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Tytuł :
A two years field experiment to assess the impact of two fungicides on earthworm communities and their recovery.
Autorzy :
Amossé J; Université Paris-Saclay, INRAE, AgroParisTech, UMR ECOSYS, 78026, Versailles, France.
Bart S; Université Paris-Saclay, INRAE, AgroParisTech, UMR ECOSYS, 78026, Versailles, France.
Brulle F; Ecotoxicological and Environmental Fate Unit for Pesticides and Fertilisers, Regulated Products Assessment Department, ANSES, 94700, Maisons-Alfort, France.
Tebby C; Models for Ecotoxicology and Toxicology Unit, INERIS, 60550, Verneuil-en-Halatte, France.
Beaudouin R; Models for Ecotoxicology and Toxicology Unit, INERIS, 60550, Verneuil-en-Halatte, France.
Nélieu S; Université Paris-Saclay, INRAE, AgroParisTech, UMR ECOSYS, 78850, Thiverval-Grignon, France.
Lamy I; Université Paris-Saclay, INRAE, AgroParisTech, UMR ECOSYS, 78026, Versailles, France.
Péry ARR; Université Paris-Saclay, INRAE, AgroParisTech, UMR ECOSYS, 78026, Versailles, France.
Pelosi C; Université Paris-Saclay, INRAE, AgroParisTech, UMR ECOSYS, 78026, Versailles, France; INRAE, Avignon Université, UMR EMMAH, F-84000, Avignon, France. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Oct 15; Vol. 203, pp. 110979. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Copper/*toxicity
Environmental Monitoring/*methods
Epoxy Compounds/*toxicity
Fungicides, Industrial/*toxicity
Oligochaeta/*drug effects
Soil Pollutants/*toxicity
Triazoles/*toxicity
Animals ; Biodiversity ; Biomass ; Copper/analysis ; Ecotoxicology ; Epoxy Compounds/analysis ; Fungicides, Industrial/analysis ; Oligochaeta/growth & development ; Risk Assessment ; Soil/chemistry ; Soil Pollutants/analysis ; Triazoles/analysis
Czasopismo naukowe
Tytuł :
Non-GABA sleep medications, suvorexant as risk factors for falls: Case-control and case-crossover study.
Autorzy :
Ishibashi Y; Department of Internal Medicine, Kudanzaka Hospital, Company Overview of Federation of National Public Service Personnel Mutual Aid Associations, Chiyoda-ku, Tokyo, Japan.; Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
Nishitani R; Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
Shimura A; Department of Psychiatry, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.; Department of Sleep and Psychiatry, Kanno Hospital, Wako-shi, Saitama, Japan.
Takeuchi A; Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
Touko M; Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
Kato T; Department of Pharmacy, Kudanzaka Hospital, Company Overview of Federation of National Public Service Personnel Mutual Aid Associations, Chiyoda-ku, Tokyo, Japan.
Chiba S; Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
Ashidate K; Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
Ishiwata N; Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
Ichijo T; Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
Sasabe M; Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
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Źródło :
PloS one [PLoS One] 2020 Sep 11; Vol. 15 (9), pp. e0238723. Date of Electronic Publication: 2020 Sep 11 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Accidental Falls*
Azepines/*adverse effects
Indenes/*adverse effects
Sleep Aids, Pharmaceutical/*adverse effects
Triazoles/*adverse effects
Aged ; Aged, 80 and over ; Azepines/administration & dosage ; Benzodiazepines/administration & dosage ; Benzodiazepines/adverse effects ; Cross-Over Studies ; Female ; Humans ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/adverse effects ; Indenes/administration & dosage ; Male ; Middle Aged ; Risk Factors ; Sleep/drug effects ; Sleep/physiology ; Triazoles/administration & dosage
Czasopismo naukowe
Tytuł :
Does Canavalia ensiformis inoculation with Bradyrhizobium sp. enhance phytoremediation of sulfentrazone-contaminated soil?
Autorzy :
Mielke KC; Federal University of Viçosa, Department of Agronomy, Av. P.H. Rolfs, s/n, Viçosa, 36570-900, MG, Brazil. Electronic address: .
Bertuani RR; Federal University of Espiríto Santo, Department of Biological and Agriculture Science, Rodovia BR 101 Norte, Litoranêao s/n, São Mateus, 29932-540, ES, Brazil.
