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Tytuł :
Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1 H -tetrazols as novel microtubule destabilizers.
Autorzy :
Wang C; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Li Y; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Liu Z; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China.
Wang Z; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China.
Liu Z; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Man S; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China.
Zhang Y; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Bao K; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China.
Wu Y; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China.
Guan Q; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Zuo D; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China.
Zhang W; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 549-560.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Microtubules/*drug effects
Tetrazoles/*pharmacology
Tubulin Modulators/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Microtubules/metabolism ; Microwaves ; Models, Molecular ; Molecular Structure ; Polymerization/drug effects ; Structure-Activity Relationship ; Tetrazoles/chemical synthesis ; Tetrazoles/chemistry ; Tubulin/metabolism ; Tubulin Modulators/chemical synthesis ; Tubulin Modulators/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Optimization and SAR research at the piperazine and phenyl rings of JNJ4796 as new anti-influenza A virus agents, part 1.
Autorzy :
Wang A; CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Department of Pharmaceutical Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, China.
Li Y; CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Lv K; CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: .
Gao R; CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Wang A; CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Yan H; CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Qin X; CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Xu S; CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Ma C; CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Jiang J; CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Wei Z; Chemical Medicine Department, R&D Center, Tasly Pharmaceutical Group Co. Ltd., Tianjin, 300410, China.
Zhang K; Department of Pharmaceutical Chemistry, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, China. Electronic address: .
Liu M; CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113591. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
Influenza A Virus, H1N1 Subtype/*drug effects
Piperazine/*pharmacology
Piperazines/*pharmacology
Pyridines/*pharmacology
Tetrazoles/*pharmacology
Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Molecular Structure ; Piperazine/chemical synthesis ; Piperazine/chemistry ; Piperazines/chemical synthesis ; Piperazines/chemistry ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Structure-Activity Relationship ; Tetrazoles/chemical synthesis ; Tetrazoles/chemistry
Czasopismo naukowe
Tytuł :
Dissipation and Distribution of Picarbutrazox Residue Following Spraying with an Unmanned Aerial Vehicle on Chinese Cabbage ( Brassica campestris var. pekinensis ).
Autorzy :
Kim CJ; Residual Agrochemical Assessment Division, Department of Agro-Food Safety and Crop Protection, National Institute of Agricultural Sciences, Wanju 55365, Korea.
Jeong WT; Residual Agrochemical Assessment Division, Department of Agro-Food Safety and Crop Protection, National Institute of Agricultural Sciences, Wanju 55365, Korea.
Kyung KS; Department of Environmental and Biological Chemistry, College of Agriculture, Life and Environment Science, Chungbuk National University, Cheongju 28644, Korea.
Lee HD; Residual Agrochemical Assessment Division, Department of Agro-Food Safety and Crop Protection, National Institute of Agricultural Sciences, Wanju 55365, Korea.
Kim D; Residual Agrochemical Assessment Division, Department of Agro-Food Safety and Crop Protection, National Institute of Agricultural Sciences, Wanju 55365, Korea.
Song HS; Disaster Prevention Engineering Division, Department of Agricultural Engineering, National Institute of Agricultural Science, Wanju 55365, Korea.
Kang Y; Disaster Prevention Engineering Division, Department of Agricultural Engineering, National Institute of Agricultural Science, Wanju 55365, Korea.; Upland Mechanization Team, Department of Agricultural Engineering, National Institute of Agricultural Science, Wanju 55365, Korea.
Noh HH; Residual Agrochemical Assessment Division, Department of Agro-Food Safety and Crop Protection, National Institute of Agricultural Sciences, Wanju 55365, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Sep 18; Vol. 26 (18). Date of Electronic Publication: 2021 Sep 18.
Typ publikacji :
Journal Article
MeSH Terms :
Brassica*
Tetrazoles*
Chromatography, Liquid ; Pesticide Residues
Czasopismo naukowe
Tytuł :
Alkylation of 5-Substituted 1 H -Tetrazoles via the Diazotization of Aliphatic Amines.
