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Wyszukujesz frazę ""THROMBOPOIETIN"" wg kryterium: Temat


Tytuł :
[Research Status of TPO/c-MPL Signaling Pathway in Acute Myeloid Leukemia--Review].
Autorzy :
Wang N; Department of Hematology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Zhu HY; Department of Hematology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China,E-mail: .
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Źródło :
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2021 Aug; Vol. 29 (4), pp. 1351-1354.
Typ publikacji :
Journal Article
MeSH Terms :
Leukemia, Myeloid, Acute*
Receptors, Thrombopoietin*
Humans ; Neoplasm Proteins ; Proto-Oncogene Proteins/metabolism ; Receptors, Cytokine ; Signal Transduction ; Thrombopoietin
Czasopismo naukowe
Tytuł :
UK second-line paediatric primary ITP therapy analysis.
Autorzy :
Chaudhury B; Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK .; University of Manchester Medical School, Manchester, UK.
Grainger J; Department of Haematology and Oncology, Royal Manchester Children's Hospital, Manchester, UK.
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Źródło :
Archives of disease in childhood [Arch Dis Child] 2021 Sep; Vol. 106 (9), pp. 929-931. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Platelet Count/*statistics & numerical data
Purpura, Thrombocytopenic, Idiopathic/*drug therapy
Receptors, Thrombopoietin/*agonists
Case-Control Studies ; Child ; Clinical Trials as Topic ; Female ; Follow-Up Studies ; Humans ; Immunoglobulins, Intravenous/administration & dosage ; Immunoglobulins, Intravenous/therapeutic use ; Male ; Platelet Count/methods ; Receptors, Fc/administration & dosage ; Receptors, Fc/therapeutic use ; Recombinant Fusion Proteins/administration & dosage ; Recombinant Fusion Proteins/therapeutic use ; Registries ; Severity of Illness Index ; Thrombopoietin/administration & dosage ; Thrombopoietin/therapeutic use ; Treatment Outcome ; United Kingdom/epidemiology ; Watchful Waiting/methods
Raport
Tytuł :
[Thrombopoietin regulates mitochondria homeostasis for hematopoietic stem cell maintenance].
Autorzy :
Nakamura-Ishizu A; Microanatomy and Developmental Biology, Tokyo Women's Medical University.
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Źródło :
[Rinsho ketsueki] The Japanese journal of clinical hematology [Rinsho Ketsueki] 2021; Vol. 62 (5), pp. 521-527.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Hematopoietic Stem Cells*/metabolism
Thrombopoietin*
Cell Cycle ; Homeostasis ; Mitochondria ; Receptors, Thrombopoietin
Czasopismo naukowe
Tytuł :
Effectiveness and safety of romiplostim among patients with newly diagnosed, persistent and chronic ITP in routine clinical practice in central and Eastern Europe: an analysis of the PLATON study.
Autorzy :
Skopec B; Department of Hematology, University Medical Center Ljubljana, Ljubljana, Slovenia.; Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Sninska Z; Department of Hematology and Blood Transfusion, University Hospital St. Cyril and Metod, Bratislava, Slovakia.
Tzvetkov N; Clinic of Hematology, University Multiprofile Hospital for Active Treatment 'Dr. Georgi Stranski' EAD, Pleven, Bulgaria.
Ivanushkin V; Department of Biostatistics, Quartesian, Kharkov, Ukraine.
Björklöf K; Medical Affairs, Amgen (Europe North East), Rotkreuz, Switzerland.
Hippenmeyer J; Medical Affairs, Amgen (Europe) GmbH, Rotkreuz, Switzerland.
Mihaylov G; Clinic of Hematology, Specialized Hospital for Active Treatment of Hematology Diseases AD, Sofia, Bulgaria.
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Źródło :
Hematology (Amsterdam, Netherlands) [Hematology] 2021 Dec; Vol. 26 (1), pp. 497-502.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Purpura, Thrombocytopenic, Idiopathic/*drug therapy
Receptors, Fc/*therapeutic use
Recombinant Fusion Proteins/*therapeutic use
Thrombopoietin/*therapeutic use
Blood Platelets/drug effects ; Europe/epidemiology ; Europe, Eastern/epidemiology ; Humans ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Purpura, Thrombocytopenic, Idiopathic/epidemiology ; Receptors, Thrombopoietin/agonists ; Recombinant Fusion Proteins/adverse effects ; Thrombopoietin/adverse effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Use of thrombopoietin receptor agonists for immune thrombocytopenia in pregnancy: results from a multicenter study.
