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Wyszukujesz frazę ""TOR Serine-Threonine Kinases"" wg kryterium: Temat


Tytuł :
Prevention of Akt phosphorylation is a key to targeting cancer stem-like cells by mTOR inhibition.
Autorzy :
Matsubara S; Division of Cancer and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan. .; Center for Advanced Biomedical Science and Swine Research, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan. .
Tsukasa K; Division of Cancer and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.; Center for Advanced Biomedical Science and Swine Research, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
Kuwahata T; Division of Cancer and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.; Center for Advanced Biomedical Science and Swine Research, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
Takao S; Division of Cancer and Regenerative Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.; Center for Advanced Biomedical Science and Swine Research, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.; Tanegashima Medical Center, 7463, Nishino-omote, 891-3198, Japan.
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Źródło :
Human cell [Hum Cell] 2020 Oct; Vol. 33 (4), pp. 1197-1203. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article
MeSH Terms :
Morpholines/*pharmacology
Neoplastic Stem Cells/*pathology
Pancreatic Neoplasms/*genetics
Pancreatic Neoplasms/*pathology
Proto-Oncogene Proteins c-akt/*metabolism
Pyrimidines/*pharmacology
TOR Serine-Threonine Kinases/*genetics
TOR Serine-Threonine Kinases/*metabolism
AC133 Antigen/genetics ; AC133 Antigen/metabolism ; Gene Expression ; Humans ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/genetics ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Phosphorylation/drug effects ; Phosphorylation/genetics ; Signal Transduction/drug effects ; Signal Transduction/genetics ; TOR Serine-Threonine Kinases/physiology ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Prokineticin 2 relieves hypoxia/reoxygenation-induced injury through activation of Akt/mTOR pathway in H9c2 cardiomyocytes.
Autorzy :
Su G; Department of Cardiac Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Sun G; Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Liu H; Department of Cardiac Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Shu L; Department of Cardiac Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhang W; Department of Cardiac Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Liang Z; Department of Cardiac Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 345-352.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Signal Transduction*
Gastrointestinal Hormones/*metabolism
Myocardial Reperfusion Injury/*metabolism
Myocytes, Cardiac/*metabolism
Neuropeptides/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Animals ; Cell Line ; Gastrointestinal Hormones/genetics ; Myocardial Reperfusion Injury/genetics ; Myocardial Reperfusion Injury/pathology ; Myocytes, Cardiac/pathology ; Neuropeptides/genetics ; Oxidative Stress ; Proto-Oncogene Proteins c-akt/genetics ; Rats ; TOR Serine-Threonine Kinases/genetics
Czasopismo naukowe
Tytuł :
eIF4G-driven translation initiation of downstream ORFs in mammalian cells.
Autorzy :
Nobuta R; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Machida K; Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo, Himeji 671-2280, Japan.
Sato M; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Hashimoto S; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Toriumi Y; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Nakajima S; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Suto D; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Imataka H; Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo, Himeji 671-2280, Japan.
Inada T; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10441-10455.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Eukaryotic Initiation Factor-4G/*genetics
GTP Cyclohydrolase/*genetics
Open Reading Frames/*genetics
TOR Serine-Threonine Kinases/*genetics
3' Untranslated Regions/genetics ; Eukaryotic Initiation Factor-4E/genetics ; Humans ; Naphthyridines/pharmacology ; Poliovirus/genetics ; Protein Biosynthesis/genetics ; RNA Caps/genetics ; RNA, Messenger/genetics ; RNA, Ribosomal, 18S/genetics ; Ribosomes/genetics ; TOR Serine-Threonine Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
FGF Expression in HPV16-positive and -negative SCC After Treatment With Small-molecule Tyrosine Kinase Inhibitors and Everolimus.
Autorzy :
Huber L; Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany .
Birk R; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, University of Marburg, Marburg, Germany.
Knuettel M; Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Rotter N; Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Aderhold C; Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Scherl C; Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Lammert A; Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Jungbauer F; Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Kramer B; Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
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Źródło :
Anticancer research [Anticancer Res] 2020 Oct; Vol. 40 (10), pp. 5621-5630.
