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Wyszukujesz frazę ""T-cell activation"" wg kryterium: Temat


Tytuł :
The significance of immune-regulatory molecule B7-H4 in small cell lung cancer.
Autorzy :
Zhang X; Department of Respiratory Medicine, Affiliated Hospital of Jiangnan University, Wuxi, China.
Song S; Department of Pathology Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Zhang F; Department of Respiratory Medicine, Affiliated Hospital of Jiangnan University, Wuxi, China.
Cai L; Department of Respiratory Medicine, Affiliated Hospital of Jiangnan University, Wuxi, China.
Xie W; Department of Respiratory Medicine, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, China. .
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Źródło :
Annals of palliative medicine [Ann Palliat Med] 2020 Jul; Vol. 9 (4), pp. 1953-1957. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers*/analysis
Lung Neoplasms*
Small Cell Lung Carcinoma*
V-Set Domain-Containing T-Cell Activation Inhibitor 1*/analysis
Humans ; Lymphatic Metastasis ; Prognosis
Czasopismo naukowe
Tytuł :
B7H4 expression in tumor cells impairs CD8 T cell responses and tumor immunity.
Autorzy :
Zhou L; Institute of Immunotherapy, Fujian Medical University, No. 1 Xuefu North Road, Shangjie Town, Minhou County, Fuzhou, 350122, China.
Ruan M; Institute of Immunotherapy, Fujian Medical University, No. 1 Xuefu North Road, Shangjie Town, Minhou County, Fuzhou, 350122, China.
Liu Y; Institute of Immunotherapy, Fujian Medical University, No. 1 Xuefu North Road, Shangjie Town, Minhou County, Fuzhou, 350122, China.
Zhu Y; Institute of Immunotherapy, Fujian Medical University, No. 1 Xuefu North Road, Shangjie Town, Minhou County, Fuzhou, 350122, China.
Fu D; Institute of Immunotherapy, Fujian Medical University, No. 1 Xuefu North Road, Shangjie Town, Minhou County, Fuzhou, 350122, China.
Wu K; The First Affiliated Hospital of Fujian Medical University, No. 20 Chating Middle Road, Fuzhou, 350005, China.
Zhang Q; The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China. .; Institute of Immunotherapy, Fujian Medical University, No. 1 Xuefu North Road, Shangjie Town, Minhou County, Fuzhou, 350122, China. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Feb; Vol. 69 (2), pp. 163-174. Date of Electronic Publication: 2019 Dec 17.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression*
CD8-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*metabolism
Immunity/*genetics
Neoplasms/*etiology
Neoplasms/*metabolism
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*genetics
Animals ; Biomarkers ; Cell Line, Tumor ; Cytotoxicity, Immunologic ; Disease Models, Animal ; Female ; Humans ; Immunohistochemistry ; Immunophenotyping ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Mice ; Neoplasms/pathology ; Neoplasms/therapy ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; V-Set Domain-Containing T-Cell Activation Inhibitor 1/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
The B7x Immune Checkpoint Pathway: From Discovery to Clinical Trial.
Autorzy :
John P; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Wei Y; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Liu W; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY 10461, USA.
Du M; Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai 200011, China.
Guan F; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Zang X; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA; Department of Medicine, Albert Einstein College of Medicine, New York, NY 10461, USA; Department of Urology, Albert Einstein College of Medicine, New York, NY 10461, USA. Electronic address: .
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Źródło :
Trends in pharmacological sciences [Trends Pharmacol Sci] 2019 Nov; Vol. 40 (11), pp. 883-896. Date of Electronic Publication: 2019 Oct 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Arthritis, Rheumatoid/*drug therapy
Arthritis, Rheumatoid/*immunology
Neoplasms/*drug therapy
Neoplasms/*immunology
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*antagonists & inhibitors
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*immunology
Animals ; Antineoplastic Agents, Immunological/administration & dosage ; Clinical Trials, Phase I as Topic ; Humans ; Immune Tolerance ; Models, Molecular ; Molecular Targeted Therapy ; Randomized Controlled Trials as Topic ; Signal Transduction ; Translational Medical Research ; V-Set Domain-Containing T-Cell Activation Inhibitor 1/chemistry
Czasopismo naukowe
Tytuł :
Downregulation of B7-H4 suppresses tumor progression of hepatocellular carcinoma.