Autorzy :
Reynard G; Département de Chimie, Center for Green Chemistry and Catalysis, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, Québec, Canada H3C 3J7.
Lebel H; Département de Chimie, Center for Green Chemistry and Catalysis, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, Québec, Canada H3C 3J7.
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Źródło :
The Journal of organic chemistry [J Org Chem] 2021 Sep 03; Vol. 86 (17), pp. 12452-12459. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amines*
Tetrazoles*
Alkylation ; Nitriles
Czasopismo naukowe
Tytuł :
Development of hybrid spectrofluorimetric method for simultaneous determination of Valsartan and Sacubitril in LCZ696 tablets.
Autorzy :
Youssef RM; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt. Electronic address: .
El-Nahass SA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt.
Soliman SA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt.
Younis SE; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt.
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Źródło :
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2021 Jul 15; Vol. 256, pp. 119748. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article
MeSH Terms :
Aminobutyrates*
Tetrazoles*
Drug Combinations ; Humans ; Spectrometry, Fluorescence ; Tablets ; Valsartan
Czasopismo naukowe
Tytuł :
Efficacy and safety of cenobamate in patients with uncontrolled focal seizures: A meta-analysis.
Autorzy :
Zhang L; Department of Pediatrics, Yancheng Maternal and Children's Health Hospital, Yancheng, China.
Wang J; Department of Pediatrics, Yancheng Maternal and Children's Health Hospital, Yancheng, China.
Wang C; Department of Pediatrics, Yancheng Maternal and Children's Health Hospital, Yancheng, China.
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Źródło :
Acta neurologica Scandinavica [Acta Neurol Scand] 2021 Jul; Vol. 144 (1), pp. 58-66. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Anticonvulsants/*administration & dosage
Carbamates/*administration & dosage
Chlorophenols/*administration & dosage
Drug Resistant Epilepsy/*drug therapy
Seizures/*drug therapy
Tetrazoles/*administration & dosage
Anticonvulsants/adverse effects ; Carbamates/adverse effects ; Chlorophenols/adverse effects ; Dizziness/chemically induced ; Dose-Response Relationship, Drug ; Drug Resistant Epilepsy/diagnosis ; Fatigue/chemically induced ; Humans ; Nausea/chemically induced ; Randomized Controlled Trials as Topic/methods ; Seizures/diagnosis ; Tetrazoles/adverse effects ; Treatment Outcome ; Vertigo/chemically induced
Czasopismo naukowe
Tytuł :
Explanation of the Formation of Complexes between Representatives of Oxazolidinones and HDAS-β-CD Using Molecular Modeling as a Complementary Technique to cEKC and NMR.
Autorzy :
Bocian W; Falsified Medicines and Medical Devices Department, National Medicines Institute, Chełmska 30/34, 00-725 Warsaw, Poland.
Bednarek E; Falsified Medicines and Medical Devices Department, National Medicines Institute, Chełmska 30/34, 00-725 Warsaw, Poland.
Michalska K; Department of Synthetic Drugs, National Medicines Institute, Chełmska 30/34, 00-725 Warsaw, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 01; Vol. 22 (13). Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article
MeSH Terms :
Oxazolidinones/*chemistry
Tetrazoles/*chemistry
beta-Cyclodextrins/*chemistry
Cyclodextrins/chemistry ; Electrophoresis, Capillary/methods ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy/methods ; Models, Molecular ; Oxazolidinones/metabolism ; Stereoisomerism ; Tetrazoles/metabolism
Czasopismo naukowe
Tytuł :
UPLC-MS/MS assay of Tedizolid in rabbit aqueous humor: Application to ocular pharmacokinetic study.
