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Wyszukujesz frazę ""TETRAHYDROISOQUINOLINES"" wg kryterium: Temat


Tytuł :
Syntheses of 3-Aryl Tetrahydroisoquinolines via an Intermolecular [4 + 2] Cycloaddition of Sultines with Imines.
Autorzy :
Ngamnithiporn A; Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Road, Bangkok 10210, Thailand.
Chuentragool P; Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Road, Bangkok 10210, Thailand.
Ploypradith P; Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Road, Bangkok 10210, Thailand.; Program in Chemical Sciences, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok 10210, Thailand.; Center of Excellence on Environmental Health and Toxicology, Office of the Permanent Secretary (OPS), Ministry of Higher Education, Science, Research and Innovation (MHESI), Bangkok 10400, Thailand.
Ruchirawat S; Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Road, Bangkok 10210, Thailand.; Program in Chemical Sciences, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok 10210, Thailand.; Center of Excellence on Environmental Health and Toxicology, Office of the Permanent Secretary (OPS), Ministry of Higher Education, Science, Research and Innovation (MHESI), Bangkok 10400, Thailand.
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Źródło :
Organic letters [Org Lett] 2022 Jun 17; Vol. 24 (23), pp. 4192-4196. Date of Electronic Publication: 2022 May 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Imines*
Tetrahydroisoquinolines*
Cyclization ; Cycloaddition Reaction ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Cell Fate following Irradiation of MDA-MB-231 and MCF-7 Breast Cancer Cells Pre-Exposed to the Tetrahydroisoquinoline Sulfamate Microtubule Disruptor STX3451.
Autorzy :
Hargrave SD; Department of Physiology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
Joubert AM; Department of Physiology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
Potter BVL; Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
Dohle W; Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
Marais S; Department of Physiology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
Mercier AE; Department of Physiology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2022 Jun 14; Vol. 27 (12). Date of Electronic Publication: 2022 Jun 14.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*/metabolism
Tetrahydroisoquinolines*/pharmacology
2-Methoxyestradiol/pharmacology ; Apoptosis ; Cell Line, Tumor ; Female ; Humans ; MCF-7 Cells ; Microtubules/metabolism ; Sulfonic Acids
Czasopismo naukowe
Tytuł :
Facile Synthesis of Tricyclic 1,2,4-Oxadiazolines-Fused Tetrahydro-Isoquinolines from Oxime Chlorides with 3,4-Dihydroisoquinoline Imines.
Autorzy :
Wang K; School of Pharmacy, Xinxiang University, Xinxiang 453000, China.; Key Laboratory of Nano-Carbon Modified Film Technology Engineering of Henan Province, Xinxiang 453000, China.
Li Y; Medical College, Xinxiang University, Xinxiang 453000, China.
Zhang W; School of Pharmacy, Xinxiang University, Xinxiang 453000, China.
Chen R; School of Pharmacy, Xinxiang University, Xinxiang 453000, China.
Ma X; School of Pharmacy, Xinxiang University, Xinxiang 453000, China.; Key Laboratory of Nano-Carbon Modified Film Technology Engineering of Henan Province, Xinxiang 453000, China.
Wang M; School of Pharmacy, Xinxiang University, Xinxiang 453000, China.
Zhou N; School of Pharmacy, Xinxiang University, Xinxiang 453000, China.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2022 May 10; Vol. 27 (10). Date of Electronic Publication: 2022 May 10.
Typ publikacji :
Journal Article
MeSH Terms :
Imines*/chemistry
Tetrahydroisoquinolines*
Chlorides ; Isoquinolines ; Oximes
Czasopismo naukowe
Tytuł :
Trabectedin and Durvalumab Combination Is Feasible and Active in Relapsing Ovarian Cancer.
Autorzy :
Digklia A; Department of Oncology, Medical Oncology Service, Lausanne University Hospital, Lausanne, Switzerland.; University of Lausanne, Lausanne, Switzerland.
Coukos G; University of Lausanne, Lausanne, Switzerland.; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Lausanne, Switzerland.; Department of Oncology, Immuno-oncology Service, Lausanne University Hospital, Lausanne, Switzerland.