Autorzy :
Michel M; Department of Internal Medicine, National Reference Center for Immune Cytopenias, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris-Est Creteil, Créteil, France.
Ruggeri M; Department of Haematology, S. Bortolo Hospital, Vicenza, Italy.
Gonzalez-Lopez TJ; Department of Hematology, Hospital Universitario de Burgos, Burgos, Spain.
Alkindi S; Department of Haematology, Sultan Qaboos University, Muscat, Oman.
Cheze S; Institut d'Hématologie de Basse-Normandie, Centre Hospitalier Universitaire de Caen Normandie, Caen, France.
Ghanima W; Department of Research, Østfold Hospital Trust, Sarpsborg, Norway.; Department of Hematology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Tvedt THA; Section for Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Ebbo M; Department of Internal Medicine, La Timone University Hospital, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France.
Terriou L; Immuno-Hematology, Hôpital Claude Huriez, Lille, France; and.
Bussel JB; Weill Cornell Medicine, New York, NY.
Godeau B; Department of Internal Medicine, National Reference Center for Immune Cytopenias, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris-Est Creteil, Créteil, France.
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Źródło :
Blood [Blood] 2020 Dec 24; Vol. 136 (26), pp. 3056-3061.
Typ publikacji :
Clinical Trial; Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Thrombopoietin*
Benzoates/*administration & dosage
Hydrazines/*administration & dosage
Pregnancy Complications, Hematologic/*drug therapy
Purpura, Thrombocytopenic, Idiopathic/*drug therapy
Pyrazoles/*administration & dosage
Receptors, Fc/*administration & dosage
Recombinant Fusion Proteins/*administration & dosage
Thrombopoietin/*administration & dosage
Adult ; Benzoates/adverse effects ; Female ; Follow-Up Studies ; Humans ; Hydrazines/adverse effects ; Pregnancy ; Pyrazoles/adverse effects ; Recombinant Fusion Proteins/adverse effects ; Retrospective Studies ; Thrombopoietin/adverse effects
Czasopismo naukowe
Tytuł :
Tapering and Discontinuation of Thrombopoietin Receptor Agonist Therapy in Patients with Immune Thrombocytopenia: Results from a Modified Delphi Panel.
Autorzy :
Cooper N; Department of Haematology, Hammersmith Hospital, London, United Kingdom.
Hill QA; Department of Haematology, The Leeds Teaching Hospital, Leeds, United Kingdom.
Grainger J; Department of Pediatric Haematology, Royal Manchester Children's Hospital, Manchester, United Kingdom.
Westwood JP; Department of Haematology, University College London Hospital, London, United Kingdom.
Bradbury C; Bristol Haematology and Oncology Centre, University of Bristol, Bristol, United Kingdom.
Provan D; Department of Haematology, Barts and the London School of Medicine, London, United Kingdom.
Thachil J; Department of Haematology, Central Manchester University Hospital, Manchester, United Kingdom.
Ramscar N; Novartis UK, London, United Kingdom.
Roy A; Novartis Pharmaceuticals, East Hanover, New Jersey, USA.
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Źródło :
Acta haematologica [Acta Haematol] 2021; Vol. 144 (4), pp. 418-426. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Purpura, Thrombocytopenic, Idiopathic/*drug therapy
Receptors, Thrombopoietin/*agonists
Benzoates/therapeutic use ; Humans ; Hydrazines/therapeutic use ; Medication Adherence ; Physicians/psychology ; Platelet Count ; Pyrazoles/therapeutic use ; Receptors, Fc/therapeutic use ; Recombinant Fusion Proteins/therapeutic use ; Recurrence ; Remission Induction ; Retreatment ; Self Report ; Surveys and Questionnaires ; Thrombopoietin/therapeutic use
Czasopismo naukowe
Tytuł :
Thrombopoietin receptor agonists as an emergency treatment for severe newly diagnosed immune thrombocytopenia in children.
Autorzy :
Nolla M; Pediatric Oncology Hematology Unit, University Hospital, Toulouse, France.
