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Wyświetlanie 1-20 z 57
Tytuł:
Pemafibrate suppresses NLRP3 inflammasome activation in the liver and heart in a novel mouse model of steatohepatitis-related cardiomyopathy.
Autorzy:
Kanno K; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Koseki M; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan. .
Chang J; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Saga A; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Inui H; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Okada T; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Tanaka K; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Asaji M; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Zhu Y; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Ide S; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Health Care Division, Health and Counselling Centre, Osaka University, Osaka, Japan.
Saito S; Division of Health Sciences, Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Osaka, Japan.
Higo T; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Okuzaki D; Genome Information Research Centre, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Ohama T; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Department of Dental Anaesthesiology, Osaka University Graduate School of Dentistry, Osaka, Japan.
Nishida M; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Health Care Division, Health and Counselling Centre, Osaka University, Osaka, Japan.
Kamada Y; Department of Advanced Metabolic Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan.
Ono M; Division of Innovative Medicine for Hepatobiliary and Pancreatology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Saibara T; Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan.
Yamashita S; Department of Cardiology, Rinku General Medical Centre, Osaka, Japan.
Sakata Y; Division of Cardiovascular Medicine, Department of Medicine, Osaka University Graduate School of Medicine, 2-2-B5 Yamadaoka, Suita, Osaka, 565-0871, Japan.
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Źródło:
Scientific reports [Sci Rep] 2022 Feb 22; Vol. 12 (1), pp. 2996. Date of Electronic Publication: 2022 Feb 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Benzoxazoles/*pharmacology
Butyrates/*pharmacology
Cardiomyopathies/*etiology
Cardiomyopathies/*metabolism
Inflammasomes/*metabolism
Liver/*metabolism
Myocardium/*metabolism
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Non-alcoholic Fatty Liver Disease/*etiology
Non-alcoholic Fatty Liver Disease/*metabolism
Animals ; Benzoxazoles/administration & dosage ; Butyrates/administration & dosage ; Cardiomyopathies/drug therapy ; Diet, High-Fat/adverse effects ; Dietary Carbohydrates/adverse effects ; Disease Models, Animal ; Gene Expression/drug effects ; Gene Expression/genetics ; Inflammasomes/genetics ; Male ; Mice, Inbred C57BL ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Non-alcoholic Fatty Liver Disease/drug therapy ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Role of Leaky Gut in Nonalcoholic Fatty Liver Disease: A Novel Therapeutic Target.
Autorzy:
Kessoku T; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.; Department of Palliative Medicine, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Kobayashi T; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Tanaka K; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.; Department of Palliative Medicine, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Yamamoto A; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Takahashi K; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Iwaki M; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.; Department of Palliative Medicine, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Ozaki A; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Kasai Y; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Nogami A; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Honda Y; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.; Department of Palliative Medicine, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Ogawa Y; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Kato S; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Imajo K; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Higurashi T; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Hosono K; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Yoneda M; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Usuda H; Department of Pharmacology, Shimane University Faculty of Medicine, 89-1 Enyacho, Izumo, Shimane 693-8501, Japan.
Wada K; Department of Pharmacology, Shimane University Faculty of Medicine, 89-1 Enyacho, Izumo, Shimane 693-8501, Japan.
Saito S; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Nakajima A; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 29; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 29.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Gastrointestinal Microbiome*
Gastrointestinal Tract*/microbiology
Gastrointestinal Tract*/pathology
Non-alcoholic Fatty Liver Disease*/microbiology
Non-alcoholic Fatty Liver Disease*/pathology
Dysbiosis/*microbiology
Endotoxins/*toxicity
Liver/*pathology
Animals ; Humans ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
High-Intensity Aerobic Exercise Improves Both Hepatic Fat Content and Stiffness in Sedentary Obese Men with Nonalcoholic Fatty Liver Disease.
Autorzy:
Oh S; The Center of Sports Medicine and Health Sciences, Tsukuba University Hospital, Ibaraki, 305-8576, Japan.; Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.; Japan Society for the Promotion of Science, Tokyo, 102-0083, Japan.