Autorzy :
Kalam MA; Nanobiotechnology Unit, Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Iqbal M; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; Bioavailability Unit, Central Lab, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Alshememry A; Nanobiotechnology Unit, Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Alkholief M; Nanobiotechnology Unit, Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Alshamsan A; Nanobiotechnology Unit, Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. Electronic address: .
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Źródło :
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2021 May 01; Vol. 1171, pp. 122621. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article
MeSH Terms :
Aqueous Humor/*chemistry
Chromatography, High Pressure Liquid/*methods
Oxazolidinones/*analysis
Oxazolidinones/*pharmacokinetics
Tandem Mass Spectrometry/*methods
Tetrazoles/*analysis
Tetrazoles/*pharmacokinetics
Animals ; Limit of Detection ; Linear Models ; Ophthalmic Solutions ; Oxazolidinones/chemistry ; Rabbits ; Reproducibility of Results ; Tetrazoles/chemistry
Czasopismo naukowe
Tytuł :
Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor.
Autorzy :
Smolinski MP; Athenex Inc., Conventus Building, 1001 Main Street, Suite 600, Buffalo, New York 14203, United States.
Urgaonkar S; Athenex Inc., Conventus Building, 1001 Main Street, Suite 600, Buffalo, New York 14203, United States.
Pitzonka L; Athenex Inc., Conventus Building, 1001 Main Street, Suite 600, Buffalo, New York 14203, United States.
Cutler M; Athenex Inc., Conventus Building, 1001 Main Street, Suite 600, Buffalo, New York 14203, United States.
Lee G; Hanmi Pharmaceutical Co. Ltd., 14, Wiryeseong-daero, Songpa-gu, Seoul, 05545, Korea.
Suh KH; Hanmi Pharmaceutical Co. Ltd., 14, Wiryeseong-daero, Songpa-gu, Seoul, 05545, Korea.
Lau JYN; Athenex Inc., Conventus Building, 1001 Main Street, Suite 600, Buffalo, New York 14203, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 3677-3693. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily B/*antagonists & inhibitors
Tetrazoles/*pharmacology
Administration, Oral ; Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/pharmacology ; Drug Discovery ; Humans ; Intestinal Mucosa/drug effects ; Molecular Structure ; Paclitaxel/administration & dosage ; Paclitaxel/pharmacology ; Structure-Activity Relationship ; Tetrazoles/chemical synthesis ; Tetrazoles/metabolism
Czasopismo naukowe
Tytuł :
Cilostazol for intermittent claudication.
Autorzy :
Brown T; Cochrane Vascular, University of Edinburgh, Edinburgh, UK.
Forster RB; Department of Health Registry Research and Development, Norwegian Institute of Public Health, Bergen, Norway.
Cleanthis M; Frimley Park Hospital NHS Foundation Trust, Surrey, UK.
Mikhailidis DP; Department of Clinical Biochemistry, Royal Free Hospital Campus, University College London Medical School, London, UK.
Stansby G; Northern Vascular Centre, Freeman Hospital, Newcastle, UK.
Stewart M; Cochrane Vascular, University of Edinburgh, Edinburgh, UK.; Usher Institute, University of Edinburgh, Edinburgh, UK.
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Źródło :
The Cochrane database of systematic reviews [Cochrane Database Syst Rev] 2021 Jun 30; Vol. 6. Cochrane AN: CD003748. Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms :
Cilostazol/*therapeutic use
Intermittent Claudication/*drug therapy
Platelet Aggregation Inhibitors/*therapeutic use
Tetrazoles/*therapeutic use
Aged ; Bias ; Humans ; Intermittent Claudication/etiology ; Middle Aged ; Myocardial Infarction/prevention & control ; Pentoxifylline/therapeutic use ; Peripheral Vascular Diseases/complications ; Peripheral Vascular Diseases/drug therapy ; Placebos/therapeutic use ; Platelet Aggregation Inhibitors/adverse effects ; Randomized Controlled Trials as Topic ; Stroke/prevention & control ; Tetrazoles/adverse effects ; Walking
Czasopismo naukowe
Tytuł :
Secondary Effects of Hypochlorite Treatment on the Emerging Pollutant Candesartan: The Formation of Degradation Byproducts and Their Toxicological Profiles.
