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Tytuł :
Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells.
Autorzy :
Harsha Krovi S; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Evergrande Center for Immunologic diseases at Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Zhang J; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Stanford Health Care, Department of Pathology, Stanford University, Stanford, CA, USA.
Michaels-Foster MJ; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Brunetti T; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Loh L; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Scott-Browne J; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA.
Gapin L; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. .; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 07; Vol. 11 (1), pp. 6238. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Differentiation/*immunology
Immunity, Innate/*immunology
Natural Killer T-Cells/*immunology
Single-Cell Analysis/*methods
T-Lymphocytes/*immunology
Thymus Gland/*immunology
Animals ; Cell Differentiation/genetics ; Cells, Cultured ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/immunology ; DNA-Binding Proteins/metabolism ; Gene Expression Profiling/methods ; Immunity, Innate/genetics ; Mice, Inbred C57BL ; Mice, Knockout ; Mucosal-Associated Invariant T Cells/cytology ; Mucosal-Associated Invariant T Cells/immunology ; Mucosal-Associated Invariant T Cells/metabolism ; Natural Killer T-Cells/cytology ; Natural Killer T-Cells/metabolism ; Sequence Analysis, RNA/methods ; T-Lymphocytes/cytology ; T-Lymphocytes/metabolism ; Thymocytes/cytology ; Thymocytes/immunology ; Thymocytes/metabolism ; Thymus Gland/cytology ; Thymus Gland/metabolism
Czasopismo naukowe
Tytuł :
T cell receptor diversity, specificity and promiscuity of functionally heterogeneous human MR1-restricted T cells.
Autorzy :
Lepore M; Immunocore Ltd Milton Park, Abingdon, United Kingdom. Electronic address: .
Lewinsohn DA; Department of Pediatrics, Oregon Health & Science University, Portland, OR, United States.
Lewinsohn DM; Department of Medicine, Oregon Health & Science University, Portland VA Medical Center, Portland, OR, United States. Electronic address: .
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Źródło :
Molecular immunology [Mol Immunol] 2021 Feb; Vol. 130, pp. 64-68. Date of Electronic Publication: 2020 Dec 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Histocompatibility Antigens Class I/*metabolism
Minor Histocompatibility Antigens/*metabolism
Mucosal-Associated Invariant T Cells/*metabolism
Receptors, Antigen, T-Cell/*immunology
T-Cell Antigen Receptor Specificity/*physiology
T-Lymphocyte Subsets/*immunology
Histocompatibility Antigens Class I/immunology ; Humans ; Immunity, Mucosal/immunology ; Minor Histocompatibility Antigens/immunology ; Mucosal-Associated Invariant T Cells/immunology ; Receptors, Antigen, T-Cell/physiology ; Receptors, Antigen, T-Cell, alpha-beta
Czasopismo naukowe
Tytuł :
Biological functions of MAIT cells in tissues.
Autorzy :
Klenerman P; Peter Medawar Building for Pathogen Research, South Parks Road, Oxford, OX1 3SY, UK; National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), John Radcliffe Hospital, Oxford, OX3 9DU, UK; Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, OX3 9DU, UK. Electronic address: .
Hinks TSC; National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), John Radcliffe Hospital, Oxford, OX3 9DU, UK; Respiratory Medicine Unit, Nuffield Department of Medicine Experimental Medicine, University of Oxford, OX3 9DU, Oxfordshire, UK.
Ussher JE; Department of Microbiology and Immunology, University of Otago, Dunedin, 9054, Otago, New Zealand; Southern Community Laboratories, Dunedin, 9016, Otago, New Zealand.
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Źródło :
Molecular immunology [Mol Immunol] 2021 Feb; Vol. 130, pp. 154-158. Date of Electronic Publication: 2020 Dec 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Mucosal-Associated Invariant T Cells/*immunology
Animals ; Bacterial Infections/immunology ; Homeostasis ; Humans ; Mucosal-Associated Invariant T Cells/cytology ; Mucosal-Associated Invariant T Cells/metabolism ; Neoplasms/immunology ; Receptors, Antigen, T-Cell ; Virus Diseases/immunology
Czasopismo naukowe
Tytuł :
Using agonists for iNKT cells in cancer therapy.
Autorzy :
Painter GF; Ferrier Research Institute, Victoria University of Wellington, Lower Hutt, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand. Electronic address: .
Burn OK; Malaghan Institute of Medical Research, Wellington, New Zealand.
Hermans IF; Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand; Malaghan Institute of Medical Research, Wellington, New Zealand. Electronic address: .
