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Wyszukujesz frazę ""TNF-Related Apoptosis-Inducing Ligand"" wg kryterium: Temat


Tytuł :
[Effect of DR4 Demethylation to the Proliferation and Apoptosis of Myeloid Leukemia K562 Cells].
Autorzy :
Zhang M; Department of Hematology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, Henan Province, China.
Cai LH; Department of Hematology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, Henan Province, China.
Yang HP; Department of Hematology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, Henan Province, China,E-mail:.
Yang XW; Department of Hematology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, Henan Province, China.
Si XH; Xinxiang Medical College, Xinxiang 453003, Henan Province, China.
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Źródło :
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2021 Apr; Vol. 29 (2), pp. 422-427.
Typ publikacji :
Journal Article
MeSH Terms :
Leukemia, Myeloid*
Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism
Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Demethylation ; Humans ; K562 Cells ; TNF-Related Apoptosis-Inducing Ligand/metabolism
Czasopismo naukowe
Tytuł :
Overcoming therapeutic efficiency limitations against TRAIL-resistant tumors using re-sensitizing agent-loaded trimeric TRAIL-presenting nanocages.
Autorzy :
Je H; Department of Chemical Engineering, School of Applied Chemical Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea.
Nam GH; Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.
Kim GB; Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
Kim W; Department of Chemical Engineering, School of Applied Chemical Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea.
Kim SR; School of Food Science and Biotechnology, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea.
Kim IS; Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea. Electronic address: .
Lee EJ; Department of Chemical Engineering, School of Applied Chemical Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea. Electronic address: .
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Źródło :
Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2021 Mar 10; Vol. 331, pp. 7-18. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neoplasms*/drug therapy
TNF-Related Apoptosis-Inducing Ligand*
Apoptosis ; Cell Line, Tumor ; Doxorubicin ; Humans ; Receptors, TNF-Related Apoptosis-Inducing Ligand
Czasopismo naukowe
Tytuł :
Cytotoxic Efficacy and Resistance Mechanism of a TRAIL and VEGFA-Peptide Fusion Protein in Colorectal Cancer Models.
Autorzy :
Kopczynski M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Statkiewicz M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Cybulska M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Kuklinska U; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Unrug-Bielawska K; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Sandowska-Markiewicz Z; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Grochowska A; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Gajewska M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Kulecka M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.; Centre for Postgraduate Medical Education, Hepatology and Clinical Oncology, Department of Gastroenterology, 01-813 Warsaw, Poland.
Ostrowski J; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.; Centre for Postgraduate Medical Education, Hepatology and Clinical Oncology, Department of Gastroenterology, 01-813 Warsaw, Poland.
Mikula M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 19; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Drug Resistance, Neoplasm/*drug effects
Recombinant Fusion Proteins/*pharmacology
TNF-Related Apoptosis-Inducing Ligand/*metabolism
Vascular Endothelial Growth Factor A/*metabolism
Animals ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Cell Line, Tumor ; Cell Membrane/metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Humans ; Mice ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; TNF-Related Apoptosis-Inducing Ligand/chemistry ; TNF-Related Apoptosis-Inducing Ligand/genetics ; Vascular Endothelial Growth Factor A/chemistry ; Vascular Endothelial Growth Factor A/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
TRAIL therapy and prospective developments for cancer treatment.
Autorzy :
Thapa B; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada. Electronic address: .
Kc R; Department of Chemical & Material Engineering, Faculty of Engineering, University of Alberta, Edmonton, AB, Canada. Electronic address: .
Uludağ H; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Department of Chemical & Material Engineering, Faculty of Engineering, University of Alberta, Edmonton, AB, Canada; Department of Biomedical Engineering, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada. Electronic address: .
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Źródło :
Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2020 Oct 10; Vol. 326, pp. 335-349. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Neoplasms*/drug therapy
Receptors, TNF-Related Apoptosis-Inducing Ligand*
Apoptosis ; Apoptosis Regulatory Proteins ; Cell Death ; Cell Line, Tumor ; Humans ; Prospective Studies ; TNF-Related Apoptosis-Inducing Ligand
Czasopismo naukowe
Tytuł :
Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy.
