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Tytuł :
Frequent fragility of randomized controlled trials for HCC treatment.
Autorzy :
Zhang H; Department of Infectious Diseases, The Key Discipline of Gguangdong Province, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, #151 Yanjiang Road, Guangzhou, 510120, Guangdong Province, China.
Li J; Department of liver diseases (I), The Hospital Affiliated to Shaanxi University of Chinese Medicine, Xianyang, 712000, Shaanxi Province, China. .
Zeng W; Department of Infectious Diseases, The Key Discipline of Gguangdong Province, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, #151 Yanjiang Road, Guangzhou, 510120, Guangdong Province, China. .
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Źródło :
BMC cancer [BMC Cancer] 2021 Apr 09; Vol. 21 (1), pp. 389. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Models, Statistical*
Randomized Controlled Trials as Topic*/methods
Randomized Controlled Trials as Topic*/standards
Carcinoma, Hepatocellular/*therapy
Liver Neoplasms/*therapy
Outcome Assessment, Health Care/*methods
Clinical Trials, Phase III as Topic ; Humans
Czasopismo naukowe
Tytuł :
Cancer Clinical Trials: What Every Radiologist Wants to Know but Is Afraid to Ask.
Autorzy :
Alessandrino F; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Smith DA; Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106.
Spierling A; Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106.
Kikano E; Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106.
Somarouthu B; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Tirumani SH; Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106.
Ramaiya NH; Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106.
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Źródło :
AJR. American journal of roentgenology [AJR Am J Roentgenol] 2021 Apr; Vol. 216 (4), pp. 1099-1111. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Clinical Trials as Topic*
Radiologists*
Neoplasms/*diagnostic imaging
Biomarkers, Tumor ; Drug Development ; Humans ; Neoplasms/therapy ; Randomized Controlled Trials as Topic ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Pride and Prejudice during the COVID-19 Pandemic: The Misfortune of Inappropriate Clinical Trial Design.
Autorzy :
Hashmi SK; Clinical Trials Unit, King Faisal Specialist Hospital & Research Centre, Riyadh, KSA.; Division of Hematology, Dept. of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
De Vol E; Dept. of Biostatistics & Epidemiology, King Faisal Specialist Hospital & Research Centre, Riyadh, KSA.
Hussain F; College of Medicine, Alfaisal University, Riyadh, KSA.
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Źródło :
Journal of epidemiology and global health [J Epidemiol Glob Health] 2021 Mar; Vol. 11 (1), pp. 15-19. Date of Electronic Publication: 2020 Aug 07.
Typ publikacji :
Journal Article
MeSH Terms :
Information Dissemination*/ethics
Information Dissemination*/methods
Non-Randomized Controlled Trials as Topic*/ethics
Non-Randomized Controlled Trials as Topic*/methods
Non-Randomized Controlled Trials as Topic*/standards
Research Design*/standards
Research Design*/trends
Safety Management*/ethics
Safety Management*/standards
COVID-19/*drug therapy
COVID-19/epidemiology ; Early Termination of Clinical Trials/methods ; Ethics ; Humans ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Insights from compassionate use of tocilizumab for COVID-19 to inform appropriate design of randomised controlled trials.
Autorzy :
Baker EH; Institute of Infection and Immunity, St George's, University of London, London, UK.; Pharmacy and Medicines Directorate, St George's University Hospitals NHS Foundation Trust, London, UK.
Patel K; Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, UK.
Ball J; Adult Critical Care Directorate, St George's University Hospitals NHS Foundation Trust, London, UK.
Edwards S; Department of Science and Technology Studies, University College London, London, UK.
Harrison TS; Institute of Infection and Immunity, St George's, University of London, London, UK.; Clinical Infection Unit, St George's University Hospitals NHS Foundation Trust, London, UK.
Kaul A; Department of Rheumatology, St George's University Hospitals NHS Foundation Trust, London, UK.
Koh M; Department of Haematology, St George's University Hospitals NHS Foundation Trust, London, UK.
Krishna S; Institute of Infection and Immunity, St George's, University of London, London, UK.; Clinical Infection Unit, St George's University Hospitals NHS Foundation Trust, London, UK.; Institut für Tropenmedizin, Universitätsklinikum Tübingen, Tübingen, Germany.; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon.