Typ publikacji :
Journal Article
MeSH Terms :
Everolimus/*pharmacology
Fibroblast Growth Factors/*genetics
Squamous Cell Carcinoma of Head and Neck/*drug therapy
TOR Serine-Threonine Kinases/*genetics
Cell Line, Tumor ; Dasatinib/pharmacology ; Erlotinib Hydrochloride/pharmacology ; Fibroblast Growth Factors/antagonists & inhibitors ; Gefitinib/pharmacology ; Human papillomavirus 16/drug effects ; Human papillomavirus 16/pathogenicity ; Humans ; Papillomaviridae/drug effects ; Papillomaviridae/pathogenicity ; Protein Kinase Inhibitors/pharmacology ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/pathology ; Squamous Cell Carcinoma of Head and Neck/virology ; TOR Serine-Threonine Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
LIN28B/ let-7 control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling.
Autorzy :
Li XJ; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Doetzlhofer A; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205; .; The Center for Hearing and Balance, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 08; Vol. 117 (36), pp. 22225-22236. Date of Electronic Publication: 2020 Aug 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Hair Cells, Auditory/*physiology
Labyrinth Supporting Cells/*metabolism
MicroRNAs/*metabolism
RNA-Binding Proteins/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Animals ; Gene Expression Regulation, Developmental ; Genotype ; Mice ; MicroRNAs/genetics ; Organoids ; RNA-Binding Proteins/genetics ; TOR Serine-Threonine Kinases/genetics
Czasopismo naukowe
Tytuł :
Obesity and COVID-19: The mTOR pathway as a possible culprit.
Autorzy :
Bolourian A; College of Pharmacy, Oregon State University, Corvallis, Oregon, USA.
Mojtahedi Z; Department of Health Care Administration and Policy, School of Public Health, University of Nevada, Las Vegas, Las Vegas, Nevada, USA.
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Źródło :
Obesity reviews : an official journal of the International Association for the Study of Obesity [Obes Rev] 2020 Sep; Vol. 21 (9), pp. e13084. Date of Electronic Publication: 2020 Jun 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Betacoronavirus/*metabolism
Coronavirus Infections/*complications
Coronavirus Infections/*metabolism
Obesity/*complications
Pneumonia, Viral/*complications
Pneumonia, Viral/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Genetic Predisposition to Disease/genetics ; Humans ; Obesity/genetics ; Obesity/metabolism ; Pandemics ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Involvement of mTOR-related signaling in antidepressant effects of Sophoraflavanone G on chronically stressed mice.
Autorzy :
Wang H; College of Pharmacy, Ningxia Medical University, Yinchuan, China.; Ningxia Research Center of Modern Hui Medicine Engineering and Technology, Ningxia Medical University, Yinchuan, China.; Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, China.
Tong Y; College of Pharmacy, Ningxia Medical University, Yinchuan, China.
Xiao D; College of Pharmacy, Ningxia Medical University, Yinchuan, China.
Xia B; Faculty of Rehabilitation Science, Nanjing Normal University of Special Education, Nanjing, China.
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Źródło :
Phytotherapy research : PTR [Phytother Res] 2020 Sep; Vol. 34 (9), pp. 2246-2257. Date of Electronic Publication: 2020 Apr 03.
Typ publikacji :
Journal Article
MeSH Terms :
Antidepressive Agents/*pharmacology
Flavanones/*pharmacology
Stress, Psychological/*pathology
TOR Serine-Threonine Kinases/*physiology
Animals ; Behavior, Animal/drug effects ; Chronic Disease ; Depression/drug therapy ; Depression/metabolism ; Disease Models, Animal ; Food Preferences/drug effects ; Hindlimb Suspension ; Hippocampus/drug effects ; Male ; Mice ; Mice, Inbred BALB C ; Signal Transduction/drug effects ; Sirolimus/pharmacology ; Stress, Psychological/metabolism ; Sucrose/administration & dosage ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Cu(II) disrupts autophagy-mediated lysosomal degradation of oligomeric Aβ in microglia via mTOR-TFEB pathway.
Autorzy :
Tan X; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
Guan H; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
Yang Y; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
Luo S; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
Hou L; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
Chen H; Institute of Interdisciplinary Integrative Biomedical Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201210, China.
