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Wyszukujesz frazę ""TOR Serine-Threonine Kinases"" wg kryterium: Temat

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Wyświetlanie 1-20 z 4994
Tytuł:
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.
Autorzy:
Choi J; Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301, USA.
Chen J
Schreiber SL
Clardy J
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Źródło:
Science (New York, N.Y.) [Science] 1996 Jul 12; Vol. 273 (5272), pp. 239-42.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Immunophilins*
Phosphotransferases (Alcohol Group Acceptor)*
Protein Conformation*
Carrier Proteins/*metabolism
DNA-Binding Proteins/*metabolism
Heat-Shock Proteins/*metabolism
Polyenes/*chemistry
Polyenes/*metabolism
Binding Sites ; Carrier Proteins/chemistry ; Carrier Proteins/genetics ; Crystallography, X-Ray ; DNA-Binding Proteins/chemistry ; Heat-Shock Proteins/chemistry ; Humans ; Models, Molecular ; Mutation ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Sirolimus ; TOR Serine-Threonine Kinases ; Tacrolimus Binding Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway.
Autorzy:
West MJ; Department of Biochemistry, University of Leicester, UK.
Stoneley M
Willis AE
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Źródło:
Oncogene [Oncogene] 1998 Aug 13; Vol. 17 (6), pp. 769-80.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Immunophilins*
Phosphotransferases (Alcohol Group Acceptor)*
Protein Biosynthesis*
Proto-Oncogene Proteins c-myc/*biosynthesis
Adaptor Proteins, Signal Transducing ; Androstadienes/pharmacology ; B-Lymphocytes/metabolism ; Carrier Proteins/metabolism ; Cell Cycle Proteins ; Humans ; Phosphoproteins ; Phosphorylation ; Polyenes/pharmacology ; Proto-Oncogene Mas ; Ribosomal Protein S6 Kinases ; Signal Transduction ; Sirolimus ; TOR Serine-Threonine Kinases ; Wortmannin
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling.
Autorzy:
Sabatini DM; The Johns Hopkins University School of Medicine, Department of Neuroscience, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Barrow RK
Blackshaw S
Burnett PE
Lai MM
Field ME
Bahr BA
Kirsch J
Betz H
Snyder SH
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Źródło:
Science (New York, N.Y.) [Science] 1999 May 14; Vol. 284 (5417), pp. 1161-4.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Phosphotransferases (Alcohol Group Acceptor)*
Signal Transduction*
Carrier Proteins/*metabolism
Membrane Proteins/*metabolism
Phosphoproteins/*metabolism
Ribosomal Protein S6 Kinases/*metabolism
Sirolimus/*pharmacology
Adaptor Proteins, Signal Transducing ; Amino Acid Sequence ; Animals ; Carrier Proteins/chemistry ; Carrier Proteins/genetics ; Cell Cycle Proteins ; Cell Line ; Cell Membrane/metabolism ; Cytoplasm/metabolism ; Gene Expression ; HeLa Cells ; Humans ; Intracellular Signaling Peptides and Proteins ; Molecular Sequence Data ; Mutation ; Phosphorylation ; Rats ; Receptors, Glycine/metabolism ; Repressor Proteins/metabolism ; TOR Serine-Threonine Kinases
Czasopismo naukowe
Szczegóły
Tytuł:
DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling.
Autorzy:
Tee AR; Department of Anatomy & Physiology, Medical Sciences Institute/Wellcome Trust Building Complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.
Proud CG
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Źródło:
Oncogene [Oncogene] 2000 Jun 15; Vol. 19 (26), pp. 3021-31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Damage*
Protein Kinases*
Etoposide/*pharmacology
Mutagens/*pharmacology
Phosphotransferases (Alcohol Group Acceptor)/*metabolism
Protein Biosynthesis/*drug effects
Signal Transduction/*drug effects
3T3 Cells ; Amino Acid Sequence ; Animals ; Apoptosis/drug effects ; Cell Line ; Mice ; Molecular Sequence Data ; Protein Synthesis Inhibitors/pharmacology ; Rats ; TOR Serine-Threonine Kinases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro.
