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Tytuł :
The use of national reimbursement reports to support formulary decisions of the hospital's Drug and Therapeutics Committee: a comparative analysis.
Autorzy :
Claus B; Pharmacy Department, Ghent University Hospital, Ghent, Belgium. .; Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium. .
Commeyne S; Pharmacy Department, Ghent University Hospital, Ghent, Belgium.
Van de Casteele M; National Institute for Health and Disability Insurance, Brussels, Belgium.
Rottey S; Drug Research Unit, Ghent University Hospital, Ghent, Belgium.; Department of Medical Oncology, Ghent University Hospital, Ghent, Belgium.
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Źródło :
International journal of clinical pharmacy [Int J Clin Pharm] 2022 Jun; Vol. 44 (3), pp. 769-774. Date of Electronic Publication: 2022 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
Pharmacy and Therapeutics Committee*
Research Design*
Belgium ; Hospitals ; Humans ; Retrospective Studies
Czasopismo naukowe
Tytuł :
[New approaches in the treatment of heart failure: A change in therapeutic strategy].
Autorzy :
Obaya Rebollar JC; Coordinador del Grupo de Trabajo de Enfermedades Cardiovasculares semFYC, España. Electronic address: .
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Transliterated Title :
Nuevos enfoques en el tratamiento de la insuficiencia cardiaca: un cambio en la estrategia terapéutica.
Źródło :
Atencion primaria [Aten Primaria] 2022 May; Vol. 54 (5), pp. 102309. Date of Electronic Publication: 2022 Feb 28.
Typ publikacji :
Editorial
MeSH Terms :
Heart Failure*/therapy
Therapeutics*/methods
Humans
Opinia redakcyjna
Tytuł :
Phase 3 trial of lumasiran for primary hyperoxaluria type 1: A new RNAi therapeutic in infants and young children.
Autorzy :
Sas DJ; Division of Pediatric Nephrology and Hypertension, Mayo Clinic, Rochester, MN. Electronic address: .
Magen D; Pediatric Nephrology Institute, Rambam Health Care Campus, Haifa, Israel.
Hayes W; Department of Paediatric Nephrology, Great Ormond Street Hospital, London, United Kingdom.
Shasha-Lavsky H; Pediatric Nephrology Unit, Galilee Medical Center, Nahariya, Israel.
Michael M; Division of Pediatric Nephrology, Department of Pediatrics, Texas Children's Hospital/Baylor College of Medicine, Houston, TX.
Schulte I; Department of Pediatric Nephrology, University of Bonn, Bonn, Germany.
Sellier-Leclerc AL; Hôpital Femme Mère Enfant and Centre d'Investigation Clinique Inserm, Hospices Civils de Lyon, ERKnet, Bron, France.
Lu J; Alnylam Pharmaceuticals, Cambridge, MA.
Seddighzadeh A; Alnylam Pharmaceuticals, Cambridge, MA.
Habtemariam B; Alnylam Pharmaceuticals, Cambridge, MA.
McGregor TL; Alnylam Pharmaceuticals, Cambridge, MA.
Fujita KP; Alnylam Pharmaceuticals, Cambridge, MA.
Frishberg Y; Division of Pediatric Nephrology, Shaare Zedek Medical Center, Jerusalem, Israel; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address: .
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Corporate Authors :
ILLUMINATE-B Workgroup
Źródło :
Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2022 Mar; Vol. 24 (3), pp. 654-662. Date of Electronic Publication: 2021 Dec 08.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hyperoxaluria, Primary*/complications
Hyperoxaluria, Primary*/genetics
Hyperoxaluria, Primary*/therapy
RNAi Therapeutics*
Child, Preschool ; Humans ; Infant ; RNA Interference ; RNA, Small Interfering
SCR Disease Name :
Primary hyperoxaluria type 1
Czasopismo naukowe
Tytuł :
Combination Cancer Immunotherapy with Dendritic Cell Vaccine and Nanoparticles Loaded with Interleukin-15 and Anti-beta-catenin siRNA Significantly Inhibits Cancer Growth and Induces Anti-Tumor Immune Response.
