Temat: "TRPC6 Cation Channel" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression.
Autorzy:: Nishiyama K; Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.; Laboratory of Prophylactic Pharmacology, Osaka Metropolitan University Graduate School of Veterinary Science, Osaka 598-8531, Japan.
Kato Y; Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Nishimura A; National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences, Okazaki 444-8787, Japan.; Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki 444-8787, Japan.; SOKENDAI (Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies), Okazaki 444-8787, Japan.
Mi X; Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Nagata R; Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.
Mori Y; Graduate School of Engineering, Kyoto University, Kyoto 615-8530, Japan.
Azuma YT; Laboratory of Prophylactic Pharmacology, Osaka Metropolitan University Graduate School of Veterinary Science, Osaka 598-8531, Japan.
Nishida M; Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.; National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences, Okazaki 444-8787, Japan.; Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki 444-8787, Japan.; SOKENDAI (Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies), Okazaki 444-8787, Japan.; Department of Physiology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 18; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 18.
Typ publikacji:: Journal Article
MeSH Terms:: Inflammatory Bowel Diseases*/drug therapy
Inflammatory Bowel Diseases*/metabolism
TRPC6 Cation Channel*/genetics
TRPC6 Cation Channel*/metabolism
Animals ; Humans ; Mice ; Colon/metabolism ; Dextran Sulfate/adverse effects ; Disease Models, Animal ; Intestines ; Mice, Inbred C57BL ; RNA, Messenger/metabolism

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Skocz do pozycji: 2.

Tytuł:: Larixyl acetate, a TRPC6 inhibitor, attenuates pressure overload‑induced heart failure in mice.
Autorzy:: Jia M; Department of Anesthesiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhengzhou, Henan 450052, P.R. China.
Liu W; Department of Cardiothoracic Surgery, Institute of Cardiothoracic Vascular Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu 210000, P.R. China.
Zhang K; Department of Cardiothoracic Surgery, Institute of Cardiothoracic Vascular Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu 210000, P.R. China.
Wang Z; Department of Cardiothoracic Surgery, Institute of Cardiothoracic Vascular Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu 210000, P.R. China.
Li R; Department of Cardiothoracic Surgery, Institute of Cardiothoracic Vascular Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu 210000, P.R. China.
Pan J; Department of Cardiothoracic Surgery, Institute of Cardiothoracic Vascular Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu 210000, P.R. China.
Yang J; Department of Anesthesiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhengzhou, Henan 450052, P.R. China.
Wang D; Department of Cardiothoracic Surgery, Institute of Cardiothoracic Vascular Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu 210000, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2024 Mar; Vol. 29 (3). Date of Electronic Publication: 2024 Jan 26.
Typ publikacji:: Journal Article
MeSH Terms:: Heart Failure*/drug therapy
Heart Failure*/etiology
Heart Failure*/metabolism
Aortic Valve Stenosis*/metabolism
Acetates*
Naphthalenes*
Mice ; Animals ; TRPC6 Cation Channel ; Myocytes, Cardiac/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Autophagy ; Hypertrophy/metabolism ; Cardiomegaly/drug therapy ; Cardiomegaly/metabolism ; Apoptosis

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Skocz do pozycji: 3.

