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Tytuł:
TP63 truncating mutation causes increased cell apoptosis and premature ovarian insufficiency by enhanced transcriptional activation of CLCA2.
Autorzy:
Fan Y; Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100006, China.
Chen S; Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100006, China.
Chu C; Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, China.
Yin X; Department of Traditional Chinese Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, China.
Jin J; Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, China.
Zhang L; Department of Gynaecology and Obstetrics, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Yan H; Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, China.
Cao Z; Department of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, China.
Liu R; Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100006, China.
Xin M; Department of Traditional Chinese Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, China. .
Li L; Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100006, China. .
Yin C; Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100006, China. .
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Źródło:
Journal of ovarian research [J Ovarian Res] 2024 Mar 25; Vol. 17 (1), pp. 67. Date of Electronic Publication: 2024 Mar 25.
Typ publikacji:
Journal Article
MeSH Terms:
Menopause, Premature*/genetics
Primary Ovarian Insufficiency*/genetics
Primary Ovarian Insufficiency*/metabolism
Transcription Factors*/genetics
Transcription Factors*/metabolism
Tumor Suppressor Proteins*/genetics
Female ; Humans ; Chloride Channels/genetics ; Chloride Channels/metabolism ; Exons ; Mutation ; Transcriptional Activation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of a complex intrachromosomal inverted insertion in the long arm of chromosome 9 as a cause of tuberous sclerosis complex in a Korean family.
Autorzy:
Ryu SW; 3billion, Inc, Seoul, South Korea.
Yoon JH; Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Kim DW; 3billion, Inc, Seoul, South Korea.
Han B; 3billion, Inc, Seoul, South Korea.
Han H; 3billion, Inc, Seoul, South Korea.
Han J; 3billion, Inc, Seoul, South Korea.
Lee H; 3billion, Inc, Seoul, South Korea.
Seo GH; 3billion, Inc, Seoul, South Korea.
Lee BH; Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Republic of Korea.
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Źródło:
Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2024 Mar; Vol. 12 (3), pp. e2330. Date of Electronic Publication: 2024 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Tumor Suppressor Proteins*/genetics
Tuberous Sclerosis*/genetics
Tuberous Sclerosis*/pathology
Humans ; Tuberous Sclerosis Complex 1 Protein/genetics ; Tuberous Sclerosis Complex 2 Protein/genetics ; Mutation ; Chromosomes, Human, Pair 9 ; Republic of Korea
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Time-resolved live-cell spectroscopy reveals EphA2 multimeric assembly.
Autorzy:
Shi X; Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Cleveland, OH 44109, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Lingerak R; Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Cleveland, OH 44109, USA.; Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Herting CJ; Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA 30322, USA.
Ge Y; Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Kim S; Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Cleveland, OH 44109, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Toth P; Department of Chemistry, University of Akron, Akron, OH 44325, USA.
Wang W; Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Cleveland, OH 44109, USA.
Brown BP; Department of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA.
Meiler J; Department of Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA.
Sossey-Alaoui K; Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Cleveland, OH 44109, USA.
Buck M; Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; Case Comprehensive Cancer Center, Cleveland, OH 44106, USA.
Himanen J; Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Hambardzumyan D; Departments Oncological Sciences and Neurosurgery, Tisch Cancer Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA.
Nikolov DB; Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Smith AW; Department of Chemistry, University of Akron, Akron, OH 44325, USA.
Wang B; Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Cleveland, OH 44109, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; Case Comprehensive Cancer Center, Cleveland, OH 44106, USA.; Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Dec; Vol. 382 (6674), pp. 1042-1050. Date of Electronic Publication: 2023 Nov 16.
Typ publikacji:
Journal Article
MeSH Terms:
Receptor, EphA2*/chemistry
Receptor, EphA2*/metabolism
Protein Multimerization*
Tumor Suppressor Proteins*/chemistry
Tumor Suppressor Proteins*/metabolism
Humans ; Ligands ; Neoplasm Invasiveness ; Phosphorylation ; Signal Transduction ; Spectrometry, Fluorescence
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of compound heterozygous deletion of the WWOX gene in WOREE syndrome.
