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Wyszukujesz frazę ""TOR Serine-Threonine Kinases - antagonists & inhibitors"" wg kryterium: Temat

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    Wyświetlanie 1-9 z 9
    Podgląd okładki
    Tytuł :
    Resistance to mTORC1 Inhibitors in Cancer Therapy: From Kinase Mutations to Intratumoral Heterogeneity of Kinase Activity.
    Index Terms :
    Animals; Drug Resistance, Neoplasm/drug effects; Drug Resistance, Neoplasm/genetics; Humans; Multiprotein Complexes/antagonists & inhibitors; Multiprotein Complexes/genetics; Mutation/genetics; Neoplasms/drug therapy; Neoplasms/enzymology; Neoplasms/genetics; Protein Kinase Inhibitors/pharmacology; Protein Kinase Inhibitors/therapeutic use; Signal Transduction/drug effects; TOR Serine-Threonine Kinases/antagonists & inhibitors; TOR Serine-Threonine Kinases/genetics
    info:eu-repo/semantics/review
    article
    URL :
    http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_71959E046B2F7
    Zasób elektroniczny
    Szczegóły
    Podgląd okładki
    Tytuł :
    Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors.
    Index Terms :
    Acids/adverse effects; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Colorectal Neoplasms/drug therapy; Colorectal Neoplasms/metabolism; Drug Therapy, Combination; Gene Expression Regulation, Neoplastic/drug effects; HT29 Cells; Humans; Mice; Multiprotein Complexes/antagonists & inhibitors; Multiprotein Complexes/metabolism; Sirolimus/administration & dosage; Sirolimus/pharmacology; Sodium Bicarbonate/administration & dosage; Sodium Bicarbonate/pharmacology; TOR Serine-Threonine Kinases/antagonists & inhibitors; TOR Serine-Threonine Kinases/metabolism; Tumor Microenvironment; Xenograft Model Antitumor Assays; Acidity; Rapamycin; Resistance Mechanisms; Sodium Bicarbonate; mTORC1
    info:eu-repo/semantics/article
    article
    URL :
    http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_1EC7442E4D3B9
    Zasób elektroniczny
    Szczegóły
    Podgląd okładki
    Tytuł :
    Effect of everolimus on bone marker levels and progressive disease in bone in BOLERO-2
    Index Terms :
    Cancérologie
    Aged
    Alkaline Phosphatase -- blood
    Androstadienes -- administration & dosage
    Antineoplastic Agents -- pharmacology -- therapeutic use
    Aromatase Inhibitors -- administration & dosage
    Bone Density -- drug effects
    Bone Density Conservation Agents -- pharmacology -- therapeutic use
    Bone Neoplasms -- blood -- metabolism -- prevention & control -- secondary
    Bone Remodeling -- drug effects
    Bone Resorption -- drug therapy -- prevention & control
    Breast Neoplasms -- blood -- chemistry -- pathology
    Collagen Type I -- metabolism
    Confounding Factors (Epidemiology)
    Disease Progression
    Disease-Free Survival
    Drug Administration Schedule
    Female
    Follow-Up Studies
    Fractures, Spontaneous -- etiology -- prevention & control
    Humans
    Middle Aged
    Odds Ratio
    Osteogenesis -- drug effects
    Postmenopause
    Procollagen -- blood
    Proportional Hazards Models
    Receptors, Estrogen -- analysis
    Sirolimus -- analogs & derivatives -- pharmacology -- therapeutic use
    TOR Serine-Threonine Kinases -- antagonists & inhibitors
    Treatment Failure
    Treatment Outcome
    info:eu-repo/semantics/article
    info:ulb-repo/semantics/articlePeerReview
    info:ulb-repo/semantics/openurl/article
    URL :
    http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/195353
    http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
    Zasób elektroniczny
    Szczegóły
    Podgląd okładki
    Tytuł :
    Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells.
    Index Terms :
    Animals; Antibiotics, Antineoplastic/pharmacology; Blotting, Western; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Colonic Neoplasms/drug therapy; Colonic Neoplasms/pathology; Female; Humans; Imidazoles/pharmacology; Immunohistochemistry; Indoles/pharmacology; Male; Mice; Protein Kinase Inhibitors/pharmacology; Purines/pharmacology; Quinolines/pharmacology; Sirolimus/pharmacology; TOR Serine-Threonine Kinases/antagonists & inhibitors; Xenograft Model Antitumor Assays
    info:eu-repo/semantics/article
    article
    URL :
    http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_6C2D069968980
    Zasób elektroniczny
    Szczegóły
    Podgląd okładki
    Tytuł :
    Phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway inhibition: a breakthrough in the management of luminal (ER+/HER2-) breast cancers?
