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Tytuł :
Gene expression of indoleamine and tryptophan dioxygenases and three long non-coding RNAs in breast cancer.
Autorzy :
Ghafouri-Fard S; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Taherian-Esfahani Z; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dashti S; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Kholghi Oskooei V; Department of Laboratory Sciences, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran; Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Taheri M; Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: .
Samsami M; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: .
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Źródło :
Experimental and molecular pathology [Exp Mol Pathol] 2020 Jun; Vol. 114, pp. 104415. Date of Electronic Publication: 2020 Mar 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*genetics
RNA, Long Noncoding/*genetics
Tryptophan Oxygenase/*genetics
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Breast Neoplasms/pathology ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Indoles/metabolism ; Kynurenine/metabolism ; Metabolic Networks and Pathways/genetics ; MicroRNAs/genetics ; Middle Aged ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł :
Dietary tryptophan and bone health: a cross-sectional, population-based study.
Autorzy :
Cleminson JR; School of Medicine, IMPACT, Institute for Innovation in Physical and Mental Health and Clinical Translation, Deakin University, University Hospital Geelong, 285 Ryrie Street, Geelong, Victoria, 3220, Australia. .
Stuart AL; School of Medicine, IMPACT, Institute for Innovation in Physical and Mental Health and Clinical Translation, Deakin University, University Hospital Geelong, 285 Ryrie Street, Geelong, Victoria, 3220, Australia.
Pasco JA; School of Medicine, IMPACT, Institute for Innovation in Physical and Mental Health and Clinical Translation, Deakin University, University Hospital Geelong, 285 Ryrie Street, Geelong, Victoria, 3220, Australia.; Department of Medicine-Western Health, Western Centre for Health Research & Education (WCHRE) Building, The University of Melbourne, Level 3/176 Furlong Road, St Albans, Victoria, 3021, Australia.; Barwon Health, University Hospital Geelong, 285 Ryrie Street, Geelong, Victoria, 3220, Australia.; Department of Epidemiology and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, Victoria, 3004, Australia.
Hodge JM; School of Medicine, IMPACT, Institute for Innovation in Physical and Mental Health and Clinical Translation, Deakin University, University Hospital Geelong, 285 Ryrie Street, Geelong, Victoria, 3220, Australia.; Barwon Health, University Hospital Geelong, 285 Ryrie Street, Geelong, Victoria, 3220, Australia.; Geelong Centre for Emerging Infectious Diseases, University Hospital Geelong, 285 Ryrie Street, Geelong, Victoria, 3220, Australia.
Berk M; School of Medicine, IMPACT, Institute for Innovation in Physical and Mental Health and Clinical Translation, Deakin University, University Hospital Geelong, 285 Ryrie Street, Geelong, Victoria, 3220, Australia.; Barwon Health, University Hospital Geelong, 285 Ryrie Street, Geelong, Victoria, 3220, Australia.; Department of Psychiatry, The Florey Institute for Neuroscience and Mental Health, The National Centre of Excellence in Youth Mental Health, Royal Melbourne Hospital, University of Melbourne, Royal Parade, Parkville, Victoria, 3052, Australia.; Orygen, 35 Poplar Rd, Parkville, Victoria, 3052, Australia.
Samarasinghe RM; School of Medicine, IMPACT, Institute for Innovation in Physical and Mental Health and Clinical Translation, Deakin University, University Hospital Geelong, 285 Ryrie Street, Geelong, Victoria, 3220, Australia.
Williams LJ; School of Medicine, IMPACT, Institute for Innovation in Physical and Mental Health and Clinical Translation, Deakin University, University Hospital Geelong, 285 Ryrie Street, Geelong, Victoria, 3220, Australia.; Barwon Health, University Hospital Geelong, 285 Ryrie Street, Geelong, Victoria, 3220, Australia.
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Źródło :
Archives of osteoporosis [Arch Osteoporos] 2020 Oct 20; Vol. 15 (1), pp. 167. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Density*
Heel/*diagnostic imaging
Population Surveillance/*methods
Tryptophan/*administration & dosage
Adult ; Age Factors ; Aged ; Aged, 80 and over ; Australia/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; New Zealand/epidemiology ; Surveys and Questionnaires ; Tryptophan/blood ; Ultrasonography ; Young Adult
Czasopismo naukowe
Tytuł :
A highly sensitive electrochemical sensor containing nitrogen-doped ordered mesoporous carbon (NOMC) for voltammetric determination of l-tryptophan.