Aladjidi N; Pediatric Oncology Hematology Unit, CIC 1401, INSERM CICP, and.; Centre de référence national des cytopénies autoimmunes de l'enfant, University Hospital, Bordeaux, France.
Leblanc T; Pediatric Hematology and Immunology Unit, Assistance Publique des Hôpitaux de Paris, Hôpital Robert-Debré, Paris, France.
Fernandes H; Pediatric Oncology Hematology Unit, CIC 1401, INSERM CICP, and.; Centre de référence national des cytopénies autoimmunes de l'enfant, University Hospital, Bordeaux, France.
Ducassou S; Pediatric Oncology Hematology Unit, CIC 1401, INSERM CICP, and.; Centre de référence national des cytopénies autoimmunes de l'enfant, University Hospital, Bordeaux, France.
Fahd M; Pediatric Hematology and Immunology Unit, Assistance Publique des Hôpitaux de Paris, Hôpital Robert-Debré, Paris, France.
Barlogis V; Pediatric Oncology Hematology Unit, University Hospital de la Timone, Marseille, France.
Michel M; Department of Internal Medicine, Henri Mondor University Hospital, Assistance Publique des Hôpitaux de Paris, Université Paris-Est Crétéil, Créteil, France.
Blouin P; Pediatric Oncology Hematology Unit, University Hospital, Nantes, France.
Jeziorski E; Pediatric Immunology and Infectious Disease Unit, Montpellier, France.
Benadiba J; Pediatric Oncology and Hematology, Nice, France.
Pondarre C; Pediatric Hematology, CHIC, Creteil, France.
Leverger G; Pediatric Oncology Hematology Unit, Assistance Publique des Hôpitaux de Paris-Hôpital Trousseau, Unité INSERM UMRS_938, Paris, France; and.
Pasquet M; Pediatric Oncology Hematology Unit, University Hospital, Toulouse, France.; CRCT, Team 16, IUCT-Oncopole, Toulouse, France.
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Źródło :
Blood [Blood] 2021 Jan 07; Vol. 137 (1), pp. 138-141.
Typ publikacji :
Letter; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzoates/*therapeutic use
Hemorrhage/*drug therapy
Hemorrhage/*etiology
Hydrazines/*therapeutic use
Purpura, Thrombocytopenic, Idiopathic/*drug therapy
Pyrazoles/*therapeutic use
Receptors, Fc/*therapeutic use
Recombinant Fusion Proteins/*therapeutic use
Thrombopoietin/*therapeutic use
Adolescent ; Child ; Child, Preschool ; Emergency Treatment/methods ; Female ; Humans ; Infant ; Male ; Purpura, Thrombocytopenic, Idiopathic/complications ; Receptors, Thrombopoietin/agonists
Raport
Tytuł :
Romiplostim is effective for eltrombopag-refractory aplastic anemia: results of a retrospective study.
Autorzy :
Ise M; Department of Hematology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, Shinagawa-ku, Tokyo, 141-8625, Japan.
Iizuka H; Department of Hematology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, Shinagawa-ku, Tokyo, 141-8625, Japan.
Kamoda Y; Department of Hematology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, Shinagawa-ku, Tokyo, 141-8625, Japan.
Hirao M; Department of Hematology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, Shinagawa-ku, Tokyo, 141-8625, Japan.
Kida M; Department of Hematology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, Shinagawa-ku, Tokyo, 141-8625, Japan.
Usuki K; Department of Hematology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, Shinagawa-ku, Tokyo, 141-8625, Japan. .
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Źródło :
International journal of hematology [Int J Hematol] 2020 Dec; Vol. 112 (6), pp. 787-794. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article
MeSH Terms :
Benzoates*
Drug Tolerance*
Hydrazines*
Pyrazoles*
Anemia, Aplastic/*drug therapy
Anemia, Refractory/*drug therapy
Receptors, Fc/*administration & dosage
Recombinant Fusion Proteins/*administration & dosage
Thrombopoietin/*administration & dosage
Adult ; Aged ; Aged, 80 and over ; Anemia, Aplastic/blood ; Drug Substitution ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Platelet Count ; Prospective Studies ; Receptors, Thrombopoietin/agonists ; Recombinant Fusion Proteins/pharmacology ; Retrospective Studies ; Thrombopoietin/pharmacology
Czasopismo naukowe
Tytuł :
Thrombopoietin maintains cell numbers of hematopoietic stem and progenitor cells with megakaryopoietic potential.