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Źródło :
Molecular immunology [Mol Immunol] 2021 Feb; Vol. 130, pp. 1-6. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Galactosylceramides/*therapeutic use
Immunotherapy/*methods
Lymphocyte Activation/*drug effects
Natural Killer T-Cells/*drug effects
Neoplasms/*therapy
Adjuvants, Immunologic/therapeutic use ; Animals ; Antigen-Presenting Cells/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cancer Vaccines/therapeutic use ; Galactosylceramides/pharmacology ; Humans ; Lymphocyte Activation/physiology ; Natural Killer T-Cells/physiology ; Natural Killer T-Cells/transplantation ; Neoplasms/immunology
Czasopismo naukowe
Tytuł :
Immune-Related Adverse Events Associated With Immune Checkpoint Inhibitor Therapy.
Autorzy :
Ho AK; From the Department of Clinical Oncology, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Ho AM; Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada.
Cooksley T; Department of Acute Medicine and Critical Care, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Nguyen G; Department of Radiology, Queen's University, Kingston, Ontario, Canada.
Erb J; Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada.
Mizubuti GB; Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada.
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Źródło :
Anesthesia and analgesia [Anesth Analg] 2021 Feb 01; Vol. 132 (2), pp. 374-383.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Autoimmune Diseases/*chemically induced
Autoimmunity/*drug effects
Immune Checkpoint Inhibitors/*adverse effects
Immunity, Innate/*drug effects
Natural Killer T-Cells/*drug effects
Self Tolerance/*drug effects
Animals ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Humans ; Immunosuppressive Agents/therapeutic use ; Natural Killer T-Cells/immunology ; Natural Killer T-Cells/metabolism ; Prognosis ; Risk Assessment ; Risk Factors
Czasopismo naukowe
Tytuł :
Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure.
Autorzy :
Murray MP; La Jolla Institute for Immunology, La Jolla, CA, USA.
Engel I; La Jolla Institute for Immunology, La Jolla, CA, USA.
Seumois G; La Jolla Institute for Immunology, La Jolla, CA, USA.
Herrera-De la Mata S; La Jolla Institute for Immunology, La Jolla, CA, USA.
Rosales SL; La Jolla Institute for Immunology, La Jolla, CA, USA.
Sethi A; La Jolla Institute for Immunology, La Jolla, CA, USA.
Logandha Ramamoorthy Premlal A; La Jolla Institute for Immunology, La Jolla, CA, USA.
Seo GY; La Jolla Institute for Immunology, La Jolla, CA, USA.
Greenbaum J; La Jolla Institute for Immunology, La Jolla, CA, USA.
Vijayanand P; La Jolla Institute for Immunology, La Jolla, CA, USA.; University of Southampton, Faculty of Medicine, Southampton, UK.; Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Scott-Browne JP; La Jolla Institute for Immunology, La Jolla, CA, USA. .; Department of Biomedical Research, National Jewish Health, Denver, CO, USA. .
Kronenberg M; La Jolla Institute for Immunology, La Jolla, CA, USA. .; Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 04; Vol. 12 (1), pp. 1446. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Lung/*cytology
Natural Killer T-Cells/*cytology
T Follicular Helper Cells/*cytology
T-Lymphocyte Subsets/*cytology
Thymus Gland/*cytology
Animals ; Cell Differentiation/immunology ; Chromatin/genetics ; Female ; Lung/immunology ; Lymphocyte Activation/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Natural Killer T-Cells/immunology ; T Follicular Helper Cells/immunology ; T-Lymphocyte Subsets/immunology ; Thymus Gland/immunology ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
Purification and Expansion of Mouse Invariant Natural Killer T Cells for in vitro and in vivo Studies.
Autorzy :
Delfanti G; Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute; .
Perini A; Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University.
Zappa E; Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University.
Fedeli M; Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University; .
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2021 Feb 15 (168). Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Cell Separation/*methods
Natural Killer T-Cells/*immunology
Animals ; CD4 Antigens/metabolism ; Cell Proliferation ; Lymphocyte Activation/immunology ; Mice ; Natural Killer T-Cells/cytology ; Spleen/cytology
Czasopismo naukowe
Tytuł :
Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients.
Autorzy :
Deschler S; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Kager J; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Erber J; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Fricke L; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Koyumdzhieva P; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Georgieva A; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Lahmer T; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Wiessner JR; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Voit F; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Schneider J; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Horstmann J; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Iakoubov R; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Treiber M; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Winter C; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, 81675 Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Ruland J; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, 81675 Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Busch DH; Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, 81675 Munich, Germany.