Autorzy :
Kheshti AMS; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Hajizadeh F; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Barshidi A; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Rashidi B; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Ebrahimi F; Nanoparticle Process Technology, Faculty of Engineering, University of Duisburg-Essen, Duisburg, Germany.
Bahmanpour S; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Karpisheh V; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Noukabadi FK; Department of Biotechnology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
Kiani FK; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Hassannia H; Immunogenetic Research Center, Faculty of Medicine and Amol Faculty of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran.
Atyabi F; Nanotechnology Research Centre, Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Kiaie SH; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah, 6715847141, Iran.
Kashanchi F; Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, Virginia, USA.
Navashenaq JG; Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran.
Mohammadi H; Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Bagherifar R; Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah, 6715847141, Iran.
Jafari R; Nephrology and Kidney Transplant Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.; Hematology, Immune Cell Therapy, and Stem Cell Transplantation Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Zolbanin NM; Hematology, Immune Cell Therapy, and Stem Cell Transplantation Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran. .; Experimental and Applied Pharmaceutical Research Center, Urmia University of Medical Sciences, Urmia, Iran. .; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran. .
Jadidi-Niaragh F; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. .; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. .; Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran. .
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Źródło :
Pharmaceutical research [Pharm Res] 2022 Feb; Vol. 39 (2), pp. 353-367. Date of Electronic Publication: 2022 Feb 15.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Carriers*
Magnetic Iron Oxide Nanoparticles*
RNAi Therapeutics*
Antineoplastic Agents/*administration & dosage
Cancer Vaccines/*administration & dosage
Dendritic Cells/*transplantation
Interleukin-15/*administration & dosage
Melanoma, Experimental/*therapy
RNA, Small Interfering/*administration & dosage
Skin Neoplasms/*therapy
beta Catenin/*genetics
Animals ; Antineoplastic Agents/chemistry ; Cancer Vaccines/immunology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dendritic Cells/immunology ; Drug Compounding ; Female ; Gene Expression Regulation, Neoplastic ; Interleukin-15/chemistry ; Lymphocytes, Tumor-Infiltrating/immunology ; Melanoma, Experimental/genetics ; Melanoma, Experimental/immunology ; Melanoma, Experimental/pathology ; Mice, Inbred BALB C ; RNA, Small Interfering/genetics ; Skin Neoplasms/genetics ; Skin Neoplasms/immunology ; Skin Neoplasms/pathology ; Tumor Burden/drug effects ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Questioning Established Theories and Treatment Methods Related to Iron and Other Metal Metabolic Changes, Affecting All Major Diseases and Billions of Patients.
Autorzy :
Kontoghiorghes GJ; Postgraduate Research Institute of Science, Technology, Environment and Medicine, 3 Ammochostou Street, Limassol 3021, Cyprus.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 25; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 25.
Typ publikacji :
Editorial
MeSH Terms :
Iron/*metabolism
Metals/*metabolism
Therapeutics/*trends
Chelation Therapy ; Disease/classification ; Disease/etiology ; Drug Therapy/trends ; Humans ; Iron Chelating Agents/therapeutic use ; Iron Deficiencies/drug therapy ; Iron Overload/drug therapy ; Therapeutics/methods
Opinia redakcyjna
Tytuł :
siRNA-Based Carrier-Free System for Synergistic Chemo/Chemodynamic/RNAi Therapy of Drug-Resistant Tumors.
Autorzy :
Jiang Y; MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China.
Liu Y; National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, College of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China.
Wang M; MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China.
Li Z; MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China.
Su L; MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China.
Xu X; MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China.
Xing C; Fujian Key Laboratory of Functional Marine Sensing Materials, Center for Advanced Marine Materials and Smart Sensors, Minjiang University, Fuzhou 350108, People's Republic of China.
Li J; National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, College of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China.
Lin L; MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China.
Lu C; MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China.
