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Tytuł :
Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma.
Autorzy :
Pomella S; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
Sreenivas P; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Gryder BE; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
Wang L; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Milewski D; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
Cassandri M; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Baxi K; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Hensch NR; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Carcarino E; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Song Y; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
Chou HC; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
Yohe ME; Genetics Branch, NCI, NIH, Bethesda, MD, USA.; Pediatric Oncology Branch, NCI, NIH, Bethesda, MD, USA.
Stanton BZ; Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, 43205, USA.
Amadio B; SAFU Laboratory, Translational Research Area, Regina Elena National Cancer Institute, Rome, Italy.
Caruana I; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
De Stefanis C; Histology-Core Facility, Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy.
De Vito R; Department of Pathology Unit, Department of Laboratories, Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy.
Locatelli F; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Departmentof Pediatrics, Sapienza University of Rome, Rome, Italy.
Chen Y; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Chen EY; Department of Pathology, University of Washington, Seattle, WA, 98195, USA.
Houghton P; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Khan J; Genetics Branch, NCI, NIH, Bethesda, MD, USA. .
Rota R; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. .
Ignatius MS; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 08; Vol. 12 (1), pp. 192. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Differentiation*/genetics
Carcinogenesis/*metabolism
MyoD Protein/*metabolism
Oncogene Proteins, Fusion/*metabolism
Rhabdomyosarcoma/*genetics
Rhabdomyosarcoma/*metabolism
Snail Family Transcription Factors/*metabolism
Animals ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Heterografts ; Humans ; MEF2 Transcription Factors/metabolism ; Male ; Mice ; Mice, SCID ; Muscle Development/genetics ; MyoD Protein/genetics ; Myogenin/metabolism ; Oncogene Proteins, Fusion/genetics ; Oncogenes ; Rhabdomyosarcoma/pathology ; Rhabdomyosarcoma, Alveolar/genetics ; Rhabdomyosarcoma, Embryonal/genetics ; Snail Family Transcription Factors/genetics ; Transcriptome
Czasopismo naukowe
Tytuł :
Diosmin restores the skin barrier by targeting the aryl hydrocarbon receptor in atopic dermatitis.
Autorzy :
Lee J; Division of Functional Food Research, Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, South Korea.
Song KM; Division of Strategic Food Technology Research, Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, South Korea.
Jung CH; Division of Functional Food Research, Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, South Korea; Department of Food Biotechnology, Korea University of Science and Technology, Daejeon 34113, South Korea. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Jan; Vol. 81, pp. 153418. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Dermatitis, Atopic/*drug therapy
Dermatologic Agents/*pharmacology
Diosmin/*pharmacology
Receptors, Aryl Hydrocarbon/*metabolism
Skin/*drug effects
Basic Helix-Loop-Helix Transcription Factors/agonists ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cell Line ; Cytochrome P-450 CYP1A1/genetics ; Cytochrome P-450 CYP1A1/metabolism ; DNA-Binding Proteins/metabolism ; Dermatitis, Atopic/pathology ; Drug Evaluation, Preclinical/methods ; Gene Expression Regulation/drug effects ; Humans ; Intermediate Filament Proteins/genetics ; Intermediate Filament Proteins/metabolism ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Keratinocytes/pathology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Phytochemicals/pharmacology ; Receptors, Aryl Hydrocarbon/agonists ; Receptors, Aryl Hydrocarbon/genetics ; Skin/metabolism ; Skin/pathology ; Th2 Cells/metabolism ; Transcription Factors/metabolism ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Cigarette smoke modulates binding of the transcription factor MZF1 to the VEGF promoter and regulates VEGF expression in dependence of genetic variation SNP 405.
Autorzy :
Krüger M; Department of Oral and Maxillofacial Surgery - Plastic Surgery, University Medical Centre Mainz, Mainz, Germany.
Metzger C; Department of Otorhinolaryngology, University Medical Centre Mainz, Mainz, Germany.
Al-Nawas B; Department of Oral and Maxillofacial Surgery - Plastic Surgery, University Medical Centre Mainz, Mainz, Germany.