Knolle PA; Institute of Molecular Immunology and Experimental Oncology, University Hospital Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
Protzer U; Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, 81675 Munich, Germany.; German Center for Infection Research (DZIF), 38124 Braunschweig, Partner Site Munich, Germany.
Spinner CD; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.; German Center for Infection Research (DZIF), 38124 Braunschweig, Partner Site Munich, Germany.
Schmid RM; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Quante M; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.; Freiburg University Medical Center, Department of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Böttcher K; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
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Źródło :
Viruses [Viruses] 2021 Feb 03; Vol. 13 (2). Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphocyte Activation*
COVID-19/*immunology
Mucosal-Associated Invariant T Cells/*immunology
Adaptive Immunity ; COVID-19/physiopathology ; Cytokines/metabolism ; Female ; Granzymes/metabolism ; HLA-DR Antigens ; Humans ; Interleukin-17/metabolism ; Killer Cells, Natural/immunology ; Male ; Mucosal-Associated Invariant T Cells/metabolism ; Severity of Illness Index ; T-Lymphocyte Subsets/immunology ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Immune responses and pathogenesis in persistently PCR-positive patients with SARS-CoV-2 infection.
Autorzy :
Yu HB; Department Three of Liver Disease Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Wang WJ; Beijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Tang S; Department Three of Liver Disease Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Chen DX; Beijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Xu B; Department Two of Liver Disease Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
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Źródło :
Journal of medical virology [J Med Virol] 2021 Feb; Vol. 93 (2), pp. 760-765. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Variation, Individual*
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*pathology
Natural Killer T-Cells/*immunology
SARS-CoV-2/*pathogenicity
Adult ; Aged ; Antigens, CD/genetics ; Antigens, CD/immunology ; CD4-Positive T-Lymphocytes/virology ; CD8-Positive T-Lymphocytes/virology ; COVID-19/immunology ; COVID-19/virology ; COVID-19 Testing ; Female ; Gene Expression ; HLA-DR Antigens/genetics ; HLA-DR Antigens/immunology ; Humans ; Immunity, Innate ; Immunophenotyping ; Lymphocyte Count ; Male ; Middle Aged ; Natural Killer T-Cells/virology ; Phenotype ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2/genetics ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients.
Autorzy :
Jouan Y; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.; Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.; Service de chirurgie cardiaque et de réanimation chirurgicale cardio-vasculaire, Centre Hospitalier Régional Universitaire, Tours, France.
Guillon A; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.; Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.
Gonzalez L; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.
Perez Y; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.; Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.
Boisseau C; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.
Ehrmann S; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.; Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.
Ferreira M; Université de Tours, Faculté de Médecine de Tours, Tours, France.; Service de pneumologie, Centre Hospitalier Régional Universitaire, Tours, France.
Daix T; Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France.; Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges, France.; Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges, France.
Jeannet R; Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France.; Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges, France.; Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges, France.
François B; Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France.; Institut national de la santé et de la recherche médicale CIC1435, Dupuytren Teaching Hospital, Limoges, France.; Institut national de la santé et de la recherche médicale UMR 1092, University of Limoges, Limoges, France.
Dequin PF; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.; Service de Médecine Intensive et Réanimation, Centre Hospitalier Régional Universitaire, Tours, France.
Si-Tahar M; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.
Baranek T; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.
Paget C; Institut national de la santé et de la recherche médicale, Centre d'Etude des Pathologies Respiratoires, UMR 1100, Tours, France.; Université de Tours, Faculté de Médecine de Tours, Tours, France.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2020 Dec 07; Vol. 217 (12).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Phenotype*
Betacoronavirus/*genetics
Coronavirus Infections/*immunology
Mucosal-Associated Invariant T Cells/*metabolism
Natural Killer T-Cells/*metabolism
Pneumonia, Viral/*immunology
Receptors, Antigen, T-Cell, gamma-delta/*metabolism
Respiratory Distress Syndrome/*immunology
Aged ; Antigens, CD/blood ; Antigens, Differentiation, T-Lymphocyte/blood ; COVID-19 ; Cells, Cultured ; Coronavirus Infections/virology ; Cytokines/metabolism ; Female ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Lectins, C-Type/blood ; Male ; Middle Aged ; Mucosal-Associated Invariant T Cells/immunology ; Natural Killer T-Cells/immunology ; Pandemics ; Pneumonia, Viral/virology ; Prognosis ; Prospective Studies ; Respiratory Distress Syndrome/virology ; SARS-CoV-2 ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Major reduction of NKT cells in patients with severe COVID-19 pneumonia.
Autorzy :
Zingaropoli MA; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy. Electronic address: .