Autorzy :
Zhang Y; Guangdong Food Green Processing and Nutrition Regulation Technologies Research Center, School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Waterhouse GIN; Guangdong Food Green Processing and Nutrition Regulation Technologies Research Center, School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China; School of Chemical Sciences, The University of Auckland, Auckland 1010, New Zealand.
Xiang ZP; School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
Che J; Guangdong Food Green Processing and Nutrition Regulation Technologies Research Center, School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Chen C; Guangdong Food Green Processing and Nutrition Regulation Technologies Research Center, School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Sun W; Guangdong Food Green Processing and Nutrition Regulation Technologies Research Center, School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China; Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), Guangzhou 510641, China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2020 Oct 01; Vol. 326, pp. 126976. Date of Electronic Publication: 2020 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Carbon/*chemistry
Electrochemical Techniques/*methods
Nitrogen/*chemistry
Tryptophan/*analysis
Fluorocarbon Polymers/chemistry ; Limit of Detection ; Oxidation-Reduction ; Porosity ; Proteins/chemistry ; Tryptophan/chemistry
Czasopismo naukowe
Tytuł :
Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction.
Autorzy :
Schupfner M; Institute of Biophysics and Physical Biochemistry, University of Regensburg, D-93053 Regensburg, Germany.
Straub K; Institute of Biophysics and Physical Biochemistry, University of Regensburg, D-93053 Regensburg, Germany.
Busch F; Institute of Biophysics and Physical Biochemistry, University of Regensburg, D-93053 Regensburg, Germany.
Merkl R; Institute of Biophysics and Physical Biochemistry, University of Regensburg, D-93053 Regensburg, Germany.
Sterner R; Institute of Biophysics and Physical Biochemistry, University of Regensburg, D-93053 Regensburg, Germany .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jan 07; Vol. 117 (1), pp. 346-354. Date of Electronic Publication: 2019 Dec 23.
Typ publikacji :
Journal Article
MeSH Terms :
Computational Biology*
Extinction, Biological*
Bacterial Proteins/*genetics
Protein Subunits/*genetics
Tryptophan Synthase/*genetics
Allosteric Regulation/genetics ; Amino Acid Sequence ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Molecular Dynamics Simulation ; Mutagenesis, Site-Directed ; Oceanospirillaceae/genetics ; Oceanospirillaceae/metabolism ; Phylogeny ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Sequence Alignment ; Structural Homology, Protein ; Tryptophan/biosynthesis ; Tryptophan Synthase/chemistry ; Tryptophan Synthase/metabolism
SCR Organism :
Neptuniibacter caesariensis
Czasopismo naukowe
Tytuł :
The autoimmune response elicited by mouse hepatitis virus (MHV-A59) infection is modulated by liver tryptophan-2,3-dioxygenase (TDO).
Autorzy :
Duhalde Vega M; Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina. Electronic address: .
Aparicio JL; Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina.
Mandour MF; Unit of Experimental Medicine, Christian de Duve Institute, Université Catholique de Louvain, Brussels, Belgium; Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Retegui LA; Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina.
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Źródło :
Immunology letters [Immunol Lett] 2020 Jan; Vol. 217, pp. 25-30. Date of Electronic Publication: 2019 Nov 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autoimmune Diseases/*enzymology
Autoimmunity/*drug effects
Coronavirus Infections/*enzymology
Coronavirus Infections/*immunology
Liver/*enzymology
Murine hepatitis virus/*immunology
Tryptophan Oxygenase/*antagonists & inhibitors
Tryptophan Oxygenase/*metabolism
Alarmins/metabolism ; Animals ; Autoantibodies/drug effects ; Autoantibodies/immunology ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/immunology ; Autoimmune Diseases/virology ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Female ; HMGB1 Protein/blood ; HMGB1 Protein/metabolism ; Hydrolases/immunology ; Indoles/therapeutic use ; Liver/drug effects ; Liver/immunology ; Liver/pathology ; Mice ; Mice, Inbred BALB C ; Murine hepatitis virus/drug effects ; Murine hepatitis virus/growth & development ; Tryptophan/metabolism ; Tryptophan Oxygenase/genetics ; Uric Acid/blood ; Uric Acid/metabolism ; Virus Replication/drug effects ; Virus Replication/immunology
Czasopismo naukowe
Tytuł :
Occurrence of melatonin and indolic compounds derived from l-tryptophan yeast metabolism in fermented wort and commercial beers.