Leaver S; Adult Critical Care Directorate, St George's University Hospitals NHS Foundation Trust, London, UK.
Kumar V; Pharmacy and Medicines Directorate, St George's University Hospitals NHS Foundation Trust, London, UK.
Forton DM; Institute of Infection and Immunity, St George's, University of London, London, UK.; Department of Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, UK.
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Źródło :
British journal of clinical pharmacology [Br J Clin Pharmacol] 2021 Mar; Vol. 87 (3), pp. 1584-1586. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Letter
MeSH Terms :
Compassionate Use Trials*
Antibodies, Monoclonal, Humanized/*therapeutic use
COVID-19/*drug therapy
Antibodies, Monoclonal, Humanized/adverse effects ; COVID-19/complications ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/etiology ; Humans ; Randomized Controlled Trials as Topic ; Research Design ; Treatment Outcome
Opinia redakcyjna
Tytuł :
Rationale and design of the TAILOR-PCI digital study: Transitioning a randomized controlled trial to a digital registry.
Autorzy :
Pereira NL; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN. Electronic address: .
Avram R; University of California San Francisco, San Francisco, CA.
So DY; University of Ottawa Heart Institute, Ottawa, Canada.
Iturriaga E; National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD.
Byrne J; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.
Lennon RJ; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.
Murthy V; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.
Geller N; National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD.
Goodman SG; St. Michael's Hospital, University of Toronto, Toronto, and Canadian VIGOUR Centre, University of Alberta, Edmonton, Canada.
Rihal C; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.
Rosenberg Y; National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD.
Bailey K; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.
Pletcher MJ; University of California San Francisco, San Francisco, CA.
Marcus GM; University of California San Francisco, San Francisco, CA.
Farkouh ME; Peter Munk Cardiac Centre, Toronto, Canada.
Olgin JE; University of California San Francisco, San Francisco, CA. Electronic address: .
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Źródło :
American heart journal [Am Heart J] 2021 Feb; Vol. 232, pp. 84-93. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Internet-Based Intervention*
Multicenter Studies as Topic*
Patient Generated Health Data*
Randomized Controlled Trials as Topic*
Registries*
COVID-19/epidemiology ; Clopidogrel/therapeutic use ; Continuity of Patient Care ; Feasibility Studies ; Follow-Up Studies ; Genotype ; Geographic Information Systems ; Health Surveys/methods ; Humans ; Ischemia/drug therapy ; Mobile Applications ; Patient Compliance ; Patient Participation ; Percutaneous Coronary Intervention ; Postoperative Complications/drug therapy ; Pragmatic Clinical Trials as Topic ; Purinergic P2Y Receptor Antagonists/therapeutic use ; Research Design ; SARS-CoV-2 ; Telephone
Czasopismo naukowe
Tytuł :
Evaluation of the initial response in clinical trial efforts for COVID-19 in Brazil.
Autorzy :
Ribeiro TB; Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo - São Paulo (SP), Brasil.
Mazotti TA; Faculdade de Ciências Farmacêuticas, Universidade de São Paulo - São Paulo (SP), Brasil.
Silva NAO; Departamento de Ciências Farmacêuticas, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo - Diadema (SP), Brasil.
Stein AT; Universidade Federal de Ciências da Saúde de Porto Alegre - Porto Alegre (RS), Brasil.
Diaz-Quijano FA; Departamento de Epidemiologia, Laboratório de Inferência Causal em Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo - São Paulo (SP), Brasil.
Melo DO; Departamento de Ciências Farmacêuticas, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo - Diadema (SP), Brasil.
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Transliterated Title :
Avaliação da resposta inicial de desenvolvimento de ensaios clínicos para COVID-19 no Brasil.
Źródło :
Revista brasileira de epidemiologia = Brazilian journal of epidemiology [Rev Bras Epidemiol] 2021 Jan 06; Vol. 23, pp. e200104. Date of Electronic Publication: 2021 Jan 06 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Clinical Trials as Topic*
COVID-19/*drug therapy
Brazil ; Humans ; Prospective Studies ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Tytuł :
Making Compassionate Use More Useful: Using real-world data, real-world evidence and digital twins to supplement or supplant randomized controlled trials.
Autorzy :
Greenbaum D; Zvi Meitar Institute for Legal Implications of Emerging Technologies, IDC Herzliya, Herzliya, Israel2Harry Radzyner Law School, IDC Herzliya, Herzliya, Israel3Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA, .