Autorzy :
Luongo G; Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Saviano L; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
Libralato G; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
Guida M; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
Siciliano A; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
Previtera L; Associazione Italiana per la Promozione delle Ricerche su Ambiente e Salute umana, 82030 Dugenta, Italy.
Di Fabio G; Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Zarrelli A; Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jun 05; Vol. 26 (11). Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Benzimidazoles/*analysis
Biphenyl Compounds/*analysis
Hypochlorous Acid/*chemistry
Tetrazoles/*analysis
Water Pollutants, Chemical/*analysis
Aliivibrio fischeri/drug effects ; Animals ; Benzimidazoles/toxicity ; Biphenyl Compounds/toxicity ; Chlorophyceae/drug effects ; Daphnia/drug effects ; Europe ; Lakes/chemistry ; North America ; Rivers/chemistry ; Tetrazoles/toxicity ; Waste Water/chemistry ; Water Pollutants, Chemical/toxicity ; Water Purification
Czasopismo naukowe
Tytuł :
Effect of Gonadectomy and Angiotensin II Receptor Blockade in a Mouse Model of Isoproterenol-induced Cardiac Diastolic Dysfunction.
Autorzy :
Asai K; Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital.
Murai K; Department of Cardiovascular Medicine, Nippon Medical School.
Shirakabe A; Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital.
Kamiya M; Department of Cardiovascular Medicine, Nippon Medical School.
Noma S; Department of Cardiovascular Medicine, Nippon Medical School.
Sato N; Department of Cardiovascular Medicine, Nippon Medical School.
Mizuno K; Mitsukoshi Health and Welfare Foundation.
Shimizu W; Department of Cardiovascular Medicine, Nippon Medical School.
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Źródło :
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi [J Nippon Med Sch] 2021 May 12; Vol. 88 (2), pp. 113-120. Date of Electronic Publication: 2020 May 30.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin Receptor Antagonists/*therapeutic use
Cardiomegaly/*etiology
Cardiomegaly/*prevention & control
Castration/*adverse effects
Heart Failure/*etiology
Heart Failure/*prevention & control
Imidazoles/*therapeutic use
Isoproterenol/*adverse effects
Tetrazoles/*therapeutic use
Angiotensin Receptor Antagonists/pharmacology ; Animals ; Cardiomegaly/diagnosis ; Cardiomegaly/physiopathology ; Diastole ; Disease Models, Animal ; Echocardiography ; Female ; Heart Failure/diagnosis ; Heart Failure/physiopathology ; Heart Ventricles/pathology ; Humans ; Imidazoles/pharmacology ; Male ; Mice, Inbred Strains ; Stroke Volume ; Tetrazoles/pharmacology
Czasopismo naukowe
Tytuł :
Safety and tolerability of sacubitril-valsartan: a systematic review and meta-analysis.
Autorzy :
Martins E Pereira G; Faculdade de Medicina, Universidade de Lisboa. Avenida Professor Egas Moniz, Lisboa, Portugal.
S Duarte G; Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa. Avenida Professor Egas Moniz, Lisboa, Portugal.; Faculdade de Medicina, Instituto de Medicina Molecular, Universidade de Lisboa. Avenida Professor Egas Moniz, Lisboa, Portugal.; Faculdade de Medicina, Centro de Estudos de Medicina Baseada na Evidência, Universidade de Lisboa, Lisboa, Portugal.
Katerenchuk V; Faculdade de Medicina, Universidade de Lisboa. Avenida Professor Egas Moniz, Lisboa, Portugal.
