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Wyszukujesz frazę ""T-cell receptor"" wg kryterium: Temat


Tytuł :
Memory and naïve gamma delta regulatory T-cell gene expression in the first 24-weeks of peanut oral immunotherapy.
Autorzy :
Anvari S; Baylor College of Medicine, Texas Children's Hospital, Department of Pediatrics, Section of Immunology, Allergy and Retrovirology, Houston, TX, United States of America; Texas Children's Hospital, Department of Pediatrics, William T. Shearer Center for Human Immunobiology, Houston, TX, United States of America. Electronic address: .
Watkin L; Baylor College of Medicine, Texas Children's Hospital, Department of Pediatrics, Section of Immunology, Allergy and Retrovirology, Houston, TX, United States of America; Texas Children's Hospital, Department of Pediatrics, William T. Shearer Center for Human Immunobiology, Houston, TX, United States of America.
Rajapakshe K; Baylor College of Medicine, Molecular and Cellular Biology Department, Houston, TX, United States of America; Baylor College of Medicine, Dan L Duncan Comprehensive Cancer Center, Houston, TX, United States of America.
Hassan O; Baylor College of Medicine, Texas Children's Hospital, Department of Pediatrics, Section of Immunology, Allergy and Retrovirology, Houston, TX, United States of America; Texas Children's Hospital, Department of Pediatrics, William T. Shearer Center for Human Immunobiology, Houston, TX, United States of America.
Schuster K; Baylor College of Medicine, Texas Children's Hospital, Department of Pediatrics, Section of Immunology, Allergy and Retrovirology, Houston, TX, United States of America; Texas Children's Hospital, Department of Pediatrics, William T. Shearer Center for Human Immunobiology, Houston, TX, United States of America.
Coarfa C; Baylor College of Medicine, Molecular and Cellular Biology Department, Houston, TX, United States of America; Baylor College of Medicine, Dan L Duncan Comprehensive Cancer Center, Houston, TX, United States of America; Baylor College of Medicine, Center for Precision Environmental Health, Houston, TX, United States of America. Electronic address: .
Davis CM; Baylor College of Medicine, Texas Children's Hospital, Department of Pediatrics, Section of Immunology, Allergy and Retrovirology, Houston, TX, United States of America; Texas Children's Hospital, Department of Pediatrics, William T. Shearer Center for Human Immunobiology, Houston, TX, United States of America.
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Źródło :
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2021 Sep; Vol. 230, pp. 108820. Date of Electronic Publication: 2021 Aug 06.
Typ publikacji :
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, T-Cell Receptor delta*
Genes, T-Cell Receptor gamma*
Arachis/*immunology
Desensitization, Immunologic/*methods
Peanut Hypersensitivity/*therapy
T-Lymphocytes, Regulatory/*immunology
Administration, Oral ; Allergens/administration & dosage ; Child ; Child, Preschool ; Humans ; Immunologic Memory ; Multigene Family ; Peanut Hypersensitivity/genetics ; Peanut Hypersensitivity/immunology ; RNA-Seq ; Receptors, Antigen, T-Cell, gamma-delta/immunology ; Single-Cell Analysis ; Time Factors ; Transcriptome
Czasopismo naukowe
Tytuł :
Comprehensive analysis of T-cell receptor repertoire in patients with acute coronary syndrome by high-throughput sequencing.
Autorzy :
Liu S; Clinical Core Laboratory, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, No 63 Huangtang Road, Meijiang District, Meizhou, 514031, P. R. China. .; Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, 514031, P. R. China. .
Zhong Z; Center for Precision Medicine, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizho, 514031, P. R. China.; Center for Cardiovascular Diseases, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, 514031, P. R. China.
Zhong W; Center for Precision Medicine, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizho, 514031, P. R. China.; Center for Cardiovascular Diseases, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, 514031, P. R. China.
Weng R; Clinical Core Laboratory, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, No 63 Huangtang Road, Meijiang District, Meizhou, 514031, P. R. China.; Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, 514031, P. R. China.