Yang H; MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2022 Jan 12; Vol. 14 (1), pp. 361-372. Date of Electronic Publication: 2021 Dec 21.
Typ publikacji :
Journal Article
MeSH Terms :
RNAi Therapeutics*
Antineoplastic Agents/*pharmacology
Biocompatible Materials/*pharmacology
Cisplatin/*pharmacology
Drug Resistance, Multiple/*drug effects
Drug Resistance, Neoplasm/*drug effects
RNA, Small Interfering/*pharmacology
Animals ; Antineoplastic Agents/chemistry ; Biocompatible Materials/chemistry ; Cell Survival/drug effects ; Cisplatin/chemistry ; Copper/chemistry ; Copper/pharmacology ; Drug Screening Assays, Antitumor ; Humans ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Materials Testing ; Mice ; Optical Imaging ; Particle Size ; RNA, Small Interfering/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Advances in siRNA therapeutics and synergistic effect on siRNA activity using emerging dual ribose modifications.
Autorzy :
Gangopadhyay S; Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, India.
Gore KR; Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, India.
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Źródło :
RNA biology [RNA Biol] 2022 Jan; Vol. 19 (1), pp. 452-467.
Typ publikacji :
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms :
RNAi Therapeutics*
Ribose*
RNA Interference ; RNA, Small Interfering/genetics
Czasopismo naukowe
Tytuł :
Preclinical Research Strategy Development for RNAi-Based Therapies in Oncology Using Patient-Centered Information from Public Databases of Human Protein Atlas and R2Genomics Platform.
Autorzy :
Dey A; MicroCures Inc, Bronx, NY, USA. .
Balachandran I; New Rochelle High School, New Rochelle, NY, USA.
Solis A; Dobbs Ferry High School, Dobbs Ferry, NY, USA.
Sharp DJ; MicroCures Inc, Bronx, NY, USA. .; Albert Einstein College of Medicine, Bronx, NY, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2423, pp. 181-185.
Typ publikacji :
Journal Article
MeSH Terms :
RNAi Therapeutics*
Research Design*
Humans ; Medical Oncology ; Patient-Centered Care ; RNA, Small Interfering/genetics ; RNA, Small Interfering/therapeutic use
Czasopismo naukowe
Tytuł :
The potential role of mesenchymal stem cells in modulating antiageing process.
Autorzy :
Govindasamy V; Research and Development Department, CryoCord Sdn Bhd, Bio-X Centre, Cyberjaya, Selangor, Malaysia.
Rajendran A; Research and Development Department, CryoCord Sdn Bhd, Bio-X Centre, Cyberjaya, Selangor, Malaysia.
Lee ZX; Research and Development Department, CryoCord Sdn Bhd, Bio-X Centre, Cyberjaya, Selangor, Malaysia.
Ooi GC; Research and Development Department, CryoCord Sdn Bhd, Bio-X Centre, Cyberjaya, Selangor, Malaysia.
Then KY; Research and Development Department, CryoCord Sdn Bhd, Bio-X Centre, Cyberjaya, Selangor, Malaysia.; Brighton Healthcare (Bio-X Healthcare Sdn Bhd), Bio-X Centre, Cyberjaya, Selangor, Malaysia.
Then KL; Research and Development Department, CryoCord Sdn Bhd, Bio-X Centre, Cyberjaya, Selangor, Malaysia.
Gayathri M; Brighton Healthcare (Bio-X Healthcare Sdn Bhd), Bio-X Centre, Cyberjaya, Selangor, Malaysia.
Kumar Das A; Deparment of Surgery, IQ City Medical College, Durgapur, West Bengal, India.
Cheong SK; Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman (UTAR), Kajang, Selangor, Malaysia.
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Źródło :
Cell biology international [Cell Biol Int] 2021 Oct; Vol. 45 (10), pp. 1999-2016. Date of Electronic Publication: 2021 Jul 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Aging*
Immunomodulation*
Paracrine Communication*
Therapeutics*
Hematopoietic Stem Cells/*cytology
Mesenchymal Stem Cell Transplantation/*methods
Animals ; Humans
Czasopismo naukowe
Tytuł :
Development of Lipidoid Nanoparticles for siRNA Delivery to Neural Cells.
