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Tytuł:
Exploration of Tetrahydroisoquinoline- and Benzo[ c ]azepine-Based Sphingosine 1-Phosphate Receptor 1 Agonists for the Treatment of Multiple Sclerosis.
Autorzy:
Cha E; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.; Department of Chemistry, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
Kim J; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
Gotina L; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.
Kim J; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.
Kim HJ; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
Seo SH; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.
Park JE; New Drug Development Center, Daegu Gyeongbuk Medical Innovation Foundation, 80 Cheombok-ro, Dong-gu, Daegu 41061, Republic of Korea.
Joo J; New Drug Development Center, Daegu Gyeongbuk Medical Innovation Foundation, 80 Cheombok-ro, Dong-gu, Daegu 41061, Republic of Korea.
Kang M; Doping Control Center, Research Resources Division, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.
Lee J; Doping Control Center, Research Resources Division, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.
Hwang H; New Drug Development Center, Daegu Gyeongbuk Medical Innovation Foundation, 80 Cheombok-ro, Dong-gu, Daegu 41061, Republic of Korea.
Kim HJ; Department of Chemistry, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
Pae AN; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.
Park KD; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.
Park JH; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.
Lim SM; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2023 Aug 10; Vol. 66 (15), pp. 10381-10412. Date of Electronic Publication: 2023 Jul 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Multiple Sclerosis*/drug therapy
Multiple Sclerosis*/metabolism
Tetrahydroisoquinolines*/therapeutic use
Humans ; Sphingosine-1-Phosphate Receptors ; Bradycardia/chemically induced ; Receptors, Lysosphingolipid/agonists ; Receptors, Lysosphingolipid/metabolism ; Receptors, Lysosphingolipid/therapeutic use ; Fingolimod Hydrochloride/pharmacology ; Fingolimod Hydrochloride/therapeutic use ; Sphingosine/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Recent Advances in the Total Synthesis of the Tetrahydroisoquinoline Alkaloids (2002-2020).
Autorzy:
Kim AN; The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Ngamnithiporn A; Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Road, Bangkok 10210, Thailand.
Du E; The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Stoltz BM; The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
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Źródło:
Chemical reviews [Chem Rev] 2023 Aug 09; Vol. 123 (15), pp. 9447-9496. Date of Electronic Publication: 2023 Jul 10.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Alkaloids*/chemistry
Tetrahydroisoquinolines*/chemistry
Biological Products*/chemistry
Czasopismo naukowe
Szczegóły
Tytuł:
Synthesis and biological evaluation of atropisomeric tetrahydroisoquinolines overcoming docetaxel resistance in triple-negative human breast cancer cells.
Autorzy:
Song J; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: .
Kim A; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Hong I; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Kim S; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Byun WS; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Lee HS; Department of Chemistry, Sogang University, Seoul 04107, Republic of Korea.
Kim HS; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Lee SK; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: .
Kwon Y; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2023 Aug; Vol. 137, pp. 106573. Date of Electronic Publication: 2023 Apr 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tetrahydroisoquinolines*
Triple Negative Breast Neoplasms*/drug therapy
Triple Negative Breast Neoplasms*/metabolism
Humans ; Docetaxel/pharmacology ; Apoptosis ; Cell Line, Tumor
Czasopismo naukowe
Szczegóły
Tytuł:
Progress in the Total Synthesis of Antitumor Tetrahydroisoquinoline Alkaloids.
Autorzy:
Gao Y; Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205, China.
Tu N; Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205, China.
Liu X; Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205, China.
Lu K; Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205, China.
Chen S; Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205, China.
Guo J; Department Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, 430205, China.
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Źródło:
Chemistry & biodiversity [Chem Biodivers] 2023 May; Vol. 20 (5), pp. e202300172. Date of Electronic Publication: 2023 Apr 04.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Tetrahydroisoquinolines*/pharmacology
Tetrahydroisoquinolines*/chemistry
Alkaloids*/chemistry
Biological Products*/chemistry
Czasopismo naukowe
Szczegóły
Tytuł:
Structural optimization of tetrahydroisoquinoline-hydroxamate hybrids as potent dual ERα degraders and HDAC inhibitors.
