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Tytuł:
Effects of the Combination of the C1473G Mutation in the Tph2 Gene and Lethal Yellow Mutations in the Raly-Agouti Locus on Behavior, Brain 5-HT and Melanocortin Systems in Mice.
Autorzy:
Komleva PD; Department of Psychoneuropharmacology, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Alhalabi G; Department of Genetic Collections of Neural Disorders, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Izyurov AE; Department of Genetics of Industrial Microorganisms, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Khotskin NV; Department of Genetic Collections of Neural Disorders, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Kulikov AV; Department of Genetic Collections of Neural Disorders, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
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Źródło:
Biomolecules [Biomolecules] 2023 Jun 08; Vol. 13 (6). Date of Electronic Publication: 2023 Jun 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain*/metabolism
Depression*/etiology
Depression*/genetics
Depression*/metabolism
Obesity*/etiology
Obesity*/genetics
Obesity*/metabolism
Serotonin*/genetics
Serotonin*/metabolism
Tryptophan Hydroxylase*/genetics
Tryptophan Hydroxylase*/metabolism
Melanocortins*/genetics
Melanocortins*/metabolism
Animals ; Mice ; Mutation ; Swimming
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses Cell Reprogramming into Pluripotent State.
Autorzy:
Sinenko SA; Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064 St. Petersburg, Russia.
Kuzmin AA; Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064 St. Petersburg, Russia.
Skvortsova EV; Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064 St. Petersburg, Russia.
Ponomartsev SV; Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064 St. Petersburg, Russia.
Efimova EV; Institute of Translational Biomedicine, St-Petersburg State University, 7-9 Universitetskaya Emb, 199034 St. Petersburg, Russia.
Bader M; Max-Delbruck Center for Molecular Medicine, 13125 Berlin-Buch, Germany.
Alenina N; Max-Delbruck Center for Molecular Medicine, 13125 Berlin-Buch, Germany.
Tomilin AN; Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave. 4, 194064 St. Petersburg, Russia.; Institute of Translational Biomedicine, St-Petersburg State University, 7-9 Universitetskaya Emb, 199034 St. Petersburg, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 02; Vol. 24 (5). Date of Electronic Publication: 2023 Mar 02.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Reprogramming*
Serotonin*/biosynthesis
Tryptophan Hydroxylase*/metabolism
Pluripotent Stem Cells*
Animals ; Mice ; Fibroblasts/metabolism ; Tryptophan/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Peripheral Serotonin Deficiency Affects Anxiety-like Behavior and the Molecular Response to an Acute Challenge in Rats.
Autorzy:
Sbrini G; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
Hanswijk SI; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, 6525 EN Nijmegen, The Netherlands.
Brivio P; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
Middelman A; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, 6525 EN Nijmegen, The Netherlands.
Bader M; Max-Delbrück-Center for Molecular Medicine (MDC), 13125 Berlin, Germany.; Charite-University Medicine, 10117 Berlin, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, 10115 Berlin, Germany.; Institute for Biology, University of Lübeck, 23562 Lubeck, Germany.
Fumagalli F; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
Alenina N; Max-Delbrück-Center for Molecular Medicine (MDC), 13125 Berlin, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, 10115 Berlin, Germany.
Homberg JR; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, 6525 EN Nijmegen, The Netherlands.
Calabrese F; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Apr 29; Vol. 23 (9). Date of Electronic Publication: 2022 Apr 29.
Typ publikacji:
Journal Article
MeSH Terms:
Serotonin*/genetics
Serotonin*/metabolism
Tryptophan Hydroxylase*/genetics
Tryptophan Hydroxylase*/metabolism
Animals ; Anxiety/genetics ; Anxiety/metabolism ; Brain/metabolism ; Protein Isoforms/metabolism ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tph2 Gene Expression Defines Ethanol Drinking Behavior in Mice.
Autorzy:
Zaniewska M; Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany.; Laboratory of Pharmacology and Brain Biostructure, Department of Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 31-343 Kraków, Poland.
Mosienko V; Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Bader M; Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany.; Institute for Biology, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.; Charité University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin, Germany.
Alenina N; Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin, Germany.