Autorzy :
Fernández-Cruz E; Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Facultad de Farmacia, Universidad de Sevilla, C/ Profesor García González 2, 41012 Sevilla, Spain.
Carrasco-Galán F; Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Facultad de Farmacia, Universidad de Sevilla, C/ Profesor García González 2, 41012 Sevilla, Spain.
Cerezo-López AB; Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Facultad de Farmacia, Universidad de Sevilla, C/ Profesor García González 2, 41012 Sevilla, Spain.
Valero E; Departamento de Biología Molecular e Ingeniería Bioquímica, Universidad Pablo de Olavide, Ctra. Utrera, Km 1, Sevilla 41013, Spain.
Morcillo-Parra MÁ; Departament de Bioquimica i Biotecnologia, Facultat d'Enologia, Universitat Rovira i Virgili, C/ Marcel·lí Domingo 1, Campus, Sescelades 43007, Tarragona, Spain.
Beltran G; Departament de Bioquimica i Biotecnologia, Facultat d'Enologia, Universitat Rovira i Virgili, C/ Marcel·lí Domingo 1, Campus, Sescelades 43007, Tarragona, Spain.
Torija MJ; Departament de Bioquimica i Biotecnologia, Facultat d'Enologia, Universitat Rovira i Virgili, C/ Marcel·lí Domingo 1, Campus, Sescelades 43007, Tarragona, Spain.
Troncoso AM; Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Facultad de Farmacia, Universidad de Sevilla, C/ Profesor García González 2, 41012 Sevilla, Spain.
García-Parrilla MC; Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Facultad de Farmacia, Universidad de Sevilla, C/ Profesor García González 2, 41012 Sevilla, Spain. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2020 Nov 30; Vol. 331, pp. 127192. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Beer/*analysis
Beer/*microbiology
Indoles/*metabolism
Melatonin/*metabolism
Tryptophan/*metabolism
Beverages ; Chromatography, High Pressure Liquid/methods ; Fermentation ; Food Analysis/methods ; Food Storage ; Indoles/analysis ; Melatonin/analysis ; Saccharomyces cerevisiae/metabolism ; Serotonin/analogs & derivatives ; Temperature ; Tryptophan/analogs & derivatives
Czasopismo naukowe
Tytuł :
Endogenous tryptophan metabolite 5-Methoxytryptophan inhibits pulmonary fibrosis by downregulating the TGF-β/SMAD3 and PI3K/AKT signaling pathway.
Autorzy :
Fang L; Department of Critical Care Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Chen H; Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Kong R; Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Que J; Department of Critical Care Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Nov 01; Vol. 260, pp. 118399. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation/*drug effects
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Pulmonary Fibrosis/*drug therapy
Smad3 Protein/*metabolism
Transforming Growth Factor beta/*metabolism
Tryptophan/*analogs & derivatives
Animals ; Antibiotics, Antineoplastic/toxicity ; Bleomycin/toxicity ; Cell Differentiation ; Extracellular Matrix ; Humans ; Lung/drug effects ; Lung/metabolism ; Lung/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Myofibroblasts/drug effects ; Myofibroblasts/metabolism ; Myofibroblasts/pathology ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/metabolism ; Pulmonary Fibrosis/pathology ; Smad3 Protein/genetics ; Transforming Growth Factor beta/genetics ; Tryptophan/pharmacology
Czasopismo naukowe
Tytuł :
Role of Indoleamine-2,3-Dioxygenase Inhibitors in Salvage Therapy for Non-Muscle Invasive Bladder Cancer.
Autorzy :
Chu CE; Department of Urology, University of California, San Francisco, 550 16th Street, 6th Floor, San Francisco, CA 94143, USA.
Porten SP; Department of Urology, University of California, San Francisco, 550 16th Street, 6th Floor, San Francisco, CA 94143, USA.
Grossfeld GD; Bristol-Myers Squibb, 3401 Princeton Pike, Lawrenceville, New Jersey 08648, USA.
Meng MV; Department of Urology, University of California, San Francisco, 550 16th Street, 6th Floor, San Francisco, CA 94143, USA. Electronic address: .