So R; Japan Society for the Promotion of Science, Tokyo, 102-0083, Japan.; National Institute of Occupational Safety and Health, Kanagawa, 214-8585, Japan.
Shida T; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, 305-8575, Japan.
Matsuo T; National Institute of Occupational Safety and Health, Kanagawa, 214-8585, Japan.
Kim B; Faculty of Sports Health Care, Inje University, Gyeongsangnamdo, 50834, Republic of Korea.
Akiyama K; Japan Society for the Promotion of Science, Tokyo, 102-0083, Japan.; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, 305-8575, Japan.
Isobe T; Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
Okamoto Y; Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
Tanaka K; Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, 305-8575, Japan.
Shoda J; The Center of Sports Medicine and Health Sciences, Tsukuba University Hospital, Ibaraki, 305-8576, Japan.; Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
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Źródło:
Scientific reports [Sci Rep] 2017 Feb 22; Vol. 7, pp. 43029. Date of Electronic Publication: 2017 Feb 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Exercise*
Lipid Metabolism/*physiology
Liver/*metabolism
Non-alcoholic Fatty Liver Disease/*pathology
Obesity/*pathology
Diffusion Tensor Imaging ; Fatty Acid Synthases/genetics ; Fatty Acid Synthases/metabolism ; Ferritins/metabolism ; Humans ; Intra-Abdominal Fat/metabolism ; Kupffer Cells/cytology ; Kupffer Cells/immunology ; Kupffer Cells/metabolism ; Leptin/metabolism ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/metabolism ; Liver/diagnostic imaging ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease/complications ; Obesity/complications ; Resistance Training ; Ultrasonography
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Transplantation of liver organoids in the omentum and kidney.
Autorzy:
Saito R; Department of Surgery, Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Ishii Y
Ito R
Nagatsuma K
Tanaka K
Saito M
Maehashi H
Nomoto H
Ohkawa K
Mano H
Aizawa M
Hano H
Yanaga K
Matsuura T
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Źródło:
Artificial organs [Artif Organs] 2011 Jan; Vol. 35 (1), pp. 80-3. Date of Electronic Publication: 2010 Oct 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Liver/*cytology
Organoids/*transplantation
Animals ; Bioreactors ; Cell Line ; Coculture Techniques ; Gene Expression ; Hepatocytes/cytology ; Kidney/cytology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Omentum/cytology ; Organoids/metabolism ; Tissue Scaffolds/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Estimation of postoperative fat absorption using the 13C mixed-triglyceride breath test in children with choledochal cyst.
Autorzy:
Suzuki M; Department of Pediatrics, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113 8421, Japan. />Tanaka K
Ohtani K
Kitamura K
Kudo T
Shoji H
Suzuki R
Shimizu T
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Źródło:
European journal of pediatrics [Eur J Pediatr] 2009 Jan; Vol. 168 (1), pp. 35-8. Date of Electronic Publication: 2008 Apr 01.
Typ publikacji:
Journal Article
MeSH Terms:
Choledochal Cyst/*diagnosis
Choledochal Cyst/*surgery
Dietary Fats/*metabolism
Liver/*metabolism
Triglycerides/*analysis
Anastomosis, Roux-en-Y ; Breath Tests ; Child ; Child, Preschool ; Choledochal Cyst/epidemiology ; Female ; Humans ; Jejunostomy ; Liver/diagnostic imaging ; Malabsorption Syndromes/diagnosis ; Malabsorption Syndromes/epidemiology ; Malabsorption Syndromes/metabolism ; Male ; Postoperative Period ; Severity of Illness Index ; Treatment Outcome ; Ultrasonography
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Pre-transplant treatment of hepatocellular carcinoma: assessment of tumor necrosis in explanted livers.