Homicsko K; University of Lausanne, Lausanne, Switzerland.; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Lausanne, Switzerland.; Department of Oncology, Immuno-oncology Service, Lausanne University Hospital, Lausanne, Switzerland.; Center for Personalized Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2022 May 02; Vol. 28 (9), pp. 1745-1747.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/pathology
Sarcoma*/drug therapy
Soft Tissue Neoplasms*/drug therapy
Tetrahydroisoquinolines*/adverse effects
Antibodies, Monoclonal ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Carcinoma, Ovarian Epithelial/drug therapy ; Dioxoles/adverse effects ; Female ; Humans ; Neoplasm Recurrence, Local/drug therapy ; Trabectedin
Opinia redakcyjna
Tytuł :
Advances in Sulfonamide Kappa Opioid Receptor Antagonists: Structural Refinement and Evaluation of CNS Clearance.
Autorzy :
Ma H; Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, 125 Mason Farm Road, CB 7363, Chapel Hill, North Carolina 27599, United States.; Department of Medicinal Chemistry, University of Kansas, 2034 Becker Drive, Lawrence, Kansas 66047, United States.
Brust T; Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, 130 Scripps Way, #2A2, Jupiter, Florida 33458, United States.
Frankowski KJ; Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, 125 Mason Farm Road, CB 7363, Chapel Hill, North Carolina 27599, United States.; Department of Medicinal Chemistry, University of Kansas, 2034 Becker Drive, Lawrence, Kansas 66047, United States.
Lovell KM; Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, 130 Scripps Way, #2A2, Jupiter, Florida 33458, United States.
Cameron MD; Department of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, #2A1, Jupiter, Florida 33458, United States.
Bohn LM; Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, 130 Scripps Way, #2A2, Jupiter, Florida 33458, United States.
Aubé J; Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, 125 Mason Farm Road, CB 7363, Chapel Hill, North Carolina 27599, United States.; Department of Medicinal Chemistry, University of Kansas, 2034 Becker Drive, Lawrence, Kansas 66047, United States.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2022 Apr 20; Vol. 13 (8), pp. 1315-1332. Date of Electronic Publication: 2022 Apr 11.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, N.I.H., Extramural
MeSH Terms :
Receptors, Opioid, kappa*
Tetrahydroisoquinolines*/chemistry
Narcotic Antagonists/chemistry ; Narcotic Antagonists/pharmacology ; Sulfonamides/pharmacology
Czasopismo naukowe
Tytuł :
Synthesis and biological evaluation of tetrahydroisoquinoline-derived antibacterial compounds.
Autorzy :
Payne M; School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Broadway, NSW, 2007, Australia.
Bottomley AL; The ithree Institute, University of Technology Sydney, Broadway, NSW, 2007, Australia.
Och A; School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Broadway, NSW, 2007, Australia.
Hiscocks HG; School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Broadway, NSW, 2007, Australia.
Asmara AP; School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Broadway, NSW, 2007, Australia.
Harry EJ; The ithree Institute, University of Technology Sydney, Broadway, NSW, 2007, Australia.
Ung AT; School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Broadway, NSW, 2007, Australia. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Mar 01; Vol. 57, pp. 116648. Date of Electronic Publication: 2022 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Mycobacterium tuberculosis/*drug effects
Staphylococcus aureus/*drug effects
Tetrahydroisoquinolines/*pharmacology
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Molecular Structure ; Structure-Activity Relationship ; Tetrahydroisoquinolines/chemical synthesis ; Tetrahydroisoquinolines/chemistry
Czasopismo naukowe
Tytuł :
Screening of σ 2 Receptor Ligands and In Vivo Evaluation of C-Labeled 6,7-Dimethoxy-2-[4-(4-methoxyphenyl)butan-2-yl]-1,2,3,4-tetrahydroisoquinoline for Potential Use as a σ 2 Receptor Brain PET Tracer.
Autorzy :
Kim HY; Department of Radiology, University of Pennsylvania, Vagelos Laboratories, 1012, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Lee JY; Department of Radiology, University of Pennsylvania, Vagelos Laboratories, 1012, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Hsieh CJ; Department of Radiology, University of Pennsylvania, Vagelos Laboratories, 1012, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Riad A; Department of Radiology, University of Pennsylvania, Vagelos Laboratories, 1012, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Izzo NJ; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania 15203-5118, United States.
Catalano SM; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania 15203-5118, United States.
