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Tytuł :
Mechanisms that ensure speed and fidelity in eukaryotic translation termination.
Autorzy :
Lawson MR; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Lessen LN; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.; Program in Molecular Biophysics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wang J; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Prabhakar A; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Corsepius NC; Program in Molecular Biophysics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Green R; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. .; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Puglisi JD; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2021 Aug 20; Vol. 373 (6557), pp. 876-882.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptide Chain Termination, Translational*
Peptide Termination Factors/*metabolism
Ribosomes/*metabolism
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*metabolism
Codon, Terminator ; Fluorescence Resonance Energy Transfer ; Protein Binding ; Protein Biosynthesis ; Saccharomyces cerevisiae/metabolism ; Single Molecule Imaging
Czasopismo naukowe
Tytuł :
Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Autorzy :
Powers KT; University of Bristol, School of Biochemistry, University Walk, Bristol BS8 1TD, UK.
Stevenson-Jones F; University of Bristol, School of Biochemistry, University Walk, Bristol BS8 1TD, UK.
Yadav SKN; University of Bristol, School of Biochemistry, University Walk, Bristol BS8 1TD, UK.
Amthor B; Department of Pediatric Oncology, Hematology and Immunology, Hopp Children's Cancer Research Center Heidelberg (KiTZ), University of Heidelberg, Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU) European Molecular Biology Laboratory (EMBL) and University of Heidelberg, Heidelberg, Germany.
Bufton JC; University of Bristol, School of Biochemistry, University Walk, Bristol BS8 1TD, UK.
Borucu U; University of Bristol, School of Biochemistry, University Walk, Bristol BS8 1TD, UK.
Shen D; University of Bristol, School of Biochemistry, University Walk, Bristol BS8 1TD, UK.
Becker JP; Department of Pediatric Oncology, Hematology and Immunology, Hopp Children's Cancer Research Center Heidelberg (KiTZ), University of Heidelberg, Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU) European Molecular Biology Laboratory (EMBL) and University of Heidelberg, Heidelberg, Germany.
Lavysh D; Department of Pediatric Oncology, Hematology and Immunology, Hopp Children's Cancer Research Center Heidelberg (KiTZ), University of Heidelberg, Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU) European Molecular Biology Laboratory (EMBL) and University of Heidelberg, Heidelberg, Germany.
Hentze MW; Molecular Medicine Partnership Unit (MMPU) European Molecular Biology Laboratory (EMBL) and University of Heidelberg, Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Kulozik AE; Department of Pediatric Oncology, Hematology and Immunology, Hopp Children's Cancer Research Center Heidelberg (KiTZ), University of Heidelberg, Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU) European Molecular Biology Laboratory (EMBL) and University of Heidelberg, Heidelberg, Germany.
Neu-Yilik G; Department of Pediatric Oncology, Hematology and Immunology, Hopp Children's Cancer Research Center Heidelberg (KiTZ), University of Heidelberg, Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU) European Molecular Biology Laboratory (EMBL) and University of Heidelberg, Heidelberg, Germany.
Schaffitzel C; University of Bristol, School of Biochemistry, University Walk, Bristol BS8 1TD, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 21; Vol. 49 (13), pp. 7665-7679.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptide Chain Elongation, Translational/*drug effects
Peptide Chain Termination, Translational/*drug effects
Protein Synthesis Inhibitors/*pharmacology
Cryoelectron Microscopy ; HeLa Cells ; Humans ; Nonsense Mediated mRNA Decay/drug effects ; Nucleosides/chemistry ; Nucleosides/pharmacology ; Peptide Termination Factors/metabolism ; Peptides/metabolism ; Protein Synthesis Inhibitors/chemistry ; RNA, Messenger/metabolism ; RNA, Transfer/chemistry ; RNA, Transfer/metabolism ; Ribosome Subunits, Large, Eukaryotic/chemistry ; Ribosome Subunits, Large, Eukaryotic/drug effects ; Ribosome Subunits, Large, Eukaryotic/metabolism ; Ribosomes/metabolism
Czasopismo naukowe
Tytuł :
Structural basis of translation termination, rescue, and recycling in mammalian mitochondria.