Li J; Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Aug 15; Vol. 401, pp. 115090. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/*metabolism
Copper/*toxicity
Lysosomes/*metabolism
Microglia/*metabolism
Peptide Fragments/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Amyloid beta-Peptides/antagonists & inhibitors ; Animals ; Animals, Newborn ; Autophagy/drug effects ; Autophagy/physiology ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/antagonists & inhibitors ; Cell Line ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Lysosomes/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Microglia/drug effects ; Peptide Fragments/antagonists & inhibitors ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Signal Transduction/physiology ; TOR Serine-Threonine Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Ovatodiolide, isolated from Anisomeles indica, suppresses bladder carcinogenesis through suppression of mTOR/β-catenin/CDK6 and exosomal miR-21 derived from M2 tumor-associated macrophages.
Autorzy :
Wu ATH; The PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114, Taiwan.
Srivastava P; The PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan; The Program for Translational Medicine, Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Yadav VK; The Program for Translational Medicine, Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Tzeng DTW; School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Iamsaard S; Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand; Research Institute for Human High Performance and Health Promotion (HHP&HP), Khon Kaen University, Khon Kaen, Thailand.
Su EC; Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Hsiao M; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan; Department of Biochemistry, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Liu MC; Department of Urology, Taipei Medical University Hospital, Taipei 11031, Taiwan; Clinical Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan; Graduate Institute of Clinical Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan; School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Aug 15; Vol. 401, pp. 115109. Date of Electronic Publication: 2020 Jun 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cyclin-Dependent Kinase 6/*metabolism
Diterpenes/*therapeutic use
MicroRNAs/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Urinary Bladder Neoplasms/*metabolism
beta Catenin/*metabolism
Animals ; Carcinogenesis/drug effects ; Carcinogenesis/metabolism ; Cell Line, Tumor ; Coculture Techniques ; Cyclin-Dependent Kinase 6/antagonists & inhibitors ; Diterpenes/isolation & purification ; Diterpenes/pharmacology ; Dose-Response Relationship, Drug ; Exosomes/drug effects ; Exosomes/metabolism ; Exosomes/pathology ; Female ; Humans ; Macrophages/drug effects ; Macrophages/metabolism ; Macrophages/pathology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; MicroRNAs/antagonists & inhibitors ; Plants, Medicinal ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/pathology ; beta Catenin/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Use of De Novo mTOR Inhibitors in Hypersensitized Kidney Transplant Recipients: Experience From Clinical Practice.
Autorzy :
Cucchiari D; Nephrology and Renal Transplant Department, Hospital Clínic, Barcelona, Spain.
Molina-Andujar A; Nephrology and Renal Transplant Department, Hospital Clínic, Barcelona, Spain.
Montagud-Marrahi E; Nephrology and Renal Transplant Department, Hospital Clínic, Barcelona, Spain.
Revuelta I; Nephrology and Renal Transplant Department, Hospital Clínic, Barcelona, Spain.; Laboratori Experimental de Nefrologia I Trasplantament (LENIT), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Red de Investigación Renal (REDINREN), Madrid, Spain.
Rovira J; Laboratori Experimental de Nefrologia I Trasplantament (LENIT), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Red de Investigación Renal (REDINREN), Madrid, Spain.
Ventura-Aguiar P; Nephrology and Renal Transplant Department, Hospital Clínic, Barcelona, Spain.
Piñeiro GJ; Nephrology and Renal Transplant Department, Hospital Clínic, Barcelona, Spain.
De Sousa-Amorim E; Nephrology and Renal Transplant Department, Hospital Clínic, Barcelona, Spain.
Esforzado N; Nephrology and Renal Transplant Department, Hospital Clínic, Barcelona, Spain.
Cofán F; Nephrology and Renal Transplant Department, Hospital Clínic, Barcelona, Spain.
Torregrosa JV; Nephrology and Renal Transplant Department, Hospital Clínic, Barcelona, Spain.
Ugalde-Altamirano J; Nephrology and Renal Transplant Department, Hospital Clínic, Barcelona, Spain.
Ricart MJ; Nephrology and Renal Transplant Department, Hospital Clínic, Barcelona, Spain.
Centellas-Pérez FJ; Complejo Hospitalario Universitario, Albacete, Spain.
Solè M; Department of Pathology, Hospital Clínic, Barcelona, Spain.
Martorell J; Department of Immunology, Hospital Clínic, Barcelona, Spain.