Autorzy:
Xiong S; State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Wang X; State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Zhu M; State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Song K; State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Li Y; State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Yang J; State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Liu X; State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Liu M; State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Dong H; The Public Laboratory Platform, China Pharmaceutical University, Nanjing 210009, China.
Chen M; State Key Laboratory of Natural Medicines, National R&D Center for Chinese Herbal Medicine Processing, College of Engineering, China Pharmaceutical University, Nanjing 211109, China.
Chen D; Department of Analytical Chemistry, School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China.
Xiang H; State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: .
Luo G; State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2023 May; Vol. 134, pp. 106459. Date of Electronic Publication: 2023 Mar 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Breast Neoplasms*/drug therapy
Tetrahydroisoquinolines*/pharmacology
Antineoplastic Agents*/chemistry
Humans ; Female ; Histone Deacetylase Inhibitors/chemistry ; Estrogen Receptor alpha/metabolism ; Histone Deacetylases/metabolism ; Hydroxamic Acids/pharmacology ; Cell Proliferation ; Structure-Activity Relationship ; Cell Line, Tumor
Czasopismo naukowe
Szczegóły
Tytuł:
Matrix-Metalloproteinase Inhibitory Study of Novel Tetrahydroisoquinoline-4-carboxylates: Design, Synthesis, and Molecular Docking Studies.
Autorzy:
Devappa Satyanarayan N; Department of Pharmaceutical Chemistry, Kuvempu University, Post Graduate Center, Kadur, Chikkamagaluru, Karnataka 577548, India.
Kammathalli Siddappa M; Department of Pharmaceutical Chemistry, Kuvempu University, Post Graduate Center, Kadur, Chikkamagaluru, Karnataka 577548, India.
Rahman A; Department of Pharmaceutical Chemistry, Kuvempu University, Post Graduate Center, Kadur, Chikkamagaluru, Karnataka 577548, India.
Belur Ningegowda N; Department of Pharmaceutical Chemistry, Kuvempu University, Post Graduate Center, Kadur, Chikkamagaluru, Karnataka 577548, India.
Sherapura A; Molecular Biomedicine Laboratory, Post Graduate Department of Studies and Research in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Shivamogga, Karnataka, 577203, India.
Siddesh BM; Molecular Biomedicine Laboratory, Post Graduate Department of Studies and Research in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Shivamogga, Karnataka, 577203, India.
Prabhakar BT; Molecular Biomedicine Laboratory, Post Graduate Department of Studies and Research in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Shivamogga, Karnataka, 577203, India.
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Źródło:
Chemistry & biodiversity [Chem Biodivers] 2023 May; Vol. 20 (5), pp. e202201152. Date of Electronic Publication: 2023 Apr 27.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Tetrahydroisoquinolines*/pharmacology
Animals ; Mice ; Molecular Structure ; Molecular Docking Simulation ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Structure-Activity Relationship ; Metalloproteases/pharmacology ; Drug Design ; Protein Kinase Inhibitors/pharmacology
Czasopismo naukowe
Szczegóły
Tytuł:
Synthesis of Novel 1-Oxo-2,3,4-trisubstituted Tetrahydroisoquinoline Derivatives, Bearing Other Heterocyclic Moieties and Comparative Preliminary Study of Anti-Coronavirus Activity of Selected Compounds.
Autorzy:
Kandinska MI; Faculty of Chemistry and Pharmacy, University of Sofia St. Kliment Ohridski, 1 J. Bourchier Avenue, 1164 Sofia, Bulgaria.
Burdzhiev NT; Faculty of Chemistry and Pharmacy, University of Sofia St. Kliment Ohridski, 1 J. Bourchier Avenue, 1164 Sofia, Bulgaria.
Cheshmedzhieva DV; Faculty of Chemistry and Pharmacy, University of Sofia St. Kliment Ohridski, 1 J. Bourchier Avenue, 1164 Sofia, Bulgaria.
Ilieva SV; Faculty of Chemistry and Pharmacy, University of Sofia St. Kliment Ohridski, 1 J. Bourchier Avenue, 1164 Sofia, Bulgaria.
Grozdanov PP; Bulgarian Academy of Sciences, The Stephan Angeloff Institute of Microbiology, 26 Georgi Bonchev Street, 1113 Sofia, Bulgaria.
