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Starter badań:

Tytuł:
Pancancer Analysis of Revealed TDO2 as a Biomarker of Prognosis and Immunotherapy.
Autorzy:
Cui J; Department of Oral and Maxillofacial Surgery, Jinan Stamotological Hospital, Jinan, 101 Jinglv Road, Shandong 250001, China.; Central Laboratory of Jinan Stamotological Hospital, Jinan Key Laboratory of Oral Tissue Regeneration, Jinan, 101 Jinglv Road, Shandong 250001, China.
Tian Y; Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Weiqi Road, Jinan, Shandong 250021, China.
Liu T; Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Weiqi Road, Jinan, Shandong 250021, China.
Lin X; Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Weiqi Road, Jinan, Shandong 250021, China.
Li L; Department of Gynecology, Central Hospital Affiliated to Shandong First Medical University, 105.jiefang road, Jinan, Shandong 250013, China.
Li Z; Department of Gynecology, Meihekou City Central Hospital, 2688 Kangmei Avenue, Meihekou city, Jilin 135000, China.
Shen L; Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Weiqi Road, Jinan, Shandong 250021, China.
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Źródło:
Disease markers [Dis Markers] 2022 Sep 09; Vol. 2022, pp. 5447017. Date of Electronic Publication: 2022 Sep 09 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Neoplasms*/genetics
Neoplasms*/therapy
Tryptophan Oxygenase*/genetics
Tryptophan Oxygenase*/metabolism
B7 Antigens/genetics ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; DNA ; Humans ; Immunotherapy ; Kynurenine/genetics ; Kynurenine/metabolism ; Methyltransferases/genetics ; Microsatellite Instability ; Prognosis ; Tryptophan/genetics ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł:
Tryptophan degradation enzymes and Angiotensin (1-7) expression in human placenta.
Autorzy:
Silvano A; Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy.
Seravalli V; Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy.
Strambi N; Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy.
Tartarotti E; Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy.
Tofani L; Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy.
Calosi L; Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, Florence, Italy.
Parenti A; Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, Italy. Electronic address: .
Di Tommaso M; Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy. Electronic address: .
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Źródło:
Journal of reproductive immunology [J Reprod Immunol] 2022 Sep; Vol. 153, pp. 103692. Date of Electronic Publication: 2022 Aug 06.
Typ publikacji:
Journal Article; Observational Study
MeSH Terms:
Kynurenine*/metabolism
Tryptophan Oxygenase*/genetics
Tryptophan Oxygenase*/metabolism
Angiotensin I ; Angiotensin II ; Female ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Infant, Newborn ; Peptide Fragments ; Placenta/metabolism ; Pregnancy ; RNA, Messenger ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł:
Targeting Indoleamine Dioxygenase and Tryptophan Dioxygenase in Cancer Immunotherapy: Clinical Progress and Challenges.
Autorzy:
Peng X; Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, People's Republic of China.
Zhao Z; Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, People's Republic of China.
Liu L; Department of Obstetrics and Gynecology, Fengrun District People's Hospital, Tangshan, Hebei, 063000, People's Republic of China.
Bai L; Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, People's Republic of China.
Tong R; Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, People's Republic of China.
Yang H; POWERCHINA Chengdu Engineering Corporation Limited, Chengdu, Sichuan, 610072, People's Republic of China.
Zhong L; Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, People's Republic of China.
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Źródło:
Drug design, development and therapy [Drug Des Devel Ther] 2022 Aug 08; Vol. 16, pp. 2639-2657. Date of Electronic Publication: 2022 Aug 08 (Print Publication: 2022).
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neoplasms*/drug therapy
Tryptophan*
Humans ; Immunotherapy ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Tryptophan Oxygenase/metabolism ; Tumor Microenvironment
Czasopismo naukowe
Tytuł:
The role of tryptophan in Chlamydia trachomatis persistence.
Autorzy:
Wang L; The First School of Clinical Medicine, Chenzhou No.1 People's Hospital, Southern Medical University, Guangzhou, China.; Department of Clinical Microbiology Laboratory, Chenzhou No.1 People's Hospital, Chenzhou, China.