Ríos J; Medical Statistics Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and Hospital Clínic, Barcelona, Spain.; Biostatistics Unit, Faculty of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Campistol JM; Nephrology and Renal Transplant Department, Hospital Clínic, Barcelona, Spain.; Laboratori Experimental de Nefrologia I Trasplantament (LENIT), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Diekmann F; Nephrology and Renal Transplant Department, Hospital Clínic, Barcelona, Spain.; Laboratori Experimental de Nefrologia I Trasplantament (LENIT), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Red de Investigación Renal (REDINREN), Madrid, Spain.
Oppenheimer F; Nephrology and Renal Transplant Department, Hospital Clínic, Barcelona, Spain.
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Źródło :
Transplantation [Transplantation] 2020 Aug; Vol. 104 (8), pp. 1686-1694.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Desensitization, Immunologic/*methods
Graft Rejection/*prevention & control
Immunosuppressive Agents/*administration & dosage
Kidney Transplantation/*adverse effects
TOR Serine-Threonine Kinases/*antagonists & inhibitors
Adult ; Aged ; Calcineurin Inhibitors/administration & dosage ; Calcineurin Inhibitors/adverse effects ; Desensitization, Immunologic/adverse effects ; Drug Therapy, Combination/adverse effects ; Drug Therapy, Combination/methods ; Everolimus/administration & dosage ; Everolimus/adverse effects ; Female ; Glucocorticoids/administration & dosage ; Glucocorticoids/adverse effects ; Graft Rejection/immunology ; HLA Antigens/immunology ; Humans ; Immunosuppressive Agents/adverse effects ; Isoantibodies/immunology ; Male ; Middle Aged ; Mycophenolic Acid/administration & dosage ; Mycophenolic Acid/adverse effects ; Retrospective Studies ; Sirolimus/administration & dosage ; Sirolimus/adverse effects ; TOR Serine-Threonine Kinases/immunology ; Tacrolimus/administration & dosage ; Tacrolimus/adverse effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Berberine Attenuates Cardiac Hypertrophy Through Inhibition of mTOR Signaling Pathway.
Autorzy :
Chen X; Department of Geriatrics, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.; Guangzhou Institute of Cardiovascular Disease, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Jiang X; Department of Geriatrics, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Cheng C; Guangzhou Institute of Cardiovascular Disease, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Chen J; Guangzhou Institute of Cardiovascular Disease, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Huang S; Department of Geriatrics, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Xu M; Department of Geriatrics, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China. .
Liu S; Guangzhou Institute of Cardiovascular Disease, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China. .
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Źródło :
Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2020 Aug; Vol. 34 (4), pp. 463-473.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Berberine/*pharmacology
Hypertrophy, Left Ventricular/*prevention & control
Myocytes, Cardiac/*drug effects
Protein Kinase Inhibitors/*pharmacology
TOR Serine-Threonine Kinases/*antagonists & inhibitors
Ventricular Function, Left/*drug effects
Ventricular Remodeling/*drug effects
Animals ; Atrial Natriuretic Factor/metabolism ; Cell Line ; Disease Models, Animal ; Fibrosis ; Hypertrophy, Left Ventricular/enzymology ; Hypertrophy, Left Ventricular/pathology ; Hypertrophy, Left Ventricular/physiopathology ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Myocytes, Cardiac/enzymology ; Myocytes, Cardiac/pathology ; Natriuretic Peptide, Brain/metabolism ; Phosphorylation ; Rats, Sprague-Dawley ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways.
Autorzy :
Zervantonakis IK; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15213; .; UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA 15232.; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.
Poskus MD; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15213.
Scott AL; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15213.
Selfors LM; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.
Lin JR; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115.
Dillon DA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
Pathania S; Center for Personalized Cancer Therapy, University of Massachusetts Boston, Boston, MA 02125.
Sorger PK; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115.
Mills GB; Knight Cancer Institute, Oregon Health and Sciences University, Portland, OR 97239.
Brugge JS; Department of Cell Biology, Harvard Medical School, Boston, MA 02115; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 14; Vol. 117 (28), pp. 16500-16508. Date of Electronic Publication: 2020 Jun 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antineoplastic Agents/*pharmacology
Breast Neoplasms/*metabolism
Fibroblasts/*drug effects
Protein Kinase Inhibitors/*pharmacology
Receptor, ErbB-2/*antagonists & inhibitors
TOR Serine-Threonine Kinases/*metabolism
Apoptosis/drug effects ; Breast Neoplasms/genetics ; Breast Neoplasms/physiopathology ; Cell Line, Tumor ; Female ; Fibroblasts/cytology ; Fibroblasts/enzymology ; Humans ; Lapatinib/pharmacology ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/genetics
Czasopismo naukowe
Tytuł :
Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation.