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Źródło:
Cells [Cells] 2022 Mar 03; Vol. 11 (5). Date of Electronic Publication: 2022 Mar 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Serotonin*/metabolism
Tryptophan Hydroxylase*/genetics
Tryptophan Hydroxylase*/metabolism
Animals ; Drinking Behavior ; Ethanol/pharmacology ; Gene Expression ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Predation Stress Causes Excessive Aggression in Female Mice with Partial Genetic Inactivation of Tryptophan Hydroxylase-2: Evidence for Altered Myelination-Related Processes.
Autorzy:
Svirin E; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, 6200 MD Maastricht, The Netherlands.; Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, 97080 Würzburg, Germany.; Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315 Moscow, Russia.
Veniaminova E; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine and Department of Normal Physiology, Sechenov University, 119991 Moscow, Russia.
Costa-Nunes JP; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine and Department of Normal Physiology, Sechenov University, 119991 Moscow, Russia.; Institute of Molecular Medicine, New University of Lisbon, 1649-028 Lisbon, Portugal.
Gorlova A; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine and Department of Normal Physiology, Sechenov University, 119991 Moscow, Russia.
Umriukhin A; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine and Department of Normal Physiology, Sechenov University, 119991 Moscow, Russia.
Kalueff AV; Neuroscience Program, Sirius University, 354340 Sochi, Russia.; Moscow Institute of Physics and Technology, School of Biological and Medical Physics, 141701 Dolgoprudny, Russia.; Institute of Natural Sciences, Ural Federal University, 620002 Yekaterinburg, Russia.
Proshin A; P.K. Anokhin Research Institute of Normal Physiology, 125315 Moscow, Russia.
Anthony DC; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine and Department of Normal Physiology, Sechenov University, 119991 Moscow, Russia.; Department of Pharmacology, Oxford University, Oxford OX1 3QT, UK.
Nedorubov A; Institute of Translational Medicine and Biotechnology, Sechenov University, 119991 Moscow, Russia.
Tse ACK; Li Ka Shing Faculty of Medicine, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Walitza S; Department for Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, 8032 Zurich, Switzerland.
Lim LW; Li Ka Shing Faculty of Medicine, School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Lesch KP; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, 6200 MD Maastricht, The Netherlands.; Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, 97080 Würzburg, Germany.; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine and Department of Normal Physiology, Sechenov University, 119991 Moscow, Russia.
Strekalova T; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, 6200 MD Maastricht, The Netherlands.; Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315 Moscow, Russia.; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine and Department of Normal Physiology, Sechenov University, 119991 Moscow, Russia.
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Źródło:
Cells [Cells] 2022 Mar 18; Vol. 11 (6). Date of Electronic Publication: 2022 Mar 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Serotonin*/metabolism
Tryptophan Hydroxylase/*metabolism
Aggression/physiology ; Animals ; Female ; Glycogen Synthase Kinase 3 beta ; Male ; Mice ; Predatory Behavior ; Rats ; Tryptophan Hydroxylase/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tryptophan Hydroxylase 2 Deficiency Modifies the Effects of Fluoxetine and Pargyline on the Behavior, 5-HT- and BDNF-Systems in the Brain of Zebrafish ( Danio rerio ).
Autorzy:
Evsiukova VS; Department of Psychoneuropharmacology, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Bazovkina D; Department of Behavioral Neurogenomics, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Bazhenova E; Department of Genetic Collections of Neural Disorders, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Kulikova EA; Department of Psychoneuropharmacology, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Kulikov AV; Department of Genetic Collections of Neural Disorders, Federal Research Center Institute of Cytology and Genetic Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 27; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 27.
Typ publikacji:
Journal Article
MeSH Terms:
Behavior, Animal/*drug effects
Brain/*drug effects
Brain-Derived Neurotrophic Factor/*metabolism
Fluoxetine/*pharmacology
Pargyline/*pharmacology
Serotonin/*metabolism
Tryptophan Hydroxylase/*deficiency
Zebrafish Proteins/*deficiency
Animals ; Antidepressive Agents/pharmacology ; Brain/enzymology ; Brain/metabolism ; Disease Models, Animal ; Monoamine Oxidase Inhibitors/pharmacology ; Selective Serotonin Reuptake Inhibitors/pharmacology ; Tryptophan Hydroxylase/metabolism ; Zebrafish ; Zebrafish Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
TPH1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients.
