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Tytuł :
The Positively Charged C-Terminal Region of Human Skeletal Troponin T Retards Activation and Decreases Calcium Sensitivity.
Autorzy :
Lopez Davila AJ; Institute of Molecular and Cell Physiology, Hannover Medical School, Carl-Neuberg-Street 1, 103-Block 1-Ebene 03-1010, Hannover 30625, Germany.
Zhu L; Department of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27834, United States.
Fritz L; Institute of Molecular and Cell Physiology, Hannover Medical School, Carl-Neuberg-Street 1, 103-Block 1-Ebene 03-1010, Hannover 30625, Germany.
Kraft T; Institute of Molecular and Cell Physiology, Hannover Medical School, Carl-Neuberg-Street 1, 103-Block 1-Ebene 03-1010, Hannover 30625, Germany.
Chalovich JM; Department of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27834, United States.
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Źródło :
Biochemistry [Biochemistry] 2020 Nov 03; Vol. 59 (43), pp. 4189-4201. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*pharmacology
Troponin T/*metabolism
Humans ; Kinetics ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Tropomyosin/chemistry ; Tropomyosin/metabolism ; Troponin C/chemistry ; Troponin C/metabolism ; Troponin I/chemistry ; Troponin I/metabolism ; Troponin T/chemistry
Czasopismo naukowe
Tytuł :
Eliminating the First Inactive State and Stabilizing the Active State of the Cardiac Regulatory System Alters Behavior in Solution and in Ordered Systems.
Autorzy :
Johnson D; Department of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina, United States.
Landim-Vieira M; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, United States.
Solı S C; Department of Chemistry and Biochemistry, South Dakota State University, Brookings, South Dakota 57007, United States.
Zhu L; Department of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina, United States.
Robinson JM; Department of Chemistry and Biochemistry, South Dakota State University, Brookings, South Dakota 57007, United States.
Pinto JR; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, United States.
Chalovich JM; Department of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina, United States.
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Źródło :
Biochemistry [Biochemistry] 2020 Sep 22; Vol. 59 (37), pp. 3487-3497. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Movement*
Actins/*metabolism
Calcium/*metabolism
Myocardium/*metabolism
Tropomyosin/*metabolism
Troponin C/*metabolism
Troponin T/*metabolism
Adenosine Triphosphatases/metabolism ; Animals ; Cattle ; Humans ; Myocardium/cytology ; Protein Binding ; Troponin C/chemistry ; Troponin C/genetics ; Troponin T/chemistry ; Troponin T/genetics
Czasopismo naukowe
Tytuł :
Clinically Divergent Mutation Effects on the Structure and Function of the Human Cardiac Tropomyosin Overlap.
Autorzy :
McConnell M; Department of Biomedical Engineering, University of Arizona , Tucson, Arizona 85721, United States.
Tal Grinspan L; Department of Medicine, Columbia University Medical Center , New York, New York 10032, United States.
Williams MR; Department of Chemistry and Biochemistry, University of Arizona , Tucson, Arizona 85721, United States.
Lynn ML; Department of Physiological Sciences, University of Arizona , Tucson, Arizona 85724, United States.
Schwartz BA; Graduate Interdisciplinary Program in Neuroscience, University of Arizona , Tucson, Arizona 85721, United States.
Fass OZ; Department of Physiological Sciences, University of Arizona , Tucson, Arizona 85724, United States.
Schwartz SD; Department of Chemistry and Biochemistry, University of Arizona , Tucson, Arizona 85721, United States.
Tardiff JC; Department of Biomedical Engineering, University of Arizona , Tucson, Arizona 85721, United States.; Department of Physiological Sciences, University of Arizona , Tucson, Arizona 85724, United States.; Department of Medicine, University of Arizona , Tucson, Arizona 85724, United States.
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Źródło :
Biochemistry [Biochemistry] 2017 Jul 05; Vol. 56 (26), pp. 3403-3413. Date of Electronic Publication: 2017 Jun 21.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Molecular*
Point Mutation*
Cardiomyopathy, Dilated/*genetics
Cardiomyopathy, Hypertrophic, Familial/*genetics
Sarcomeres/*metabolism
Tropomyosin/*metabolism
Troponin T/*metabolism
Adenosine Triphosphate/metabolism ; Amino Acid Substitution ; Animals ; Cardiomyopathy, Dilated/metabolism ; Cardiomyopathy, Hypertrophic, Familial/metabolism ; Computational Biology ; Humans ; Molecular Dynamics Simulation ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Protein Stability ; Rabbits ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Sarcomeres/chemistry ; Tropomyosin/chemistry ; Tropomyosin/genetics ; Troponin/chemistry ; Troponin/genetics ; Troponin/metabolism ; Troponin C/chemistry ; Troponin C/genetics ; Troponin C/metabolism ; Troponin I/chemistry ; Troponin I/genetics ; Troponin I/metabolism ; Troponin T/chemistry ; Troponin T/genetics
SCR Disease Name :
Familial dilated cardiomyopathy
Czasopismo naukowe
Tytuł :
Further Investigation into the Biochemical Effects of Phosphorylation of Tropomyosin Tpm1.1(α). Serine-283 Is in Communication with the Midregion.