Autorzy:
Dong XS; Prenatal Diagnosis Center, Zhongshan Boai Hospital Affiliated to Southern Medical University, Zhongshan, Guangdong, China.
Wen XJ; Reproductive Medicine Center, Zhongshan Boai Hospital Affiliated to Southern Medical University, Zhongshan, Guangdong, China.
Zhang S; Department of Pediatrics, Zhongshan Boai Hospital Affiliated to Southern Medical University, Zhongshan, Guangdong, China.
Wang DG; Prenatal Diagnosis Center, Zhongshan Boai Hospital Affiliated to Southern Medical University, Zhongshan, Guangdong, China.
Xiong Y; Prenatal Diagnosis Center, Zhongshan Boai Hospital Affiliated to Southern Medical University, Zhongshan, Guangdong, China.
Li ZM; Prenatal Diagnosis Center, Zhongshan Boai Hospital Affiliated to Southern Medical University, Zhongshan, Guangdong, China. .
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Źródło:
BMC medical genomics [BMC Med Genomics] 2023 Nov 16; Vol. 16 (1), pp. 291. Date of Electronic Publication: 2023 Nov 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tumor Suppressor Proteins*/genetics
Mothers*
Female ; Humans ; Child, Preschool ; WW Domain-Containing Oxidoreductase/genetics ; Syndrome ; Real-Time Polymerase Chain Reaction ; Gene Deletion
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Non-canonical functions of a mutant TSC2 protein in mitotic division.
Autorzy:
Chalkley ML; Department of Cell & Developmental Biology, School of Medicine Basic Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.
Mersfelder RB; Department of Cell & Developmental Biology, School of Medicine Basic Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.
Sundberg M; Rosamund Stone Zander Translational Neuroscience Center, Department of Neurology, Harvard Medical School, Boston, Massachusetts, United States of America.
Armstrong LC; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
Sahin M; Rosamund Stone Zander Translational Neuroscience Center, Department of Neurology, Harvard Medical School, Boston, Massachusetts, United States of America.
Ihrie RA; Department of Cell & Developmental Biology, School of Medicine Basic Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
Ess KC; Department of Cell & Developmental Biology, School of Medicine Basic Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
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Źródło:
PloS one [PLoS One] 2023 Oct 04; Vol. 18 (10), pp. e0292086. Date of Electronic Publication: 2023 Oct 04 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Signal Transduction*
Tumor Suppressor Proteins*/genetics
Tumor Suppressor Proteins*/metabolism
Humans ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mutant Proteins ; Tuberous Sclerosis Complex 2 Protein/genetics ; Tuberous Sclerosis Complex 2 Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer.
Autorzy:
Garcia-Vallicrosa C; Exosomes Laboratory and Metabolomics Platform, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Spain.
Falcon-Perez JM; Exosomes Laboratory and Metabolomics Platform, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas Y Digestivas (CIBERehd), 28029 Madrid, Spain.; IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain.
Royo F; Exosomes Laboratory and Metabolomics Platform, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas Y Digestivas (CIBERehd), 28029 Madrid, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 27; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Tumor Suppressor Proteins*/genetics
Urinary Bladder Neoplasms*/genetics
Male ; Humans ; RNA, Small Interfering/genetics ; Longevity ; Ceramides/metabolism ; Sphingosine N-Acyltransferase/genetics ; Sphingosine N-Acyltransferase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Single molecule studies characterize the kinetic mechanism of tetrameric p53 binding to different native response elements.
Autorzy:
Suwita JP; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.
Voong CK; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.
Ly E; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.
Goodrich JA; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.
Kugel JF; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.
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Źródło:
PloS one [PLoS One] 2023 Aug 15; Vol. 18 (8), pp. e0286193. Date of Electronic Publication: 2023 Aug 15 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Tumor Suppressor Protein p53*/genetics
Tumor Suppressor Proteins*/genetics
Humans ; Protein Binding ; Response Elements ; DNA/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prdx5 in the Regulation of Tuberous Sclerosis Complex Mutation-Induced Signaling Mechanisms.
Autorzy:
Bovari-Biri J; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pecs, 2. Rokus Str, H-7624 Pecs, Hungary.
Abdelwahab EMM; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pecs, 2. Rokus Str, H-7624 Pecs, Hungary.