Autorzy :
Dong L; Department of Imaging, Binzhou Medical University, Binzhou, Shandong, 264003, P.R. China.; Department of Radiology, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, P.R. China.
Xie L; Department of Imaging, Binzhou Medical University, Binzhou, Shandong, 264003, P.R. China.
Li M; Medicine & Pharmacy Research Center, Binzhou Medical University, Yantai, Shandong, 264003, P.R. China.
Dai H; Department of Imaging, Binzhou Medical University, Binzhou, Shandong, 264003, P.R. China.
Wang X; Department of Oral Pathology, Binzhou Medical University, Yantai, Shandong, 264003, P.R. China.
Wang P; Department of Imaging, Binzhou Medical University, Binzhou, Shandong, 264003, P.R. China.
Zhang Q; Medicine & Pharmacy Research Center, Binzhou Medical University, Yantai, Shandong, 264003, P.R. China.
Liu W; Department of Imaging, Binzhou Medical University, Binzhou, Shandong, 264003, P.R. China.
Hu X; Department of Immunology, Binzhou Medical University, Yantai, Shandong, 264003, P.R. China. .
Zhao M; Department of Imaging, Binzhou Medical University, Binzhou, Shandong, 264003, P.R. China. .
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Źródło :
Scientific reports [Sci Rep] 2019 Oct 16; Vol. 9 (1), pp. 14854. Date of Electronic Publication: 2019 Oct 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Carcinoma, Hepatocellular/*genetics
Liver Neoplasms/*genetics
RNA, Small Interfering/*genetics
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*genetics
Animals ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Apoptosis/genetics ; Cadherins/genetics ; Cadherins/metabolism ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase 7/genetics ; Caspase 7/metabolism ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Disease Progression ; Female ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Mice ; Mice, Nude ; RNA, Small Interfering/metabolism ; Signal Transduction ; Survivin/genetics ; Survivin/metabolism ; Tumor Burden ; V-Set Domain-Containing T-Cell Activation Inhibitor 1/antagonists & inhibitors ; V-Set Domain-Containing T-Cell Activation Inhibitor 1/metabolism ; Vimentin/genetics ; Vimentin/metabolism ; Xenograft Model Antitumor Assays ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Expression of co-inhibitory molecules B7-H4 and B7-H1 in Epstein-Barr virus positive diffuse large B-cell lymphoma and their roles in tumor invasion.
Autorzy :
Jiang Y; Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, 200080, China.
Lin J; Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, 200080, China.
Zhang J; Department of Integrated Therapy, Fudan University Shanghai Cancer Center, 270 Dongan Road, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, 138 Yi xue yuan Road, Shanghai, 200032, China.
Lu S; Department of Hematology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 160 Pujian Road, Shanghai 200127, China.
Wang C; Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, 200080, China. Electronic address: .
Tong Y; Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, 200080, China. Electronic address: .
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Źródło :
Pathology, research and practice [Pathol Res Pract] 2019 Dec; Vol. 215 (12), pp. 152684. Date of Electronic Publication: 2019 Oct 07.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Movement*
B7-H1 Antigen/*metabolism
Epstein-Barr Virus Infections/*virology
Herpesvirus 4, Human/*pathogenicity
Lymphoma, Large B-Cell, Diffuse/*metabolism
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*metabolism
Adult ; Aged ; Aged, 80 and over ; B7-H1 Antigen/immunology ; Cell Line, Tumor ; Epstein-Barr Virus Infections/immunology ; Female ; Herpesvirus 4, Human/immunology ; Host-Pathogen Interactions ; Humans ; Lymphoma, Large B-Cell, Diffuse/immunology ; Lymphoma, Large B-Cell, Diffuse/pathology ; Lymphoma, Large B-Cell, Diffuse/virology ; Male ; Middle Aged ; Neoplasm Invasiveness ; Signal Transduction ; V-Set Domain-Containing T-Cell Activation Inhibitor 1/immunology
Czasopismo naukowe
Tytuł :
[Expression of costimulatory molecules B7H3 and B7H4 in T lymphoblastic lymphoma/leukemia and clinical significance].