Autorzy :
Kummer E; Swiss Federal Institute of Technology, Institute of Molecular Biology and Biophysics, Otto-Stern-Weg 5, 8093 Zurich, Switzerland. Electronic address: .
Schubert KN; Swiss Federal Institute of Technology, Institute of Molecular Biology and Biophysics, Otto-Stern-Weg 5, 8093 Zurich, Switzerland.
Schoenhut T; Swiss Federal Institute of Technology, Institute of Molecular Biology and Biophysics, Otto-Stern-Weg 5, 8093 Zurich, Switzerland.
Scaiola A; Swiss Federal Institute of Technology, Institute of Molecular Biology and Biophysics, Otto-Stern-Weg 5, 8093 Zurich, Switzerland.
Ban N; Swiss Federal Institute of Technology, Institute of Molecular Biology and Biophysics, Otto-Stern-Weg 5, 8093 Zurich, Switzerland. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Jun 17; Vol. 81 (12), pp. 2566-2582.e6. Date of Electronic Publication: 2021 Apr 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitochondria/*physiology
Mitochondrial Ribosomes/*metabolism
Peptide Chain Termination, Translational/*physiology
Animals ; Carboxylic Ester Hydrolases ; Codon, Terminator ; Cryoelectron Microscopy/methods ; Humans ; Mitochondria/metabolism ; Mitochondrial Proteins/metabolism ; Peptide Chain Termination, Translational/genetics ; Peptide Elongation Factor G/metabolism ; Peptide Termination Factors/metabolism ; Protein Biosynthesis ; Ribosomal Proteins/metabolism ; Ribosomal Proteins/physiology ; Ribosomes/metabolism
Czasopismo naukowe
Tytuł :
Molecular determinants of release factor 2 for ArfA-mediated ribosome rescue.
Autorzy :
Kurita D; Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki, Japan. Electronic address: .
Abo T; Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan.
Himeno H; Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki, Japan. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Sep 18; Vol. 295 (38), pp. 13326-13337. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptide Chain Termination, Translational*
Escherichia coli/*metabolism
Escherichia coli Proteins/*metabolism
Peptide Termination Factors/*metabolism
RNA-Binding Proteins/*metabolism
Ribosomes/*metabolism
Escherichia coli/genetics ; Escherichia coli Proteins/genetics ; Peptide Termination Factors/genetics ; RNA-Binding Proteins/genetics ; Ribosomes/genetics
Czasopismo naukowe
Tytuł :
Alterations in the ribosomal protein bL12 of E. coli affecting the initiation, elongation and termination of protein synthesis.
Autorzy :
Younkin AD; School of Biological and Chemical Sciences, University of Missouri-Kansas City, Kansas City, MO, USA.
Gregory ST; Department of Cell and Molecular Biology, The University of Rhode Island, Kingston, RI, 02881, USA.
O'Connor M; School of Biological and Chemical Sciences, University of Missouri-Kansas City, Kansas City, MO, USA. Electronic address: .
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Źródło :
Biochimie [Biochimie] 2020 Aug; Vol. 175, pp. 173-180. Date of Electronic Publication: 2020 Jun 20.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation*
Peptide Chain Elongation, Translational*
Peptide Chain Initiation, Translational*
Peptide Chain Termination, Translational*
Escherichia coli/*metabolism
Escherichia coli Proteins/*metabolism
Ribosomal Proteins/*metabolism
Codon, Terminator/metabolism ; Escherichia coli/genetics ; Escherichia coli Proteins/genetics ; Peptide Termination Factors/genetics ; Peptide Termination Factors/metabolism ; Protein Domains ; Ribosomal Proteins/genetics
Czasopismo naukowe
Tytuł :
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion.
Autorzy :
Sharma J; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.; Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.; Department of Microbiology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Du M; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Wong E; CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA, USA.
Mutyam V; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.; Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Li Y; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.; Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Chen J; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.; Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Wangen J; Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Thrasher K; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Fu L; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Peng N; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.; Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Tang L; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.; Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Liu K; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Mathew B; Southern Research, Birmingham, AL, USA.
Bostwick RJ; Southern Research, Birmingham, AL, USA.