Pires FR; Federal University of Espiríto Santo, Department of Biological and Agriculture Science, Rodovia BR 101 Norte, Litoranêao s/n, São Mateus, 29932-540, ES, Brazil.
Bueno Cotta AJ; Federal University of Espiríto Santo, Department of Natural Sciences, Rodovia BR 101 Norte, Litoranêao s/n, São Mateus, 29932-540, ES, Brazil.
Egreja Filho FB; Federal University of Minas Gerais, Departament of Chemistry, Institute of Exact Sciences, Belo Horizonte, 31270-901, MG, Brazil.
Madalão JC; Federal University of Viçosa, Department of Agronomy, Av. P.H. Rolfs, s/n, Viçosa, 36570-900, MG, Brazil.
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Źródło :
Chemosphere [Chemosphere] 2020 Sep; Vol. 255, pp. 127033. Date of Electronic Publication: 2020 May 10.
Typ publikacji :
Journal Article
MeSH Terms :
Soil Microbiology*
Bradyrhizobium/*growth & development
Canavalia/*growth & development
Herbicides/*analysis
Soil Pollutants/*analysis
Sulfonamides/*analysis
Triazoles/*analysis
Biodegradation, Environmental ; Herbicides/metabolism ; Soil/chemistry ; Soil Pollutants/metabolism ; Sulfonamides/metabolism ; Symbiosis ; Triazoles/metabolism
Czasopismo naukowe
Tytuł :
Integrated safety profile of selinexor in multiple myeloma: experience from 437 patients enrolled in clinical trials.
Autorzy :
Gavriatopoulou M; Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. .
Chari A; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Chen C; Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, Toronto, ON, Canada.
Bahlis N; Charbonneau Cancer Research Institute, Calgary, AB, Canada.
Vogl DT; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jakubowiak A; University of Chicago Medical Center, Chicago, IL, USA.
Dingli D; Mayo Clinic, Rochester, MN, USA.
Cornell RF; Vanderbilt University Medical Center, Nashville, TN, USA.
Hofmeister CC; Department of Internal Medicine, Division of Hematology, The Ohio State University, Columbus, OH, USA.
Siegel D; Department of Hematology, John Theurer Cancer Center, Hackensack, NJ, USA.
Berdeja JG; Sarah Cannon Research Institute, Nashville, TN, USA.
Reece D; Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, Toronto, ON, Canada.
White D; QEII Health Sciences Center, Dalhousie University, Halifax, NS, Canada.
Lentzsch S; Department of Medicine, Division of Hematology/Oncology, Columbia University, New York, NY, USA.
Gasparetto C; Duke University Cancer Center, Durham, NC, USA.
Huff CA; Johns Hopkins University, Baltimore, MD, USA.
Jagannath S; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Baz R; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Nooka AK; Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Richter J; Department of Hematology, John Theurer Cancer Center, Hackensack, NJ, USA.
Abonour R; Indiana University Cancer Center, Indianapolis, IN, USA.
Parker TL; Yale School of Medicine, New Haven, CT, USA.
Yee AJ; Massachusetts General Hospital Cancer Center, Boston, MA, USA.
Moreau P; University of Nantes, Nantes, France.
Lonial S; Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Tuchman S; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Weisel KC; University Medical Center of Hamburg-Eppendorf, Hamburg, Germany.
Mohty M; Hôpital Saint Antoine, Paris, France.
Choquet S; La Pitié-Salpêtrière Hospital, Paris, France.
Unger TJ; Karyopharm Therapeutics, Newton, MA, USA.
Li K; Karyopharm Therapeutics, Newton, MA, USA.
Chai Y; Karyopharm Therapeutics, Newton, MA, USA.
Li L; Karyopharm Therapeutics, Newton, MA, USA.
Shah J; Karyopharm Therapeutics, Newton, MA, USA.
Shacham S; Karyopharm Therapeutics, Newton, MA, USA.
Kauffman MG; Karyopharm Therapeutics, Newton, MA, USA.
