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Wyszukujesz frazę ""Tatler, Amanda L."" wg kryterium: Autor


Wyświetlanie 1-8 z 8
Tytuł :
Methods for the Assessment of Active Transforming Growth Factor-β in Cells and Tissues.
Autorzy :
John AE; Division of Respiratory Medicine, School of Medicine, Nottingham City Hospital, University of Nottingham, Nottingham, UK.
Porte J; Division of Respiratory Medicine, School of Medicine, Nottingham City Hospital, University of Nottingham, Nottingham, UK.
Jenkins G; Division of Respiratory Medicine, School of Medicine, Nottingham City Hospital, University of Nottingham, Nottingham, UK.
Tatler AL; Division of Respiratory Medicine, School of Medicine, Nottingham City Hospital, University of Nottingham, Nottingham, UK. Amanda.tatler@nottingham.ac.uk.
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2017; Vol. 1627, pp. 351-365.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Assay*/methods
Transforming Growth Factor beta/*metabolism
Animals ; Bronchoalveolar Lavage Fluid/cytology ; Cell Line, Transformed ; Cells, Cultured ; Culture Media, Conditioned/metabolism ; Immunohistochemistry ; Integrins/metabolism ; Lung/cytology ; Lung/metabolism ; Mink ; Phosphorylation ; Signal Transduction ; Smad2 Protein/metabolism ; Transforming Growth Factor beta/chemistry
Czasopismo naukowe
Tytuł :
Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33-mediated macrophage polarization and emphysema.
Autorzy :
John AE; Division of Respiratory Medicine, University of Nottingham, Nottingham, U.K. .
Wilson MR; Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College, London, U.K.
Habgood A; Division of Respiratory Medicine, University of Nottingham, Nottingham, U.K.
Porte J; Division of Respiratory Medicine, University of Nottingham, Nottingham, U.K.
Tatler AL; Division of Respiratory Medicine, University of Nottingham, Nottingham, U.K.
Stavrou A; Division of Respiratory Medicine, University of Nottingham, Nottingham, U.K.
Miele G; Epistem Ltd., Manchester, U.K.
Jolly L; Division of Respiratory Medicine, University of Nottingham, Nottingham, U.K.
Knox AJ; Division of Respiratory Medicine, University of Nottingham, Nottingham, U.K.
Takata M; Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College, London, U.K.
Offermanns S; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Jenkins RG; Division of Respiratory Medicine, University of Nottingham, Nottingham, U.K.
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Źródło :
Science signaling [Sci Signal] 2016 Oct 25; Vol. 9 (451), pp. ra104. Date of Electronic Publication: 2016 Oct 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Emphysema/*metabolism
GTP-Binding Protein alpha Subunits, Gq-G11/*metabolism
Interleukin-33/*metabolism
Macrophages, Alveolar/*metabolism
Respiratory Mucosa/*metabolism
Transforming Growth Factor beta/*metabolism
Animals ; Emphysema/genetics ; GTP-Binding Protein alpha Subunits, Gq-G11/genetics ; Interleukin-33/genetics ; Matrix Metalloproteinase 12/genetics ; Matrix Metalloproteinase 12/metabolism ; Mice ; Mice, Transgenic ; Respiratory Mucosa/pathology ; Transforming Growth Factor beta/genetics ; Ventilator-Induced Lung Injury/genetics ; Ventilator-Induced Lung Injury/metabolism
Czasopismo naukowe
Tytuł :
Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis.
Autorzy :
Tatler AL; Division of Respiratory Medicine-City, University of Nottingham, Nottingham, United Kingdom.
Goodwin AT; Division of Respiratory Medicine-City, University of Nottingham, Nottingham, United Kingdom.
Gbolahan O; Division of Respiratory Medicine-City, University of Nottingham, Nottingham, United Kingdom.
Saini G; Division of Respiratory Medicine-City, University of Nottingham, Nottingham, United Kingdom.
Porte J; Division of Respiratory Medicine-City, University of Nottingham, Nottingham, United Kingdom.
John AE; Division of Respiratory Medicine-City, University of Nottingham, Nottingham, United Kingdom.
Clifford RL; Division of Respiratory Medicine-City, University of Nottingham, Nottingham, United Kingdom.
