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Tytuł :
Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils.
Autorzy :
Chakraborty P; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Rivière G; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Liu S; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
de Opakua AI; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
Dervişoğlu R; Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Hebestreit A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Andreas LB; Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Vorberg IM; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
Zweckstetter M; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany. .; Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 09; Vol. 12 (1), pp. 4231. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid/*metabolism
Protein Aggregation, Pathological/*pathology
RNA/*metabolism
tau Proteins/*metabolism
Amyloid/ultrastructure ; Biosensing Techniques ; Humans ; Nuclear Magnetic Resonance, Biomolecular ; RNA/ultrastructure ; RNA, Fungal/metabolism ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Recombinant Proteins/ultrastructure ; tau Proteins/isolation & purification ; tau Proteins/ultrastructure
Czasopismo naukowe
Tytuł :
How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders.
Autorzy :
Carlson GA; Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA.; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA.
Prusiner SB; Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA.; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 04; Vol. 22 (9). Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease/*genetics
Amyloid beta-Peptides/*genetics
Prion Proteins/*genetics
Scrapie/*genetics
alpha-Synuclein/*genetics
tau Proteins/*genetics
Alzheimer Disease/etiology ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/chemistry ; Amyloid beta-Peptides/metabolism ; Animals ; Creutzfeldt-Jakob Syndrome/etiology ; Creutzfeldt-Jakob Syndrome/genetics ; Creutzfeldt-Jakob Syndrome/metabolism ; Creutzfeldt-Jakob Syndrome/pathology ; Frontotemporal Dementia/etiology ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/metabolism ; Frontotemporal Dementia/pathology ; Gene Expression ; Gerstmann-Straussler-Scheinker Disease/etiology ; Gerstmann-Straussler-Scheinker Disease/genetics ; Gerstmann-Straussler-Scheinker Disease/metabolism ; Gerstmann-Straussler-Scheinker Disease/pathology ; Humans ; Mice ; Mutation ; Parkinson Disease/etiology ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Prion Proteins/chemistry ; Prion Proteins/metabolism ; Prions ; Protein Folding ; Scrapie/etiology ; Scrapie/metabolism ; Scrapie/pathology ; Sheep ; alpha-Synuclein/chemistry ; alpha-Synuclein/metabolism ; tau Proteins/chemistry ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Relationship between amyloid and tau levels and its impact on tau spreading.
Autorzy :
Doré V; Health and Biosecurity Flagship, The Australian eHealth Research Centre, Melbourne, Victoria, Australia. .; Department of Molecular Imaging & Therapy, Austin Health, LVL1 Harrold STOKES Block, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia. .
Krishnadas N; Department of Molecular Imaging & Therapy, Austin Health, LVL1 Harrold STOKES Block, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.
Bourgeat P; Health and Biosecurity Flagship, The Australian eHealth Research Centre, Brisbane, Queensland, Australia.
Huang K; Department of Molecular Imaging & Therapy, Austin Health, LVL1 Harrold STOKES Block, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.
Li S; Health and Biosecurity Flagship, The Australian eHealth Research Centre, Melbourne, Victoria, Australia.; Department of Molecular Imaging & Therapy, Austin Health, LVL1 Harrold STOKES Block, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.
Burnham S; Health and Biosecurity Flagship, The Australian eHealth Research Centre, Melbourne, Victoria, Australia.
Masters CL; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia.
Fripp J; Health and Biosecurity Flagship, The Australian eHealth Research Centre, Brisbane, Queensland, Australia.
Villemagne VL; Department of Molecular Imaging & Therapy, Austin Health, LVL1 Harrold STOKES Block, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.
Rowe CC; Department of Molecular Imaging & Therapy, Austin Health, LVL1 Harrold STOKES Block, 145 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia.; Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.; The Australian Dementia Network (ADNeT), Melbourne, Australia.