Dimopoulos MA; Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
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Źródło :
Leukemia [Leukemia] 2020 Sep; Vol. 34 (9), pp. 2430-2440. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
Clinical Trials as Topic*
Antineoplastic Agents/*adverse effects
Hydrazines/*adverse effects
Multiple Myeloma/*drug therapy
Triazoles/*adverse effects
Aged ; Antineoplastic Agents/therapeutic use ; Appetite/drug effects ; Diarrhea/chemically induced ; Fatigue/chemically induced ; Fatigue/drug therapy ; Female ; Humans ; Hydrazines/therapeutic use ; Hyponatremia/chemically induced ; Hyponatremia/therapy ; Male ; Middle Aged ; Nausea/chemically induced ; Nausea/drug therapy ; Thrombocytopenia/chemically induced ; Triazoles/therapeutic use
Czasopismo naukowe
Tytuł :
Design, synthesis and biological evaluation of novel 1 H -1,2,4-triazole, benzothiazole and indazole-based derivatives as potent FGFR1 inhibitors via fragment-based virtual screening.
Autorzy :
Liu J; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Wen Y; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Gao L; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Gao L; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
He F; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Zhou J; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Wang J; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Dai R; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Chen X; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Kang D; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Hu L; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 72-84.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Benzothiazoles/*pharmacology
Indazoles/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Receptor, Fibroblast Growth Factor, Type 1/*antagonists & inhibitors
Triazoles/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Benzothiazoles/chemical synthesis ; Benzothiazoles/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Indazoles/chemical synthesis ; Indazoles/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Receptor, Fibroblast Growth Factor, Type 1/metabolism ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/chemistry
Czasopismo naukowe
Tytuł :
Effects of post-renal anemia treatment with the HIF-PHD inhibitor molidustat on adenine-induced renal anemia and kidney disease in mice.
Autorzy :
Li L; Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan.
Nakano D; Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan. Electronic address: .
Zhang A; Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan.
Kittikulsuth W; Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan.
Morisawa N; Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan.
Ohsaki H; Laboratory of Pathology, Department of Medical Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan.
Suzuki N; Division of Oxygen Biology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yamamoto M; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Nishiyama A; Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan.
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Źródło :
Journal of pharmacological sciences [J Pharmacol Sci] 2020 Dec; Vol. 144 (4), pp. 229-236. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Prolyl-Hydroxylase Inhibitors*
Acute Kidney Injury/*chemically induced
Acute Kidney Injury/*complications
Adenine/*adverse effects
Anemia/*drug therapy
Anemia/*etiology
Hypoxia-Inducible Factor 1/*antagonists & inhibitors
Pyrazoles/*therapeutic use
Triazoles/*therapeutic use
Acute Kidney Injury/metabolism ; Animals ; Disease Models, Animal ; Erythropoietin/metabolism ; Male ; Mice, Inbred C57BL ; Pyrazoles/administration & dosage ; Pyrazoles/pharmacology ; Triazoles/administration & dosage ; Triazoles/pharmacology
Czasopismo naukowe
Tytuł :
Developmental reproductive toxicity and endocrine activity of propiconazole in the Xenopus tropicalis model.
Autorzy :
Svanholm S; Department of Environmental Toxicology, Uppsala University, Centre for Reproductive Biology in Uppsala (CRU), Sweden. Electronic address: .
Säfholm M; Department of Environmental Toxicology, Uppsala University, Centre for Reproductive Biology in Uppsala (CRU), Sweden.
Brande-Lavridsen N; Department of Environmental Toxicology, Uppsala University, Centre for Reproductive Biology in Uppsala (CRU), Sweden.
Larsson E; Department of Environmental Toxicology, Uppsala University, Centre for Reproductive Biology in Uppsala (CRU), Sweden.
Berg C; Department of Environmental Toxicology, Uppsala University, Centre for Reproductive Biology in Uppsala (CRU), Sweden.
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Źródło :
The Science of the total environment [Sci Total Environ] 2021 Jan 20; Vol. 753, pp. 141940. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article
MeSH Terms :
Endocrine Disruptors*/toxicity
Triazoles*/toxicity
Animals ; Humans ; Larva ; Male ; Metamorphosis, Biological ; Reproduction ; Xenopus
Czasopismo naukowe
Tytuł :
Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor.
Autorzy :
Waaler J; Hybrid Technology Hub-Centre of Excellence, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1110 Blindern, 0317 Oslo, Norway.; Department of Immunology and Transfusion Medicine, Oslo University Hospital, P.O. Box 4950 Nydalen, 0424 Oslo, Norway.