Kämmerer PW; Department of Oral and Maxillofacial Surgery - Plastic Surgery, University Medical Centre Mainz, Mainz, Germany.
Brieger J; Department of Otorhinolaryngology, University Medical Centre Mainz, Mainz, Germany.
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Źródło :
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2020 Sep; Vol. 49 (8), pp. 780-786. Date of Electronic Publication: 2020 Jun 16.
Typ publikacji :
Journal Article
MeSH Terms :
Transcription Factors*/genetics
Vascular Endothelial Growth Factor A*/genetics
Cell Line, Tumor ; Humans ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; Polymorphism, Single Nucleotide/genetics ; Smoking ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
The forkhead transcription factor FOXK2 premarks lineage-specific genes in human embryonic stem cells for activation during differentiation.
Autorzy :
Ji Z; Faculty of Biology, Medicine and Health, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.
Li Y; Faculty of Biology, Medicine and Health, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.
Liu SX; Faculty of Biology, Medicine and Health, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.
Sharrocks AD; Faculty of Biology, Medicine and Health, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Feb 22; Vol. 49 (3), pp. 1345-1363.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptional Activation*
Cell Differentiation/*genetics
Embryonic Stem Cells/*metabolism
Forkhead Transcription Factors/*metabolism
Cell Lineage/genetics ; Cells, Cultured ; Chromatin/metabolism ; Embryonic Stem Cells/cytology ; Endoderm/cytology ; Enhancer Elements, Genetic ; Histone Code ; Humans ; Mesoderm/cytology ; Neural Stem Cells/metabolism ; Neurogenesis/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Transcriptional regulation of human T-box 5 gene (TBX5) by bone- and cardiac-related transcription factors.
Autorzy :
Varela D; Centre of Marine Sciences (CCMAR), University of Algarve, Faro, Portugal; PhD Program in Biomedical Sciences, Faculty of Medicine and Biomedical Sciences, University of Algarve, Faro, Portugal.
Conceição N; Centre of Marine Sciences (CCMAR), University of Algarve, Faro, Portugal; Faculty of Medicine and Biomedical Sciences, University of Algarve, Faro, Portugal; Algarve Biomedical Centre (ABC) University of Algarve, Faro, Portugal. Electronic address: .
Cancela ML; Centre of Marine Sciences (CCMAR), University of Algarve, Faro, Portugal; Faculty of Medicine and Biomedical Sciences, University of Algarve, Faro, Portugal; Algarve Biomedical Centre (ABC) University of Algarve, Faro, Portugal; Centre for Biomedical Research (CBMR), University of Algarve, Faro, Portugal. Electronic address: .
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Źródło :
Gene [Gene] 2021 Feb 05; Vol. 768, pp. 145322. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
Cloning, Molecular/*methods
T-Box Domain Proteins/*genetics
T-Box Domain Proteins/*metabolism
Transcription Factors/*metabolism
Binding Sites ; Bone and Bones/metabolism ; Computer Simulation ; Early Growth Response Protein 1/metabolism ; Gene Expression Regulation ; HEK293 Cells ; Humans ; MEF2 Transcription Factors/metabolism ; Myocardium/metabolism ; Promoter Regions, Genetic ; SOX9 Transcription Factor/metabolism ; T-Box Domain Proteins/chemistry
Czasopismo naukowe
Tytuł :
The PITX gene family as potential biomarkers and therapeutic targets in lung adenocarcinoma.
Autorzy :
Zhang C; Department of Respiratory Medicine, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Zhejiang China.
Chen X
Chen Y
Cao M
Tang J
Zhong B
He M
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Jan 29; Vol. 100 (4), pp. e23936.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Adenocarcinoma of Lung/*pathology
Lung Neoplasms/*pathology
Paired Box Transcription Factors/*genetics
Biomarkers, Tumor ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins/genetics ; Humans ; Kaplan-Meier Estimate ; Prognosis ; RNA, Messenger ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
An eggplant SmICE1a gene encoding MYC-type ICE1-like transcription factor enhances freezing tolerance in transgenic Arabidopsis thaliana.
