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Tytuł :
The evolutionarily conserved C-terminal peptide of troponin I is an independently configured regulatory structure to function as a myofilament Ca -desensitizer.
Autorzy :
Wong S; Department of Physiology, Wayne State University School of Medicine, 540 E. Canfield, Detroit, MI 48201, USA.
Feng HZ; Department of Physiology, Wayne State University School of Medicine, 540 E. Canfield, Detroit, MI 48201, USA.
Jin JP; Department of Physiology, Wayne State University School of Medicine, 540 E. Canfield, Detroit, MI 48201, USA. Electronic address: .
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2019 Nov; Vol. 136, pp. 42-52. Date of Electronic Publication: 2019 Sep 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium/*metabolism
Myofibrils/*metabolism
Troponin I/*chemistry
Troponin I/*metabolism
Amino Acid Sequence ; Animals ; Conserved Sequence ; Epitopes/chemistry ; Evolution, Molecular ; Heart Ventricles/drug effects ; Humans ; Mice, Inbred C57BL ; Muscle Relaxation/genetics ; Peptide Fragments/chemistry ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Peptide Fragments/pharmacology ; Rats ; Tropomyosin/metabolism ; Troponin I/genetics ; Troponin I/immunology
Czasopismo naukowe
Tytuł :
Structures reveal details of small molecule binding to cardiac troponin.
Autorzy :
Cai F; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada.
Li MX; Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Pineda-Sanabria SE; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada.
Gelozia S; Department of Chemistry, University of Alberta, Edmonton, AB, Canada.
Lindert S; Department of Chemistry and Biochemistry, Ohio State University, Columbus, OH, USA.
West F; Department of Chemistry, University of Alberta, Edmonton, AB, Canada.
Sykes BD; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada.
Hwang PM; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada; Department of Medicine, University of Alberta, Edmonton, AB, Canada. Electronic address: .
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2016 Dec; Vol. 101, pp. 134-144. Date of Electronic Publication: 2016 Nov 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Discovery*
Models, Molecular*
Troponin/*chemistry
Troponin/*metabolism
Animals ; Binding Sites ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation ; Protein Binding ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/metabolism ; Structure-Activity Relationship ; Troponin C/chemistry ; Troponin C/metabolism ; Troponin I/chemistry ; Troponin I/metabolism
Czasopismo naukowe
Tytuł :
Longitudinal correlation of biomarkers of cardiac injury, inflammation, and coagulation to outcome in hospitalized COVID-19 patients.
Autorzy :
Li C; Division of Cardiology, Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Jiang J; Division of Cardiology, Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Wang F; Division of Cardiology, Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhou N; Division of Cardiology, Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Veronese G; 'De Gasperis' Cardio Center and Transplant Center, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore 3, 20162 Milan, Italy; University of Milan-Bicocca, School of Medicine and Surgery, Monza, Italy.
Moslehi JJ; Cardio-Oncology Program, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Ammirati E; 'De Gasperis' Cardio Center and Transplant Center, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore 3, 20162 Milan, Italy. Electronic address: .
Wang DW; Division of Cardiology, Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: .
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2020 Oct; Vol. 147, pp. 74-87. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronavirus Infections/*pathology
Cytokines/*blood
Heart Injuries/*pathology
Pneumonia, Viral/*pathology
Troponin I/*blood
Aged ; Betacoronavirus ; Biomarkers/blood ; Blood Coagulation/physiology ; COVID-19 ; Coronavirus Infections/blood ; Critical Illness ; Female ; Heart Injuries/blood ; Heart Injuries/diagnosis ; Humans ; Inflammation ; Longitudinal Studies ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/blood ; Prognosis ; Retrospective Studies ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Structural and functional impact of troponin C-mediated Ca sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle.
Autorzy :
Gonzalez-Martinez D; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.
Johnston JR; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.
Landim-Vieira M; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.
Ma W; Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL, USA.