Leenders RGG; Mercachem BV, Kerkenbos 1013, 6546 BB Nijmegen, The Netherlands.
Sowa ST; Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, P.O. Box 5400, 90014 Oulu, Finland.
Alam Brinch S; Hybrid Technology Hub-Centre of Excellence, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1110 Blindern, 0317 Oslo, Norway.; Department of Immunology and Transfusion Medicine, Oslo University Hospital, P.O. Box 4950 Nydalen, 0424 Oslo, Norway.
Lycke M; Hybrid Technology Hub-Centre of Excellence, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1110 Blindern, 0317 Oslo, Norway.; Department of Immunology and Transfusion Medicine, Oslo University Hospital, P.O. Box 4950 Nydalen, 0424 Oslo, Norway.
Nieczypor P; Mercachem BV, Kerkenbos 1013, 6546 BB Nijmegen, The Netherlands.
Aertssen S; Mercachem BV, Kerkenbos 1013, 6546 BB Nijmegen, The Netherlands.
Murthy S; Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, P.O. Box 5400, 90014 Oulu, Finland.
Galera-Prat A; Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, P.O. Box 5400, 90014 Oulu, Finland.
Damen E; Mercachem BV, Kerkenbos 1013, 6546 BB Nijmegen, The Netherlands.
Wegert A; Mercachem BV, Kerkenbos 1013, 6546 BB Nijmegen, The Netherlands.
Nazaré M; Medicinal Chemistry, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Campus Berlin Buch, Robert-Roessle-Straße 10, 13125 Berlin, Germany.
Lehtiö L; Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, P.O. Box 5400, 90014 Oulu, Finland.
Krauss S; Hybrid Technology Hub-Centre of Excellence, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1110 Blindern, 0317 Oslo, Norway.; Department of Immunology and Transfusion Medicine, Oslo University Hospital, P.O. Box 4950 Nydalen, 0424 Oslo, Norway.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Jul 09; Vol. 63 (13), pp. 6834-6846. Date of Electronic Publication: 2020 Jun 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Poly(ADP-ribose) Polymerase Inhibitors/*chemistry
Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology
Tankyrases/*antagonists & inhibitors
Triazoles/*chemistry
Triazoles/*pharmacology
Animals ; Biological Availability ; Caco-2 Cells ; Cell Proliferation/drug effects ; Humans ; Mice ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacokinetics ; Solubility ; Triazoles/pharmacokinetics
Czasopismo naukowe
Tytuł :
A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents.
Autorzy :
Sultan A; Division of Science and Technology, Department of Chemistry, University of Education, Lahore, Pakistan.
Ur Rehman MH; Division of Science and Technology, Department of Chemistry, University of Education, Lahore, Pakistan.
Sajjad N; Department of Chemistry, University of Lahore, Lahore, Pakistan.
Irfan A; Department of Chemistry, University of Lahore Sargodha campus, Sargodha, Pakistan.
Ullah I; Department of Chemistry, University of Sargodha Sub-campus Bhakkar, Bhakkar, Pakistan.
Mustaqeem M; Department of Chemistry, University of Sargodha Sub-campus Bhakkar, Bhakkar, Pakistan.
Saleem M; Department of Chemistry, University of Sargodha Sub-campus Bhakkar, Bhakkar, Pakistan.
Rubab SL; Division of Science and Technology, Department of Chemistry, University of Education, Lahore, Pakistan.
Rafiq M; Department of Physiology and Biochemistry, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan.
Khalid M; Department of Chemistry, Khwaja Ghulam Fareed University of Science and Technology, Rahimyar Khan, Pakistan.
Kotwica-Mojzych K; Chair and Department of Histology, Embryology and Cytophisiology, Medical University of Lublin, (Collegium Medicum), Lublin, Poland.
Mojzych M; Department of Chemistry, Siedlce University of Natural Sciences and Humanities, Siedlce, Poland.