Autorzy :
Zhou L; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
He YJ; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Li J; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Li LZ; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Liu Y; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Chen HY; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
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Źródło :
Plant biology (Stuttgart, Germany) [Plant Biol (Stuttg)] 2020 May; Vol. 22 (3), pp. 450-458. Date of Electronic Publication: 2020 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Arabidopsis*/genetics
Freezing*
Plants, Genetically Modified*
Solanum melongena*/genetics
Transcription Factors*/genetics
Transcription Factors*/metabolism
Basic Helix-Loop-Helix Transcription Factors ; Gene Expression Regulation, Plant
Czasopismo naukowe
Tytuł :
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.
Autorzy :
Aras S; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201.
Purandare N; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201.
Gladyck S; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201.
Somayajulu-Nitu M; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201.
Zhang K; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201.
Wallace DC; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104; .; Department of Pediatrics, Division of Human Genetics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Grossman LI; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 15; Vol. 117 (50), pp. 32056-32065. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Nucleus/*metabolism
DNA, Mitochondrial/*genetics
DNA-Binding Proteins/*metabolism
MELAS Syndrome/*pathology
Mitochondria/*metabolism
Transcription Factors/*metabolism
Activating Transcription Factors/metabolism ; Autophagy/genetics ; Cell Fractionation ; Cell Respiration/genetics ; DNA-Binding Proteins/genetics ; Gene Knockout Techniques ; HEK293 Cells ; Humans ; MELAS Syndrome/genetics ; Mitochondria/genetics ; Mutation ; Oxygen/metabolism ; Transcription Factors/genetics ; Unfolded Protein Response/genetics
Czasopismo naukowe
Tytuł :
Distinct transcriptional programs of SOX2 in different types of small cell lung cancers.
Autorzy :
Tenjin Y; Department of Pathology and Experimental Medicine, Graduate School of Medical Science, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, 860-8556, Japan.; Department of Respiratory Medicine, Graduate School of Medical Science, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, 860-8556, Japan.
Matsuura K; Department of Pluripotent Stem Cell Biology, Kumamoto University, Honjo 2-2-1, Chuo-ku, Kumamoto, 860-0811, Japan.
Kudoh S; Department of Pathology and Experimental Medicine, Graduate School of Medical Science, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, 860-8556, Japan.
Usuki S; Liaison Laboratory Research Promotion Center (LILA), Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo 2-2-1, Chuo-ku, Kumamoto, 860-0811, Japan.
Yamada T; Department of Pathology and Experimental Medicine, Graduate School of Medical Science, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, 860-8556, Japan.; Department of Thoracic Surgery, Graduate School of Medical Science, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, 860-8556, Japan.
Matsuo A; Department of Pathology and Experimental Medicine, Graduate School of Medical Science, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, 860-8556, Japan.
Sato Y; Department of Pathology and Experimental Medicine, Graduate School of Medical Science, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, 860-8556, Japan.
Saito H; Department of Pathology and Experimental Medicine, Graduate School of Medical Science, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, 860-8556, Japan.; Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, 860-8556, Japan.
Fujino K; Department of Pathology and Experimental Medicine, Graduate School of Medical Science, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, 860-8556, Japan.; Department of Thoracic Surgery, Graduate School of Medical Science, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, 860-8556, Japan.
Wakimoto J; Division of Pathology, Minami Kyushu National Hospital, Kagoshima, 899-5293, Japan.
Ichimura T; Department of Pathology, Faculty of Medicine, Saitama Medical University, Saitama, 350-0495, Japan.
Kohrogi H; Department of Respiratory Medicine, Omuta Tenryo Hospital, Tenryo 1-100, Omuta, Fukuoka, 836-8556, Japan.
Sakagami T; Department of Respiratory Medicine, Graduate School of Medical Science, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, 860-8556, Japan.
