Temat: "TRYPTOPHAN hydroxylase" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: In Vitro and In Vivo Chaperone Effect of (R)-2-amino-6-(1R, 2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropterin-4(3H)-one on the C1473G Mutant Tryptophan Hydroxylase 2.
Autorzy:: Arefieva AB; Department of Genetic Collections of Neural Disorders, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Komleva PD; Department of Psychoneuropharmacology, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Naumenko VS; Department of Psychoneuropharmacology, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Departments of Behavioral Neurogenomics, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Khotskin NV; Department of Genetic Collections of Neural Disorders, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Kulikov AV; Department of Genetic Collections of Neural Disorders, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2023 Sep 27; Vol. 13 (10). Date of Electronic Publication: 2023 Sep 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Tryptophan Hydroxylase*/genetics
Tryptophan Hydroxylase*/metabolism
Brain*/metabolism
Mice ; Animals ; Mice, Inbred C57BL ; Pterins/metabolism ; Mice, Inbred BALB C ; Mammals/metabolism

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Tytuł:: Effects of the Combination of the C1473G Mutation in the Tph2 Gene and Lethal Yellow Mutations in the Raly-Agouti Locus on Behavior, Brain 5-HT and Melanocortin Systems in Mice.
Autorzy:: Komleva PD; Department of Psychoneuropharmacology, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Alhalabi G; Department of Genetic Collections of Neural Disorders, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Izyurov AE; Department of Genetics of Industrial Microorganisms, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Khotskin NV; Department of Genetic Collections of Neural Disorders, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Kulikov AV; Department of Genetic Collections of Neural Disorders, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2023 Jun 08; Vol. 13 (6). Date of Electronic Publication: 2023 Jun 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brain*/metabolism
Depression*/etiology
Depression*/genetics
Depression*/metabolism
Obesity*/etiology
Obesity*/genetics
Obesity*/metabolism
Serotonin*/genetics
Serotonin*/metabolism
Tryptophan Hydroxylase*/genetics
Tryptophan Hydroxylase*/metabolism
Melanocortins*/genetics
Melanocortins*/metabolism
Animals ; Mice ; Mutation ; Swimming

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Skocz do pozycji: 3.

Tytuł:: Tryptophan Hydroxylase 2 Deficiency Modifies the Effects of Fluoxetine and Pargyline on the Behavior, 5-HT- and BDNF-Systems in the Brain of Zebrafish ( Danio rerio ).
Autorzy:: Evsiukova VS; Department of Psychoneuropharmacology, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Bazovkina D; Department of Behavioral Neurogenomics, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Bazhenova E; Department of Genetic Collections of Neural Disorders, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Kulikova EA; Department of Psychoneuropharmacology, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Kulikov AV; Department of Genetic Collections of Neural Disorders, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 27; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 27.
Typ publikacji:: Journal Article
MeSH Terms:: Behavior, Animal/*drug effects
Brain/*drug effects
Brain-Derived Neurotrophic Factor/*metabolism
Fluoxetine/*pharmacology
Pargyline/*pharmacology
Serotonin/*metabolism
Tryptophan Hydroxylase/*deficiency
Zebrafish Proteins/*deficiency
Animals ; Antidepressive Agents/pharmacology ; Brain/enzymology ; Brain/metabolism ; Disease Models, Animal ; Monoamine Oxidase Inhibitors/pharmacology ; Selective Serotonin Reuptake Inhibitors/pharmacology ; Tryptophan Hydroxylase/metabolism ; Zebrafish ; Zebrafish Proteins/metabolism

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Skocz do pozycji: 4.

Tytuł:: Serotonin deficiency induced after brain maturation rescues consequences of early life adversity.
Autorzy:: Aboagye B; Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, Center of Mental Health, University of Würzburg, Margarete-Höppel-Platz 1, 97080, Würzburg, Germany.; Department of Biomedical and Forensic Science, School of Biological Sciences, University of Cape Coast, Cape Coast, Ghana.
Weber T; Department of Molecular Biology, Central Institute of Mental Health, Medical Faculty Mannheim , Heidelberg University, Mannheim, Germany.; MEDIAN Clinic Wilhelmsheim, Oppenweiler, Germany.
Merdian HL; School of Psychology, University of Lincoln, Lincoln, UK.
Bartsch D; Department of Molecular Biology, Central Institute of Mental Health, Medical Faculty Mannheim , Heidelberg University, Mannheim, Germany.
Lesch KP; Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, Center of Mental Health, University of Würzburg, Margarete-Höppel-Platz 1, 97080, Würzburg, Germany. .; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russia. .; Department of Psychiatry and Psychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands. .
Waider J; Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, Center of Mental Health, University of Würzburg, Margarete-Höppel-Platz 1, 97080, Würzburg, Germany. Waider_.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Mar 08; Vol. 11 (1), pp. 5368. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brain/*growth & development
Serotonin/*metabolism
Tryptophan Hydroxylase/*metabolism
Animals ; Emotions ; Male ; Maternal Deprivation ; Mice ; Mice, Knockout ; Serotonin/genetics ; Tryptophan Hydroxylase/genetics