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Źródło :
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2021 Jul; Vol. 48 (7), pp. 2225-2232. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*
tau Proteins*
Amyloid ; Amyloid beta-Peptides ; Humans ; Magnetic Resonance Imaging ; Positron-Emission Tomography
Czasopismo naukowe
Tytuł :
Adult neurogenic process in the subventricular zone-olfactory bulb system is regulated by Tau protein under prolonged stress.
Autorzy :
Dioli C; School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.; Institute of Biology Paris Seine, Team Gene Regulation and Adaptive Behaviors, Department of Neurosciences Paris Seine, Sorbonne Université, CNRS UMR 8246, INSERM U1130, Paris, France.
Patrício P; School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Pinto LG; School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Marie C; School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Morais M; School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Vyas S; Institute of Biology Paris Seine, Team Gene Regulation and Adaptive Behaviors, Department of Neurosciences Paris Seine, Sorbonne Université, CNRS UMR 8246, INSERM U1130, Paris, France.
Bessa JM; School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Pinto L; School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Sotiropoulos I; School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
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Źródło :
Cell proliferation [Cell Prolif] 2021 Jul; Vol. 54 (7), pp. e13027. Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article
MeSH Terms :
Stress, Physiological*
Lateral Ventricles/*metabolism
Olfactory Bulb/*metabolism
tau Proteins/*metabolism
Animals ; Behavior, Animal ; Cell Proliferation ; Cell Survival ; Lateral Ventricles/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Neurogenesis ; Olfactory Bulb/pathology ; Oligodendroglia/cytology ; Oligodendroglia/metabolism ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia.
Autorzy :
Salvadó G; Alzheimer Prevention Program, Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ Wellington, 30 08005, Barcelona, Spain. .; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. .; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. .
Grothe MJ; Wallenberg Centre for Molecular and Translational Medicine, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. .; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Avda. Manuel Siurot, s/n 41013, Seville, Spain. .
Groot C; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Moscoso A; Wallenberg Centre for Molecular and Translational Medicine, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Schöll M; Wallenberg Centre for Molecular and Translational Medicine, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.; Dementia Research Centre, Institute of Neurology, University College London, London, UK.
Gispert JD; Alzheimer Prevention Program, Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ Wellington, 30 08005, Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain.
Ossenkoppele R; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Clinical Memory Research Unit, Lund University, Lund, Sweden.
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Corporate Authors :
Alzheimer’s Disease Neuroimaging Initiative
Źródło :
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2021 Jul; Vol. 48 (7), pp. 2212-2224. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/genetics
tau Proteins*/genetics
Aged ; Alleles ; Amyloid beta-Peptides/genetics ; Apolipoprotein E2/genetics ; Apolipoprotein E4/genetics ; Cross-Sectional Studies ; Genotype ; Humans ; Positron-Emission Tomography
Czasopismo naukowe
Tytuł :
Indication of retrograde tau spreading along Braak stages and functional connectivity pathways.
Autorzy :
Seemiller J; Department of Neurology, Geisinger Medical Center, 100 N. Academy Ave, Danville, PA, 17822, USA. .
Bischof GN; Multimodal Neuroimaging Group, Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.
Hoenig MC; Multimodal Neuroimaging Group, Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.; Molecular Organization of the Brain, Institute of Neuroscience and Medicine 2, Research Center Juelich, Jülich, 52428, Germany.
Tahmasian M; Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran.
van Eimeren T; Multimodal Neuroimaging Group, Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn/Cologne, Germany.
Drzezga A; Multimodal Neuroimaging Group, Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.; Molecular Organization of the Brain, Institute of Neuroscience and Medicine 2, Research Center Juelich, Jülich, 52428, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn/Cologne, Germany.
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Corporate Authors :
Alzheimer’s Disease Neuroimaging Initiative
Źródło :
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2021 Jul; Vol. 48 (7), pp. 2272-2282. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Alzheimer Disease*/diagnostic imaging
tau Proteins*/metabolism
Brain/diagnostic imaging ; Brain/metabolism ; Humans ; Neuroimaging ; Positron-Emission Tomography
Czasopismo naukowe
Tytuł :
Histidine Tautomeric Effect on the Key Fragment R3 of Tau Protein from Atomistic Simulations.