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Źródło :
PloS one [PLoS One] 2020 Jun 04; Vol. 15 (6), pp. e0229891. Date of Electronic Publication: 2020 Jun 04 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ultrasonic Waves*
Amitrole/*chemical synthesis
Amitrole/*pharmacology
Anti-Bacterial Agents/*chemical synthesis
Anti-Bacterial Agents/*pharmacology
Triazoles/*chemical synthesis
Triazoles/*pharmacology
Amitrole/chemistry ; Anti-Bacterial Agents/chemistry ; Bacteria/drug effects ; Chemistry Techniques, Synthetic ; Microbial Sensitivity Tests ; Schiff Bases/chemistry ; Triazoles/chemistry
Czasopismo naukowe
Tytuł :
Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors.
Autorzy :
Zaher NH; Radiation Drug Research Department National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
Mostafa MI; Department of Pharmacology, College of Veterinary Medicine, Cairo University, Gizah, Egypt.
Altaher AY; Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, King Faisal University Alhasa, Kingdom of Saudi Arabia.
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Źródło :
Acta pharmaceutica (Zagreb, Croatia) [Acta Pharm] 2020 Jun 01; Vol. 70 (2), pp. 145-159.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Computer-Aided Design*
Drug Design*
Molecular Docking Simulation*
Antiviral Agents/*pharmacology
Coronavirus Infections/*drug therapy
DNA Helicases/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Middle East Respiratory Syndrome Coronavirus/*drug effects
Triazoles/*pharmacology
Viral Proteins/*antagonists & inhibitors
Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/metabolism ; Coronavirus Infections/virology ; DNA Helicases/chemistry ; DNA Helicases/metabolism ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/metabolism ; Humans ; Middle East Respiratory Syndrome Coronavirus/enzymology ; Middle East Respiratory Syndrome Coronavirus/growth & development ; Molecular Structure ; Protein Binding ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/metabolism ; Viral Proteins/chemistry ; Viral Proteins/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Selinexor: A First-in-Class Nuclear Export Inhibitor for Management of Multiply Relapsed Multiple Myeloma.
Autorzy :
Peterson TJ; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Orozco J; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Buege M; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
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Źródło :
The Annals of pharmacotherapy [Ann Pharmacother] 2020 Jun; Vol. 54 (6), pp. 577-582. Date of Electronic Publication: 2019 Dec 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Cell Nucleus/*drug effects
Hydrazines/*therapeutic use
Karyopherins/*antagonists & inhibitors
Multiple Myeloma/*drug therapy
Plasma Cells/*drug effects
Receptors, Cytoplasmic and Nuclear/*antagonists & inhibitors
Triazoles/*therapeutic use
Active Transport, Cell Nucleus/drug effects ; Animals ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics ; Cell Nucleus/metabolism ; Female ; Humans ; Hydrazines/administration & dosage ; Hydrazines/adverse effects ; Hydrazines/pharmacokinetics ; Male ; Multiple Myeloma/metabolism ; Multiple Myeloma/pathology ; Plasma Cells/metabolism ; Plasma Cells/pathology ; Recurrence ; Triazoles/administration & dosage ; Triazoles/adverse effects ; Triazoles/pharmacokinetics
Czasopismo naukowe
Tytuł :
Biological exploration of a novel 1,2,4-triazole-indole hybrid molecule as antifungal agent.
Autorzy :
Pagniez F; Département de Parasitologie et Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155 - IICiMed, Institut de Recherche en Santé 2, Nantes, France.
Lebouvier N; Département de Chimie Thérapeutique, Université de Nantes, Nantes Atlantique Universités, EA1155 - IICiMed, Institut de Recherche en Santé 2, Nantes, France.; Institut des Sciences Exactes et Appliquées (ISEA) - EA 7484, Université de la Nouvelle-Calédonie, Noumea Cedex, New Caledonia.
Na YM; Département de Chimie Thérapeutique, Université de Nantes, Nantes Atlantique Universités, EA1155 - IICiMed, Institut de Recherche en Santé 2, Nantes, France.
Ourliac-Garnier I; Département de Parasitologie et Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155 - IICiMed, Institut de Recherche en Santé 2, Nantes, France.
Picot C; Département de Parasitologie et Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155 - IICiMed, Institut de Recherche en Santé 2, Nantes, France.
Le Borgne M; Département de Chimie Thérapeutique, Université de Nantes, Nantes Atlantique Universités, EA1155 - IICiMed, Institut de Recherche en Santé 2, Nantes, France.; EA 4446 Bioactive Molecules and Medicinal Chemistry, Faculté de Pharmacie - ISPB, SFR Santé Lyon-Est CNRS UMS3453 - INSERM US7, Université de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Le Pape P; Département de Parasitologie et Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155 - IICiMed, Institut de Recherche en Santé 2, Nantes, France.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 398-403.