Vilhelmova-Ilieva N; Bulgarian Academy of Sciences, The Stephan Angeloff Institute of Microbiology, 26 Georgi Bonchev Street, 1113 Sofia, Bulgaria.
Nikolova N; Bulgarian Academy of Sciences, The Stephan Angeloff Institute of Microbiology, 26 Georgi Bonchev Street, 1113 Sofia, Bulgaria.
Lozanova VV; Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University-Sofia, 2 Zdrave Street, 1431 Sofia, Bulgaria.
Nikolova I; Bulgarian Academy of Sciences, The Stephan Angeloff Institute of Microbiology, 26 Georgi Bonchev Street, 1113 Sofia, Bulgaria.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Feb 03; Vol. 28 (3). Date of Electronic Publication: 2023 Feb 03.
Typ publikacji:
Journal Article
MeSH Terms:
Coronavirus*
Coronavirus Infections*
Coronavirus 229E, Human*
Tetrahydroisoquinolines*/pharmacology
Humans ; Antiviral Agents/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Enantiodivergent Synthesis of 1-Heteroaryl Tetrahydroisoquinolines Catalyzed by Imine Reductases.
Autorzy:
Liu T; Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China.; National Center of Technology Innovation for Synthetic Biology, National Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 Xi Qi Dao, Tianjin Airport Economic Area, Tianjin 300308, China.
Xu Z; National Center of Technology Innovation for Synthetic Biology, National Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 Xi Qi Dao, Tianjin Airport Economic Area, Tianjin 300308, China.
Feng J; National Center of Technology Innovation for Synthetic Biology, National Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 Xi Qi Dao, Tianjin Airport Economic Area, Tianjin 300308, China.
Yu S; National Center of Technology Innovation for Synthetic Biology, National Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 Xi Qi Dao, Tianjin Airport Economic Area, Tianjin 300308, China.
Wang M; Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China.
Yao P; National Center of Technology Innovation for Synthetic Biology, National Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 Xi Qi Dao, Tianjin Airport Economic Area, Tianjin 300308, China.
Wu Q; National Center of Technology Innovation for Synthetic Biology, National Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 Xi Qi Dao, Tianjin Airport Economic Area, Tianjin 300308, China.
Zhu D; National Center of Technology Innovation for Synthetic Biology, National Engineering Research Center of Industrial Enzymes and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 Xi Qi Dao, Tianjin Airport Economic Area, Tianjin 300308, China.
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Źródło:
Organic letters [Org Lett] 2023 Apr 14; Vol. 25 (14), pp. 2438-2443. Date of Electronic Publication: 2023 Apr 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Oxidoreductases*/metabolism
Tetrahydroisoquinolines*
Biocatalysis ; Imines ; Stereoisomerism
Czasopismo naukowe
Szczegóły
Tytuł:
Design and evaluation of dibenzoazepine-tetrahydroisoquinoline hybrids as potential P-glycoprotein inhibitors against multidrug resistant K562/A02 cells.
Autorzy:
Jiang C; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, People's Republic of China.
Pan T; Blood Diseases Institute, Xuzhou Medical University, Xuzhou, 221004, People's Republic of China.
Jiang Y; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, People's Republic of China.
Zhang Z; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, People's Republic of China.
Zeng M; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, People's Republic of China.
Sun S; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, People's Republic of China.
Li Z; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, People's Republic of China.
Wu Y; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, People's Republic of China.
Qiu J; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, People's Republic of China.
Niu M; Blood Diseases Institute, Xuzhou Medical University, Xuzhou, 221004, People's Republic of China; Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221004, People's Republic of China. Electronic address: .
Gu X; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, People's Republic of China. Electronic address: gu_.
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Mar 05; Vol. 249, pp. 115150. Date of Electronic Publication: 2023 Jan 25.
Typ publikacji:
Journal Article
MeSH Terms:
Doxorubicin*/pharmacology
Tetrahydroisoquinolines*/pharmacology
Humans ; K562 Cells ; Molecular Docking Simulation ; Drug Resistance, Neoplasm ; ATP Binding Cassette Transporter, Subfamily B, Member 1 ; ATP Binding Cassette Transporter, Subfamily B/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Trabectedin use in soft-tissue sarcoma patients in a real-world setting: Data from an Italian national drug-access registry.
Autorzy:
Vincenzi B; University Campus Bio-Medico, Rome, Italy.
