- Tytuł:
-
Comparison of the hepatic metabolism of
triazolam in wild-type andCyp3a-knockout mice for understanding CYP3A-mediated metabolism inCYP3A-humanised mice in vivo . - Autorzy:
- Źródło:
- Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Nov; Vol. 49 (11), pp. 1303-1310. Date of Electronic Publication: 2019 Jun 14.
- Typ publikacji:
- Comparative Study; Journal Article; Video-Audio Media
- MeSH Terms:
-
Cytochrome P-450 CYP3A/*metabolism
Triazolam /*pharmacokinetics
Animals ; Area Under Curve ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Gene Expression Regulation, Enzymologic ; Humans ; Liver/drug effects ; Liver/metabolism ; Male ; Mice, Inbred ICR ; Mice, Knockout ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Pregnenolone Carbonitrile/blood ; Pregnenolone Carbonitrile/pharmacokinetics ;Triazolam /blood ;Triazolam /metabolism
Czasopismo naukowe