Hou Y; The First School of Clinical Medicine, Chenzhou No.1 People's Hospital, Southern Medical University, Guangzhou, China.; Department of Clinical Microbiology Laboratory, Chenzhou No.1 People's Hospital, Chenzhou, China.
Yuan H; The First School of Clinical Medicine, Chenzhou No.1 People's Hospital, Southern Medical University, Guangzhou, China.; Department of Clinical Microbiology Laboratory, Chenzhou No.1 People's Hospital, Chenzhou, China.
Chen H; The First School of Clinical Medicine, Chenzhou No.1 People's Hospital, Southern Medical University, Guangzhou, China.; Department of Clinical Microbiology Laboratory, Chenzhou No.1 People's Hospital, Chenzhou, China.
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Źródło:
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Aug 02; Vol. 12, pp. 931653. Date of Electronic Publication: 2022 Aug 02 (Print Publication: 2022).
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Chlamydia Infections*/microbiology
Tryptophan Synthase*/genetics
Chlamydia trachomatis ; Humans ; Indoles/metabolism ; Interferon-gamma/metabolism ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł:
Coordination of plant growth and abiotic stress responses by tryptophan synthase β subunit 1 through modulation of tryptophan and ABA homeostasis in Arabidopsis.
Autorzy:
Liu WC; State Key Laboratory of Hybrid Rice, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China; State Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng 475004, China.
Song RF; State Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng 475004, China.
Zheng SQ; State Key Laboratory of Hybrid Rice, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China.
Li TT; State Key Laboratory of Hybrid Rice, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China.
Zhang BL; State Key Laboratory of Hybrid Rice, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China.
Gao X; State Key Laboratory of Hybrid Rice, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China.
Lu YT; State Key Laboratory of Hybrid Rice, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430072, China. Electronic address: .
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Źródło:
Molecular plant [Mol Plant] 2022 Jun 06; Vol. 15 (6), pp. 973-990. Date of Electronic Publication: 2022 Apr 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arabidopsis*/metabolism
Arabidopsis Proteins*/genetics
Arabidopsis Proteins*/metabolism
Tryptophan Synthase*/genetics
Tryptophan Synthase*/metabolism
Abscisic Acid/metabolism ; Droughts ; Gene Expression Regulation, Plant ; Homeostasis ; Hormones/metabolism ; Hydrogen Peroxide/metabolism ; Indoleacetic Acids/metabolism ; Plants, Genetically Modified/metabolism ; Stress, Physiological/genetics ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł:
Structural and biochemical basis for the substrate specificity of Pad-1, an indole-3-pyruvic acid aminotransferase in auxin homeostasis.
Autorzy:
Choi M; Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.
Rhee S; Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea; Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea. Electronic address: .
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Źródło:
Journal of structural biology [J Struct Biol] 2022 Jun; Vol. 214 (2), pp. 107857. Date of Electronic Publication: 2022 Apr 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Transaminases*/genetics
Transaminases*/metabolism
Tryptophan*
Glutamine ; Homeostasis/physiology ; Indoleacetic Acids/chemistry ; Indoles ; Kinetics ; Substrate Specificity ; Tryptophan Transaminase/metabolism
Czasopismo naukowe
Tytuł:
Impact of IDO1 and IDO2 on the B Cell Immune Response.
Autorzy:
Merlo LMF; Lankenau Institute for Medical Research, Wynnewood, PA, United States.
Peng W; Lankenau Institute for Medical Research, Wynnewood, PA, United States.
Mandik-Nayak L; Lankenau Institute for Medical Research, Wynnewood, PA, United States.
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Źródło:
Frontiers in immunology [Front Immunol] 2022 Apr 13; Vol. 13, pp. 886225. Date of Electronic Publication: 2022 Apr 13 (Print Publication: 2022).
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Indoleamine-Pyrrole 2,3,-Dioxygenase*
Tryptophan Oxygenase*
Immunity ; Tryptophan/pharmacology
Czasopismo naukowe
Tytuł:
Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.