Napolitano A; University Campus Bio-Medico, Rome, Italy.; Royal Marsden NHS Foundation Trust, London, UK.
Comandone A; Humanitas Gradenigo Hospital, Turin, Italy.
Sanfilippo R; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Celant S; Italian Medicines Agency, Rome, Italy.
Olimpieri PP; Italian Medicines Agency, Rome, Italy.
Di Segni S; Italian Medicines Agency, Rome, Italy.
Russo P; Italian Medicines Agency, Rome, Italy.
Casali PG; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.; University of Milan, Milan, Italy.
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Źródło:
International journal of cancer [Int J Cancer] 2023 Feb 15; Vol. 152 (4), pp. 761-768. Date of Electronic Publication: 2022 Oct 13.
Typ publikacji:
Journal Article
MeSH Terms:
Leiomyosarcoma*/pathology
Tetrahydroisoquinolines*/therapeutic use
Sarcoma*/drug therapy
Sarcoma*/pathology
Liposarcoma, Myxoid*/drug therapy
Soft Tissue Neoplasms*/drug therapy
Humans ; Adult ; Female ; Male ; Trabectedin/adverse effects ; Antineoplastic Agents, Alkylating/therapeutic use ; Dioxoles/therapeutic use ; Registries
Czasopismo naukowe
Szczegóły
Tytuł:
Novel Tetrahydroisoquinoline-Based Heterocyclic Compounds Efficiently Inhibit SARS-CoV-2 Infection In Vitro .
Autorzy:
Wang X; Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Burdzhiev NT; Faculty of Chemistry and Pharmacy, Sofia University 'St. Kliment Ohridski', 1, James Bourchier Avenue, 1164 Sofia, Bulgaria.
Hu H; Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Li Y; Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Li J; Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Lozanova VV; Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University-Sofia, 2 Zdrave Str., 1431 Sofia, Bulgaria.
Kandinska MI; Faculty of Chemistry and Pharmacy, Sofia University 'St. Kliment Ohridski', 1, James Bourchier Avenue, 1164 Sofia, Bulgaria.
Wang M; Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.; Hubei Jiangxia Laboratory, Wuhan 430071, China.
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Źródło:
Viruses [Viruses] 2023 Feb 11; Vol. 15 (2). Date of Electronic Publication: 2023 Feb 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19*
Heterocyclic Compounds*
Tetrahydroisoquinolines*/pharmacology
Humans ; SARS-CoV-2 ; Pandemics ; Chloroquine/pharmacology ; Hydroxychloroquine/pharmacology ; Antiviral Agents/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, synthesis, and biological evaluation of tetrahydroisoquinoline stilbene derivatives as potential antitumor candidates.
Autorzy:
Li B; Department of Chemistry, Bengbu Medical College, Bengbu, China.
Wang J; Department of Chemistry, Bengbu Medical College, Bengbu, China.
Yuan M; Department of Chemistry, Bengbu Medical College, Bengbu, China.
Miao Y; Department of Chemistry, Bengbu Medical College, Bengbu, China.
Zhang H; Department of Chemistry, Bengbu Medical College, Bengbu, China.
Zhang J; Department of Chemistry, Bengbu Medical College, Bengbu, China.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2023 Feb; Vol. 101 (2), pp. 364-379. Date of Electronic Publication: 2022 Sep 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Stilbenes*/pharmacology
Antineoplastic Agents*/pharmacology
Tetrahydroisoquinolines*/pharmacology
Humans ; Cell Line, Tumor ; Tubulin/metabolism ; Tubulin Modulators/pharmacology ; Apoptosis ; Drug Screening Assays, Antitumor ; Cell Proliferation ; Structure-Activity Relationship
Czasopismo naukowe
Szczegóły
Tytuł:
Design, Synthesis, and Antimycobacterial Evaluation of Novel Tetrahydroisoquinoline Hydrazide Analogs.
Autorzy:
Kumar BVS; Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad, 500078, Telangana, India.
Khetmalis YM; Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad, 500078, Telangana, India.
Nandikolla A; Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad, 500078, Telangana, India.
Kumar BK; Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science, Pilani Campus, Pilani, 333031, Rajasthan, India.
Van Calster K; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), S7, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Belgium.
Murugesan S; Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science, Pilani Campus, Pilani, 333031, Rajasthan, India.