Autorzy :
Chen W; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.; Department of Therapeutic Discovery, Amgen Research, Thousand Oaks, CA 91320.
Mou KY; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan 11529.
Solomon P; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
Aggarwal R; Department of Medicine, University of California, San Francisco, CA 94158.
Leung KK; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
Wells JA; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158; .; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 26; Vol. 118 (4).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Bispecific/*pharmacology
B-Lymphocytes/*drug effects
B7 Antigens/*genetics
Epithelial Cells/*drug effects
Proto-Oncogene Proteins c-myc/*genetics
Receptors, TNF-Related Apoptosis-Inducing Ligand/*genetics
Antibodies, Bispecific/biosynthesis ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; B7 Antigens/antagonists & inhibitors ; B7 Antigens/immunology ; Cell Engineering/methods ; Cell Line, Tumor ; Cytarabine/pharmacology ; Epithelial Cells/immunology ; Epithelial Cells/pathology ; Gene Expression Regulation, Neoplastic ; Humans ; Immunosuppressive Agents/pharmacology ; Immunotherapy/methods ; Male ; Molecular Targeted Therapy/methods ; Plasmids/chemistry ; Plasmids/metabolism ; Prostate/immunology ; Prostate/pathology ; Protein Binding ; Proto-Oncogene Proteins c-myc/immunology ; Receptors, TNF-Related Apoptosis-Inducing Ligand/antagonists & inhibitors ; Receptors, TNF-Related Apoptosis-Inducing Ligand/immunology ; Signal Transduction ; TNF-Related Apoptosis-Inducing Ligand/pharmacology ; Transfection
Czasopismo naukowe
Tytuł :
Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides.
Autorzy :
Wang Y; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Baars I; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Fördös F; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Högberg B; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
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Źródło :
ACS nano [ACS Nano] 2021 Jun 22; Vol. 15 (6), pp. 9614-9626. Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, TNF-Related Apoptosis-Inducing Ligand*
TNF-Related Apoptosis-Inducing Ligand*
Apoptosis ; Cluster Analysis ; Humans ; Peptides ; Tumor Necrosis Factor-alpha
Czasopismo naukowe
Tytuł :
Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats.
Autorzy :
Wang Y; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Zhang H; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Wang Z; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Wei Y; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Wang M; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Liu M; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Wang X; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.; Henan University affiliated Huaihe Hospital, Kaifeng 475004, P.R. China.
Jiang Y; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Shi G; Henan University affiliated Huaihe Hospital, Kaifeng 475004, P.R. China.
Zhao D; Henan University affiliated Huaihe Hospital, Kaifeng 475004, P.R. China.
Yang Z; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Ren Z; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Li J; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Zhang Z; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Wang Z; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Zhang B; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Zong B; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Lou X; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Liu C; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Wang Z; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Zhang H; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Tao N; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Li X; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Zhang X; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Guo Y; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Ye Y; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Qi Y; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Li H; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Wang M; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Guo R; Henan University affiliated Huaihe Hospital, Kaifeng 475004, P.R. China.
Cheng G; Henan University affiliated Huaihe Hospital, Kaifeng 475004, P.R. China.
Li S; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Zhang J; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Liu G; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Chai L; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Lou Q; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Li X; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Cui X; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Gao E; Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Dong Z; Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center, Augusta, GA 30912, USA.
Hu Y; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China.
Chen YH; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. .
Ma Y; Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cell and Molecular Immunology, School of Medical Sciences, Henan University, Kaifeng 475004, P.R. China. .
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Źródło :
Science translational medicine [Sci Transl Med] 2020 Apr 22; Vol. 12 (540).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Myocardial Infarction*/drug therapy
Receptors, TNF-Related Apoptosis-Inducing Ligand*
Animals ; Apoptosis ; Cell Line, Tumor ; Haplorhini ; Rats ; Swine ; TNF-Related Apoptosis-Inducing Ligand
Czasopismo naukowe
Tytuł :
TRAIL-Armed ER Nanosomes Induce Drastically Enhanced Apoptosis in Resistant Tumor in Combination with the Antagonist of IAPs (AZD5582).