Autorzy:
Pataskar A; Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Champagne J; Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Nagel R; Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Kenski J; Division of Molecular Oncology and Immunology, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Laos M; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Michaux J; Lausanne Branch, Ludwig Institute for Cancer Research, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; Center of Experimental Therapeutics, Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Pak HS; Lausanne Branch, Ludwig Institute for Cancer Research, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; Center of Experimental Therapeutics, Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Bleijerveld OB; NKI Proteomics facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Mordente K; Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Navarro JM; Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Blommaert N; Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Nielsen MM; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Lovecchio D; Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Stone E; Department of Molecular Biosciences, University of Texas, Austin, TX, USA.
Georgiou G; Department of Molecular Biosciences, University of Texas, Austin, TX, USA.
de Gooijer MC; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
van Tellingen O; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Altelaar M; NKI Proteomics facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht Institute for Pharmaceutical Sciences, Utrecht University and Netherlands Proteomics Centre, Utrecht, The Netherlands.
Joosten RP; Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Perrakis A; Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Olweus J; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Bassani-Sternberg M; Lausanne Branch, Ludwig Institute for Cancer Research, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.; Center of Experimental Therapeutics, Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Peeper DS; Division of Molecular Oncology and Immunology, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Agami R; Division of Oncogenomics, Oncode institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands. .; Erasmus MC, Department of Genetics, Rotterdam University, Rotterdam, The Netherlands. .
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Źródło:
Nature [Nature] 2022 Mar; Vol. 603 (7902), pp. 721-727. Date of Electronic Publication: 2022 Mar 09.
Typ publikacji:
Journal Article
MeSH Terms:
Tryptophan*/metabolism
Tryptophan-tRNA Ligase*/genetics
Tryptophan-tRNA Ligase*/metabolism
Codon/metabolism ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Interferon-gamma ; Neoplasms/immunology ; Phenylalanine ; T-Lymphocytes ; Tryptophan Oxygenase/genetics ; Tryptophan Oxygenase/metabolism
Czasopismo naukowe
Tytuł:
Construction of cell factory capable of efficiently converting L-tryptophan into 5-hydroxytryptamine.
Autorzy:
Wang Y; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Chen X; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Chen Q; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Zhou N; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Wang X; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Zhang A; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Chen K; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China. .; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China. .
Ouyang P; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
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Źródło:
Microbial cell factories [Microb Cell Fact] 2022 Mar 24; Vol. 21 (1), pp. 47. Date of Electronic Publication: 2022 Mar 24.
Typ publikacji:
Journal Article
MeSH Terms:
Serotonin*/metabolism
Tryptophan*/metabolism
5-Hydroxytryptophan/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Tryptophan Hydroxylase/genetics ; Tryptophan Hydroxylase/metabolism
Czasopismo naukowe
Tytuł:
Effect of process parameters and surfactant additives on the obtained activity of recombinant tryptophan hydroxylase (TPH1) for enzymatic synthesis of 5-hydroxytryptophan (5-HTP).
Autorzy:
Vargas MA; Laboratorio de Tecnología Enzimática para Bioprocesos, Departamento de Ingeniería en Alimentos, Universidad de La Serena, Chile.
Deive FJ; Departamento de Ingeniería Química, Campus As Lagoas-Marcosende, Universidade de Vigo, Vigo, Spain; CINTECX - Universidad de Vigo, Campus As Lagoas-Marcosende, Vigo, Spain.
Álvarez MS; Departamento de Ingeniería Química, Campus As Lagoas-Marcosende, Universidade de Vigo, Vigo, Spain; CINTECX - Universidad de Vigo, Campus As Lagoas-Marcosende, Vigo, Spain.
Longo MA; Departamento de Ingeniería Química, Campus As Lagoas-Marcosende, Universidade de Vigo, Vigo, Spain; CINTECX - Universidad de Vigo, Campus As Lagoas-Marcosende, Vigo, Spain.
Rodríguez A; Departamento de Ingeniería Química, Campus As Lagoas-Marcosende, Universidade de Vigo, Vigo, Spain.
Bernal C; Laboratorio de Tecnología Enzimática para Bioprocesos, Departamento de Ingeniería en Alimentos, Universidad de La Serena, Chile; Instituto de Investigación Multidisciplinario en Ciencia y Tecnología, Universidad de La Serena, Benavente 980, 1720010 La Serena, Chile.