Tytuł:: TRPV4 Channels Promote Pathological, but Not Physiological, Cardiac Remodeling through the Activation of Calcineurin/NFAT and TRPC6.
Autorzy:: Yáñez-Bisbe L; Cardiovascular Diseases Research Group, Vall d'Hebron Institut de Recerca (VHIR), Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
Moya M; Cardiovascular Diseases Research Group, Vall d'Hebron Institut de Recerca (VHIR), Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
Rodríguez-Sinovas A; Cardiovascular Diseases Research Group, Vall d'Hebron Institut de Recerca (VHIR), Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Ruiz-Meana M; Cardiovascular Diseases Research Group, Vall d'Hebron Institut de Recerca (VHIR), Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Inserte J; Cardiovascular Diseases Research Group, Vall d'Hebron Institut de Recerca (VHIR), Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Tajes M; Bio-Heart Cardiovascular Diseases Research Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Spain.
Batlle M; Institute for Biomedical Research August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Guasch E; Institute for Biomedical Research August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Cardiology Department, Hospital Clínic, 08036 Barcelona, Spain.
Mas-Stachurska A; Institute for Biomedical Research August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Cardiology Department, Hospital del Mar, 08003 Barcelona, Spain.
Miró E; Cardiovascular Diseases Research Group, Vall d'Hebron Institut de Recerca (VHIR), Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
Rivas N; Cardiovascular Diseases Research Group, Vall d'Hebron Institut de Recerca (VHIR), Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Cardiology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
Ferreira González I; Cardiovascular Diseases Research Group, Vall d'Hebron Institut de Recerca (VHIR), Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Cardiology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.; Department of Medicine, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.; Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Garcia-Elias A; Department of Clinical Research, ASCIRES-CETIR Biomedic Group, 08029 Barcelona, Spain.
Benito B; Cardiovascular Diseases Research Group, Vall d'Hebron Institut de Recerca (VHIR), Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Cardiology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.; Department of Medicine, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 26; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 26.
Typ publikacji:: Journal Article
MeSH Terms:: Calcineurin*/metabolism
Heart Failure*/metabolism
TRPV Cation Channels*/genetics
TRPV Cation Channels*/metabolism
Ventricular Remodeling*/genetics
Animals ; Mice ; Cells, Cultured ; Fibrosis ; Isoproterenol ; Mice, Transgenic ; Myocytes, Cardiac/metabolism ; NFATC Transcription Factors/genetics ; NFATC Transcription Factors/metabolism ; TRPC6 Cation Channel/genetics ; TRPC6 Cation Channel/metabolism

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Skocz do pozycji: 4.

Tytuł:: TRPC6 Deletion Enhances eNOS Expression and Reduces LPS-Induced Acute Lung Injury.
Autorzy:: Wang M; Institute of Medical Research, Northwestern Polytechnical University, Xi'an 710072, China.; Department of Pharmacy, Faculty of Medicine, Qinghai University, Xining 810001, China.
Zhang X; Department of Pharmacy, Faculty of Medicine, Qinghai University, Xining 810001, China.
Guo J; Institute of Medical Research, Northwestern Polytechnical University, Xi'an 710072, China.
Yang S; Institute of Medical Research, Northwestern Polytechnical University, Xi'an 710072, China.
Yang F; Department of Pharmacy, Faculty of Medicine, Qinghai University, Xining 810001, China.
Chen X; Institute of Medical Research, Northwestern Polytechnical University, Xi'an 710072, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 25; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 25.
Typ publikacji:: Journal Article
MeSH Terms:: Acute Lung Injury*/chemically induced
Acute Lung Injury*/genetics
Acute Lung Injury*/metabolism
Transient Receptor Potential Channels*/metabolism
Animals ; Humans ; Mice ; Edema/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Lipopolysaccharides/adverse effects ; Lung/metabolism ; TRPC6 Cation Channel/genetics ; TRPC6 Cation Channel/metabolism

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Skocz do pozycji: 5.

Tytuł:: Gain-of-function, focal segmental glomerulosclerosis Trpc6 mutation minimally affects susceptibility to renal injury in several mouse models.
Autorzy:: Brown BJ; Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
Boekell KL; Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
Stotter BR; Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Nephrology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Talbot BE; Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
Schlondorff JS; Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2022 Aug 01; Vol. 17 (8), pp. e0272313. Date of Electronic Publication: 2022 Aug 01 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:: Glomerulosclerosis, Focal Segmental*/pathology
Kidney Diseases*/pathology
Podocytes*/metabolism
TRPC6 Cation Channel*/genetics
TRPC6 Cation Channel*/metabolism
Albuminuria/pathology ; Angiotensin II/pharmacology ; Animals ; Disease Models, Animal ; Gain of Function Mutation ; Humans ; Kidney/pathology ; Mice ; Mutation

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Skocz do pozycji: 6.