Typ publikacji :
Journal Article
MeSH Terms :
Antifungal Agents/*pharmacology
Candida/*drug effects
Indoles/*pharmacology
Triazoles/*pharmacology
Animals ; Antifungal Agents/chemistry ; Candida/enzymology ; Candida/metabolism ; Cell Line ; Ergosterol/antagonists & inhibitors ; Ergosterol/biosynthesis ; Female ; Humans ; Indoles/chemistry ; Mice ; Microbial Sensitivity Tests ; Species Specificity ; Triazoles/chemistry
Czasopismo naukowe
Tytuł :
Targeting the SARS-CoV-2 main protease using FDA-approved Isavuconazonium, a P2-P3 α-ketoamide derivative and Pentagastrin: An in-silico drug discovery approach.
Autorzy :
Achilonu I; Protein Structure-Function Research Unit, School of Molecular and Cell Biology, Faculty of Sciences, University of Witwatersrand, Johannesburg, 2050, South Africa. Electronic address: .
Iwuchukwu EA; Protein Structure-Function Research Unit, School of Molecular and Cell Biology, Faculty of Sciences, University of Witwatersrand, Johannesburg, 2050, South Africa.
Achilonu OJ; Division of Biostatistics, School of Public Health, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, 2050, South Africa.
Fernandes MA; Molecular Sciences Institute, School of Chemistry, University of Witwatersrand, Johannesburg, 2050, South Africa.
Sayed Y; Protein Structure-Function Research Unit, School of Molecular and Cell Biology, Faculty of Sciences, University of Witwatersrand, Johannesburg, 2050, South Africa.
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Źródło :
Journal of molecular graphics & modelling [J Mol Graph Model] 2020 Dec; Vol. 101, pp. 107730. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cysteine Endopeptidases/*chemistry
Nitriles/*pharmacology
Pentagastrin/*pharmacology
Protease Inhibitors/*pharmacology
Pyridines/*pharmacology
Triazoles/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Viral Nonstructural Proteins/*chemistry
Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Catalytic Domain ; Computer Simulation ; Cysteine Endopeptidases/metabolism ; Databases, Pharmaceutical ; Drug Approval ; Drug Discovery ; Drug Repositioning ; High-Throughput Screening Assays/methods ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Nitriles/chemistry ; Pentagastrin/chemistry ; Protease Inhibitors/chemistry ; Pyridines/chemistry ; Triazoles/chemistry ; United States ; United States Food and Drug Administration ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Aspergillus fumigatus and pan-azole resistance: who should be concerned?
Autorzy :
Wiederhold NP; Fungus Testing Laboratory, Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Verweij PE; Department of Medical Microbiology, Radboud University Medical Center, and Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands.
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Źródło :
Current opinion in infectious diseases [Curr Opin Infect Dis] 2020 Aug; Vol. 33 (4), pp. 290-297.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antifungal Agents/*pharmacology
Aspergillosis/*immunology
Aspergillus fumigatus/*immunology
Coronavirus Infections/*immunology
Drug Resistance, Multiple, Fungal/*immunology
Pneumonia, Viral/*immunology
Triazoles/*pharmacology
Antifungal Agents/therapeutic use ; Aspergillosis/drug therapy ; Aspergillosis/microbiology ; Aspergillus fumigatus/drug effects ; Betacoronavirus/immunology ; Environmental Exposure ; Humans ; Immunocompromised Host/immunology ; Microbial Sensitivity Tests ; Pandemics ; Triazoles/therapeutic use
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Comparison of the efficacy and safety of tofacitinib and filgotinib in patients with active rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials.
Autorzy :
Lee YH; Department of Rheumatology, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul, Korea (Republic of). .
Song GG; Department of Rheumatology, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul, Korea (Republic of).
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Transliterated Title :
Vergleich der Wirksamkeit und Sicherheit von Tofacitinib und Filgotinib bei Patienten mit aktiver rheumatoider Arthritis: eine Bayes-Netzwerk-Metaanalyse randomisierter kontrollierter Studien.