Autorzy :
O'Neill A; Cancer Science Institute, National University of Singapore, Singapore.
Chin D; Cancer Science Institute, National University of Singapore, Singapore.
Tan D; Cancer Science Institute, National University of Singapore, Singapore.
Abdul Majeed ABB; Cancer Science Institute, National University of Singapore, Singapore.
Nakamura-Ishizu A; Cancer Science Institute, National University of Singapore and Kumamoto University, Japan.
Suda T; Cancer Science Institute, National University of Singapore and Kumamoto University, Japan.
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Źródło :
Haematologica [Haematologica] 2021 Jul 01; Vol. 106 (7), pp. 1883-1891. Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article
MeSH Terms :
Hematopoietic Stem Cell Transplantation*
Thrombopoietin*/pharmacology
Animals ; Cell Count ; Hematopoiesis ; Hematopoietic Stem Cells ; Megakaryocytes ; Mice
Czasopismo naukowe
Tytuł :
Romiplostim in adults with newly diagnosed or persistent immune thrombocytopenia.
Autorzy :
Lozano ML; Hospital JM Morales Meseguer, Universidad de Murcia, IMIB-Arrixaca , Murcia, Spain.; Grupo de investigación CB15/00055 del Centro de Investigación Biomedica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII) , Madrid, Spain.
Godeau B; Centre de Référence des Cytopénies Auto-Immunes de l'Adulte, Service de Médecine Interne, CHU Henri Mondor, AP-HP, Université Paris-Est Créteil , Créteil, France.
Grainger J; Department of Haematology, Royal Manchester Children's Hospital , Manchester, UK.
Matzdorff A; Department of Internal Medicine II, Asklepios Clinic Uckermark , Schwedt, Germany.
Rodeghiero F; Hematology Project Foundation and Department of Hematology, S. Bortolo Hospital , Vicenza, Italy.
Hippenmeyer J; AMGEN Europe GmbH , Rotkreuz, Switzerland.
Kuter DJ; Division of Hematology, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA.
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Źródło :
Expert review of hematology [Expert Rev Hematol] 2020 Dec; Vol. 13 (12), pp. 1319-1332. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Purpura, Thrombocytopenic, Idiopathic/*drug therapy
Receptors, Fc/*therapeutic use
Recombinant Fusion Proteins/*therapeutic use
Thrombopoietin/*therapeutic use
Adrenal Cortex Hormones/therapeutic use ; Adult ; Antibodies, Neutralizing/blood ; Clinical Trials as Topic ; Combined Modality Therapy ; Drug Resistance ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Multicenter Studies as Topic ; Observational Studies as Topic ; Practice Guidelines as Topic ; Purpura, Thrombocytopenic, Idiopathic/immunology ; Purpura, Thrombocytopenic, Idiopathic/surgery ; Receptors, Fc/immunology ; Receptors, Thrombopoietin/agonists ; Recombinant Fusion Proteins/adverse effects ; Recombinant Fusion Proteins/immunology ; Rho(D) Immune Globulin/therapeutic use ; Rituximab/therapeutic use ; Splenectomy ; Thrombopoietin/adverse effects ; Thrombopoietin/immunology ; Treatment Outcome ; Watchful Waiting
Czasopismo naukowe
Tytuł :
Clinical applications of thrombopoietin silencing: A possible therapeutic role in COVID-19?
Autorzy :
Alentado VJ; Department of Neurological Surgery, Indiana University School of Medicine, IN, USA.
Moliterno AR; Department of Hematology, Johns Hopkins University School of Medicine, MD, USA.
Srour EF; Department of Medicine, Indiana University School of Medicine, IN, USA.
Kacena MA; Department of Orthopaedic Surgery, Indiana University School of Medicine, IN, USA. Electronic address: .