Autorzy :
Hou H; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
Su K; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
Huang C; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
Yuan Q; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
Li S; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
Sun J; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
Lin Y; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
Du Z; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
Ke C; YZ Health-tech Inc., Hengqin District, Zhuhai, 519000, China.; School of Pharmacy, Jinan University, Guangzhou, 510632, China.
Yuan Z; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 51006, China.
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Źródło :
Advanced healthcare materials [Adv Healthc Mater] 2021 Jun; Vol. 10 (11), pp. e2100030. Date of Electronic Publication: 2021 May 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neoplasms*
TNF-Related Apoptosis-Inducing Ligand*
Alkynes ; Apoptosis ; Cell Line, Tumor ; Endoplasmic Reticulum ; Humans ; Oligopeptides
Czasopismo naukowe
Tytuł :
Andrographolide sensitizes human renal carcinoma cells to TRAIL‑induced apoptosis through upregulation of death receptor 4.
Autorzy :
Bi R; Department of Urology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Deng Y; Department of Urology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Tang C; Department of Urology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Xuan L; Department of Urology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Xu B; Department of Urology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Du Y; Department of Nephrology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Wang C; Department of Urology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Wei W; Key Laboratory of Organ Regeneration and Transplantation of The Ministry of Education, Institute of Translational Medicine, Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, Jilin 130061, P.R. China.
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Źródło :
Oncology reports [Oncol Rep] 2020 Nov; Vol. 44 (5), pp. 1939-1948. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Carcinoma, Renal Cell/*drug therapy
Diterpenes/*pharmacology
Kidney Neoplasms/*drug therapy
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Apoptosis/drug effects ; Carcinoma, Renal Cell/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Diterpenes/therapeutic use ; Drug Screening Assays, Antitumor ; Drug Synergism ; G2 Phase Cell Cycle Checkpoints/drug effects ; Gene Knockdown Techniques ; Humans ; Kidney Neoplasms/pathology ; Proof of Concept Study ; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; Recombinant Proteins/pharmacology ; Recombinant Proteins/therapeutic use ; Signal Transduction/drug effects ; Signal Transduction/genetics ; TNF-Related Apoptosis-Inducing Ligand/therapeutic use ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Noncompetitive Allosteric Antagonism of Death Receptor 5 by a Synthetic Affibody Ligand.
Autorzy :
Vunnam N; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Szymonski S; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Hirsova P; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, United States.
Gores GJ; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, United States.
Sachs JN; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Hackel BJ; Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, United States.
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Źródło :
Biochemistry [Biochemistry] 2020 Oct 13; Vol. 59 (40), pp. 3856-3868. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Apoptosis/*drug effects
Peptides/*chemistry
Peptides/*pharmacology
Receptors, TNF-Related Apoptosis-Inducing Ligand/*antagonists & inhibitors
Cell Line, Tumor ; Drug Discovery ; HEK293 Cells ; Hepatocytes/cytology ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Humans ; Ligands ; Protein Multimerization/drug effects ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; TNF-Related Apoptosis-Inducing Ligand/metabolism
Czasopismo naukowe
Tytuł :
TRAIL treatment prevents renal morphological changes and TGF-β-induced mesenchymal transition associated with diabetic nephropathy.
Autorzy :
Toffoli B; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Via dell'Istria 65, Trieste 34100, Italy.
Tonon F; Department of Medical, Surgical and Health Sciences, University of Trieste, Cattinara Teaching Hospital, Strada di Fiume 447, Trieste 34100, Italy.
Tisato V; Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Via Fossato di Mortara 66, Ferrara 44100, Italy.
Michelli A; Department of Medical, Surgical and Health Sciences, University of Trieste, Cattinara Teaching Hospital, Strada di Fiume 447, Trieste 34100, Italy.
Zauli G; Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Via Fossato di Mortara 66, Ferrara 44100, Italy.
Secchiero P; Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Via Fossato di Mortara 66, Ferrara 44100, Italy.
