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Tytuł:
Molecular basis of translation termination at noncanonical stop codons in human mitochondria.
Autorzy:
Saurer M; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland.
Leibundgut M; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland.
Nadimpalli HP; Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland.
Scaiola A; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland.
Schönhut T; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland.
Lee RG; Harry Perkins Institute of Medical Research, The University of Western Australia, Nedlands, Western Australia 6009, Australia.; ARC Centre of Excellence in Synthetic Biology, QEII Medical Centre, The University of Western Australia, Nedlands, Western Australia 6009, Australia.; Telethon Kids Institute, Northern Entrance, Perth Children's Hospital, 15 Hospital Avenue, Nedlands, Western Australia, Australia.
Siira SJ; Harry Perkins Institute of Medical Research, The University of Western Australia, Nedlands, Western Australia 6009, Australia.; ARC Centre of Excellence in Synthetic Biology, QEII Medical Centre, The University of Western Australia, Nedlands, Western Australia 6009, Australia.
Rackham O; Harry Perkins Institute of Medical Research, The University of Western Australia, Nedlands, Western Australia 6009, Australia.; ARC Centre of Excellence in Synthetic Biology, QEII Medical Centre, The University of Western Australia, Nedlands, Western Australia 6009, Australia.; Telethon Kids Institute, Northern Entrance, Perth Children's Hospital, 15 Hospital Avenue, Nedlands, Western Australia, Australia.; Curtin Medical School and Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia 6102, Australia.
Dreos R; Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland.
Lenarčič T; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland.
Kummer E; Novo Nordisk Foundation Center for Protein Research, Protein Structure and Function Program, Blegdamsvej 3B, 2200 København N, Denmark.
Gatfield D; Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland.
Filipovska A; Harry Perkins Institute of Medical Research, The University of Western Australia, Nedlands, Western Australia 6009, Australia.; ARC Centre of Excellence in Synthetic Biology, QEII Medical Centre, The University of Western Australia, Nedlands, Western Australia 6009, Australia.; Telethon Kids Institute, Northern Entrance, Perth Children's Hospital, 15 Hospital Avenue, Nedlands, Western Australia, Australia.
Ban N; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland.
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Źródło:
Science (New York, N.Y.) [Science] 2023 May 05; Vol. 380 (6644), pp. 531-536. Date of Electronic Publication: 2023 May 04.
Typ publikacji:
Journal Article
MeSH Terms:
Codon, Terminator*
Mitochondria*/genetics
Mitochondria*/metabolism
Peptide Chain Termination, Translational*
Peptide Termination Factors*/chemistry
Humans ; Cryoelectron Microscopy ; Protein Conformation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sequestrase chaperones protect against oxidative stress-induced protein aggregation and [PSI+] prion formation.
Autorzy:
Carter Z; Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, United Kingdom.
Creamer D; Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, United Kingdom.
Kouvidi A; Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, United Kingdom.
Grant CM; Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, United Kingdom.
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Źródło:
PLoS genetics [PLoS Genet] 2024 Feb 29; Vol. 20 (2), pp. e1011194. Date of Electronic Publication: 2024 Feb 29 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Prions*/genetics
Prions*/metabolism
Saccharomyces cerevisiae Proteins*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
Protein Aggregates/genetics ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Oxidative Stress/genetics ; Amyloid/metabolism ; Oxidants/pharmacology ; Oxidants/metabolism ; Peptide Termination Factors/genetics ; Peptide Termination Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Predictors and outcomes of withholding and withdrawal of life-sustaining treatments in intensive care units in Singapore: a multicentre observational study.
Autorzy:
Fong, Clare (AUTHOR)
Kueh, Wern Lunn (AUTHOR)
Lew, Sennen Jin Wen (AUTHOR)
Ho, Benjamin Choon Heng (AUTHOR)
Wong, Yu-Lin (AUTHOR)
Lau, Yie Hui (AUTHOR)
Chia, Yew Woon (AUTHOR)
Tan, Hui Ling (AUTHOR)
Seet, Ying Hao Christopher (AUTHOR)
Siow, Wen Ting (AUTHOR)
MacLaren, Graeme (AUTHOR)
Agrawal, Rohit (AUTHOR)
Lim, Tian Jin (AUTHOR)
Lim, Shir Lynn (AUTHOR)
Lim, Toon Wei (AUTHOR)
Ho, Vui Kian (AUTHOR)
Soh, Chai Rick (AUTHOR)
Sewa, Duu Wen (AUTHOR)
Loo, Chian Min (AUTHOR)
Khan, Faheem Ahmed (AUTHOR)
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Źródło:
Journal of Intensive Care. 3/26/2024, Vol. 12 Issue 1, p1-10. 10p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mechanisms that ensure speed and fidelity in eukaryotic translation termination.
Autorzy:
Lawson MR; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Lessen LN; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.; Program in Molecular Biophysics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wang J; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Prabhakar A; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Corsepius NC; Program in Molecular Biophysics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Green R; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. .; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Puglisi JD; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2021 Aug 20; Vol. 373 (6557), pp. 876-882.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Peptide Chain Termination, Translational*
Peptide Termination Factors/*metabolism
Ribosomes/*metabolism
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*metabolism
Codon, Terminator ; Fluorescence Resonance Energy Transfer ; Protein Binding ; Protein Biosynthesis ; Saccharomyces cerevisiae/metabolism ; Single Molecule Imaging
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Origin and Evolution of Release Factors: Implications for Translation Termination, Ribosome Rescue, and Quality Control Pathways.
Autorzy:
Burroughs AM; Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. .
Aravind L; Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Apr 23; Vol. 20 (8). Date of Electronic Publication: 2019 Apr 23.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Peptide Chain Termination, Translational*
Carboxylic Ester Hydrolases/*genetics
Peptide Termination Factors/*genetics
Ribosomes/*genetics
Amino Acid Sequence ; Animals ; Carboxylic Ester Hydrolases/chemistry ; Carboxylic Ester Hydrolases/metabolism ; Evolution, Molecular ; Humans ; Models, Molecular ; Peptide Termination Factors/chemistry ; Peptide Termination Factors/metabolism ; Phylogeny ; Protein Biosynthesis ; Protein Domains ; Ribosomes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Discontinuation risk from adverse events: immunotherapy alone vs. combined with chemotherapy: a systematic review and network meta-analysis.
Autorzy:
Shin, Sangwon (AUTHOR)
Moon, Jimin (AUTHOR)
Oum, Chiyoon (AUTHOR)
Kim, Seulki (AUTHOR)
Cho, Soo Ick (AUTHOR)
Lim, Yoojoo (AUTHOR)
Ock, Chan-Young (AUTHOR)
Shin, Seunghwan (AUTHOR)
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Źródło:
BMC Cancer. 1/30/2024, Vol. 24 Issue 1, p1-12. 12p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Navigating the ICI Combination Treatment Journey: Patterns of Response and Progression to First-Line ICI-Based Combination Treatment in Metastatic Renal Cell Carcinoma.
Autorzy:
Samuelly, Alessandro (AUTHOR)
Di Stefano, Rosario Francesco (AUTHOR)
Turco, Fabio (AUTHOR)
Delcuratolo, Marco Donatello (AUTHOR)
Pisano, Chiara (AUTHOR)
Saporita, Isabella (AUTHOR)
Calabrese, Mariangela (AUTHOR)
Carfì, Federica Maria (AUTHOR)
Tucci, Marcello (AUTHOR)
Buttigliero, Consuelo (AUTHOR)
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Źródło:
Journal of Clinical Medicine. Jan2024, Vol. 13 Issue 2, p307. 22p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Alterations in DNA methylation associate with reduced migraine and headache days after medication withdrawal treatment in chronic migraine patients: a longitudinal study.