Autorzy :
Li H; Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
Li N; Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
Tang Y; Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
Lee JY; Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Jun 02; Vol. 12 (11), pp. 1983-1988. Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*
tau Proteins*/metabolism
Histidine ; Humans ; Molecular Dynamics Simulation ; Neurofibrillary Tangles/metabolism
Czasopismo naukowe
Tytuł :
UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation.
Autorzy :
Subramanian M; Metabolism and Neurophysiology Research Group, KRIBB, Daejeon, Korea.; Convergence Research Center of Dementia, KIST, Seoul, Korea.
Hyeon SJ; Center for Neuroscience, Brain Science Institute, KIST, Seoul, Korea.
Das T; Biomedical Research Institute, KIST, Seoul, Korea.
Suh YS; Metabolism and Neurophysiology Research Group, KRIBB, Daejeon, Korea.
Kim YK; Convergence Research Center of Dementia, KIST, Seoul, Korea.
Lee JS; Metabolism and Neurophysiology Research Group, KRIBB, Daejeon, Korea.; Convergence Research Center of Dementia, KIST, Seoul, Korea.
Song EJ; Graduate School of Pharmaceutical Sciences and College of Pharmacy, Ewha Womans University, Seoul, Korea. .
Ryu H; Center for Neuroscience, Brain Science Institute, KIST, Seoul, Korea. .
Yu K; Metabolism and Neurophysiology Research Group, KRIBB, Daejeon, Korea. .; Convergence Research Center of Dementia, KIST, Seoul, Korea. .; Department of Functional Genomics, UST, Daejeon, Korea. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 02; Vol. 12 (1), pp. 3291. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*genetics
Drosophila Proteins/*genetics
MicroRNAs/*genetics
Ubiquitin-Protein Ligases/*genetics
tau Proteins/*genetics
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Animals ; Autophagy/genetics ; Brain/metabolism ; Brain/pathology ; Cell Line, Tumor ; Disease Models, Animal ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Eye/metabolism ; Eye/pathology ; Humans ; Lysosomes/metabolism ; Mice ; MicroRNAs/metabolism ; Neurons/metabolism ; Neurons/pathology ; Phosphorylation ; Proteasome Endopeptidase Complex/metabolism ; Protein Processing, Post-Translational ; Proteolysis ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models.
Autorzy :
McMurray L; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Macdonald JA; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Ramakrishnan NK; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Zhao Y; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Williamson DW; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Tietz O; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Zhou X; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Kealey S; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Fagan SG; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Smolek T; Axon Neuroscience R&D Services SE, Bratislava, Slovak Republic 811 02.
Cubinkova V; Axon Neuroscience R&D Services SE, Bratislava, Slovak Republic 811 02.
Žilka N; Axon Neuroscience R&D Services SE, Bratislava, Slovak Republic 811 02.
Spillantini MG; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Tolkovsky AM; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Goedert M; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Aigbirhio FI; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Jun 02; Vol. 12 (11), pp. 1885-1893. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*/diagnostic imaging
tau Proteins*/metabolism
Animals ; Brain/diagnostic imaging ; Brain/metabolism ; Mice ; Mice, Transgenic ; Neurofibrillary Tangles/metabolism ; Positron-Emission Tomography ; Rats ; Rats, Transgenic
Czasopismo naukowe
Tytuł :
PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain.
Autorzy :
Schaler AW; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Runyan AM; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Clelland CL; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Sydney EJ; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Fowler SL; U.K. Dementia Research Institute, University College London, London WC1E 6BT, UK.
Figueroa HY; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Shioda S; Innovative Drug Discovery, Global Research Center for Innovative Life Science, Hoshi University, Tokyo 142-8501, Japan.
Santa-Maria I; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Duff KE; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.; U.K. Dementia Research Institute, University College London, London WC1E 6BT, UK.