Graham TJA; Department of Radiology, University of Pennsylvania, Vagelos Laboratories, 1012, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Mach RH; Department of Radiology, University of Pennsylvania, Vagelos Laboratories, 1012, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2022 Apr 28; Vol. 65 (8), pp. 6261-6272. Date of Electronic Publication: 2022 Apr 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Receptors, sigma*
Tetrahydroisoquinolines*/chemistry
Brain/diagnostic imaging ; Brain/metabolism ; Ligands ; Positron-Emission Tomography ; Radiopharmaceuticals/chemistry
Czasopismo naukowe
Tytuł :
Synthesis of Polycyclic Tetrahydroisoquinolines and Tetrahydrobenzo[ d ]azepines from Polymer-Supported Allylglycine.
Autorzy :
Králová P; Department of Organic Chemistry, Faculty of Science, Palacký University, 771 46 Olomouc, Czech Republic.
Soural M; Department of Organic Chemistry, Faculty of Science, Palacký University, 771 46 Olomouc, Czech Republic.; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 5, 779 00 Olomouc, Czech Republic.
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Źródło :
The Journal of organic chemistry [J Org Chem] 2022 Apr 15; Vol. 87 (8), pp. 5242-5256. Date of Electronic Publication: 2022 Mar 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Azepines*
Tetrahydroisoquinolines*
Allylglycine ; Cyclization ; Polymers
Czasopismo naukowe
Tytuł :
Tethered photocatalyst-directed palladium-catalysed C-H allenylation of N -aryl tetrahydroisoquinolines.
Autorzy :
Li M; Department of Chemistry, Faculty of Science, National University of Singapore, 3 Science Drive 3, 117543, Singapore. .
Chia XL; Department of Chemistry, Faculty of Science, National University of Singapore, 3 Science Drive 3, 117543, Singapore. .
Zhu Y; Department of Chemistry, Faculty of Science, National University of Singapore, 3 Science Drive 3, 117543, Singapore. .
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Źródło :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2022 Apr 12; Vol. 58 (30), pp. 4719-4722. Date of Electronic Publication: 2022 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
Tetrahydroisoquinolines*
Transition Elements*
Catalysis ; Palladium
Czasopismo naukowe
Tytuł :
Single-Center Experience with Trabectedin for the Treatment of Non-L-sarcomas.
Autorzy :
Cerdà Serdà P; Medical Oncology Department, Hospital de la Santa Creu i Sant Pau, Carrer de Sant Quintí, 89, 08041, Barcelona, Spain. .
Terés R; Medical Oncology Department, Hospital de la Santa Creu i Sant Pau, Carrer de Sant Quintí, 89, 08041, Barcelona, Spain.
Sebio A; Medical Oncology Department, Hospital de la Santa Creu i Sant Pau, Carrer de Sant Quintí, 89, 08041, Barcelona, Spain.
Bagué S; Department of Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Orellana R; Department of Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Moreno ME; Pharmacy Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Riba M; Pharmacy Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
López-Pousa A; Medical Oncology Department, Hospital de la Santa Creu i Sant Pau, Carrer de Sant Quintí, 89, 08041, Barcelona, Spain.
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Źródło :
Advances in therapy [Adv Ther] 2022 Apr; Vol. 39 (4), pp. 1596-1610. Date of Electronic Publication: 2022 Feb 07.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Sarcoma*/drug therapy
Soft Tissue Neoplasms*/drug therapy
Soft Tissue Neoplasms*/pathology
Tetrahydroisoquinolines*/therapeutic use
Adult ; Antineoplastic Agents, Alkylating/adverse effects ; Dioxoles/adverse effects ; Humans ; Retrospective Studies ; Trabectedin/therapeutic use
Czasopismo naukowe
Tytuł :
Sal synthase induced cytotoxicity of PC12 cells through production of the dopamine metabolites salsolinol and N-methyl-salsolinol.
Autorzy :
Xiong Q; Beijing Key Laboratory of Environmental and Viral Oncology, Beijing International Science and Technology Cooperation Base for Antiviral Drugs, Faculty of Environment and Life, Beijing University of Technology, 100124 Beijing, China.
Zheng X; Beijing Key Laboratory of Environmental and Viral Oncology, Beijing International Science and Technology Cooperation Base for Antiviral Drugs, Faculty of Environment and Life, Beijing University of Technology, 100124 Beijing, China.; Beijing Institute of Biological Products Company Limited, 100176 Beijing, China.
