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Wyświetlanie 1-20 z 34
Tytuł:
Silibinin's regulation of proliferation and collagen gene expressions of rat pancreatic β-cells cultured on types I and V collagen involves β-catenin nuclear translocation.
Autorzy:
Yang J; a Wuya College of Innovation , Shenyang Pharmaceutical University , Shenyang , P.R. China.; b Department of Pharmacy , The Third People's Hospital of Chengdu , Chengdu , P.R. China.
Sun Y; a Wuya College of Innovation , Shenyang Pharmaceutical University , Shenyang , P.R. China.
Liu X; a Wuya College of Innovation , Shenyang Pharmaceutical University , Shenyang , P.R. China.
Xu F; a Wuya College of Innovation , Shenyang Pharmaceutical University , Shenyang , P.R. China.
Liu W; a Wuya College of Innovation , Shenyang Pharmaceutical University , Shenyang , P.R. China.
Hayashi T; a Wuya College of Innovation , Shenyang Pharmaceutical University , Shenyang , P.R. China.; c Department of Chemistry and Life science, School of Advanced Engineering , Kogakuin University , Hachioji , Japan.
Imamura Y; c Department of Chemistry and Life science, School of Advanced Engineering , Kogakuin University , Hachioji , Japan.
Mizuno K; d Nippi Research Institute of Biomatrix , Toride , Japan.
Hattori S; d Nippi Research Institute of Biomatrix , Toride , Japan.
Tanaka K; d Nippi Research Institute of Biomatrix , Toride , Japan.
Fujisaki H; d Nippi Research Institute of Biomatrix , Toride , Japan.
Tashiro SI; e Department of Medical Education and Primary Care , Kyoto Prefectural University of Medicine , Kyoto , Japan.
Onodera S; f Department of Clinical and Biomedical Sciences , Showa Pharmaceutical University , Tokyo , Japan.
Ikejima T; a Wuya College of Innovation , Shenyang Pharmaceutical University , Shenyang , P.R. China.; g Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development , Shenyang Pharmaceutical University , Shenyang , P.R. China.
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Źródło:
Connective tissue research [Connect Tissue Res] 2019 Sep; Vol. 60 (5), pp. 463-476. Date of Electronic Publication: 2019 May 14.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Nucleus/*metabolism
Collagen Type I/*pharmacology
Collagen Type V/*pharmacology
Gene Expression Regulation/*drug effects
Insulin-Secreting Cells/*metabolism
Silybin/*pharmacology
beta Catenin/*metabolism
Animals ; Cattle ; Cell Nucleus/drug effects ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Collagen Type I/genetics ; Collagen Type I/metabolism ; Collagen Type V/genetics ; Collagen Type V/metabolism ; Insulin-Secreting Cells/drug effects ; Protein Transport/drug effects ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Reactive oxygen species are responsible for the cell aggregation and production of pro-inflammatory mediators in phorbol ester (PMA)-treated U937 cells on gelatin-coated dishes through upregulation of autophagy.
Autorzy:
Zhao YL; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Zhang X; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Liu WW; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Yang YT; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Gao ZK; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Liu XL; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Liu W; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Hayashi T; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Yamato M; b Institute of Advanced Biomedical Engineering and Science , Tokyo Women's Medical University , Tokyo , Japan.
Fujisaki H; c Nippi Research Institute of Biomatrix , Toride, Ibaraki , Japan.
Hattori S; c Nippi Research Institute of Biomatrix , Toride, Ibaraki , Japan.
Mizuno K; c Nippi Research Institute of Biomatrix , Toride, Ibaraki , Japan.
Atsuzawa Y; c Nippi Research Institute of Biomatrix , Toride, Ibaraki , Japan.
Tashiro SI; d Department of Medical Education and Primary Care , Kyoto Prefectural University of Medicine , Kyoto , Japan.
Onodera S; e Department of Clinical and Pharmaceutical Sciences , Showa Pharmaceutical University , Tokyo , Japan.