Violette SM; Biogen, Cambridge, Massachusetts, United States of America.
Weinreb PH; Biogen, Cambridge, Massachusetts, United States of America.
Parfrey H; Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
Wolters PJ; School of Medicine, University of California San Francisco, San Francisco, California, United States of America.
Gauldie J; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.
Kolb M; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.
Jenkins G; Division of Respiratory Medicine-City, University of Nottingham, Nottingham, United Kingdom.
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Źródło :
PloS one [PLoS One] 2016 Aug 05; Vol. 11 (8), pp. e0158047. Date of Electronic Publication: 2016 Aug 05 (Print Publication: 2016).
Typ publikacji :
Journal Article
MeSH Terms :
Idiopathic Pulmonary Fibrosis/*pathology
Integrin beta Chains/*metabolism
Transcription, Genetic/*drug effects
Transforming Growth Factor beta/*pharmacology
Animals ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/metabolism ; Binding Sites ; Cells, Cultured ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Humans ; Idiopathic Pulmonary Fibrosis/metabolism ; Integrin beta Chains/genetics ; Integrins/genetics ; Integrins/metabolism ; Lung/drug effects ; Lung/metabolism ; Lung/pathology ; Mice ; Mice, Knockout ; Mutagenesis, Site-Directed ; Promoter Regions, Genetic ; RNA Stability/drug effects ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Smad3 Protein/genetics ; Smad3 Protein/metabolism ; Smad4 Protein/genetics ; Smad4 Protein/metabolism ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł :
Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices.
Autorzy :
Tatler AL; Division of Respiratory Medicine, Nottingham City Hospital, University of Nottingham, Nottingham, UK.
Barnes J; UCL Respiratory Centre for Inflammation and Tissue Repair, University College London, London, UK.
Habgood A; Division of Respiratory Medicine, Nottingham City Hospital, University of Nottingham, Nottingham, UK.
Goodwin A; Division of Respiratory Medicine, Nottingham City Hospital, University of Nottingham, Nottingham, UK.
McAnulty RJ; UCL Respiratory Centre for Inflammation and Tissue Repair, University College London, London, UK.
Jenkins G; Division of Respiratory Medicine, Nottingham City Hospital, University of Nottingham, Nottingham, UK.
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Źródło :
Thorax [Thorax] 2016 Jun; Vol. 71 (6), pp. 565-7. Date of Electronic Publication: 2016 Feb 24.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Caffeine/*pharmacology
Epithelial Cells/*drug effects
Fibroblasts/*drug effects
Pulmonary Fibrosis/*drug therapy
Pulmonary Fibrosis/*metabolism
Transforming Growth Factor beta/*metabolism
Animals ; Biomarkers/metabolism ; Cells, Cultured ; Epithelial Cells/metabolism ; Fibroblasts/metabolism ; Gene Expression Regulation/drug effects ; Humans ; Mice ; Pulmonary Fibrosis/genetics ; Signal Transduction/drug effects
Raport
Tytuł :
Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation.
Autorzy :
Jolly L; From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom.
Stavrou A; From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom.
Vanderstoken G; the McMaster Immunology Research Centre and Firestone Institute at St. Joseph's Health Care, McMaster University, Hamilton, Ontario L8S4L8, Canada, and.
Meliopoulos VA; the Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
Habgood A; From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom.
Tatler AL; From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom.
Porte J; From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom.
Knox A; From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom.
Weinreb P; Biogen Idec Inc., Cambridge, Massachusetts 02142.
Violette S; Biogen Idec Inc., Cambridge, Massachusetts 02142.
Hussell T; the Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester M13 9NT, United Kingdom.
Kolb M; the McMaster Immunology Research Centre and Firestone Institute at St. Joseph's Health Care, McMaster University, Hamilton, Ontario L8S4L8, Canada, and.
Stampfli MR; the McMaster Immunology Research Centre and Firestone Institute at St. Joseph's Health Care, McMaster University, Hamilton, Ontario L8S4L8, Canada, and.