Wang J; Beijing Key Laboratory of Environmental and Viral Oncology, Beijing International Science and Technology Cooperation Base for Antiviral Drugs, Faculty of Environment and Life, Beijing University of Technology, 100124 Beijing, China.
Chen Z; School of Life Science, Beijing Institute of Technology, 100081 Beijing, China.
Deng Y; School of Life Science, Beijing Institute of Technology, 100081 Beijing, China.
Zhong R; Beijing Key Laboratory of Environmental and Viral Oncology, Beijing International Science and Technology Cooperation Base for Antiviral Drugs, Faculty of Environment and Life, Beijing University of Technology, 100124 Beijing, China.
Wang J; Beijing Key Laboratory of Environmental and Viral Oncology, Beijing International Science and Technology Cooperation Base for Antiviral Drugs, Faculty of Environment and Life, Beijing University of Technology, 100124 Beijing, China.
Chen X; Beijing Key Laboratory of Environmental and Viral Oncology, Beijing International Science and Technology Cooperation Base for Antiviral Drugs, Faculty of Environment and Life, Beijing University of Technology, 100124 Beijing, China.
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Źródło :
Journal of integrative neuroscience [J Integr Neurosci] 2022 Mar 23; Vol. 21 (2), pp. 71.
Typ publikacji :
Journal Article
MeSH Terms :
Dopamine*/chemistry
Dopamine*/metabolism
Tetrahydroisoquinolines*
Animals ; Humans ; Isoquinolines/chemistry ; Isoquinolines/metabolism ; Mammals/metabolism ; PC12 Cells ; Rats
Czasopismo naukowe
Tytuł :
Discovery and optimization of new 6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline derivatives as potent influenza virus PA N inhibitors.
Autorzy :
Liu Z; Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China.
Gu S; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Zhu X; Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.
Liu M; Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China.
Cao Z; Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China.
Qiu P; Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China.
Li S; Department of Human Anatomy, School of Medicine, Jinan University, Guangzhou, 510632, China. Electronic address: .
Liu S; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China. Electronic address: .
Song G; Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2022 Jan 05; Vol. 227, pp. 113929. Date of Electronic Publication: 2021 Oct 19.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Antiviral Agents/*pharmacology
Endonucleases/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Influenza A Virus, H1N1 Subtype/*drug effects
Tetrahydroisoquinolines/*pharmacology
Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Cell Survival/drug effects ; Dogs ; Dose-Response Relationship, Drug ; Endonucleases/metabolism ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Madin Darby Canine Kidney Cells/drug effects ; Madin Darby Canine Kidney Cells/virology ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship ; Tetrahydroisoquinolines/chemical synthesis ; Tetrahydroisoquinolines/chemistry
Czasopismo naukowe
Tytuł :
Synthesis and evaluation of tetrahydroisoquinoline derivatives against Trypanosoma brucei rhodesiense.
Autorzy :
Cullen DR; School of Molecular and Life Sciences - Curtin University, GPO Box U1987, Perth, WA, 6845, Australia.
Gallagher A; School of Molecular and Life Sciences - Curtin University, GPO Box U1987, Perth, WA, 6845, Australia. Electronic address: .
Duncan CL; School of Molecular and Life Sciences - Curtin University, GPO Box U1987, Perth, WA, 6845, Australia.
Pengon J; BIOTEC Medical Molecular Biotechnology Research Group - National Science and Technology Development Agency, 113 Thailand Science Park, Phahonyothin Road, Khlong Luang, Pathum Thani, 12120, Thailand.
Rattanajak R; BIOTEC Medical Molecular Biotechnology Research Group - National Science and Technology Development Agency, 113 Thailand Science Park, Phahonyothin Road, Khlong Luang, Pathum Thani, 12120, Thailand.
Chaplin J; Epichem Pty Ltd. Suite 5, 3 Brodie-Hall Drive Bentley, WA, 6102, Australia.
Gunosewoyo H; Curtin Medical School - Curtin University, GPO Box U1987, Perth, WA, 6845, Australia.
Kamchonwongpaisan S; BIOTEC Medical Molecular Biotechnology Research Group - National Science and Technology Development Agency, 113 Thailand Science Park, Phahonyothin Road, Khlong Luang, Pathum Thani, 12120, Thailand.
Payne A; School of Molecular and Life Sciences - Curtin University, GPO Box U1987, Perth, WA, 6845, Australia.