Liu J; Clinical Core Laboratory, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, No 63 Huangtang Road, Meijiang District, Meizhou, 514031, P. R. China.; Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, 514031, P. R. China.
Gu X; Clinical Core Laboratory, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, No 63 Huangtang Road, Meijiang District, Meizhou, 514031, P. R. China.; Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, 514031, P. R. China.
Chen Y; Clinical Core Laboratory, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, No 63 Huangtang Road, Meijiang District, Meizhou, 514031, P. R. China.; Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou, 514031, P. R. China.
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Źródło :
BMC cardiovascular disorders [BMC Cardiovasc Disord] 2020 May 27; Vol. 20 (1), pp. 253. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, T-Cell Receptor*
High-Throughput Nucleotide Sequencing*
Acute Coronary Syndrome/*genetics
Angina, Unstable/*genetics
Myocardial Infarction/*genetics
T-Lymphocytes/*immunology
Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/immunology ; Aged ; Angina, Unstable/diagnosis ; Angina, Unstable/immunology ; Case-Control Studies ; China ; Complementarity Determining Regions/genetics ; Female ; Genes, T-Cell Receptor beta/genetics ; Humans ; Immunoglobulin Variable Region ; Male ; Middle Aged ; Myocardial Infarction/diagnosis ; Myocardial Infarction/immunology
Czasopismo naukowe
Tytuł :
Evaluation of a worldwide EQA scheme for complex clonality analysis of clinical lymphoproliferative cases demonstrates a learning effect.
Autorzy :
Keppens C; Department of Public Health and Primary Care, Biomedical Quality Assurance Research Unit, University of Leuven, Kapucijnenvoer 35 block d, 1st floor, box 7001, 3000, Leuven, Belgium.
Boone E; AZ Delta vzw - Laboratorium Moleculaire Diagnostiek, Deltalaan 1, 8800, Roeselare, Belgium.
Gameiro P; Laboratory of Hemato-Oncology, Portuguese Institute of Oncology of Lisbon, Rua Prof Lima Basto, 1099-023, Lisboa, Portugal.
Tack V; Department of Public Health and Primary Care, Biomedical Quality Assurance Research Unit, University of Leuven, Kapucijnenvoer 35 block d, 1st floor, box 7001, 3000, Leuven, Belgium.
Moreau E; AZ Delta vzw - Laboratorium Moleculaire Diagnostiek, Deltalaan 1, 8800, Roeselare, Belgium.
Hodges E; Precision Medicine Centre, Queen's University Belfast, Health Science Building, 97 Lisburn Road, Belfast, BT9 7AE, UK.
Evans P; HMDS, Leeds Institute of Oncology, St. James University Hospital, Level 3 Bexley Wing Leeds, Leeds, LS9 7TF, UK.
Brüggemann M; Department of Hematology, University Hospital Schleswig-Holstein, Langer Segen 8-10, 24105, Kiel, Germany.
Carter I; Molecular Diagnostics, Histopathology, Nottingham University Hospitals NHS Trust, City Campus, Hucknall Rd., Nottingham, NG5 1PB, UK.
Lenze D; Institut für Pathologie, Molekularpathologie, Charité -Universitätsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Sarasquete ME; Laboratorio Biología Molecular, Servicio de Hematología, Hospital Universitario de Salamanca, Paseo de San Vicente, 58-182, 37007, Salamanca, Spain.
Möbs M; Institut für Pathologie, Molekularpathologie, Charité -Universitätsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Liu H; Molecular Malignancy Laboratory, Haematopathology and Oncology Diagnostic Service (HODS), Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Box 234, Hills Road, Cambridge, CB2 0QQ, UK.
Dequeker EMC; Department of Public Health and Primary Care, Biomedical Quality Assurance Research Unit, University of Leuven, Kapucijnenvoer 35 block d, 1st floor, box 7001, 3000, Leuven, Belgium.