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Źródło :
The Urologic clinics of North America [Urol Clin North Am] 2020 Feb; Vol. 47 (1), pp. 111-118.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Acetamides/*administration & dosage
Indoleamine-Pyrrole 2,3,-Dioxygenase/*antagonists & inhibitors
Oximes/*administration & dosage
Quinolines/*administration & dosage
Salvage Therapy/*methods
Sulfonamides/*administration & dosage
Tryptophan/*analogs & derivatives
Urinary Bladder Neoplasms/*therapy
Administration, Intravesical ; Enzyme Inhibitors/administration & dosage ; Humans ; Neoplasm Invasiveness ; Treatment Outcome ; Tryptophan/administration & dosage ; Tryptophan Oxygenase ; Urinary Bladder Neoplasms/immunology ; Urinary Bladder Neoplasms/pathology
Czasopismo naukowe
Tytuł :
A highly efficient modality to block the degradation of tryptophan for cancer immunotherapy: locked nucleic acid-modified antisense oligonucleotides to inhibit human indoleamine 2,3-dioxygenase 1/tryptophan 2,3-dioxygenase expression.
Autorzy :
Klar R; Secarna Pharmaceuticals GmbH & Co. KG, Am Klopferspitz 19, 82152, Planegg, Germany. .
Michel S; Secarna Pharmaceuticals GmbH & Co. KG, Am Klopferspitz 19, 82152, Planegg, Germany.
Schell M; Secarna Pharmaceuticals GmbH & Co. KG, Am Klopferspitz 19, 82152, Planegg, Germany.
Hinterwimmer L; Secarna Pharmaceuticals GmbH & Co. KG, Am Klopferspitz 19, 82152, Planegg, Germany.
Zippelius A; Cancer Immunology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.; Medical Oncology, University Hospital Basel, Basel, Switzerland.
Jaschinski F; Secarna Pharmaceuticals GmbH & Co. KG, Am Klopferspitz 19, 82152, Planegg, Germany. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Jan; Vol. 69 (1), pp. 57-67. Date of Electronic Publication: 2019 Dec 04.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Indoleamine-Pyrrole 2,3,-Dioxygenase/*antagonists & inhibitors
Neoplasms/*therapy
Oligonucleotides, Antisense/*pharmacology
Tryptophan Oxygenase/*antagonists & inhibitors
Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Coculture Techniques ; Drug Screening Assays, Antitumor ; Drug Synergism ; Humans ; Immunotherapy/methods ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Inhibitory Concentration 50 ; Kynurenine/immunology ; Kynurenine/metabolism ; Lymphocyte Activation/drug effects ; Neoplasms/immunology ; Oligonucleotides/administration & dosage ; Oligonucleotides/chemistry ; Oligonucleotides, Antisense/chemistry ; T-Lymphocytes/immunology ; Tryptophan/immunology ; Tryptophan/metabolism ; Tryptophan Oxygenase/metabolism
Czasopismo naukowe
Tytuł :
Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint Inhibitors.
Autorzy :
Schramme F; Ludwig Institute for Cancer Research, Brussels, Belgium.; de Duve Institute, UCLouvain, Brussels, Belgium.
Crosignani S; iTeos Therapeutics, Gosselies, Belgium.
Frederix K; iTeos Therapeutics, Gosselies, Belgium.
Hoffmann D; Ludwig Institute for Cancer Research, Brussels, Belgium.; de Duve Institute, UCLouvain, Brussels, Belgium.
Pilotte L; Ludwig Institute for Cancer Research, Brussels, Belgium.; de Duve Institute, UCLouvain, Brussels, Belgium.
Stroobant V; Ludwig Institute for Cancer Research, Brussels, Belgium.; de Duve Institute, UCLouvain, Brussels, Belgium.
Preillon J; iTeos Therapeutics, Gosselies, Belgium.
Driessens G; iTeos Therapeutics, Gosselies, Belgium.
Van den Eynde BJ; Ludwig Institute for Cancer Research, Brussels, Belgium. .; de Duve Institute, UCLouvain, Brussels, Belgium.; Walloon Excellence in Life Sciences and Biotechnology, Brussels, Belgium.