Autorzy :
Zhang GZ; Department of Pathology, Basic Medical College of Shanxi Medical University, Taiyuan 030013, China.
Li J; Department of Pathology, Shanxi Cancer Hospital, Taiyuan 030013, China.
Bai WQ; Department of Pathology, Shanxi Cancer Hospital, Taiyuan 030013, China.
Bu P; Department of Pathology, Shanxi Cancer Hospital, Taiyuan 030013, China.
Wang HW; Department of Pathology, Shanxi Cancer Hospital, Taiyuan 030013, China.
Xi YF; Department of Pathology, Shanxi Cancer Hospital, Taiyuan 030013, China.
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Źródło :
Zhonghua bing li xue za zhi = Chinese journal of pathology [Zhonghua Bing Li Xue Za Zhi] 2019 May 08; Vol. 48 (5), pp. 352-357.
Typ publikacji :
Journal Article
MeSH Terms :
B7 Antigens*/metabolism
Lymphoma, T-Cell*/metabolism
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/metabolism
V-Set Domain-Containing T-Cell Activation Inhibitor 1*/metabolism
Female ; Humans ; Immunohistochemistry ; Male ; Prognosis ; RNA, Messenger
Czasopismo naukowe
Tytuł :
A T-cell-engaging B7-H4/CD3-bispecific Fab-scFv Antibody Targets Human Breast Cancer.
Autorzy :
Iizuka A; Immunotherapy Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.
Nonomura C; Immunotherapy Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.
Ashizawa T; Immunotherapy Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.
Kondou R; Immunotherapy Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.
Ohshima K; Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.
Sugino T; Division of Pathology, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Mitsuya K; Division of Neurosurgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Hayashi N; Division of Neurosurgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Nakasu Y; Division of Neurosurgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Maruyama K; Experimental Animal Facility, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.
Yamaguchi K; Office of the President, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Akiyama Y; Immunotherapy Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan. .; Division of Neurosurgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2019 May 01; Vol. 25 (9), pp. 2925-2934. Date of Electronic Publication: 2019 Feb 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Bispecific/*pharmacology
Breast Neoplasms/*therapy
CD3 Complex/*immunology
Immunoglobulin Fab Fragments/*immunology
Single-Chain Antibodies/*immunology
T-Lymphocytes/*immunology
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*immunology
Animals ; Antibodies, Bispecific/pharmacokinetics ; Antigens, Neoplasm/immunology ; Apoptosis ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/immunology ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/pathology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Prognosis ; Tissue Distribution ; Tumor Cells, Cultured ; V-Set Domain-Containing T-Cell Activation Inhibitor 1/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Insulin-like growth factor-1 receptor induces immunosuppression in lung cancer by upregulating B7-H4 expression through the MEK/ERK signaling pathway.
Autorzy :
Zhao Z; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Zhang N; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Li A; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Zhou B; Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Jiangsu Key Laboratory of Clinical Immunology, Soochow University, Suzhou, Jiangsu, China; Jiangsu Key Laboratory of Gastrointestinal Tumor Immunology, Soochow University, Suzhou, Jiangsu, China.
Chen Y; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Chen S; Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Huang M; Department of Bioinformatics, School of Biology & Basic Medical Sciences, Soochow University, Suzhou, China.
Wu F; Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: .
Zhang L; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China; Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Jiangsu Key Laboratory of Clinical Immunology, Soochow University, Suzhou, Jiangsu, China; Jiangsu Key Laboratory of Gastrointestinal Tumor Immunology, Soochow University, Suzhou, Jiangsu, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Aug 10; Vol. 485, pp. 14-26. Date of Electronic Publication: 2020 May 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immune Tolerance*
Lung Neoplasms/*immunology
MAP Kinase Signaling System/*physiology
Receptor, IGF Type 1/*physiology
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*genetics
Adult ; Aged ; Aged, 80 and over ; Animals ; CD8-Positive T-Lymphocytes/immunology ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/drug therapy ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged
Czasopismo naukowe
Tytuł :
[Knockdown of B7-H4/VTCN1 promotes apoptosis and autophagy of Huh7 cells by inhibiting phosphorylation of JNK].