Tytuł:: Trpc6 knockout protects against renal fibrosis by restraining the CN‑NFAT2 signaling pathway in T2DM mice.
Autorzy:: Sun R; Department of Pharmacology, Grade III Laboratory of National Administration of Traditional Chinese Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Han M; Department of Pharmacology, Grade III Laboratory of National Administration of Traditional Chinese Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Liu Y; Department of Pharmacology, Grade III Laboratory of National Administration of Traditional Chinese Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Su Y; Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Shi Q; Department of Pharmacology, Grade III Laboratory of National Administration of Traditional Chinese Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Huang L; Department of Pharmacology, Grade III Laboratory of National Administration of Traditional Chinese Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Kong L; Department of Pharmacology, Grade III Laboratory of National Administration of Traditional Chinese Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Li W; Department of Pharmacology, Grade III Laboratory of National Administration of Traditional Chinese Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Li W; Department of Pharmacology, Grade III Laboratory of National Administration of Traditional Chinese Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2024 Jan; Vol. 29 (1). Date of Electronic Publication: 2023 Dec 01.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetic Nephropathies*/metabolism
Diabetes Mellitus, Type 2*/complications
Mice ; Animals ; TRPC6 Cation Channel/genetics ; Calcineurin/metabolism ; TRPC Cation Channels/genetics ; TRPC Cation Channels/metabolism ; Calcium/metabolism ; Signal Transduction ; Fibrosis ; Mice, Knockout

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Skocz do pozycji: 7.

Tytuł:: A Putative Role for TRPC6 in Immune-Mediated Kidney Injury.
Autorzy:: 't Hart DC; Department of Nephrology, Radboud Research Institute for Medical Innovation, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
van der Vlag J; Department of Nephrology, Radboud Research Institute for Medical Innovation, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
Nijenhuis T; Department of Nephrology, Radboud Research Institute for Medical Innovation, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 16; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 16.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Kidney Diseases*/genetics
Kidney Diseases*/pathology
Podocytes*/pathology
Humans ; TRPC6 Cation Channel/genetics ; TRPC Cation Channels/genetics ; Kidney/pathology ; Kidney Glomerulus/pathology

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Skocz do pozycji: 8.

Tytuł:: Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior.
Autorzy:: Zernov N; Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia.
Popugaeva E; Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 21; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 21.
Typ publikacji:: Journal Article; Review
MeSH Terms:: TRPC Cation Channels*/metabolism
Neurons*/metabolism
Animals ; TRPC6 Cation Channel ; Synapses/metabolism ; Behavior, Animal ; Calcium/metabolism

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Skocz do pozycji: 9.

Tytuł:: Computer-Based Drug Design of Positive Modulators of Store-Operated Calcium Channels to Prevent Synaptic Dysfunction in Alzheimer's Disease.
Autorzy:: Hunanyan L; Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia.; Laboratory of Structural Bioinformatics, Institute of Biomedicine and Pharmacy, Russian-Armenian University, Yerevan 0051, Armenia.
Ghamaryan V; Laboratory of Structural Bioinformatics, Institute of Biomedicine and Pharmacy, Russian-Armenian University, Yerevan 0051, Armenia.
Makichyan A; Laboratory of Structural Bioinformatics, Institute of Biomedicine and Pharmacy, Russian-Armenian University, Yerevan 0051, Armenia.
Popugaeva E; Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Dec 19; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 19.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Drug Design*
Alzheimer Disease/*drug therapy
ORAI2 Protein/*metabolism
Stromal Interaction Molecule 2/*metabolism
TRPC6 Cation Channel/*metabolism
Alzheimer Disease/metabolism ; Animals ; Drug Discovery ; Humans ; ORAI2 Protein/chemistry ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Stromal Interaction Molecule 2/chemistry ; Synapses/drug effects ; Synapses/metabolism ; TRPC6 Cation Channel/chemistry

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Skocz do pozycji: 10.