Niwa H; Department of Pluripotent Stem Cell Biology, Kumamoto University, Honjo 2-2-1, Chuo-ku, Kumamoto, 860-0811, Japan.
Ito T; Department of Pathology and Experimental Medicine, Graduate School of Medical Science, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, 860-8556, Japan. .
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Źródło :
Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2020 Dec; Vol. 100 (12), pp. 1575-1588. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic/*genetics
Lung Neoplasms/*metabolism
SOXB1 Transcription Factors/*metabolism
Small Cell Lung Carcinoma/*metabolism
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Line, Tumor ; Humans ; Lung/chemistry ; Lung Neoplasms/chemistry ; Lung Neoplasms/classification ; Lung Neoplasms/genetics ; Male ; Mice ; Phenotype ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; SOXB1 Transcription Factors/genetics ; Small Cell Lung Carcinoma/chemistry ; Small Cell Lung Carcinoma/classification ; Small Cell Lung Carcinoma/genetics
Czasopismo naukowe
Tytuł :
ZFP423 regulates early patterning and multiciliogenesis in the hindbrain choroid plexus.
Autorzy :
Casoni F; Università Vita-Salute San Raffaele, Milan, Italy .; Division of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy.
Croci L; Division of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy.
Vincenti F; Università Vita-Salute San Raffaele, Milan, Italy.
Podini P; Division of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy.
Riba M; Center for Omics Sciences, IRCCS, San Raffaele Hospital, Milan 20132, Italy.
Massimino L; Division of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy.
Cremona O; Università Vita-Salute San Raffaele, Milan, Italy.; Division of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy.
Consalez GG; Università Vita-Salute San Raffaele, Milan, Italy.; Division of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy.
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Źródło :
Development (Cambridge, England) [Development] 2020 Nov 30; Vol. 147 (22). Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Choroid Plexus/*embryology
DNA-Binding Proteins/*metabolism
Rhombencephalon/*embryology
Transcription Factors/*metabolism
Animals ; Choroid Plexus/cytology ; DNA-Binding Proteins/genetics ; LIM-Homeodomain Proteins/genetics ; LIM-Homeodomain Proteins/metabolism ; Mice ; Mice, Mutant Strains ; Otx Transcription Factors/genetics ; Otx Transcription Factors/metabolism ; Rhombencephalon/cytology ; Transcription Factors/genetics ; Wnt3 Protein/genetics ; Wnt3 Protein/metabolism
Czasopismo naukowe
Tytuł :
Alignment and quantification of ChIP-exo crosslinking patterns reveal the spatial organization of protein-DNA complexes.
Autorzy :
Yamada N; Center for Eukaryotic Gene Regulation, Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Rossi MJ; Center for Eukaryotic Gene Regulation, Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Farrell N; Center for Eukaryotic Gene Regulation, Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Pugh BF; Center for Eukaryotic Gene Regulation, Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Mahony S; Center for Eukaryotic Gene Regulation, Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Nov 18; Vol. 48 (20), pp. 11215-11226.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Chromatin Immunoprecipitation/*methods
DNA-Binding Proteins/*metabolism
Exonucleases/*chemistry
RNA, Transfer/*genetics
Ribosomal Proteins/*genetics
Sequence Alignment/*methods
Transcription Factors/*metabolism
Algorithms ; Animals ; Binding Sites ; Computer Simulation ; DNA-Binding Proteins/chemistry ; Databases, Genetic ; Drosophila/chemistry ; Drosophila/genetics ; Drosophila/metabolism ; Promoter Regions, Genetic ; Protein Binding ; RNA Polymerase II/chemistry ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; RNA Polymerase III/chemistry ; RNA Polymerase III/genetics ; RNA Polymerase III/metabolism ; RNA, Transfer/chemistry ; RNA, Transfer/metabolism ; Ribosomal Proteins/chemistry ; Ribosomal Proteins/metabolism ; Saccharomyces cerevisiae/chemistry ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Sequence Analysis, DNA/methods ; Transcription Factor TFIIIB/chemistry ; Transcription Factor TFIIIB/genetics ; Transcription Factor TFIIIB/metabolism ; Transcription Factors/chemistry ; Transcription Factors/genetics ; Transcription Factors, TFIII/chemistry ; Transcription Factors, TFIII/genetics ; Transcription Factors, TFIII/metabolism ; Transcription Initiation Site
Czasopismo naukowe
Tytuł :
The Importance of Hypoxia-Inducible Factors (HIF-1 and HIF-2) for the Pathophysiology of Inflammatory Bowel Disease.