Autorzy :
Hao T; Department of Hepatobiliary Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
Lei D; Department of Hepatobiliary Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
Hu G; Department of Hepatobiliary Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
Liao R; Department of Hepatobiliary Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
Luo F; Department of Hepatobiliary Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China. *Corresponding author, E-mail: .
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Źródło :
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology [Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi] 2020 Jul; Vol. 36 (7), pp. 603-608.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*/genetics
Carcinoma, Hepatocellular*/genetics
Liver Neoplasms*/genetics
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*genetics
Apoptosis/genetics ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Phosphorylation
Czasopismo naukowe
Tytuł :
Expression and clinical significance of PD-L1, B7-H3, B7-H4 and TILs in human small cell lung Cancer (SCLC).
Autorzy :
Carvajal-Hausdorf D; Department of Pathology, Yale School of Medicine, New Haven, USA.; Anatomia Patologica, Clinica Alemana, Facultad de Medicina Universidad del Desarrollo, Santiago, Chile.
Altan M; Medical Oncology, Yale School of Medicine and Yale Cancer Center, 333 Cedar St. FMP117, New Haven, CT, 06520-8023, USA.; Thoracic Oncology, MD Anderson Cancer Center, Camden, USA.
Velcheti V; Thoracic Oncology, New York University, New York, USA.
Gettinger SN; Medical Oncology, Yale School of Medicine and Yale Cancer Center, 333 Cedar St. FMP117, New Haven, CT, 06520-8023, USA.
Herbst RS; Medical Oncology, Yale School of Medicine and Yale Cancer Center, 333 Cedar St. FMP117, New Haven, CT, 06520-8023, USA.
Rimm DL; Department of Pathology, Yale School of Medicine, New Haven, USA.; Medical Oncology, Yale School of Medicine and Yale Cancer Center, 333 Cedar St. FMP117, New Haven, CT, 06520-8023, USA.
Schalper KA; Department of Pathology, Yale School of Medicine, New Haven, USA. .; Anatomia Patologica, Clinica Alemana, Facultad de Medicina Universidad del Desarrollo, Santiago, Chile. .; Medical Oncology, Yale School of Medicine and Yale Cancer Center, 333 Cedar St. FMP117, New Haven, CT, 06520-8023, USA. .
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Źródło :
Journal for immunotherapy of cancer [J Immunother Cancer] 2019 Mar 08; Vol. 7 (1), pp. 65. Date of Electronic Publication: 2019 Mar 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
B7 Antigens/*metabolism
B7-H1 Antigen/*metabolism
Lung Neoplasms/*etiology
Lung Neoplasms/*metabolism
Lymphocytes, Tumor-Infiltrating/*immunology
Lymphocytes, Tumor-Infiltrating/*metabolism
Small Cell Lung Carcinoma/*etiology
Small Cell Lung Carcinoma/*metabolism
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*metabolism
Aged ; Aged, 80 and over ; B7 Antigens/genetics ; B7-H1 Antigen/genetics ; Biomarkers, Tumor ; Female ; Fluorescent Antibody Technique ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Lymphocytes, Tumor-Infiltrating/pathology ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Small Cell Lung Carcinoma/mortality ; Small Cell Lung Carcinoma/pathology ; V-Set Domain-Containing T-Cell Activation Inhibitor 1/genetics
Czasopismo naukowe
Tytuł :
Combined detection of CA19-9 and B7-H4 in the diagnosis and prognosis of pancreatic cancer.
Autorzy :
Xu X; Department of Colorectal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Department of Colorectal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Xiao Y; Department of Clinical Laboratory, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Hong B; Department of Pathology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Hao B; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Qian Y; Department of Clinical Laboratory, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
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Źródło :
Cancer biomarkers : section A of Disease markers [Cancer Biomark] 2019; Vol. 25 (3), pp. 251-257.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, Tumor-Associated, Carbohydrate/*blood
Biomarkers, Tumor/*blood
Pancreatic Neoplasms/*genetics
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*blood
Adult ; Aged ; Aged, 80 and over ; Antigens, Tumor-Associated, Carbohydrate/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Pancreatic Neoplasms/blood ; Pancreatic Neoplasms/pathology ; Prognosis ; V-Set Domain-Containing T-Cell Activation Inhibitor 1/genetics
Czasopismo naukowe
Tytuł :
Molecular subgroups and B7-H4 expression levels predict responses to dendritic cell vaccines in glioblastoma: an exploratory randomized phase II clinical trial.
