- Tytuł:
- Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer.
- Autorzy:
- Źródło:
- BMC cancer [BMC Cancer] 2018 Feb 05; Vol. 18 (1), pp. 136. Date of Electronic Publication: 2018 Feb 05.
- Typ publikacji:
- Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
- MeSH Terms:
-
Xenograft Model Antitumor Assays*
Azepines/*pharmacology
Cell Cycle Proteins/*antagonists & inhibitorsColorectal Neoplasms /*drug therapy
Protein Serine-Threonine Kinases/*antagonists & inhibitors
Proto-Oncogene Proteins/*antagonists & inhibitors
4-Aminobenzoic Acid/pharmacology ; Animals ; Antineoplastic Agents/pharmacology ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ;Colorectal Neoplasms /pathology ; Female ; G2 Phase Cell Cycle Checkpoints/drug effects ; HCT116 Cells ; HT29 Cells ; Humans ; Mice, Nude ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/metabolism ; Tumor Burden/drug effects ; Polo-Like Kinase 1
Czasopismo naukowe