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Źródło :
Cytokine [Cytokine] 2021 Oct; Vol. 146, pp. 155634. Date of Electronic Publication: 2021 Jul 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Gene Silencing*
COVID-19/*therapy
Inflammation/*genetics
Thrombocytosis/*genetics
Thrombopoietin/*genetics
Thrombosis/*genetics
COVID-19/complications ; COVID-19/virology ; Humans ; Inflammation/complications ; Inflammation/metabolism ; Megakaryocytes/metabolism ; SARS-CoV-2/physiology ; Thrombocytosis/complications ; Thrombocytosis/metabolism ; Thrombopoiesis/genetics ; Thrombopoietin/metabolism ; Thrombosis/complications ; Thrombosis/metabolism
Czasopismo naukowe
Tytuł :
C-Cbl regulates c-MPL receptor trafficking and its internalization.
Autorzy :
Märklin M; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), German Cancer Research Centre (DKFZ), University Hospital Tübingen, Tübingen, Germany.
Tandler C; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), German Cancer Research Centre (DKFZ), University Hospital Tübingen, Tübingen, Germany.
Kopp HG; Department of Molecular Oncology and Thoracic Oncology, Robert-Bosch-Hospital Stuttgart, Stuttgart, Germany.
Hoehn KL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.
Quintanilla-Martinez L; Department of Pathology, University of Tübingen, Tübingen, Germany.
Borst O; Department of Kardiology and Angiology, University Hospital Tübingen, Tübingen, Germany.
Müller MR; Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tübingen, Tübingen, Germany.; Department of Hematology, Oncology and Immunology, Klinikum Region Hannover, KRH Klinikum Siloah, Hannover, Germany.
Saur SJ; Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tübingen, Tübingen, Germany.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2020 Nov; Vol. 24 (21), pp. 12491-12503. Date of Electronic Publication: 2020 Sep 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endocytosis*
Proto-Oncogene Proteins c-cbl/*metabolism
Receptors, Thrombopoietin/*metabolism
Animals ; Integrases/metabolism ; Lymphocytosis ; Megakaryocytes/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Protein Transport ; Signal Transduction ; Thrombocytosis ; Thrombopoiesis ; Thrombopoietin/metabolism
Czasopismo naukowe
Tytuł :
Elucidating the Mechanism of Action of the Attributed Immunomodulatory Role of Eltrombopag in Primary Immune Thrombocytopenia: An In Silico Approach.
Autorzy :
Lozano ML; Hospital General Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, CB15/00055-CIBERER, 30007 Murcia, Spain.
Segú-Vergés C; Anaxomics Biotech S.L., Diputació 237, 1°, 1a, 08007 Barcelona, Spain.
Coma M; Anaxomics Biotech S.L., Diputació 237, 1°, 1a, 08007 Barcelona, Spain.
Álvarez-Roman MT; Unidad de Trombosis y Hemostasia, Servicio de Hematología, Hospital Universitario La Paz, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Paseo de la Castellana 261, 28046 Madrid, Spain.
González-Porras JR; Unidad de Hemostasia y Trombosis, Servicio de Hematología, Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Paseo de San Vicente, 58-182, 37007 Salamanca, Spain.
Gutiérrez L; Grupo de Investigación en Plaquetas, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Departamento de Medicina, Universidad de Oviedo, 33071 Oviedo, Spain.
Valcárcel D; Servicio Hematología, Vall d´Hebron Insitute of Oncology (VHIO), Hospital Univesitario Vall d'Hebron, Universitat Autònoma de Barcelona, Centro Cellex, Natzaret, 115-117, 08035 Barcelona, Spain.
Butta N; Instituto de Investigación HospitaUniversitario La Paz (IdiPAZ), Paseo de la Castellana 261, 28046 Madrid, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 27; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 27.
Typ publikacji :
Journal Article
MeSH Terms :
Benzoates/*pharmacology
Hydrazines/*pharmacology
Immunomodulation/*drug effects
Purpura, Thrombocytopenic, Idiopathic/*etiology
Purpura, Thrombocytopenic, Idiopathic/*metabolism
Pyrazoles/*pharmacology
Receptors, Thrombopoietin/*antagonists & inhibitors
Benzoates/chemistry ; Benzoates/therapeutic use ; Biomarkers ; Disease Management ; Disease Susceptibility ; Humans ; Hydrazines/chemistry ; Hydrazines/therapeutic use ; Models, Biological ; Models, Molecular ; Molecular Targeted Therapy/methods ; Protein Interaction Mapping ; Protein Interaction Maps ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Pyrazoles/chemistry ; Pyrazoles/therapeutic use ; Receptors, Thrombopoietin/chemistry ; Receptors, Thrombopoietin/metabolism ; Signal Transduction/drug effects ; Structure-Activity Relationship ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Hemostatic changes by thrombopoietin-receptor agonists in immune thrombocytopenia patients.
