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Wyświetlanie 1-20 z 121
Tytuł:
Reactive oxygen species are responsible for the cell aggregation and production of pro-inflammatory mediators in phorbol ester (PMA)-treated U937 cells on gelatin-coated dishes through upregulation of autophagy.
Autorzy:
Zhao YL; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Zhang X; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Liu WW; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Yang YT; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Gao ZK; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Liu XL; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Liu W; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Hayashi T; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Yamato M; b Institute of Advanced Biomedical Engineering and Science , Tokyo Women's Medical University , Tokyo , Japan.
Fujisaki H; c Nippi Research Institute of Biomatrix , Toride, Ibaraki , Japan.
Hattori S; c Nippi Research Institute of Biomatrix , Toride, Ibaraki , Japan.
Mizuno K; c Nippi Research Institute of Biomatrix , Toride, Ibaraki , Japan.
Atsuzawa Y; c Nippi Research Institute of Biomatrix , Toride, Ibaraki , Japan.
Tashiro SI; d Department of Medical Education and Primary Care , Kyoto Prefectural University of Medicine , Kyoto , Japan.
Onodera S; e Department of Clinical and Pharmaceutical Sciences , Showa Pharmaceutical University , Tokyo , Japan.
Ikejima T; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
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Źródło:
Connective tissue research [Connect Tissue Res] 2019 Jul; Vol. 60 (4), pp. 323-334. Date of Electronic Publication: 2018 Dec 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy/*drug effects
Gelatin/*chemistry
Inflammation Mediators/*metabolism
Phorbol Esters/*pharmacology
Reactive Oxygen Species/*metabolism
Up-Regulation/*drug effects
Animals ; Cell Aggregation/drug effects ; Cell Differentiation/drug effects ; Dinoprostone/metabolism ; Humans ; Interleukin-1beta/metabolism ; Models, Biological ; Signal Transduction/drug effects ; Swine ; Tumor Necrosis Factor-alpha/metabolism ; U937 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Collagen gel protects L929 cells from TNFα-induced death by activating NF-κB.
Autorzy:
Wang HJ; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Li MQ; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Liu WW; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Hayashi T; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Fujisaki H; b Nippi Research Institute of Biomatrix, Nippi, Incorporated , Toride , Japan.
Hattori S; b Nippi Research Institute of Biomatrix, Nippi, Incorporated , Toride , Japan.
Tashiro SI; c Department of Medical Education & Primary Care , Kyoto Prefectural University of Medicine , Kyoto , Japan.
Onodera S; d Department of Clinical and Pharmaceutical Sciences , Showa Pharmaceutical University , Tokyo , Japan.
Ikejima T; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
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Źródło:
Connective tissue research [Connect Tissue Res] 2017 Sep; Vol. 58 (5), pp. 456-463. Date of Electronic Publication: 2016 Oct 20.
Typ publikacji:
Journal Article
MeSH Terms:
Collagen Type I*/chemistry
Collagen Type I*/pharmacology
Hydrogels*/chemistry
Hydrogels*/pharmacology
Apoptosis/*drug effects
Autophagy/*drug effects
NF-kappa B/*metabolism
Tumor Necrosis Factor-alpha/*pharmacology
Animals ; Cell Line ; Mice ; Proline/analogs & derivatives ; Proline/pharmacology ; Thiocarbamates/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
p53-mediated autophagy adjustment is involved in the protection of silibinin against murine dermal inflammation and epidermal apoptosis induced by UVB irradiation.
Autorzy:
Wang Q; China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China.
Liu W
Zeng H
Xie X
Zang G
Ye Y
Tashiro S
Onodera S
Jiang S
Ikejima T
Pokaż więcej
Źródło:
Journal of Asian natural products research [J Asian Nat Prod Res] 2013; Vol. 15 (2), pp. 117-29. Date of Electronic Publication: 2013 Feb 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy/*radiation effects
Epidermis/*radiation effects
Inflammation/*metabolism
Silymarin/*pharmacology
Tumor Suppressor Protein p53/*metabolism
Animals ; Apoptosis/genetics ; Apoptosis/radiation effects ; Autophagy/genetics ; Epidermis/metabolism ; Epithelial Cells/metabolism ; Inflammation/genetics ; Male ; Mice ; Molecular Structure ; Silybin ; Silymarin/blood ; Silymarin/chemistry ; Skin Neoplasms/genetics ; Skin Neoplasms/metabolism ; Skin Neoplasms/prevention & control ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Nitric oxide (•NO) generation but not ROS plays a major role in silibinin-induced autophagic and apoptotic death in human epidermoid carcinoma A431 cells.
Autorzy:
Yu Y; China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, P.R. China.
Fan SM
Yuan SJ
Tashiro S
Onodera S
Ikejima T
Pokaż więcej
Źródło:
Free radical research [Free Radic Res] 2012 Nov; Vol. 46 (11), pp. 1346-60. Date of Electronic Publication: 2012 Sep 05.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Autophagy/*drug effects
Carcinoma, Squamous Cell/*metabolism
Nitric Oxide/*metabolism
Reactive Oxygen Species/*metabolism
Silymarin/*pharmacology
Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Free Radicals/metabolism ; Humans ; Lipid Peroxidation/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Signal Transduction ; Silybin ; Silymarin/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Nitric oxide augments oridonin-induced efferocytosis by human histocytic lymphoma U937 cells via autophagy and the NF-κB-COX-2-IL-1β pathway.
Autorzy:
Zang L; China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University , 103 Wenhua Road, Shenyang , People's Republic of China.