Autorzy:
Mehta, Divya (AUTHOR)
de Boer, Irene (AUTHOR)
Sutherland, Heidi G. (AUTHOR)
Pijpers, Judith A. (AUTHOR)
Bron, Charlene (AUTHOR)
Bainomugisa, Charlotte (AUTHOR)
Haupt, Larisa M. (AUTHOR)
van den Maagdenberg, Arn M. J. M. (AUTHOR)
Griffiths, Lyn R. (AUTHOR)
Nyholt, Dale R. (AUTHOR)
Terwindt, Gisela M. (AUTHOR)
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Źródło:
Clinical Epigenetics. 12/12/2023, Vol. 15 Issue 1, p1-12. 12p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CTELS: A Cell-Free System for the Analysis of Translation Termination Rate.
Autorzy:
Lashkevich KA; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.
Shlyk VI; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.; Department of Molecular Biology, Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia.
Kushchenko AS; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.; School of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119234 Moscow, Russia.
Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Alkalaeva EZ; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Dmitriev SE; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.; School of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119234 Moscow, Russia.; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
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Źródło:
Biomolecules [Biomolecules] 2020 Jun 16; Vol. 10 (6). Date of Electronic Publication: 2020 Jun 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Codon, Nonsense*
Mutation Rate*
Biological Assay/*methods
Peptide Chain Termination, Translational/*genetics
Cell-Free System/physiology ; Codon, Terminator/genetics ; DNA Mutational Analysis ; Genes, Reporter ; Humans ; In Vitro Techniques ; Luciferases/genetics ; Luciferases/metabolism ; Peptide Chain Termination, Translational/physiology ; Peptide Termination Factors/genetics ; Peptide Termination Factors/metabolism ; Protein Biosynthesis/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Overall survival of patients with hepatocellular carcinoma treated with sintilimab and disease outcome after treatment discontinuation.
Autorzy:
Wang, Kang (AUTHOR)
Xiang, Yan-Jun (AUTHOR)
Yu, Hong-Ming (AUTHOR)
Cheng, Yu-Qiang (AUTHOR)
Feng, Jin-Kai (AUTHOR)
Liu, Zong-Han (AUTHOR)
Shan, Yun-Feng (AUTHOR)
Zheng, Yi-Tao (AUTHOR)
Ni, Qian-Zhi (AUTHOR)
Cheng, Shu-Qun (AUTHOR)
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Źródło:
BMC Cancer. 10/23/2023, Vol. 23 Issue 1, p1-11. 11p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
THeragnostic utilities for neoplastic DisEases of the rectum by MRI guided radiotherapy (THUNDER 2) phase II trial: interim safety analysis.
Autorzy:
Chiloiro, Giuditta (AUTHOR)
Romano, Angela (AUTHOR)
Cusumano, Davide (AUTHOR)
Boldrini, Luca (AUTHOR)
Panza, Giulia (AUTHOR)
Placidi, Lorenzo (AUTHOR)
Meldolesi, Elisa (AUTHOR)
Nardini, Matteo (AUTHOR)
Meffe, Guenda (AUTHOR)
Nicolini, Gianluca (AUTHOR)
Votta, Claudio (AUTHOR)
Indovina, Luca (AUTHOR)
Gambacorta, Maria Antonietta (AUTHOR)
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Źródło:
Radiation Oncology. 10/6/2023, Vol. 18 Issue 1, p1-8. 8p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Nutzung von Anschlussmaßnahmen nach stationärem Alkoholentzug: Annahmen zum Stand der Vernetzung im deutschen Suchthilfesystem.
Autorzy:
Reichl, Daniela (AUTHOR)
Enewoldsen, Niklas (AUTHOR)
Tegethoff, Paulina (AUTHOR)
Gendlina, Taisia (AUTHOR)
Saur, Sebastian (AUTHOR)
Lang, Catharina (AUTHOR)
Fuhrmann, Lukas (AUTHOR)
Weisel, Kiona K. (AUTHOR)
Berking, Matthias (AUTHOR)
Zink, Mathias (AUTHOR)
Ahnert, Andreas (AUTHOR)
Falkai, Peter (AUTHOR)
Kraus, Thomas (AUTHOR)
Hillemacher, Thomas (AUTHOR)
Müller, Felix-Nicolai (AUTHOR)
Kornhuber, Johannes (AUTHOR)
Bönsch, Dominikus (AUTHOR)
Achtert, Katharina (AUTHOR)
Steins-Loeber, Sabine (AUTHOR)
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Alternatywny tytuł:
Use of Aftercare Following Inpatient Alcohol Withdrawal Treatment: Assumptions on the Status of Networking in the German Addiction Treatment System.
Źródło:
Sucht. okt2023, Vol. 69 Issue 5, p243-254. 12p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Occurrence and Risk Factors for Perioperative Treatment Discontinuation during Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU) Therapy in Symptomatic Uterine Fibroids—A Retrospective Case–Control Study.
Autorzy:
Kociuba, Jakub (AUTHOR)
Łoziński, Tomasz (AUTHOR)
Latra, Kamil (AUTHOR)
Korczyńska, Lidia (AUTHOR)
Skowyra, Artur (AUTHOR)
Zarychta, Elżbieta (AUTHOR)
Ciebiera, Michał (AUTHOR)
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Źródło:
Journal of Clinical Medicine. Sep2023, Vol. 12 Issue 18, p5999. 11p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dospělá výška dětí, které se narodily malé na svůj gestační věk (SGA), s malou výškou v dětství (SGA-SS). Výsledky léčby růstovým hormonem z dat české národní databáze REPAR
Autorzy:
Ledjona, Toni (AUTHOR)
Lukáš, Plachý (AUTHOR)
Barbora, Jírová (AUTHOR)
Irena, Hainerová Aldhoon (AUTHOR)
Darina, Aleksijevi (AUTHOR)
Jana, Černá (AUTHOR)
Marcela, Dvořáková (AUTHOR)
Eva, El-Lababidi (AUTHOR)
Božena, Kalvachová (AUTHOR)
Kamila, Kocourková (AUTHOR)
Ivana, Kotvalová (AUTHOR)
Olga, Magnová (AUTHOR)
Dana, Novotná (AUTHOR)
Barbora, Obermannová (AUTHOR)
Renata, Pomahačová (AUTHOR)
Štěpánka, Průhová (AUTHOR)
Ondřej, Souček (AUTHOR)
Jiří, Strnadel (AUTHOR)
Lucie, Šíchová (AUTHOR)
Jaroslav, Škvor (AUTHOR)
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Alternatywny tytuł:
Adult height in children born small for gestational age (SGA) with persistent short stature (SGA-SS). Growth hormone treatment outcomes from data of the Czech countrywide REPAR database.
Źródło:
Czecho-Slovak Pediatrics / Česko-Slovenská Pediatrie. 2023 Supplement 3, Vol. 78, p22-29. 8p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prevalence and prediction of dropout during depression treatment in routine outpatient care: an observational study.
Autorzy:
van Dijk, D. A. (AUTHOR)
Deen, M. L. (AUTHOR)
van den Boogaard, Th. M. (AUTHOR)
Ruhé, H. G. (AUTHOR)
Spijker, J. (AUTHOR)
Peeters, F. P. M. L. (AUTHOR)
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Źródło:
European Archives of Psychiatry & Clinical Neuroscience. Aug2023, Vol. 273 Issue 5, p1151-1161. 11p. 1 Diagram, 2 Charts, 1 Graph.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dbp5/DDX19 between Translational Readthrough and Nonsense Mediated Decay.