Autorzy:
Takahashi T; Biosignal Research Center, Kobe University, Kobe 657-8501, Japan.
Hara K
Inoue H
Kawa Y
Tokunaga C
Hidayat S
Yoshino K
Kuroda Y
Yonezawa K
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Źródło:
Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2000 Sep; Vol. 5 (9), pp. 765-75.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Kinases*
Phosphotransferases (Alcohol Group Acceptor)/*metabolism
Ribosomal Protein S6 Kinases/*metabolism
Amino Acid Sequence ; Cell Line ; Conserved Sequence ; Eukaryotic Initiation Factor-4E ; Humans ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Peptide Initiation Factors/metabolism ; Phosphorylation ; Phosphotransferases (Alcohol Group Acceptor)/chemistry ; Sequence Alignment ; Sequence Deletion ; Sirolimus/metabolism ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Transcription inhibitors stimulate translation of 5' TOP mRNAs through activation of S6 kinase and the mTOR/FRAP signalling pathway.
Autorzy:
Loreni F; Dipartimento di Biologia, Universita' 'Tor Vergata', Roma, Italy; Department of Growth Control, Friedrich Miescher Institut, Basel, Switzerland. />Thomas G
Amaldi F
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Źródło:
European journal of biochemistry [Eur J Biochem] 2000 Nov; Vol. 267 (22), pp. 6594-601.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Kinases*
Protein Serine-Threonine Kinases*
Xenopus Proteins*
Nucleic Acid Synthesis Inhibitors/*pharmacology
Protein Biosynthesis/*drug effects
RNA, Messenger/*genetics
Ribosomal Protein S6 Kinases/*metabolism
Transcription, Genetic/*drug effects
Amanitins/pharmacology ; Animals ; Ataxia Telangiectasia Mutated Proteins ; Cell Cycle Proteins/metabolism ; Cells, Cultured ; Dactinomycin/pharmacology ; Deoxyadenosines/pharmacology ; Dichlororibofuranosylbenzimidazole/pharmacology ; Enzyme Activation ; Kidney/cytology ; Kidney/drug effects ; Kidney/physiology ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology ; TOR Serine-Threonine Kinases ; Vertebrates ; Xenopus laevis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The rapamycin-sensitive signal transduction pathway as a target for cancer therapy.
Autorzy:
Hidalgo M; The University of Texas Health Science Center at San Antonio, Institute for Drug Development, Cancer Therapy and Research Center, 78229, USA.
Rowinsky EK
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Źródło:
Oncogene [Oncogene] 2000 Dec 27; Vol. 19 (56), pp. 6680-6.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Carrier Proteins*
Protein Kinases*
Antibiotics, Antineoplastic/*therapeutic use
Signal Transduction/*drug effects
Sirolimus/*therapeutic use
Adaptor Proteins, Signal Transducing ; Antibiotics, Antineoplastic/pharmacology ; Cell Cycle Proteins ; Clinical Trials, Phase I as Topic ; Humans ; Phosphoproteins/antagonists & inhibitors ; Protein Kinase Inhibitors ; Ribosomal Protein S6 Kinases/antagonists & inhibitors ; Sirolimus/analogs & derivatives ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases ; Tacrolimus Binding Protein 1A/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Staurosporine inhibits phosphorylation of translational regulators linked to mTOR.