Tytuł:: Novel gain-of-function mutation of TRPC6 Q134P contributes to late onset focal segmental glomerulosclerosis in a Chinese pedigree.
Autorzy:: Liu Z; Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, China.; Department of Nephrology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, China.
Zhang H; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Zhao S; Department of Physiology, Qingdao University, Qingdao, China.
Zhang Q; Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, China.
Zhang R; Department of Nephrology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, China.
Han Y; Department of Nephrology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, China.
Shao L; Department of Nephrology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, China.
Zhao X; Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, China.; Pokaż więcej
Źródło:: Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2021 Dec; Vol. 26 (12), pp. 1018-1025.
Typ publikacji:: Journal Article
MeSH Terms:: Mutation, Missense*
DNA/*genetics
Glomerulosclerosis, Focal Segmental/*genetics
TRPC6 Cation Channel/*genetics
Adolescent ; Adult ; Biopsy ; Cells, Cultured ; Child ; China/epidemiology ; DNA Mutational Analysis ; Female ; Glomerulosclerosis, Focal Segmental/epidemiology ; Glomerulosclerosis, Focal Segmental/pathology ; Humans ; Incidence ; Male ; Middle Aged ; Phenotype ; TRPC6 Cation Channel/metabolism ; Young Adult

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Skocz do pozycji: 11.

Tytuł:: Tacrolimus Protects Podocytes from Apoptosis via Downregulation of TRPC6 in Diabetic Nephropathy.
Autorzy:: Ma R; Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Wang Y; Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Xu Y; Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Wang R; Department of Intensive Care Unit, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Wang X; Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yu N; Department of Ultrasound, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Li M; Department of Emergency, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Zhou Y; Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.; Pokaż więcej
Źródło:: Journal of diabetes research [J Diabetes Res] 2021 May 20; Vol. 2021, pp. 8832114. Date of Electronic Publication: 2021 May 20 (Print Publication: 2021).
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis/*drug effects
Diabetic Nephropathies/*drug therapy
Podocytes/*drug effects
TRPC Cation Channels/*metabolism
TRPC6 Cation Channel/*metabolism
Tacrolimus/*pharmacology
Animals ; Apoptosis Regulatory Proteins/metabolism ; Cell Line ; Diabetic Nephropathies/genetics ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Disease Models, Animal ; Down-Regulation ; Male ; Mice ; Podocytes/metabolism ; Podocytes/ultrastructure ; Rats, Wistar ; Signal Transduction ; TRPC Cation Channels/genetics ; TRPC6 Cation Channel/genetics ; Rats

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Skocz do pozycji: 12.

Tytuł:: The lncRNA TUG1 promotes cell growth and migration in colorectal cancer via the TUG1-miR-145-5p-TRPC6 pathway.
Autorzy:: Wang X; Lanzhou University Second Hospital; Lanzhou University Second Clinical Medical College, China.
Bai X; Lanzhou University Second Hospital; Lanzhou University Second Clinical Medical College, China.
Yan Z; Lanzhou University Second Hospital; Lanzhou University Second Clinical Medical College, China.
Guo X; Lanzhou University Second Hospital; Lanzhou University Second Clinical Medical College, China.
Zhang Y; Department of General Surgery, Lanzhou University Second Hospital; Lanzhou University Second Clinical Medical College, Lanzhou, Gansu, China.; Pokaż więcej
Źródło:: Biochemistry and cell biology = Biochimie et biologie cellulaire [Biochem Cell Biol] 2021 Apr; Vol. 99 (2), pp. 249-260. Date of Electronic Publication: 2020 Sep 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Colorectal Neoplasms/*metabolism
MicroRNAs/*metabolism
RNA, Long Noncoding/*metabolism
TRPC6 Cation Channel/*metabolism
Cell Movement ; Cell Proliferation ; Cell Survival ; Cells, Cultured ; Colorectal Neoplasms/pathology ; Humans ; MicroRNAs/genetics ; RNA, Long Noncoding/genetics ; TRPC6 Cation Channel/genetics

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Skocz do pozycji: 13.

Tytuł:: Novel Mechanistic Insights and Potential Therapeutic Impact of TRPC6 in Neurovascular Coupling and Ischemic Stroke.
Autorzy:: Shekhar S; Department of Neurology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Liu Y; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Wang S; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Zhang H; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Fang X; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Zhang J; School of Medicine, I.M. Sechenov First Moscow State Medical University, Moscow 119048, Russia.
Fan L; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Zheng B; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Roman RJ; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Wang Z; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Fan F; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Booz GW; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Feb 19; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 19.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Neurovascular Coupling*
Ischemic Stroke/*physiopathology
Ischemic Stroke/*therapy
TRPC6 Cation Channel/*metabolism
Animals ; Humans ; Models, Biological ; Neurons/metabolism ; TRPC6 Cation Channel/chemistry

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Skocz do pozycji: 14.