Autorzy :
Silva AMM; Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland A1B 3X9, Canada.
Goonasekara CL; Department of Biochemistry, Faculty of Medicine, Kotelawala University, Colombo 10390, Sri Lanka.
Hayley M; Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland A1B 3X9, Canada.
Heeley DH; Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland A1B 3X9, Canada.
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Źródło :
Biochemistry [Biochemistry] 2020 Dec 22; Vol. 59 (50), pp. 4725-4734. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Tropomyosin/*chemistry
Actin Cytoskeleton/chemistry ; Actin Cytoskeleton/metabolism ; Actins/chemistry ; Actins/metabolism ; Adenosine Triphosphate/metabolism ; Amino Acid Sequence ; Animals ; Binding Sites ; In Vitro Techniques ; Kinetics ; Muscle, Skeletal/chemistry ; Muscle, Skeletal/metabolism ; Myocardium/chemistry ; Myocardium/metabolism ; Myosin Subfragments/chemistry ; Myosin Subfragments/metabolism ; Phosphorylation ; Protein Conformation ; Protein Stability ; Proteolysis ; Rabbits ; Rats ; Serine/chemistry ; Tropomyosin/metabolism ; Troponin/chemistry ; Troponin/metabolism
Czasopismo naukowe
Tytuł :
Characterization of the L29Q Hypertrophic Cardiomyopathy Mutation in Cardiac Troponin C by Paramagnetic Relaxation Enhancement Nuclear Magnetic Resonance.
Autorzy :
Potluri PR; Department of Molecular Sciences , Macquarie University , Sydney , NSW 2109 , Australia.
Cordina NM; Department of Molecular Sciences , Macquarie University , Sydney , NSW 2109 , Australia.
Kachooei E; Department of Molecular Sciences , Macquarie University , Sydney , NSW 2109 , Australia.
Brown LJ; Department of Molecular Sciences , Macquarie University , Sydney , NSW 2109 , Australia.
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Źródło :
Biochemistry [Biochemistry] 2019 Feb 19; Vol. 58 (7), pp. 908-917. Date of Electronic Publication: 2019 Jan 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Cardiomyopathy, Hypertrophic/*genetics
Leucine/*genetics
Troponin C/*chemistry
Troponin C/*genetics
Animals ; Calcium/metabolism ; Cysteine/chemistry ; Cysteine/genetics ; Electron Spin Resonance Spectroscopy ; Humans ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Protein Conformation ; Protein Domains ; Rats ; Spin Labels ; Troponin C/metabolism
Czasopismo naukowe
Tytuł :
Reversible Covalent Reaction of Levosimendan with Cardiac Troponin C in Vitro and in Situ.
Autorzy :
Klein BA; Department of Biochemistry, Faculty of Medicine and Dentistry , University of Alberta , Edmonton , Alberta T6G 2H7 , Canada.
Reiz B; Department of Chemistry, Faculty of Science , University of Alberta , Edmonton , Alberta T6H 2H7 , Canada.
Robertson IM; Pharmaceutical and Health Benefits Branch, Ministry of Health , Government of Alberta , Edmonton , Alberta T5J 3Z5 , Canada.
Irving M; Randall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence , King's College London , London SE1 1UL , U.K.
Li L; Department of Chemistry, Faculty of Science , University of Alberta , Edmonton , Alberta T6H 2H7 , Canada.
Sun YB; Randall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence , King's College London , London SE1 1UL , U.K.
Sykes BD; Department of Biochemistry, Faculty of Medicine and Dentistry , University of Alberta , Edmonton , Alberta T6G 2H7 , Canada.