Ikejima T; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
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Źródło:
Connective tissue research [Connect Tissue Res] 2019 Jul; Vol. 60 (4), pp. 323-334. Date of Electronic Publication: 2018 Dec 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy/*drug effects
Gelatin/*chemistry
Inflammation Mediators/*metabolism
Phorbol Esters/*pharmacology
Reactive Oxygen Species/*metabolism
Up-Regulation/*drug effects
Animals ; Cell Aggregation/drug effects ; Cell Differentiation/drug effects ; Dinoprostone/metabolism ; Humans ; Interleukin-1beta/metabolism ; Models, Biological ; Signal Transduction/drug effects ; Swine ; Tumor Necrosis Factor-alpha/metabolism ; U937 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differential levels of reactive oxygen species in murine preadipocyte 3T3-L1 cells cultured on type I collagen molecule-coated and gel-covered dishes exert opposite effects on NF-κB-mediated proliferation and migration.
Autorzy:
Liu X; a China-Japan Research Institute of Medical Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Long X; a China-Japan Research Institute of Medical Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Liu W; a China-Japan Research Institute of Medical Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Yao G; b School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education) , Shenyang Pharmaceutical University , Shenyang , China.
Zhao Y; a China-Japan Research Institute of Medical Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Hayashi T; a China-Japan Research Institute of Medical Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Hattori S; c Nippi Research Institute of Biomatrix , Ibaraki , Japan.
Fujisaki H; c Nippi Research Institute of Biomatrix , Ibaraki , Japan.
Ogura T; c Nippi Research Institute of Biomatrix , Ibaraki , Japan.
Tashiro SI; d Department of Medical Education and Primary Care , Kyoto Prefectural University of Medicine , Kyoto , Japan.
Onodera S; e Department of Clinical and Pharmaceutical Sciences , Showa Pharmaceutical University , Tokyo , Japan.
Yamato M; f Institute of Advanced Biomedical Engineering and Science , Tokyo Women's Medical University , Tokyo , Japan.
Ikejima T; a China-Japan Research Institute of Medical Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
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Źródło:
Free radical research [Free Radic Res] 2018 Sep; Vol. 52 (9), pp. 913-928. Date of Electronic Publication: 2018 Sep 28.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Movement/*drug effects
Cell Proliferation/*drug effects
Collagen Type I/*chemistry
Culture Media/*chemistry
3T3-L1 Cells ; Animals ; Collagen Type I/pharmacology ; Mice ; NF-kappa B/chemistry ; Reactive Oxygen Species/chemistry ; Reactive Oxygen Species/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Collagen gel protects L929 cells from TNFα-induced death by activating NF-κB.
Autorzy:
Wang HJ; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Li MQ; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Liu WW; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Hayashi T; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Fujisaki H; b Nippi Research Institute of Biomatrix, Nippi, Incorporated , Toride , Japan.
Hattori S; b Nippi Research Institute of Biomatrix, Nippi, Incorporated , Toride , Japan.
Tashiro SI; c Department of Medical Education & Primary Care , Kyoto Prefectural University of Medicine , Kyoto , Japan.
Onodera S; d Department of Clinical and Pharmaceutical Sciences , Showa Pharmaceutical University , Tokyo , Japan.
Ikejima T; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
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Źródło:
Connective tissue research [Connect Tissue Res] 2017 Sep; Vol. 58 (5), pp. 456-463. Date of Electronic Publication: 2016 Oct 20.
Typ publikacji:
Journal Article
MeSH Terms:
Collagen Type I*/chemistry
Collagen Type I*/pharmacology
Hydrogels*/chemistry
Hydrogels*/pharmacology
Apoptosis/*drug effects
Autophagy/*drug effects
NF-kappa B/*metabolism
Tumor Necrosis Factor-alpha/*pharmacology
Animals ; Cell Line ; Mice ; Proline/analogs & derivatives ; Proline/pharmacology ; Thiocarbamates/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Gelatin promotes murine fibrosarcoma L929 cell detachment and protects the cells from TNFα-induced cytotoxicity.
Autorzy:
Wang HJ; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Li MQ; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Liu W; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Yao GD; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Xia MY; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Hayashi T; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Fujisaki H; b Nippi Research Institute of Biomatrix, Nippi, Incorporated, Toride , Japan.
Hattori S; b Nippi Research Institute of Biomatrix, Nippi, Incorporated, Toride , Japan.