Antipova O; Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL, USA; X-Ray Science Division, Advanced Photon Source, Argonne National Laboratory, Lemont, IL, USA.
Awan O; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.
Irving TC; Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL, USA.
Bryant Chase P; Department of Biological Science, Florida State University, Tallahassee, FL, USA.
Pinto JR; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA. Electronic address: .
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2018 Oct; Vol. 123, pp. 26-37. Date of Electronic Publication: 2018 Aug 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Myocardial Contraction*
Calcium/*metabolism
Myocardium/*metabolism
Myofibrils/*metabolism
Troponin C/*metabolism
Algorithms ; Animals ; Calcium Signaling ; Cardiomyopathy, Hypertrophic/genetics ; Cardiomyopathy, Hypertrophic/metabolism ; Cardiomyopathy, Hypertrophic/pathology ; Cardiomyopathy, Hypertrophic/physiopathology ; Disease Models, Animal ; Female ; Humans ; Isometric Contraction ; Kinetics ; Male ; Mice ; Models, Molecular ; Models, Theoretical ; Mutation ; Myocardium/chemistry ; Myofibrils/chemistry ; Protein Binding ; Protein Conformation ; Protein Interaction Domains and Motifs ; Structure-Activity Relationship ; Troponin C/chemistry ; Troponin C/genetics
Czasopismo naukowe
Tytuł :
Probing the mechanism of cardiovascular drugs using a covalent levosimendan analog.
Autorzy :
Pineda-Sanabria SE; Department of Biochemistry, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Robertson IM; Randall Division of Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, UK.
Sun YB; Randall Division of Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, UK.
Irving M; Randall Division of Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, UK.
Sykes BD; Department of Biochemistry, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB T6G 2H7, Canada. Electronic address: .
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2016 Mar; Vol. 92, pp. 174-84. Date of Electronic Publication: 2016 Feb 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cardiovascular Agents/*chemistry
Heart Failure/*drug therapy
Hydrazones/*chemistry
Pyridazines/*chemistry
Troponin C/*chemistry
Animals ; Calcium/chemistry ; Calcium/metabolism ; Cardiovascular Agents/metabolism ; Cardiovascular Agents/therapeutic use ; Heart Failure/pathology ; Humans ; Hydrazones/metabolism ; Hydrazones/therapeutic use ; Myocardial Contraction/drug effects ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Protein Conformation/drug effects ; Pyridazines/metabolism ; Pyridazines/therapeutic use ; Rats ; Simendan ; Troponin C/metabolism ; Troponin I/chemistry ; Troponin I/metabolism
Czasopismo naukowe
Tytuł :
Cardiac injuries in coronavirus disease 2019 (COVID-19).
Autorzy :
Chen C; Division of Cardiology, Department of Internal Medicine, Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: .
Li H; Division of Cardiology, Department of Internal Medicine, Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hang W; Division of Cardiology, Department of Internal Medicine, Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Wang DW; Division of Cardiology, Department of Internal Medicine, Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: .
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2020 Aug; Vol. 145, pp. 25-29. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Case Reports; Journal Article; Review
MeSH Terms :
Betacoronavirus*
Coronary Disease/*epidemiology
Coronavirus Infections/*epidemiology
Myocarditis/*epidemiology
Pneumonia, Viral/*epidemiology
Adult ; Biomarkers/blood ; COVID-19 ; Comorbidity ; Coronary Disease/virology ; Coronavirus Infections/immunology ; Coronavirus Infections/mortality ; Coronavirus Infections/virology ; Humans ; Interleukin-6/blood ; Male ; Myocarditis/drug therapy ; Myocarditis/immunology ; Myocarditis/virology ; Natriuretic Peptide, Brain/blood ; Pandemics ; Peptide Fragments/blood ; Pneumonia, Viral/immunology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/virology ; Risk Factors ; SARS-CoV-2 ; Treatment Outcome ; Troponin I/blood
Czasopismo naukowe
Tytuł :
The art of the deal in myofilament modulation of function.