Groenen PJTA; Department of Pathology, Radboud University Medical Centre Nijmegen, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands. .
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 Aug; Vol. 479 (2), pp. 365-376. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Comparative Study; Evaluation Study; Journal Article; Multicenter Study
MeSH Terms :
Gene Rearrangement*
Genes, Immunoglobulin*
Genes, T-Cell Receptor*
Molecular Diagnostic Techniques*
Polymerase Chain Reaction*
Lymphoproliferative Disorders/*genetics
Humans ; Laboratory Proficiency Testing ; Lymphoproliferative Disorders/immunology ; Lymphoproliferative Disorders/pathology ; Observer Variation ; Predictive Value of Tests ; Quality Assurance, Health Care ; Quality Control ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Longitudinal Analysis of the T-cell Receptor Repertoire in Graft-infiltrating Lymphocytes Following Hand Transplantation.
Autorzy :
Kim JY; Division of Infectious Diseases, Department of Medicine, University of Illinois College of Medicine Peoria, Peoria, IL.
Lei Z; Research Informatics Core, Research Resources Center, University of Illinois at Chicago, Chicago, IL.
Maienschein-Cline M; Research Informatics Core, Research Resources Center, University of Illinois at Chicago, Chicago, IL.
Chlipala GE; Research Informatics Core, Research Resources Center, University of Illinois at Chicago, Chicago, IL.
Balamurugan A; Division of Infectious Diseases, Department of Medicine, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.
McDiarmid SV; Department of Pediatrics, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.; Department of Surgery, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.
Azari K; Department of Surgery, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.; Department of Orthopaedic Surgery, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.
Yang OO; Division of Infectious Diseases, Department of Medicine, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.; Department of Microbiology, Immunology, and Molecular Genetics, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.
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Źródło :
Transplantation [Transplantation] 2021 Jul 01; Vol. 105 (7), pp. 1502-1509.
Typ publikacji :
Case Reports
MeSH Terms :
Genes, T-Cell Receptor*
Hand Transplantation*/adverse effects
Immunity, Cellular*
Skin Transplantation*/adverse effects
Graft Rejection/*genetics
T-Lymphocytes/*immunology
Graft Rejection/immunology ; Graft Rejection/metabolism ; Graft Survival ; Hand ; Humans ; Immunogenetic Phenomena ; Male ; Middle Aged ; T-Lymphocytes/metabolism ; Time Factors ; Treatment Outcome
Raport
Tytuł :
Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19.
Autorzy :
You M; Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing, China.; Chongqing International Institute for Immunology, Chongqing, China.
Chen L; Department of Immunology and Microbiology, Stanford University, Stanford, CA, USA. .; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA. .; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA. .; School of Medicine, Shanghai University, Shanghai, China. .
Zhang D; The Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Zhao P; The Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Chen Z; The Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Qin EQ; The Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Gao Y; Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing, China.; Chongqing International Institute for Immunology, Chongqing, China.
Davis MM; Department of Immunology and Microbiology, Stanford University, Stanford, CA, USA. .; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA. .; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA. .
Yang P; Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing, China. .; Chongqing International Institute for Immunology, Chongqing, China. .
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Źródło :
Nature cell biology [Nat Cell Biol] 2021 Jun; Vol. 23 (6), pp. 620-630. Date of Electronic Publication: 2021 Jun 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Epigenomics*
Genes, T-Cell Receptor*
Immunologic Memory*
Single-Cell Analysis*
COVID-19/*genetics
Lymphocyte Subsets/*immunology
Monocytes/*immunology
SARS-CoV-2/*immunology
Adaptive Immunity ; Adolescent ; Adult ; Aged ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; B-Lymphocytes/virology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/virology ; COVID-19/immunology ; COVID-19/metabolism ; COVID-19/virology ; Case-Control Studies ; Cell Differentiation ; Chromatin Assembly and Disassembly ; Female ; Gene Expression Profiling ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Lymphocyte Subsets/metabolism ; Lymphocyte Subsets/virology ; Male ; Middle Aged ; Monocytes/metabolism ; Monocytes/virology ; SARS-CoV-2/pathogenicity ; Young Adult
Czasopismo naukowe
Tytuł :
Xenograft and cell culture models of Sézary syndrome reveal cell of origin diversity and subclonal heterogeneity.