Autorzy :
Kerber EL; Institute for Physiology, University of Duisburg-Essen, 45147 Essen, Germany.
Padberg C; Institute for Physiology, University of Duisburg-Essen, 45147 Essen, Germany.
Koll N; Institute for Physiology, University of Duisburg-Essen, 45147 Essen, Germany.
Schuetzhold V; Institute for Physiology, University of Duisburg-Essen, 45147 Essen, Germany.
Fandrey J; Institute for Physiology, University of Duisburg-Essen, 45147 Essen, Germany.
Winning S; Institute for Physiology, University of Duisburg-Essen, 45147 Essen, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 13; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article
MeSH Terms :
Inflammatory Bowel Diseases*/chemically induced
Inflammatory Bowel Diseases*/genetics
Inflammatory Bowel Diseases*/immunology
Inflammatory Bowel Diseases*/physiopathology
Basic Helix-Loop-Helix Transcription Factors/*immunology
Hypoxia-Inducible Factor 1, alpha Subunit/*immunology
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; CD4 Antigens/genetics ; CD4 Antigens/immunology ; CD8 Antigens/genetics ; CD8 Antigens/immunology ; Dextran Sulfate/toxicity ; Disease Models, Animal ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/immunology ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; Interleukin-10/genetics ; Interleukin-10/immunology ; Interleukin-6/genetics ; Interleukin-6/immunology ; Mice ; Mice, Knockout ; Myeloid Cells/immunology ; Myeloid Cells/pathology
Czasopismo naukowe
Tytuł :
Kynurenine Promotes RANKL-Induced Osteoclastogenesis In Vitro by Activating the Aryl Hydrocarbon Receptor Pathway.
Autorzy :
Eisa NH; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29403, USA.; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29403, USA.; Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Reddy SV; Darby Children's Research Institute, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA.
Elmansi AM; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29403, USA.; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29403, USA.
Kondrikova G; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29403, USA.; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29403, USA.
Kondrikov D; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29403, USA.; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29403, USA.
Shi XM; Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.; Department of Orthopaedic Surgery, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Novince CM; Department of Oral Health Sciences, College of Dental Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.; Department of Stomatology, College of Dental Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Hamrick MW; Department of Orthopaedic Surgery, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.; Center for Healthy Aging, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.; Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
McGee-Lawrence ME; Department of Orthopaedic Surgery, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.; Center for Healthy Aging, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.; Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Isales CM; Department of Orthopaedic Surgery, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.; Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.; Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.; Division of Endocrinology, Diabetes and Metabolism, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Fulzele S; Department of Orthopaedic Surgery, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.; Center for Healthy Aging, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Hill WD; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29403, USA.; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29403, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 26; Vol. 21 (21). Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :
Journal Article
MeSH Terms :
Osteogenesis*
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Kynurenine/*pharmacology
RANK Ligand/*pharmacology
Receptors, Aryl Hydrocarbon/*metabolism
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Gene Expression Regulation/drug effects ; Mice ; NFATC Transcription Factors/genetics ; NFATC Transcription Factors/metabolism ; Proto-Oncogene Proteins c-fos/genetics ; Proto-Oncogene Proteins c-fos/metabolism ; RAW 264.7 Cells ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Glutamate/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
HIF-2α is indispensable for regulatory T cell function.
Autorzy :
Hsu TS; Institute of Molecular Biology, Academia Sinica, 11529, Taipei, Taiwan.