Autorzy :
Westfall MV; Department of Cardiac Surgery, University of Michigan School of Medicine, NCRC Building 26, Room 263S, 2800 Plymouth Road, Ann Arbor, MI 48109, USA. Electronic address: .
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2014 Jul; Vol. 72, pp. 238-40. Date of Electronic Publication: 2014 Apr 13.
Typ publikacji :
Editorial; Research Support, N.I.H., Extramural
MeSH Terms :
Myocardial Ischemia/*metabolism
Myocytes, Cardiac/*metabolism
Myofibrils/*metabolism
Troponin I/*metabolism
Animals ; Calcium/metabolism ; Humans ; Hydrogen-Ion Concentration ; Myocardial Ischemia/physiopathology ; Myocytes, Cardiac/chemistry ; Myocytes, Cardiac/pathology ; Myofibrils/chemistry ; Myofibrils/pathology ; Phosphorylation ; Troponin C/chemistry ; Troponin C/metabolism ; Troponin I/chemistry ; Troponin T/chemistry ; Troponin T/metabolism
Raport
Tytuł :
Combined troponin I Ser-150 and Ser-23/24 phosphorylation sustains thin filament Ca(2+) sensitivity and accelerates deactivation in an acidic environment.
Autorzy :
Nixon BR; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Walton SD; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Zhang B; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Brundage EA; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Little SC; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Ziolo MT; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Davis JP; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Biesiadecki BJ; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA. Electronic address: .
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2014 Jul; Vol. 72, pp. 177-85. Date of Electronic Publication: 2014 Mar 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Protein Processing, Post-Translational*
Actin Cytoskeleton/*metabolism
Calcium/*metabolism
Heart Ventricles/*metabolism
Myocardial Infarction/*metabolism
Troponin I/*metabolism
Actins/metabolism ; Adaptation, Physiological ; Animals ; Heart Ventricles/pathology ; Humans ; Hydrogen-Ion Concentration ; Mice ; Mice, Inbred C57BL ; Myocardial Contraction ; Myocardial Infarction/pathology ; Myosins/metabolism ; Phosphorylation ; Protein Binding ; Troponin C/metabolism
Czasopismo naukowe
Tytuł :
Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity.
Autorzy :
Lin YH; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America.
Schmidt W; Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Fritz KS; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America.
Jeong MY; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America.
Cammarato A; Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Foster DB; Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Biesiadecki BJ; Department of Physiology and Cell Biology, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States of America.
McKinsey TA; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America; Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America. Electronic address: .
Woulfe KC; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America. Electronic address: .
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2020 Feb; Vol. 139, pp. 135-147. Date of Electronic Publication: 2020 Jan 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Myocardium/*metabolism
Myofibrils/*metabolism
Troponin I/*metabolism
Acetylation ; Animals ; Female ; Heart Ventricles/cytology ; Lysine/metabolism ; Myocytes, Cardiac/metabolism ; Rats, Inbred Dahl ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes.
Autorzy :
Land S; Department of Biomedical Engineering, King's College London, UK. Electronic address: .
Park-Holohan SJ; Cardiovascular Division, King's College London British Heart Foundation Centre of Research Excellence, UK.
Smith NP; Department of Engineering Science, University of Auckland, New Zealand.
Dos Remedios CG; Department of Anatomy and Histology, University of Sydney, Australia.
Kentish JC; Cardiovascular Division, King's College London British Heart Foundation Centre of Research Excellence, UK.
Niederer SA; Department of Biomedical Engineering, King's College London, UK.
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2017 May; Vol. 106, pp. 68-83. Date of Electronic Publication: 2017 Apr 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Myocytes, Cardiac/*metabolism
Troponin C/*chemistry
Humans ; Isometric Contraction/physiology ; Kinetics ; Muscle Contraction/physiology ; Myocardial Contraction/physiology ; Myocytes, Cardiac/pathology ; Sarcomeres/chemistry ; Sarcomeres/metabolism ; Troponin C/metabolism
Czasopismo naukowe
Tytuł :
The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29Q.