Autorzy :
Poglio S; Univ. Bordeaux, INSERM, BaRITOn, U1053, F-33000, Bordeaux, France. .
Prochazkova-Carlotti M; Univ. Bordeaux, INSERM, BaRITOn, U1053, F-33000, Bordeaux, France.
Cherrier F; Univ. Bordeaux, INSERM, BaRITOn, U1053, F-33000, Bordeaux, France.
Gros A; Univ. Bordeaux, INSERM, BaRITOn, U1053, F-33000, Bordeaux, France.; Tumor Bank and Tumor Biology Laboratory, CHU Bordeaux, F-33000, Bordeaux, France.
Laharanne E; Tumor Bank and Tumor Biology Laboratory, CHU Bordeaux, F-33000, Bordeaux, France.
Pham-Ledard A; Univ. Bordeaux, INSERM, BaRITOn, U1053, F-33000, Bordeaux, France.; Dermatology Department, CHU Bordeaux, F-33000, Bordeaux, France.
Beylot-Barry M; Univ. Bordeaux, INSERM, BaRITOn, U1053, F-33000, Bordeaux, France.; Dermatology Department, CHU Bordeaux, F-33000, Bordeaux, France.
Merlio JP; Univ. Bordeaux, INSERM, BaRITOn, U1053, F-33000, Bordeaux, France. .; Tumor Bank and Tumor Biology Laboratory, CHU Bordeaux, F-33000, Bordeaux, France. .
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Źródło :
Leukemia [Leukemia] 2021 Jun; Vol. 35 (6), pp. 1696-1709. Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, T-Cell Receptor*
Clone Cells/*pathology
Sezary Syndrome/*pathology
Skin Neoplasms/*pathology
Adult ; Animals ; Apoptosis ; Cell Culture Techniques ; Cell Proliferation ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Prognosis ; Sezary Syndrome/genetics ; Skin Neoplasms/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Characterization and Monitoring of Antigen-Responsive T Cell Clones Using T Cell Receptor Gene Expression Analysis.
Autorzy :
Pollastro S; Department of Clinical Immunology & Rheumatology, Amsterdam Rheumatology and Immunology Centre (ARC), Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AIII), Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands.
de Bourayne M; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé, SIMoS, Gif-sur-Yvette, France.
Balzaretti G; Department of Clinical Immunology & Rheumatology, Amsterdam Rheumatology and Immunology Centre (ARC), Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AIII), Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands.
Jongejan A; Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Amsterdam Infection & Immunity Institute (AIII), Amsterdam Public Health Research Institute, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands.
van Schaik BDC; Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Amsterdam Infection & Immunity Institute (AIII), Amsterdam Public Health Research Institute, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands.
Niewold ITG; Department of Clinical Immunology & Rheumatology, Amsterdam Rheumatology and Immunology Centre (ARC), Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands.
van Kampen AHC; Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Amsterdam Infection & Immunity Institute (AIII), Amsterdam Public Health Research Institute, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands.
Maillère B; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé, SIMoS, Gif-sur-Yvette, France.
de Vries N; Department of Clinical Immunology & Rheumatology, Amsterdam Rheumatology and Immunology Centre (ARC), Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AIII), Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Feb 19; Vol. 11, pp. 609624. Date of Electronic Publication: 2021 Feb 19 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens/*immunology
Clone Cells/*immunology
Gene Expression/*immunology
Genes, T-Cell Receptor/*immunology
Receptors, Antigen, T-Cell/*immunology
T-Lymphocytes/*immunology
Antigens/genetics ; Gene Expression/genetics ; Genes, T-Cell Receptor/genetics ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Interleukin-4/genetics ; Interleukin-4/immunology ; Receptors, Antigen, T-Cell/genetics
Czasopismo naukowe
Tytuł :
TCRβ Sequencing Reveals Spatial and Temporal Evolution of Clonal CD4 T Cell Responses in a Breach of Tolerance Model of Inflammatory Arthritis.