Myeku N; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA. .; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
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Źródło :
Science translational medicine [Sci Transl Med] 2021 May 26; Vol. 13 (595).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Tauopathies*/drug therapy
tau Proteins*/metabolism
Animals ; Brain/metabolism ; Disease Models, Animal ; Humans ; Mice ; Mice, Transgenic ; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
Czasopismo naukowe
Tytuł :
Characterization of a Mouse Model of Alzheimer's Disease Expressing Aβ4-42 and Human Mutant Tau.
Autorzy :
Zampar S; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, D-37075 Göttingen, Germany.
Wirths O; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, D-37075 Göttingen, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 14; Vol. 22 (10). Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Mutation*
Alzheimer Disease/*complications
Amyloid beta-Peptides/*metabolism
Memory Disorders/*etiology
Motor Disorders/*etiology
tau Proteins/*genetics
Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Animals ; Behavior, Animal ; Female ; Humans ; Male ; Memory Disorders/metabolism ; Memory Disorders/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Motor Disorders/metabolism ; Motor Disorders/pathology ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Pathological drivers of neurodegeneration in suspected non-Alzheimer's disease pathophysiology.
Autorzy :
Wisse LEM; Department of Diagnostic Radiology, Lund University, Remissgatan 4, Room 14-520, 222 42, Lund, Sweden. .; Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, USA. .; Penn Memory Center, Department of Neurology, University of Pennsylvania, Philadelphia, USA. .
de Flores R; Université Normandie, Inserm, Université de Caen-Normandie, Inserm UMR-S U1237, GIP Cyceron, Caen, France.
Xie L; Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, USA.; Penn Memory Center, Department of Neurology, University of Pennsylvania, Philadelphia, USA.
Das SR; Penn Memory Center, Department of Neurology, University of Pennsylvania, Philadelphia, USA.
McMillan CT; Penn FTD Center, Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Trojanowski JQ; Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, USA.
Grossman M; Penn FTD Center, Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Lee EB; Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, USA.
Irwin D; Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, USA.
Yushkevich PA; Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, USA.
Wolk DA; Penn Memory Center, Department of Neurology, University of Pennsylvania, Philadelphia, USA.
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Corporate Authors :
Alzheimer’s Disease NeuroImaging Initiative
Źródło :
Alzheimer's research & therapy [Alzheimers Res Ther] 2021 May 14; Vol. 13 (1), pp. 100. Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*/diagnostic imaging
tau Proteins*/metabolism
Amyloid beta-Peptides/metabolism ; Entorhinal Cortex/metabolism ; Hippocampus/diagnostic imaging ; Hippocampus/metabolism ; Humans ; Magnetic Resonance Imaging ; Temporal Lobe/metabolism
Czasopismo naukowe
Tytuł :
Simultaneous Detection of Six Isoforms of Tau Protein in Human Cerebrospinal Fluid by Multidimensional Mass Spectrometry-Based Targeted Proteomics.
Autorzy :
Xu M; School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Lu M; School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Zhang W; School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Jin Q; Sir Run Run Hospital Affiliated to Nanjing Medical University, Nanjing 211100, China.
Chen Y; School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.; State Key Laboratory of Reproductive Medicine, Nanjing 210029, China.; Key Laboratory of Cardiovascular & Cerebrovascular Medicine, Nanjing 210029, China.
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Źródło :
Journal of proteome research [J Proteome Res] 2021 May 07; Vol. 20 (5), pp. 2299-2307. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*/diagnosis
tau Proteins*
Biomarkers ; Chromatography, Liquid ; Humans ; Mass Spectrometry ; Protein Isoforms ; Proteomics ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Phosphorylation-Induced Structural Reorganization in Tau-Paired Helical Filaments.
Autorzy :
Rani L; Department of Chemistry, Indian Institute of Technology Gandhinagar, Gandhinagar 382355, Gujarat, India.