Lin YL; Institute of Molecular Biology, Academia Sinica, 11529, Taipei, Taiwan.
Wang YA; Institute of Molecular Biology, Academia Sinica, 11529, Taipei, Taiwan.
Mo ST; Institute of Molecular Biology, Academia Sinica, 11529, Taipei, Taiwan.
Chi PY; Institute of Biomedical Sciences, Academia Sinica, 11529, Taipei, Taiwan.
Lai AC; Institute of Biomedical Sciences, Academia Sinica, 11529, Taipei, Taiwan.
Pan HY; Institute of Molecular Biology, Academia Sinica, 11529, Taipei, Taiwan.
Chang YJ; Institute of Biomedical Sciences, Academia Sinica, 11529, Taipei, Taiwan.
Lai MZ; Institute of Molecular Biology, Academia Sinica, 11529, Taipei, Taiwan. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 06; Vol. 11 (1), pp. 5005. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*metabolism
T-Lymphocytes, Regulatory/*physiology
Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Bronchial Hyperreactivity/genetics ; CD4-Positive T-Lymphocytes/cytology ; Cell Differentiation ; Cellular Reprogramming ; Colitis/etiology ; Colitis/pathology ; Colonic Neoplasms/genetics ; Colonic Neoplasms/pathology ; Female ; Forkhead Transcription Factors/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Interleukin-17/metabolism ; Male ; Melanoma/genetics ; Melanoma/pathology ; Mice, Knockout ; T-Lymphocytes, Regulatory/metabolism
Czasopismo naukowe
Tytuł :
Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte.
Autorzy :
Trivedi PC; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada; Dalhousie Medicine New Brunswick, E2L 4L5 Saint John, NB, Canada.
Bartlett JJ; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada; Dalhousie Medicine New Brunswick, E2L 4L5 Saint John, NB, Canada.
Mercer A; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada; Dalhousie Medicine New Brunswick, E2L 4L5 Saint John, NB, Canada.
Slade L; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada; Dalhousie Medicine New Brunswick, E2L 4L5 Saint John, NB, Canada.
Surette M; Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada.
Ballabio A; Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Napoli, Italy.
Flibotte S; Department of Zoology, University of British Columbia, 4200 University Blvd, V6T 1Z4 Vancouver, BC, Canada.
Hussein B; Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, V6T 1Z3 Vancouver, BC, Canada.
Rodrigues B; Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, V6T 1Z3 Vancouver, BC, Canada.
Kienesberger PC; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada; Dalhousie Medicine New Brunswick, E2L 4L5 Saint John, NB, Canada.
Pulinilkunnil T; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada; Dalhousie Medicine New Brunswick, E2L 4L5 Saint John, NB, Canada. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2020 Oct 01; Vol. 1866 (10), pp. 165832. Date of Electronic Publication: 2020 May 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/*genetics
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/*metabolism
Cell Death/*physiology
Lipid Metabolism/*physiology
Myocytes, Cardiac/*metabolism
Animals ; Apoptosis/physiology ; Autophagy/drug effects ; Cell Nucleus ; Gene Expression Regulation ; Kruppel-Like Transcription Factors/metabolism ; Lysosomes/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Obesity/metabolism ; Signal Transduction/physiology ; Transcriptome
Czasopismo naukowe
Tytuł :
Targeting the SAGA and ATAC Transcriptional Coactivator Complexes in MYC-Driven Cancers.
Autorzy :
Mustachio LM; Departments of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Roszik J; Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Farria A; Departments of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Dent SYR; Departments of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas. .; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Źródło :
Cancer research [Cancer Res] 2020 May 15; Vol. 80 (10), pp. 1905-1911. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Embryonic Development*
Neoplasms*
Proto-Oncogene Proteins c-myc*
Transcription Factors*
Animals ; Humans ; p300-CBP Transcription Factors
Czasopismo naukowe
Tytuł :
The ABL2 kinase regulates an HSF1-dependent transcriptional program required for lung adenocarcinoma brain metastasis.
Autorzy :
Hoj JP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710.