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Źródło :
Biochemistry [Biochemistry] 2018 Apr 17; Vol. 57 (15), pp. 2256-2265. Date of Electronic Publication: 2018 Mar 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hydrazones*/chemistry
Hydrazones*/pharmacokinetics
Hydrazones*/pharmacology
Myocardial Ischemia*/metabolism
Myocardial Ischemia*/pathology
Myofibrils*/chemistry
Myofibrils*/metabolism
Myofibrils*/ultrastructure
Pyridazines*/chemistry
Pyridazines*/pharmacokinetics
Pyridazines*/pharmacology
Troponin C*/chemistry
Troponin C*/metabolism
Calcium Signaling/*drug effects
Animals ; Cysteine/metabolism ; Humans ; Hydrogen-Ion Concentration ; Simendan ; Swine
Czasopismo naukowe
Tytuł :
Troponin C Mutations Partially Stabilize the Active State of Regulated Actin and Fully Stabilize the Active State When Paired with Δ14 TnT.
Autorzy :
Baxley T; Department of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University , Greenville, North Carolina 27858, United States.
Johnson D; Department of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University , Greenville, North Carolina 27858, United States.
Pinto JR; Department of Biomedical Sciences, Florida State University College of Medicine , Tallahassee, Florida 32304, United States.
Chalovich JM; Department of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University , Greenville, North Carolina 27858, United States.
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Źródło :
Biochemistry [Biochemistry] 2017 Jun 13; Vol. 56 (23), pp. 2928-2937. Date of Electronic Publication: 2017 May 31.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Deletion*
Mutation*
Actins/*metabolism
Tropomyosin/*metabolism
Troponin C/*metabolism
Troponin T/*metabolism
Actins/chemistry ; Adenosine Triphosphate/metabolism ; Amino Acid Substitution ; Animals ; Calcium Signaling ; Cardiomyopathy, Hypertrophic/genetics ; Cardiomyopathy, Hypertrophic/metabolism ; Cattle ; Humans ; Kinetics ; Phosphorus Radioisotopes ; Protein Multimerization ; Protein Stability ; Rabbits ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Tropomyosin/chemistry ; Troponin C/chemistry ; Troponin C/genetics ; Troponin T/chemistry ; Troponin T/genetics
Czasopismo naukowe
Tytuł :
Structural Basis for Interaction of the Tandem Zinc Finger Domains of Human Muscleblind with Cognate RNA from Human Cardiac Troponin T.
Autorzy :
Park S; Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Phukan PD; Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Zeeb M; Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Martinez-Yamout MA; Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Dyson HJ; Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Wright PE; Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
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Źródło :
Biochemistry [Biochemistry] 2017 Aug 15; Vol. 56 (32), pp. 4154-4168. Date of Electronic Publication: 2017 Aug 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Nucleotide Motifs*
Troponin T*
RNA, Messenger/*chemistry
RNA-Binding Proteins/*chemistry
Humans ; Protein Binding ; Protein Domains ; RNA Splicing/physiology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Zinc Fingers
Czasopismo naukowe
Tytuł :
Functional Basis of Three New Recessive Mutations of Slow Skeletal Muscle Troponin T Found in Non-Amish TNNT1 Nemaline Myopathies.
Autorzy :
Amarasinghe C; Department of Physiology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States.
Hossain MM; Department of Physiology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States.
Jin JP; Department of Physiology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States.
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Źródło :
Biochemistry [Biochemistry] 2016 Aug 16; Vol. 55 (32), pp. 4560-7. Date of Electronic Publication: 2016 Aug 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Mutation*
Muscle, Skeletal/*metabolism
Myopathies, Nemaline/*metabolism
Troponin T/*genetics
Troponin T/*metabolism
Exons/genetics ; Humans ; Models, Molecular ; Myopathies, Nemaline/genetics ; Protein Conformation, alpha-Helical ; Protein Engineering ; Structure-Activity Relationship ; Troponin T/chemistry
Czasopismo naukowe
Tytuł :
Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation.
Autorzy :
Wang D; Department of Bioengineering, University of Washington, Seattle, Washington 98195, United States.
Robertson IM
Li MX
McCully ME
Crane ML
Luo Z
Tu AY
Daggett V
Sykes BD
Regnier M
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Źródło :
Biochemistry [Biochemistry] 2012 Jun 05; Vol. 51 (22), pp. 4473-87. Date of Electronic Publication: 2012 May 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Point Mutation*
Calcium/*metabolism
Troponin C/*genetics
Troponin C/*metabolism
Amides/chemistry ; Binding Sites ; Calorimetry ; Humans ; Molecular Dynamics Simulation ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Spectrometry, Fluorescence ; Titrimetry ; Troponin C/chemistry ; Troponin I/metabolism
Czasopismo naukowe
Tytuł :
Effect of N-Terminal Extension of Cardiac Troponin I on the Ca(2+) Regulation of ATP Binding and ADP Dissociation of Myosin II in Native Cardiac Myofibrils.