Augelli-Szafran CE; Southern Research, Birmingham, AL, USA.
Bihler H; CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA, USA.
Liang F; CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA, USA.
Mahiou J; CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA, USA.
Saltz J; CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA, USA.
Rab A; Department of Pediatrics, Emory University, Atlanta, Georgia.
Hong J; Department of Pediatrics, Emory University, Atlanta, Georgia.
Sorscher EJ; Department of Pediatrics, Emory University, Atlanta, Georgia.
Mendenhall EM; Department of Biological Sciences, The University of Alabama in Huntsville, Huntsville, AL, USA.
Coppola CJ; Department of Biological Sciences, The University of Alabama in Huntsville, Huntsville, AL, USA.
Keeling KM; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Green R; Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mense M; CFFT Lab, Cystic Fibrosis Foundation, Lexington, MA, USA.
Suto MJ; Southern Research, Birmingham, AL, USA.
Rowe SM; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.; Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.; Department of Pediatrics, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Bedwell DM; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham (UAB), Birmingham, AL, USA. .; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham (UAB), Birmingham, AL, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 16; Vol. 12 (1), pp. 4358. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Nonsense Mediated mRNA Decay*
Codon, Nonsense/*antagonists & inhibitors
Cystic Fibrosis Transmembrane Conductance Regulator/*genetics
Epithelial Cells/*drug effects
Peptide Chain Termination, Translational/*drug effects
Peptide Termination Factors/*metabolism
Aminoglycosides/metabolism ; Codon, Nonsense/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Epithelial Cells/metabolism ; Genes, Reporter ; Gentamicins/pharmacology ; HEK293 Cells ; Humans ; Microsomes, Liver/drug effects ; Peptide Termination Factors/genetics ; Proteasome Endopeptidase Complex/drug effects ; Proteasome Endopeptidase Complex/metabolism ; RNA Interference ; Ribosomes/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Rho-dependent transcription termination regulates the toxin-antitoxin modules of cryptic prophages to silence their expression in Escherichia coli.
Autorzy :
Hafeezunnisa M; Laboratory of Transcription, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.; Graduate Studies, Manipal Academy of Higher Education, India.
Chhakchhuak PIR; Laboratory of Transcription, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.; Graduate Studies, DBT-Regional Centre for Biotechnology, Faridabad, India.
Krishnakumar J; Laboratory of Transcription, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.
Sen R; Laboratory of Transcription, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.
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Źródło :
FEBS letters [FEBS Lett] 2021 Aug; Vol. 595 (15), pp. 2057-2067. Date of Electronic Publication: 2021 Jun 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Silencing*
Transcription Termination, Genetic*
Escherichia coli/*genetics
Escherichia coli Proteins/*metabolism
Prophages/*genetics
Toxin-Antitoxin Systems/*genetics
Escherichia coli/immunology ; Immunity, Innate ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Ribosome-associated quality control mediates degradation of the premature translation termination product Orf1p of ODC antizyme mRNA.
Autorzy :
Pradhan AK; CSIR-Centre for Cellular and Molecular Biology, Habsiguda, India.
Kandasamy G; CSIR-Centre for Cellular and Molecular Biology, Habsiguda, India.
Chatterjee U; CSIR-Centre for Cellular and Molecular Biology, Habsiguda, India.
Bharadwaj A; Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, India.
Mathew SJ; Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, India.
Dohmen RJ; Institute for Genetics, Faculty of Mathematics and Natural Sciences, Center of Molecular Biosciences, University of Cologne, Germany.
Palanimurugan R; CSIR-Centre for Cellular and Molecular Biology, Habsiguda, India.
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Źródło :
FEBS letters [FEBS Lett] 2021 Aug; Vol. 595 (15), pp. 2015-2033. Date of Electronic Publication: 2021 Jun 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptide Chain Termination, Translational*
Proteins/*genetics
Ribosomes/*metabolism
Animals ; Codon, Terminator ; Mice ; Open Reading Frames ; Quality Control ; Saccharomyces cerevisiae/genetics
Czasopismo naukowe
Tytuł :
The catalytic activity of the translation termination factor methyltransferase Mtq2-Trm112 complex is required for large ribosomal subunit biogenesis.