Mayro B; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710.
Pendergast AM; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710 .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 29; Vol. 117 (52), pp. 33486-33495. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Adenocarcinoma of Lung/*genetics
Adenocarcinoma of Lung/*pathology
Brain Neoplasms/*secondary
Heat Shock Transcription Factors/*metabolism
Lung Neoplasms/*genetics
Lung Neoplasms/*pathology
Protein-Tyrosine Kinases/*metabolism
Allosteric Regulation ; Animals ; Cell Line, Tumor ; Cell Survival ; E2F Transcription Factors/metabolism ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Mice, Nude ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
Characteristics of banana B genome MADS-box family demonstrate their roles in fruit development, ripening, and stress.
Autorzy :
Zheng Y; College of Horticulture, Hainan University, Haikou, 571100, China.
Liu M; College of Horticulture, Hainan University, Haikou, 571100, China.
Jia C; Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, 4 Xueyuan Road, Haikou, 571101, China.
Wang J; Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, 4 Xueyuan Road, Haikou, 571101, China.
Xu B; Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, 4 Xueyuan Road, Haikou, 571101, China.
Jin Z; Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, 4 Xueyuan Road, Haikou, 571101, China.; Hainan Academy of Tropical Agricultural Resource, Chinese Academy of Tropical Agricultural Sciences, 4 Xueyuan Road, Haikou, 571101, China.
Li W; College of Horticulture, Hainan University, Haikou, 571100, China. .
Liu J; Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, 4 Xueyuan Road, Haikou, 571101, China. .; Hainan Academy of Tropical Agricultural Resource, Chinese Academy of Tropical Agricultural Sciences, 4 Xueyuan Road, Haikou, 571101, China. .
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 30; Vol. 10 (1), pp. 20840. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MADS Domain Proteins/*genetics
MEF2 Transcription Factors/*genetics
Musa/*genetics
Conserved Sequence/genetics ; Evolution, Molecular ; Fruit/genetics ; Gene Expression Profiling/methods ; Gene Expression Regulation, Plant/genetics ; Genome, Plant/genetics ; Multigene Family/genetics ; Musa/growth & development ; Phylogeny ; Plant Proteins/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
ZFAT binds to centromeres to control noncoding RNA transcription through the KAT2B-H4K8ac-BRD4 axis.
Autorzy :
Ishikura S; Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.; Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Nakabayashi K; Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.
Nagai M; Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Tsunoda T; Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.; Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Shirasawa S; Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.; Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Nov 04; Vol. 48 (19), pp. 10848-10866.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Centromere/*metabolism
RNA, Untranslated/*metabolism
Transcription Factors/*metabolism
Animals ; Cell Cycle Proteins/metabolism ; Cell Line ; Chromosome Segregation ; Gene Expression Regulation ; Histones/metabolism ; Humans ; Mice ; Protein Binding ; Transcription, Genetic ; p300-CBP Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screen.
Autorzy :
Liu J; Aging Institute of University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.; Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.
Zuo Z; Aging Institute of University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.
Zou M; Aging Institute of University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.
Finkel T; Aging Institute of University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.; Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.
Liu S; Aging Institute of University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.
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Źródło :
PLoS genetics [PLoS Genet] 2020 Oct 15; Vol. 16 (10), pp. e1009068. Date of Electronic Publication: 2020 Oct 15 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Elongation Factor 2 Kinase/*genetics
Histidine/*analogs & derivatives
Kruppel-Like Transcription Factors/*genetics
Minor Histocompatibility Antigens/*genetics
Tumor Suppressor Proteins/*genetics
Animals ; BTB-POZ Domain/genetics ; CRISPR-Cas Systems/genetics ; Gene Expression Regulation/genetics ; Histidine/biosynthesis ; Histidine/genetics ; Humans ; Methyltransferases ; Mice ; Promoter Regions, Genetic/genetics ; Protein Binding/genetics ; Protein Processing, Post-Translational/genetics ; RAW 264.7 Cells ; Transcription Factors/genetics
Czasopismo naukowe

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