Autorzy :
Yao Y; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.; Neurosurgical Immunology Laboratory of Huashan Hospital, Fudan University, Shanghai, 200040, China.
Luo F; Biotherapy Research Center of Fudan University and Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Tang C; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.; Neurosurgical Immunology Laboratory of Huashan Hospital, Fudan University, Shanghai, 200040, China.
Chen D; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.; Neurosurgical Immunology Laboratory of Huashan Hospital, Fudan University, Shanghai, 200040, China.
Qin Z; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.; Neurosurgical Immunology Laboratory of Huashan Hospital, Fudan University, Shanghai, 200040, China.
Hua W; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xu M; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zhong P; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yu S; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.; Neurosurgical Immunology Laboratory of Huashan Hospital, Fudan University, Shanghai, 200040, China.
Chen D; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.; Neurosurgical Immunology Laboratory of Huashan Hospital, Fudan University, Shanghai, 200040, China.
Ding X; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.; Neurosurgical Immunology Laboratory of Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zhang Y; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zheng X; Department of Immunology and Biotherapy Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Yang J; Department of Immunology and Biotherapy Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Qian J; Department of Immunology and Biotherapy Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Deng Y; Department of Immunology and Biotherapy Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Hoon DSB; Department of Translational Molecular Medicine, John Wayne Cancer Institute (JWCI), Pacific Neuroscience Institute, Saint John's Health Center, Providence Health Systems, Santa Monica, CA, 90404, USA.
Hu J; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Chu Y; Department of Immunology and Biotherapy Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. .
Zhou L; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. .; Neurosurgical Immunology Laboratory of Huashan Hospital, Fudan University, Shanghai, 200040, China. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2018 Nov; Vol. 67 (11), pp. 1777-1788. Date of Electronic Publication: 2018 Aug 22.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
MeSH Terms :
Mutation*
Biomarkers, Tumor/*genetics
Cancer Vaccines/*therapeutic use
Dendritic Cells/*immunology
Glioblastoma/*immunology
Neoplasm Recurrence, Local/*immunology
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*metabolism
Adolescent ; Adult ; Aged ; Brain Neoplasms/genetics ; Brain Neoplasms/immunology ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Combined Modality Therapy ; Double-Blind Method ; Female ; Follow-Up Studies ; Glioblastoma/genetics ; Glioblastoma/pathology ; Glioblastoma/therapy ; Humans ; Isocitrate Dehydrogenase/genetics ; Male ; Middle Aged ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/therapy ; Prognosis ; Promoter Regions, Genetic ; Survival Rate ; Telomerase/genetics ; V-Set Domain-Containing T-Cell Activation Inhibitor 1/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
B7-H3 and B7-H4 expression in phyllodes tumors of the breast detected by RNA in situ hybridization and immunohistochemistry: Association with clinicopathological features and T-cell infiltration.
Autorzy :
Kim GE; 1 Department of Pathology, Chonnam National University Medical School, Gwangju, South Korea.
Kim NI; 1 Department of Pathology, Chonnam National University Medical School, Gwangju, South Korea.
Park MH; 1 Department of Pathology, Chonnam National University Medical School, Gwangju, South Korea.
Lee JS; 1 Department of Pathology, Chonnam National University Medical School, Gwangju, South Korea.; 3 Department of Pathology, Chonnam National University Hwasun Hospital, Hwasun, South Korea.
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Źródło :
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2018 Nov; Vol. 40 (11), pp. 1010428318815032.
Typ publikacji :
Journal Article
MeSH Terms :
B7 Antigens/*metabolism
Breast Neoplasms/*pathology
Lymphocytes, Tumor-Infiltrating/*immunology
Phyllodes Tumor/*pathology
RNA, Neoplasm/*genetics
T-Lymphocytes/*immunology
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*metabolism
Adult ; B7 Antigens/genetics ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/immunology ; Breast Neoplasms/metabolism ; Case-Control Studies ; Disease Progression ; Female ; Follow-Up Studies ; Gene Expression Regulation, Neoplastic ; Humans ; In Situ Hybridization ; Middle Aged ; Phyllodes Tumor/genetics ; Phyllodes Tumor/immunology ; Phyllodes Tumor/metabolism ; Prognosis ; Tissue Array Analysis ; V-Set Domain-Containing T-Cell Activation Inhibitor 1/genetics
Czasopismo naukowe
Tytuł :
Negative roles of B7-H3 and B7-H4 in the microenvironment of cervical cancer.