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Źródło :
Cancer immunology research [Cancer Immunol Res] 2020 Jan; Vol. 8 (1), pp. 32-45. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents, Immunological/*pharmacology
CTLA-4 Antigen/*antagonists & inhibitors
Colonic Neoplasms/*drug therapy
Enzyme Inhibitors/*pharmacology
Neoplasms, Experimental/*drug therapy
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Tryptophan Oxygenase/*antagonists & inhibitors
Animals ; CTLA-4 Antigen/immunology ; Cell Line, Tumor ; Colonic Neoplasms/enzymology ; Colonic Neoplasms/immunology ; Drug Synergism ; Humans ; Kynurenine/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Neoplasms, Experimental/enzymology ; Neoplasms, Experimental/immunology ; Programmed Cell Death 1 Receptor/immunology ; Small Molecule Libraries/pharmacology ; Tryptophan/metabolism ; Tryptophan Oxygenase/immunology
Czasopismo naukowe
Tytuł :
Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers.
Autorzy :
Hoffmann D; Ludwig Institute for Cancer Research, Brussels, Belgium.; de Duve Institute, UCLouvain, Brussels, Belgium.
Dvorakova T; Ludwig Institute for Cancer Research, Brussels, Belgium.; de Duve Institute, UCLouvain, Brussels, Belgium.
Stroobant V; Ludwig Institute for Cancer Research, Brussels, Belgium.; de Duve Institute, UCLouvain, Brussels, Belgium.
Bouzin C; IREC Imaging Platform, Institut de Recherche Expérimentale et Clinique, UCLouvain, Brussels, Belgium.
Daumerie A; IREC Imaging Platform, Institut de Recherche Expérimentale et Clinique, UCLouvain, Brussels, Belgium.
Solvay M; Ludwig Institute for Cancer Research, Brussels, Belgium.; de Duve Institute, UCLouvain, Brussels, Belgium.
Klaessens S; Ludwig Institute for Cancer Research, Brussels, Belgium.; de Duve Institute, UCLouvain, Brussels, Belgium.
Letellier MC; iTeos Therapeutics, Gosselies, Belgium.
Renauld JC; de Duve Institute, UCLouvain, Brussels, Belgium.
van Baren N; de Duve Institute, UCLouvain, Brussels, Belgium.
Lelotte J; Service d'anatomopathologie, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Marbaix E; de Duve Institute, UCLouvain, Brussels, Belgium.; Service d'anatomopathologie, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Van den Eynde BJ; Ludwig Institute for Cancer Research, Brussels, Belgium. .; de Duve Institute, UCLouvain, Brussels, Belgium.; Walloon Excellence in Life Sciences and Biotechnology, Brussels, Belgium.
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Źródło :
Cancer immunology research [Cancer Immunol Res] 2020 Jan; Vol. 8 (1), pp. 19-31. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*immunology
Biomarkers, Tumor/*metabolism
Lung Diseases/*metabolism
Lymphocytes, Tumor-Infiltrating/*metabolism
Neoplasms/*metabolism
Pericytes/*pathology
Tryptophan Oxygenase/*metabolism
Animals ; Antibodies, Monoclonal/isolation & purification ; Antibody Formation ; Cell Line, Tumor ; Humans ; Lung Diseases/immunology ; Lung Diseases/pathology ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Neoplasm Grading ; Neoplasms/immunology ; Neoplasms/pathology ; Pericytes/metabolism ; Tryptophan/metabolism ; Tryptophan Oxygenase/immunology
Czasopismo naukowe
Tytuł :
Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma.
Autorzy :
Mohapatra SR; DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sadik A; DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Bioscience, Heidelberg University, Heidelberg, Germany.
Tykocinski LO; Division of Rheumatology, Department of Medicine V, University Hospital of Heidelberg, Heidelberg, Germany.
Dietze J; Department of Arctic and Marine Biology, UiT The Arctic University of Norway, Tromsø, Norway.
Poschet G; Centre for Organismal Studies (COS), University of Heidelberg, Heidelberg, Germany.
Heiland I; Department of Arctic and Marine Biology, UiT The Arctic University of Norway, Tromsø, Norway.
Opitz CA; DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Neurology Clinic and National Center for Tumor Diseases, University Hospital of Heidelberg, Heidelberg, Germany.