Cappoen D; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), S7, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Belgium.
Sekhar KVGC; Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad, 500078, Telangana, India.
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Źródło:
Chemistry & biodiversity [Chem Biodivers] 2023 Feb; Vol. 20 (2), pp. e202200939. Date of Electronic Publication: 2023 Jan 16.
Typ publikacji:
Journal Article
MeSH Terms:
Mycobacterium tuberculosis*
Tetrahydroisoquinolines*
Antitubercular Agents/pharmacology ; Molecular Docking Simulation ; Structure-Activity Relationship ; Hydrazines ; Microbial Sensitivity Tests ; Bacterial Proteins/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Evaluation of the Local Anesthetic Activity, Acute Toxicity, and Structure-Toxicity Relationship in Series of Synthesized 1-Aryltetrahydroisoquinoline Alkaloid Derivatives In Vivo and In Silico.
Autorzy:
Azamatov AA; Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Mirzo Ulugbek Str. 77, Tashkent 100170, Uzbekistan.
Zhurakulov SN; Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Mirzo Ulugbek Str. 77, Tashkent 100170, Uzbekistan.; Department of Organic Chemistry, Faculty of Chemistry, National University of Uzbekistan Named after Mirzo Ulugbek, University Str. 4, Tashkent 100174, Uzbekistan.
Vinogradova VI; Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Mirzo Ulugbek Str. 77, Tashkent 100170, Uzbekistan.
Tursunkhodzhaeva F; Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Mirzo Ulugbek Str. 77, Tashkent 100170, Uzbekistan.
Khinkar RM; Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Malatani RT; Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Aldurdunji MM; Department of Clinical Pharmacy, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Tiezzi A; Department for the Innovation in Biological, Agro-Food and Forestal Systems, Tuscia University, 01100 Viterbo, Italy.
Mamadalieva NZ; Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Mirzo Ulugbek Str. 77, Tashkent 100170, Uzbekistan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jan 04; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 04.
Typ publikacji:
Journal Article
MeSH Terms:
Tetrahydroisoquinolines*/toxicity
Tetrahydroisoquinolines*/chemistry
Alkaloids*/toxicity
Mice ; Animals ; Rabbits ; Anesthetics, Local ; Anesthesia, Local ; Lethal Dose 50
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Quantitative Determination of Endogenous Tetrahydroisoquinolines, Potential Parkinson's Disease Biomarkers, in Mammals.
Autorzy:
Hényková E; Laboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences & Palacký University, Šlechtitelů 27, 783 71 Olomouc, Czech Republic.; Department of Neurology, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, I. P. Pavlova 6, 779 00 Olomouc, Czech Republic.
Kaleta M; Laboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences & Palacký University, Šlechtitelů 27, 783 71 Olomouc, Czech Republic.; Department of Neurology, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, I. P. Pavlova 6, 779 00 Olomouc, Czech Republic.
Klíčová K; Department of Neurology, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, I. P. Pavlova 6, 779 00 Olomouc, Czech Republic.
Gonzalez G; Department of Neurology, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, I. P. Pavlova 6, 779 00 Olomouc, Czech Republic.; Department of Experimental Biology, Faculty of Science, Palacky University Olomouc, Šlechtitelů 27, 783 71 Olomouc, Czech Republic.
Novák O; Laboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences & Palacký University, Šlechtitelů 27, 783 71 Olomouc, Czech Republic.
Strnad M; Laboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences & Palacký University, Šlechtitelů 27, 783 71 Olomouc, Czech Republic.; Department of Neurology, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, I. P. Pavlova 6, 779 00 Olomouc, Czech Republic.
Kaňovský P; Department of Neurology, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, I. P. Pavlova 6, 779 00 Olomouc, Czech Republic.
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Źródło:
ACS chemical neuroscience [ACS Chem Neurosci] 2022 Dec 07; Vol. 13 (23), pp. 3230-3246. Date of Electronic Publication: 2022 Nov 14.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Parkinson Disease*/diagnosis
Tetrahydroisoquinolines*/analysis
Humans ; Biomarkers
Czasopismo naukowe
Szczegóły
Tytuł:
Simplified hybrids of two anticancer bistetrahydroisoquinoline alkaloids ecteinascidin 743 and cribrostatin 4 and inhibitory activity against proliferation of cancer cells.