Autorzy :
Khare P; Graduate School of Pharmaceutical Sciences, Duquesne University, 453 Mellon Hall, 600 Forbes Avenue, Pittsburgh, Pennsylvania, 15282, USA.
Dave KM; Graduate School of Pharmaceutical Sciences, Duquesne University, 453 Mellon Hall, 600 Forbes Avenue, Pittsburgh, Pennsylvania, 15282, USA.
Kamte YS; Graduate School of Pharmaceutical Sciences, Duquesne University, 453 Mellon Hall, 600 Forbes Avenue, Pittsburgh, Pennsylvania, 15282, USA.
Manoharan MA; Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA.
O'Donnell LA; Graduate School of Pharmaceutical Sciences, Duquesne University, 453 Mellon Hall, 600 Forbes Avenue, Pittsburgh, Pennsylvania, 15282, USA.
Manickam DS; Graduate School of Pharmaceutical Sciences, Duquesne University, 453 Mellon Hall, 600 Forbes Avenue, Pittsburgh, Pennsylvania, 15282, USA. .
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Źródło :
The AAPS journal [AAPS J] 2021 Dec 06; Vol. 24 (1), pp. 8. Date of Electronic Publication: 2021 Dec 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nanoparticles*
RNAi Therapeutics*
Transfection*
Ganglia, Spinal/*metabolism
Lipids/*chemistry
Neurons/*metabolism
RNA, Small Interfering/*administration & dosage
Animals ; Carbocyanines/metabolism ; Fluorescent Dyes/metabolism ; Ganglia, Spinal/cytology ; Humans ; MCF-7 Cells ; Microscopy, Fluorescence ; Nanotechnology ; Primary Cell Culture ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Rats ; Time Factors
Czasopismo naukowe
Tytuł :
The price of certainty: when is a new therapy good enough?
Autorzy :
Fiehler J; Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany .
Zeleňák K; Department of Radiology, Comenius University in Bratislava Jessenius Faculty of Medicine in Martin Clinic of Radiology, Martin, Slovakia.
Zapf A; Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
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Źródło :
Journal of neurointerventional surgery [J Neurointerv Surg] 2021 Dec; Vol. 13 (12), pp. 1065-1066.
Typ publikacji :
Editorial
MeSH Terms :
Therapeutics*
Uncertainty
Opinia redakcyjna
Tytuł :
Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1. Reply.
Autorzy :
Garrelfs SF; Emma Children's Hospital, Amsterdam, the Netherlands .
Gansner JM; Alnylam Pharmaceuticals, Cambridge, MA.
Lieske JC; Mayo Clinic, Rochester, MN.
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Źródło :
The New England journal of medicine [N Engl J Med] 2021 Nov 11; Vol. 385 (20), pp. e69.
Typ publikacji :
Letter; Comment
MeSH Terms :
Hyperoxaluria, Primary*/genetics
Hyperoxaluria, Primary*/therapy
RNAi Therapeutics*
Humans ; RNA Interference
SCR Disease Name :
Primary hyperoxaluria type 1
Opinia redakcyjna
Tytuł :
Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1.
Autorzy :
Shah VN; Barbara Davis Center for Diabetes, Aurora, CO .
Pyle L; Barbara Davis Center for Diabetes, Aurora, CO .
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Źródło :
The New England journal of medicine [N Engl J Med] 2021 Nov 11; Vol. 385 (20), pp. e69.
Typ publikacji :
Letter; Comment
MeSH Terms :
Hyperoxaluria, Primary*/genetics
Hyperoxaluria, Primary*/therapy
RNAi Therapeutics*
Humans ; RNA Interference
SCR Disease Name :
Primary hyperoxaluria type 1
Opinia redakcyjna
Tytuł :
Inclisiran in lipid management: A Literature overview and future perspectives.