Autorzy :
Toda G; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Molecular Diabetic Medicine, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Soeda K; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Molecular Diabetic Medicine, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Okazaki Y; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Molecular Diabetic Medicine, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Kobayashi N; Department of Molecular Diabetic Medicine, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Masuda Y; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Arakawa N; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Molecular Diabetic Medicine, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Suwanai H; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Masamoto Y; Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Izumida Y; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kamei N; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Sasako T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Suzuki R; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kubota T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kubota N; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kurokawa M; Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Tobe K; First Department of Internal Medicine, Toyama University, Toyama, Japan.
Noda T; Department of Cell Biology, Cancer Institute, Japanese Foundation of Cancer Research, Tokyo, Japan.
Honda K; Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Accili D; Columbia University College of Physicians & Surgeons, Department of Medicine, New York, NY 10032, USA.
Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Metabolism and Nutrition, Mizonokuchi Hospital, Faculty of Medicine, Teikyo University, Kanagawa, Japan. Electronic address: .
Ueki K; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Molecular Diabetic Medicine, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Jul 02; Vol. 79 (1), pp. 43-53.e4. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipose Tissue/*drug effects
Hyperglycemia/*pathology
Insulin/*pharmacology
Lipopolysaccharides/*pharmacology
Macrophages/*drug effects
Proto-Oncogene Proteins c-akt/*physiology
TOR Serine-Threonine Kinases/*metabolism
Adipose Tissue/metabolism ; Animals ; Blood Glucose/analysis ; Gluconeogenesis/genetics ; Hyperglycemia/etiology ; Hyperglycemia/metabolism ; Hypoglycemic Agents/pharmacology ; Insulin Resistance ; Interleukin-10/physiology ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C3H ; Mice, Knockout ; Postprandial Period ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; Tuberous Sclerosis Complex 2 Protein/physiology
Czasopismo naukowe
Tytuł :
Synergistic Antitumor Effects of Combined Treatment with HSP90 Inhibitor and PI3K/mTOR Dual Inhibitor in Cisplatin-Resistant Human Bladder Cancer Cells.
Autorzy :
Kim HJ; Department of Urology, Myunggok Medical Research Institute, Konyang University College of Medicine, Daejeon, Korea.; Department of Medicine, Graduate School of Yonsei University College of Medicine, Seoul, Korea.
Gong MK; School of Dentistry, Pusan National University, Yangsan, Korea.; Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
Yoon CY; Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
Kang J; Department of Pharmacology, College of Medicine, Konyang University, Daejeon, Korea.
Yun M; Department of Medicine, Graduate School of Yonsei University College of Medicine, Seoul, Korea.; Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Korea.
Cho NH; Department of Medicine, Graduate School of Yonsei University College of Medicine, Seoul, Korea.; Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
Rha SY; Department of Medicine, Graduate School of Yonsei University College of Medicine, Seoul, Korea.; Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Choi YD; Department of Medicine, Graduate School of Yonsei University College of Medicine, Seoul, Korea.; Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea. .
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Źródło :
Yonsei medical journal [Yonsei Med J] 2020 Jul; Vol. 61 (7), pp. 587-596.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Antineoplastic Agents/*therapeutic use
Benzoquinones/*therapeutic use
Cisplatin/*therapeutic use
Lactams, Macrocyclic/*therapeutic use
Protein Kinase Inhibitors/*therapeutic use
TOR Serine-Threonine Kinases/*antagonists & inhibitors
Urinary Bladder Neoplasms/*drug therapy
Antineoplastic Combined Chemotherapy Protocols ; Apoptosis/drug effects ; Benzoquinones/pharmacology ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cisplatin/pharmacology ; DNA Damage/drug effects ; Humans ; Imidazoles ; Lactams, Macrocyclic/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoinositide-3 Kinase Inhibitors ; Protein Kinase Inhibitors/pharmacology ; Quinolines ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Statins activate the NLRP3 inflammasome and impair insulin signaling via p38 and mTOR.