Autorzy:
Beißel C; Abteilung für Molekulare Genetik, Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften (GZMB), Georg-August Universität Göttingen, 37077 Göttingen, Germany.
Grosse S; Abteilung für Molekulare Genetik, Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften (GZMB), Georg-August Universität Göttingen, 37077 Göttingen, Germany.
Krebber H; Abteilung für Molekulare Genetik, Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften (GZMB), Georg-August Universität Göttingen, 37077 Göttingen, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Feb 06; Vol. 21 (3). Date of Electronic Publication: 2020 Feb 06.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Codon, Nonsense/*genetics
DEAD-box RNA Helicases/*genetics
Nonsense Mediated mRNA Decay/*genetics
Nucleocytoplasmic Transport Proteins/*genetics
Peptide Chain Termination, Translational/*genetics
Codon, Terminator/genetics ; DEAD-box RNA Helicases/metabolism ; Humans ; Nucleocytoplasmic Transport Proteins/metabolism ; Peptide Termination Factors/metabolism ; Ribosomes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibition of translation termination by small molecules targeting ribosomal release factors.
Autorzy:
Ge X; Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, SE-75124, Uppsala, Sweden.
Oliveira A; Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, SE-75124, Uppsala, Sweden.
Hjort K; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, SE-75124, Uppsala, Sweden.
Bergfors T; Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, SE-75124, Uppsala, Sweden.
Gutiérrez-de-Terán H; Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, SE-75124, Uppsala, Sweden.
Andersson DI; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, SE-75124, Uppsala, Sweden.
Sanyal S; Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, SE-75124, Uppsala, Sweden.
Åqvist J; Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, SE-75124, Uppsala, Sweden. .
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Źródło:
Scientific reports [Sci Rep] 2019 Oct 28; Vol. 9 (1), pp. 15424. Date of Electronic Publication: 2019 Oct 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Escherichia coli/*chemistry
Escherichia coli Proteins/*chemistry
Peptide Termination Factors/*chemistry
Ribosomes/*chemistry
Thermus thermophilus/*chemistry
Anti-Bacterial Agents/chemistry ; Escherichia coli/metabolism ; Escherichia coli Proteins/antagonists & inhibitors ; Escherichia coli Proteins/metabolism ; Peptide Chain Termination, Translational/drug effects ; Peptide Termination Factors/antagonists & inhibitors ; Peptide Termination Factors/metabolism ; Ribosomes/metabolism ; Thermus thermophilus/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Translational termination without a stop codon.
Autorzy:
James NR; Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
Brown A; Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
Gordiyenko Y; Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
Ramakrishnan V; Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK. .
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Źródło:
Science (New York, N.Y.) [Science] 2016 Dec 16; Vol. 354 (6318), pp. 1437-1440. Date of Electronic Publication: 2016 Dec 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Codon, Terminator*
Peptide Chain Termination, Translational*
Escherichia coli/*metabolism
Escherichia coli Proteins/*ultrastructure
Peptide Termination Factors/*chemistry
RNA-Binding Proteins/*ultrastructure
3' Untranslated Regions ; Cryoelectron Microscopy ; Escherichia coli/genetics ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/metabolism ; Peptide Termination Factors/metabolism ; Peptides/chemistry ; Peptides/metabolism ; Protein Conformation ; Protein Stability ; RNA, Bacterial/chemistry ; RNA, Ribosomal/chemistry ; RNA, Ribosomal/metabolism ; RNA-Binding Proteins/chemistry ; RNA-Binding Proteins/metabolism ; Ribosomes/chemistry ; Ribosomes/metabolism ; Ribosomes/ultrastructure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Mammalian HEMK1 methylates glutamine residue of the GGQ motif of mitochondrial release factors.
Autorzy:
Fang Q; Cellular Memory Laboratory, RIKEN Cluster for Pioneering Research, RIKEN, Wako, Saitama, 351-0198, Japan.; Graduate School of Science and Engineering, Saitama University, Saitama, 338-8570, Japan.
Kimura Y; RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, 351-0198, Japan.; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, 277-8561, Japan.
Shimazu T; Cellular Memory Laboratory, RIKEN Cluster for Pioneering Research, RIKEN, Wako, Saitama, 351-0198, Japan.
Suzuki T; Biomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science, Wako, Saitama, 351-0198, Japan.
Yamada A; Cellular Memory Laboratory, RIKEN Cluster for Pioneering Research, RIKEN, Wako, Saitama, 351-0198, Japan.
Dohmae N; Biomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science, Wako, Saitama, 351-0198, Japan.
Iwasaki S; RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, 351-0198, Japan.; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, 277-8561, Japan.
Shinkai Y; Cellular Memory Laboratory, RIKEN Cluster for Pioneering Research, RIKEN, Wako, Saitama, 351-0198, Japan. .; Graduate School of Science and Engineering, Saitama University, Saitama, 338-8570, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2022 Mar 08; Vol. 12 (1), pp. 4104. Date of Electronic Publication: 2022 Mar 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Glutamine*/metabolism
Peptide Termination Factors*/metabolism
Animals ; Humans ; Amino Acid Motifs ; HeLa Cells ; Mammals/metabolism ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Regulation of Heterogenous LexA Expression in Staphylococcus aureus by an Antisense RNA Originating from Transcriptional Read-Through upon Natural Mispairings in the sbrB Intrinsic Terminator.
Autorzy:
Bastet L; Instituto de Agrobiotecnología (IdAB), Consejo Superior de Investigaciones Científicas (CSIC)-Gobierno de Navarra, Avda. de Pamplona 123, 31192 Mutilva, Spain.
Bustos-Sanmamed P; Instituto de Agrobiotecnología (IdAB), Consejo Superior de Investigaciones Científicas (CSIC)-Gobierno de Navarra, Avda. de Pamplona 123, 31192 Mutilva, Spain.
Catalan-Moreno A; Instituto de Agrobiotecnología (IdAB), Consejo Superior de Investigaciones Científicas (CSIC)-Gobierno de Navarra, Avda. de Pamplona 123, 31192 Mutilva, Spain.
Caballero CJ; Instituto de Agrobiotecnología (IdAB), Consejo Superior de Investigaciones Científicas (CSIC)-Gobierno de Navarra, Avda. de Pamplona 123, 31192 Mutilva, Spain.
Cuesta S; Instituto de Agrobiotecnología (IdAB), Consejo Superior de Investigaciones Científicas (CSIC)-Gobierno de Navarra, Avda. de Pamplona 123, 31192 Mutilva, Spain.
Matilla-Cuenca L; Instituto de Agrobiotecnología (IdAB), Consejo Superior de Investigaciones Científicas (CSIC)-Gobierno de Navarra, Avda. de Pamplona 123, 31192 Mutilva, Spain.
Villanueva M; Instituto de Agrobiotecnología (IdAB), Consejo Superior de Investigaciones Científicas (CSIC)-Gobierno de Navarra, Avda. de Pamplona 123, 31192 Mutilva, Spain.
Valle J; Instituto de Agrobiotecnología (IdAB), Consejo Superior de Investigaciones Científicas (CSIC)-Gobierno de Navarra, Avda. de Pamplona 123, 31192 Mutilva, Spain.
Lasa I; Laboratory of Microbial Pathogenesis, Navarrabiomed-Universidad Pública de Navarra (UPNA)-Hospital Universitario de Navarra-IdiSNA, 31008 Pamplona, Spain.