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Skocz do pozycji: 5.

Tytuł:: A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis.
Autorzy:: Park S; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Kim Y; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Lee J; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Lee JY; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Kim H; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Lee S; Department of School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Oh CM; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Feb 28; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 28.
Typ publikacji:: Journal Article
MeSH Terms:: Metabolome*
Adipose Tissue/*metabolism
Brain/*metabolism
Intestines/*physiology
Serotonin/*metabolism
Tryptophan Hydroxylase/*metabolism
Homeostasis ; Humans ; Systems Biology ; Transcriptome ; Tryptophan Hydroxylase/genetics

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Skocz do pozycji: 6.

Tytuł:: The Effect of Chronic Mild Stress and Escitalopram on the Expression and Methylation Levels of Genes Involved in the Oxidative and Nitrosative Stresses as Well as Tryptophan Catabolites Pathway in the Blood and Brain Structures.
Autorzy:: Wigner P; Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
Synowiec E; Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
Jóźwiak P; Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
Czarny P; Department of Medical Biochemistry, Medical University of Lodz, 90-647 Lodz, Poland.
Bijak M; Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
Białek K; Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.
Szemraj J; Department of Medical Biochemistry, Medical University of Lodz, 90-647 Lodz, Poland.
Gruca P; Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland.
Papp M; Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland.
Śliwiński T; Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-136 Lodz, Poland.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Dec 22; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 22.
Typ publikacji:: Journal Article
MeSH Terms:: Brain/*drug effects
Citalopram/*pharmacology
DNA Methylation/*drug effects
Gene Expression Regulation/*drug effects
Metabolic Networks and Pathways/*genetics
Stress, Psychological/*physiopathology
Tryptophan/*metabolism
Animals ; Antidepressive Agents, Second-Generation/pharmacology ; Brain/metabolism ; Catalase/genetics ; Catalase/metabolism ; Chronic Disease ; Depression/genetics ; Depression/metabolism ; Glutathione Peroxidase/genetics ; Glutathione Peroxidase/metabolism ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Male ; Nitric Oxide Synthase Type I/genetics ; Nitric Oxide Synthase Type I/metabolism ; Nitrosative Stress ; Oxidative Stress ; Rats, Wistar ; Tryptophan Hydroxylase/genetics ; Tryptophan Hydroxylase/metabolism ; Glutathione Peroxidase GPX1

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Skocz do pozycji: 7.

Tytuł:: Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2.
Autorzy:: Koshimizu H; Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.
Hirata N; Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.
Takao K; Life Science Research Center, University of Toyama, Toyama, Japan.
Toyama K; Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.
Ichinose T; Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.
Furuya S; Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.
Miyakawa T; Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.; Pokaż więcej
Źródło:: Neuropsychopharmacology reports [Neuropsychopharmacol Rep] 2019 Mar; Vol. 39 (1), pp. 56-60. Date of Electronic Publication: 2018 Nov 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Behavior, Animal*
Mutation, Missense*
Amino Acids/*metabolism
Brain/*metabolism
Tryptophan Hydroxylase/*genetics
Animals ; Epinephrine/metabolism ; Learning ; Locomotion ; Male ; Mice ; Mice, Inbred C57BL ; Serotonin/metabolism

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Skocz do pozycji: 8.