Autorzy :
Henriksbo BD; Department of Biochemistry and Biomedical Sciences and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton Ontario, Canada.
Tamrakar AK; Biochemistry Division, Council of Scientific and Industrial Research-Central Drug Research Institute, Lucknow, India.
Phulka JS; Department of Biochemistry and Biomedical Sciences and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton Ontario, Canada.
Barra NG; Department of Biochemistry and Biomedical Sciences and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton Ontario, Canada.
Schertzer JD; Department of Biochemistry and Biomedical Sciences and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton Ontario, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
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Źródło :
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2020 Jul 01; Vol. 319 (1), pp. E110-E116. Date of Electronic Publication: 2020 May 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Insulin Resistance*
Atorvastatin/*pharmacology
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology
Inflammasomes/*drug effects
Insulin/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*drug effects
TOR Serine-Threonine Kinases/*drug effects
p38 Mitogen-Activated Protein Kinases/*drug effects
Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Animals ; Inflammasomes/metabolism ; Interleukin-1beta/genetics ; MAP Kinase Kinase 4/drug effects ; MAP Kinase Kinase 4/metabolism ; Mice ; Mice, Knockout ; Mitogen-Activated Protein Kinase 1/drug effects ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/drug effects ; Mitogen-Activated Protein Kinase 3/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; PTEN Phosphohydrolase/drug effects ; PTEN Phosphohydrolase/metabolism ; TOR Serine-Threonine Kinases/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
mTOR Signaling Combined with Cancer Stem Cell Markers as a Survival Predictor in Stage II Colorectal Cancer.
Autorzy :
Chang JY; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Kim JH; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Kang J; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.; Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Park Y; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Park SJ; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Cheon JH; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Kim WH; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Kim H; Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.; Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Park JJ; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.; Yonsei Cancer Prevention Center, Seoul, Korea. .
Kim TI; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.; Yonsei Cancer Prevention Center, Seoul, Korea.; Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea. .
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Źródło :
Yonsei medical journal [Yonsei Med J] 2020 Jul; Vol. 61 (7), pp. 572-578.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, CD/*metabolism
Biomarkers, Tumor/*analysis
Colorectal Neoplasms/*metabolism
Colorectal Neoplasms/*pathology
Neoplastic Stem Cells/*metabolism
Neoplastic Stem Cells/*pathology
TOR Serine-Threonine Kinases/*metabolism
Biomarkers, Tumor/metabolism ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/mortality ; Colonic Neoplasms/pathology ; Colorectal Neoplasms/mortality ; Disease-Free Survival ; Female ; Humans ; Hyaluronan Receptors ; Male ; Middle Aged ; Neoplasm Staging ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/transplantation ; Prognosis ; Signal Transduction ; TOR Serine-Threonine Kinases/analysis ; beta Catenin
Czasopismo naukowe
Tytuł :
Molecular Pathways Leading to Induction of Cell Death and Anti-Proliferative Properties by Tacrolimus and mTOR Inhibitors in Liver Cancer Cells.
Autorzy :
Navarro-Villarán E; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Instituto de Salud Carlos III, Madrid, Spain.
de la Cruz-Ojeda P; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.
Contreras L; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Department of Genetics, University of Seville, Seville, Spain.
González R; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Instituto de Salud Carlos III, Madrid, Spain.
Negrete M; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.
Rodríguez-Hernández MA; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Instituto de Salud Carlos III, Madrid, Spain.
Marín-Gómez LM; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of General Surgery, Hospital University 'Virgen del Rocío'/CSIC/ University of Seville/IBiS, Seville, Spain.
Álamo-Martínez JM; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of General Surgery, Hospital University 'Virgen del Rocío'/CSIC/ University of Seville/IBiS, Seville, Spain.
Calvo A; Department of General Surgery, Hospital University of Puerto Real, Puerto Real, Spain.
Gómez-Bravo MA; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of General Surgery, Hospital University 'Virgen del Rocío'/CSIC/ University of Seville/IBiS, Seville, Spain.
de la Cruz J; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Department of Genetics, University of Seville, Seville, Spain.
Padillo J; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain.; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of General Surgery, Hospital University 'Virgen del Rocío'/CSIC/ University of Seville/IBiS, Seville, Spain.