Tashiro S; c Department of Medical Education and Primary Care , Kyoto Prefectural University of Medicine , Kyoto , Japan.
Onodera S; d Department of Clinical and Pharmaceutical Sciences , Showa Pharmaceutical University , Tokyo , Japan.
Ikejima T; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
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Źródło:
Connective tissue research [Connect Tissue Res] 2016 Jul; Vol. 57 (4), pp. 262-9. Date of Electronic Publication: 2016 Mar 31.
Typ publikacji:
Journal Article
MeSH Terms:
Cytoprotection/*drug effects
Fibrosarcoma/*pathology
Gelatin/*pharmacology
Tumor Necrosis Factor-alpha/*pharmacology
Adenosine Triphosphate/metabolism ; Animals ; Autophagy/drug effects ; Cell Adhesion/drug effects ; Cell Aggregation/drug effects ; Cell Death/drug effects ; Cell Line, Tumor ; Mice ; Reactive Oxygen Species/metabolism ; Sus scrofa
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
p53-mediated autophagy adjustment is involved in the protection of silibinin against murine dermal inflammation and epidermal apoptosis induced by UVB irradiation.
Autorzy:
Wang Q; China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China.
Liu W
Zeng H
Xie X
Zang G
Ye Y
Tashiro S
Onodera S
Jiang S
Ikejima T
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Źródło:
Journal of Asian natural products research [J Asian Nat Prod Res] 2013; Vol. 15 (2), pp. 117-29. Date of Electronic Publication: 2013 Feb 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy/*radiation effects
Epidermis/*radiation effects
Inflammation/*metabolism
Silymarin/*pharmacology
Tumor Suppressor Protein p53/*metabolism
Animals ; Apoptosis/genetics ; Apoptosis/radiation effects ; Autophagy/genetics ; Epidermis/metabolism ; Epithelial Cells/metabolism ; Inflammation/genetics ; Male ; Mice ; Molecular Structure ; Silybin ; Silymarin/blood ; Silymarin/chemistry ; Skin Neoplasms/genetics ; Skin Neoplasms/metabolism ; Skin Neoplasms/prevention & control ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In vivo recovery effect of silibinin treatment on streptozotocin-induced diabetic mice is associated with the modulations of Sirt-1 expression and autophagy in pancreatic β-cell.
Autorzy:
Wang Q; China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Liu M
Liu WW
Hao WB
Tashiro S
Onodera S
Ikejima T
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Źródło:
Journal of Asian natural products research [J Asian Nat Prod Res] 2012; Vol. 14 (5), pp. 413-23. Date of Electronic Publication: 2012 Mar 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy/*drug effects
Diabetes Mellitus/*chemically induced
Insulin-Secreting Cells/*drug effects
Silymarin/*pharmacology
Sirtuin 1/*genetics
Streptozocin/*pharmacology
Animals ; Apoptosis/drug effects ; Diabetes Mellitus/metabolism ; Female ; Insulin-Secreting Cells/metabolism ; Male ; Mice ; Silybum marianum/chemistry ; Molecular Structure ; Silybin ; Silymarin/chemistry ; Sirtuin 1/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dual effects of silibinin treatment on autophagy-regulated dermal apoptosis retardation and epidermal apoptosis up-regulation in UVB-induced skin inflammation.
Autorzy:
Wang Q; China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Ye Y
Liu W
Jiang S
Tashiro S
Onodera S
Gu F
Wang Y
Ikejima T
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Źródło:
Journal of Asian natural products research [J Asian Nat Prod Res] 2012; Vol. 14 (7), pp. 688-99. Date of Electronic Publication: 2012 May 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy*
Skin*/immunology
Skin*/pathology
Skin*/radiation effects
Ultraviolet Rays*
Apoptosis/*drug effects
Silymarin/*pharmacology
Animals ; Blotting, Western ; Dermis/drug effects ; Epidermis/drug effects ; Female ; Male ; Mast Cells/drug effects ; Mice ; Silybum marianum/chemistry ; Molecular Structure ; Seeds/chemistry ; Silybin ; Silymarin/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
p38-NF-κB-promoted mitochondria-associated apoptosis and G2/M cell cycle arrest in norcantharidin-treated HeLa cells.