Tytuł:: Brain serotonin deficiency affects female aggression.
Autorzy:: Kästner N; Department of Behavioural Biology, University of Münster, Münster, Germany. .; Münster Graduate School of Evolution, University of Münster, Münster, Germany. .
Richter SH; Department of Behavioural Biology, University of Münster, Münster, Germany.; Münster Graduate School of Evolution, University of Münster, Münster, Germany.
Urbanik S; Department of Mathematical Statistics and Applications in Science, Technical University of Dortmund, Dortmund, Germany.
Kunert J; Department of Mathematical Statistics and Applications in Science, Technical University of Dortmund, Dortmund, Germany.
Waider J; Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany.
Lesch KP; Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany.; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.; Department of Neuroscience, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands.
Kaiser S; Department of Behavioural Biology, University of Münster, Münster, Germany.; Münster Graduate School of Evolution, University of Münster, Münster, Germany.
Sachser N; Department of Behavioural Biology, University of Münster, Münster, Germany.; Münster Graduate School of Evolution, University of Münster, Münster, Germany.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Feb 04; Vol. 9 (1), pp. 1366. Date of Electronic Publication: 2019 Feb 04.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Aggression/*physiology
Brain/*metabolism
Serotonin/*deficiency
Animals ; Female ; Genotype ; Mice, Knockout ; Serotonin/metabolism ; Social Behavior ; Tryptophan Hydroxylase/deficiency ; Tryptophan Hydroxylase/genetics

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Skocz do pozycji: 9.

Tytuł:: Brain serotonin critically contributes to the biological effects of electroconvulsive seizures.
Autorzy:: Kronenberg G; Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsmedizin Rostock, 18147, Rostock, Germany.; Department of Psychiatry and Psychotherapy, Charité-University Medicine Berlin, Charitéplatz 1, 10117, Berlin, Germany.; Berlin Institute of Health, 10178, Berlin, Germany.
Petermann M; Berlin Institute of Health, 10178, Berlin, Germany.; Max Delbruck Center for Molecular Medicine (MDC), 13125, Berlin, Germany.
Dormann C; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim (CIMH), University of Heidelberg, J 5, 68159, Mannheim, Germany.
Bader M; Berlin Institute of Health, 10178, Berlin, Germany.; Max Delbruck Center for Molecular Medicine (MDC), 13125, Berlin, Germany.; Charité-University Medicine Berlin, 10117, Berlin, Germany.
Gass P; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim (CIMH), University of Heidelberg, J 5, 68159, Mannheim, Germany.
Hellweg R; Department of Psychiatry and Psychotherapy, Charité-University Medicine Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Klempin F; Department of Psychiatry and Psychotherapy, Charité-University Medicine Berlin, Charitéplatz 1, 10117, Berlin, Germany. .; Berlin Institute of Health, 10178, Berlin, Germany. .; Max Delbruck Center for Molecular Medicine (MDC), 13125, Berlin, Germany. .; Pokaż więcej
Źródło:: European archives of psychiatry and clinical neuroscience [Eur Arch Psychiatry Clin Neurosci] 2018 Dec; Vol. 268 (8), pp. 861-864. Date of Electronic Publication: 2018 Jul 17.
Typ publikacji:: Journal Article
MeSH Terms:: Brain/*metabolism
Electroconvulsive Therapy/*methods
Seizures/*therapy
Serotonin/*metabolism
Animals ; Bromodeoxyuridine/metabolism ; Exploratory Behavior/physiology ; Female ; Hippocampus/physiology ; Maze Learning/physiology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurogenesis/physiology ; Seizures/genetics ; Statistics, Nonparametric ; Swimming/psychology ; Tryptophan Hydroxylase/deficiency ; Tryptophan Hydroxylase/genetics

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Skocz do pozycji: 10.

Tytuł:: Brain serotonin determines maternal behavior and offspring survival.
Autorzy:: Angoa-Pérez M; Research & Development Service, John D. Dingell VA Medical Center, Detroit, MI, USA; Department of Psychiatry & Behavioral Neurosciences, Detroit, MI, USA.
Kane MJ
Sykes CE
Perrine SA
Church MW
Kuhn DM; Pokaż więcej
Źródło:: Genes, brain, and behavior [Genes Brain Behav] 2014 Sep; Vol. 13 (7), pp. 579-91. Date of Electronic Publication: 2014 Aug 28.
Typ publikacji:: Journal Article
MeSH Terms:: Maternal Behavior*
Brain/*metabolism
Serotonin/*metabolism
Tryptophan Hydroxylase/*metabolism
Animals ; Animals, Newborn/physiology ; Female ; Genotype ; Male ; Mice ; Mice, Inbred C57BL ; Thinness ; Tryptophan Hydroxylase/genetics

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Skocz do pozycji: 11.