Tytuł:: Reorganization and Suppression of Store-Operated Calcium Entry in Podocytes of Type 2 Diabetic Rats.
Autorzy:: Gusev K; Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Shalygin A; Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Kolesnikov D; Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Shuyskiy L; Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Makeenok S; Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Glushankova L; Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Sivak K; Smorodintsev Research Institute of Influenza WHO National Influenza Centre of Russia, St. Petersburg 197376, Russia.
Yakovlev K; Smorodintsev Research Institute of Influenza WHO National Influenza Centre of Russia, St. Petersburg 197376, Russia.
Orshanskaya Y; Smorodintsev Research Institute of Influenza WHO National Influenza Centre of Russia, St. Petersburg 197376, Russia.
Wang G; Department of Pharmacology, College of Pharmaceutic Sciences, Soochow University, Suzhou 215031, China.
Bakhtyukov A; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia.
Derkach K; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia.
Shpakov A; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia.
Kaznacheyeva E; Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Apr 14; Vol. 24 (8). Date of Electronic Publication: 2023 Apr 14.
Typ publikacji:: Journal Article
MeSH Terms:: Podocytes*/metabolism
Diabetic Nephropathies*/metabolism
Diabetes Mellitus, Type 2*/metabolism
Diabetes Mellitus, Experimental*/metabolism
Humans ; Rats ; Male ; Animals ; TRPC6 Cation Channel/metabolism ; Calcium Channels/metabolism ; Calcium/metabolism ; TRPC Cation Channels/metabolism

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Skocz do pozycji: 15.

Tytuł:: Potential Drug Candidates to Treat TRPC6 Channel Deficiencies in the Pathophysiology of Alzheimer's Disease and Brain Ischemia.
Autorzy:: Prikhodko V; Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia.; Department of Pharmacology and Clinical Pharmacology, Saint Petersburg State Chemical Pharmaceutical University, 197022 St. Petersburg, Russia.; N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences, 197376 St. Petersburg, Russia.
Chernyuk D; Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia.
Sysoev Y; Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia.; Department of Pharmacology and Clinical Pharmacology, Saint Petersburg State Chemical Pharmaceutical University, 197022 St. Petersburg, Russia.; N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences, 197376 St. Petersburg, Russia.; Institute of Translational Biomedicine, Saint Petersburg State University, 199034 St. Petersburg, Russia.
Zernov N; Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia.
Okovityi S; Department of Pharmacology and Clinical Pharmacology, Saint Petersburg State Chemical Pharmaceutical University, 197022 St. Petersburg, Russia.; N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences, 197376 St. Petersburg, Russia.
Popugaeva E; Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia.; Pokaż więcej
Źródło:: Cells [Cells] 2020 Oct 24; Vol. 9 (11). Date of Electronic Publication: 2020 Oct 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Alzheimer Disease/*etiology
Alzheimer Disease/*metabolism
Brain Ischemia/*etiology
Brain Ischemia/*metabolism
TRPC6 Cation Channel/*deficiency
Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Animals ; Brain Ischemia/drug therapy ; Brain Ischemia/pathology ; Disease Management ; Disease Susceptibility ; Drug Discovery ; Gene Expression Regulation/drug effects ; Humans ; Molecular Targeted Therapy ; Risk Factors ; Signal Transduction/drug effects ; TRPC6 Cation Channel/antagonists & inhibitors ; TRPC6 Cation Channel/genetics ; TRPC6 Cation Channel/metabolism

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Skocz do pozycji: 16.