Autorzy:
Tee AR; School of Life Sciences, Medical Sciences Institute/Wellcome Trust Building Complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK. />Proud CG
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Źródło:
Cell death and differentiation [Cell Death Differ] 2001 Aug; Vol. 8 (8), pp. 841-9.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*genetics
Enzyme Inhibitors/*pharmacology
Protein Biosynthesis/*physiology
Protein Kinases/*metabolism
RNA, Messenger/*metabolism
Staurosporine/*pharmacology
3T3 Cells ; Adaptor Proteins, Signal Transducing ; Animals ; Apoptosis/drug effects ; Carrier Proteins/drug effects ; Carrier Proteins/metabolism ; Caspases/drug effects ; Caspases/metabolism ; Cell Cycle Proteins ; Eukaryotic Initiation Factor-2/drug effects ; Eukaryotic Initiation Factor-2/metabolism ; Eukaryotic Initiation Factors ; Insulin/pharmacology ; Mice ; Phosphoproteins/drug effects ; Phosphoproteins/metabolism ; Phosphorylation/drug effects ; Protein Biosynthesis/drug effects ; Protein Kinase C/antagonists & inhibitors ; Protein Kinase C/metabolism ; Protein Kinases/drug effects ; Proteins/antagonists & inhibitors ; RNA, Messenger/drug effects ; Ribosomal Protein S6 Kinases/drug effects ; Ribosomal Protein S6 Kinases/metabolism ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.
Autorzy:
Rommel C; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591-6707, USA.
Bodine SC
Clarke BA
Rossman R
Nunez L
Stitt TN
Yancopoulos GD
Glass DJ
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Źródło:
Nature cell biology [Nat Cell Biol] 2001 Nov; Vol. 3 (11), pp. 1009-13.
Typ publikacji:
Journal Article
MeSH Terms:
Phosphoinositide-3 Kinase Inhibitors*
Protein Serine-Threonine Kinases*
Signal Transduction*
Calcium-Calmodulin-Dependent Protein Kinases/*metabolism
Insulin-Like Growth Factor I/*metabolism
Muscle, Skeletal/*metabolism
Muscular Atrophy/*metabolism
Protein Kinases/*metabolism
Proto-Oncogene Proteins/*metabolism
Adaptor Proteins, Signal Transducing ; Animals ; Calcineurin/metabolism ; Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors ; Carrier Proteins/metabolism ; Cell Cycle Proteins ; Cell Differentiation ; Cell Line ; Eukaryotic Initiation Factors ; Glycogen Synthase Kinase 3 ; Glycogen Synthase Kinases ; Insulin-Like Growth Factor I/pharmacology ; Mice ; Muscle, Skeletal/cytology ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoproteins/metabolism ; Phosphorylation ; Protein Kinase Inhibitors ; Proto-Oncogene Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt ; Ribosomal Protein S6 Kinases/metabolism ; TOR Serine-Threonine Kinases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo.
Autorzy:
Bodine SC; Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road, Tarrytown, New York 10591-6707, USA. />Stitt TN
Gonzalez M
Kline WO
Stover GL
Bauerlein R
Zlotchenko E
Scrimgeour A
Lawrence JC
Glass DJ
Yancopoulos GD
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Źródło:
Nature cell biology [Nat Cell Biol] 2001 Nov; Vol. 3 (11), pp. 1014-9.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Serine-Threonine Kinases*
Signal Transduction*
Muscle, Skeletal/*metabolism
Muscular Atrophy/*metabolism
Protein Kinases/*metabolism
Proto-Oncogene Proteins/*metabolism
Animals ; Calcineurin/metabolism ; Cardiomegaly/metabolism ; Cyclosporine/pharmacology ; Enzyme Inhibitors/pharmacology ; Female ; Proto-Oncogene Proteins c-akt ; Rats ; Rats, Sprague-Dawley ; Ribosomal Protein S6 Kinases/metabolism ; TOR Serine-Threonine Kinases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Phosphatidic acid-mediated mitogenic activation of mTOR signaling.
Autorzy:
Fang Y; Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, 601 South Goodwin Avenue, B107, Urbana, IL 61801, USA.