Fabris B; Department of Medical, Surgical and Health Sciences, University of Trieste, Cattinara Teaching Hospital, Strada di Fiume 447, Trieste 34100, Italy.
Bernardi S; Department of Medical, Surgical and Health Sciences, University of Trieste, Cattinara Teaching Hospital, Strada di Fiume 447, Trieste 34100, Italy.
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Źródło :
Clinical science (London, England : 1979) [Clin Sci (Lond)] 2020 Sep 18; Vol. 134 (17), pp. 2337-2352.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial-Mesenchymal Transition*/drug effects
Diabetic Nephropathies/*pathology
Kidney/*pathology
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Transforming Growth Factor beta/*pharmacology
Animals ; Body Weight/drug effects ; Diabetic Nephropathies/metabolism ; Feeding Behavior/drug effects ; Fibrosis ; Gene Expression Regulation/drug effects ; Gene Silencing/drug effects ; Glucose/metabolism ; Humans ; Inflammation/pathology ; Kidney/drug effects ; Kidney/physiopathology ; Kidney Tubules/drug effects ; Kidney Tubules/pathology ; Kidney Tubules/physiopathology ; Male ; Mice ; Protein Binding/drug effects ; Rats ; Receptors, Leptin/metabolism ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; Sequestosome-1 Protein/metabolism
Czasopismo naukowe
Tytuł :
HTNV Sensitizes Host Toward TRAIL-Mediated Apoptosis-A Pivotal Anti-hantaviral Role of TRAIL.
Autorzy :
Chen QZ; State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy & Immunology, School of Basic Medical Sciences, Institute of Medical Virology, Wuhan University, Wuhan, China.
Wang X; State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy & Immunology, School of Basic Medical Sciences, Institute of Medical Virology, Wuhan University, Wuhan, China.
Luo F; State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy & Immunology, School of Basic Medical Sciences, Institute of Medical Virology, Wuhan University, Wuhan, China.
Li N; State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy & Immunology, School of Basic Medical Sciences, Institute of Medical Virology, Wuhan University, Wuhan, China.
Zhu N; Department of Microbiology, School of Basic Medical Sciences, Hubei University of Science and Technology, Xianning, China.
Lu S; State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy & Immunology, School of Basic Medical Sciences, Institute of Medical Virology, Wuhan University, Wuhan, China.
Zan YX; State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy & Immunology, School of Basic Medical Sciences, Institute of Medical Virology, Wuhan University, Wuhan, China.
Zhong CJ; State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy & Immunology, School of Basic Medical Sciences, Institute of Medical Virology, Wuhan University, Wuhan, China.
Wang MR; State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy & Immunology, School of Basic Medical Sciences, Institute of Medical Virology, Wuhan University, Wuhan, China.
Hu HT; Department of Microbiology & Immunology and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX, United States.
Zhang YZ; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, National Institute for Communicable Disease Control and Prevention, Beijing, China.
Xiong HR; State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy & Immunology, School of Basic Medical Sciences, Institute of Medical Virology, Wuhan University, Wuhan, China.
Hou W; State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy & Immunology, School of Basic Medical Sciences, Institute of Medical Virology, Wuhan University, Wuhan, China.; Department of Microbiology, School of Basic Medical Sciences, Hubei University of Science and Technology, Xianning, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Jun 19; Vol. 11, pp. 1072. Date of Electronic Publication: 2020 Jun 19 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*immunology
Hantaan virus/*immunology
Hantaan virus/*pathogenicity
Host Microbial Interactions/*immunology
TNF-Related Apoptosis-Inducing Ligand/*immunology
Animals ; Animals, Suckling ; Disease Models, Animal ; Female ; Hemorrhagic Fever with Renal Syndrome/immunology ; Hemorrhagic Fever with Renal Syndrome/therapy ; Hemorrhagic Fever with Renal Syndrome/virology ; Human Umbilical Vein Endothelial Cells ; Humans ; Interferon-beta/biosynthesis ; Mice ; Mice, Inbred BALB C ; Pregnancy ; RNA, Small Interfering/genetics ; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Recombinant Proteins/therapeutic use ; TNF-Related Apoptosis-Inducing Ligand/genetics ; TNF-Related Apoptosis-Inducing Ligand/therapeutic use ; Viral Load/immunology ; Virus Replication
Czasopismo naukowe
Tytuł :
Multiple Interactions Between Cancer Cells and the Tumor Microenvironment Modulate TRAIL Signaling: Implications for TRAIL Receptor Targeted Therapy.