Autorzy :
Han S; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, PR China.
Wang Y; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, PR China.
Shi X; Department of Rheumatism and Immunology, General Hospital of Tianjin Medical University, Tianjin 300000, PR China.
Zong L; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, PR China.
Liu L; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, PR China.
Zhang J; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, PR China.
Qian Q; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, PR China.
Jin J; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, PR China.
Ma Y; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, PR China.
Cui B; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, PR China.
Yang X; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, PR China.
Kong B; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, PR China.
Zhang Y; Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, PR China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2018 Oct 01; Vol. 371 (1), pp. 222-230. Date of Electronic Publication: 2018 Aug 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
B7 Antigens/*genetics
Interleukin-10/*genetics
Transforming Growth Factor beta1/*genetics
Tumor Microenvironment/*genetics
Uterine Cervical Neoplasms/*genetics
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*genetics
Adult ; Animals ; Apoptosis/genetics ; B7 Antigens/immunology ; Cell Cycle/genetics ; Cell Line, Tumor ; Disease Progression ; Female ; HeLa Cells ; Heterografts ; Humans ; Interleukin-10/immunology ; Lymphatic Metastasis ; Mice ; Mice, Nude ; Middle Aged ; Monocytes/immunology ; Monocytes/pathology ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/immunology ; Signal Transduction ; Survival Analysis ; Transforming Growth Factor beta1/immunology ; Tumor Microenvironment/immunology ; Uterine Cervical Neoplasms/immunology ; Uterine Cervical Neoplasms/mortality ; Uterine Cervical Neoplasms/pathology ; V-Set Domain-Containing T-Cell Activation Inhibitor 1/immunology
Czasopismo naukowe
Tytuł :
B7-Homolog 4 Promotes Epithelial-Mesenchymal Transition and Invasion of Bladder Cancer Cells via Activation of Nuclear Factor-κB.
Autorzy :
Wu H; Department of Urology, Wujin Hospital, Affiliated to Jiangsu University, Changzhou, P.R. China.
Wang X; Department of Urology, Wujin Hospital, Affiliated to Jiangsu University, Changzhou, P.R. China.
Mo N; Department of Urology, Wujin Hospital, Affiliated to Jiangsu University, Changzhou, P.R. China.
Zhang L; Department of Urology, Wujin Hospital, Affiliated to Jiangsu University, Changzhou, P.R. China.
Yuan X; Department of Urology, Wujin Hospital, Affiliated to Jiangsu University, Changzhou, P.R. China.
Lü Z; Department of Urology, Wujin Hospital, Affiliated to Jiangsu University, Changzhou, P.R. China.
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Źródło :
Oncology research [Oncol Res] 2018 Sep 14; Vol. 26 (8), pp. 1267-1274. Date of Electronic Publication: 2018 Feb 01.
Typ publikacji :
Journal Article
MeSH Terms :
NF-kappa B/*metabolism
Urinary Bladder Neoplasms/*metabolism
Urinary Bladder Neoplasms/*pathology
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*metabolism
Cell Line, Tumor ; Cell Movement/physiology ; Epithelial-Mesenchymal Transition ; Gene Knockdown Techniques ; Humans ; Neoplasm Invasiveness ; Signal Transduction ; Urinary Bladder Neoplasms/genetics ; V-Set Domain-Containing T-Cell Activation Inhibitor 1/biosynthesis ; V-Set Domain-Containing T-Cell Activation Inhibitor 1/genetics
Czasopismo naukowe
Tytuł :
Soluble B7-H4 blood serum levels are elevated in women at high risk for preeclampsia in the first trimester, as well as in patients with confirmed preeclampsia.
Autorzy :
Mach P; Department of Obstetrics and Gynecology, University Hospital of Essen, Essen, Germany.