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Źródło :
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing [Pac Symp Biocomput] 2021; Vol. 26, pp. 38-49.
Typ publikacji :
Journal Article
MeSH Terms :
Compassionate Use Trials*
Pharmaceutical Preparations*
Computational Biology ; Humans ; Randomized Controlled Trials as Topic ; United States ; United States Food and Drug Administration
Czasopismo naukowe
Tytuł :
Current Issues in Conduct and Reporting of Noninferiority Randomized Controlled Trials in Surgical Management of Cancer Patients.
Autorzy :
Parsyan A; Department of Surgery and Oncology, London Regional Cancer Program, St Joseph's Health Care and London Health Sciences Centre, Western University, London, ON, Canada. .
Marini W; Department of Surgery, University Health Network, Princess Margaret Hospital, University of Toronto, Toronto, Canada.
Fazelzad R; Library and Information Services, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Moher D; Centre for Journalology, Ottawa Hospital Research Institute, Ottawa, Canada.; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.
McCready D; Department of Surgery, University Health Network, Princess Margaret Hospital, University of Toronto, Toronto, Canada.
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Źródło :
Annals of surgical oncology [Ann Surg Oncol] 2021 Jan; Vol. 28 (1), pp. 39-47. Date of Electronic Publication: 2020 May 19.
Typ publikacji :
Journal Article
MeSH Terms :
Neoplasms*/surgery
Randomized Controlled Trials as Topic*
Cross-Sectional Studies ; Equivalence Trials as Topic ; Humans
Czasopismo naukowe
Tytuł :
Data monitoring committees for clinical trials evaluating treatments of COVID-19.
Autorzy :
Mütze T; Statistical Methodology, Novartis Pharma AG, Basel, Switzerland.
Friede T; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany; DZHK (German Center for Cardiovascular Research), partner site Göttingen, Göttingen, Germany. Electronic address: .
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Źródło :
Contemporary clinical trials [Contemp Clin Trials] 2020 Nov; Vol. 98, pp. 106154. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19 Testing*
Clinical Trials Data Monitoring Committees*/organization & administration
Clinical Trials Data Monitoring Committees*/standards
Clinical Trials Data Monitoring Committees*/trends
Vaccination*
COVID-19/*drug therapy
Research Design/*trends
COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/prevention & control ; Computer Simulation ; Ethics Committees, Research ; Humans ; Randomized Controlled Trials as Topic/ethics ; Randomized Controlled Trials as Topic/methods ; Randomized Controlled Trials as Topic/statistics & numerical data ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Assessment of Length and Readability of Informed Consent Documents for COVID-19 Vaccine Trials.
Autorzy :
Emanuel EJ; Department of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Boyle CW; Department of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
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Źródło :
JAMA network open [JAMA Netw Open] 2021 Apr 01; Vol. 4 (4), pp. e2110843. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19 Vaccines*
Comprehension*
Informed Consent*
Language*
COVID-19/*prevention & control
Clinical Trials as Topic/*methods
Consent Forms/*standards
Clinical Trials, Phase III as Topic ; Humans ; Randomized Controlled Trials as Topic ; Reading ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
COVID-19 clinical trials: learning from exceptions in the research chaos.
Autorzy :
Tikkinen KAO; Departments of Urology and Public Health, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Surgery, South Karelian Central Hospital, Lappeenranta, Finland.
Malekzadeh R; Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Schlegel M; Department of Anesthesiology and Intensive Care, Technical University of Munich School of Medicine, Munich, Germany.
Rutanen J; Department of Internal Medicine, Tampere University Hospital, Tampere, Finland.
Glasziou P; Institute for Evidence-Based Healthcare, Bond University, Robina, Australia. .
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Źródło :
Nature medicine [Nat Med] 2020 Nov; Vol. 26 (11), pp. 1671-1672.