Tytuł:: Genetic polymorphisms and their association with brain and behavioural measures in heterogeneous stock mice.
Autorzy:: Janecka M; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Marzi SJ; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Parsons MJ; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Mammalian Genetics Unit, MRC Harwell, Oxfordshire, UK.
Liu L; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Paya-Cano JL; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Smith RG; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Fernandes C; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Schalkwyk LC; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; School of Biological Sciences, University of Essex, Colchester, UK.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2017 Feb 01; Vol. 7, pp. 41204. Date of Electronic Publication: 2017 Feb 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Behavior, Animal*
Polymorphism, Single Nucleotide*
Quantitative Trait Loci*
Brain/*metabolism
Genetic Association Studies/*methods
Animals ; Gene Expression ; Genetic Heterogeneity ; Male ; Mice ; Microtubule-Associated Proteins/genetics ; Receptors, Serotonin, 5-HT3/genetics ; Sp2 Transcription Factor/genetics ; Tryptophan Hydroxylase/genetics

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Skocz do pozycji: 12.

Tytuł:: Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster.
Autorzy:: Majeed ZR; Department of Biology, University of Kentucky, Lexington, KY 40506, USA; Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, Iraq.
Abdeljaber E; Department of Biology, University of Kentucky, Lexington, KY 40506, USA.
Soveland R; Department of Biology, University of Kentucky, Lexington, KY 40506, USA; Paul Laurence Dunbar High School, Lexington, KY 40513, USA.
Cornwell K; Department of Biology, University of Kentucky, Lexington, KY 40506, USA.
Bankemper A; Department of Biology, University of Kentucky, Lexington, KY 40506, USA.
Koch F; Veterinärmedizinische Fakultät, Universität Leipzig, 04103 Leipzig, Germany.
Cooper RL; Department of Biology, University of Kentucky, Lexington, KY 40506, USA.; Pokaż więcej
Źródło:: Neural plasticity [Neural Plast] 2016; Vol. 2016, pp. 7291438. Date of Electronic Publication: 2016 Feb 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Locomotion*/drug effects
Brain/*physiology
Feeding Behavior/*physiology
Serotonergic Neurons/*physiology
Serotonin/*physiology
5-Hydroxytryptophan/administration & dosage ; Animals ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Enzyme Inhibitors/administration & dosage ; Excitatory Postsynaptic Potentials ; Feeding Behavior/drug effects ; Fenclonine/administration & dosage ; Protein Subunits/metabolism ; Receptors, Serotonin/physiology ; Sensory Receptor Cells/physiology ; Serotonin/administration & dosage ; Tryptophan Hydroxylase/metabolism

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Skocz do pozycji: 13.

Tytuł:: Neuroscience. Mutant gene tied to poor serotonin production and depression.
Autorzy:: Holden C; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2004 Dec 17; Vol. 306 (5704), pp. 2023.
Typ publikacji:: Wiadomości
MeSH Terms:: Mutation*
Brain/*metabolism
Depressive Disorder/*genetics
Serotonin/*biosynthesis
Tryptophan Hydroxylase/*genetics
Aged ; Alleles ; Depressive Disorder/drug therapy ; Depressive Disorder/metabolism ; Genetic Predisposition to Disease ; Humans ; Selective Serotonin Reuptake Inhibitors/therapeutic use ; Tryptophan Hydroxylase/chemistry ; Tryptophan Hydroxylase/metabolism

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Skocz do pozycji: 14.

Tytuł:: Tryptophan hydroxylase-2 controls brain serotonin synthesis.
Autorzy:: Zhang X; Howard Hughes Medical Institute Laboratory, Department of Cell Biology, and Center for Models of Human Disease, Institute for Genome Sciences and Policy, Box 3287, Duke University Medical Center, Durham, NC 27710, USA.
Beaulieu JM
Sotnikova TD
Gainetdinov RR
Caron MG; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2004 Jul 09; Vol. 305 (5681), pp. 217.
Typ publikacji:: Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:: Brain/*metabolism
Serotonin/*biosynthesis
Tryptophan Hydroxylase/*metabolism
Alleles ; Amino Acid Sequence ; Animals ; Brain Stem/metabolism ; Corpus Striatum/metabolism ; Frontal Lobe/metabolism ; Humans ; Mice ; Mice, Inbred Strains ; Molecular Sequence Data ; PC12 Cells ; Polymorphism, Single Nucleotide ; Rats ; Reverse Transcriptase Polymerase Chain Reaction ; Transfection ; Tryptophan Hydroxylase/chemistry ; Tryptophan Hydroxylase/genetics

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Skocz do pozycji: 15.