Autorzy :
van Dijk WEM; Department of Hematology, Van Creveldkliniek, University Medical Centre Utrecht, Postbox 85500, 3508 GA Utrecht, The Netherlands. Electronic address: .
Brandwijk ON; Education Centre, University Medical Centre Utrecht, Utrecht University, Universiteitsweg 98, 3584 CG Utrecht, The Netherlands.
Heitink-Polle KMJ; Department of Hematology, Van Creveldkliniek, University Medical Centre Utrecht, Postbox 85500, 3508 GA Utrecht, The Netherlands.
Schutgens REG; Department of Hematology, Van Creveldkliniek, University Medical Centre Utrecht, Postbox 85500, 3508 GA Utrecht, The Netherlands. Electronic address: .
van Galen KPM; Department of Hematology, Van Creveldkliniek, University Medical Centre Utrecht, Postbox 85500, 3508 GA Utrecht, The Netherlands. Electronic address: .
Urbanus RT; Department of Hematology, Van Creveldkliniek, University Medical Centre Utrecht, Postbox 85500, 3508 GA Utrecht, The Netherlands. Electronic address: .
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Źródło :
Blood reviews [Blood Rev] 2021 May; Vol. 47, pp. 100774. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Purpura, Thrombocytopenic, Idiopathic*/drug therapy
Purpura, Thrombocytopenic, Idiopathic*/metabolism
Purpura, Thrombocytopenic, Idiopathic*/pathology
Blood Platelets/*metabolism
Hemostatics/*therapeutic use
Platelet Aggregation/*drug effects
Receptors, Thrombopoietin/*agonists
Blood Platelets/pathology ; Fibrinolysis/drug effects ; Gene Expression Regulation/drug effects ; Hemostatics/adverse effects ; Humans ; Monocytes/metabolism ; Monocytes/pathology ; P-Selectin/biosynthesis ; Plasminogen Activator Inhibitor 1/metabolism ; Platelet Membrane Glycoproteins/biosynthesis ; Receptors, Thrombopoietin/metabolism ; Thrombosis/chemically induced ; Thrombosis/metabolism ; Thrombosis/pathology
Czasopismo naukowe
Tytuł :
Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors.
Autorzy :
Cui L; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305.
Moraga I; HHMI, Stanford University School of Medicine, Stanford, CA 94305.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.; School of Life Sciences, University of Dundee, Dundee DD15EH, United Kingdom.
Lerbs T; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305.
Van Neste C; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305.
Wilmes S; School of Life Sciences, University of Dundee, Dundee DD15EH, United Kingdom.
Tsutsumi N; HHMI, Stanford University School of Medicine, Stanford, CA 94305.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.
Trotman-Grant AC; HHMI, Stanford University School of Medicine, Stanford, CA 94305.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.
Gakovic M; HHMI, Stanford University School of Medicine, Stanford, CA 94305.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.; School of Life Sciences, University of Dundee, Dundee DD15EH, United Kingdom.
Andrews S; York Biomedical Research Institute, Department of Biology, University of York, Heslington, YO10 5DD York, United Kingdom.
Gotlib J; Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305.
Darmanis S; Department of Bioengineering, School of Bioengineering and Medicine, Stanford University, Stanford, CA 94305.; Microchemistry, Proteomics, Lipidomics and NGS Department Genentech Inc., South San Francisco, CA, 94080.
Enge M; Department of Bioengineering, School of Bioengineering and Medicine, Stanford University, Stanford, CA 94305.; Department of Oncology-Pathology Karolinska Institutet, 171 64 Stockholm, Sweden.
Quake S; Department of Bioengineering, School of Bioengineering and Medicine, Stanford University, Stanford, CA 94305.
Hitchcock IS; York Biomedical Research Institute, Department of Biology, University of York, Heslington, YO10 5DD York, United Kingdom.
Piehler J; Department of Biology and Center for Cellular Nanoanalytics (CellNanOs), University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany.