Martínez R; Laboratorio de Tecnología Enzimática para Bioprocesos, Departamento de Ingeniería en Alimentos, Universidad de La Serena, Chile. Electronic address: .
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Źródło:
Enzyme and microbial technology [Enzyme Microb Technol] 2022 Mar; Vol. 154, pp. 109975. Date of Electronic Publication: 2021 Dec 18.
Typ publikacji:
Journal Article
MeSH Terms:
5-Hydroxytryptophan*
Tryptophan Hydroxylase*/genetics
Humans ; Serotonin ; Surface-Active Agents ; Tryptophan
Czasopismo naukowe
Tytuł:
Indoleamine dioxygenase and tryptophan dioxygenase activities are regulated through GAPDH- and Hsp90-dependent control of their heme levels.
Autorzy:
Biswas P; Department of Inflammation and Immunity, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH, USA.
Dai Y; Department of Inflammation and Immunity, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH, USA.
Stuehr DJ; Department of Inflammation and Immunity, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH, USA. Electronic address: .
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Źródło:
Free radical biology & medicine [Free Radic Biol Med] 2022 Feb 20; Vol. 180, pp. 179-190. Date of Electronic Publication: 2022 Jan 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Heme*
Tryptophan*/metabolism
Enzyme Inhibitors ; HEK293 Cells ; HeLa Cells ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Tryptophan Oxygenase/genetics ; Tryptophan Oxygenase/metabolism
Czasopismo naukowe
Tytuł:
A comprehensive analysis of TDO2 expression in immune cells and characterization of immune cell phenotype in TDO2 knockout mice.
Autorzy:
Li S; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Li S; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Zhao Y; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Zhang B; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Wang X; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Yang X; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Wang Y; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Jia C; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Chang Y; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China. .
Wei W; Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China. .
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Źródło:
Transgenic research [Transgenic Res] 2021 Dec; Vol. 30 (6), pp. 781-797. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Kynurenine*/genetics
Kynurenine*/metabolism
Tryptophan Oxygenase*/genetics
Tryptophan Oxygenase*/metabolism
Animals ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Mice ; Mice, Inbred DBA ; Mice, Knockout ; Phenotype ; Tryptophan/genetics ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł:
Directed Evolution Improves the Enzymatic Synthesis of L-5-Hydroxytryptophan by an Engineered Tryptophan Synthase.
Autorzy:
Xu L; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China. .
Li T; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China.
Huo Z; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China.
Chen Q; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China.
Xia Q; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China.
Jiang B; School of Biological and Food Engineering, Suzhou University, Suzhou, 234000, China.
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Źródło:
Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2021 Oct; Vol. 193 (10), pp. 3407-3417. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji:
Journal Article
MeSH Terms:
Tryptophan Synthase*
5-Hydroxytryptophan ; Escherichia coli ; Tryptophan
Czasopismo naukowe
Tytuł:
MiR-126-5p Promotes Tumor Cell Proliferation, Metastasis and Invasion by Targeting TDO2 in Hepatocellular Carcinoma.
Autorzy:
Ai Y; The State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 299 BaYi Road, Wuhan 430065, China.
Luo S; The State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 299 BaYi Road, Wuhan 430065, China.
Wang B; The State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 299 BaYi Road, Wuhan 430065, China.
Xiao S; The State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 299 BaYi Road, Wuhan 430065, China.
Wang Y; The State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 299 BaYi Road, Wuhan 430065, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jan 10; Vol. 27 (2). Date of Electronic Publication: 2022 Jan 10.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular/*pathology
Liver Neoplasms/*pathology
MicroRNAs/*genetics
Tryptophan Hydroxylase/*genetics
Animals ; Carcinoma, Hepatocellular/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms/genetics ; Mice, Inbred BALB C ; MicroRNAs/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Tryptophan/genetics ; Tryptophan/metabolism ; Tryptophan Hydroxylase/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Mitochondrial interaction of fibrosis-protective 5-methoxy tryptophan enhances collagen uptake by macrophages.
Autorzy:
Maassen S; Department of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, 050, the Netherlands.
Warner H; Department of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, 050, the Netherlands.
Ioannidis M; Department of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, 050, the Netherlands.
