Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases.
Autorzy :
Biechele G; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany. Franzmeier N; Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, Munich, Germany. BlumeT; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany. Ewers M; Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, Munich, Germany.; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany. Luque JM; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany. Eckenweber F; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany. Sacher C; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany. Beyer L; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany. Ruch-Rubinstein F; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany. Lindner S; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany. Gildehaus FJ; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany. von Ungern-Sternberg B; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany. Cumming P; Department of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland.; School of Psychology and Counselling, Queensland University of Technology, Brisbane, Australia. Bartenstein P; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.; Department of Neurology, Hannover Medical School, Hannover, Germany. Rominger A; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.; Department of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland. Höglinger GU; Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, Munich, Germany.; Department of Neurology, Technical University Munich, Munich, Germany.; Center of Neuropathology and Prion Research, University of Munich, Munich, Germany. Herms J; Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Department of Neurology, Hannover Medical School, Hannover, Germany. Brendel M; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany. .; Department of Neurology, Hannover Medical School, Hannover, Germany. .
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Źródło :
Journal of neuroinflammation [J Neuroinflammation] 2020 Dec 14; Vol. 17 (1), pp. 374. Date of Electronic Publication: 2020 Dec 14.
Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning.
Autorzy :
Eckenweber F; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377, Munich, Germany. Medina-Luque J; Center of Neuropathology and Prion Research, University Hospital of Munich, LMU Munich, 81377, Munich, Germany. BlumeT; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377, Munich, Germany.; Center of Neuropathology and Prion Research, University Hospital of Munich, LMU Munich, 81377, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377, Munich, Germany. Sacher C; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377, Munich, Germany. Biechele G; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377, Munich, Germany. Wind K; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377, Munich, Germany. Deussing M; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377, Munich, Germany. Briel N; Center of Neuropathology and Prion Research, University Hospital of Munich, LMU Munich, 81377, Munich, Germany. Lindner S; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377, Munich, Germany. Boening G; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377, Munich, Germany. von Ungern-Sternberg B; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377, Munich, Germany. Unterrainer M; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377, Munich, Germany. Albert NL; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377, Munich, Germany. Zwergal A; German Center for Vertigo and Balance Disorders, DSGZ, University Hospital of Munich, LMU Munich, 81377, Munich, Germany.; Department of Neurology, University Hospital of Munich, LMU Munich, 81377, Munich, Germany. Levin J; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377, Munich, Germany.; Department of Neurology, University Hospital of Munich, LMU Munich, 81377, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377, Munich, Germany. Bartenstein P; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377, Munich, Germany. Cumming P; Department of Nuclear Medicine, Inselspital Bern, Bern, Switzerland.; School of Psychology and Counselling and IHBI, Queensland University of Technology, Brisbane, Australia. Rominger A; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377, Munich, Germany.; Department of Nuclear Medicine, Inselspital Bern, Bern, Switzerland. Höglinger GU; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377, Munich, Germany.; Department of Neurology, Hannover Medical School, Hannover, Germany.; Department of Neurology, Technical University of Munich, Munich, Germany. Herms J; Center of Neuropathology and Prion Research, University Hospital of Munich, LMU Munich, 81377, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377, Munich, Germany. Brendel M; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377, Munich, Germany. .; Munich Cluster for Systems Neurology (SyNergy), 81377, Munich, Germany. .
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Źródło :
Journal of neuroinflammation [J Neuroinflammation] 2020 Jul 13; Vol. 17 (1), pp. 208. Date of Electronic Publication: 2020 Jul 13.
Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study.
Autorzy :
BlumeT; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany. Focke C; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany. Peters F; German Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany. Deussing M; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany. Albert NL; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany. Lindner S; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany. Gildehaus FJ; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany. von Ungern-Sternberg B; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany. Ozmen L; Roche, Pharma Research and Early Development, NORD DTA / Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, CH-4070, Basel, Switzerland. Baumann K; Roche, Pharma Research and Early Development, NORD DTA / Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, CH-4070, Basel, Switzerland. Bartenstein P; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany. Rominger A; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.; Department of Nuclear Medicine, Inselspital, University Hospital Bern, Freiburgstrasse 4, 3010, Bern, Switzerland.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Herms J; German Center for Neurodegenerative Diseases (DZNE) Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Center of Neuropathology and Prion Research, Feodor-Lynen-Straße 23, 81377, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Brendel M; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany. .; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. .
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Źródło :
Journal of neuroinflammation [J Neuroinflammation] 2018 Nov 06; Vol. 15 (1), pp. 307. Date of Electronic Publication: 2018 Nov 06.
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