Mocerino M; School of Molecular and Life Sciences - Curtin University, GPO Box U1987, Perth, WA, 6845, Australia. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Dec 15; Vol. 226, pp. 113861. Date of Electronic Publication: 2021 Sep 24.
Typ publikacji :
Journal Article
MeSH Terms :
Tetrahydroisoquinolines/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosoma brucei rhodesiense/*drug effects
Dose-Response Relationship, Drug ; Molecular Structure ; Parasitic Sensitivity Tests ; Structure-Activity Relationship ; Tetrahydroisoquinolines/chemical synthesis ; Tetrahydroisoquinolines/chemistry ; Trypanocidal Agents/chemical synthesis ; Trypanocidal Agents/chemistry
Czasopismo naukowe
Tytuł :
Lithioarene Cycliacylation and Pd-Catalyzed Aminoethylation/Cyclization to Access Electronically Diverse Saturated Isoquinoline Derivatives.
Autorzy :
Buchman M; Centralized Medicinal Chemistry, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Farney EP; Centralized Medicinal Chemistry, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Greszler SN; Centralized Medicinal Chemistry, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Altenbach RJ; Centralized Medicinal Chemistry, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Gfesser GA; Centralized Medicinal Chemistry, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Voight EA; Centralized Medicinal Chemistry, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
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Źródło :
The Journal of organic chemistry [J Org Chem] 2022 Jan 07; Vol. 87 (1), pp. 776-789. Date of Electronic Publication: 2021 Dec 23.
Typ publikacji :
Journal Article
MeSH Terms :
Palladium*
Tetrahydroisoquinolines*
Catalysis ; Cyclization ; Isoquinolines
Czasopismo naukowe
Tytuł :
Metal-Free Annulation of 2-Nitrobenzyl Alcohols and Tetrahydroisoquinolines toward the Divergent Synthesis of Quinazolinones and Quinazolinethiones.
Autorzy :
Ly D; Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City 700000, Vietnam.; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City 700000, Vietnam.
Nguyen TT; Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City 700000, Vietnam.; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City 700000, Vietnam.
Tran CTH; Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City 700000, Vietnam.; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City 700000, Vietnam.
Nguyen VPT; Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City 700000, Vietnam.; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City 700000, Vietnam.
Nguyen KX; Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City 700000, Vietnam.; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City 700000, Vietnam.
Pham PH; Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City 700000, Vietnam.; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City 700000, Vietnam.
Le NTH; Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City 700000, Vietnam.; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City 700000, Vietnam.
Nguyen TT; Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City 700000, Vietnam.; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City 700000, Vietnam.
Phan NTS; Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City 700000, Vietnam.; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City 700000, Vietnam.
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Źródło :
The Journal of organic chemistry [J Org Chem] 2022 Jan 07; Vol. 87 (1), pp. 103-113. Date of Electronic Publication: 2021 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Tetrahydroisoquinolines*
Metals ; Quinazolinones
Czasopismo naukowe
Tytuł :
Rifampin and ritonavir increase oral availability and elacridar enhances overall exposure and brain accumulation of the NTRK inhibitor larotrectinib.
Autorzy :
Wang Y; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Sparidans RW; Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacology, Universiteitsweg 99, 3584 CG Utrecht, the Netherlands.
Wang J; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Li W; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Lebre MC; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Beijnen JH; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacology, Universiteitsweg 99, 3584 CG Utrecht, the Netherlands; The Netherlands Cancer Institute, Department of Pharmacy & Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Schinkel AH; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address: .
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Źródło :
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2022 Jan; Vol. 170, pp. 197-207. Date of Electronic Publication: 2021 Dec 21.
Typ publikacji :
Journal Article
MeSH Terms :
Acridines/*pharmacokinetics
Brain/*metabolism
Pyrazoles/*pharmacokinetics
Pyrimidines/*pharmacokinetics
Rifampin/*pharmacokinetics
Ritonavir/*pharmacokinetics
Tetrahydroisoquinolines/*pharmacokinetics
Acridines/administration & dosage ; Administration, Oral ; Animals ; Biological Availability ; Chromatography, Liquid ; Drug Synergism ; Male ; Mice ; Mice, Inbred Strains ; Pyrazoles/administration & dosage ; Pyrimidines/administration & dosage ; Rifampin/administration & dosage ; Ritonavir/administration & dosage ; Tandem Mass Spectrometry ; Tetrahydroisoquinolines/administration & dosage
Czasopismo naukowe
Tytuł :
Development of novel tetrahydroisoquinoline-hydroxamate conjugates as potent dual SERDs/HDAC inhibitors for the treatment of breast cancer.
