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    Title:
    Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis.
    Authors:
    Tatler AL; Division of Respiratory Medicine-City, University of Nottingham, Nottingham, United Kingdom.
    Goodwin AT; Division of Respiratory Medicine-City, University of Nottingham, Nottingham, United Kingdom.
    Gbolahan O; Division of Respiratory Medicine-City, University of Nottingham, Nottingham, United Kingdom.
    Saini G; Division of Respiratory Medicine-City, University of Nottingham, Nottingham, United Kingdom.
    Porte J; Division of Respiratory Medicine-City, University of Nottingham, Nottingham, United Kingdom.
    John AE; Division of Respiratory Medicine-City, University of Nottingham, Nottingham, United Kingdom.
    Clifford RL; Division of Respiratory Medicine-City, University of Nottingham, Nottingham, United Kingdom.
    Violette SM; Biogen, Cambridge, Massachusetts, United States of America.
    Weinreb PH; Biogen, Cambridge, Massachusetts, United States of America.
    Parfrey H; Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
    Wolters PJ; School of Medicine, University of California San Francisco, San Francisco, California, United States of America.
    Gauldie J; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.
    Kolb M; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.
    Jenkins G; Division of Respiratory Medicine-City, University of Nottingham, Nottingham, United Kingdom.
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    Source:
    PloS one [PLoS One] 2016 Aug 05; Vol. 11 (8), pp. e0158047. Date of Electronic Publication: 2016 Aug 05 (Print Publication: 2016).
    Publication Type:
    Journal Article
    MeSH Terms:
    Idiopathic Pulmonary Fibrosis/*pathology
    Integrin beta Chains/*metabolism
    Transcription, Genetic/*drug effects
    Transforming Growth Factor beta/*pharmacology
    Animals ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/metabolism ; Binding Sites ; Cells, Cultured ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Humans ; Idiopathic Pulmonary Fibrosis/metabolism ; Integrin beta Chains/genetics ; Integrins/genetics ; Integrins/metabolism ; Lung/drug effects ; Lung/metabolism ; Lung/pathology ; Mice ; Mice, Knockout ; Mutagenesis, Site-Directed ; Promoter Regions, Genetic ; RNA Stability/drug effects ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Smad3 Protein/genetics ; Smad3 Protein/metabolism ; Smad4 Protein/genetics ; Smad4 Protein/metabolism ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism
    Academic Journal
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