Garai K; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pecs, 2. Rokus Str, H-7624 Pecs, Hungary.
Pongracz JE; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pecs, 2. Rokus Str, H-7624 Pecs, Hungary.
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Źródło:
Cells [Cells] 2023 Jun 24; Vol. 12 (13). Date of Electronic Publication: 2023 Jun 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tumor Suppressor Proteins*/metabolism
Tuberous Sclerosis*/drug therapy
Tuberous Sclerosis*/genetics
Tuberous Sclerosis*/metabolism
Humans ; Tuberous Sclerosis Complex 2 Protein ; Auranofin/pharmacology ; Sirolimus/pharmacology ; Antioxidants/therapeutic use ; Thioredoxin-Disulfide Reductase/genetics ; Mutation/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The ndrg2 Gene Regulates Hair Cell Morphogenesis and Auditory Function during Zebrafish Development.
Autorzy:
Wang C; Nantong Laboratory of Development and Diseases, School of Life Sciences, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China.
Wang X; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Nantong University, Nantong 226001, China.
Zheng H; School of Medicine, Nantong University, Nantong 226001, China.
Yao J; Nantong Laboratory of Development and Diseases, School of Life Sciences, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China.
Xiang Y; Nantong Laboratory of Development and Diseases, School of Life Sciences, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China.
Liu D; Nantong Laboratory of Development and Diseases, School of Life Sciences, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China.; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Nantong University, Nantong 226001, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 11; Vol. 24 (12). Date of Electronic Publication: 2023 Jun 11.
Typ publikacji:
Journal Article
MeSH Terms:
Deafness*/metabolism
Zebrafish*/genetics
Tumor Suppressor Proteins*/genetics
Zebrafish Proteins*/genetics
Animals ; Cell Proliferation ; Hair Cells, Auditory/metabolism ; Hearing ; Neurogenesis/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
STUB1 is acetylated by KAT5 and alleviates myocardial ischemia-reperfusion injury through LATS2-YAP-β-catenin axis.
Autorzy:
Liu C; Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, P.R. China.
Gui Z; Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, P.R. China.
An C; Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, P.R. China.
Sun F; Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, P.R. China.
Gao X; Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, P.R. China.
Ge S; Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, P.R. China. .
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Źródło:
Communications biology [Commun Biol] 2024 Apr 01; Vol. 7 (1), pp. 396. Date of Electronic Publication: 2024 Apr 01.
Typ publikacji:
Journal Article
MeSH Terms:
beta Catenin*/genetics
beta Catenin*/metabolism
Myocardial Reperfusion Injury*/metabolism
Humans ; Myocytes, Cardiac/metabolism ; Pyroptosis ; Ubiquitination ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Lysine Acetyltransferase 5/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Constitutional BRCA1 and MGMT Methylation Are Significant Risk Factors for Triple-Negative Breast Cancer and High-Grade Serous Ovarian Cancer in Saudi Women.
Autorzy:
Al-Moghrabi N; Cancer Epigenetics Section, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Al-Showimi M; Cancer Epigenetics Section, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Alqahtani A; Cancer Epigenetics Section, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Almalik O; Cancer Epigenetics Section, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Alhusaini H; Cancer Epigenetics Section, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Almalki G; Cancer Epigenetics Section, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Saad A; Cancer Epigenetics Section, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Alsunayi E; Cancer Epigenetics Section, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 07; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 07.
Typ publikacji:
Journal Article
MeSH Terms:
Triple Negative Breast Neoplasms*/epidemiology
Triple Negative Breast Neoplasms*/genetics
Breast Neoplasms*/metabolism
Ovarian Neoplasms*/epidemiology
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/pathology
Female ; Humans ; Saudi Arabia/epidemiology ; Promoter Regions, Genetic ; BRCA1 Protein/genetics ; BRCA1 Protein/metabolism ; DNA Methylation ; Risk Factors ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Genetic Predisposition to Disease ; DNA Modification Methylases/genetics ; DNA Modification Methylases/metabolism ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; DNA Repair Enzymes/genetics ; DNA Repair Enzymes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Insights into Hyperparathyroidism-Jaw Tumour Syndrome: From Endocrine Acumen to the Spectrum of CDC73 Gene and Parafibromin-Deficient Tumours.