Autorzy :
Al Khabouri S; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Benson RA; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Prendergast CT; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Gray JI; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Otto TD; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Brewer JM; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Garside P; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Apr 27; Vol. 12, pp. 669856. Date of Electronic Publication: 2021 Apr 27 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Clonal Evolution*
Genes, T-Cell Receptor beta*
Self Tolerance*/genetics
Arthritis, Experimental/*immunology
CD4-Positive T-Lymphocytes/*immunology
Joints/*immunology
Lymph Nodes/*immunology
Animals ; Arthritis, Experimental/genetics ; Arthritis, Experimental/metabolism ; CD4-Positive T-Lymphocytes/metabolism ; Disease Progression ; Female ; Joints/metabolism ; Lymph Nodes/metabolism ; Male ; Mice, Inbred C57BL ; Phenotype ; Time Factors
Czasopismo naukowe
Tytuł :
T Cell Receptor Repertoires Acquired via Routine Pap Testing May Help Refine Cervical Cancer and Precancer Risk Estimates.
Autorzy :
Christley S; Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, United States.
Ostmeyer J; Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, United States.
Quirk L; Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, United States.
Zhang W; Department of Neurology and Neurotherapeutics, Department of Immunology, UT Southwestern Medical Center, Dallas, TX, United States.
Sirak B; Center for Immunization and Infection Research, Moffitt Cancer Center, Tampa, FL, United States.
Giuliano AR; Center for Immunization and Infection Research, Moffitt Cancer Center, Tampa, FL, United States.
Zhang S; Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, United States.
Monson N; Department of Neurology and Neurotherapeutics, Department of Immunology, UT Southwestern Medical Center, Dallas, TX, United States.
Tiro J; Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, United States.
Lucas E; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, United States.; Department of Pathology, Parkland Health and Hospital System, Dallas, TX, United States.
Cowell LG; Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, United States.; Department of Neurology and Neurotherapeutics, Department of Immunology, UT Southwestern Medical Center, Dallas, TX, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Apr 02; Vol. 12, pp. 624230. Date of Electronic Publication: 2021 Apr 02 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Early Detection of Cancer*
Genes, T-Cell Receptor beta*
Papanicolaou Test*
Vaginal Smears*
Alphapapillomavirus/*immunology
Papillomavirus Infections/*diagnosis
Precancerous Conditions/*diagnosis
T-Lymphocytes/*immunology
Uterine Cervical Neoplasms/*diagnosis
Adult ; Alphapapillomavirus/genetics ; Alphapapillomavirus/pathogenicity ; Complementarity Determining Regions/genetics ; Female ; Gene Expression Profiling ; High-Throughput Nucleotide Sequencing ; Human Papillomavirus DNA Tests ; Humans ; Machine Learning ; Middle Aged ; Papillomavirus Infections/immunology ; Papillomavirus Infections/virology ; Precancerous Conditions/immunology ; Precancerous Conditions/virology ; Predictive Value of Tests ; Proof of Concept Study ; Reproducibility of Results ; Risk Assessment ; Risk Factors ; T-Lymphocytes/virology ; Transcriptome ; Uterine Cervical Neoplasms/immunology ; Uterine Cervical Neoplasms/virology
Czasopismo naukowe
Tytuł :
Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+ T Lymphocyte Signature.
Autorzy :
Kelkka T; Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland.; Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Savola P; Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland.; Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Bhattacharya D; Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland.; Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Huuhtanen J; Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland.; Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Lönnberg T; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Kankainen M; Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland.; Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Paalanen K; Rheumatology, Jyväskylä Central Hospital, Jyväskylä, Finland.