Źródło :
Zeitschrift fur Rheumatologie [Z Rheumatol] 2020 Aug; Vol. 79 (6), pp. 590-603.
Typ publikacji :
Journal Article; Meta-Analysis
MeSH Terms :
Antirheumatic Agents*/therapeutic use
Arthritis, Rheumatoid*/drug therapy
Piperidines/*therapeutic use
Pyridines/*therapeutic use
Pyrimidines/*therapeutic use
Pyrroles/*therapeutic use
Triazoles/*therapeutic use
Bayes Theorem ; Drug Therapy, Combination ; Humans ; Methotrexate/therapeutic use ; Network Meta-Analysis ; Piperidines/adverse effects ; Pyridines/adverse effects ; Pyrimidines/adverse effects ; Pyrroles/adverse effects ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Triazoles/adverse effects
Czasopismo naukowe
Tytuł :
Suvorexant for the prevention of delirium: A meta-analysis.
Autorzy :
Xu S; aOutpatient Department bGeneral Daycare Ward cIntensive Care Unit, Huashan Hospital Affiliated to Fudan University, Shanghai, China.
Cui Y
Shen J
Wang P
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Jul 24; Vol. 99 (30), pp. e21043.
Typ publikacji :
Journal Article; Meta-Analysis; Review
MeSH Terms :
Azepines/*therapeutic use
Delirium/*prevention & control
Sleep Aids, Pharmaceutical/*therapeutic use
Triazoles/*therapeutic use
Azepines/adverse effects ; Humans ; Length of Stay ; Mortality ; Respiration, Artificial ; Sleep Aids, Pharmaceutical/adverse effects ; Time Factors ; Triazoles/adverse effects
Czasopismo naukowe
Tytuł :
Detailed In Vitro Pharmacological Characterization of Clinically Tested Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5.
Autorzy :
Arsova A; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A., T.C.M., L.V., S.R.F., H.B.-O.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (K.J.G.); and Cardiovascular Research, Novo Nordisk A/S, Måløv, Denmark (J.L.H.).
Møller TC; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A., T.C.M., L.V., S.R.F., H.B.-O.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (K.J.G.); and Cardiovascular Research, Novo Nordisk A/S, Måløv, Denmark (J.L.H.).
Vedel L; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A., T.C.M., L.V., S.R.F., H.B.-O.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (K.J.G.); and Cardiovascular Research, Novo Nordisk A/S, Måløv, Denmark (J.L.H.).
Hansen JL; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A., T.C.M., L.V., S.R.F., H.B.-O.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (K.J.G.); and Cardiovascular Research, Novo Nordisk A/S, Måløv, Denmark (J.L.H.).
Foster SR; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A., T.C.M., L.V., S.R.F., H.B.-O.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (K.J.G.); and Cardiovascular Research, Novo Nordisk A/S, Måløv, Denmark (J.L.H.).
Gregory KJ; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A., T.C.M., L.V., S.R.F., H.B.-O.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (K.J.G.); and Cardiovascular Research, Novo Nordisk A/S, Måløv, Denmark (J.L.H.) .
Bräuner-Osborne H; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A., T.C.M., L.V., S.R.F., H.B.-O.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (K.J.G.); and Cardiovascular Research, Novo Nordisk A/S, Måløv, Denmark (J.L.H.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2020 Jul; Vol. 98 (1), pp. 49-60. Date of Electronic Publication: 2020 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Imidazoles/*pharmacology
Indoles/*pharmacology
Isoxazoles/*pharmacology
Pyridines/*pharmacology
Receptor, Metabotropic Glutamate 5/*antagonists & inhibitors
Triazoles/*pharmacology
Allosteric Regulation/drug effects ; Animals ; Calcium/metabolism ; HEK293 Cells ; Humans ; Imidazoles/chemistry ; Indoles/chemistry ; Inositol Phosphates/metabolism ; Isoxazoles/chemistry ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Molecular Structure ; Phosphorylation/drug effects ; Pyridines/chemistry ; Rats ; Time Factors ; Triazoles/chemistry
Czasopismo naukowe
Tytuł :
Comparative efficacy and safety of 100 mg and 200 mg filgotinib administered to patients with active rheumatoid arthritis: A Bayesian network meta-analysis of randomized controlled trials
.