Autorzy:
Gheorghe AM; PhD Doctoral School of 'Carol Davila', University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Sima OC; PhD Doctoral School of 'Carol Davila', University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Florescu AF; Endocrinology Department, 'Grigore T. Popa' University of Medicine and Pharmacy, 700111 Iasi, Romania.; Endocrinology Department, 'Sf. Spiridon' Emergency County Clinical Hospital, 700111 Iasi, Romania.
Ciuche A; Department 4-Cardio-Thoracic Pathology, Thoracic Surgery II Discipline, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Thoracic Surgery Department, 'Dr. Carol Davila' Central Emergency University Military Hospital, 010825 Bucharest, Romania.
Nistor C; Department 4-Cardio-Thoracic Pathology, Thoracic Surgery II Discipline, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Thoracic Surgery Department, 'Dr. Carol Davila' Central Emergency University Military Hospital, 010825 Bucharest, Romania.
Sandru F; Department of Dermatovenerology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Dermatovenerology, 'Elias' University Emergency Hospital, 011461 Bucharest, Romania.
Carsote M; Department of Endocrinology, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Clinical Endocrinology V, 'C.I. Parhon' National Institute of Endocrinology, 020021 Bucharest, Romania.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 15; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 15.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Parathyroid Neoplasms*/genetics
Parathyroid Neoplasms*/diagnosis
Jaw Neoplasms*/genetics
Hyperparathyroidism*/genetics
Hyperparathyroidism*/pathology
Fibroma*/genetics
Adenoma*
Male ; Female ; Humans ; Young Adult ; Adult ; Transcription Factors ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
SCR Disease Name:
Hyperparathyroidism 2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Efficacy of Selinexor in Relapsed/Refractory Multiple Myeloma (RRMM) Patients with del17p and Other High-Risk Abnormalities (A Retrospective Single-Center Study).
Autorzy:
Ehsan, Hamid (AUTHOR)
Robinson, Myra (AUTHOR)
Voorhees, Peter M. (AUTHOR)
Cassetta, Kristen (AUTHOR)
Borden, Shanice (AUTHOR)
Atrash, Shebli (AUTHOR)
Bhutani, Manisha (AUTHOR)
Varga, Cindy (AUTHOR)
Pineda-Roman, Mauricio (AUTHOR)
Friend, Reed (AUTHOR)
Paul, Barry A. (AUTHOR)
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Źródło:
Life (2075-1729). Mar2024, Vol. 14 Issue 3, p384. 9p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A tumor suppressor protein encoded by circKEAP1 inhibits osteosarcoma cell stemness and metastasis by promoting vimentin proteasome degradation and activating anti-tumor immunity.
Autorzy:
Zhang, Ying (AUTHOR)
Liu, Zhaoyong (AUTHOR)
Zhong, Zhigang (AUTHOR)
Ji, Yanchen (AUTHOR)
Guo, Huancheng (AUTHOR)
Wang, Weidong (AUTHOR)
Chen, Chuangzhen (AUTHOR)
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Źródło:
Journal of Experimental & Clinical Cancer Research (17569966). 2/21/2024, Vol. 43 Issue 1, p1-20. 20p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interplay between proteasome inhibitors and NF-κB pathway in leukemia and lymphoma: a comprehensive review on challenges ahead of proteasome inhibitors.
Autorzy:
Pakjoo, Mahdi (AUTHOR)
Ahmadi, Seyed Esmaeil (AUTHOR)
Zahedi, Mohammad (AUTHOR)
Jaafari, Niloofar (AUTHOR)
Khademi, Reyhane (AUTHOR)
Amini, Ali (AUTHOR)
Safa, Majid (AUTHOR)
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Źródło:
Cell Communication & Signaling. 2/8/2024, Vol. 22 Issue 1, p1-28. 28p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Analysis of patients with colorectal cancer shows a specific increase in serum anti-ING1 autoantibody levels.
Autorzy:
Arasawa T; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.; Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Hiwasa T; Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan. hiwasa_.; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-Ku, Chiba, 260-8670, Japan. hiwasa_.