Autorzy :
Robertson IM; Randall Division of Cell & Molecular Biophysics, King's College London, London SE1 1UL, UK; British Heart Foundation Centre of Research Excellence, King's College London, London SE1 1UL, UK; Department of Biochemistry, Medical Sciences Building, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Sevrieva I; Randall Division of Cell & Molecular Biophysics, King's College London, London SE1 1UL, UK; British Heart Foundation Centre of Research Excellence, King's College London, London SE1 1UL, UK.
Li MX; Department of Biochemistry, Medical Sciences Building, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Irving M; Randall Division of Cell & Molecular Biophysics, King's College London, London SE1 1UL, UK; British Heart Foundation Centre of Research Excellence, King's College London, London SE1 1UL, UK.
Sun YB; Randall Division of Cell & Molecular Biophysics, King's College London, London SE1 1UL, UK; British Heart Foundation Centre of Research Excellence, King's College London, London SE1 1UL, UK. Electronic address: .
Sykes BD; Department of Biochemistry, Medical Sciences Building, University of Alberta, Edmonton, Alberta T6G 2H7, Canada. Electronic address: .
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2015 Oct; Vol. 87, pp. 257-69. Date of Electronic Publication: 2015 Sep 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Cardiomyopathy, Hypertrophic, Familial/*genetics
Myocardium/*metabolism
Troponin C/*chemistry
Troponin C/*genetics
Animals ; Cardiomyopathy, Hypertrophic, Familial/metabolism ; Cardiomyopathy, Hypertrophic, Familial/pathology ; Circular Dichroism ; Humans ; Magnetic Resonance Spectroscopy ; Mutation ; Myocardial Contraction/genetics ; Myocardium/pathology ; Myosins/genetics ; Myosins/metabolism ; Phosphorylation ; Protein Conformation ; Signal Transduction ; Structure-Activity Relationship ; Troponin C/metabolism
Czasopismo naukowe
Tytuł :
Overexpression of inducible nitric oxide synthase in the diabetic heart compromises ischemic postconditioning.
Autorzy :
Wang TT; Division of Cardiac Surgery, Heart center, The First Affiliated Hospital, Sun Yat-sen University, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, PR China; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, PR China.
Shi MM; Division of Cardiac Surgery, Heart center, The First Affiliated Hospital, Sun Yat-sen University, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, PR China; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, PR China.
Liao XL; Division of Cardiac Surgery, Heart center, The First Affiliated Hospital, Sun Yat-sen University, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, PR China.
Li YQ; Division of Cardiac Surgery, Heart center, The First Affiliated Hospital, Sun Yat-sen University, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, PR China; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, PR China.
Yuan HX; Division of Cardiac Surgery, Heart center, The First Affiliated Hospital, Sun Yat-sen University, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, PR China; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, PR China.
Li Y; Division of Cardiac Surgery, Heart center, The First Affiliated Hospital, Sun Yat-sen University, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, PR China; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, PR China.
Liu X; Division of Cardiac Surgery, Heart center, The First Affiliated Hospital, Sun Yat-sen University, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, PR China; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, PR China.
Ning DS; Division of Cardiac Surgery, Heart center, The First Affiliated Hospital, Sun Yat-sen University, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, PR China; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, PR China.
Peng YM; Division of Cardiac Surgery, Heart center, The First Affiliated Hospital, Sun Yat-sen University, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, PR China; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, PR China.
Yang F; Division of Cardiac Surgery, Heart center, The First Affiliated Hospital, Sun Yat-sen University, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, PR China; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, PR China.
Mo ZW; Division of Cardiac Surgery, Heart center, The First Affiliated Hospital, Sun Yat-sen University, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, PR China; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, PR China.
Jiang YM; Department of Extracorporeal circulation, Heart center, The First Affiliated Hospital, Sun Yat-sen University, PR China.