Toledo-Arana A; Instituto de Agrobiotecnología (IdAB), Consejo Superior de Investigaciones Científicas (CSIC)-Gobierno de Navarra, Avda. de Pamplona 123, 31192 Mutilva, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 05; Vol. 23 (1). Date of Electronic Publication: 2022 Jan 05.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Bacterial*
Transcription Termination, Genetic*
Transcription, Genetic*
Bacterial Proteins/*genetics
RNA, Antisense/*genetics
Serine Endopeptidases/*genetics
Staphylococcus aureus/*genetics
Bacterial Proteins/metabolism ; Base Sequence ; Genes, Reporter ; Nucleic Acid Conformation ; Point Mutation ; Protein Processing, Post-Translational ; RNA, Antisense/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Resumption of Spermatogenesis and Fertility Post Withdrawal of Hydroxyurea Treatment.
Autorzy:
Virgous, Carlos (AUTHOR)
Lyons, Letitia (AUTHOR)
Sakwe, Amos (AUTHOR)
Nayyar, Tultul (AUTHOR)
Goodwin, Shawn (AUTHOR)
Hildreth, James (AUTHOR)
Osteen, Kevin (AUTHOR)
Bruner-Tran, Kaylon (AUTHOR)
Alawode, Oluwatobi (AUTHOR)
Bourne, Phillip (AUTHOR)
Hills, Edward Richard (AUTHOR)
Archibong, Anthony E. (AUTHOR)
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Źródło:
International Journal of Molecular Sciences. Jun2023, Vol. 24 Issue 11, p9374. 17p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Efficacy and Durability of Dolutegravir- or Darunavir-Based Regimens in ART-Naïve AIDS- or Late-Presenting HIV-Infected Patients.
Autorzy:
Fabbiani, Massimiliano (AUTHOR)
Masini, Melissa (AUTHOR)
Rossetti, Barbara (AUTHOR)
Ciccullo, Arturo (AUTHOR)
Borghi, Vanni (AUTHOR)
Lagi, Filippo (AUTHOR)
Capetti, Amedeo (AUTHOR)
Colafigli, Manuela (AUTHOR)
Panza, Francesca (AUTHOR)
Baldin, Gianmaria (AUTHOR)
Mussini, Cristina (AUTHOR)
Sterrantino, Gaetana (AUTHOR)
Farinacci, Damiano (AUTHOR)
Montagnani, Francesca (AUTHOR)
Tumbarello, Mario (AUTHOR)
Di Giambenedetto, Simona (AUTHOR)
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Źródło:
Viruses (1999-4915). May2023, Vol. 15 Issue 5, p1123. 13p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Analysis of SINE Families B2, Dip, and Ves with Special Reference to Polyadenylation Signals and Transcription Terminators.
Autorzy:
Vassetzky NS; Laboratory of Eukaryotic Genome Evolution, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Borodulina OR; Laboratory of Eukaryotic Genome Evolution, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Ustyantsev IG; Laboratory of Eukaryotic Genome Evolution, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Kosushkin SA; Laboratory of Eukaryotic Genome Evolution, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Kramerov DA; Laboratory of Eukaryotic Genome Evolution, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 13; Vol. 22 (18). Date of Electronic Publication: 2021 Sep 13.
Typ publikacji:
Journal Article
MeSH Terms:
Evolution, Molecular*
Transcription Termination, Genetic*
Retroelements/*genetics
Short Interspersed Nucleotide Elements/*genetics
Animals ; Humans ; Mice ; Poly A/genetics ; Polyadenylation/genetics ; RNA/genetics ; RNA 3' Polyadenylation Signals/genetics ; RNA Polymerase III/genetics ; RNA, Messenger/genetics ; Transcription, Genetic/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Yeast Chaperone Hsp70-Ssb Modulates a Variety of Protein-Based Heritable Elements.
Autorzy:
Jay-Garcia LM; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Cornell JL; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Howie RL; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Faber QL; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Salas A; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Chernova TA; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
Chernoff YO; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 12; Vol. 24 (10). Date of Electronic Publication: 2023 May 12.
Typ publikacji:
Journal Article
MeSH Terms:
Saccharomyces cerevisiae Proteins*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
Prions*/metabolism
GTP-Binding Protein gamma Subunits*/metabolism
Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Molecular Chaperones/metabolism ; HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/metabolism ; Glutathione Peroxidase/metabolism ; Peptide Termination Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hopping and Flipping of RNA Polymerase on DNA during Recycling for Reinitiation after Intrinsic Termination in Bacterial Transcription.
Autorzy:
Kang W; Department of Physics and Astronomy, and Institute of Applied Physics, Seoul National University, Seoul 08826, Korea.
Hwang S; Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Kang JY; Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Kang C; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Hohng S; Department of Physics and Astronomy, and Institute of Applied Physics, Seoul National University, Seoul 08826, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 27; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 27.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Bacterial*
Transcription Initiation, Genetic*
Transcription Termination, Genetic*
DNA, Bacterial/*metabolism
DNA-Directed RNA Polymerases/*metabolism
Escherichia coli/*genetics
Escherichia coli Proteins/*metabolism
DNA, Bacterial/genetics ; DNA-Directed RNA Polymerases/genetics ; Escherichia coli/growth & development ; Escherichia coli/metabolism ; Escherichia coli Proteins/genetics ; Promoter Regions, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Ribosome-bound Pub1 modulates stop codon decoding during translation termination in yeast.
Autorzy:
Urakov VN; Federal Research Center 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Bach Institute of Biochemistry, Moscow, Russia.
Mitkevich OV; Federal Research Center 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Bach Institute of Biochemistry, Moscow, Russia.
Safenkova IV; Federal Research Center 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Bach Institute of Biochemistry, Moscow, Russia.
Ter-Avanesyan MD; Federal Research Center 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Bach Institute of Biochemistry, Moscow, Russia.
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Źródło:
The FEBS journal [FEBS J] 2017 Jun; Vol. 284 (12), pp. 1914-1930. Date of Electronic Publication: 2017 May 29.
Typ publikacji:
Journal Article
MeSH Terms:
Peptide Termination Factors/*metabolism
Poly(A)-Binding Proteins/*metabolism
Ribosomes/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Codon, Terminator ; Peptide Chain Termination, Translational ; Peptide Termination Factors/genetics ; Poly(A)-Binding Proteins/genetics ; Ribosomes/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/growth & development ; Saccharomyces cerevisiae Proteins/genetics ; Sequence Deletion
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Emerging Personalized Opportunities for Enhancing Translational Readthrough in Rare Genetic Diseases and Beyond.
Autorzy:
Wagner RN; Department of Dermatology and Allergology, University Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria.
Wießner M; Department of Dermatology and Allergology, University Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria.
Friedrich A; Department of Dermatology and Allergology, University Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria.; Department of Biosciences, University of Salzburg, 5020 Salzburg, Austria.
Zandanell J; Department of Dermatology and Allergology, University Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria.
Breitenbach-Koller H; Department of Biosciences, University of Salzburg, 5020 Salzburg, Austria.
Bauer JW; Department of Dermatology and Allergology, University Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 23; Vol. 24 (7). Date of Electronic Publication: 2023 Mar 23.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Codon, Nonsense*/genetics
Genetic Diseases, Inborn*/genetics
Genetic Diseases, Inborn*/therapy
Peptide Chain Elongation, Translational*/drug effects
Precision Medicine*/methods
Precision Medicine*/trends
Rare Diseases*/genetics
Rare Diseases*/therapy
Suppression, Genetic*/drug effects
Suppression, Genetic*/genetics
Animals ; Humans ; Breast Neoplasms/genetics ; Breast Neoplasms/therapy ; Cystic Fibrosis/genetics ; Cystic Fibrosis/therapy ; Epidermolysis Bullosa/genetics ; Epidermolysis Bullosa/therapy ; Nephritis, Hereditary/genetics ; Nephritis, Hereditary/therapy ; Nonsense Mediated mRNA Decay ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/therapy ; Shwachman-Diamond Syndrome/genetics ; Shwachman-Diamond Syndrome/therapy ; Peptide Chain Termination, Translational/drug effects ; Aminoglycosides/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Antidiabetic Potential and Chronic Toxicity of Hydroalcoholic Extract of Echeveria subrigida Leaves.