Muntané J; Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen del Rocío'/CSIC/University of Seville, Seville, Spain, .; Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of General Surgery, Hospital University 'Virgen del Rocío'/CSIC/ University of Seville/IBiS, Seville, Spain.
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Źródło :
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2020 May 06; Vol. 54 (3), pp. 457-473.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Carcinoma, Hepatocellular/*metabolism
Immunosuppressive Agents/*pharmacology
Liver Neoplasms/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Tacrolimus/*pharmacology
Tacrolimus Binding Proteins/*metabolism
Autophagy/drug effects ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation/drug effects ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Endoplasmic Reticulum Stress/drug effects ; Everolimus/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Hep G2 Cells ; Hepatocytes/drug effects ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Small Interfering ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/genetics ; Tacrolimus Binding Protein 1A/metabolism ; Tumor Suppressor Protein p53/metabolism ; eIF-2 Kinase/metabolism
Czasopismo naukowe
Tytuł :
Integrative multiplatform molecular profiling of benign prostatic hyperplasia identifies distinct subtypes.
Autorzy :
Liu D; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Urology, Weill Cornell Medicine, New York, NY, USA.; HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA.; Englander Institute for Precision Medicine of Weill Cornell Medicine and NewYork-Presbyterian Hospital, New York, NY, USA.
Shoag JE; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Urology, Weill Cornell Medicine, New York, NY, USA.
Poliak D; Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Goueli RS; Department of Urology, Weill Cornell Medicine, New York, NY, USA.
Ravikumar V; Department of Urology, Weill Cornell Medicine, New York, NY, USA.
Redmond D; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Vosoughi A; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.
Fontugne J; Englander Institute for Precision Medicine of Weill Cornell Medicine and NewYork-Presbyterian Hospital, New York, NY, USA.; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.
Pan H; Englander Institute for Precision Medicine of Weill Cornell Medicine and NewYork-Presbyterian Hospital, New York, NY, USA.
Lee D; Department of Urology, Weill Cornell Medicine, New York, NY, USA.
Thomas D; Department of Urology, Weill Cornell Medicine, New York, NY, USA.
Salari K; Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Wang Z; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Romanel A; Department of Cellular, Computational and Integrative Biology (CIBIO), Trento, Italy.
Te A; Department of Urology, Weill Cornell Medicine, New York, NY, USA.
Lee R; Department of Urology, Weill Cornell Medicine, New York, NY, USA.
Chughtai B; Department of Urology, Weill Cornell Medicine, New York, NY, USA.
Olumi AF; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Mosquera JM; HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA.; Englander Institute for Precision Medicine of Weill Cornell Medicine and NewYork-Presbyterian Hospital, New York, NY, USA.; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.
Demichelis F; Department of Cellular, Computational and Integrative Biology (CIBIO), Trento, Italy.
Elemento O; HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA.; Englander Institute for Precision Medicine of Weill Cornell Medicine and NewYork-Presbyterian Hospital, New York, NY, USA.
Rubin MA; Englander Institute for Precision Medicine of Weill Cornell Medicine and NewYork-Presbyterian Hospital, New York, NY, USA.; Department of BioMedical Research, University of Bern and Inselspital, Bern, Switzerland.
Sboner A; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. .; HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA. .; Englander Institute for Precision Medicine of Weill Cornell Medicine and NewYork-Presbyterian Hospital, New York, NY, USA. .; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA. .
Barbieri CE; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. .; Department of Urology, Weill Cornell Medicine, New York, NY, USA. .; Englander Institute for Precision Medicine of Weill Cornell Medicine and NewYork-Presbyterian Hospital, New York, NY, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Apr 24; Vol. 11 (1), pp. 1987. Date of Electronic Publication: 2020 Apr 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Prostate/*pathology
Prostatic Hyperplasia/*genetics
TOR Serine-Threonine Kinases/*antagonists & inhibitors
Urological Agents/*therapeutic use
Adult ; Aged ; Aged, 80 and over ; Aging ; Biomarkers/analysis ; DNA Methylation ; Epigenesis, Genetic ; Epigenomics ; Genomics ; Humans ; Male ; Middle Aged ; Mutation Rate ; Organ Size/drug effects ; Organ Size/genetics ; Precision Medicine/methods ; Prospective Studies ; Prostate/diagnostic imaging ; Prostate/drug effects ; Prostatic Hyperplasia/diagnostic imaging ; Prostatic Hyperplasia/drug therapy ; Prostatic Hyperplasia/pathology ; RNA-Seq ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Sirolimus/analogs & derivatives ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Tomography, X-Ray Computed ; Treatment Outcome ; Urological Agents/pharmacology ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
Enhanced autocrine FGF19/FGFR4 signaling drives the progression of lung squamous cell carcinoma, which responds to mTOR inhibitor AZD2104.