Xu YQ; Division of Cardiac Surgery, Heart center, The First Affiliated Hospital, Sun Yat-sen University, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, PR China.
Li H; Department of Anaesthesiology, The University of Hong Kong, Hong Kong, China.
Wang M; Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, PR China.
Ou ZJ; Division of Hypertension and Vascular Diseases, Heart Center, The First Affiliated Hospital, Sun Yat-sen University, PR China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, PR China; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, PR China. Electronic address: .
Xia Z; Department of Anaesthesiology, The University of Hong Kong, Hong Kong, China. Electronic address: .
Ou JS; Division of Cardiac Surgery, Heart center, The First Affiliated Hospital, Sun Yat-sen University, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, PR China; National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, PR China; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou 510080, PR China. Electronic address: .
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2019 Apr; Vol. 129, pp. 144-153. Date of Electronic Publication: 2019 Feb 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ischemic Postconditioning*
Diabetes Mellitus, Experimental/*enzymology
Myocardium/*enzymology
Nitric Oxide Synthase Type II/*metabolism
Animals ; Apoptosis ; Blood Glucose/metabolism ; Body Weight ; Cytokines/metabolism ; Diabetes Mellitus, Experimental/physiopathology ; Inflammation Mediators/metabolism ; MAP Kinase Signaling System ; Mice, Inbred C57BL ; Myocardial Infarction/pathology ; Myocardial Infarction/physiopathology ; Nitric Oxide/metabolism ; Superoxides/metabolism ; Troponin T/metabolism ; Tyrosine/analogs & derivatives ; Tyrosine/metabolism ; Ventricular Function
Czasopismo naukowe
Tytuł :
Myofilament Ca sensitivity correlates with left ventricular contractility during the progression of pressure overload-induced left ventricular myocardial hypertrophy in rats.
Autorzy :
Ruppert M; Heart and Vascular Center, Semmelweis University, Budapest, Hungary; Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany. Electronic address: .
Bódi B; Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Korkmaz-Icöz S; Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany.
Loganathan S; Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany.
Jiang W; Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany.
Lehmann L; Department of Cardiology, Angiology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
Oláh A; Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Barta BA; Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Sayour AA; Heart and Vascular Center, Semmelweis University, Budapest, Hungary; Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany.
Merkely B; Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Karck M; Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany.
Papp Z; Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; HAS-UD Vascular Biology and Myocardial Pathophysiology Research Group, Hungarian Academy of Sciences, Debrecen, Hungary.
Szabó G; Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany.
Radovits T; Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2019 Apr; Vol. 129, pp. 208-218. Date of Electronic Publication: 2019 Mar 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Progression*
Myocardial Contraction*
Pressure*
Ventricular Function, Left*
Calcium/*metabolism
Hypertrophy, Left Ventricular/*physiopathology
Myofibrils/*metabolism
Animals ; Arteries/physiopathology ; Biomarkers/metabolism ; Carrier Proteins/metabolism ; Diastole ; Fibrosis ; Hypertrophy, Left Ventricular/diagnostic imaging ; Male ; Phosphorylation ; Rats, Sprague-Dawley ; Systole ; Troponin I/metabolism
Czasopismo naukowe
Tytuł :
A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis.
Autorzy :
Wijnker PJ; Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: .
Li Y; Department of Pediatrics, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, USA.
Zhang P; Department of Pediatrics, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, USA.
Foster DB; Department of Pediatrics, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, USA.
dos Remedios C; Muscle Research Unit, Bosch Institute, The University of Sydney, Sydney, Australia.
Van Eyk JE; The Advanced Clinical Biosystems Research Institute, The Heart Institute, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Stienen GJ; Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands; Department of Physics and Astronomy, VU University, Amsterdam, The Netherlands.