Typ publikacji :
Historical Article; Letter
MeSH Terms :
Clinical Trials as Topic*/methods
Clinical Trials as Topic*/organization & administration
Clinical Trials as Topic*/standards
Pandemics*/history
Biomedical Research/*organization & administration
COVID-19/*therapy
Biomedical Research/history ; Biomedical Research/standards ; COVID-19/diagnosis ; COVID-19/epidemiology ; Canada/epidemiology ; Community Networks/organization & administration ; Community Networks/standards ; Drug Evaluation, Preclinical/methods ; Drug Evaluation, Preclinical/standards ; Europe/epidemiology ; History, 21st Century ; Humans ; International Cooperation ; Learning ; Neural Networks, Computer ; Organizational Innovation ; Patient Selection ; Pragmatic Clinical Trials as Topic/methods ; Pragmatic Clinical Trials as Topic/standards ; Research Design ; Scandinavian and Nordic Countries/epidemiology ; United Kingdom/epidemiology ; World Health Organization/organization & administration
Opinia redakcyjna
Tytuł :
Characteristics of oncological clinical trials submitted to the Instituto Nacional de Salud del Peru, 1995-2019.
Autorzy :
Cahuina-Lope P; Instituto Nacional de Salud, Lima, Perú.
Solis-Sánchez G; Departamento de Estadística, Demografía, Humanidades y Ciencias Sociales, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.
Espíritu N; Instituto Nacional de Salud, Lima, Perú.
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Transliterated Title :
Características de los ensayos clínicos oncológicos presentados al Instituto Nacional de Salud del Perú, 1995-2019.
Źródło :
Revista peruana de medicina experimental y salud publica [Rev Peru Med Exp Salud Publica] 2020 Oct-Dec; Vol. 37 (4), pp. 739-745. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Clinical Trials as Topic*/statistics & numerical data
Neoplasms*/therapy
Clinical Trials, Phase III as Topic ; Humans ; Peru ; Randomized Controlled Trials as Topic ; Registries ; Research Design/statistics & numerical data
Czasopismo naukowe
Tytuł :
Protocol adherence rates in superiority and noninferiority randomized clinical trials published in high impact medical journals.
Autorzy :
Bamat NA; Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Center for Pediatric Clinical Effectiveness, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ekhaguere OA; Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Indiana University, Indianapolis, IN, USA.
Zhang L; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Biosense Webster, Inc., Irvine, CA, USA.
Flannery DD; Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Center for Pediatric Clinical Effectiveness, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Handley SC; Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA.
Herrick HM; Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Center for Pediatric Clinical Effectiveness, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ellenberg SS; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
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Źródło :
Clinical trials (London, England) [Clin Trials] 2020 Oct; Vol. 17 (5), pp. 552-559. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Equivalence Trials as Topic*
Periodicals as Topic*
Guideline Adherence/*statistics & numerical data
Randomized Controlled Trials as Topic/*methods
Humans ; Intention to Treat Analysis ; Journal Impact Factor ; Randomized Controlled Trials as Topic/statistics & numerical data ; Research Design ; Sample Size
Czasopismo naukowe
Tytuł :
Clinical trials in a COVID-19 pandemic: Shared infrastructure for continuous learning in a rapidly changing landscape.
Autorzy :
Hedlin H; Quantitative Sciences Unit, Division of Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Garcia A; Quantitative Sciences Unit, Division of Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Weng Y; Quantitative Sciences Unit, Division of Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
He Z; Sean N. Parker Center for Allergy and Asthma Research, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Sundaram V; Quantitative Sciences Unit, Division of Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Bunning B; Quantitative Sciences Unit, Division of Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Balasubramanian V; Quantitative Sciences Unit, Division of Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Cunanan K; Quantitative Sciences Unit, Division of Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Kapphahn K; Quantitative Sciences Unit, Division of Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Gummidipundi S; Quantitative Sciences Unit, Division of Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Purington N; Quantitative Sciences Unit, Division of Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Boulos M; Quantitative Sciences Unit, Division of Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Desai M; Quantitative Sciences Unit, Division of Biomedical Informatics Research, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
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Źródło :
Clinical trials (London, England) [Clin Trials] 2021 Jun; Vol. 18 (3), pp. 324-334. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Pandemics*
COVID-19/*therapy
Clinical Trials as Topic/*methods
Clinical Trial Protocols as Topic ; Clinical Trials Data Monitoring Committees ; Endpoint Determination ; Humans ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
COVID-19 vaccine trials: The use of active controls and non-inferiority studies.
Autorzy :
Fleming TR; Department of Biostatistics, University of Washington, Seattle, WA, USA.
Krause PR; Office of Vaccines Research and Review, FDA/CBER, Silver Spring, MD, USA.