Autorzy :
Li F; State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Li Z; Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Han Q; State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Cheng Y; State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Ji W; Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Yang Y; Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Lu S; Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Xia W; State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. .
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Źródło :
Oncogene [Oncogene] 2020 Apr; Vol. 39 (17), pp. 3507-3521. Date of Electronic Publication: 2020 Feb 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Squamous Cell*/drug therapy
Carcinoma, Squamous Cell*/metabolism
Carcinoma, Squamous Cell*/pathology
Lung Neoplasms*/drug therapy
Lung Neoplasms*/metabolism
Lung Neoplasms*/pathology
Neoplasm Proteins*/antagonists & inhibitors
Neoplasm Proteins*/metabolism
TOR Serine-Threonine Kinases*/antagonists & inhibitors
TOR Serine-Threonine Kinases*/metabolism
Autocrine Communication/*drug effects
Fibroblast Growth Factors/*metabolism
Protein Kinase Inhibitors/*pharmacology
Receptor, Fibroblast Growth Factor, Type 4/*metabolism
Signal Transduction/*drug effects
Animals ; Cell Line, Tumor ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude
Czasopismo naukowe
Tytuł :
MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer.
Autorzy :
Cipponi A; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia. .; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.
Goode DL; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia.
Bedo J; Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Computing and Information Systems, the University of Melbourne, Parkville, VIC, Australia.; Peter MacCallum Cancer Centre, Parkville, VIC, Australia.
McCabe MJ; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.; Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
Pajic M; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.
Croucher DR; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.
Rajal AG; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
Junankar SR; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.
Saunders DN; School of Medical Sciences, University of New South Wales, NSW, Australia.
Lobachevsky P; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Papenfuss AT; Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Computing and Information Systems, the University of Melbourne, Parkville, VIC, Australia.; Peter MacCallum Cancer Centre, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.
Nessem D; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
Nobis M; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.
Warren SC; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.
Timpson P; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.
Cowley M; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.; Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
Vargas AC; Douglass Hanly Moir Pathology, Turramurra, NSW, Australia.
Qiu MR; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.; Anatomical and Molecular Oncology Pathology, SYDPATH, St. Vincent's Hospital, Darlinghurst, NSW, Australia.
Generali DG; Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste, Italy.; Breast Cancer Unit and Translational Research Unit, ASST Cremona, Cremona, Italy.
Keerthikumar S; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia.
Nguyen U; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
Corcoran NM; Division of Urology, Royal Melbourne Hospital, Parkville, VIC, Australia.; Department of Urology, Peninsula Health, Frankston, VIC, Australia.; Department of Surgery, University of Melbourne, VIC, Australia.
Long GV; Melanoma Institute Australia, Wollstonecraft, NSW, Australia.; The University of Sydney, Sydney, NSW, Australia.; Royal North Shore Hospital and Mater Hospital, Sydney, NSW, Australia.; Crown Princess Mary Cancer Centre Westmead Hospital, Sydney, NSW, Australia.
Blay JY; Centre Leon Berard and Université Claude Bernard Lyon, Lyon, France.; UNICANCER, Paris, France.
Thomas DM; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia. .; St. Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.
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Źródło :
Science (New York, N.Y.) [Science] 2020 Jun 05; Vol. 368 (6495), pp. 1127-1131.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutagenesis*
Adaptation, Physiological/*genetics
Antineoplastic Agents/*pharmacology
Drug Resistance, Neoplasm/*genetics
Neoplasms/*drug therapy
Neoplasms/*genetics
TOR Serine-Threonine Kinases/*metabolism
Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; DNA Repair/genetics ; Genetic Fitness ; Genome-Wide Association Study ; Humans ; Selection, Genetic ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics
Czasopismo naukowe

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