Costa J; Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa. Avenida Professor Egas Moniz, Lisboa, Portugal.; Faculdade de Medicina, Instituto de Medicina Molecular, Universidade de Lisboa. Avenida Professor Egas Moniz, Lisboa, Portugal.; Faculdade de Medicina, Centro de Estudos de Medicina Baseada na Evidência, Universidade de Lisboa, Lisboa, Portugal.
David C; Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa. Avenida Professor Egas Moniz, Lisboa, Portugal.; Faculdade de Medicina, Instituto de Medicina Molecular, Universidade de Lisboa. Avenida Professor Egas Moniz, Lisboa, Portugal.; Serviço de Cardiologia, Hospital Universitário de Santa Maria (CHULN), CAML, Centro Cardiovascular da Universidade de Lisboa - CCUL, Faculdade de Medicina, Universidade de Lisboa. Avenida Professor Egas Moniz, Lisboa, Portugal.
Ferreira JJ; Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa. Avenida Professor Egas Moniz, Lisboa, Portugal.; Faculdade de Medicina, Instituto de Medicina Molecular, Universidade de Lisboa. Avenida Professor Egas Moniz, Lisboa, Portugal.; CNS-Campus Neurológico Sénior, Torres Vedras, Portugal.
Pinto FJ; Serviço de Cardiologia, Hospital Universitário de Santa Maria (CHULN), CAML, Centro Cardiovascular da Universidade de Lisboa - CCUL, Faculdade de Medicina, Universidade de Lisboa. Avenida Professor Egas Moniz, Lisboa, Portugal.
Caldeira D; Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa. Avenida Professor Egas Moniz, Lisboa, Portugal.; Faculdade de Medicina, Instituto de Medicina Molecular, Universidade de Lisboa. Avenida Professor Egas Moniz, Lisboa, Portugal.; Serviço de Cardiologia, Hospital Universitário de Santa Maria (CHULN), CAML, Centro Cardiovascular da Universidade de Lisboa - CCUL, Faculdade de Medicina, Universidade de Lisboa. Avenida Professor Egas Moniz, Lisboa, Portugal.
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Źródło :
Expert opinion on drug safety [Expert Opin Drug Saf] 2021 May; Vol. 20 (5), pp. 577-588. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Aminobutyrates/*adverse effects
Angiotensin Receptor Antagonists/*adverse effects
Tetrazoles/*adverse effects
Aminobutyrates/administration & dosage ; Angioedema/chemically induced ; Angioedema/epidemiology ; Angiotensin Receptor Antagonists/administration & dosage ; Drug Combinations ; Humans ; Hypotension/chemically induced ; Hypotension/epidemiology ; Randomized Controlled Trials as Topic ; Risk ; Tetrazoles/administration & dosage
Czasopismo naukowe
Tytuł :
Toxicity, residue and risk assessment of tetraniliprole in soil-earthworm microcosms.
Autorzy :
Ma D; College of Plant Protection, China Agricultural University, No. 2, Yuanmingyuan West Road, Haidian District, Beijing 100193, People's Republic of China.
Yang S; Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, 61 Daizong Street, Tai'an, Shandong 271018, People's Republic of China.
Jiang J; Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, 61 Daizong Street, Tai'an, Shandong 271018, People's Republic of China.
Zhu J; Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, 61 Daizong Street, Tai'an, Shandong 271018, People's Republic of China.
Li B; Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, 61 Daizong Street, Tai'an, Shandong 271018, People's Republic of China.
Mu W; Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, 61 Daizong Street, Tai'an, Shandong 271018, People's Republic of China.
Dou D; College of Plant Protection, China Agricultural University, No. 2, Yuanmingyuan West Road, Haidian District, Beijing 100193, People's Republic of China.