Perri V; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
Pasculli P; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
Cogliati Dezza F; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
Nijhawan P; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
Savelloni G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
La Torre G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
D'Agostino C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
Mengoni F; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
Lichtner M; Infectious Diseases Unit, SM Goretti Hospital, Polo Pontino, Sapienza University of Rome, Latina, Italy.
Ciardi MR; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
Mastroianni CM; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
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Źródło :
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2021 Jan; Vol. 222, pp. 108630. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article
MeSH Terms :
SARS-CoV-2*
COVID-19/*pathology
Natural Killer T-Cells/*physiology
Aged ; Aged, 80 and over ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Female ; Gene Expression Regulation ; Humans ; Male ; Middle Aged ; Natural Killer T-Cells/classification ; Natural Killer T-Cells/metabolism
Czasopismo naukowe
Tytuł :
Mucosal-associated invariant T cells and oral microbiome in persistent apical periodontitis.
Autorzy :
Davanian H; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Gaiser RA; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Silfverberg M; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Hugerth LW; Department of Microbiology, Tumor and Cell Biology and Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.; Clinical Genomics Facility, Science for Life Laboratory, Solna, Sweden.
Sobkowiak MJ; Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
Lu L; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Healy K; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Sandberg JK; Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
Näsman P; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Karlsson J; Clinic of Endodontics and Periodontology, Eastman Institute Stockholm, Stockholm, Sweden.
Jansson L; Clinic of Endodontics and Periodontology, Eastman Institute Stockholm, Stockholm, Sweden.
Engstrand L; Department of Microbiology, Tumor and Cell Biology and Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.; Clinical Genomics Facility, Science for Life Laboratory, Solna, Sweden.
Sällberg Chen M; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden. .
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Źródło :
International journal of oral science [Int J Oral Sci] 2019 May 09; Vol. 11 (2), pp. 16. Date of Electronic Publication: 2019 May 09.
Typ publikacji :
Journal Article
MeSH Terms :
Microbiota*
Mucosal-Associated Invariant T Cells*
Immunity, Mucosal/*immunology
Periapical Periodontitis/*surgery
Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Natural Killer T-Cells/immunology ; Periapical Periodontitis/microbiology
Czasopismo naukowe
Tytuł :
Contribution of NKT cells to the immune response and pathogenesis triggered by respiratory viruses.
Autorzy :
Rey-Jurado E; Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile , Santiago, Chile.
Bohmwald K; Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile , Santiago, Chile.
Gálvez NMS; Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile , Santiago, Chile.
Becerra D; Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile , Santiago, Chile.
Porcelli SA; Department of Microbiology and Immunology, and Department of Medicine, Albert Einstein College of Medicine , Bronx, NY, USA.
Carreño LJ; Millennium Institute on Immunology and Immunotherapy, Programa de Inmunología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile , Santiago, Chile.
Kalergis AM; Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile , Santiago, Chile.; Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile , Santiago, Chile.
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Źródło :
Virulence [Virulence] 2020 Dec; Vol. 11 (1), pp. 580-593.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Natural Killer T-Cells/*immunology
Paramyxoviridae Infections/*immunology
Respiratory Syncytial Virus Infections/*immunology
Respiratory Tract Infections/*virology
Virus Replication/*immunology
Animals ; Antigens, CD1d/genetics ; Antigens, CD1d/immunology ; Humans ; Lung/immunology ; Lung/virology ; Macrophages, Alveolar/immunology ; Macrophages, Alveolar/virology ; Male ; Metapneumovirus/pathogenicity ; Metapneumovirus/physiology ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Natural Killer T-Cells/pathology ; Respiratory Syncytial Virus, Human/pathogenicity ; Respiratory Syncytial Virus, Human/physiology
Czasopismo naukowe
Tytuł :
Rab6 regulates recycling and retrograde trafficking of MR1 molecules.
Autorzy :
Huber ME; Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 97239, USA.
Kurapova R; Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.
Heisler CM; Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.
Karamooz E; Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.; VA Portland Health Care System, 3710 SW US Veterans Hospital Rd, R&D11, Portland, OR, 97239, USA.
Tafesse FG; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 97239, USA.