Autorzy :
Lacoux C; UMR8261 (CNRS, Université de Paris), Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France.
Wacheul L; RNA Molecular Biology, Fonds de la Recherche Scientifique (F.R.S.-FNRS), Université Libre de Bruxelles Cancer Research Center (U-CRC), Center for Microscopy and Molecular Imaging (CMMI), Gosselies, Belgium.
Saraf K; RNA Molecular Biology, Fonds de la Recherche Scientifique (F.R.S.-FNRS), Université Libre de Bruxelles Cancer Research Center (U-CRC), Center for Microscopy and Molecular Imaging (CMMI), Gosselies, Belgium.
Pythoud N; Laboratoire de Spectrométrie de Masse Bio-Organique (LSMBO), UMR 7178, IPHC, Université de Strasbourg, CNRS, Strasbourg, France.
Huvelle E; UMR8261 (CNRS, Université de Paris), Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France.
Figaro S; UMR8261 (CNRS, Université de Paris), Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France.
Graille M; Laboratoire de Biologie Structurale de la Cellule (BIOC), CNRS, Ecole polytechnique, Institut Polytechnique de Paris, F-91128 Palaiseau, France.
Carapito C; Laboratoire de Spectrométrie de Masse Bio-Organique (LSMBO), UMR 7178, IPHC, Université de Strasbourg, CNRS, Strasbourg, France.
Lafontaine DLJ; RNA Molecular Biology, Fonds de la Recherche Scientifique (F.R.S.-FNRS), Université Libre de Bruxelles Cancer Research Center (U-CRC), Center for Microscopy and Molecular Imaging (CMMI), Gosselies, Belgium.
Heurgué-Hamard V; UMR8261 (CNRS, Université de Paris), Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Dec 02; Vol. 48 (21), pp. 12310-12325.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Fungal*
Organelle Biogenesis*
Methyltransferases/*genetics
Peptide Termination Factors/*genetics
Ribosome Subunits, Large, Eukaryotic/*genetics
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
tRNA Methyltransferases/*genetics
Binding Sites ; Biocatalysis ; Cloning, Molecular ; Crystallography, X-Ray ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Methyltransferases/chemistry ; Methyltransferases/metabolism ; Models, Molecular ; Peptide Chain Termination, Translational ; Peptide Termination Factors/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; RNA, Ribosomal/biosynthesis ; RNA, Ribosomal/genetics ; RNA, Ribosomal, 5.8S/biosynthesis ; RNA, Ribosomal, 5.8S/genetics ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Ribosome Subunits, Large, Eukaryotic/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/metabolism ; Substrate Specificity ; tRNA Methyltransferases/chemistry ; tRNA Methyltransferases/metabolism
Czasopismo naukowe
Tytuł :
Termi-Luc: a versatile assay to monitor full-protein release from ribosomes.
Autorzy :
Susorov D; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Egri S; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Korostelev AA; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2020 Dec; Vol. 26 (12), pp. 2044-2050. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Protein Biosynthesis*
Biological Assay/*methods
Luciferases/*metabolism
Peptide Termination Factors/*metabolism
Ribosomes/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Humans ; Peptide Chain Termination, Translational
Czasopismo naukowe
Tytuł :
RNA Sequence and Structure Determinants of Pol III Transcriptional Termination in Human Cells.
Autorzy :
Verosloff MS; Interdisciplinary Biological Sciences Graduate Program, Northwestern University, 2204 Tech Drive, Evanston, IL 60208, USA; Center for Synthetic Biology, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA.
Corcoran WK; Interdisciplinary Biological Sciences Graduate Program, Northwestern University, 2204 Tech Drive, Evanston, IL 60208, USA; Center for Synthetic Biology, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA.
Dolberg TB; Center for Synthetic Biology, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA; Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA.
Bushhouse DZ; Interdisciplinary Biological Sciences Graduate Program, Northwestern University, 2204 Tech Drive, Evanston, IL 60208, USA; Center for Synthetic Biology, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA.
Leonard JN; Center for Synthetic Biology, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA; Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA. Electronic address: .