Liu F; Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, 61 Daizong Street, Tai'an, Shandong 271018, People's Republic of China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Apr 15; Vol. 213, pp. 112061. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article
MeSH Terms :
Insecticides/*toxicity
Pyrazoles/*toxicity
Pyridines/*toxicity
Soil Pollutants/*toxicity
Tetrazoles/*toxicity
Animals ; Insecticides/analysis ; Moths ; Oligochaeta ; Pyrazoles/analysis ; Pyridines/analysis ; Risk Assessment ; Seeds/chemistry ; Soil/chemistry ; Soil Pollutants/analysis ; Tetrazoles/analysis ; Zea mays
Czasopismo naukowe
Tytuł :
Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum .
Autorzy :
Lawong A; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Gahalawat S; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Okombo J; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.
Striepen J; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.
Yeo T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.
Mok S; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.
Deni I; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.
Bridgford JL; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.
Niederstrasser H; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Zhou A; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Posner B; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Wittlin S; Swiss Tropical and Public Health Institute, 4002 Basel, Switzerland.; University of Basel, 4002 Basel, Switzerland.
Gamo FJ; Medicines Development Campus, GlaxoSmithKline, Tres Cantos, 28760 Madrid, Spain.
Crespo B; Medicines Development Campus, GlaxoSmithKline, Tres Cantos, 28760 Madrid, Spain.
Churchyard A; Department of Life Sciences, Imperial College London, SW7 2AZ South Kensington, U.K.
Baum J; Department of Life Sciences, Imperial College London, SW7 2AZ South Kensington, U.K.
Mittal N; Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California 92093, United States.
Winzeler E; Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California 92093, United States.
Laleu B; Medicines for Malaria Venture, 1215 Geneva, Switzerland.
Palmer MJ; Medicines for Malaria Venture, 1215 Geneva, Switzerland.
Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Fidock DA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, United States.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.
Ready JM; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Phillips MA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Mar 11; Vol. 64 (5), pp. 2739-2761. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Amides/*pharmacology
Antimalarials/*pharmacology
Hemoglobins/*metabolism
Plasmodium falciparum/*drug effects
Tetrazoles/*pharmacology
Amides/chemical synthesis ; Amides/pharmacokinetics ; Antimalarials/chemical synthesis ; Antimalarials/pharmacokinetics ; Drug Resistance, Microbial/drug effects ; Hemeproteins/antagonists & inhibitors ; Hep G2 Cells ; Humans ; Molecular Structure ; Parasitic Sensitivity Tests ; Plasmodium falciparum/metabolism ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/pharmacokinetics ; Small Molecule Libraries/pharmacology ; Structure-Activity Relationship ; Tetrazoles/chemical synthesis ; Tetrazoles/pharmacokinetics
Czasopismo naukowe
Tytuł :
Synthesis, fungicidal activity, and 3D-QSAR of tetrazole derivatives containing phenyloxadiazole moieties.
Autorzy :
Li YT; Dongguan HEC Pesticides R&D Co., Ltd, Dongguan 523871, PR China.
Yao WQ; Dongguan HEC Pesticides R&D Co., Ltd, Dongguan 523871, PR China.
Zhou S; Dongguan HEC Pesticides R&D Co., Ltd, Dongguan 523871, PR China.
Xu JX; Dongguan HEC Pesticides R&D Co., Ltd, Dongguan 523871, PR China.
Lu H; Dongguan HEC Pesticides R&D Co., Ltd, Dongguan 523871, PR China.
Lin J; Dongguan HEC Pesticides R&D Co., Ltd, Dongguan 523871, PR China; College of Chemistry Biology and Environmental Engineering, Xiangnan University, Chenzhou 423000, PR China. Electronic address: .
Hu XY; Dongguan HEC Pesticides R&D Co., Ltd, Dongguan 523871, PR China.
Zhang SK; Dongguan HEC Pesticides R&D Co., Ltd, Dongguan 523871, PR China.
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Feb 15; Vol. 34, pp. 127762. Date of Electronic Publication: 2020 Dec 24.