Kagaya A; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.; Clinical Research Center, Chiba University Hospital, Chiba, 260-8677, Japan.
Maruyama T; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Uesato M; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Kano M; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Kobayashi S; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.; Department of Laboratory Medicine & Division of Clinical Genetics, Chiba University Hospital, Chiba, 260-8677, Japan.; Department of Medical Technology & Sciences, School of Health Sciences at Narita, International University of Health and Welfare, Chiba, 286-8686, Japan.
Takizawa H; Port Square Kashiwado Clinic, Kashiwado Memorial Foundation, Chiba, 260-0025, Japan.
Iwase K; Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Nomura F; Division of Clinical Genetics, Chiba Foundation for Health Promotion & Disease Prevention, Chiba, 261-0002, Japan.
Matsushita K; Department of Laboratory Medicine & Division of Clinical Genetics, Chiba University Hospital, Chiba, 260-8677, Japan.
Matsubara H; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
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Źródło:
BMC cancer [BMC Cancer] 2023 Apr 18; Vol. 23 (1), pp. 356. Date of Electronic Publication: 2023 Apr 18.
Typ publikacji:
Journal Article
MeSH Terms:
Tumor Suppressor Proteins*/genetics
Tumor Suppressor Proteins*/metabolism
Colorectal Neoplasms*/diagnosis
Humans ; Inhibitor of Growth Protein 1/metabolism ; Tumor Suppressor Protein p53/metabolism ; Nuclear Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Autoantibodies
Czasopismo naukowe
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Tytuł:
MGMT ProFWise: Unlocking a New Application for Combined Feature Selection and the Rank-Based Weighting Method to Link MGMT Methylation Status to Serum Protein Expression in Patients with Glioblastoma.
Autorzy:
Tasci E; Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, CRC, Bethesda, MD 20892, USA.
Shah Y; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.
Jagasia S; Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, CRC, Bethesda, MD 20892, USA.
Zhuge Y; Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, CRC, Bethesda, MD 20892, USA.
Shephard J; Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, CRC, Bethesda, MD 20892, USA.
Johnson MO; Department of Neurosurgery, Duke University, Durham, NC 27710, USA.; National Tele-Oncology, Veterans Health Administration, Durham, NC 27710, USA.
Elemento O; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.
Joyce T; Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, CRC, Bethesda, MD 20892, USA.
Chappidi S; Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, CRC, Bethesda, MD 20892, USA.
Cooley Zgela T; Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, CRC, Bethesda, MD 20892, USA.
Sproull M; Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, CRC, Bethesda, MD 20892, USA.
Mackey M; Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, CRC, Bethesda, MD 20892, USA.
Camphausen K; Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, CRC, Bethesda, MD 20892, USA.
Krauze AV; Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, CRC, Bethesda, MD 20892, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Apr 06; Vol. 25 (7). Date of Electronic Publication: 2024 Apr 06.
Typ publikacji:
Journal Article
MeSH Terms:
Glioblastoma*/genetics
Brain Neoplasms*/genetics
Humans ; Proteomics ; Temozolomide/therapeutic use ; Blood Proteins ; O(6)-Methylguanine-DNA Methyltransferase ; DNA Modification Methylases/genetics ; Tumor Suppressor Proteins/genetics ; DNA Repair Enzymes/genetics
Czasopismo naukowe
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Tytuł:
CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas.
Autorzy:
Tauziède-Espariat A; Department of Neuropathology, GHU Paris-Psychiatrie Et Neurosciences, Sainte-Anne Hospital, 1, Rue Cabanis, 75014, Paris, France. .
Nicaise Y; Department of Pathology, Toulouse University Hospital, Toulouse, France.; Cancer Research Center of Toulouse (CRCT), INSERM U1037, Toulouse, France.
Sievers P; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center DKFZ, German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
Sahm F; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center DKFZ, German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
von Deimling A; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center DKFZ, German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
Guillemot D; Paris-Sciences-Lettres, Curie Institute Research Center, INSERMU830, Paris, France.; Laboratory of Somatic Genetics, Curie Institute Hospital, Paris, France.