Autorzy:
Snarska J; Department of General Surgery, Faculty of Medical Sciences, University of Warmia and Mazury, Olsztyn, Poland.
Fiedorowicz E; Department of Biochemistry, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Rozmus D; Department of Biochemistry, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Wroński K; General and Colorectal Surgery Clinic, University Clinical Hospital of the Military Medical Academy - Central Veterans Hospital in Lodz, Lodz, Poland.
Latacz M; Department of Biochemistry, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Kordulewska N; Department of Biochemistry, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Płomiński J; Department and Clinic of Orthopaedics and Traumatology, Collegium Medicum, University of Warmia and Mazury, 10-719, Olsztyn, Poland.
Grzybowski R; Department and Clinic of Orthopaedics and Traumatology, Collegium Medicum, University of Warmia and Mazury, 10-719, Olsztyn, Poland.
Savelkoul HFJ; Cell Biology and Immunology Group, Department of Animal Sciences, Wageningen University and Research, Wageningen, Netherlands.
Kostyra E; Department of Biochemistry, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Cieślińska A; Department of Biochemistry, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland. .
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Źródło:
BMC gastroenterology [BMC Gastroenterol] 2021 Nov 12; Vol. 21 (1), pp. 426. Date of Electronic Publication: 2021 Nov 12.
Typ publikacji:
Journal Article
MeSH Terms:
Pancreatitis*/genetics
Tryptophan Hydroxylase*/genetics
Serotonin/*blood
Acute Disease ; Genotype ; Humans ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Ahi1 regulates serotonin production by the GR/ERβ/TPH2 pathway involving sexual differences in depressive behaviors.
Autorzy:
Wang B; Department of Fetology, the First Affiliated Hospital of Soochow University, Suzhou, 215004, People's Republic of China.; Institute of Neuroscience, Soochow University, Suzhou, 215123, People's Republic of China.
Shi H; Institute of Neuroscience, Soochow University, Suzhou, 215123, People's Republic of China.
Ren L; Institute of Neuroscience, Soochow University, Suzhou, 215123, People's Republic of China.
Miao Z; Institute of Neuroscience, Soochow University, Suzhou, 215123, People's Republic of China.
Wan B; Institute of Neuroscience, Soochow University, Suzhou, 215123, People's Republic of China.
Yang H; Department of Fetology, the First Affiliated Hospital of Soochow University, Suzhou, 215004, People's Republic of China.
Fan X; Department of Developmental Neuropsychology, School of Psychology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Gustafsson JA; Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden.; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.
Sun M; Department of Fetology, the First Affiliated Hospital of Soochow University, Suzhou, 215004, People's Republic of China. .
Xu X; Institute of Neuroscience, Soochow University, Suzhou, 215123, People's Republic of China. .; Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, 215004, People's Republic of China. .; Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, 215123, Jiangsu, People's Republic of China. .; Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, People's Republic of China. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2022 May 28; Vol. 20 (1), pp. 74. Date of Electronic Publication: 2022 May 28.
Typ publikacji:
Journal Article; Video-Audio Media; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, Glucocorticoid*/metabolism
Serotonin*
Adaptor Proteins, Vesicular Transport/metabolism ; Animals ; Brain/metabolism ; Estrogen Receptor beta/metabolism ; Female ; Male ; Mice ; Mice, Knockout ; Tryptophan Hydroxylase/genetics ; Tryptophan Hydroxylase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Serotonin deficiency induced after brain maturation rescues consequences of early life adversity.
Autorzy:
Aboagye B; Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, Center of Mental Health, University of Würzburg, Margarete-Höppel-Platz 1, 97080, Würzburg, Germany.; Department of Biomedical and Forensic Science, School of Biological Sciences, University of Cape Coast, Cape Coast, Ghana.
Weber T; Department of Molecular Biology, Central Institute of Mental Health, Medical Faculty Mannheim , Heidelberg University, Mannheim, Germany.; MEDIAN Clinic Wilhelmsheim, Oppenweiler, Germany.
Merdian HL; School of Psychology, University of Lincoln, Lincoln, UK.