Autorzy :
Scicchitano P; Cardiology Department, Hospital 'F. Perinei' Altamura (BA), Italy. Electronic address: .
Milo M; Cardiology Section, Department of Emergency and Organ Transplantation, University of Bari 'A. Moro', Bari, Italy.
Mallamaci R; Department of Bioscience, Biotechnology and Biopharmaceutics, University Aldo Moro Bari, Bari, Italy.
De Palo M; Cardiac Surgery Section, Department of Emergency and Organ Transplantation, University of Bari 'A. Moro', Bari, Italy.
Caldarola P; Cardiology Department, Hospital 'San Paolo' Bari, Italy.
Massari F; Cardiology Department, Hospital 'F. Perinei' Altamura (BA), Italy.
Gabrielli D; Cardiology Unit, Cardiotoracovascular Department, Azienda Ospedaliera San Camillo Forlanini, Roma, Italy.
Colivicchi F; Division of Cardiology, Hospital 'S. Filippo Neri', Rome, Italy.
Ciccone MM; Cardiology Section, Department of Emergency and Organ Transplantation, University of Bari 'A. Moro', Bari, Italy.
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Nov; Vol. 143, pp. 112227. Date of Electronic Publication: 2021 Sep 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
RNAi Therapeutics*
Cardiovascular Diseases/*prevention & control
Cholesterol, LDL/*blood
Dyslipidemias/*therapy
Proprotein Convertase 9/*metabolism
RNA, Small Interfering/*therapeutic use
Animals ; Biomarkers/blood ; Cardiovascular Diseases/epidemiology ; Down-Regulation ; Dyslipidemias/enzymology ; Dyslipidemias/epidemiology ; Dyslipidemias/genetics ; Heart Disease Risk Factors ; Humans ; Primary Prevention ; Proprotein Convertase 9/genetics ; RNA, Small Interfering/adverse effects ; RNA, Small Interfering/pharmacokinetics ; Risk Assessment ; Secondary Prevention ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Protecting the public from the adverse effects of confused research ethics.
Autorzy :
Chalmers I; Centre for Evidence-Based Medicine, Department of Primary Care, University of Oxford, Oxford OX2 6GG, UK.
Glasziou P; Institute for Evidence-Based Healthcare, Faculty of Health Sciences and Medicine, Bond University, Gold Coast QLD 4229, Australia.
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Źródło :
Journal of the Royal Society of Medicine [J R Soc Med] 2021 Nov; Vol. 114 (11), pp. 507-512. Date of Electronic Publication: 2021 Oct 26.
Typ publikacji :
Journal Article
MeSH Terms :
Ethics Committees, Research*
Therapeutics*/adverse effects
Uncertainty*
Therapeutic Human Experimentation/*ethics
Clinical Trials as Topic/ethics ; Ethics, Professional ; Humans ; Therapeutic Human Experimentation/legislation & jurisprudence
Czasopismo naukowe
Tytuł :
Kidney Allograft Fibrosis: Diagnostic and Therapeutic Strategies.
Autorzy :
Saritas T; Department of Internal Medicine, Division of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany.; Institute of Experimental Medicine and Systems Biology, University Hospital RWTH Aachen, Aachen, Germany.
Kramann R; Department of Internal Medicine, Division of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany.; Institute of Experimental Medicine and Systems Biology, University Hospital RWTH Aachen, Aachen, Germany.; Department of Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands.
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Źródło :
Transplantation [Transplantation] 2021 Oct 01; Vol. 105 (10), pp. e114-e130.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Diet, Healthy*
RNAi Therapeutics*/adverse effects
Graft Survival/*drug effects
Kidney Diseases/*diagnosis
Kidney Diseases/*therapy
Kidney Transplantation/*adverse effects
Kidney Tubules/*drug effects
Renal Agents/*therapeutic use
Animals ; Atrophy ; Biomarkers/metabolism ; Biopsy ; Fibrosis ; Humans ; Immunosuppressive Agents/adverse effects ; Kidney Diseases/etiology ; Kidney Diseases/metabolism ; Kidney Tubules/diagnostic imaging ; Kidney Tubules/metabolism ; Kidney Tubules/pathology ; Predictive Value of Tests ; Renal Agents/adverse effects ; Risk Factors ; Signal Transduction ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Modulating host gene expression via gut microbiome-microRNA interplay to treat human diseases.