Typ publikacji :
Journal Article
MeSH Terms :
Quantitative Structure-Activity Relationship*
Fungicides, Industrial/*pharmacology
Oomycetes/*drug effects
Oxadiazoles/*pharmacology
Tetrazoles/*pharmacology
Cucumis sativus/drug effects ; Cucumis sativus/microbiology ; Dose-Response Relationship, Drug ; Fungicides, Industrial/chemical synthesis ; Fungicides, Industrial/chemistry ; Microbial Sensitivity Tests ; Molecular Structure ; Oxadiazoles/chemistry ; Plant Diseases/microbiology ; Tetrazoles/chemical synthesis ; Tetrazoles/chemistry
Czasopismo naukowe
Tytuł :
Simultaneous determination of sacubitrilat and fimasartan in rat plasma by a triple quad liquid chromatography-tandem mass spectrometry method utilizing electrospray ionization in positive mode.
Autorzy :
Giri P; Drug Metabolism and Pharmacokinetics Laboratory, Zydus Research Centre, Ahmedabad, Gujarat, India.
Joshi V; Drug Metabolism and Pharmacokinetics Laboratory, Zydus Research Centre, Ahmedabad, Gujarat, India.
Giri S; Drug Metabolism and Pharmacokinetics Laboratory, Zydus Research Centre, Ahmedabad, Gujarat, India.
Delvadia P; Drug Metabolism and Pharmacokinetics Laboratory, Zydus Research Centre, Ahmedabad, Gujarat, India.
Jain MR; Drug Metabolism and Pharmacokinetics Laboratory, Zydus Research Centre, Ahmedabad, Gujarat, India.
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Źródło :
Biomedical chromatography : BMC [Biomed Chromatogr] 2021 Feb; Vol. 35 (2), pp. e4981. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Journal Article
MeSH Terms :
Aminobutyrates/*blood
Biphenyl Compounds/*blood
Chromatography, Liquid/*methods
Pyrimidines/*blood
Tandem Mass Spectrometry/*methods
Tetrazoles/*blood
Aminobutyrates/chemistry ; Aminobutyrates/pharmacokinetics ; Animals ; Biphenyl Compounds/chemistry ; Biphenyl Compounds/pharmacokinetics ; Linear Models ; Male ; Prodrugs ; Pyrimidines/chemistry ; Pyrimidines/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Reproducibility of Results ; Sensitivity and Specificity ; Spectrometry, Mass, Electrospray Ionization/methods ; Tetrazoles/chemistry ; Tetrazoles/pharmacokinetics
Czasopismo naukowe
Tytuł :
Cenobamate tablets as a treatment for focal-onset seizures in adults.
Autorzy :
Steinhoff BJ; Kork Epilepsy Center, Kehl-Kork, Germany.; Department of Neurology, Albert-Ludwigs University of Freiburg, Freiburg, Germany.
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Źródło :
Expert review of clinical pharmacology [Expert Rev Clin Pharmacol] 2021 Feb; Vol. 14 (2), pp. 161-172. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anticonvulsants/*administration & dosage
Carbamates/*administration & dosage
Chlorophenols/*administration & dosage
Epilepsies, Partial/*drug therapy
Tetrazoles/*administration & dosage
Adult ; Animals ; Anticonvulsants/adverse effects ; Anticonvulsants/pharmacology ; Carbamates/adverse effects ; Carbamates/pharmacology ; Chlorophenols/adverse effects ; Chlorophenols/pharmacology ; Humans ; Randomized Controlled Trials as Topic ; Tablets ; Tetrazoles/adverse effects ; Tetrazoles/pharmacology
Czasopismo naukowe
Tytuł :
Evaluation of Drug Dissolution Rate in Co-amorphous and Co-crystal Binary Drug Delivery Systems by Thermodynamic and Kinetic Methods.
Autorzy :
Hu C; Medical College, Qinghai University, Xining, 810001, Qinghai, People's Republic of China. .; State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, 810001, Qinghai, People's Republic of China. .
Zhang F; Medical College, Qinghai University, Xining, 810001, Qinghai, People's Republic of China.