Garcia KC; HHMI, Stanford University School of Medicine, Stanford, CA 94305; .; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.
Wernig G; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305; .; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 12; Vol. 118 (2).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Thrombopoietin/*metabolism
Thrombopoietin/*metabolism
Cell Differentiation/physiology ; Cell Membrane/metabolism ; Epitopes/immunology ; Hematopoiesis/drug effects ; Hematopoietic Stem Cells/metabolism ; Humans ; Ligands ; Megakaryocytes/metabolism ; Neoplasm Proteins/metabolism ; Proto-Oncogene Proteins/metabolism ; Receptors, Cytokine/metabolism ; Receptors, Thrombopoietin/immunology ; Receptors, Thrombopoietin/physiology ; Signal Transduction/physiology ; Thrombocythemia, Essential/metabolism ; Thrombopoietin/physiology
Czasopismo naukowe
Tytuł :
Phase I Dose-Finding, Safety, and Tolerability Trial of Romiplostim to Improve Platelet Recovery After UCB Transplantation.
Autorzy :
Christakopoulos GE; Departments of Oncology and Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee.
DeFor TE; Biostatistics Core, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Hage S; Division of Pediatric Blood and Marrow Transplant & Cellular Therapy, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota.
Wagner JE; Division of Pediatric Blood and Marrow Transplant & Cellular Therapy, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota.
Linden MA; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota.
Brunstein C; Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota.
Bejanyan N; H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.
Verneris MR; Division of Hematology, Oncology, and Bone Marrow Transplantation, Department of Pediatrics, University of Colorado, Aurora, Colorado.
Smith AR; Division of Pediatric Blood and Marrow Transplant & Cellular Therapy, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota. Electronic address: .
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Źródło :
Transplantation and cellular therapy [Transplant Cell Ther] 2021 Jun; Vol. 27 (6), pp. 497.e1-497.e6. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Fc*
Thrombopoietin*/adverse effects
Adult ; Blood Platelets ; Female ; Humans ; Middle Aged ; Recombinant Fusion Proteins
Czasopismo naukowe
Tytuł :
Eltrombopag second-line therapy in adult patients with primary immune thrombocytopenia in an attempt to achieve sustained remission off-treatment: results of a phase II, multicentre, prospective study.
Autorzy :
Lucchini E; S.C. Ematologia, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
Palandri F; Azienda Ospedaliero-Universitaria di Bologna, IRCCS Policlinico S.Orsola-Malpighi, DAI, Dipartimento di Oncologia e di Ematologia, Bologna, Italy.
Volpetti S; Clinica Ematologica, Centro Trapianti e Terapie Cellulari 'C. Melzi', DAME, Università degli Studi, Udine, Italy.
Vianelli N; Azienda Ospedaliero-Universitaria di Bologna, IRCCS Policlinico S.Orsola-Malpighi, DAI, Dipartimento di Oncologia e di Ematologia, Bologna, Italy.
Auteri G; Azienda Ospedaliero-Universitaria di Bologna, IRCCS Policlinico S.Orsola-Malpighi, DAI, Dipartimento di Oncologia e di Ematologia, Bologna, Italy.
Rossi E; Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico A. Gemelli IRCCS, Roma, Italy.; Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Roma, Italy.
Patriarca A; U.O. di Ematologia, AOU Maggiore della Carità, Novara, Italy.
Carli G; Hematology Department, Ospedale San Bortolo, Vicenza, Italy.
Barcellini W; UOC Ematologia, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Celli M; Hematology Unit, Infermi Hospital, Rimini, Italy.
Consoli U; UOC Ematologia ARNAS Garibaldi, Catania, Italy.
Valeri F; Regional Center for Hemorrhagic and Thrombotic Diseases, Haematology Unit, City of Health and Science University Hospital of Molinette, Turin, Italy.
Santoro C; Hematology, University Hospital Policlinico Umberto I, Rome, Italy.
Crea E; GIMEMA Foundation, Rome, Italy.
Vignetti M; GIMEMA Foundation, Rome, Italy.
Paoloni F; GIMEMA Foundation, Rome, Italy.
Gigliotti CL; Laboratory of Immunology, Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy.
Boggio E; Laboratory of Immunology, Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy.