Autorzy :
de Looff M; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
de Jong S; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Kruyt FAE; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
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Źródło :
Frontiers in immunology [Front Immunol] 2019 Jul 03; Vol. 10, pp. 1530. Date of Electronic Publication: 2019 Jul 03 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cell Communication*/drug effects
Cell Communication*/immunology
Neoplasms*/drug therapy
Neoplasms*/immunology
Neoplasms*/pathology
Signal Transduction*/drug effects
Signal Transduction*/immunology
TNF-Related Apoptosis-Inducing Ligand*/immunology
TNF-Related Apoptosis-Inducing Ligand*/therapeutic use
Tumor Microenvironment/*immunology
Humans ; Receptors, TNF-Related Apoptosis-Inducing Ligand/immunology
Czasopismo naukowe
Tytuł :
ATF3 Promotes Arsenic-Induced Apoptosis and Oppositely Regulates DR5 and Bcl-xL Expression in Human Bronchial Epithelial Cells.
Autorzy :
Shi Q; Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Institute of Engineering Biology and Health, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Hu B; Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Institute of Engineering Biology and Health, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Yang C; Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Institute of Engineering Biology and Health, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Zhao L; Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Institute of Engineering Biology and Health, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Wu J; Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Institute of Engineering Biology and Health, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Qi N; Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Institute of Engineering Biology and Health, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 19; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 19.
Typ publikacji :
Journal Article
MeSH Terms :
Activating Transcription Factor 3/*metabolism
Arsenic/*toxicity
Bronchi/*cytology
Epithelial Cells/*drug effects
Epithelial Cells/*metabolism
Receptors, TNF-Related Apoptosis-Inducing Ligand/*metabolism
Activating Transcription Factor 3/genetics ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; Humans ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/genetics ; Promoter Regions, Genetic/drug effects ; Promoter Regions, Genetic/genetics ; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics
Czasopismo naukowe
Tytuł :
Downregulation of death receptor 4 is tightly associated with positive response of EGFR mutant lung cancer to EGFR-targeted therapy and improved prognosis.
Autorzy :
Zhang S; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia, USA.
Chen Z; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia, USA.
Shi P; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia, USA.
Fan S; Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
He Y; Department of Respiratory Disease, Daping Hospital, Chongqing, China.
Wang Q; Department of Internal Medicine, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China.
Li Y; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia, USA.
Ramalingam SS; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia, USA.
Owonikoko TK; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia, USA.
Sun SY; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia, USA.
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Źródło :
Theranostics [Theranostics] 2021 Feb 15; Vol. 11 (8), pp. 3964-3980. Date of Electronic Publication: 2021 Feb 15 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, erbB-1*
Carcinoma, Non-Small-Cell Lung/*genetics
Carcinoma, Non-Small-Cell Lung/*therapy
Lung Neoplasms/*genetics
Lung Neoplasms/*therapy
Receptors, TNF-Related Apoptosis-Inducing Ligand/*genetics
Receptors, TNF-Related Apoptosis-Inducing Ligand/*metabolism
Acrylamides/pharmacology ; Aniline Compounds/pharmacology ; Animals ; Apoptosis/drug effects ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Line, Tumor ; Down-Regulation ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Gene Knockdown Techniques ; Humans ; Lung Neoplasms/metabolism ; Mice ; Molecular Targeted Therapy ; Mutation ; Precision Medicine ; Prognosis ; Protein Kinase Inhibitors/pharmacology ; Receptors, TNF-Related Apoptosis-Inducing Ligand/antagonists & inhibitors ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
TRAIL in oncology: From recombinant TRAIL to nano- and self-targeted TRAIL-based therapies.