Vilella-Bach M
Bachmann R
Flanigan A
Chen J
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Źródło:
Science (New York, N.Y.) [Science] 2001 Nov 30; Vol. 294 (5548), pp. 1942-5.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Mitogens/*pharmacology
Phosphatidic Acids/*metabolism
Protein Kinases/*metabolism
Signal Transduction/*drug effects
Adaptor Proteins, Signal Transducing ; Butanols/pharmacology ; Carrier Proteins/metabolism ; Cell Cycle Proteins ; Cell Line ; Culture Media, Serum-Free ; Enzyme Activation/drug effects ; Humans ; Immunosuppressive Agents/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Phospholipase D/metabolism ; Phosphoproteins/metabolism ; Phosphorylation/drug effects ; Protein Binding ; Protein Kinases/chemistry ; Protein Structure, Tertiary ; Ribosomal Protein S6 Kinases/metabolism ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tumstatin, an endothelial cell-specific inhibitor of protein synthesis.
Autorzy:
Maeshima Y; Program in Matrix Biology, Department of Medicine and the Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Sudhakar A
Lively JC
Ueki K
Kharbanda S
Kahn CR
Sonenberg N
Hynes RO
Kalluri R
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Źródło:
Science (New York, N.Y.) [Science] 2002 Jan 04; Vol. 295 (5552), pp. 140-3.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Protein Biosynthesis*/drug effects
Protein Serine-Threonine Kinases*
Autoantigens/*pharmacology
Collagen Type IV/*pharmacology
Endothelium, Vascular/*cytology
Endothelium, Vascular/*metabolism
Protein Synthesis Inhibitors/*pharmacology
Adaptor Proteins, Signal Transducing ; Amino Acid Sequence ; Animals ; Autoantigens/chemistry ; Autoantigens/metabolism ; Carrier Proteins/metabolism ; Cattle ; Cell Cycle Proteins ; Cells, Cultured ; Collagen Type IV/chemistry ; Collagen Type IV/metabolism ; Endothelium, Vascular/drug effects ; Enzyme Activation/drug effects ; Eukaryotic Initiation Factor-4E ; Eukaryotic Initiation Factors ; Focal Adhesion Kinase 1 ; Focal Adhesion Protein-Tyrosine Kinases ; Humans ; Mice ; Molecular Sequence Data ; Peptide Fragments/pharmacology ; Peptide Initiation Factors/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoproteins/metabolism ; Phosphorylation ; Protein Kinase Inhibitors ; Protein Kinases/metabolism ; Protein-Tyrosine Kinases/metabolism ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-akt ; RNA Caps/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Vitronectin/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Beta-lactamase protein fragment complementation assays as in vivo and in vitro sensors of protein protein interactions.
Autorzy:
Galarneau A; Département de Biochimie, C.P. 6128, Succursale Centre-Ville, Montréal, QC, H3C 3J7, Canada.
Primeau M
Trudeau LE
Michnick SW
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Źródło:
Nature biotechnology [Nat Biotechnol] 2002 Jun; Vol. 20 (6), pp. 619-22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms:
Phosphotransferases (Alcohol Group Acceptor)*
Peptide Fragments/*chemistry
Protein Interaction Mapping/*methods
Proteins/*metabolism
beta-Lactamases/*genetics
beta-Lactamases/*metabolism
3-Phosphoinositide-Dependent Protein Kinases ; Animals ; Carrier Proteins/metabolism ; Cattle ; Cell Line ; Cephalosporins/metabolism ; DNA-Binding Proteins/metabolism ; Humans ; Immunophilins/metabolism ; Kidney/cytology ; Kidney/metabolism ; Leucine/metabolism ; Microscopy, Fluorescence/methods ; Peptide Library ; Protein Conformation ; Protein Folding ; Protein Interaction Mapping/instrumentation ; Protein Kinases/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Reproducibility of Results ; Saccharomyces cerevisiae Proteins/metabolism ; Sensitivity and Specificity ; Smad3 Protein ; TOR Serine-Threonine Kinases ; Trans-Activators/metabolism ; bcl-Associated Death Protein
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 4994

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