Bartsch D; Department of Molecular Biology, Central Institute of Mental Health, Medical Faculty Mannheim , Heidelberg University, Mannheim, Germany.
Lesch KP; Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, Center of Mental Health, University of Würzburg, Margarete-Höppel-Platz 1, 97080, Würzburg, Germany. .; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russia. .; Department of Psychiatry and Psychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands. .
Waider J; Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, Center of Mental Health, University of Würzburg, Margarete-Höppel-Platz 1, 97080, Würzburg, Germany. Waider_.
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Źródło:
Scientific reports [Sci Rep] 2021 Mar 08; Vol. 11 (1), pp. 5368. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain/*growth & development
Serotonin/*metabolism
Tryptophan Hydroxylase/*metabolism
Animals ; Emotions ; Male ; Maternal Deprivation ; Mice ; Mice, Knockout ; Serotonin/genetics ; Tryptophan Hydroxylase/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis.
Autorzy:
Park S; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Kim Y; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Lee J; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Lee JY; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Kim H; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Lee S; Department of School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Oh CM; Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 28; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 28.
Typ publikacji:
Journal Article
MeSH Terms:
Metabolome*
Adipose Tissue/*metabolism
Brain/*metabolism
Intestines/*physiology
Serotonin/*metabolism
Tryptophan Hydroxylase/*metabolism
Homeostasis ; Humans ; Systems Biology ; Transcriptome ; Tryptophan Hydroxylase/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Construction of cell factory capable of efficiently converting L-tryptophan into 5-hydroxytryptamine.
Autorzy:
Wang Y; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Chen X; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Chen Q; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Zhou N; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Wang X; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Zhang A; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Chen K; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China. .; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China. .
Ouyang P; State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, 211816, China.; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
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Źródło:
Microbial cell factories [Microb Cell Fact] 2022 Mar 24; Vol. 21 (1), pp. 47. Date of Electronic Publication: 2022 Mar 24.
Typ publikacji:
Journal Article
MeSH Terms:
Serotonin*/metabolism
Tryptophan*/metabolism
5-Hydroxytryptophan/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Tryptophan Hydroxylase/genetics ; Tryptophan Hydroxylase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Enduring Effects of Conditional Brain Serotonin Knockdown, Followed by Recovery, on Adult Rat Neurogenesis and Behavior.
Autorzy:
Sidorova M; School of Life Sciences, Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia.; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
Kronenberg G; Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatrische Universitätsklinik, 8032 Zürich, Switzerland.; Department of Psychiatry and Psychotherapy, Charité University Medicine, 10117 Berlin, Germany.
Matthes S; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
Petermann M; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.; Department of Clinical Pharmacy and Pharmacotherapy, Institute of Pharmacy, Martin Luther University, 06120 Halle, Germany.
Hellweg R; Department of Psychiatry and Psychotherapy, Charité University Medicine, 10117 Berlin, Germany.
Tuchina O; School of Life Sciences, Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia.
Bader M; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
Alenina N; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.; Institute of Translational Biomedicine, St. Petersburg State University, 199034 St. Petersburg, Russia.
Klempin F; School of Life Sciences, Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia.; Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité University Medicine, 10117 Berlin, Germany.
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Źródło:
Cells [Cells] 2021 Nov 19; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Behavior, Animal*
Gene Knockdown Techniques*
Neurogenesis*
Aging/*physiology
Serotonin/*metabolism
Animals ; Cell Count ; Cell Proliferation ; Dentate Gyrus/cytology ; Female ; Phenotype ; Prefrontal Cortex/metabolism ; Raphe Nuclei/metabolism ; Rats, Sprague-Dawley ; Tryptophan Hydroxylase/metabolism ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Age-Related Alterations in the Behavior and Serotonin-Related Gene mRNA Levels in the Brain of Males and Females of Short-Lived Turquoise Killifish ( Nothobranchius furzeri ).