Tyster M; Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland.; Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Lepistö M; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.
Ellonen P; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.
Smolander J; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Eldfors S; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.
Yadav B; Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland.; Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Khan S; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Koivuniemi R; Rheumatology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
Sjöwall C; Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, Sweden.
Elo LL; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.; Institute of Biomedicine, University of Turku, Turku, Finland.
Lähdesmäki H; Department of Computer Science, Aalto University School of Science, Espoo, Finland.
Maeda Y; Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Tokyo, Japan.
Nishikawa H; Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Tokyo, Japan.
Leirisalo-Repo M; Rheumatology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
Sokka-Isler T; Rheumatology, Jyväskylä Central Hospital, Jyväskylä, Finland.; University of Eastern Finland, Faculty of Health Sciences, Kuopio, Finland.
Mustjoki S; Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland.; Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Nov 19; Vol. 11, pp. 578848. Date of Electronic Publication: 2020 Nov 19 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, T-Cell Receptor*
Transcriptome*
Anti-Citrullinated Protein Antibodies/*blood
Arthritis, Rheumatoid/*genetics
Cytokines/*genetics
T-Lymphocytes, Cytotoxic/*metabolism
Adolescent ; Adult ; Aged ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/immunology ; Biomarkers/blood ; Case-Control Studies ; Cytokines/metabolism ; Female ; Gene Expression Profiling ; Humans ; Male ; Middle Aged ; Mutation ; Phenotype ; RNA-Seq ; Severity of Illness Index ; Single-Cell Analysis ; T-Lymphocytes, Cytotoxic/immunology ; Whole Exome Sequencing ; Young Adult
Czasopismo naukowe
Tytuł :
Regulation of T-cell Receptor Gene Expression by Three-Dimensional Locus Conformation and Enhancer Function.
Autorzy :
Rodríguez-Caparrós A; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
Álvarez-Santiago J; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
Del Valle-Pastor MJ; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
Suñé C; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
López-Ros J; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
Hernández-Munain C; Institute of Parasitology and Biomedicine 'López-Neyra'-Spanish Scientific Research Council (IPBLN-CSIC), Parque Tecnológico de Ciencias de la Salud (PTS), 18016 Granada, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 11; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Enhancer Elements, Genetic/*genetics
Gene Expression Regulation/*genetics
Genes, T-Cell Receptor/*genetics
T-Lymphocytes/*immunology
Animals ; Chromatin/genetics ; Chromatin/immunology ; Enhancer Elements, Genetic/immunology ; Gene Expression Regulation/immunology ; Genes, T-Cell Receptor/immunology ; Humans ; Signal Transduction/genetics ; Signal Transduction/immunology ; Transcription, Genetic/genetics ; Transcription, Genetic/immunology ; V(D)J Recombination/genetics ; V(D)J Recombination/immunology
Czasopismo naukowe
Tytuł :
The clinical characteristics of autoimmune haemolytic anaemia/Evans syndrome patients with clonal immunoglobulin/T cell receptor gene rearrangement.
Autorzy :
Zhu H; Department of Hematology, Jining No. 1 People's Hospital, Shandong, China.
Zhao M; Department of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Cao Z; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Department of Hematology and Blood and Marrow Transplantation, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Yang J; Department of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Li Y; Department of Hematology, Jining No. 1 People's Hospital, Shandong, China.
Xing L; Department of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
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Źródło :
Autoimmunity [Autoimmunity] 2020 Nov; Vol. 53 (7), pp. 394-399. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Rearrangement, B-Lymphocyte*
Gene Rearrangement, T-Lymphocyte*
Genes, T-Cell Receptor*
Immunoglobulins*
Anemia, Hemolytic, Autoimmune/*diagnosis
Anemia, Hemolytic, Autoimmune/*etiology
Thrombocytopenia/*diagnosis
Thrombocytopenia/*etiology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Immunophenotyping ; Male ; Middle Aged ; Young Adult
SCR Disease Name :
Evans Syndrome
Czasopismo naukowe
Tytuł :
The expansion of the TRB and TRG genes in domestic goats (Capra hircus) is characteristic of the ruminant species.