Dianzani U; Laboratory of Immunology, Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy.
Giardini I; Clinical and Experimental Pharmacokinetics Lab, Diagnostic Medicine Dep, IRCCS Policlinico San Matteo, Pavia, Italy.
Carpenedo M; Hematology and Transplant Dept, ASST Ospedale San Gerardo di Monza, Monza, Italy.
Rodeghiero F; Hematology Project Foundation, Vicenza, Italy - affiliated to the Dept. of Hematology of the San Bortolo Hospital, Vicenza, Italy.
Fanin R; Clinica Ematologica, Centro Trapianti e Terapie Cellulari 'C. Melzi', DAME, Università degli Studi, Udine, Italy.
Zaja F; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
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Corporate Authors :
for Gruppo Italiano Malattie Ematologiche dell’Adulto (GIMEMA)
Źródło :
British journal of haematology [Br J Haematol] 2021 Apr; Vol. 193 (2), pp. 386-396. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzoates/*therapeutic use
Drug Tapering/*statistics & numerical data
Hydrazines/*therapeutic use
Purpura, Thrombocytopenic, Idiopathic/*drug therapy
Pyrazoles/*therapeutic use
Receptors, Thrombopoietin/*agonists
Adult ; Aged ; Aged, 80 and over ; Benzoates/administration & dosage ; Benzoates/toxicity ; Cytokines/immunology ; Drug Tapering/methods ; Female ; Humans ; Hydrazines/administration & dosage ; Hydrazines/toxicity ; Lymphocytes/immunology ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Pyrazoles/administration & dosage ; Pyrazoles/toxicity ; Receptors, Thrombopoietin/immunology ; Remission Induction ; Withholding Treatment/statistics & numerical data
Czasopismo naukowe
Tytuł :
Cutaneous extramedullary hematopoiesis in a patient with secondary myelofibrosis due to MPL gene mutation.
Autorzy :
Murase Y; Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takeichi T; Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tanahashi K; Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Marumo Y; Department of Hematology and Oncology, Nagoya Memorial Hospital, Nagoya, Japan.
Suzuki Y; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.
Nakamura S; Department of Pathology, Handa City Hospital, Handa, Japan.
Akiyama M; Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
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Źródło :
Journal of the European Academy of Dermatology and Venereology : JEADV [J Eur Acad Dermatol Venereol] 2021 Apr; Vol. 35 (4), pp. e257-e259. Date of Electronic Publication: 2020 Nov 22.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
Hematopoiesis, Extramedullary*
Primary Myelofibrosis*/complications
Primary Myelofibrosis*/genetics
Receptors, Thrombopoietin*/genetics
Administration, Cutaneous ; Humans ; Mutation ; Skin
Raport
Tytuł :
[Effect of rhTPO to the Proliferation and Apoptosis of Acute Myeloid Leukemia Cell Lines].
Autorzy :
Wang N; Department of Hematology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Lyu N; Department of Hematology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Min X; Department of Hematology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Wang LL; Department of Hematology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Zhu HY; Department of Hematology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China,E-mail: .
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Źródło :
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2021 Apr; Vol. 29 (2), pp. 389-394.
Typ publikacji :
Journal Article
MeSH Terms :
Leukemia, Myeloid, Acute*
Thrombopoietin*
Apoptosis ; Cell Proliferation ; Humans ; Neoplasm Proteins ; Proto-Oncogene Proteins ; Receptors, Cytokine
Czasopismo naukowe
Tytuł :
Multifaceted roles of thrombopoietin in hematopoietic stem cell regulation.
Autorzy :
Nakamura-Ishizu A; Cancer Science Institute, National University of Singapore, Singapore, Singapore.
Suda T; International Research Center for Medical Sciences, Kumamoto University, Kumamoto City, Japan.
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Źródło :
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2020 Apr; Vol. 1466 (1), pp. 51-58. Date of Electronic Publication: 2019 Jul 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Hematopoietic Stem Cells/*physiology
Thrombopoietin/*physiology
Animals ; Cell Self Renewal/physiology ; Hematopoietic Stem Cells/drug effects ; Humans ; Receptors, Thrombopoietin/physiology ; Signal Transduction/drug effects ; Thrombopoiesis/physiology ; Thrombopoietin/pharmacology
Czasopismo naukowe

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