Mallajosyula SS; Department of Chemistry, Indian Institute of Technology Gandhinagar, Gandhinagar 382355, Gujarat, India.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 May 05; Vol. 12 (9), pp. 1621-1631. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*/metabolism
tau Proteins*/metabolism
Humans ; Neurofibrillary Tangles/metabolism ; Phosphorylation ; Protein Processing, Post-Translational
Czasopismo naukowe
Tytuł :
Size-dependent dynamic stability analysis of the cantilevered curved microtubule-associated proteins (MAPs).
Autorzy :
Zhang P; Huaihe Hospital of Henan University, Kaifeng, China.
Ge Z; School of Basic Medical Sciences, Henan University, Kaifeng, China.
Safarpour M; Department of Mechanical Engineering, Faculty of Engineering, Tarbiat Modares University, Tehran, Iran.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 May; Vol. 39 (8), pp. 2932-2944. Date of Electronic Publication: 2020 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Microtubules*
tau Proteins*
Cytoplasm
Czasopismo naukowe
Tytuł :
Fisetin inhibits tau aggregation by interacting with the protein and preventing the formation of β-strands.
Autorzy :
Xiao S; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, Guangdong 518055, China.
Lu Y; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China.
Wu Q; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China.
Yang J; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China.
Chen J; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China.
Zhong S; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China.
Eliezer D; Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.
Tan Q; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China. Electronic address: .
Wu C; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 May 01; Vol. 178, pp. 381-393. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article
MeSH Terms :
Flavonols/*chemistry
Protein Aggregates/*drug effects
tau Proteins/*chemistry
Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amino Acid Motifs ; Flavonols/pharmacology ; Humans ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Tau internalization: A complex step in tau propagation.
Autorzy :
Zhao J; Institute of Neuroscience, Hengyang Medical College, University of South China, Hengyang, PR China.
Wu H; Institute of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang, PR China.
Tang XQ; Institute of Neuroscience, Hengyang Medical College, University of South China, Hengyang, PR China. Electronic address: .
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Źródło :
Ageing research reviews [Ageing Res Rev] 2021 May; Vol. 67, pp. 101272. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Tauopathies*
tau Proteins*/metabolism
Brain/metabolism ; Endocytosis ; Humans
Czasopismo naukowe
Tytuł :
Phosphorylation in two discrete tau domains regulates a stepwise process leading to postsynaptic dysfunction.
Autorzy :
Teravskis PJ; Department of Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA.; School of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA.
Oxnard BR; College of Biological Sciences, University of Minnesota, Minneapolis, MN, 55455, USA.
Miller EC; Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA.
Kemper L; Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA.
Ashe KH; Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA.; N. Bud Grossman Center for Memory Research and Care, Minneapolis, MN, 55455, USA.; GRECC, Minneapolis VA Medical Center, Minneapolis, MN, 55417, USA.
Liao D; Department of Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA.
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Źródło :
The Journal of physiology [J Physiol] 2021 May; Vol. 599 (9), pp. 2483-2498. Date of Electronic Publication: 2019 Jul 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease*
tau Proteins*
Animals ; Cells, Cultured ; Neurons/metabolism ; Phosphorylation ; Rats
Czasopismo naukowe
Tytuł :
A theoretical study of polymorphism in VQIVYK fibrils.
Autorzy :
Yang J; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio.
Agnihotri MV; Interdisciplinary Biophysics Graduate Program, The Ohio State University, Columbus, Ohio.
Huseby CJ; Interdisciplinary Biophysics Graduate Program, The Ohio State University, Columbus, Ohio.
Kuret J; Interdisciplinary Biophysics Graduate Program, The Ohio State University, Columbus, Ohio; Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, Ohio. Electronic address: .
Singer SJ; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio; Interdisciplinary Biophysics Graduate Program, The Ohio State University, Columbus, Ohio. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2021 Apr 20; Vol. 120 (8), pp. 1396-1416. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Amyloid*
tau Proteins*/genetics
tau Proteins*/metabolism
Cryoelectron Microscopy ; Humans ; Hydrophobic and Hydrophilic Interactions ; Models, Theoretical ; Protein Conformation, beta-Strand
Czasopismo naukowe

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