Autorzy :
Giannico F; Department of Veterinary Medicine, University of Bari 'Aldo Moro', Bari, Italy.
Massari S; Department of Biological and Environmental Science and Technologies, University of Salento, Lecce, Italy.
Caputi Jambrenghi A; Department of Agricultural and Environmental Science, University of Bari 'Aldo Moro', Bari, Italy.
Soriano A; Department of Biology, University of Bari 'Aldo Moro', 70124, Bari, Italy.
Pala A; Department of Biology, University of Bari 'Aldo Moro', 70124, Bari, Italy.
Linguiti G; Department of Biology, University of Bari 'Aldo Moro', 70124, Bari, Italy.
Ciccarese S; Department of Biology, University of Bari 'Aldo Moro', 70124, Bari, Italy.
Antonacci R; Department of Biology, University of Bari 'Aldo Moro', 70124, Bari, Italy. .
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Źródło :
BMC genomics [BMC Genomics] 2020 Sep 11; Vol. 21 (1), pp. 623. Date of Electronic Publication: 2020 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Evolution, Molecular*
Genes, T-Cell Receptor beta*
Genes, T-Cell Receptor gamma*
Goats/*genetics
Animals ; Gene Dosage ; Goats/classification ; Phylogeny
Czasopismo naukowe
Tytuł :
TRBV and TRBJ usage, when paired with specific HLA alleles, associates with distinct head and neck cancer survival rates.
Autorzy :
Arndt MF; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Koohestani DM; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Chobrutskiy BI; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Mihyu MM; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Diaz M; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Gozlan EC; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Yeagley M; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Zaman S; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Roca AM; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States.
Blanck G; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States. Electronic address: .
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Źródło :
Human immunology [Hum Immunol] 2020 Dec; Vol. 81 (12), pp. 692-696. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
Alleles*
Genes, T-Cell Receptor beta*
V(D)J Recombination*
HLA Antigens/*genetics
Head and Neck Neoplasms/*genetics
Head and Neck Neoplasms/*mortality
Histocompatibility Antigens Class I/*genetics
Histocompatibility Antigens Class II/*genetics
Receptors, Antigen, T-Cell, alpha-beta/*genetics
Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Disease-Free Survival ; Exome ; Head and Neck Neoplasms/blood ; Head and Neck Neoplasms/pathology ; Humans ; Kaplan-Meier Estimate ; Prognosis ; Survival Rate
Czasopismo naukowe
Tytuł :
NetTCR-2.0 enables accurate prediction of TCR-peptide binding by using paired TCRα and β sequence data.
Autorzy :
Montemurro, Alessandro
Schuster, Viktoria
Povlsen, Helle Rus
Bentzen, Amalie Kai
Jurtz, Vanessa
Chronister, William D.
Crinklaw, Austin
Hadrup, Sine R.
Winther, Ole
Peters, Bjoern
Jessen, Leon Eyrich
Nielsen, Morten
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Źródło :
Communications Biology. 9/10/2021, Vol. 4 Issue 1, p1-13. 13p.
Czasopismo naukowe
Tytuł :
The MAIT TCRβ chain contributes to discrimination of microbial ligand.
Autorzy :
Narayanan GA; Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, USA.
McLaren JE; Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK.
Meermeier EW; Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, USA.
Ladell K; Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK.
Swarbrick GM; Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, USA.; VA Portland Health Care Center, Portland, OR, USA.
Price DA; Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK.; Systems Immunity Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff, UK.
Tran JG; VA Portland Health Care Center, Portland, OR, USA.
Worley AH; VA Portland Health Care Center, Portland, OR, USA.
Vogt T; VA Portland Health Care Center, Portland, OR, USA.