Murphy AM; Department of Pediatrics, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, USA.
van der Velden J; Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands; ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2015 May; Vol. 82, pp. 93-103. Date of Electronic Publication: 2015 Mar 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Interaction Domains and Motifs*
Calcium/*metabolism
Calpain/*metabolism
Myocytes, Cardiac/*metabolism
Serine/*metabolism
Troponin I/*metabolism
Actins/metabolism ; Humans ; Myofibrils/metabolism ; Phosphorylation ; Protein Binding ; Proteolysis ; Sarcomeres/metabolism ; Troponin I/chemistry
Czasopismo naukowe
Tytuł :
Temperature-sensitive sarcomeric protein post-translational modifications revealed by top-down proteomics.
Autorzy :
Cai W; Molecular and Cellular Pharmacology Training Program, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Hite ZL; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Lyu B; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Wu Z; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Lin Z; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA; Human Proteomics Program, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Gregorich ZR; Molecular and Cellular Pharmacology Training Program, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Messer AE; National Heart and Lung Institute, Imperial College London, London, UK.
McIlwain SJ; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53705, USA; UW Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Marston SB; National Heart and Lung Institute, Imperial College London, London, UK.
Kohmoto T; Department of Surgery, University of Wisconsin-Madison, Madison, WI 53705, USA.
Ge Y; Molecular and Cellular Pharmacology Training Program, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Human Proteomics Program, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA. Electronic address: .
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2018 Sep; Vol. 122, pp. 11-22. Date of Electronic Publication: 2018 Jul 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Processing, Post-Translational*
Temperature*
Myocardium/*metabolism
Proteomics/*methods
Sarcomeres/*metabolism
Adaptor Proteins, Signal Transducing ; Analysis of Variance ; Chromatography, Reverse-Phase ; Cyclic AMP/analysis ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Heart Failure/metabolism ; Humans ; LIM Domain Proteins ; Myosin Light Chains/metabolism ; Phosphorylation ; Protein Isoforms/metabolism ; Proteolysis ; Specimen Handling/adverse effects ; Tandem Mass Spectrometry ; Troponin I/metabolism ; Troponin T/metabolism
Czasopismo naukowe
Tytuł :
Cardiomyopathy-causing deletion K210 in cardiac troponin T alters phosphorylation propensity of sarcomeric proteins.
Autorzy :
Sfichi-Duke L; Department of Physiology, Center for Muscle Biology, University of Kentucky, Lexington, KY 40536, USA.
Garcia-Cazarin ML
Sumandea CA
Sievert GA
Balke CW
Zhan DY
Morimoto S
Sumandea MP
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2010 May; Vol. 48 (5), pp. 934-42. Date of Electronic Publication: 2010 Jan 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cardiomyopathies/*genetics
Cardiomyopathies/*physiopathology
Sarcomeres/*metabolism
Troponin T/*genetics
Animals ; Carrier Proteins/metabolism ; Humans ; Immunoblotting ; Mice ; Mutagenesis, Site-Directed ; Myofibrils/metabolism ; Phosphorylation/genetics ; Phosphorylation/physiology ; Protein Kinase C-alpha/metabolism ; Troponin I/metabolism ; Two-Hybrid System Techniques
Czasopismo naukowe
Tytuł :
Cardiac troponin I mutations in Australian families with hypertrophic cardiomyopathy: clinical, genetic and functional consequences.
Autorzy :
Doolan A; Agnes Ginges Centre for Molecular Cardiology, Centenary Institute, Locked Bag 6, Newtown, Sydney, NSW 2042, Australia.
Tebo M
Ingles J
Nguyen L
Tsoutsman T
Lam L
Chiu C
Chung J
Weintraub RG
Semsarian C
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2005 Feb; Vol. 38 (2), pp. 387-93. Date of Electronic Publication: 2005 Jan 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cardiomyopathy, Hypertrophic/*genetics
Cardiomyopathy, Hypertrophic/*physiopathology
Mutation/*genetics
Troponin I/*genetics
Troponin I/*metabolism
Adolescent ; Adult ; Aged ; Amino Acid Sequence ; Animals ; Australia ; Cardiomyopathy, Hypertrophic/pathology ; Female ; Genetic Predisposition to Disease/genetics ; Humans ; Male ; Middle Aged ; Molecular Sequence Data ; Pedigree ; Polymorphism, Genetic/genetics ; Protein Binding ; Sequence Alignment ; Troponin C/metabolism ; Troponin I/chemistry
Czasopismo naukowe
Tytuł :
Thin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts.