Lucks JB; Center for Synthetic Biology, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA; Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Jun 25; Vol. 433 (13), pp. 166978. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Transcription Termination, Genetic*
RNA/*genetics
RNA/*metabolism
RNA Polymerase III/*metabolism
Base Sequence ; HEK293 Cells ; Humans ; Nucleic Acid Conformation ; Poly U/genetics ; Promoter Regions, Genetic/genetics ; RNA/chemistry
Czasopismo naukowe
Tytuł :
NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA.
Autorzy :
Mandell ZF; Department of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, United States.
Oshiro RT; Department of Biology, Indiana University, Bloomington, United States.
Yakhnin AV; NCI RNA Biology Laboratory, Center for Cancer Research, NCI, Frederick, United States.
Vishwakarma R; Department of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, United States.
Kashlev M; NCI RNA Biology Laboratory, Center for Cancer Research, NCI, Frederick, United States.
Kearns DB; Department of Biology, Indiana University, Bloomington, United States.
Babitzke P; Department of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, United States.
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Źródło :
ELife [Elife] 2021 Apr 09; Vol. 10. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms :
Gene Expression*
Transcription Termination, Genetic*
Bacillus subtilis/*physiology
Bacterial Proteins/*genetics
Transcriptional Elongation Factors/*genetics
Bacillus subtilis/genetics ; Bacterial Proteins/metabolism ; Base Sequence ; Transcriptional Elongation Factors/metabolism
Czasopismo naukowe
Tytuł :
Extensive ribosome and RF2 rearrangements during translation termination.
Autorzy :
Svidritskiy E; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, United States.
Demo G; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, United States.
Loveland AB; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, United States.
Xu C; Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, United States.
Korostelev AA; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, United States.; Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, United States.
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Źródło :
ELife [Elife] 2019 Sep 12; Vol. 8. Date of Electronic Publication: 2019 Sep 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Peptide Chain Termination, Translational*
Escherichia coli/*metabolism
Escherichia coli Proteins/*metabolism
Peptide Termination Factors/*metabolism
Ribosomes/*metabolism
Cryoelectron Microscopy ; Escherichia coli Proteins/chemistry ; Peptide Termination Factors/chemistry ; Ribosomes/chemistry
Czasopismo naukowe
Tytuł :
The Origin and Evolution of Release Factors: Implications for Translation Termination, Ribosome Rescue, and Quality Control Pathways.
Autorzy :
Burroughs AM; Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. .
Aravind L; Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Apr 23; Vol. 20 (8). Date of Electronic Publication: 2019 Apr 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Peptide Chain Termination, Translational*
Carboxylic Ester Hydrolases/*genetics
Peptide Termination Factors/*genetics
Ribosomes/*genetics
Amino Acid Sequence ; Animals ; Carboxylic Ester Hydrolases/chemistry ; Carboxylic Ester Hydrolases/metabolism ; Evolution, Molecular ; Humans ; Models, Molecular ; Peptide Termination Factors/chemistry ; Peptide Termination Factors/metabolism ; Phylogeny ; Protein Biosynthesis ; Protein Domains ; Ribosomes/metabolism
Czasopismo naukowe
Tytuł :
Early completion of phase I cancer clinical trials with Bayesian optimal interval design.
Autorzy :
Kojima M; Biometrics Department, R&D Division, Kyowa Kirin Co., Ltd., Tokyo, Japan.; Department of Statistical Science, School of Multidisciplinary Sciences, The Graduate University for Advanced Studies, Tokyo, Japan.
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Źródło :
Statistics in medicine [Stat Med] 2021 Jun 30; Vol. 40 (14), pp. 3215-3226. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
Early Termination of Clinical Trials*
Models, Statistical*
Neoplasms*/therapy
Bayes Theorem ; Clinical Trials, Phase I as Topic ; Computer Simulation ; Dose-Response Relationship, Drug ; Humans
Czasopismo naukowe
Tytuł :
Luciferase-based reporter system for in vitro evaluation of elongation rate and processivity of ribosomes.
Autorzy :
Kisly I; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.
Kattel C; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.
Remme J; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.