Jansma J; Department of Host-Microbe Interactions, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, 050, the Netherlands.
Markus H; Department of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, 050, the Netherlands.
El Aidy S; Department of Host-Microbe Interactions, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, 050, the Netherlands.
Chiara MD; Institute of Sanitary Research of the Principado de Asturias, Oviedo, Spain; CIBERONC (Network of Biomedical Research in Cancer), Madrid, Spain.
Chiara JL; Institute of General Organic Chemistry, IQOG-CSIC, Madrid, Spain.
Maierhofer L; Institute of General Organic Chemistry, IQOG-CSIC, Madrid, Spain.
Weavers H; School of Biochemistry, Biomedical Sciences, University of Bristol, Bristol, BS8 1TD, United Kingdom.
van den Bogaart G; Department of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, 050, the Netherlands; Department of Medical Biology and Pathology, University Medical Center Groningen, University of Groningen, 050, the Netherlands. Electronic address: .
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Źródło:
Free radical biology & medicine [Free Radic Biol Med] 2022 Aug 01; Vol. 188, pp. 287-297. Date of Electronic Publication: 2022 Jun 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Macrophages*/metabolism
Tryptophan*/metabolism
Tryptophan*/pharmacology
Collagen/metabolism ; Fibrosis ; Humans ; Mitochondria/metabolism
Czasopismo naukowe
Tytuł:
Common materials, extraordinary behavior: An ultrasensitive and enantioselective strategy for D-Tryptophan recognition based on electrochemical .
Autorzy:
Deng Y; Guangxi Key Laboratory of Electrochemical and Magneto-chemical Functional Materials, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China; College of Chemistry and Bioengineering, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China.
Zhang Z; College of Chemistry and Bioengineering, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China.
Pang Y; College of Chemistry and Bioengineering, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China.
Zhou X; College of Chemistry and Bioengineering, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China.
Wang Y; College of Chemistry and Bioengineering, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China.
Zhang Y; College of Chemistry and Bioengineering, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China.
Yuan Y; Guangxi Key Laboratory of Electrochemical and Magneto-chemical Functional Materials, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China; College of Chemistry and Bioengineering, Guilin University of Technology, 12 Jiangan Road, Guilin, 541004, China. Electronic address: .
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Źródło:
Analytica chimica acta [Anal Chim Acta] 2022 Sep 22; Vol. 1227, pp. 340331. Date of Electronic Publication: 2022 Aug 29.
Typ publikacji:
Journal Article
MeSH Terms:
Metal Nanoparticles*
Tryptophan*/analysis
Cysteine ; Electrochemical Techniques/methods ; Gold/chemistry ; Humans ; Stereoisomerism
Czasopismo naukowe
Tytuł:
Off-line two-dimensional LC-MS/MS determination of tryptophan enantiomers in mammalian urine and alteration of their amounts in d-amino acid oxidase deficient mice.
Autorzy:
Ishii C; Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Takizawa N; Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Akita T; Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Mita M; KAGAMI, Inc., 7-7-15, Saito-asagi, Ibaraki, Osaka 567-0085, Japan.
Ide T; Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Konno R; Department of Pharmacological Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi 324-8501, Japan.
Hamase K; Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: .
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Źródło:
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2022 Sep 20; Vol. 219, pp. 114919. Date of Electronic Publication: 2022 Jun 27.
Typ publikacji:
Journal Article
MeSH Terms:
Tandem Mass Spectrometry*/methods
Tryptophan*/chemistry
Amino Acids ; Animals ; Chromatography, Liquid/methods ; Humans ; Mammals ; Mice ; Mice, Inbred C57BL ; Stereoisomerism
Czasopismo naukowe
Tytuł:
Triphenyl phosphate disturbs placental tryptophan metabolism and induces neurobehavior abnormal in male offspring.
Autorzy:
Hong J; School of Public Health, Dongguan Key Laboratory of Environmental Medicine, Guangdong Medical University, Guangdong 523-808, China.
Lu X; School of Public Health, Dongguan Key Laboratory of Environmental Medicine, Guangdong Medical University, Guangdong 523-808, China.