Pierron G; Paris-Sciences-Lettres, Curie Institute Research Center, INSERMU830, Paris, France.; Laboratory of Somatic Genetics, Curie Institute Hospital, Paris, France.
Duchesne M; Department of Pathology, Dupuytren University Hospital, Limoges, France.
Edjlali M; Radiology Department, AP-HP, Raymond Poincaré Hospital, 92380, Garches, France.
Dangouloff-Ros V; Pediatric Radiology Department, AP-HP, Hôpital Universitaire Necker-Enfants Malades, France, and Université de Paris, INSERM ERL UA10, INSERM U1163, Institut Imagine, F-75015, Paris, France.
Boddaert N; Pediatric Radiology Department, AP-HP, Hôpital Universitaire Necker-Enfants Malades, France, and Université de Paris, INSERM ERL UA10, INSERM U1163, Institut Imagine, F-75015, Paris, France.
Roux A; Department of Neurosurgery, GHU Paris-Psychiatrie Et Neurosciences, Sainte-Anne Hospital, Paris, France.
Dezamis E; Department of Neurosurgery, GHU Paris-Psychiatrie Et Neurosciences, Sainte-Anne Hospital, Paris, France.
Hasty L; Department of Neuropathology, GHU Paris-Psychiatrie Et Neurosciences, Sainte-Anne Hospital, 1, Rue Cabanis, 75014, Paris, France.
Lhermitte B; Department of Pathology, Strasbourg Hospital, Strasbourg, France.
Hirsch E; Department of Neurology, Strasbourg Hospital, Strasbourg, France.
Hirsch MPV; Radiology 2 Department, Strasbourg University Hospital, Hautepierre Hospital, Strasbourg, France.
Ardellier FD; Radiology 2 Department, Strasbourg University Hospital, Hautepierre Hospital, Strasbourg, France.; Engineering Science, Computer Science and Imaging Laboratory (ICube), Integrative Multimodal Imaging in Healthcare, UMR 7357, University of Strasbourg-CNRS, Strasbourg, France.
Karnoub MA; Department of Pediatric Neurosurgery, Lille University Hospital, 59000, Lille, France.
Csanyi M; Institute of Pathology, Centre de Biologie Pathologie, Lille University Hospital, 59000, Lille, France.
Maurage CA; Institute of Pathology, Centre de Biologie Pathologie, Lille University Hospital, 59000, Lille, France.
Mokhtari K; Sorbonne Université, AP-HP, Institut du Cerveau - Paris Brain Institute - ICM, Inserm,, CNRS, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Service de Neuropathologie, 75013, Paris, France.
Bielle F; Sorbonne Université, AP-HP, Institut du Cerveau - Paris Brain Institute - ICM, Inserm,, CNRS, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Service de Neuropathologie, 75013, Paris, France.
Rigau V; Department of Pathology, Gui de Chauliac Hospital, 34295, Montpellier, France.
Roujeau T; Department of Neurosurgery, Gui de Chauliac Hospital, 34295, Montpellier, France.
Abad M; Department of Pathology, Jean Minjoz Hospital, Besançon, France.
Klein S; Department of Pediatric Oncology, Jean Minjoz Hospital, Besançon, France.
Bernier M; Department of Pathology, Foch Hospital, Paris, France.
Horodyckid C; Department of Neurosurgery, Foch Hospital, Paris, France.
Adam C; Department of Pathology, Bicêtre Hospital, 94275, Le Kremlin-Bicêtre, France.
Brandal P; Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway.; Department of Oncology, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.
Niehusmann P; Devision of Cancer Medicine, Oslo University Hospital, Oslo, Norway.; Department of Pathology, Oslo University Hospital, Oslo, Norway.
Vannod-Michel Q; Radiology Department, Lille University Hospital, 59000, Lille, France.
Provost C; Department of Radiology, GHU-Paris-Psychiatrie Et Neurosciences, Hôpital Sainte Anne, 75014, Paris, France.
de Champfleur NM; Department of Radiology, Gui de Chauliac Hospital, 34295, Montpellier, France.
Nichelli L; Department of Neuroradiology, Sorbonne Université, AP-HP, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, 75013, Paris, France.