    Index Terms :
    Sciences biomédicales
    Cancérologie
    Antineoplastic Agents -- pharmacology -- therapeutic use
    Breast Neoplasms -- drug therapy -- genetics -- metabolism
    Clinical Trials as Topic
    Drug Resistance, Neoplasm
    Female
    Humans
    Phosphatidylinositol 3-Kinases -- antagonists & inhibitors -- genetics -- metabolism
    Protein Kinase Inhibitors -- pharmacology -- therapeutic use
    Receptor, erbB-2 -- metabolism
    Receptors, Estrogen -- metabolism
    Signal Transduction -- drug effects
    Sirolimus -- pharmacology -- therapeutic use
    TOR Serine-Threonine Kinases -- antagonists & inhibitors -- metabolism
    info:eu-repo/semantics/article
    info:ulb-repo/semantics/articlePeerReview
    info:ulb-repo/semantics/openurl/article
    URL :
    http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/148656
    http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
    Zasób elektroniczny
    Szczegóły
    Podgląd okładki
    Tytuł :
    Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer.
    Index Terms :
    Cancérologie
    Adult
    Aged
    Aged, 80 and over
    Androstadienes -- adverse effects -- therapeutic use
    Antineoplastic Combined Chemotherapy Protocols -- adverse effects -- therapeutic use
    Aromatase Inhibitors -- adverse effects -- therapeutic use
    Bone Neoplasms -- secondary
    Breast Neoplasms -- chemistry -- drug therapy
    Disease-Free Survival
    Female
    Humans
    Kaplan-Meier Estimate
    Middle Aged
    Postmenopause
    Receptor, Epidermal Growth Factor -- analysis
    Recurrence
    Sirolimus -- adverse effects -- analogs & derivatives -- therapeutic use
    Stomatitis -- chemically induced
    TOR Serine-Threonine Kinases -- antagonists & inhibitors
    info:eu-repo/semantics/article
    info:ulb-repo/semantics/articlePeerReview
    info:ulb-repo/semantics/openurl/article
    URL :
    http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/144700
    http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
    Zasób elektroniczny
    Szczegóły
    Podgląd okładki
    Tytuł :
    Conversion of long-term kidney transplant recipients from calcineurin inhibitor therapy to everolimus a randomized, multicenter, 24-month study
    Index Terms :
    Adult
    Calcineurin - antagonists & inhibitors
    Sirolimus - administration & dosage, adverse effects, analogs & derivatives
    TOR Serine-Threonine Kinases - antagonists & inhibitors
    Time Factors
    Treatment Outcome
    Creatinine - blood, urine
    Female
    Glomerular Filtration Rate - drug effects
    Humans
    Immunosuppressive Agents - administration & dosage, adverse effects
    Kidney Transplantation - immunology, physiology
    Male
    Middle Aged
    info:eu-repo/semantics/article
    URL :
    http://hdl.handle.net/2078.1/113284
    Zasób elektroniczny
    Szczegóły
    Podgląd okładki
    Tytuł :
    Conversion of long-term kidney transplant recipients from calcineurin inhibitor therapy to everolimus a randomized, multicenter, 24-month study
    Index Terms :
    Adult
    Calcineurin - antagonists & inhibitors
    Sirolimus - administration & dosage, adverse effects, analogs & derivatives
    TOR Serine-Threonine Kinases - antagonists & inhibitors
    Time Factors
    Treatment Outcome
    Creatinine - blood, urine
    Female
    Glomerular Filtration Rate - drug effects
    Humans
    Immunosuppressive Agents - administration & dosage, adverse effects
    Kidney Transplantation - immunology, physiology
    Male
    Middle Aged
    info:eu-repo/semantics/article
    URL :
    http://hdl.handle.net/2078.1/113284
    Zasób elektroniczny
    Szczegóły
    Podgląd okładki
    Tytuł :
    Molecular targeted therapy in prevalent tumors: learning from the past and future perspectives.
    Index Terms :
    Cancérologie
    Antineoplastic Agents -- administration & dosage -- therapeutic use
    Drug Delivery Systems
    Drug Resistance, Neoplasm
    Forecasting
    Humans
    Individualized Medicine -- trends
    Molecular Targeted Therapy -- trends
    Neoplasms -- drug therapy
    Receptor, Epidermal Growth Factor -- antagonists & inhibitors -- metabolism
    TOR Serine-Threonine Kinases -- antagonists & inhibitors -- metabolism
    Breast cancer
    Colorectal cancer
    Lung cancer
    Resistance
    Targeted therapy
    Therapy individualization
    info:eu-repo/semantics/article
    info:ulb-repo/semantics/articlePeerReview
    info:ulb-repo/semantics/openurl/article
    URL :
    http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/118124
    http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
    Zasób elektroniczny
    Szczegóły
      Wyświetlanie 1-9 z 9

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