He H
Ye Y
Liu W
Fan S
Tashiro S
Onodera S
Ikejima T
Pokaż więcej
Źródło:
Free radical research [Free Radic Res] 2012 Oct; Vol. 46 (10), pp. 1207-19. Date of Electronic Publication: 2012 Jul 04.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Autophagy/*drug effects
Cyclooxygenase 2/*metabolism
Diterpenes, Kaurane/*pharmacology
Interleukin-1beta/*metabolism
Lymphoma, Large B-Cell, Diffuse/*pathology
NF-kappa B/*metabolism
Nitric Oxide/*metabolism
Autophagy/physiology ; Cell Differentiation/drug effects ; Cell Differentiation/physiology ; Dose-Response Relationship, Drug ; Enzyme Activation/drug effects ; Humans ; Interleukin-1beta/biosynthesis ; Interleukin-1beta/genetics ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/metabolism ; NF-kappa B/genetics ; Nitric Oxide/biosynthesis ; Nitric Oxide/genetics ; Signal Transduction ; Transfection ; U937 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In vivo recovery effect of silibinin treatment on streptozotocin-induced diabetic mice is associated with the modulations of Sirt-1 expression and autophagy in pancreatic β-cell.
Autorzy:
Wang Q; China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Liu M
Liu WW
Hao WB
Tashiro S
Onodera S
Ikejima T
Pokaż więcej
Źródło:
Journal of Asian natural products research [J Asian Nat Prod Res] 2012; Vol. 14 (5), pp. 413-23. Date of Electronic Publication: 2012 Mar 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy/*drug effects
Diabetes Mellitus/*chemically induced
Insulin-Secreting Cells/*drug effects
Silymarin/*pharmacology
Sirtuin 1/*genetics
Streptozocin/*pharmacology
Animals ; Apoptosis/drug effects ; Diabetes Mellitus/metabolism ; Female ; Insulin-Secreting Cells/metabolism ; Male ; Mice ; Silybum marianum/chemistry ; Molecular Structure ; Silybin ; Silymarin/chemistry ; Sirtuin 1/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dual effects of silibinin treatment on autophagy-regulated dermal apoptosis retardation and epidermal apoptosis up-regulation in UVB-induced skin inflammation.
Autorzy:
Wang Q; China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Ye Y
Liu W
Jiang S
Tashiro S
Onodera S
Gu F
Wang Y
Ikejima T
Pokaż więcej
Źródło:
Journal of Asian natural products research [J Asian Nat Prod Res] 2012; Vol. 14 (7), pp. 688-99. Date of Electronic Publication: 2012 May 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy*
Skin*/immunology
Skin*/pathology
Skin*/radiation effects
Ultraviolet Rays*
Apoptosis/*drug effects
Silymarin/*pharmacology
Animals ; Blotting, Western ; Dermis/drug effects ; Epidermis/drug effects ; Female ; Male ; Mast Cells/drug effects ; Mice ; Silybum marianum/chemistry ; Molecular Structure ; Seeds/chemistry ; Silybin ; Silymarin/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Silibinin induced-autophagic and apoptotic death is associated with an increase in reactive oxygen and nitrogen species in HeLa cells.
Autorzy:
Fan S; China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China.
Li L
Chen S
Yu Y
Qi M
Tashiro S
Onodera S
Ikejima T
Pokaż więcej
Źródło:
Free radical research [Free Radic Res] 2011 Nov; Vol. 45 (11-12), pp. 1307-24. Date of Electronic Publication: 2011 Oct 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*drug effects
Autophagy/*drug effects
Reactive Nitrogen Species/*metabolism
Reactive Oxygen Species/*metabolism
Silymarin/*pharmacology
Acetylcysteine/metabolism ; Adenine/analogs & derivatives ; Adenine/pharmacology ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Beclin-1 ; Caspase 3/analysis ; Cell Survival ; Glutathione/metabolism ; HeLa Cells ; Humans ; Hydroxyl Radical/chemistry ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide Synthase/antagonists & inhibitors ; Silybin ; Silymarin/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells.
Autorzy:
Cheng Y; China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, China.
Qiu F
Ye YC
Guo ZM
Tashiro S
Onodera S
Ikejima T
Pokaż więcej
Źródło:
The FEBS journal [FEBS J] 2009 Mar; Vol. 276 (5), pp. 1291-306.
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy*
Diterpenes, Kaurane/*pharmacology
NF-kappa B/*metabolism
Reactive Oxygen Species/*metabolism
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Cell Line, Tumor ; Fibrosarcoma ; Mice ; Microscopy, Electron, Transmission ; NF-kappa B/antagonists & inhibitors ; Signal Transduction ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Silibinin-induced autophagy mediated by PPARα-sirt1-AMPK pathway participated in the regulation of type I collagen-enhanced migration in murine 3T3-L1 preadipocytes
Autorzy:
Liu, Xiaoling
Xu, Qian
Long, Xinyu
Liu, Weiwei
Zhao, Yeli
Hayashi, Toshihiko
Hattori, Shunji
Fujisaki, Hitomi
Ogura, Takaaki
Tashiro, Shin-ichi
Onodera, Satoshi
Yamato, Masayuki
Ikejima, Takashi
Pokaż więcej
Źródło:
Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease. 450(1-2):1-23
Czasopismo naukowe
Szczegóły
Tytuł:
Silibinin negatively contributes to primary cilia length via autophagy regulated by histone deacetylase 6 in confluent mouse embryo fibroblast 3T3-L1 cells
Autorzy:
Xu, Qian
Liu, Wei
Liu, Xiaoling
Liu, Weiwei
Wang, Hongju
Yao, Guodong
Zang, Linghe
Hayashi, Toshihiko
Tashiro, Shin-ichi
Onodera, Satoshi
Ikejima, Takashi
Pokaż więcej
Źródło:
Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease. September 2016 420(1-2):53-63
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 121

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