Autorzy :
Song GG
Lee YH
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Źródło :
International journal of clinical pharmacology and therapeutics [Int J Clin Pharmacol Ther] 2020 Jun; Vol. 58 (6), pp. 293-298.
Typ publikacji :
Journal Article; Meta-Analysis
MeSH Terms :
Antirheumatic Agents/*administration & dosage
Arthritis, Rheumatoid/*drug therapy
Pyridines/*administration & dosage
Triazoles/*administration & dosage
Antirheumatic Agents/adverse effects ; Bayes Theorem ; Drug Therapy, Combination ; Humans ; Janus Kinase 1/antagonists & inhibitors ; Methotrexate/administration & dosage ; Methotrexate/adverse effects ; Network Meta-Analysis ; Pyridines/adverse effects ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Triazoles/adverse effects
Czasopismo naukowe
Tytuł :
Triazolo-Peptidomimetics: Novel Radiolabeled Minigastrin Analogs for Improved Tumor Targeting.
Autorzy :
Grob NM; Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zürich, Switzerland.
Häussinger D; Department of Chemistry, University of Basel, 4056 Basel, Switzerland.
Deupi X; Condensed Matter Theory Group, Laboratory for Scientific Computing and Modelling, Paul Scherrer Institute, 5232 Villigen, Switzerland.; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Schibli R; Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zürich, Switzerland.; Center for Radiopharmaceutical Sciences, Division of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Behe M; Center for Radiopharmaceutical Sciences, Division of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Mindt TL; Ludwig Boltzmann Institute Applied Diagnostics, General Hospital of Vienna, 1090 Vienna, Austria.; Department of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.; Department of Biomedical Imaging and Image Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 May 14; Vol. 63 (9), pp. 4484-4495. Date of Electronic Publication: 2020 Apr 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Gastrins/*pharmacology
Peptidomimetics/*pharmacology
Radiopharmaceuticals/*pharmacology
Triazoles/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacokinetics ; Cell Line, Tumor ; Female ; Gastrins/chemical synthesis ; Gastrins/metabolism ; Gastrins/pharmacokinetics ; Humans ; Lutetium/chemistry ; Mice ; Neoplasms/metabolism ; Peptidomimetics/chemical synthesis ; Peptidomimetics/metabolism ; Peptidomimetics/pharmacokinetics ; Protein Binding ; Protein Conformation ; Radioisotopes/chemistry ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/metabolism ; Radiopharmaceuticals/pharmacokinetics ; Receptor, Cholecystokinin B/metabolism ; Triazoles/chemical synthesis ; Triazoles/metabolism ; Triazoles/pharmacokinetics
Czasopismo naukowe
Tytuł :
Design of Radiolabeled Analogs of Minigastrin by Multiple Amide-to-Triazole Substitutions.
Autorzy :
Grob NM; Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zürich, Switzerland.
Schmid S; Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zürich, Switzerland.
Schibli R; Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zürich, Switzerland.; Center for Radiopharmaceutical Sciences, Division of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Behe M; Center for Radiopharmaceutical Sciences, Division of Biology and Chemistry, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Mindt TL; Ludwig Boltzmann Institute Applied Diagnostics, General Hospital of Vienna, 1090 Vienna, Austria.; Department of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.; Department of Biomedical Imaging and Image Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 May 14; Vol. 63 (9), pp. 4496-4505. Date of Electronic Publication: 2020 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Gastrins/*pharmacology
Peptidomimetics/*pharmacology
Radiopharmaceuticals/*pharmacology
Triazoles/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacokinetics ; Cell Line, Tumor ; Drug Design ; Gastrins/chemical synthesis ; Gastrins/metabolism ; Gastrins/pharmacokinetics ; Humans ; Lutetium/chemistry ; Mice ; Neoplasms/metabolism ; Peptidomimetics/chemical synthesis ; Peptidomimetics/metabolism ; Peptidomimetics/pharmacokinetics ; Protein Binding ; Radioisotopes/chemistry ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/metabolism ; Radiopharmaceuticals/pharmacokinetics ; Receptor, Cholecystokinin B/metabolism ; Triazoles/chemical synthesis ; Triazoles/metabolism ; Triazoles/pharmacokinetics
Czasopismo naukowe

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