Autorzy :
Dianat-Moghadam H; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Heidarifard M; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mahari A; Department of Chemical Engineering, Islamic Azad University, Ahar Branch, Ahar, Iran.
Shahgolzari M; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Keshavarz M; The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
Nouri M; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Amoozgar Z; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: .
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Źródło :
Pharmacological research [Pharmacol Res] 2020 May; Vol. 155, pp. 104716. Date of Electronic Publication: 2020 Feb 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Neoplasms/*metabolism
TNF-Related Apoptosis-Inducing Ligand/*metabolism
Animals ; Humans ; Molecular Targeted Therapy ; Nanomedicine ; Neoplasms/drug therapy ; Receptors, TNF-Related Apoptosis-Inducing Ligand ; Recombinant Proteins/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Acid/bile exposure triggers TRAIL-mediated apoptosis in esophageal cancer cells by suppressing the decoy receptors and c-FLIP R .
Autorzy :
Meng X; Inner Mongolia Institute of Digestive Diseases, The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, 30 Hudemulin Rd, Baotou, 014030, China.
Chang Z; Inner Mongolia Institute of Digestive Diseases, The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, 30 Hudemulin Rd, Baotou, 014030, China; The First Affiliated Hospital of Soochow University, 188 Ten Zi St, Suzhou, China.
Che N; Inner Mongolia Institute of Digestive Diseases, The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, 30 Hudemulin Rd, Baotou, 014030, China.
Wu J; Inner Mongolia Institute of Digestive Diseases, The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, 30 Hudemulin Rd, Baotou, 014030, China.
Dang T; Inner Mongolia Institute of Digestive Diseases, The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, 30 Hudemulin Rd, Baotou, 014030, China. Electronic address: .
Chai J; Inner Mongolia Institute of Digestive Diseases, The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, 30 Hudemulin Rd, Baotou, 014030, China; Laboratory of Gastrointestinal Injury and Cancer, VA Long Beach Healthcare System, Long Beach, CA 90822, USA; College of Medicine, University of California, Irvine, CA, 92697, USA. Electronic address: .
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Źródło :
The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2020 May; Vol. 122, pp. 105736. Date of Electronic Publication: 2020 Mar 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma/*metabolism
Adenocarcinoma/*pathology
Bile Acids and Salts/*pharmacology
CASP8 and FADD-Like Apoptosis Regulating Protein/*antagonists & inhibitors
Esophageal Neoplasms/*metabolism
Esophageal Neoplasms/*pathology
TNF-Related Apoptosis-Inducing Ligand/*metabolism
Tumor Necrosis Factor Decoy Receptors/*antagonists & inhibitors
Apoptosis/drug effects ; CASP8 and FADD-Like Apoptosis Regulating Protein/metabolism ; Cell Line, Tumor ; Gastroesophageal Reflux/chemically induced ; Gastroesophageal Reflux/metabolism ; Gastroesophageal Reflux/pathology ; Humans ; Hydrochloric Acid/pharmacology ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; Transfection ; Tumor Necrosis Factor Decoy Receptors/metabolism
SCR Disease Name :
Adenocarcinoma Of Esophagus
Czasopismo naukowe
Tytuł :
Micelle-in-Liposomes for Sustained Delivery of Anticancer Agents That Promote Potent TRAIL-Induced Cancer Cell Apoptosis.
Autorzy :
Zhang Z; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212, USA.
Patel SB; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212, USA.
King MR; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Dec 31; Vol. 26 (1). Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Micelles*
Antineoplastic Agents/*pharmacology
Dioxolanes/*pharmacology
Liposomes/*chemistry
Prostatic Neoplasms/*drug therapy
TNF-Related Apoptosis-Inducing Ligand/*metabolism
Antineoplastic Agents/chemistry ; Apoptosis ; Drug Synergism ; Humans ; Male ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; TNF-Related Apoptosis-Inducing Ligand/administration & dosage ; TNF-Related Apoptosis-Inducing Ligand/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
PDGFRβ-targeted TRAIL specifically induces apoptosis of activated hepatic stellate cells and ameliorates liver fibrosis.