Fan H; Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, Xining, 810001, Qinghai, People's Republic of China.
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2021 Jan 03; Vol. 22 (1), pp. 21. Date of Electronic Publication: 2021 Jan 03.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Thermodynamics*
Aminobutyrates/*administration & dosage
Angiotensin Receptor Antagonists/*administration & dosage
Antihypertensive Agents/*administration & dosage
Tetrazoles/*administration & dosage
Valsartan/*administration & dosage
Aminobutyrates/chemistry ; Aminobutyrates/pharmacokinetics ; Angiotensin Receptor Antagonists/chemistry ; Angiotensin Receptor Antagonists/pharmacokinetics ; Animals ; Antihypertensive Agents/chemistry ; Antihypertensive Agents/pharmacokinetics ; Biological Availability ; Dogs ; Drug Combinations ; Drug Stability ; Kinetics ; Pharmaceutical Preparations ; Powder Diffraction ; Solubility ; Tetrazoles/chemistry ; Tetrazoles/pharmacokinetics ; Valsartan/chemistry ; Valsartan/pharmacokinetics
Czasopismo naukowe
Tytuł :
Development of autotaxin inhibitors: A series of tetrazole cinnamides.
Autorzy :
Thomson CG; Global Discovery Chemistry, Novartis Institutes For Biomedical Research, Horsham, UK. Electronic address: .
Le Grand D; Global Discovery Chemistry, Novartis Institutes For Biomedical Research, Horsham, UK.
Dowling M; Respiratory Disease Area, Novartis Institutes For Biomedical Research, Horsham, UK.
Beattie D; Global Discovery Chemistry, Novartis Institutes For Biomedical Research, Horsham, UK.
Elphick L; Respiratory Disease Area, Novartis Institutes For Biomedical Research, Horsham, UK.
Faller M; Department of Chemical Biology and Therapeutics, Novartis Institutes For Biomedical Research, Basel, Switzerland.
Freeman M; Respiratory Disease Area, Novartis Institutes For Biomedical Research, Horsham, UK.
Hardaker E; Respiratory Disease Area, Novartis Institutes For Biomedical Research, Horsham, UK.
Head V; Metabolism and Pharmacokinetics, Novartis Institutes For Biomedical Research, Horsham, UK.
Hemmig R; Department of Chemical Biology and Therapeutics, Novartis Institutes For Biomedical Research, Basel, Switzerland.
Hill J; Respiratory Disease Area, Novartis Institutes For Biomedical Research, Horsham, UK.
Lister A; Global Discovery Chemistry, Novartis Institutes For Biomedical Research, Horsham, UK.
Pascoe D; Global Discovery Chemistry, Novartis Institutes For Biomedical Research, Horsham, UK.
Rieffel S; Department of Chemical Biology and Therapeutics, Novartis Institutes For Biomedical Research, Basel, Switzerland.
Shrestha B; Department of Chemical Biology and Therapeutics, Novartis Institutes For Biomedical Research, Basel, Switzerland.
Steward O; Global Discovery Chemistry, Novartis Institutes For Biomedical Research, Horsham, UK.
Zink F; Department of Chemical Biology and Therapeutics, Novartis Institutes For Biomedical Research, Basel, Switzerland.
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Jan 01; Vol. 31, pp. 127663. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Development*
Amides/*pharmacology
Cinnamates/*pharmacology
Enzyme Inhibitors/*pharmacology
Phosphoric Diester Hydrolases/*metabolism
Tetrazoles/*pharmacology
Amides/chemical synthesis ; Amides/chemistry ; Animals ; Cinnamates/chemical synthesis ; Cinnamates/chemistry ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Mice ; Models, Molecular ; Molecular Structure ; Rats ; Structure-Activity Relationship ; Tetrazoles/chemical synthesis ; Tetrazoles/chemistry
Czasopismo naukowe

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