Autorzy:
Heredia-Mercado, Belinda
Delgado-Vargas, Francisco
Ulises Osuna-Martínez, Lorenzo
Noguera-Corona, Elvic
Ángel López-Valenzuela, José
Ramos-Payán, Rosalio
López-Angulo, Gabriela
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Źródło:
Pharmacognosy Research. Apr-Jun2023, Vol. 15 Issue 2, p315-327. 13p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Causes of HIV Treatment Interruption during the Last 20 Years: A Multi-Cohort Real-Life Study.
Autorzy:
De Vito, Andrea (AUTHOR)
Ricci, Elena (AUTHOR)
Menzaghi, Barbara (AUTHOR)
Orofino, Giancarlo (AUTHOR)
Martinelli, Canio Vito (AUTHOR)
Squillace, Nicola (AUTHOR)
Taramasso, Lucia (AUTHOR)
De Socio, Giuseppe Vittorio (AUTHOR)
Molteni, Chiara (AUTHOR)
Valsecchi, Laura (AUTHOR)
Costa, Cecilia (AUTHOR)
Celesia, Benedetto Maurizio (AUTHOR)
Parruti, Giustino (AUTHOR)
Pellicanò, Giovanni Francesco (AUTHOR)
Sarchi, Eleonora (AUTHOR)
Cascio, Antonio (AUTHOR)
Cenderello, Giovanni (AUTHOR)
Falasca, Katia (AUTHOR)
Di Biagio, Antonio (AUTHOR)
Bonfanti, Paolo (AUTHOR)
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Źródło:
Viruses (1999-4915). Mar2023, Vol. 15 Issue 3, p720. 15p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Safety and efficacy of Pucotenlimab (HX008) - a humanized immunoglobulin G4 monoclonal antibody in patients with locally advanced or metastatic melanoma: a single-arm, multicenter, phase II study.
Autorzy:
Cui, Chuanliang (AUTHOR)
Chen, Yu (AUTHOR)
Luo, Zhiguo (AUTHOR)
Zou, Zhengyun (AUTHOR)
Jiang, Yu (AUTHOR)
Pan, Hongming (AUTHOR)
Fan, Qingxia (AUTHOR)
Zhao, Jianfu (AUTHOR)
Xu, Qing (AUTHOR)
Jiang, Renbing (AUTHOR)
Wang, Xuan (AUTHOR)
Ma, Taiyang (AUTHOR)
Guo, Zhen (AUTHOR)
Si, Lu (AUTHOR)
Chi, Zhihong (AUTHOR)
Sheng, Xinan (AUTHOR)
Dou, Yiwei (AUTHOR)
Tan, Qian (AUTHOR)
Wu, Di (AUTHOR)
Guo, Jun (AUTHOR)
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Źródło:
BMC Cancer. 2/6/2023, Vol. 23 Issue 1, p1-11. 11p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae.
Autorzy:
Hoshino S; Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, Japan.
Kanemura R; Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, Japan.
Kurita D; Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki, Japan.
Soutome Y; Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, Japan.
Himeno H; Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki, Japan.
Takaine M; Gunma University Initiative for Advanced Research (GIAR), Gunma University, Maebashi, Japan.; Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.
Watanabe M; Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan.
Nameki N; Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, Japan. .
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Źródło:
Communications biology [Commun Biol] 2021 Mar 08; Vol. 4 (1), pp. 300. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Bacterial Agents/*pharmacology
Mitochondrial Proteins/*metabolism
Mitochondrial Ribosomes/*drug effects
Peptide Termination Factors/*metabolism
Protein Biosynthesis/*drug effects
Ribosomal Proteins/*metabolism
Saccharomyces cerevisiae/*drug effects
Saccharomyces cerevisiae Proteins/*metabolism
Drug Resistance, Fungal ; Gene Expression Regulation, Fungal ; Mitochondrial Proteins/genetics ; Mitochondrial Ribosomes/metabolism ; Mutation ; Peptide Termination Factors/genetics ; RNA, Fungal/genetics ; RNA, Fungal/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Ribosomal Proteins/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies.
Autorzy:
Abhishek, Abhishek (AUTHOR)
Stevenson, Matthew D (AUTHOR)
Nakafero, Georgina (AUTHOR)
Grainge, Matthew J (AUTHOR)
Evans, Ian (AUTHOR)
Alabas, Oras (AUTHOR)
Card, Tim (AUTHOR)
Taal, Maarten W (AUTHOR)
Aithal, Guruprasad P (AUTHOR)
Fox, Christopher P (AUTHOR)
Mallen, Christian D (AUTHOR)
Windt, Danielle A van der (AUTHOR)
Riley, Richard D (AUTHOR)
Warren, Richard B (AUTHOR)
Williams, Hywel C (AUTHOR)
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Źródło:
British Journal of Dermatology. Apr2024, Vol. 190 Issue 4, p559-564. 6p.
Czasopismo naukowe
Szczegóły
Tytuł:
A phase 2 open‐label extension study of prekallikrein inhibition with donidalorsen for hereditary angioedema.
Autorzy:
Petersen, Remy S. (AUTHOR)
Bordone, Laura (AUTHOR)
Riedl, Marc A. (AUTHOR)
Tachdjian, Raffi (AUTHOR)
Craig, Timothy J. (AUTHOR)
Lumry, William R. (AUTHOR)
Manning, Michael E. (AUTHOR)
Bernstein, Jonathan A. (AUTHOR)
Raasch, Jason (AUTHOR)
Zuraw, Bruce L. (AUTHOR)
Deng, Yiwen (AUTHOR)
Newman, Kenneth B. (AUTHOR)
Alexander, Veronica J. (AUTHOR)
Lui, Cindy (AUTHOR)
Schneider, Eugene (AUTHOR)
Cohn, Danny M. (AUTHOR)
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Źródło:
Allergy. Mar2024, Vol. 79 Issue 3, p724-734. 11p.
Czasopismo naukowe
Szczegóły
Tytuł:
Topiramate ban in women of childbearing potential with idiopathic generalized epilepsy: Does effectiveness offset the teratogenic risks?
Autorzy:
Cerulli Irelli, Emanuele (AUTHOR)
Cocchi, Enrico (AUTHOR)
Mostacci, Barbara (AUTHOR)
Orlando, Biagio (AUTHOR)
Gesche, Joanna (AUTHOR)
Caraballo, Roberto H. (AUTHOR)
Lattanzi, Simona (AUTHOR)
Strigaro, Gionata (AUTHOR)
Catania, Cecilia (AUTHOR)
Pulitano, Patrizia (AUTHOR)
Panzini, Chiara (AUTHOR)
Ferlazzo, Edoardo (AUTHOR)
Pascarella, Angelo (AUTHOR)
Casciato, Sara (AUTHOR)
Pizzanelli, Chiara (AUTHOR)
Giuliano, Loretta (AUTHOR)
Viola, Veronica (AUTHOR)
Fortunato, Francesco (AUTHOR)
Di Gennaro, Giancarlo (AUTHOR)
Gambardella, Antonio (AUTHOR)
Pokaż więcej
Źródło:
Epilepsia (Series 4). Mar2024, Vol. 65 Issue 3, pe27-e34. 8p.