Autorzy :
Gunther LK; Department of Physics and Astronomy, Wayne State University , Detroit, Michigan 48201, United States.
Feng HZ; Department of Physiology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States.
Wei H; Department of Physiology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States.
Raupp J; Department of Physics and Astronomy, Wayne State University , Detroit, Michigan 48201, United States.
Jin JP; Department of Physiology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States.
Sakamoto T; Department of Physics and Astronomy, Wayne State University , Detroit, Michigan 48201, United States.; Department of Physiology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States.
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Źródło :
Biochemistry [Biochemistry] 2016 Mar 29; Vol. 55 (12), pp. 1887-97. Date of Electronic Publication: 2016 Mar 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Diphosphate/*metabolism
Adenosine Triphosphate/*metabolism
Calcium/*physiology
Myofibrils/*metabolism
Myosin Type II/*metabolism
Troponin I/*metabolism
Animals ; Calcium/pharmacology ; Dose-Response Relationship, Drug ; Heart Ventricles/drug effects ; Heart Ventricles/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Myofibrils/drug effects ; Protein Binding/physiology ; Troponin I/chemistry
Czasopismo naukowe
Tytuł :
Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems.
Autorzy :
Tikunova SB; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas 77204, USA.
Liu B
Swindle N
Little SC
Gomes AV
Swartz DR
Davis JP
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Źródło :
Biochemistry [Biochemistry] 2010 Mar 09; Vol. 49 (9), pp. 1975-84.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Engineering*
Calcium/*chemistry
Calcium/*metabolism
Troponin C/*chemistry
Troponin C/*genetics
Amino Acid Sequence ; Contractile Proteins/chemistry ; Contractile Proteins/metabolism ; Humans ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Protein Binding/genetics ; Protein Structure, Tertiary/genetics ; Troponin C/metabolism ; Troponin I/chemistry ; Troponin I/genetics ; Troponin I/metabolism ; Troponin T/genetics ; Troponin T/metabolism
Czasopismo naukowe
Tytuł :
1H NMR study of rabbit skeletal muscle troponin C: Mg2(+)-induced conformational change.
Autorzy :
Tsuda S; Department of Polymer Science, Faculty of Science, Hokkaido University, Sapporo, Japan.
Ogura K
Hasegawa Y
Yagi K
Hikichi K
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Źródło :
Biochemistry [Biochemistry] 1990 May 22; Vol. 29 (20), pp. 4951-8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Troponin*/metabolism
Animals ; Binding Sites ; Calcium/metabolism ; Magnesium/metabolism ; Magnesium/pharmacology ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Muscles/metabolism ; Protein Conformation/drug effects ; Rabbits ; Troponin C
Czasopismo naukowe
Tytuł :
N-Terminal Hypervariable Region of Muscle Type Isoforms of Troponin T Differentially Modulates the Affinity of Tropomyosin-Binding Site 1.
Autorzy :
Amarasinghe C; Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States.
Jin JP; Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States.
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Źródło :
Biochemistry [Biochemistry] 2015 Jun 23; Vol. 54 (24), pp. 3822-30. Date of Electronic Publication: 2015 Jun 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Models, Molecular*
Tropomyosin/*metabolism
Troponin T/*metabolism
Amino Acid Sequence ; Animals ; Binding Sites ; Chickens ; Chromatography, Affinity ; Conserved Sequence ; Kinetics ; Mice ; Peptide Fragments/chemistry ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Protein Engineering ; Protein Interaction Domains and Motifs ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Subunits/chemistry ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Rabbits ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Troponin T/chemistry ; Troponin T/genetics
Czasopismo naukowe
Tytuł :
Solution structure of the Apo C-terminal domain of the Lethocerus F1 troponin C isoform.
Autorzy :
De Nicola GF; Molecular Structure Division, National Institute for Medical Research, MRC, The Ridgeway, Mill Hill, London NW71AA, UK.
Martin S
Bullard B
Pastore A
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Źródło :
Biochemistry [Biochemistry] 2010 Mar 02; Vol. 49 (8), pp. 1719-26.