Tytuł:: Acid Sphingomyelinase Impacts Canonical Transient Receptor Potential Channels 6 (TRPC6) Activity in Primary Neuronal Systems.
Autorzy:: Zeitler S; Department of Psychiatry and Psychotherapy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Schumacher F; Department of Toxicology, University of Potsdam, 14558 Nuthetal, Germany.; Institute of Pharmacy, Department of Pharmacology & Toxicology, Freie Universität Berlin, 14195 Berlin, Germany.; Institute of Molecular Biology, University of Duisburg-Essen, 45147 Essen, Germany.
Monti J; Department of Psychiatry and Psychotherapy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Anni D; Department of Psychiatry and Psychotherapy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Guhathakurta D; Department of Psychiatry and Psychotherapy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Kleuser B; Institute of Pharmacy, Department of Pharmacology & Toxicology, Freie Universität Berlin, 14195 Berlin, Germany.
Friedland K; Institute for Pharmacy and Biochemistry, Johannes-Gutenberg Universität Mainz, 55128 Mainz, Germany.
Fejtová A; Department of Psychiatry and Psychotherapy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Kornhuber J; Department of Psychiatry and Psychotherapy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Rhein C; Department of Psychiatry and Psychotherapy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.; Department of Psychosomatic Medicine and Psychotherapy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2020 Nov 18; Vol. 9 (11). Date of Electronic Publication: 2020 Nov 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Depressive Disorder, Major*/blood
Depressive Disorder, Major*/pathology
Neurons*/metabolism
Sphingomyelin Phosphodiesterase*/adverse effects
TRPC6 Cation Channel*/metabolism
Animals ; Rats ; Mice

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Skocz do pozycji: 17.

Tytuł:: Metformin prevents hypoxia-induced podocyte injury by regulating the ZEB2/TG2 axis.
Autorzy:: Kolligundla LP; Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Kavvuri R; Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Singh AK; Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Mukhi D; Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Pasupulati AK; Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.; Pokaż więcej
Źródło:: Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2023 Jan; Vol. 28 (1), pp. 60-71. Date of Electronic Publication: 2022 Oct 17.
Typ publikacji:: Journal Article
MeSH Terms:: Podocytes*/metabolism
Metformin*/pharmacology
Renal Insufficiency, Chronic*/genetics
Renal Insufficiency, Chronic*/prevention & control
Renal Insufficiency, Chronic*/metabolism
Mice ; Animals ; TRPC6 Cation Channel/genetics ; TRPC6 Cation Channel/metabolism ; Protein Glutamine gamma Glutamyltransferase 2 ; TRPC Cation Channels/genetics ; TRPC Cation Channels/metabolism ; Hypoxia/complications ; Hypoxia/metabolism ; Hypoxia/pathology

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Tytuł:: Transient receptor potential canonical 6 knockdown ameliorated diabetic kidney disease by inhibiting nuclear factor of activated T cells 2 expression in glomerular mesangial cells.
Autorzy:: Yu J; Cell Electrophysiology Laboratory, Wannan Medical College, Wuhu, China.
Li C; Cell Electrophysiology Laboratory, Wannan Medical College, Wuhu, China.
Ma L; Cell Electrophysiology Laboratory, Wannan Medical College, Wuhu, China.
Zhai B; Cell Electrophysiology Laboratory, Wannan Medical College, Wuhu, China.
Xu A; Cell Electrophysiology Laboratory, Wannan Medical College, Wuhu, China.
Shao D; Cell Electrophysiology Laboratory, Wannan Medical College, Wuhu, China.; Pokaż więcej
Źródło:: Renal failure [Ren Fail] 2022 Dec; Vol. 44 (1), pp. 1780-1790.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetic Nephropathies*/genetics
Diabetic Nephropathies*/metabolism
Diabetes Mellitus, Experimental*/metabolism
Rats ; Animals ; Mesangial Cells ; Fibronectins/metabolism ; TRPC6 Cation Channel/genetics ; TRPC6 Cation Channel/metabolism ; RNA, Small Interfering/metabolism ; Streptozocin ; Hematoxylin/metabolism ; Hematoxylin/pharmacology ; Eosine Yellowish-(YS)/metabolism ; Eosine Yellowish-(YS)/pharmacology ; T-Lymphocytes ; Glucose/metabolism ; RNA, Messenger/metabolism ; Collagen/metabolism ; Cells, Cultured

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Skocz do pozycji: 19.