Harriff MJ; Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA. .; VA Portland Health Care System, 3710 SW US Veterans Hospital Rd, R&D11, Portland, OR, 97239, USA. .; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 97239, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 27; Vol. 10 (1), pp. 20778. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Histocompatibility Antigens Class I/*metabolism
Minor Histocompatibility Antigens/*metabolism
Mucosal-Associated Invariant T Cells/*immunology
rab GTP-Binding Proteins/*metabolism
Adult ; Antigen Presentation ; Cell Line ; Cell Membrane/immunology ; Cell Membrane/metabolism ; Endosomes/immunology ; Endosomes/metabolism ; Gene Silencing ; Histocompatibility Antigens Class I/genetics ; Humans ; Immunity, Innate ; In Vitro Techniques ; Kinetics ; Ligands ; Minor Histocompatibility Antigens/genetics ; Mucosal-Associated Invariant T Cells/metabolism ; Mucosal-Associated Invariant T Cells/microbiology ; Mycobacterium tuberculosis/immunology ; Mycobacterium tuberculosis/pathogenicity ; Promoter Regions, Genetic ; Protein Transport ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/immunology ; trans-Golgi Network/immunology ; trans-Golgi Network/metabolism
Czasopismo naukowe
Tytuł :
Translating viral vaccines into immunity.
Autorzy :
Juno JA; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity at the University of Melbourne, Melbourne, VIC, Australia. .
O'Connor SL; Department of Pathology and Laboratory Medicine, The University of Wisconsin-Madison, Madison, WI, USA. .; Wisconsin National Primate Research Center, Madison, WI, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jan 29; Vol. 371 (6528), pp. 460-461.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Mucosal-Associated Invariant T Cells*
Viral Vaccines*
Adenoviridae ; Immunity, Humoral ; Immunogenicity, Vaccine
Czasopismo naukowe
Tytuł :
Boosting MAIT cells as immunotherapy: context is everything.
Autorzy :
Hinks TSC; Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine Experimental Medicine, University of Oxford, Oxford, OX3 9DU, UK. .
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Źródło :
Mucosal immunology [Mucosal Immunol] 2021 Jan; Vol. 14 (1), pp. 1-3. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Mucosal-Associated Invariant T Cells*
Tuberculosis*
Humans ; Immunotherapy
Czasopismo naukowe
Tytuł :
High-Dimensional Flow Cytometry Analysis of Regulatory Receptors on Human T Cells, NK Cells, and NKT Cells.
Autorzy :
Nakagawa R; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Brayer J; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Restrepo N; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Mulé JJ; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.; Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA.
Mailloux AW; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2194, pp. 255-290.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Flow Cytometry/*methods
Immune Checkpoint Proteins/*metabolism
Immunophenotyping/*methods
Killer Cells, Natural/*immunology
Natural Killer T-Cells/*immunology
Antibodies ; Humans ; Killer Cells, Natural/cytology ; Natural Killer T-Cells/cytology ; Staining and Labeling/methods
Czasopismo naukowe
Tytuł :
Successful direct-acting antiviral therapy improves circulating mucosal-associated invariant T cells in patients with chronic HCV infection.
Autorzy :
Khlaiphuengsin A; Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Chuaypen N; Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Sodsai P; Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Reantragoon R; Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Han WM; HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Center, Bangkok, Thailand.
Avihingsanon A; HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Center, Bangkok, Thailand.
Tangkijvanich P; Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
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Źródło :
PloS one [PLoS One] 2020 Dec 31; Vol. 15 (12), pp. e0244112. Date of Electronic Publication: 2020 Dec 31 (Print Publication: 2020).
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*administration & dosage
Benzofurans/*administration & dosage
Hepacivirus/*immunology
Hepatitis C, Chronic/*drug therapy
Hepatitis C, Chronic/*immunology
Imidazoles/*administration & dosage
Mucosal-Associated Invariant T Cells/*immunology
Quinoxalines/*administration & dosage
Adult ; Drug Combinations ; Female ; Hepacivirus/metabolism ; Hepatitis C, Chronic/blood ; Humans ; Male ; Middle Aged ; Mucosal-Associated Invariant T Cells/metabolism
Czasopismo naukowe
Tytuł :
Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells.
Autorzy :
Priya R; Department of Microbiology and Immunology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, United States. Electronic address: .
Brutkiewicz RR; Department of Microbiology and Immunology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, United States. Electronic address: .
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Źródło :
Journal of neuroimmunology [J Neuroimmunol] 2020 Dec 15; Vol. 349, pp. 577428. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*metabolism
Brain/*metabolism
Histocompatibility Antigens Class I/*biosynthesis
Immunity, Innate/*physiology
Microglia/*metabolism
Minor Histocompatibility Antigens/*biosynthesis
Mucosal-Associated Invariant T Cells/*metabolism
Animals ; Astrocytes/immunology ; Brain/immunology ; Cell Line ; Female ; Histocompatibility Antigens Class I/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microglia/immunology ; Minor Histocompatibility Antigens/immunology ; Mucosal-Associated Invariant T Cells/immunology
Czasopismo naukowe

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