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Źródło :
Frontiers in immunology [Front Immunol] 2019 Dec 04; Vol. 10, pp. 2762. Date of Electronic Publication: 2019 Dec 04 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Neoplasms/*immunology
Glioblastoma/*immunology
Hypoxia-Inducible Factor 1, alpha Subunit/*physiology
Tryptophan Oxygenase/*genetics
Brain Neoplasms/enzymology ; Cell Hypoxia ; Cell Line, Tumor ; Gene Expression Regulation, Enzymologic ; Glioblastoma/enzymology ; Humans ; Immune Tolerance ; Kynurenine/metabolism ; Lymphocyte Activation ; T-Lymphocytes/immunology ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł :
Investigating the effects of incremental conditioning and supplemental dietary tryptophan on the voluntary activity and behaviour of mid-distance training sled dogs.
Autorzy :
Robinson E; Department of Animal Biosciences, University of Guelph, Guelph, Ontario, Canada.
Templeman JR; Department of Animal Biosciences, University of Guelph, Guelph, Ontario, Canada.
Thornton E; Department of Animal Biosciences, University of Guelph, Guelph, Ontario, Canada.
Croney CC; Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, United States of America.; Department of Animal Sciences, Purdue University, West Lafayette, Indiana, United States of America.
Niel L; Department of Population Medicine, University of Guelph, Guelph, Ontario, Canada.
Shoveller AK; Department of Animal Biosciences, University of Guelph, Guelph, Ontario, Canada.
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Źródło :
PloS one [PLoS One] 2020 Aug 13; Vol. 15 (8), pp. e0232643. Date of Electronic Publication: 2020 Aug 13 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dietary Supplements*
Dogs/*physiology
Physical Conditioning, Animal/*methods
Tryptophan/*administration & dosage
Animals ; Behavior, Animal/physiology ; Dogs/psychology ; Endurance Training/methods ; Endurance Training/veterinary ; Female ; Humans ; Linear Models ; Male ; Motor Activity/physiology ; Physical Conditioning, Animal/physiology ; Running/physiology ; Serotonin/biosynthesis ; Serotonin/physiology ; Snow Sports ; Time Factors ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł :
Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor.
Autorzy :
Scott SA; Department of Microbiology, Cornell University, Ithaca, NY 14853.
Fu J; Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853.; Cornell Institute of Host-Microbe Interactions and Disease, Cornell University, Ithaca, NY 14853.
Chang PV; Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853; .; Cornell Institute of Host-Microbe Interactions and Disease, Cornell University, Ithaca, NY 14853.; Cornell Center for Immunology, Cornell University, Ithaca, NY 14853.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 11; Vol. 117 (32), pp. 19376-19387. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Gastrointestinal Microbiome/*physiology
Intestinal Mucosa/*metabolism
Intestinal Mucosa/*microbiology
Receptors, Aryl Hydrocarbon/*metabolism
Tryptophan/*metabolism
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Caco-2 Cells ; Colitis, Ulcerative/diet therapy ; Colitis, Ulcerative/microbiology ; Colitis, Ulcerative/pathology ; Cytoskeletal Proteins/genetics ; Cytoskeletal Proteins/metabolism ; Disease Models, Animal ; Humans ; Inflammation ; Intestinal Mucosa/pathology ; Mice ; Mice, Knockout ; Nonmuscle Myosin Type IIA/metabolism ; Permeability ; Receptors, Aryl Hydrocarbon/genetics ; Tryptophan/administration & dosage
Czasopismo naukowe
Tytuł :
Clinical value of full-length tryptophanyl-tRNA synthetase for sepsis detection in critically ill patients - A retrospective clinical assessment.
Autorzy :
Choi JS; Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Gyeonggi-do, Republic of Korea.
Yoon BR; Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Shin JH; Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Lee SH; Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Leem AY; Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Park MS; Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kim YS; Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Chung KS; Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: .
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Źródło :
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2020 Aug; Vol. 97, pp. 260-266. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji :
Journal Article
MeSH Terms :
Sepsis/*diagnosis
Tryptophan-tRNA Ligase/*blood
APACHE ; Aged ; C-Reactive Protein/metabolism ; Critical Illness ; Female ; Hospitalization ; Humans ; Intensive Care Units ; Interleukin-6/blood ; Male ; Middle Aged ; Organ Dysfunction Scores ; Procalcitonin/blood ; Prognosis ; Retrospective Studies ; Sepsis/blood ; Sepsis/enzymology ; Tryptophan-tRNA Ligase/genetics ; Universities
Czasopismo naukowe
Tytuł :
Targeting β-tubulin/CCT-β complex induces apoptosis and suppresses migration and invasion of highly metastatic lung adenocarcinoma.