Tamm T; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jun 04; Vol. 49 (10), pp. e59.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptide Chain Elongation, Translational*
Peptide Chain Termination, Translational*
Luciferases, Firefly/*metabolism
RNA, Messenger/*metabolism
Ribosomes/*metabolism
Genes, Reporter ; Saccharomyces cerevisiae
Czasopismo naukowe
Tytuł :
CTELS: A Cell-Free System for the Analysis of Translation Termination Rate.
Autorzy :
Lashkevich KA; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.
Shlyk VI; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.; Department of Molecular Biology, Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia.
Kushchenko AS; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.; School of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119234 Moscow, Russia.
Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Alkalaeva EZ; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Dmitriev SE; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.; School of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119234 Moscow, Russia.; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
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Źródło :
Biomolecules [Biomolecules] 2020 Jun 16; Vol. 10 (6). Date of Electronic Publication: 2020 Jun 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Codon, Nonsense*
Mutation Rate*
Biological Assay/*methods
Peptide Chain Termination, Translational/*genetics
Cell-Free System/physiology ; Codon, Terminator/genetics ; DNA Mutational Analysis ; Genes, Reporter ; Humans ; In Vitro Techniques ; Luciferases/genetics ; Luciferases/metabolism ; Peptide Chain Termination, Translational/physiology ; Peptide Termination Factors/genetics ; Peptide Termination Factors/metabolism ; Protein Biosynthesis/genetics
Czasopismo naukowe
Tytuł :
Polyadenylate-binding protein-interacting proteins PAIP1 and PAIP2 affect translation termination.
Autorzy :
Ivanov A; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia; Faculty of Bioengineering and Bioinformatics, M. V. Lomonosov Moscow State University, Moscow 119234, Russia.
Shuvalova E; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia.
Egorova T; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia.
Shuvalov A; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia.
Sokolova E; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia.
Bizyaev N; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia.
Shatsky I; Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University, Moscow 119234, Russia.
Terenin I; Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University, Moscow 119234, Russia; Sechenov First Moscow State Medical University, Institute of Molecular Medicine, Moscow 119146, Russia. Electronic address: .
Alkalaeva E; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 May 24; Vol. 294 (21), pp. 8630-8639. Date of Electronic Publication: 2019 Apr 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptide Chain Termination, Translational*
Peptide Initiation Factors/*metabolism
Peptide Termination Factors/*metabolism
RNA, Messenger/*metabolism
RNA-Binding Proteins/*metabolism
Repressor Proteins/*metabolism
Humans ; Peptide Initiation Factors/chemistry ; Peptide Termination Factors/chemistry ; Poly A/chemistry ; Poly A/metabolism ; RNA, Messenger/chemistry ; RNA-Binding Proteins/chemistry ; Repressor Proteins/chemistry
Czasopismo naukowe
Tytuł :
Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity.
Autorzy :
Ortega JA; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Daley EL; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Kour S; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
Samani M; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Tellez L; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Smith HS; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Hall EA; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Esengul YT; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Tsai YH; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Gendron TF; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Donnelly CJ; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA; LiveLikeLou Center for ALS Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
Siddique T; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Savas JN; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Pandey UB; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
Kiskinis E; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Apr 08; Vol. 106 (1), pp. 90-107.e13. Date of Electronic Publication: 2020 Feb 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyotrophic Lateral Sclerosis/*genetics
C9orf72 Protein/*genetics
Drosophila Proteins/*genetics
Frontotemporal Dementia/*genetics
Neurons/*metabolism
Nonsense Mediated mRNA Decay/*genetics
Peptide Termination Factors/*genetics
RNA, Messenger/*metabolism
Amyotrophic Lateral Sclerosis/metabolism ; Animals ; C9orf72 Protein/metabolism ; Cell Fractionation ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Frontotemporal Dementia/metabolism ; HEK293 Cells ; Humans ; Induced Pluripotent Stem Cells ; Nuclear Envelope ; Peptide Chain Termination, Translational/genetics ; Peptide Termination Factors/metabolism ; Protein Biosynthesis ; Proteome ; Subcellular Fractions ; Tandem Mass Spectrometry
SCR Disease Name :
Frontotemporal Dementia With Motor Neuron Disease
Czasopismo naukowe

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