Autorzy:
Evsiukova VS; Department of Psychoneuropharmacology, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Kulikova EA; Department of Psychoneuropharmacology, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Kulikov AV; Department of Genetic Collections of Neural Disorders, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
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Źródło:
Biomolecules [Biomolecules] 2021 Sep 28; Vol. 11 (10). Date of Electronic Publication: 2021 Sep 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aging/*genetics
Behavior, Animal/*physiology
Fundulidae/*genetics
Serotonin/*genetics
Aging/physiology ; Animals ; Brain/metabolism ; Female ; Fundulidae/physiology ; Gene Expression Regulation, Developmental/genetics ; Locomotion/genetics ; Locomotion/physiology ; Male ; Monoamine Oxidase/genetics ; RNA, Messenger/genetics ; Receptor, Serotonin, 5-HT1A/genetics ; Serotonin/metabolism ; Serotonin Plasma Membrane Transport Proteins/genetics ; Tryptophan Hydroxylase/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Administration of a Probiotic Mixture Ameliorates Cisplatin-Induced Mucositis and Pica by Regulating 5-HT in Rats.
Autorzy:
Wu Y; Department of Medical Oncology, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
Wu J; Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Lin Z; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Wang Q; Liaoning CapitalBio Technology Co., Ltd., Dalian, China.
Li Y; Department of Medical Oncology, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
Wang A; Department of Medical Oncology, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
Shan X; Department of Medical Oncology, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
Liu J; Department of Medical Oncology, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
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Źródło:
Journal of immunology research [J Immunol Res] 2021 Sep 14; Vol. 2021, pp. 9321196. Date of Electronic Publication: 2021 Sep 14 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Mucositis/*prevention & control
Pica/*prevention & control
Probiotics/*pharmacology
Serotonin/*metabolism
Animals ; Cell Line, Tumor ; Cisplatin ; Cytokines/metabolism ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/genetics ; Gene Expression Regulation/drug effects ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; Male ; Malondialdehyde/metabolism ; Mucin-2/genetics ; Mucin-2/metabolism ; Mucositis/chemically induced ; Mucositis/genetics ; Pica/chemically induced ; Pica/genetics ; Probiotics/administration & dosage ; Rats, Sprague-Dawley ; Serotonin/blood ; Serotonin Plasma Membrane Transport Proteins/genetics ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Time Factors ; Tryptophan Hydroxylase/genetics ; Tryptophan Hydroxylase/metabolism ; Rats
Czasopismo naukowe
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Tytuł:
Single or combined ablation of peripheral serotonin and p21 limit adipose tissue expansion and metabolic alterations in early adulthood in mice fed a normocaloric diet.
Autorzy:
Saponara E; Department of Visceral and Transplantation Surgery, Swiss Hepato-Pancreato-Biliary Center, University Hospital Zurich, Zurich, Switzerland.
Chen R; Department of Visceral and Transplantation Surgery, Swiss Hepato-Pancreato-Biliary Center, University Hospital Zurich, Zurich, Switzerland.
Reding T; Department of Visceral and Transplantation Surgery, Swiss Hepato-Pancreato-Biliary Center, University Hospital Zurich, Zurich, Switzerland.
Zuellig R; Division of Endocrinology, Diabetes & Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland.
Henstridge DC; School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, Australia.
Graf R; Department of Visceral and Transplantation Surgery, Swiss Hepato-Pancreato-Biliary Center, University Hospital Zurich, Zurich, Switzerland.; Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland.
Sonda S; Department of Visceral and Transplantation Surgery, Swiss Hepato-Pancreato-Biliary Center, University Hospital Zurich, Zurich, Switzerland.; School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, Australia.; Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland.
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Źródło:
PloS one [PLoS One] 2021 Aug 11; Vol. 16 (8), pp. e0255687. Date of Electronic Publication: 2021 Aug 11 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Deletion*
Adipose Tissue/*metabolism
Cyclin-Dependent Kinase Inhibitor p21/*metabolism
Diet, Healthy/*methods
Obesity/*metabolism
Serotonin/*biosynthesis
Signal Transduction/*genetics
Adipocytes/pathology ; Animals ; Cell Size ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Diet, High-Fat ; Glucose/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Obesity/genetics ; Tryptophan Hydroxylase/genetics ; Tryptophan Hydroxylase/metabolism ; Weight Gain/genetics
Czasopismo naukowe
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Tytuł:
The Role of Dorsal Raphe Serotonin Neurons in the Balance between Reward and Aversion.