Nason M; National Institute of Allergy and Infectious Diseases (NIAID/NIH), Bethesda, MD, USA.
Longini IM; Department of Biostatistics, University of Florida, Gainesville, FL, USA.
Henao-Restrepo AM; World Health Organization, Geneva, Switzerland.
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Źródło :
Clinical trials (London, England) [Clin Trials] 2021 Jun; Vol. 18 (3), pp. 335-342. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
COVID-19/*prevention & control
COVID-19 Vaccines/*therapeutic use
Randomized Controlled Trials as Topic/*methods
Equivalence Trials as Topic ; Humans ; Pandemics/prevention & control ; SARS-CoV-2 ; Sample Size ; Single-Blind Method ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Meta-analysis of noninferiority and equivalence trials: ignoring trial design leads to differing and possibly misleading conclusions.
Autorzy :
Acuna SA; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Dossa F; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Baxter N; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia; Division of General Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address: .
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Źródło :
Journal of clinical epidemiology [J Clin Epidemiol] 2020 Nov; Vol. 127, pp. 134-141. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Equivalence Trials as Topic*
Meta-Analysis as Topic*
Research Design*
Bias ; Bibliometrics ; Cross-Sectional Studies ; Humans ; Randomized Controlled Trials as Topic/statistics & numerical data
Czasopismo naukowe
Tytuł :
Describing deprescribing trials better: an elaboration of the CONSORT statement.
Autorzy :
Blom JW; Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: .
Muth C; Institute of General Practice, Goethe University Frankfurt/Main, Frankfurt am Main, Germany.
Glasziou P; Institute for Evidence-Based Healthcare, Faculty of Health Sciences & Medicine, Bond University, Gold Coast, Australia.
McCormack JP; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Perera R; Nuffield Department of Primary Care Health Sciences, Medical Statistics, University of Oxford, Oxford, UK.
Poortvliet RKE; Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Numans ME; Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Thürmann P; Department of Clinical Pharmacology, University of Witten/Herdecke, Helios University Hospital Wuppertal, Witten, Germany.
Thiem U; Centre of Geriatrics and Gerontology, Albertinen-Haus, Hamburg, Germany; Geriatrics and Gerontology, University Medical Centre Eppendorf, Hamburg, Germany.
Thio SL; Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Van Driel M; Faculty of Medicine, Primary Care Clinical Unit, The University of Queensland, Brisbane, Australia.
Beyer M; Institute of General Practice, Goethe University Frankfurt/Main, Frankfurt am Main, Germany.
Van den Akker M; Institute of General Practice, Goethe University Frankfurt/Main, Frankfurt am Main, Germany; Department of General Practice, Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands.
Knottnerus JA; Department of General Practice, Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands.
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Źródło :
Journal of clinical epidemiology [J Clin Epidemiol] 2020 Nov; Vol. 127, pp. 87-95. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Deprescriptions*
Guidelines as Topic*
Randomized Controlled Trials as Topic*
Research Report/*standards
Checklist ; Delphi Technique ; Drug-Related Side Effects and Adverse Reactions ; Equivalence Trials as Topic ; Humans ; Placebos/therapeutic use ; Research Design
Czasopismo naukowe
Tytuł :
Seven decades of chemotherapy clinical trials: a pan-cancer social network analysis.
Autorzy :
Li X; Vanderbilt University, Nashville, TN, USA.
Sigworth EA; Vanderbilt University, Nashville, TN, USA.
Wu AH; Mount Holyoke College, South Hadley, MA, USA.
Behrens J; Vanderbilt University, Nashville, TN, USA.
Etemad SA; Vanderbilt University, Nashville, TN, USA.
Nagpal S; Stanford University, Palo Alto, CA, USA.
Go RS; Mayo Clinic, Rochester, MN, USA.
Wuichet K; Vanderbilt University Medical Center, 2220 Pierce Ave, PRB 777, Nashville, TN, 37232, USA.
Chen EJ; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Rubinstein SM; Vanderbilt University Medical Center, 2220 Pierce Ave, PRB 777, Nashville, TN, 37232, USA.
Venepalli NK; University of Illinois at Chicago, Chicago, IL, USA.
Tillman BF; Vanderbilt University Medical Center, 2220 Pierce Ave, PRB 777, Nashville, TN, 37232, USA.