Autorzy:
Wong LL; Transplant Institute and Department of Surgery, St Francis Medical Center, Honolulu, HI, USA. />Tanaka K
Lau L
Komura S
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Źródło:
Clinical transplantation [Clin Transplant] 2004 Jun; Vol. 18 (3), pp. 227-34.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular/*therapy
Liver/*pathology
Liver Neoplasms/*therapy
Liver Transplantation/*methods
Preoperative Care/*methods
Adult ; Antineoplastic Agents/administration & dosage ; Catheter Ablation/methods ; Chemoembolization, Therapeutic/methods ; Cisplatin/administration & dosage ; Doxorubicin/administration & dosage ; Ethanol/administration & dosage ; Female ; Gels/administration & dosage ; Hepatectomy/methods ; Humans ; Injections, Intralesional ; Male ; Middle Aged ; Necrosis ; Retrospective Studies ; Treatment Outcome ; Waiting Lists
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Hepatic copper concentration in children undergoing living related liver transplantation due to Wilsonian fulminant hepatic failure.
Autorzy:
Komatsu H; Department of Pediatrics, National Defense Medical College, Tokorozawa City, Saitama, Japan. />Fujisawa T
Inui A
Sogo T
Sekine I
Kodama H
Uemoto S
Tanaka K
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Źródło:
Clinical transplantation [Clin Transplant] 2002 Jun; Vol. 16 (3), pp. 227-32.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Liver Transplantation*
Copper/*analysis
Hepatolenticular Degeneration/*complications
Liver/*chemistry
Liver Failure/*surgery
Adolescent ; Child ; Hepatolenticular Degeneration/metabolism ; Hepatolenticular Degeneration/surgery ; Humans ; Liver Failure/etiology ; Liver Failure/metabolism ; Living Donors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Structure determination of the constitutive 20S proteasome from bovine liver at 2.75 A resolution.
Autorzy:
Unno M; Institute for Protein Research, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan.
Mizushima T
Morimoto Y
Tomisugi Y
Tanaka K
Yasuoka N
Tsukihara T
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Źródło:
Journal of biochemistry [J Biochem] 2002 Feb; Vol. 131 (2), pp. 171-3.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cysteine Endopeptidases/*chemistry
Liver/*enzymology
Multienzyme Complexes/*chemistry
Animals ; Cattle ; Crystallography, X-Ray ; Electrochemistry ; Models, Molecular ; Proteasome Endopeptidase Complex ; Protein Conformation ; Protein Folding
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Purification and characterization of a membrane-bound sialidase from pig liver.
Autorzy:
Kobayashi T; Department of Clinical Pharmacology and Therapeutics, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Ito M
Ikeda K
Tanaka K
Saito M
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Źródło:
Journal of biochemistry [J Biochem] 2000 Apr; Vol. 127 (4), pp. 569-75.
Typ publikacji:
Journal Article
MeSH Terms:
Liver/*enzymology
Membrane Proteins/*metabolism
Neuraminidase/*metabolism
Animals ; Chromatography, Affinity ; Chromatography, High Pressure Liquid ; Electrophoresis, Polyacrylamide Gel ; Enzyme Inhibitors/pharmacology ; Hydrogen-Ion Concentration ; Membrane Proteins/isolation & purification ; Neuraminidase/antagonists & inhibitors ; Neuraminidase/isolation & purification ; Substrate Specificity ; Swine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Induction and inhibition of cytochrome P450 isoforms by imazalil, a food contaminant, in mouse small intestine and liver.
Autorzy:
Muto N; Department of Environmental Toxicology, Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Hirai H
Tanaka T
Itoh N
Tanaka K
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 1997 Dec; Vol. 27 (12), pp. 1215-23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cytochrome P-450 Enzyme Inhibitors*
Cytochrome P-450 Enzyme System/*biosynthesis
Food Contamination/*analysis
Fungicides, Industrial/*pharmacology
Imidazoles/*pharmacology
Intestine, Small/*enzymology
Isoenzymes/*antagonists & inhibitors
Isoenzymes/*biosynthesis
Liver/*enzymology
Animals ; Blotting, Western ; Enzyme Induction/drug effects ; Enzyme-Linked Immunosorbent Assay ; Intestine, Small/drug effects ; Liver/drug effects ; Male ; Mice ; Mice, Inbred Strains ; Microsomes/drug effects ; Microsomes/enzymology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 57

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