Autorzy:
Nagai Y; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Takayama K; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Nishitani N; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.; Department of Neuropharmacology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15 W7 Kita-ku, Sapporo 060-8638, Japan.
Andoh C; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Koda M; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Shirakawa H; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Nakagawa T; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Nagayasu K; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Yamanaka A; Department of Neuroscience II, Research Institute of Environmental Medicine (RIEM), Nagoya University, Nagoya 464-8601, Japan.
Kaneko S; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Mar 21; Vol. 21 (6). Date of Electronic Publication: 2020 Mar 21.
Typ publikacji:
Journal Article
MeSH Terms:
Dorsal Raphe Nucleus/*physiology
Neurons/*physiology
Serotonin/*metabolism
Tryptophan Hydroxylase/*metabolism
Ventral Tegmental Area/*physiology
Animals ; Basal Forebrain/metabolism ; Basal Forebrain/physiology ; Behavior Rating Scale ; Central Amygdaloid Nucleus/metabolism ; Central Amygdaloid Nucleus/physiology ; Dependovirus/genetics ; Dorsal Raphe Nucleus/metabolism ; Enhancer Elements, Genetic ; Genetic Vectors ; Hypothalamic Area, Lateral/metabolism ; Hypothalamic Area, Lateral/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons/metabolism ; Nucleus Accumbens/metabolism ; Nucleus Accumbens/physiology ; Optogenetics ; Promoter Regions, Genetic ; Reward ; Serotonin/physiology ; Tryptophan Hydroxylase/genetics ; Ventral Tegmental Area/metabolism
Czasopismo naukowe
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Tytuł:
Fluoxetine-induced hepatic lipid accumulation is linked to elevated serotonin production.
Autorzy:
Ayyash A; Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON L8S 4K1, Canada.; Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Holloway AC; Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON L8S 4K1, Canada.; Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON L8S 4K1, Canada.
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Źródło:
Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2021 Sep; Vol. 99 (9), pp. 983-988. Date of Electronic Publication: 2021 Jan 30.
Typ publikacji:
Journal Article
MeSH Terms:
Fluoxetine/*pharmacology
Lipid Metabolism/*drug effects
Liver/*drug effects
Serotonin/*biosynthesis
Cell Line, Tumor ; Humans ; Liver/metabolism ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Tryptophan Hydroxylase/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Gastric Serotonin Biosynthesis and Its Functional Role in L-Arginine-Induced Gastric Proton Secretion.
Autorzy:
Holik AK; Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Schweiger K; Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Stoeger V; Christian Doppler Laboratory for Bioactive Aroma Compounds, Faculty of Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Lieder B; Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.; Christian Doppler Laboratory for Bioactive Aroma Compounds, Faculty of Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Reiner A; Pathologisch-Bakteriologisches Institut, Sozialmedizinisches Zentrum Ost- Donauspital, Langobardenstraße 122, 1220 Vienna, Austria.
Zopun M; Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Hoi JK; Christian Doppler Laboratory for Bioactive Aroma Compounds, Faculty of Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Kretschy N; Department of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Somoza MM; Department of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.; Food Chemistry and Molecular Sensory Science, Technical University of Munich, Lise-Meitner-Straße 34, 85354 Freising, Germany.; Leibniz Institute for Food Systems Biology, Technical University of Munich, Lise-Meitner-Str. 34, 85345 Freising, Germany.
Kriwanek S; Chirurgische Abteilung, Sozialmedizinisches Zentrum Ost- Donauspital, Langobardenstraße 122, 1220 Vienna, Austria.
Pignitter M; Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Somoza V; Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.; Christian Doppler Laboratory for Bioactive Aroma Compounds, Faculty of Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.; Leibniz Institute for Food Systems Biology, Technical University of Munich, Lise-Meitner-Str. 34, 85345 Freising, Germany.; Nutritional Systems Biology, School of Life Sciences, Technical University of Munich, Lise-Meitner-Str. 34, 85345 Freising, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 May 30; Vol. 22 (11). Date of Electronic Publication: 2021 May 30.