Autorzy :
Luo G; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: .
Lin X; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Ren S; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Wu S; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Wang X; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Ma L; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Xiang H; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Dec 15; Vol. 226, pp. 113870. Date of Electronic Publication: 2021 Sep 25.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Development*
Antineoplastic Agents/*pharmacology
Breast Neoplasms/*drug therapy
Histone Deacetylase Inhibitors/*pharmacology
Hydroxamic Acids/*pharmacology
Tetrahydroisoquinolines/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Estrogen Receptor alpha/antagonists & inhibitors ; Estrogen Receptor alpha/metabolism ; Female ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Histone Deacetylases/metabolism ; Humans ; Hydroxamic Acids/chemistry ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Structure ; Structure-Activity Relationship ; Tetrahydroisoquinolines/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics.
Autorzy :
Wen WH; State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
Zhang Y; State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
Zhang YY; State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
Yu Q; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Jiang CC; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Tang MC; State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
Pu JY; State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
Wu L; State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
Zhao YL; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Shi T; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China. .
Zhou J; CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. .
Tang GL; State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China. .; School of Chemistry and Material Sciences, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Sub-lane Xiangshan, Hangzhou, 310024, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Dec 06; Vol. 12 (1), pp. 7085. Date of Electronic Publication: 2021 Dec 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biosynthetic Pathways*
Molecular Dynamics Simulation*
Bacteria/*metabolism
Bacterial Proteins/*metabolism
Tetrahydroisoquinolines/*metabolism
Anti-Bacterial Agents/biosynthesis ; Anti-Bacterial Agents/chemistry ; Bacteria/genetics ; Bacterial Proteins/genetics ; Biocatalysis ; Chromatography, High Pressure Liquid ; Drug Resistance, Microbial/genetics ; Humans ; Isoquinolines/chemistry ; Isoquinolines/metabolism ; Mass Spectrometry/methods ; Molecular Structure ; NADP/chemistry ; NADP/metabolism ; Naphthyridines/chemistry ; Naphthyridines/metabolism ; Oxidation-Reduction ; Oxidoreductases/genetics ; Oxidoreductases/metabolism ; Tetrahydroisoquinolines/chemistry
Czasopismo naukowe
Tytuł :
A DNA damage repair gene-associated signature predicts responses of patients with advanced soft-tissue sarcoma to treatment with trabectedin.
Autorzy :
Moura DS; Institute of Biomedicine of Seville (IBIS, HUVR, CSIC, Universidad de Sevilla), Spain.
Peña-Chilet M; Institute of Biomedicine of Seville (IBIS, HUVR, CSIC, Universidad de Sevilla), Spain.; Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, Seville, Spain.; Bioinformatics in Rare Diseases (BiER), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), FPS, Hospital Virgen del Rocio, Seville, Spain.
Cordero Varela JA; Institute of Biomedicine of Seville (IBIS, HUVR, CSIC, Universidad de Sevilla), Spain.
Alvarez-Alegret R; Pathology Department, Miguel Servet University Hospital, Zaragoza, Spain.
Agra-Pujol C; Pathology Department, Gregorio Marañon University Hospital, Madrid, Spain.
Izquierdo F; Pathological Anatomy Service, Complejo Asistencial Universitario de León, Spain.
Ramos R; Pathology Department, Son Espases University Hospital, Mallorca, Spain.
Ortega-Medina L; Pathology Department, Hospital Clinico San Carlos, Madrid, Spain.
Martin-Davila F; Pathology Department, Ciudad Real General Hospital, Spain.
Castilla-Ramirez C; Pathology Department, University Hospital Virgen del Rocio, Seville, Spain.
Hernandez-Leon CN; Pathology Department, Canarias University Hospital, Santa Cruz de Tenerife, Spain.
Romagosa C; Pathology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
Vaz Salgado MA; Medical Oncology Department, Ramon y Cajal University Hospital, Madrid, Spain.
Lavernia J; Medical Oncology Department, Instituto Valenciano de Oncologia, Valencia, Spain.
Bagué S; Pathology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Mayodormo-Aranda E; Pathology Department, Hospital Universitari i Politècnic la Fe, Valencia, Spain.