Czasopismo naukowe
Szczegóły
Tytuł:
Safety and immunopharmacology of ASP0892 in adults or adolescents with peanut allergy: two randomized trials.
Autorzy:
Ferslew, Brian C. (AUTHOR)
Smulders, Ronald (AUTHOR)
Zhu, Tong (AUTHOR)
Blauwet, Mary B. (AUTHOR)
Kusawake, Tomohiro (AUTHOR)
Spence, Anna (AUTHOR)
Aldridge, Kelly (AUTHOR)
DeBerg, Hannah A. (AUTHOR)
Khosa, Sugandhika (AUTHOR)
Wambre, Erik (AUTHOR)
Chichili, Gurunadh R. (AUTHOR)
Pokaż więcej
Źródło:
Allergy. Feb2024, Vol. 79 Issue 2, p456-470. 15p.
Czasopismo naukowe
Szczegóły
Tytuł:
A principal stratification approach to estimating the effect of continuing treatment after observing early outcomes.
Autorzy:
Schnell, Patrick M. (AUTHOR)
Baumgartner, Richard (AUTHOR)
Mt‐Isa, Shahrul (AUTHOR)
Svetnik, Vladimir (AUTHOR)
Pokaż więcej
Źródło:
Journal of the Royal Statistical Society: Series C (Applied Statistics). Nov2022, Vol. 71 Issue 5, p1065-1084. 20p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bacteria require phase separation for fitness in the mammalian gut.
Autorzy:
Krypotou E; Department of Microbial Pathogenesis, Yale School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.; Yale Microbial Sciences Institute, P.O. Box 27389, West Haven, CT 06516, USA.
Townsend GE; Department of Microbial Pathogenesis, Yale School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.; Yale Microbial Sciences Institute, P.O. Box 27389, West Haven, CT 06516, USA.; Department of Biochemistry and Molecular Biology, Penn State College of Medicine, 700 HMC Crescent Road, Hershey, PA 17033, USA.
Gao X; Department of Microbial Pathogenesis, Yale School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.
Tachiyama S; Department of Microbial Pathogenesis, Yale School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.; Yale Microbial Sciences Institute, P.O. Box 27389, West Haven, CT 06516, USA.
Liu J; Department of Microbial Pathogenesis, Yale School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.; Yale Microbial Sciences Institute, P.O. Box 27389, West Haven, CT 06516, USA.
Pokorzynski ND; Department of Microbial Pathogenesis, Yale School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.
Goodman AL; Department of Microbial Pathogenesis, Yale School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.; Yale Microbial Sciences Institute, P.O. Box 27389, West Haven, CT 06516, USA.
Groisman EA; Department of Microbial Pathogenesis, Yale School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.; Yale Microbial Sciences Institute, P.O. Box 27389, West Haven, CT 06516, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Mar 17; Vol. 379 (6637), pp. 1149-1156. Date of Electronic Publication: 2023 Mar 16.
Typ publikacji:
Journal Article
MeSH Terms:
Bacteroides thetaiotaomicron*/genetics
Bacteroides thetaiotaomicron*/physiology
Gastrointestinal Microbiome*/genetics
Gastrointestinal Microbiome*/physiology
Intrinsically Disordered Proteins*/chemistry
Intrinsically Disordered Proteins*/genetics
Intrinsically Disordered Proteins*/physiology
Bacterial Proteins*/chemistry
Bacterial Proteins*/genetics
Bacterial Proteins*/physiology
RNA Helicases*/chemistry
RNA Helicases*/genetics
RNA Helicases*/physiology
Genetic Fitness*
Rho Factor*/chemistry
Rho Factor*/genetics
Rho Factor*/physiology
Animals ; Humans ; Transcription Termination, Genetic ; Protein Domains ; Mice ; Germ-Free Life ; Mice, Inbred C57BL ; Male ; Female
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Role of ribosome recycling factor in natural termination and translational coupling as a ribosome releasing factor.
Autorzy:
Inokuchi Y; Faculty of Science and Engineering, Department of Biosciences, Teikyo University, Utsunomiya, Japan.
Quaglia F; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Hirashima A; Faculty of Science and Engineering, Department of Biosciences, Teikyo University, Utsunomiya, Japan.
Yamamoto Y; Hyogo College of Medicine, Nishinomiya, Japan.
Kaji H; Department of Biochemistry and Molecular Biology, Jefferson Medical College, Philadelphia, Pennsylvania, United States of America.
Kaji A; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
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Źródło:
PloS one [PLoS One] 2023 Feb 24; Vol. 18 (2), pp. e0282091. Date of Electronic Publication: 2023 Feb 24 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Escherichia coli*/genetics
Ribosomal Proteins*/genetics
Ribosomes/genetics ; Codon, Terminator ; Peptide Chain Termination, Translational/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Treatment of Primary Nummular Headache: A Series of 183 Patients from the NUMITOR Study.
Autorzy:
García-Iglesias, Cristina (AUTHOR)
Puledda, Francesca (AUTHOR)
Echavarría-Íñiguez, Ana (AUTHOR)
González-Osorio, Yesica (AUTHOR)
Sierra-Mencía, Álvaro (AUTHOR)
Recio-García, Andrea (AUTHOR)
González-Celestino, Ana (AUTHOR)
Valle-Peñacoba, Gonzalo (AUTHOR)
Irimia, Pablo (AUTHOR)
Guerrero-Peral, Ángel Luis (AUTHOR)
García-Azorín, David (AUTHOR)
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Źródło:
Journal of Clinical Medicine. Jan2023, Vol. 12 Issue 1, p122. 9p.
Czasopismo naukowe
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Tytuł:
Pharmacological treatment for methamphetamine withdrawal: A systematic review and meta‐analysis of randomised controlled trials.
Autorzy:
Acheson, Liam S. (AUTHOR)
Williams, Benjamin H. (AUTHOR)
Farrell, Michael (AUTHOR)
McKetin, Rebecca (AUTHOR)
Ezard, Nadine (AUTHOR)
Siefried, Krista J. (AUTHOR)
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Źródło:
Drug & Alcohol Review. Jan2023, Vol. 42 Issue 1, p7-19. 13p. 2 Diagrams, 2 Charts.
Czasopismo naukowe
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Tytuł:
فاعلية استخدام إسرتاتيجية الرسم الرسيع عل حتسني مهارات حّل املسائل الرياضية اللفظية لدى الطالبات ذواتلم الرياضيات صعوبات تعُ.
Autorzy:
حكمت مهدي آل مشري
مريم فيصل النعيم
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Alternatywny tytuł:
The Effectiveness of Using Fast Draw Strategy to Improve the Skills of Solving Mathematical Verbal Problems for Students with math learning Disabilities.
Źródło:
Journal of Educational Sciences. Jan2023, Vol. 35 Issue 1, p81-111. 31p.
Czasopismo naukowe
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Tytuł:
Clinical characteristics and outcomes of antibiotic-associated encephalopathy in patients with end-stage kidney disease.
Autorzy:
Huang, Qingxiu (AUTHOR)
Li, Jianbo (AUTHOR)
Huang, Naya (AUTHOR)
Xia, Xi (AUTHOR)
Qiu, Yagui (AUTHOR)
Zhong, Zhong (AUTHOR)
Lin, Zhenchuan (AUTHOR)
Huang, Xiaowen (AUTHOR)
Zhang, Dihua (AUTHOR)
Huang, Fengxian (AUTHOR)
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Źródło:
Renal Failure. Dec2022, Vol. 44 Issue 1, p1709-1717. 9p.