Wong EB; Africa Health Research Institute, Durban, South Africa.; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Lewinsohn DM; Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, USA.; VA Portland Health Care Center, Portland, OR, USA.
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Źródło :
Immunology and cell biology [Immunol Cell Biol] 2020 Oct; Vol. 98 (9), pp. 770-781. Date of Electronic Publication: 2020 Jul 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Genes, T-Cell Receptor beta*
Lymphocyte Activation*
Mucosal-Associated Invariant T Cells*/immunology
Bacterial Infections/*immunology
Complementarity Determining Regions/*genetics
Humans ; Ligands ; Ribitol/analogs & derivatives ; Uracil/analogs & derivatives
Czasopismo naukowe
Tytuł :
T cell receptor gene recombinations in human tumor specimen exome files: detection of T cell receptor-β VDJ recombinations associates with a favorable oncologic outcome for bladder cancer.
Autorzy :
Samy MD; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Bd., Tampa, FL, 33612, USA.
Tong WL; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Bd., Tampa, FL, 33612, USA.
Yavorski JM; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Bd., Tampa, FL, 33612, USA.
Sexton WJ; Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Blanck G; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Bd., Tampa, FL, 33612, USA. .; Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2017 Mar; Vol. 66 (3), pp. 403-410. Date of Electronic Publication: 2016 Dec 19.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, T-Cell Receptor*
Receptors, Antigen, T-Cell, alpha-beta/*genetics
Urinary Bladder Neoplasms/*genetics
V(D)J Recombination/*genetics
Exome ; Genes, T-Cell Receptor beta ; Humans ; Treatment Outcome ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Identification of Disease-associated Traits and Clonotypes in the T Cell Receptor Repertoire of Monozygotic Twins Affected by Inflammatory Bowel Diseases.
Autorzy :
Rosati E; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Pogorelyy MV; Laboratory of comparative and functional genomic, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation.; Department of Translational Medicine, Pirogov Russian National Research Medical University [RNRMU], Moscow, Russian Federation.
Dowds CM; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Moller FT; Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Sorensen SB; Focused Research Unit for Molecular Diagnostic and Clinical Research, University Hospital of Southern Denmark, Aabenraa, Denmark.; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Lebedev YB; Laboratory of comparative and functional genomic, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation.
Frey N; Department of Internal Medicine III, University Hospital Schleswig-Holstein, Kiel, Germany.
Schreiber S; Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany.
Spehlmann ME; Department of Internal Medicine III, University Hospital Schleswig-Holstein, Kiel, Germany.
Andersen V; Focused Research Unit for Molecular Diagnostic and Clinical Research, University Hospital of Southern Denmark, Aabenraa, Denmark.; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; IRS-Center Sønderjylland, University of Southern Denmark, Odense, Denmark.
Mamedov IZ; Laboratory of comparative and functional genomic, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation.; Department of Translational Medicine, Pirogov Russian National Research Medical University [RNRMU], Moscow, Russian Federation.; Laboratory of molecular biology, Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation.; CEITEC, Masaryk University, Brno, Czech Republic.
Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
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Źródło :
Journal of Crohn's & colitis [J Crohns Colitis] 2020 Jul 09; Vol. 14 (6), pp. 778-790.
Typ publikacji :
Journal Article; Twin Study
MeSH Terms :
Colitis, Ulcerative*/diagnosis
Colitis, Ulcerative*/immunology
Colitis, Ulcerative*/physiopathology
Crohn Disease*/diagnosis
Crohn Disease*/immunology
Crohn Disease*/physiopathology
Genes, T-Cell Receptor alpha*
Genes, T-Cell Receptor beta*
Receptors, Antigen, T-Cell, alpha-beta/*blood
Adult ; C-Reactive Protein/analysis ; Denmark ; Feces ; Female ; Germany ; Humans ; Leukocyte L1 Antigen Complex/analysis ; Male ; Patient Acuity ; Sequence Analysis, DNA ; Smoking/immunology ; Twins, Monozygotic
Czasopismo naukowe

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