Wang J; Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Jiang M; School of Public Health, Dongguan Key Laboratory of Environmental Medicine, Guangdong Medical University, Guangdong 523-808, China.
Liu Q; School of Public Health, Dongguan Key Laboratory of Environmental Medicine, Guangdong Medical University, Guangdong 523-808, China.
Lin J; School of Public Health, Dongguan Key Laboratory of Environmental Medicine, Guangdong Medical University, Guangdong 523-808, China.
Sun W; China-America Cancer Research Institute, Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, Guangdong, China.
Zhang J; School of Public Health, Dongguan Key Laboratory of Environmental Medicine, Guangdong Medical University, Guangdong 523-808, China.
Shi Y; Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. Electronic address: .
Liu X; School of Public Health, Dongguan Key Laboratory of Environmental Medicine, Guangdong Medical University, Guangdong 523-808, China. Electronic address: .
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Źródło:
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2022 Sep 15; Vol. 243, pp. 113978. Date of Electronic Publication: 2022 Aug 22.
Typ publikacji:
Journal Article
MeSH Terms:
Placenta*/metabolism
Tryptophan*/metabolism
Animals ; Female ; Interleukin-6/metabolism ; Male ; Mammals/metabolism ; Mice ; Organophosphates/toxicity ; Pregnancy ; Serotonin/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł:
The Evaluation of l-Tryptophan Derivatives as Inhibitors of the l-Type Amino Acid Transporter LAT1 (SLC7A5).
Autorzy:
Graff J; Department of Chemistry and Applied Biosciences, ETH Zürich, HCI H405, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
Müller J; Department of Chemistry and Applied Biosciences, ETH Zürich, HCI H405, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
Sadurní A; Department of Chemistry and Applied Biosciences, ETH Zürich, HCI H405, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
Rubin M; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012, Bern, Switzerland.
Canivete Cuissa IA; Department of Chemistry and Applied Biosciences, ETH Zürich, HCI H405, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
Keller C; Department of Chemistry and Applied Biosciences, ETH Zürich, HCI H405, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
Hartmann M; Department of Chemistry and Applied Biosciences, ETH Zürich, HCI H405, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
Singer S; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012, Bern, Switzerland.
Gertsch J; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012, Bern, Switzerland.
Altmann KH; Department of Chemistry and Applied Biosciences, ETH Zürich, HCI H405, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
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Źródło:
ChemMedChem [ChemMedChem] 2022 Sep 05; Vol. 17 (17), pp. e202200308. Date of Electronic Publication: 2022 Aug 10.
Typ publikacji:
Journal Article
MeSH Terms:
Large Neutral Amino Acid-Transporter 1*/metabolism
Tryptophan*/pharmacology
Amino Acids/metabolism ; Drug Discovery ; Humans
Czasopismo naukowe
Tytuł:
Volumetric Absorptive Microsampling (VAMS) for Targeted LC-MS/MS Determination of Tryptophan-Related Biomarkers.
Autorzy:
Protti M; Research Group of Pharmaco-Toxicological Analysis (PTA Lab), Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Cirrincione M; Research Group of Pharmaco-Toxicological Analysis (PTA Lab), Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Mandrioli R; Department for Life Quality Studies (QuVi), Rimini Campus, Alma Mater Studiorum-University of Bologna, Corso d'Augusto 237, 47921 Rimini, Italy.
Rudge J; Neoteryx LLC, 421 Amapola Ave, Torrance, CA 90501, USA.
Regazzoni L; Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy.
Valsecchi V; Department of Neuroscience and Reproductive and Odontostomatological Sciences, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy.
Volpi C; Department of Medicine and Surgery, University of Perugia, Piazzale Gambuli 1, 06132 Perugia, Italy.
Mercolini L; Research Group of Pharmaco-Toxicological Analysis (PTA Lab), Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Sep 01; Vol. 27 (17). Date of Electronic Publication: 2022 Sep 01.
Typ publikacji:
Journal Article
MeSH Terms:
Tandem Mass Spectrometry*/methods
Tryptophan*
Animals ; Biomarkers ; Blood Specimen Collection/methods ; Chromatography, Liquid/methods ; Dried Blood Spot Testing/methods ; Mice
Czasopismo naukowe

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