Vicioso L; Pathology Department, Virgen de la Victoria University Hospital, Malaga, Spain.
Hernández Barceló JE; Pathology Department, Virgen de la Arrixaca University Hospital, Murcia, Spain.
Rubio-Casadevall J; Medical Oncology Department, Hospital Josep Trueta, Catalan Institute of Oncology, Girona, Spain.
de Juan A; Medical Oncology Department, Marqués de Valdecilla University Hospital, Santander, Spain.
Fiaño-Valverde MC; Department of Histopathology, Álvaro Cunqueiro Hospital, University Hospital Complex of Vigo, Spain.
Hindi N; Institute of Biomedicine of Seville (IBIS, HUVR, CSIC, Universidad de Sevilla), Spain.; Medical Oncology Department, University Hospital Fundación Jimenez Diaz, Madrid, Spain.; University Hospital General de Villalba, Madrid, Spain.; Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz (IIS/FJD), Madrid, Spain.
Lopez-Alvarez M; Institute of Biomedicine of Seville (IBIS, HUVR, CSIC, Universidad de Sevilla), Spain.
Lacerenza S; Institute of Biomedicine of Seville (IBIS, HUVR, CSIC, Universidad de Sevilla), Spain.
Dopazo J; Institute of Biomedicine of Seville (IBIS, HUVR, CSIC, Universidad de Sevilla), Spain.; Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, Seville, Spain.; Bioinformatics in Rare Diseases (BiER), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), FPS, Hospital Virgen del Rocio, Seville, Spain.; INB-ELIXIR-es, FPS, Hospital Virgen del Rocío, Seville, Spain.
Gutierrez A; Hematology Department, Son Espases University Hospital, Mallorca, Spain.
Alvarez R; Medical Oncology Department, Gregorio Marañon University Hospital, Madrid, Spain.
Valverde C; Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
Martinez-Trufero J; Medical Oncology Department, Miguel Servet University Hospital, Zaragoza, Spain.
Martín-Broto J; Institute of Biomedicine of Seville (IBIS, HUVR, CSIC, Universidad de Sevilla), Spain.; Medical Oncology Department, University Hospital Fundación Jimenez Diaz, Madrid, Spain.; University Hospital General de Villalba, Madrid, Spain.; Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz (IIS/FJD), Madrid, Spain.
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Źródło :
Molecular oncology [Mol Oncol] 2021 Dec; Vol. 15 (12), pp. 3691-3705. Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Sarcoma*/drug therapy
Sarcoma*/genetics
Tetrahydroisoquinolines*/adverse effects
Antineoplastic Agents, Alkylating/pharmacology ; Antineoplastic Agents, Alkylating/therapeutic use ; DNA Damage ; DNA Repair/genetics ; Dioxoles/adverse effects ; Humans ; Retrospective Studies ; Trabectedin/therapeutic use
Czasopismo naukowe
Tytuł :
Intranasal administration of dauricine loaded on graphene oxide: multi-target therapy for Alzheimer's disease.
Autorzy :
Wang K; School of Pharmacy, Guilin Medical University, Guilin, China.
Wang L; School of Pharmacy, Zhejiang Chinese Medical University, Zhejiang, China.
Chen L; School of Pharmacy, Guilin Medical University, Guilin, China.
Peng C; School of Pharmacy, Guilin Medical University, Guilin, China.
Luo B; School of Pharmacy, Guilin Medical University, Guilin, China.
Mo J; Department of Pharmacy, Affiliated Hospital of Guilin Medical University, Guilin, China.
Chen W; Department of Pharmacy, Affiliated Hospital of Guilin Medical University, Guilin, China.
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Źródło :
Drug delivery [Drug Deliv] 2021 Dec; Vol. 28 (1), pp. 580-593.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*drug therapy
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Benzylisoquinolines/*pharmacology
Drug Carriers/*chemistry
Nanoparticles/*chemistry
Tetrahydroisoquinolines/*pharmacology
Administration, Intranasal ; Amyloid beta-Peptides/drug effects ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Benzylisoquinolines/administration & dosage ; Cell Line ; Chemistry, Pharmaceutical ; Disease Models, Animal ; Graphite/chemistry ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Neuroglia/drug effects ; Oxidative Stress/drug effects ; Particle Size ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/biosynthesis ; Surface Properties ; Tetrahydroisoquinolines/administration & dosage
Czasopismo naukowe

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