Czasopismo naukowe
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Tytuł:
When and how do we stop antifungal treatment for an invasive mould infection in allogeneic haematopoietic cell transplant recipients?
Autorzy:
Roth, Romain Samuel (AUTHOR)
Masouridi‐Levrat, Stavroula (AUTHOR)
Giannotti, Federica (AUTHOR)
Mamez, Anne‐Claire (AUTHOR)
Morin, Sarah (AUTHOR)
van Delden, Christian (AUTHOR)
Chalandon, Yves (AUTHOR)
Neofytos, Dionysios (AUTHOR)
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Źródło:
Mycoses. Nov2022, Vol. 65 Issue 11, p1061-1067. 7p.
Czasopismo naukowe
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Tytuł:
Global analysis of translation termination in E. coli.
Autorzy:
Baggett NE; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America.
Zhang Y; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America.
Gross CA; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America.; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California, United States of America.; California Institute of Quantitative Biology, University of California, San Francisco, San Francisco, California, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2017 Mar 16; Vol. 13 (3), pp. e1006676. Date of Electronic Publication: 2017 Mar 16 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Escherichia coli/*genetics
Escherichia coli Proteins/*genetics
Peptide Chain Termination, Translational/*genetics
Protein Biosynthesis/*genetics
Amino Acid Sequence ; Blotting, Western ; Codon, Terminator/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Bacterial ; Mutation ; Oligonucleotide Array Sequence Analysis/methods ; Operon/genetics ; Peptide Termination Factors/genetics ; Peptide Termination Factors/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Ribosomes/genetics ; Ribosomes/metabolism ; Temperature
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Reconstitution of yeast translation elongation and termination in vitro utilizing CrPV IRES-containing mRNA.
Autorzy:
Abe T; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5, Kashiwanoha, Kashiwa-shi, Chiba 277-8562, Japan.
Nagai R; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5, Kashiwanoha, Kashiwa-shi, Chiba 277-8562, Japan.
Imataka H; Department of Materials Science and Chemistry, Graduate School of Engineering, University of Hyogo, Himeji 671-2201, Japan.
Takeuchi-Tomita N; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5, Kashiwanoha, Kashiwa-shi, Chiba 277-8562, Japan.
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Źródło:
Journal of biochemistry [J Biochem] 2020 May 01; Vol. 167 (5), pp. 441-450.
Typ publikacji:
Journal Article
MeSH Terms:
Peptide Chain Elongation, Translational*
Peptide Chain Termination, Translational*
Peptides/*metabolism
RNA, Messenger/*metabolism
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae/*metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Clustering and Fibril Formation during GNNQQNY Aggregation: A Molecular Dynamics Study.
Autorzy:
Szała-Mendyk B; Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89b, 61-614 Poznań, Poland.
Molski A; Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89b, 61-614 Poznań, Poland.
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Źródło:
Biomolecules [Biomolecules] 2020 Sep 24; Vol. 10 (10). Date of Electronic Publication: 2020 Sep 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyloid/*ultrastructure
Peptide Termination Factors/*ultrastructure
Peptides/*chemistry
Prion Proteins/*ultrastructure
Saccharomyces cerevisiae Proteins/*ultrastructure
Amyloid/genetics ; Humans ; Kinetics ; Molecular Dynamics Simulation ; Peptide Termination Factors/genetics ; Peptides/genetics ; Prion Proteins/genetics ; Protein Aggregates/genetics ; Protein Aggregation, Pathological/genetics ; Protein Conformation ; Protein Conformation, alpha-Helical/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/ultrastructure ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Translation factors direct intrinsic ribosome dynamics during translation termination and ribosome recycling.
Autorzy:
Sternberg SH; Department of Chemistry, Columbia University, New York, New York, USA.
Fei J
Prywes N
McGrath KA
Gonzalez RL Jr
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Źródło:
Nature structural & molecular biology [Nat Struct Mol Biol] 2009 Aug; Vol. 16 (8), pp. 861-8. Date of Electronic Publication: 2009 Jul 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Peptide Chain Termination, Translational*
Peptide Termination Factors/*metabolism
Ribosomal Proteins/*metabolism
Ribosomes/*metabolism
Carbocyanines/chemistry ; Electrophoresis, Polyacrylamide Gel ; Fluorescence ; Kinetics ; Models, Biological ; Peptide Termination Factors/chemistry ; Peptide Termination Factors/genetics ; Protein Binding ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Ribosomal Proteins/chemistry ; Ribosomal Proteins/genetics ; Ribosomes/chemistry ; Ribosomes/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Aggregation and Prion-Inducing Properties of the G-Protein Gamma Subunit Ste18 are Regulated by Membrane Association.
Autorzy:
Chernova TA; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
Yang Z; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
Karpova TS; Center for Cancer Research Core Fluorescence Imaging Facility, Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Shanks JR; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
Shcherbik N; Department of Cell Biology, Rowan University, School of Osteopathic Medicine, Stratford, NJ 08084, USA.
Wilkinson KD; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
Chernoff YO; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332-2000, USA.; Laboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Jul 16; Vol. 21 (14). Date of Electronic Publication: 2020 Jul 16.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Aggregates*
GTP-Binding Protein gamma Subunits/*metabolism
Peptide Termination Factors/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Cell Membrane/metabolism ; GTP-Binding Protein gamma Subunits/analysis ; Peptide Termination Factors/analysis ; Proteolysis ; Saccharomyces cerevisiae/ultrastructure ; Saccharomyces cerevisiae Proteins/analysis ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparison of randomized controlled trials discontinued or revised for poor recruitment and completed trials with the same research question: a matched qualitative study.
Autorzy:
Briel M; Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland. .; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. .
Speich B; Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland.
von Elm E; Cochrane Switzerland, Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Gloy V; Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland.
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Źródło:
Trials [Trials] 2019 Dec 30; Vol. 20 (1), pp. 800. Date of Electronic Publication: 2019 Dec 30.
Typ publikacji:
Journal Article
MeSH Terms:
Early Termination of Clinical Trials*
Patient Selection*
Randomized Controlled Trials as Topic*
Eligibility Determination/methods ; Financial Support ; Humans ; Motivation ; Qualitative Research ; Research Personnel/economics ; Risk Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Yeast Sup35 Prion Structure: Two Types, Four Parts, Many Variants.
Autorzy:
Dergalev AA; A.N. Bach Institute of Biochemistry, Federal Research Center 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow 119071, Russia. .
Alexandrov AI; A.N. Bach Institute of Biochemistry, Federal Research Center 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow 119071, Russia. .
Ivannikov RI; A.N. Bach Institute of Biochemistry, Federal Research Center 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow 119071, Russia. ivannikov_.
Ter-Avanesyan MD; A.N. Bach Institute of Biochemistry, Federal Research Center 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow 119071, Russia.
Kushnirov VV; A.N. Bach Institute of Biochemistry, Federal Research Center 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow 119071, Russia. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 May 29; Vol. 20 (11). Date of Electronic Publication: 2019 May 29.
Typ publikacji:
Journal Article
MeSH Terms:
Peptide Termination Factors/*metabolism
Prions/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Endopeptidase K/metabolism ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Peptide Termination Factors/chemistry ; Peptide Termination Factors/genetics ; Prions/chemistry ; Prions/genetics ; Protein Domains ; Protein Multimerization ; Proteolysis ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418.
Autorzy:
Ferguson MW; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Gerak CAN; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Chow CCT; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Rastelli EJ; Department of Chemistry, University of Houston, Houston, Texas, United States of America.