Typ publikacji :
Journal Article
MeSH Terms :
Heteroptera/*metabolism
Insect Proteins/*chemistry
Insect Proteins/*metabolism
Protein Isoforms/*chemistry
Protein Isoforms/*metabolism
Troponin C/*chemistry
Troponin C/*metabolism
Animals ; Calcium/metabolism ; Circular Dichroism ; Muscle, Skeletal/metabolism ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Troponin I/metabolism
Czasopismo naukowe
Tytuł :
Troponin T core structure and the regulatory NH2-terminal variable region.
Autorzy :
Biesiadecki BJ; Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
Chong SM
Nosek TM
Jin JP
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Źródło :
Biochemistry [Biochemistry] 2007 Feb 06; Vol. 46 (5), pp. 1368-79.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Troponin T/*chemistry
Amino Acid Sequence ; Animals ; Mice ; Mice, Transgenic ; Muscle Contraction ; Myocardial Contraction ; Protein Binding ; Protein Conformation ; Tropomyosin/metabolism ; Troponin C/metabolism ; Troponin I/metabolism ; Troponin T/metabolism ; Troponin T/physiology
Czasopismo naukowe
Tytuł :
NMR and mutagenesis studies on the phosphorylation region of human cardiac troponin I.
Autorzy :
Ward DG; School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Brewer SM
Gallon CE
Gao Y
Levine BA
Trayer IP
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Źródło :
Biochemistry [Biochemistry] 2004 May 18; Vol. 43 (19), pp. 5772-81.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutagenesis, Site-Directed*
Myocardium/*metabolism
Troponin I/*genetics
Troponin I/*metabolism
Alanine/genetics ; Arginine/genetics ; Calcium/metabolism ; Humans ; Macromolecular Substances ; Myocardium/enzymology ; Nitrogen Isotopes/metabolism ; Nuclear Magnetic Resonance, Biomolecular ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Phosphorylation ; Protein Binding/genetics ; Protein Kinase C/metabolism ; Protein Kinase C-alpha ; Protein Structure, Tertiary/genetics ; Protons ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Serine/genetics ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Troponin C/genetics ; Troponin C/metabolism
Czasopismo naukowe
Tytuł :
Phosphorylation and mutation of human cardiac troponin I deferentially destabilize the interaction of the functional regions of troponin I with troponin C.
Autorzy :
Li MX; CIHR Group in Protein Structure and Function, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7.
Wang X
Lindhout DA
Buscemi N
Van Eyk JE
Sykes BD
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Źródło :
Biochemistry [Biochemistry] 2003 Dec 16; Vol. 42 (49), pp. 14460-8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutagenesis, Site-Directed*
Myocardium/*metabolism
Troponin I/*genetics
Troponin I/*metabolism
Amino Acid Sequence ; Arginine/genetics ; Calcium/metabolism ; Cardiomyopathy, Hypertrophic, Familial/genetics ; Cardiomyopathy, Hypertrophic, Familial/metabolism ; Glycine/genetics ; Humans ; Molecular Sequence Data ; Nuclear Magnetic Resonance, Biomolecular ; Peptide Fragments/chemical synthesis ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Phosphorylation ; Protein Binding/genetics ; Protein Structure, Tertiary/genetics ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Serine/genetics ; Serine/metabolism ; Threonine/metabolism ; Troponin C/metabolism ; Troponin C/physiology ; Troponin I/chemical synthesis ; Troponin I/physiology ; Tryptophan/genetics
Czasopismo naukowe
Tytuł :
Selective deletion of the NH2-terminal variable region of cardiac troponin T in ischemia reperfusion by myofibril-associated mu-calpain cleavage.
Autorzy :
Zhang Z; Section of Molecular Cardiology, Evanston Northwestern Healthcare and Northwestern University Feinberg School of Medicine, Evanston, Illinois 60201, USA.
Biesiadecki BJ
Jin JP
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Źródło :
Biochemistry [Biochemistry] 2006 Sep 26; Vol. 45 (38), pp. 11681-94.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Processing, Post-Translational*/drug effects
Sequence Deletion*
Calpain/*metabolism
Myofibrils/*enzymology
Reperfusion Injury/*metabolism
Troponin T/*chemistry
Amino Acid Sequence ; Animals ; Calpain/antagonists & inhibitors ; Cattle ; Chickens ; In Vitro Techniques ; Mice ; Molecular Sequence Data ; Muscle Fibers, Fast-Twitch/drug effects ; Myocardium/metabolism ; Octoxynol/pharmacology ; Peptide Hydrolases/metabolism ; Rats ; Reperfusion Injury/chemically induced ; Tropomyosin/metabolism ; Troponin I/metabolism ; Troponin T/genetics
Czasopismo naukowe

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