Autorzy :
Mody D; Transcriptome Laboratory, Centre for Emerging Diseases, Department of Biotechnology, Jaypee Institute of Information Technology, Noida, UP, India.
Verma V; Transcriptome Laboratory, Centre for Emerging Diseases, Department of Biotechnology, Jaypee Institute of Information Technology, Noida, UP, India.
Rani V; Transcriptome Laboratory, Centre for Emerging Diseases, Department of Biotechnology, Jaypee Institute of Information Technology, Noida, UP, India.
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Źródło :
Critical reviews in microbiology [Crit Rev Microbiol] 2021 Sep; Vol. 47 (5), pp. 596-611. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Gastrointestinal Microbiome*
Gene Expression Regulation*
Therapeutics*
MicroRNAs/*genetics
Animals ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/microbiology ; Cardiovascular Diseases/therapy ; Digestive System Diseases/genetics ; Digestive System Diseases/microbiology ; Digestive System Diseases/therapy ; Gastrointestinal Tract/immunology ; Gastrointestinal Tract/microbiology ; Health ; Humans ; MicroRNAs/metabolism ; Neoplasms/genetics ; Neoplasms/microbiology ; Neoplasms/therapy ; Nervous System Diseases/genetics ; Nervous System Diseases/microbiology ; Nervous System Diseases/therapy
Czasopismo naukowe
Tytuł :
Incorporation of a mock pharmacy and therapeutics committee as an entrustable professional activity supporting task.
Autorzy :
Borja-Hart NL; University of Tennessee Health Science Center College of Pharmacy, Department of Clinical Pharmacy and Translational Science, 301 S. Perimeter Park Dr., Suite 220, Nashville, TN 37211, United States. Electronic address: .
Rowe AS; University of Tennessee Health Science Center College of Pharmacy, Department of Clinical Pharmacy and Translational Science, 1924 Alcoa Highway, Box 117, Knoxville, TN 37920, United States. Electronic address: .
Gatwood J; University of Tennessee Health Science Center College of Pharmacy, Department of Clinical Pharmacy and Translational Science, 301 S. Perimeter Park Dr., Suite 220, Nashville, TN 37211, United States. Electronic address: .
Wheeler J; University of Tennessee Health Science Center College of Pharmacy, Department of Clinical Pharmacy and Translational Science, 1924 Alcoa Highway, Box 117, Knoxville, TN 37920, United States. Electronic address: .
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Źródło :
Currents in pharmacy teaching & learning [Curr Pharm Teach Learn] 2021 Jul; Vol. 13 (7), pp. 784-788. Date of Electronic Publication: 2021 Apr 02.
Typ publikacji :
Journal Article
MeSH Terms :
Pharmacy and Therapeutics Committee*
Students, Pharmacy*
Clinical Competence ; Communication ; Humans ; Surveys and Questionnaires
Czasopismo naukowe
Tytuł :
Physiologically based pharmacokinetic (PBPK) modeling of RNAi therapeutics: Opportunities and challenges.
Autorzy :
Fairman K; Division of Biochemical Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA.
Li M; Division of Biochemical Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA.
Ning B; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA.
Lumen A; Division of Biochemical Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Jul; Vol. 189, pp. 114468. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Models, Biological*
Drug Development/*methods
RNA Interference/*drug effects
RNAi Therapeutics/*methods
Animals ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/metabolism ; Drug Development/trends ; Humans ; Oligonucleotides/antagonists & inhibitors ; Oligonucleotides/genetics ; Oligonucleotides/metabolism ; RNA Interference/physiology ; RNAi Therapeutics/trends
Czasopismo naukowe

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