Elmore KE; Department of Chemistry, University of Houston, Houston, Texas, United States of America.
Stahl F; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Hosseini-Farahabadi S; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Baradaran-Heravi A; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Coltart DM; Department of Chemistry, University of Houston, Houston, Texas, United States of America.
Roberge M; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
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Źródło:
PloS one [PLoS One] 2019 May 23; Vol. 14 (5), pp. e0216423. Date of Electronic Publication: 2019 May 23 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Codon, Nonsense*
Codon, Terminator*
Peptide Chain Termination, Translational*/drug effects
Peptide Chain Termination, Translational*/genetics
Tumor Suppressor Protein p53*/biosynthesis
Tumor Suppressor Protein p53*/genetics
Antimalarials/*pharmacology
Gentamicins/*pharmacology
Mefloquine/*pharmacology
HCT116 Cells ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structural basis for translation termination on the 70S ribosome.
Autorzy:
Laurberg M; Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California at Santa Cruz, Santa Cruz, California 95064, USA.
Asahara H
Korostelev A
Zhu J
Trakhanov S
Noller HF
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Źródło:
Nature [Nature] 2008 Aug 14; Vol. 454 (7206), pp. 852-7. Date of Electronic Publication: 2008 Jul 02.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Peptide Chain Termination, Translational*
Ribosomes/*chemistry
Ribosomes/*metabolism
Thermus thermophilus/*chemistry
Codon, Terminator/genetics ; Codon, Terminator/metabolism ; Crystallography, X-Ray ; Models, Molecular ; Peptide Termination Factors/chemistry ; Peptide Termination Factors/metabolism ; Peptidyl Transferases/chemistry ; Peptidyl Transferases/metabolism ; Protein Binding ; Protein Structure, Tertiary ; RNA, Bacterial/metabolism ; RNA, Ribosomal, 23S/chemistry ; RNA, Transfer/chemistry ; RNA, Transfer/genetics ; RNA, Transfer/metabolism ; Thermus thermophilus/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Mutability of Yeast Prions.
Autorzy:
King CY; Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan.
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Źródło:
Viruses [Viruses] 2022 Oct 25; Vol. 14 (11). Date of Electronic Publication: 2022 Oct 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Prions*/genetics
Prions*/metabolism
Saccharomyces cerevisiae Proteins*/chemistry
Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Peptide Termination Factors/chemistry ; Peptide Termination Factors/metabolism ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hsp40/JDP Requirements for the Propagation of Synthetic Yeast Prions.
Autorzy:
Miller SC; Department of Chemistry, Lafayette College, Easton, PA 18042, USA.
Wegrzynowicz AK; Department of Chemistry, Lafayette College, Easton, PA 18042, USA.
Cole SJ; Department of Chemistry, Lafayette College, Easton, PA 18042, USA.
Hayward RE; Department of Chemistry, Lafayette College, Easton, PA 18042, USA.
Ganser SJ; Department of Chemistry, Lafayette College, Easton, PA 18042, USA.
Hines JK; Department of Chemistry, Lafayette College, Easton, PA 18042, USA.
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Źródło:
Viruses [Viruses] 2022 Sep 30; Vol. 14 (10). Date of Electronic Publication: 2022 Sep 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Prions*/chemistry
Saccharomyces cerevisiae Proteins*/chemistry
Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Molecular Chaperones/metabolism ; HSP70 Heat-Shock Proteins/metabolism ; Amyloid/chemistry ; Amyloidogenic Proteins/metabolism ; Amino Acids/metabolism ; Recombinant Fusion Proteins/metabolism ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Peptide Termination Factors/genetics ; Peptide Termination Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Trial protocol of an open label pilot study of lisdexamfetamine for the treatment of acute methamphetamine withdrawal.
Autorzy:
Acheson, Liam S. (AUTHOR)
Ezard, Nadine (AUTHOR)
Lintzeris, Nicholas (AUTHOR)
Dunlop, Adrian (AUTHOR)
Brett, Jonathan (AUTHOR)
Rodgers, Craig (AUTHOR)
Gill, Anthony (AUTHOR)
Christmass, Michael (AUTHOR)
McKetin, Rebecca (AUTHOR)
Farrell, Michael (AUTHOR)
Shoptaw, Steve (AUTHOR)
Siefried, Krista J. (AUTHOR)
Pokaż więcej
Źródło:
PLoS ONE. 10/3/2022, Vol. 17 Issue 10, p1-13. 13p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Specialized inpatient treatment for young people with early psychosis: acute-treatment and 12-month results.
Autorzy:
Siebert, Stefan (AUTHOR)
Leopold, Karolina (AUTHOR)
Baumgardt, Johanna (AUTHOR)
von Hardenberg, Laura-Sophie (AUTHOR)
Burkhardt, Eva (AUTHOR)
Bechdolf, Andreas (AUTHOR)
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Źródło:
European Archives of Psychiatry & Clinical Neuroscience. Oct2022, Vol. 272 Issue 7, p1-14. 14p. 4 Charts.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Reasons and Determinants of BoNT-A Treatment Discontinuation in Patients Living with Spasticity: A 10-Year Retrospective Analysis.
Autorzy:
Cinone, Nicoletta (AUTHOR)
Santoro, Luigi (AUTHOR)
Spina, Stefania (AUTHOR)
Facciorusso, Salvatore (AUTHOR)
Battaglia, Marco (AUTHOR)
Baricich, Alessio (AUTHOR)
Marcogiuseppe, Pasqua (AUTHOR)
Santamato, Andrea (AUTHOR)
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Źródło:
Toxins. Oct2022, Vol. 14 Issue 10, pN.PAG-N.PAG. 12p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Clinical outcomes of treatment with idebenone in Leber's hereditary optic neuropathy in the Netherlands: A national cohort study.
Autorzy:
van Everdingen, Judith A. M. (AUTHOR)
Pott, Jan Willem R. (AUTHOR)
Bauer, Noël J. C. (AUTHOR)
Krijnen, Anna M. (AUTHOR)
Lushchyk, Tanya (AUTHOR)
Wubbels, René J. (AUTHOR)
Pokaż więcej
Źródło:
Acta Ophthalmologica (1755375X). Sep2022, Vol. 100 Issue 6, p700-706. 7p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Durability of Response to Abrocitinib in Patients with Moderate-to-Severe Atopic Dermatitis After Treatment Discontinuation in a Phase 2b Trial.
Autorzy:
Gooderham, Melinda J. (AUTHOR)
Girolomoni, Giampiero (AUTHOR)
Moore, Julian O. (AUTHOR)
Silverberg, Jonathan I. (AUTHOR)
Bissonnette, Robert (AUTHOR)
Forman, Seth (AUTHOR)
Peeva, Elena (AUTHOR)
Biswas, Pinaki (AUTHOR)
Valdez, Hernan (AUTHOR)
Chan, Gary (AUTHOR)
Pokaż więcej
Źródło:
Dermatology & Therapy. Sep2022, Vol. 12 Issue 9, p2077-2085. 9p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Atogepant for the Prevention of Episodic Migraine in Adults: A Systematic Review and Meta-Analysis of Efficacy and Safety.
Autorzy:
Lattanzi, Simona (AUTHOR)
Trinka, Eugen (AUTHOR)
Altamura, Claudia (AUTHOR)
Del Giovane, Cinzia (AUTHOR)
Silvestrini, Mauro (AUTHOR)
Brigo, Francesco (AUTHOR)
Vernieri, Fabrizio (AUTHOR)
Pokaż więcej
Źródło:
Neurology & Therapy. Sep2022, Vol. 11 Issue 3, p1235-1252. 18p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-100 z 29935

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