Tytuł:: Synthesis of serotonin by a second tryptophan hydroxylase isoform.
Autorzy:: Walther DJ; Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Strasse 10, D-13092 Berlin-Buch, Germany. />Peter JU
Bashammakh S
Hörtnagl H
Voits M
Fink H
Bader M; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2003 Jan 03; Vol. 299 (5603), pp. 76.
Typ publikacji:: Journal Article
MeSH Terms:: Brain/*enzymology
Serotonin/*biosynthesis
Tryptophan Hydroxylase/*metabolism
Amino Acid Sequence ; Animals ; Brain/metabolism ; COS Cells ; Cloning, Molecular ; Conserved Sequence ; DNA, Complementary ; Duodenum/enzymology ; Duodenum/metabolism ; Humans ; Hydroxylation ; Isoenzymes/chemistry ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Transfection ; Tryptophan Hydroxylase/chemistry ; Tryptophan Hydroxylase/genetics

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Skocz do pozycji: 16.

Tytuł:: Association between Tph2 gene polymorphism, brain tryptophan hydroxylase activity and aggressiveness in mouse strains.
Autorzy:: Kulikov AV; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, ave. Lavryentyev 10, 630090 Novosibirsk, Russia. />Osipova DV
Naumenko VS
Popova NK; Pokaż więcej
Źródło:: Genes, brain, and behavior [Genes Brain Behav] 2005 Nov; Vol. 4 (8), pp. 482-5.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Aggression/*physiology
Behavior, Animal/*physiology
Brain/*enzymology
Polymorphism, Single Nucleotide/*genetics
Tryptophan Hydroxylase/*genetics
Animals ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Inbred Strains ; Species Specificity ; Statistics, Nonparametric ; Tryptophan Hydroxylase/physiology

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Skocz do pozycji: 17.

Tytuł:: Brain serotonin signaling does not determine sexual preference in male mice.
Autorzy:: Angoa-Pérez M; Research & Development Service, John D. Dingell VA Medical Center, Detroit, Michigan, United States of America; Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, United States of America.
Herrera-Mundo N; Research & Development Service, John D. Dingell VA Medical Center, Detroit, Michigan, United States of America; Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, United States of America.
Kane MJ; Research & Development Service, John D. Dingell VA Medical Center, Detroit, Michigan, United States of America; Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, United States of America.
Sykes CE; Research & Development Service, John D. Dingell VA Medical Center, Detroit, Michigan, United States of America; Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, United States of America.
Anneken JH; Research & Development Service, John D. Dingell VA Medical Center, Detroit, Michigan, United States of America; Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, United States of America.
Francescutti DM; Research & Development Service, John D. Dingell VA Medical Center, Detroit, Michigan, United States of America; Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, United States of America.
Kuhn DM; Research & Development Service, John D. Dingell VA Medical Center, Detroit, Michigan, United States of America; Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Feb 23; Vol. 10 (2), pp. e0118603. Date of Electronic Publication: 2015 Feb 23 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Sexual Behavior, Animal*
Signal Transduction*
Brain/*metabolism
Serotonin/*metabolism
Animals ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Tryptophan Hydroxylase/genetics ; Tryptophan Hydroxylase/physiology

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Skocz do pozycji: 18.

Tytuł:: Serotonin depletion counteracts sex differences in anxiety-related behaviour in rat.
Autorzy:: Näslund J; Department of Pharmacology, Institute of Neuroscience and Physiology at the Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 13, 413 90, Gothenburg, Sweden, .
Studer E
Nilsson K
Westberg L
Eriksson E; Pokaż więcej
Źródło:: Psychopharmacology [Psychopharmacology (Berl)] 2013 Nov; Vol. 230 (1), pp. 29-35. Date of Electronic Publication: 2013 May 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anxiety/*physiopathology
Behavior, Animal/*physiology
Brain/*metabolism
Serotonin/*metabolism
Animals ; Female ; Fenclonine/pharmacology ; Male ; Maze Learning/physiology ; Rats ; Rats, Wistar ; Sex Factors ; Time Factors ; Tryptophan Hydroxylase/antagonists & inhibitors