Schultz-Cherry S; the Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
Jenkins G; From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom, .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2014 Dec 19; Vol. 289 (51), pp. 35246-63. Date of Electronic Publication: 2014 Oct 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Neoplasm/*metabolism
Collagen/*metabolism
Epithelial Cells/*metabolism
Integrins/*metabolism
Orthomyxoviridae Infections/*metabolism
Transforming Growth Factor beta/*metabolism
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives ; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology ; Animals ; Antigens, Neoplasm/genetics ; Antiviral Agents/pharmacology ; Apoptosis ; Cell Line, Transformed ; Dogs ; Epithelial Cells/drug effects ; Epithelial Cells/virology ; Host-Pathogen Interactions ; Humans ; Immunoblotting ; Influenza A Virus, H1N1 Subtype/physiology ; Integrins/genetics ; Lung/metabolism ; Lung/virology ; Madin Darby Canine Kidney Cells ; Mice, Inbred C57BL ; Mice, Knockout ; Orthomyxoviridae Infections/genetics ; Orthomyxoviridae Infections/virology ; Phosphorylation/drug effects ; Poly I-C/pharmacology ; Smad3 Protein/genetics ; Smad3 Protein/metabolism ; Toll-Like Receptor 3/metabolism ; Transforming Growth Factor beta/genetics ; rho-Associated Kinases/antagonists & inhibitors ; rho-Associated Kinases/metabolism
Czasopismo naukowe
Tytuł :
TGF-β activation and lung fibrosis.
Autorzy :
Tatler AL; Nottingham Respiratory Biomedical Research Unit, Nottingham University Hospitals, University of Nottingham, Hucknall Road, Nottingham, UK.
Jenkins G
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Źródło :
Proceedings of the American Thoracic Society [Proc Am Thorac Soc] 2012 Jul; Vol. 9 (3), pp. 130-6.
Typ publikacji :
Journal Article
MeSH Terms :
Airway Remodeling/*physiology
Integrin alpha Chains/*metabolism
Pulmonary Fibrosis/*metabolism
Transforming Growth Factor beta/*metabolism
Asthma/metabolism ; Epithelial Cells/metabolism ; Epithelial-Mesenchymal Transition ; Extracellular Matrix/metabolism ; Humans ; Integrin alphaV/metabolism ; Mesoderm/metabolism ; Pulmonary Alveoli/cytology ; Pulmonary Alveoli/metabolism
Czasopismo naukowe
Tytuł :
Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma.
Autorzy :
Tatler AL; Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham NG5 1PB, United Kingdom.
John AE
Jolly L
Habgood A
Porte J
Brightling C
Knox AJ
Pang L
Sheppard D
Huang X
Jenkins G
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2011 Dec 01; Vol. 187 (11), pp. 6094-107. Date of Electronic Publication: 2011 Oct 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Airway Remodeling/*immunology
Asthma/*metabolism
Myocytes, Smooth Muscle/*metabolism
Receptors, Vitronectin/*metabolism
Transforming Growth Factor beta/*metabolism
Animals ; Asthma/immunology ; Asthma/pathology ; Blotting, Western ; Cell Line ; Cell Separation ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Humans ; Immunohistochemistry ; Immunoprecipitation ; Mice ; Myocytes, Smooth Muscle/immunology ; Myocytes, Smooth Muscle/pathology ; Real-Time Polymerase Chain Reaction ; Receptors, Vitronectin/immunology ; Respiratory System ; Reverse Transcriptase Polymerase Chain Reaction ; Transfection ; Transforming Growth Factor beta/immunology
Czasopismo naukowe
Tytuł :
Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis.
Autorzy :
Tatler AL; Centre for Respiratory Research, Clinical Sciences Building, City Hospital, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK. />Porte J
Knox A
Jenkins G
Pang L
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2008 May 30; Vol. 370 (2), pp. 239-42. Date of Electronic Publication: 2008 Mar 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bronchi/*enzymology
Myocytes, Smooth Muscle/*enzymology
Transforming Growth Factor beta/*metabolism
Tryptases/*metabolism
Bronchi/cytology ; Guanidines/pharmacology ; Humans ; Leupeptins/pharmacology ; Oligopeptides/pharmacology ; Receptor, PAR-2/metabolism ; Trypsin Inhibitors/pharmacology ; Tryptases/antagonists & inhibitors
Czasopismo naukowe
    Wyświetlanie 1-8 z 8

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