Autorzy:
Wang M; State Key Laboratory of Coordination Chemistry, and Jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China. .
Yu BB; State Key Laboratory of Coordination Chemistry, and Jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China. .
Yao ZJ; State Key Laboratory of Coordination Chemistry, and Jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China. .
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Źródło:
Organic & biomolecular chemistry [Org Biomol Chem] 2022 Nov 09; Vol. 20 (43), pp. 8438-8442. Date of Electronic Publication: 2022 Nov 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tetrahydroisoquinolines*/pharmacology
Tetrahydroisoquinolines*/chemistry
Alkaloids*/pharmacology
Alkaloids*/chemistry
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Neoplasms*
Trabectedin/pharmacology ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Structure-Activity Relationship ; Cell Line, Tumor ; Molecular Structure ; Dose-Response Relationship, Drug
Czasopismo naukowe
Szczegóły
Tytuł:
Transformation of Renieramycin M into Renieramycins T and S by Intramolecular Photoredox Reaction of 7-Methoxy-6-methyl-1,2,3,4-tetrahydroisoquinoline-5,8-dione Derivatives.
Autorzy:
Yokoya M; Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
Yamazaki-Nakai M; Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
Nakai K; Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
Sirimangkalakitti N; Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
Chamni S; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Suwanborirux K; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Saito N; Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
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Źródło:
Journal of natural products [J Nat Prod] 2023 Jan 27; Vol. 86 (1), pp. 222-231. Date of Electronic Publication: 2023 Jan 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tetrahydroisoquinolines*
Biological Products*
Dioxoles
Czasopismo naukowe
Szczegóły
Tytuł:
Identification of N- and C-3-Modified Laudanosoline Derivatives as Novel Influenza PA N Endonuclease Inhibitors.
Autorzy:
Liao Y; Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Ye Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Liu M; Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Liu Z; Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Wang J; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Li B; Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Huo L; Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Zhuang Y; Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Chen L; Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Chen J; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Gao Y; Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Ning X; Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Li S; College of Basic Medicine and Public Hygiene, Jinan University, Guangzhou 510632, China.
Liu S; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.; State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Southern Medical University, Guangzhou 510515, China.
Song G; Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2023 Jan 12; Vol. 66 (1), pp. 188-219. Date of Electronic Publication: 2022 Dec 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Influenza, Human*
Orthomyxoviridae*
Tetrahydroisoquinolines*/pharmacology
Animals ; Mice ; Humans ; Antiviral Agents/pharmacology ; Antiviral Agents/metabolism ; Endonucleases
Czasopismo naukowe
Szczegóły
Tytuł:
Non-covalent interactions in the monohydrated complexes of 1,2,3,4-tetrahydroisoquinoline.
Autorzy:
Das S; Department of Physics, Government General Degree College, Hooghly, Singur, 712409, India.; Department of Physics, The University of Burdwan, Golapbag Campus, Burdwan, 713104, West Bengal, India.
Chakraborty A; Department of Physics, The University of Burdwan, Golapbag Campus, Burdwan, 713104, West Bengal, India. .
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Źródło:
Journal of molecular modeling [J Mol Model] 2023 Jan 11; Vol. 29 (2), pp. 37. Date of Electronic Publication: 2023 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Tetrahydroisoquinolines*
Hydrogen Bonding
Czasopismo naukowe
Szczegóły
Tytuł:
Selective oxidative β-C-H bond sulfenylation of tetrahydroisoquinolines with elemental sulfur.
Autorzy:
Guo T; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P. R. China. .
Bi L; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P. R. China. .
Shen L; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P. R. China. .
Wei Q; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P. R. China. .
Zhu C; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P. R. China. .
Zhang P; Green Catalysis Center, College of Chemistry, Henan Advanced Institute of Technology, Zhengzhou University, Zhengzhou 450001, PR China. .
Zhao Y; School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, P. R. China. zhao_.
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Źródło:
Organic & biomolecular chemistry [Org Biomol Chem] 2022 Dec 21; Vol. 21 (1), pp. 127-131. Date of Electronic Publication: 2022 Dec 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tetrahydroisoquinolines*/chemistry
Molecular Structure ; Sulfur/chemistry ; Oxidation-Reduction ; Oxidative Stress
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 3737

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