Autorzy:
Dong X; China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China.
Li JC
Jiang YY
Xia MY
Tashiro S
Onodera S
Ikejima T
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Źródło:
Journal of Asian natural products research [J Asian Nat Prod Res] 2012; Vol. 14 (11), pp. 1008-19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*drug effects
Bridged Bicyclo Compounds, Heterocyclic/*pharmacology
G2 Phase Cell Cycle Checkpoints/*drug effects
Mitochondria/*metabolism
NF-kappa B/*pharmacology
Pyrrolidines/*pharmacology
Thiocarbamates/*pharmacology
p38 Mitogen-Activated Protein Kinases/*metabolism
Bridged Bicyclo Compounds, Heterocyclic/chemistry ; Cell Cycle/drug effects ; HeLa Cells ; Humans ; Molecular Structure ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Silibinin induces protective superoxide generation in human breast cancer MCF-7 cells.
Autorzy:
Wang HJ; China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Jiang YY
Wei XF
Huang H
Tashiro S
Onodera S
Ikejima T
Pokaż więcej
Źródło:
Free radical research [Free Radic Res] 2010 Jan; Vol. 44 (1), pp. 90-100.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms/*metabolism
Superoxides/*metabolism
Antioxidants/pharmacology ; Breast Neoplasms/pathology ; Cell Death ; Cell Line, Tumor ; Cytoprotection/drug effects ; Drug Evaluation, Preclinical ; Feedback, Physiological/drug effects ; Feedback, Physiological/physiology ; Female ; Homeostasis/drug effects ; Humans ; Mitochondria/drug effects ; Mitochondria/metabolism ; Models, Biological ; Protein-Tyrosine Kinases/metabolism ; Reactive Oxygen Species/metabolism ; Silybin ; Silymarin/pharmacology ; Superoxides/pharmacology ; Up-Regulation/drug effects ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Oridonin induces human melanoma A375-S2 cell death partially through inhibiting insulin-like growth factor 1 receptor signaling.
Autorzy:
Wang HJ; China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, China.
Li D
Yang FY
Tashiro S
Onodera S
Ikejima T
Pokaż więcej
Źródło:
Journal of Asian natural products research [J Asian Nat Prod Res] 2008 Jul-Aug; Vol. 10 (7-8), pp. 787-98.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Death/*drug effects
Diterpenes, Kaurane/*chemistry
Diterpenes, Kaurane/*pharmacology
Receptor, IGF Type 1/*metabolism
Cell Line, Tumor ; Dose-Response Relationship, Drug ; Down-Regulation ; Enzyme Activation ; Gene Expression Regulation ; Humans ; Insulin-Like Growth Factor I/metabolism ; Molecular Structure ; Signal Transduction ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Nitric oxide activated by p38 and NF-kappaB facilitates apoptosis and cell cycle arrest under oxidative stress in evodiamine-treated human melanoma A375-S2 cells.
Autorzy:
Yang J; China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, PR, China.
Wu LJ
Tashiro S
Onodera S
Ikejima T
Pokaż więcej
Źródło:
Free radical research [Free Radic Res] 2008 Jan; Vol. 42 (1), pp. 1-11.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Cell Cycle/*drug effects
Melanoma/*drug therapy
NF-kappa B/*metabolism
Nitric Oxide/*metabolism
Oxidative Stress/*drug effects
Plant Extracts/*pharmacology
Quinazolines/*pharmacology
p38 Mitogen-Activated Protein Kinases/*metabolism
Antineoplastic Agents, Phytogenic/therapeutic use ; Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Enzyme Activation ; Feedback, Physiological ; Humans ; Imidazoles/pharmacology ; Melanoma/enzymology ; Melanoma/metabolism ; Melanoma/pathology ; Membrane Potential, Mitochondrial/drug effects ; NF-kappa B/antagonists & inhibitors ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide Synthase Type II/antagonists & inhibitors ; Nitric Oxide Synthase Type II/metabolism ; Plant Extracts/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Pyridines/pharmacology ; Pyrrolidines/pharmacology ; Quinazolines/therapeutic use ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Thiocarbamates/pharmacology ; Time Factors ; Tumor Suppressor Protein p53/metabolism ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 34

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