute, Sheba Medical Center, Tel-Hashomer, Israel.; Faculty of Medicine, Tel-Aviv university, Tel-Aviv, Israel.
Avni D; Faculty of Medicine, Tel-Aviv university, Tel-Aviv, Israel.; Laboratory of Molecular Cell Biology, Sheba Medical Center, Tel-Hashomer, Israel.
Fridman E; Faculty of Medicine, Tel-Aviv university, Tel-Aviv, Israel.; Pathology Institute, Sheba Medical Center, Tel-Hashomer, Israel.
Leibowitz R; Faculty of Medicine, Tel-Aviv university, Tel-Aviv, Israel.; Oncology Institute, Shamir Medical Center, Zerifin, Israel.
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2021 Aug; Vol. 205 (2), pp. 160-168. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Renal Cell/*immunology
Kidney Neoplasms/*immunology
Neoplasm Recurrence, Local/*immunology
Receptors, Antigen, T-Cell/*immunology
T-Lymphocytes/*immunology
Female ; Humans ; Male ; Middle Aged ; Retrospective Studies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+ T Cells.
Autorzy:
Shin SH; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul 07804, Korea.
Cho KA; Department of Microbiology, College of Medicine, Ewha Womans University, Seoul 07804, Korea.
Yoon HS; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul 07804, Korea.
Kim SY; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul 07804, Korea.
Kim HY; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul 07804, Korea.
Pewzner-Jung Y; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
Jung SA; Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul 07804, Korea.
Park WJ; Department of Biochemistry, College of Medicine, Gachon University, Incheon 21999, Korea.
Futerman AH; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
Park JW; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul 07804, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 08; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 08.
Typ publikacji:
Journal Article
MeSH Terms:
Asthma/*immunology
Receptors, Antigen, T-Cell/*immunology
Signal Transduction/*immunology
Sphingosine N-Acyltransferase/*deficiency
Th17 Cells/*immunology
Th2 Cells/*immunology
Animals ; Asthma/chemically induced ; Asthma/genetics ; Asthma/pathology ; Mice ; Mice, Knockout ; Ovalbumin/toxicity ; Receptors, Antigen, T-Cell/genetics ; Signal Transduction/genetics ; Sphingosine N-Acyltransferase/immunology ; Th17 Cells/pathology ; Th2 Cells/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Affinity Maturation of a T-Cell Receptor-Like Antibody Specific for a Cytomegalovirus pp65-Derived Peptide Presented by HLA-A*02:01.
Autorzy:
Lee SY; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea.
Ko DH; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea.
Son MJ; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea.
Kim JA; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea.
Jung K; Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon 16499, Korea.
Kim YS; Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea.; Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon 16499, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 26; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 26.
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies/*immunology
Cytomegalovirus/*immunology
Cytomegalovirus Infections/*immunology
HLA-A Antigens/*immunology
Receptors, Antigen, T-Cell/*immunology
Viral Matrix Proteins/*immunology
Antibody Affinity ; Cell Line ; Humans ; Peptides/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 1502

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