Autorzy :
Liu YJ; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Chang YJ; Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan.
Kuo YT; Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan.
Liang PH; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.; Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan.
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Źródło :
Carcinogenesis [Carcinogenesis] 2020 Jul 10; Vol. 41 (5), pp. 699-710.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Cell Movement*
Adenocarcinoma of Lung/*pathology
Chaperonin Containing TCP-1/*antagonists & inhibitors
Lung Neoplasms/*pathology
Tryptophan/*pharmacology
Tubulin/*chemistry
Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/metabolism ; Cell Proliferation ; Epithelial-Mesenchymal Transition ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Neoplasm Invasiveness ; Tryptophan/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Dietary L-Tryptophan Regulates Colonic Serotonin Homeostasis in Mice with Dextran Sodium Sulfate-Induced Colitis.
Autorzy :
Wang B; State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, P.R. China.
Sun S; State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, P.R. China.
Liu M; State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, P.R. China.
Chen H; State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, P.R. China.
Liu N; State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, P.R. China.
Wu Z; State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, P.R. China.; Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, P.R. China.
Wu G; Department of Animal Science, Texas A&M University, College Station, TX, USA.
Dai Z; State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, P.R. China.
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Źródło :
The Journal of nutrition [J Nutr] 2020 Jul 01; Vol. 150 (7), pp. 1966-1976.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dietary Supplements*
Colitis/*metabolism
Colon/*metabolism
Dextran Sulfate/*toxicity
Homeostasis/*drug effects
Serotonin/*metabolism
Serotonin Antagonists/*pharmacology
Tryptophan/*pharmacology
Animals ; Colitis/chemically induced ; Diet ; Male ; Mice ; Mice, Inbred C57BL ; Piperazines/pharmacology ; Random Allocation ; Serotonin Antagonists/administration & dosage ; Tryptophan/administration & dosage
Czasopismo naukowe
Tytuł :
[Perinatal antibiotics exposure causes increase in serum 5-hydroxytryptamine level as well as changes in behavior and gastrointestinal motility in the male offspring in mice].
Autorzy :
Zou YY; Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Wu XY; Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Shu L; Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Ji PL; Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Gong HS; Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Rong WF; Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. .
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Źródło :
Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 2020 Jun 25; Vol. 72 (3), pp. 285-298.
Typ publikacji :
Journal Article
MeSH Terms :
Serotonin*
Tryptophan Hydroxylase*
Animals ; Anti-Bacterial Agents/pharmacology ; Colon ; Female ; Gastrointestinal Motility ; Male ; Mice ; Pregnancy ; Rats
Czasopismo naukowe
Tytuł :
Is the tryptophan codon of gene vif the Achilles' heel of HIV-1?
Autorzy :
Villanova F; Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
Barreiros M; Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
Leal É; Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
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Źródło :
PloS one [PLoS One] 2020 Jun 22; Vol. 15 (6), pp. e0225563. Date of Electronic Publication: 2020 Jun 22 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Tryptophan*
Codon/*genetics
HIV-1/*genetics
vif Gene Products, Human Immunodeficiency Virus/*genetics
CD4 Lymphocyte Count ; Codon, Terminator/genetics ; HIV-1/physiology ; Mutation ; Viral Load/genetics
Czasopismo naukowe
Tytuł :
DEPRESSION IN THE STRUCTURE OF SOMATOFORM DISORDERS IN CHILDREN, ITS SIGNIFICANCE, THE ROLE OF SEROTONIN AND TRYPTOPHANE IN THE EMERGENCE OF THESE DISORDERS.
Autorzy :
Pypa L; National Pyrogov Memorial Medical University, Vinnytsia, Ukraine.
Lysytsia Y; National Pyrogov Memorial Medical University, Vinnytsia, Ukraine.
Svistilnik R; National Pyrogov Memorial Medical University, Vinnytsia, Ukraine.
Rimsha S; National Pyrogov Memorial Medical University, Vinnytsia, Ukraine.
Kernychnyi V; National Pyrogov Memorial Medical University, Vinnytsia, Ukraine.
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Źródło :
Georgian medical news [Georgian Med News] 2020 Jun (303), pp. 142-148.
Typ publikacji :
Journal Article
MeSH Terms :
Serotonin*
Tryptophan*
Child ; Child, Preschool ; Female ; Humans ; Male ; Somatoform Disorders
Czasopismo naukowe

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