Autorzy :
Feest ER; Department of Bioengineering, University of Washington, Seattle. WA 98195, USA.
Steven Korte F; Department of Bioengineering, University of Washington, Seattle. WA 98195, USA; Centers for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.
Tu AY; Department of Bioengineering, University of Washington, Seattle. WA 98195, USA.
Dai J; Department of Bioengineering, University of Washington, Seattle. WA 98195, USA.
Razumova MV; Department of Bioengineering, University of Washington, Seattle. WA 98195, USA.
Murry CE; Department of Bioengineering, University of Washington, Seattle. WA 98195, USA; Department of Pathology, University of Washington, Seattle, WA 98195, USA; Centers for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.
Regnier M; Department of Bioengineering, University of Washington, Seattle. WA 98195, USA; Centers for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA. Electronic address: .
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2014 Jul; Vol. 72, pp. 219-27. Date of Electronic Publication: 2014 Mar 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Myocardial Infarction/*metabolism
Myocardium/*metabolism
Myocytes, Cardiac/*metabolism
Myofibrils/*metabolism
Troponin C/*genetics
Action Potentials/physiology ; Adenoviridae/genetics ; Amino Acid Substitution ; Animals ; Calcium/metabolism ; Female ; Gene Expression ; Genetic Therapy ; Genetic Vectors ; Myocardial Contraction/physiology ; Myocardial Infarction/genetics ; Myocardial Infarction/pathology ; Myocardium/pathology ; Myocytes, Cardiac/pathology ; Myofibrils/genetics ; Myofibrils/pathology ; Primary Cell Culture ; Protein Engineering ; Rats ; Rats, Inbred F344 ; Transduction, Genetic ; Troponin C/metabolism ; Video Recording
Czasopismo naukowe
Tytuł :
Single amino acid substitutions define isoform-specific effects of troponin I on myofilament Ca2+ and pH sensitivity.
Autorzy :
Westfall MV; Department of Surgery, Cardiac Surgery Section, University of Michigan, 1150 W. Medical Center Drive, B560 MSRB II, Ann Arbor, MI 48109-0686, USA. />Metzger JM
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2007 Aug; Vol. 43 (2), pp. 107-18. Date of Electronic Publication: 2007 May 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Amino Acid Substitution*
Actin Cytoskeleton/*metabolism
Calcium/*metabolism
Troponin I/*metabolism
Actin Cytoskeleton/drug effects ; Animals ; Cell Membrane Permeability/drug effects ; Detergents/pharmacology ; Hydrogen-Ion Concentration ; Isometric Contraction/drug effects ; Mutant Proteins/metabolism ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/drug effects ; Peptides/metabolism ; Protein Isoforms/chemistry ; Protein Isoforms/metabolism ; Protein Structure, Secondary ; Rats ; Sarcomeres/drug effects ; Troponin I/chemistry ; Troponin T/metabolism
Czasopismo naukowe
Tytuł :
Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure.
Autorzy :
Messer AE; National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK.
Jacques AM
Marston SB
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2007 Jan; Vol. 42 (1), pp. 247-59. Date of Electronic Publication: 2006 Nov 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Heart Failure/*metabolism
Heart Failure/*physiopathology
Myocardial Contraction/*physiology
Myocardium/*metabolism
Troponin I/*metabolism
Adult ; Calcium/metabolism ; Female ; Humans ; In Vitro Techniques ; Male ; Middle Aged ; Phosphorylation ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Serine/chemistry ; Troponin I/chemistry ; Troponin T/chemistry ; Troponin T/metabolism
Czasopismo naukowe

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