Nolte-Boenigk L; Department of Obstetrics and Gynecology, University Hospital of Essen, Essen, Germany.
Droste L; Department of Obstetrics and Gynecology, University Hospital of Essen, Essen, Germany.
Fox L; Department of Obstetrics and Gynecology, University Hospital of Essen, Essen, Germany.
Frank M; Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.
Schmidt B; Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.
Herse F; Charité Medical Faculty, Experimental and Clinical Research Center, a joint cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany.
Verlohren S; Department of Obstetrics, Charité University Medicine, Berlin, Germany.
Wicherek L; Department of Gynecology and Oncology and Gynecological Nursing, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Iannaccone A; Department of Obstetrics and Gynecology, University Hospital of Essen, Essen, Germany.
Birdir C; Department of Obstetrics and Gynecology, University Hospital of Essen, Essen, Germany.; Medical Faculty, Department of Obstetrics and Gynecology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Andrikos D; Department of Obstetrics and Gynecology, University Hospital of Essen, Essen, Germany.
Kimmig R; Department of Obstetrics and Gynecology, University Hospital of Essen, Essen, Germany.
Gellhaus A; Department of Obstetrics and Gynecology, University Hospital of Essen, Essen, Germany.
Köninger A; Department of Obstetrics and Gynecology, University Hospital of Essen, Essen, Germany.
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Źródło :
American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2018 Sep; Vol. 80 (3), pp. e12988. Date of Electronic Publication: 2018 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers/*blood
Placenta/*physiology
Pre-Eclampsia/*immunology
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*blood
Adult ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immune Tolerance ; Pre-Eclampsia/diagnosis ; Pregnancy ; Pregnancy Trimester, First ; Prognosis ; Risk ; Up-Regulation ; V-Set Domain-Containing T-Cell Activation Inhibitor 1/genetics
Czasopismo naukowe
Tytuł :
B7S1, a novel candidate for anti-tumor checkpoint blockade immunotherapy.
Autorzy :
Chen X; Institute of Immunology, Third Military Medical University, Chongqing, 400038, China.
Ye L; Institute of Immunology, Third Military Medical University, Chongqing, 400038, China. .
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Źródło :
Science China. Life sciences [Sci China Life Sci] 2018 Sep; Vol. 61 (9), pp. 1132-1134. Date of Electronic Publication: 2018 Jun 21.
Typ publikacji :
Journal Article
MeSH Terms :
Immunotherapy/*methods
Neoplasms/*immunology
Neoplasms/*therapy
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*immunology
CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Humans ; Ligands ; Models, Immunological ; Neoplasms/metabolism ; Programmed Cell Death 1 Receptor/immunology ; Programmed Cell Death 1 Receptor/metabolism ; V-Set Domain-Containing T-Cell Activation Inhibitor 1/metabolism
Czasopismo naukowe
Tytuł :
B7-H4 is a potential prognostic biomarker of prostate cancer.
Autorzy :
Li H; Institute for Regenerative Medicine, Yanbian University College of Medicine, Yanji 133002, PR China; Department of Pathology, Yanbian University College of Medicine, Yanji 133002, PR China.
Piao L; Institute for Regenerative Medicine, Yanbian University College of Medicine, Yanji 133002, PR China; Department of Pathology, Yanbian University College of Medicine, Yanji 133002, PR China.
Liu S; Department of Oncology, Affiliated Hospital of Yanbian University, Yanji 133002, PR China.
Cui Y; Department of Oncology, Affiliated Hospital of Yanbian University, Yanji 133002, PR China.
Xuan Y; Institute for Regenerative Medicine, Yanbian University College of Medicine, Yanji 133002, PR China; Department of Pathology, Yanbian University College of Medicine, Yanji 133002, PR China. Electronic address: .
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Źródło :
Experimental and molecular pathology [Exp Mol Pathol] 2020 Jun; Vol. 114, pp. 104406. Date of Electronic Publication: 2020 Feb 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Prognosis*
Biomarkers, Tumor/*genetics
Prostatic Neoplasms/*genetics
V-Set Domain-Containing T-Cell Activation Inhibitor 1/*genetics
Aged ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Progression-Free Survival ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/pathology
Czasopismo naukowe

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