Métais A; Department of Neuropathology, GHU Paris-Psychiatrie Et Neurosciences, Sainte-Anne Hospital, 1, Rue Cabanis, 75014, Paris, France.; Institute of Psychiatry and Neuroscience of Paris (IPNP), Université Paris Cité, INSERM U1266, Imabrain Team, 75014, Paris, France.
Mariet C; Department of Neuropathology, GHU Paris-Psychiatrie Et Neurosciences, Sainte-Anne Hospital, 1, Rue Cabanis, 75014, Paris, France.
Chrétien F; Department of Neuropathology, GHU Paris-Psychiatrie Et Neurosciences, Sainte-Anne Hospital, 1, Rue Cabanis, 75014, Paris, France.; Institute of Psychiatry and Neuroscience of Paris (IPNP), Université Paris Cité, INSERM U1266, Imabrain Team, 75014, Paris, France.
Blauwblomme T; Department of Pediatric Neurosurgery, Necker Hospital, APHP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Beccaria K; Department of Pediatric Neurosurgery, Necker Hospital, APHP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Pallud J; Department of Neurosurgery, GHU Paris-Psychiatrie Et Neurosciences, Sainte-Anne Hospital, Paris, France.; Institute of Psychiatry and Neuroscience of Paris (IPNP), Université Paris Cité, INSERM U1266, Imabrain Team, 75014, Paris, France.
Puget S; Department of Neurosurgery, La Martinique Hospital, Fort-de-France, France.
Uro-Coste E; Department of Pathology, Toulouse University Hospital, Toulouse, France.; Cancer Research Center of Toulouse (CRCT), INSERM U1037, Toulouse, France.; Université Paul Sabatier, Toulouse III, Toulouse, France.
Varlet P; Department of Neuropathology, GHU Paris-Psychiatrie Et Neurosciences, Sainte-Anne Hospital, 1, Rue Cabanis, 75014, Paris, France.; Institute of Psychiatry and Neuroscience of Paris (IPNP), Université Paris Cité, INSERM U1266, Imabrain Team, 75014, Paris, France.
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Corporate Authors:
RENOCLIP-LOC
Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Apr 05; Vol. 12 (1), pp. 55. Date of Electronic Publication: 2024 Apr 05.
Typ publikacji:
Journal Article
MeSH Terms:
Brain Neoplasms*/genetics
Central Nervous System Neoplasms*/genetics
Ependymoma*/pathology
Glioma, Subependymal*
Supratentorial Neoplasms*/pathology
Child ; Humans ; Cell Cycle Proteins ; In Situ Hybridization, Fluorescence ; Transcription Factors/genetics ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
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Tytuł:
A systematic review of high impact CpG sites and regions for MGMT methylation in glioblastoma [A systematic review of MGMT methylation in GBM].
Autorzy:
Gibson D; Department of Neuro-Oncology, University of California, San Francisco, 400 Parnassus Ave, San Francisco, CA, USA.; Department of Bioinformatics, University of California, Los Angeles, Los Angeles, CA, USA.
Vo AH; Department of Neuro-Oncology, University of California, San Francisco, 400 Parnassus Ave, San Francisco, CA, USA. .
Lambing H; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Bhattacharya P; Department of Neuro-Oncology, University of California, San Francisco, 400 Parnassus Ave, San Francisco, CA, USA.
Tahir P; University of California, San Francisco Library, San Francisco, CA, USA.
Chehab FF; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Butowski N; Department of Neuro-Oncology, University of California, San Francisco, 400 Parnassus Ave, San Francisco, CA, USA.
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Źródło:
BMC neurology [BMC Neurol] 2024 Mar 23; Vol. 24 (1), pp. 103. Date of Electronic Publication: 2024 Mar 23.
Typ publikacji:
Systematic Review; Journal Article
MeSH Terms:
Brain Neoplasms*/genetics
Glioblastoma*/genetics
Glioma*/genetics
Humans ; DNA Methylation/genetics ; DNA Modification Methylases/genetics ; DNA Repair Enzymes/genetics ; Prognosis ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
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Wyświetlanie 1-20 z 14257

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