Tytuł:: Capsazepine (CPZ) Inhibits TRPC6 Conductance and Is Protective in Adriamycin-Induced Nephropathy and Diabetic Glomerulopathy.
Autorzy:: Hagmann H; Department II of Internal Medicine, University Hospital Cologne, Faculty of Medicine, University of Cologne, 50937 Cologne, Germany.; Center for Molecular Medicine Cologne, University Hospital Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany.
Khayyat NH; Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Matin M; Department II of Internal Medicine, University Hospital Cologne, Faculty of Medicine, University of Cologne, 50937 Cologne, Germany.; Center for Molecular Medicine Cologne, University Hospital Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany.
Oezel C; Department II of Internal Medicine, University Hospital Cologne, Faculty of Medicine, University of Cologne, 50937 Cologne, Germany.; Center for Molecular Medicine Cologne, University Hospital Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany.
Chen H; Department II of Internal Medicine, University Hospital Cologne, Faculty of Medicine, University of Cologne, 50937 Cologne, Germany.; Center for Molecular Medicine Cologne, University Hospital Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany.
Schauss A; Cologne Cluster of Excellence on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), 50931 Cologne, Germany.
Schell C; Institute of Surgical Pathology, Faculty of Medicine, University Medical Center Freiburg, 79106 Freiburg, Germany.
Benzing T; Department II of Internal Medicine, University Hospital Cologne, Faculty of Medicine, University of Cologne, 50937 Cologne, Germany.; Center for Molecular Medicine Cologne, University Hospital Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany.; Cologne Cluster of Excellence on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), 50931 Cologne, Germany.; Systems Biology of Ageing Cologne (Sybacol), 50931 Cologne, Germany.
Dryer S; Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.; Department of Biomedical Sciences, Tilman J. Fertitta Family College of Medicine, University of Houston, Houston, TX 77204, USA.
Brinkkoetter PT; Department II of Internal Medicine, University Hospital Cologne, Faculty of Medicine, University of Cologne, 50937 Cologne, Germany.; Center for Molecular Medicine Cologne, University Hospital Cologne, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2023 Jan 10; Vol. 12 (2). Date of Electronic Publication: 2023 Jan 10.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Diabetic Nephropathies*/metabolism
Transient Receptor Potential Channels*
Diabetes Mellitus*
Mice ; Animals ; TRPC6 Cation Channel ; TRPC Cation Channels/metabolism ; Doxorubicin/adverse effects ; Mice, Knockout ; Capsaicin

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Skocz do pozycji: 20.

Tytuł:: Hyperforin Elicits Cytostatic/Cytotoxic Activity in Human Melanoma Cell Lines, Inhibiting Pro-Survival NF-κB, STAT3, AP1 Transcription Factors and the Expression of Functional Proteins Involved in Mitochondrial and Cytosolic Metabolism.
Autorzy:: Cardile A; Section of Biochemistry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Strada Le Grazie, 8, 37134 Verona, Italy.
Zanrè V; Section of Biochemistry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Strada Le Grazie, 8, 37134 Verona, Italy.
Campagnari R; Section of Biochemistry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Strada Le Grazie, 8, 37134 Verona, Italy.
Asson F; Section of Biochemistry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Strada Le Grazie, 8, 37134 Verona, Italy.
Addo SS; Section of Biochemistry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Strada Le Grazie, 8, 37134 Verona, Italy.
Orlandi E; Section of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Strada Le Grazie, 8, 37134 Verona, Italy.
Menegazzi M; Section of Biochemistry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Strada Le Grazie, 8, 37134 Verona, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jan 09; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 09.
Typ publikacji:: Journal Article
MeSH Terms:: Cytostatic Agents*/pharmacology
Melanoma*/drug therapy
Melanoma*/genetics
Melanoma*/metabolism
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Humans ; NF-kappa B/metabolism ; Proto-Oncogene Proteins B-raf/metabolism ; TRPC6 Cation Channel ; Cell Line ; Apoptosis ; Mitochondria/metabolism ; Cell Line, Tumor ; STAT3 Transcription Factor/metabolism

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