Autorzy :
Li R; Key Lab of Transplant Engineering and Immunology, MOH; Regenerative Medical Research Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Li Z; Key Lab of Transplant Engineering and Immunology, MOH; Regenerative Medical Research Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Feng Y; Key Lab of Transplant Engineering and Immunology, MOH; Regenerative Medical Research Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Yang H; Key Lab of Transplant Engineering and Immunology, MOH; Regenerative Medical Research Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Shi Q; Key Lab of Transplant Engineering and Immunology, MOH; Regenerative Medical Research Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Tao Z; Key Lab of Transplant Engineering and Immunology, MOH; Regenerative Medical Research Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Cheng J; Key Lab of Transplant Engineering and Immunology, MOH; Regenerative Medical Research Center, West China Hospital, Sichuan University, Chengdu, 610041, China. .
Lu X; Key Lab of Transplant Engineering and Immunology, MOH; Regenerative Medical Research Center, West China Hospital, Sichuan University, Chengdu, 610041, China. .
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Źródło :
Apoptosis : an international journal on programmed cell death [Apoptosis] 2020 Feb; Vol. 25 (1-2), pp. 105-119.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hepatic Stellate Cells/*metabolism
Liver Cirrhosis/*metabolism
Receptor, Platelet-Derived Growth Factor beta/*metabolism
TNF-Related Apoptosis-Inducing Ligand/*metabolism
Animals ; Apoptosis ; Cell Line, Tumor ; Extracellular Matrix/genetics ; Extracellular Matrix/metabolism ; Female ; Hepatic Stellate Cells/cytology ; Humans ; Liver Cirrhosis/genetics ; Liver Cirrhosis/physiopathology ; Mice ; Mice, Inbred C57BL ; Receptor, Platelet-Derived Growth Factor beta/genetics ; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; TNF-Related Apoptosis-Inducing Ligand/genetics
Czasopismo naukowe
Tytuł :
Novel regulator role of CIL-102 in the epigenetic modification of TNFR1/TRAIL to induce cell apoptosis in human gastric cancer.
Autorzy :
Teng CC; Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chiayi, Taiwan; Chang Gung Memorial Hospital, Chiayi, Taiwan.
Tung SY; Department of Hepato-Gastroenterology, Chang Gung Memorial Hospital, Chiayi, Taiwan; Chang Gung University College of Medicine, Taoyuan, Taiwan.
Lee KC; Division of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Department of Information Management & College of Liberal Education, Shu-Te University, Kaohsiung, Taiwan.
Lee KF; Department of Pathology, Chang Gung Memorial Hospital at Chiayi, Taiwan.
Huang WS; Chang Gung University College of Medicine, Taoyuan, Taiwan; Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital Chiayi, Taiwan.
Shen CH; Department of Hepato-Gastroenterology, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Hsieh MC; Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital Chiayi, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taiwan.
Huang CY; Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital Chiayi, Taiwan.
Sheen JM; Department of Pediatrics, Chiayi Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Chiayi, Taiwan.
Kuo HC; Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chiayi, Taiwan; Chang Gung Memorial Hospital, Chiayi, Taiwan; Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Chronic Diseases and Health Promotion Research Center, CGUST, Chiayi, Taiwan. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2021 Jan; Vol. 147, pp. 111856. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Epigenesis, Genetic/*drug effects
Quinolines/*pharmacology
Receptors, Tumor Necrosis Factor, Type I/*metabolism
Stomach Neoplasms/*metabolism
TNF-Related Apoptosis-Inducing Ligand/*metabolism
Animals ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Gene Expression Regulation, Neoplastic/drug effects ; Histones/genetics ; Histones/metabolism ; Humans ; Methylation ; Mice ; Mice, Nude ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Quinolines/administration & dosage ; Quinolines/chemistry ; Receptors, Tumor Necrosis Factor, Type I/genetics ; Stomach Neoplasms/pathology ; TNF-Related Apoptosis-Inducing Ligand/genetics ; Up-Regulation/drug effects
Czasopismo naukowe

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