Typ publikacji:
Journal Article
MeSH Terms:
Protons*
Arginine/*pharmacology
Gastric Acid/*metabolism
Parietal Cells, Gastric/*drug effects
Serotonin/*biosynthesis
Cell Line, Tumor ; Fenclonine/pharmacology ; Gene Expression ; Granisetron/pharmacology ; Humans ; Hydrogen-Ion Concentration ; Parietal Cells, Gastric/cytology ; Parietal Cells, Gastric/metabolism ; Protease Inhibitors/pharmacology ; Receptors, Serotonin, 5-HT3/genetics ; Receptors, Serotonin, 5-HT3/metabolism ; Serotonin Antagonists/pharmacology ; Stomach/cytology ; Stomach/drug effects ; Tissue Culture Techniques ; Tryptophan Hydroxylase/antagonists & inhibitors ; Tryptophan Hydroxylase/genetics ; Tryptophan Hydroxylase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival.
Autorzy:
Muzerelle A; INSERM, Institut du Fer À Moulin, Sorbonne Université UMR-S 1270, Paris, France.
Soiza-Reilly M; INSERM, Institut du Fer À Moulin, Sorbonne Université UMR-S 1270, Paris, France.; Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina.
Hainer C; Max-Delbrück Center for Molecular Medecine (MDC), Berlin-Buch, Germany.
Ruet PL; INSERM, Institut du Fer À Moulin, Sorbonne Université UMR-S 1270, Paris, France.
Lesch KP; Division of Molecular Psychiatry, Laboratory of Translational Neuroscience, Center of Mental Health, Department of Psychiatry, University of Würzburg, Würzburg, Germany.; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.; Department of Neuropsychology and Psychiatry, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands.
Bader M; Max-Delbrück Center for Molecular Medecine (MDC), Berlin-Buch, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site, Berlin, Germany.; Charite-University Medicine, Berlin, Germany.; Institute for Biology, University of Lübeck, Lübeck, Germany.
Alenina N; Max-Delbrück Center for Molecular Medecine (MDC), Berlin-Buch, Germany. .; German Center for Cardiovascular Research (DZHK), Partner Site, Berlin, Germany. .; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia. .; Institute of Cytology, Russian Academy of Science, St. Petersburg, Russia. .
Scotto-Lomassese S; INSERM, Institut du Fer À Moulin, Sorbonne Université UMR-S 1270, Paris, France. .
Gaspar P; INSERM, Institut du Fer À Moulin, Sorbonne Université UMR-S 1270, Paris, France. .; INSERM U1127, Paris Brain Institute, 75013, Paris, France. .
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Źródło:
Scientific reports [Sci Rep] 2021 Mar 16; Vol. 11 (1), pp. 6004. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Maternal Behavior*
Synaptic Transmission*
Dorsal Raphe Nucleus/*metabolism
Serotonin/*metabolism
Animals ; Animals, Newborn ; Female ; Male ; Mice ; Mice, Knockout ; Serotonin/genetics ; Tryptophan Hydroxylase/deficiency ; Tryptophan Hydroxylase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Serotonin Pathway in Cancer.
Autorzy:
Balakrishna P; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
George S; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Hatoum H; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Mukherjee S; Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 28; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Antineoplastic Agents, Hormonal/*therapeutic use
Carcinoma, Neuroendocrine/*drug therapy
Cholangiocarcinoma/*drug therapy
Neovascularization, Pathologic/*drug therapy
Serotonin/*metabolism
Signal Transduction/*drug effects
Carcinoma, Neuroendocrine/blood supply ; Carcinoma, Neuroendocrine/metabolism ; Carcinoma, Neuroendocrine/pathology ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cholangiocarcinoma/blood supply ; Cholangiocarcinoma/metabolism ; Cholangiocarcinoma/pathology ; Gene Expression Regulation, Neoplastic ; Humans ; Molecular Targeted Therapy/methods ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/pathology ; Octreotide/therapeutic use ; Phenylalanine/analogs & derivatives ; Phenylalanine/therapeutic use ; Pyrimidines/therapeutic use ; Receptors, Serotonin/genetics ; Receptors, Serotonin/metabolism ; Serotonin Antagonists/therapeutic use ; Signal Transduction/genetics ; Tryptophan Hydroxylase/genetics ; Tryptophan Hydroxylase/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 1145

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