Cowan AJ; University of Washington, Seattle, WA, USA.
Schoen MW; Saint Louis University, St. Louis, MO, USA.
Malty A; Stanford University, Palo Alto, CA, USA.
Greer JP; Vanderbilt University Medical Center, 2220 Pierce Ave, PRB 777, Nashville, TN, 37232, USA.
Fernandes HD; University of North Dakota, Grand Forks, ND, USA.
Seifter A; University of Illinois at Chicago, Chicago, IL, USA.
Chen Q; Vanderbilt University, Nashville, TN, USA.
Chowdhery RA; University of Illinois at Chicago, Chicago, IL, USA.
Mohan SR; Vanderbilt University Medical Center, 2220 Pierce Ave, PRB 777, Nashville, TN, 37232, USA.
Dewdney SB; Rush University, Chicago, IL, USA.
Osterman T; Vanderbilt University Medical Center, 2220 Pierce Ave, PRB 777, Nashville, TN, 37232, USA.
Ambinder EP; Mount Sinai Medical Center, New York, NY, USA.
Buchbinder EI; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Schwartz C; University of Illinois at Chicago, Chicago, IL, USA.
Abraham I; University of Illinois at Chicago, Chicago, IL, USA.
Rioth MJ; University of Colorado, Denver, CO, USA.
Singh N; University of Illinois at Chicago, Chicago, IL, USA.
Sharma S; Sequoia Regional Cancer Center, Visalia, CA, USA.
Gibson MK; Vanderbilt University Medical Center, 2220 Pierce Ave, PRB 777, Nashville, TN, 37232, USA.
Yang PC; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Warner JL; Vanderbilt University Medical Center, 2220 Pierce Ave, PRB 777, Nashville, TN, 37232, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Oct 16; Vol. 10 (1), pp. 17536. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Historical Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Clinical Trials as Topic*
Social Network Analysis*
Antineoplastic Agents/*therapeutic use
Medical Oncology/*history
Neoplasms/*drug therapy
Publishing/*trends
Algorithms ; Authorship ; Female ; History, 20th Century ; History, 21st Century ; Humans ; Male ; Prospective Studies ; Randomized Controlled Trials as Topic ; Research Design ; Research Personnel
Czasopismo naukowe
Tytuł :
Application of methylene blue -vitamin C -N-acetyl cysteine for treatment of critically ill COVID-19 patients, report of a phase-I clinical trial.
Autorzy :
Alamdari DH; Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: .
Moghaddam AB; Department of Anaesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Amini S; Anaesthesiology and Critical Care Lung Research Center, Faculty of Medicine, Mashhad, Iran.
Keramati MR; Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Zarmehri AM; ICU Department, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Alamdari AH; Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Damsaz M; Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Banpour H; Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Yarahmadi A; Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Koliakos G; Department of Biochemistry, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 Oct 15; Vol. 885, pp. 173494. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Clinical Trials, Phase I as Topic*
Critical Illness*
Acetylcysteine/*therapeutic use
Ascorbic Acid/*therapeutic use
Coronavirus Infections/*drug therapy
Methylene Blue/*therapeutic use
Pneumonia, Viral/*drug therapy
COVID-19 ; Compassionate Use Trials ; Coronavirus Infections/complications ; Female ; Humans ; Hypoxia/complications ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications
Czasopismo naukowe
Tytuł :
Clinical trials of disease stages in COVID 19: complicated and often misinterpreted.
Autorzy :
Park JJH; Department of Experimental Medicine, University of British Columbia, Vancouver, BC, Canada.
Decloedt EH; Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Rayner CR; Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia; Certara, Princeton, NJ, USA.
Cotton M; Family Clinical Research Unit, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, University of Stellenbosch, Tygerberg, South Africa.
Mills EJ; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada. Electronic address: .
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Źródło :
The Lancet. Global health [Lancet Glob Health] 2020 Oct; Vol. 8 (10), pp. e1249-e1250. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article
MeSH Terms :
Clinical Trials as Topic*
Coronavirus Infections/*physiopathology
Pneumonia, Viral/*physiopathology
COVID-19 ; Coronavirus Infections/drug therapy ; Data Interpretation, Statistical ; Humans ; Pandemics ; Randomized Controlled Trials as Topic ; Research Design ; Treatment Outcome
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe

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