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Wyświetlanie 1-41 z 41
Tytuł :
PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy
Autorzy :
Shakesheff, Kevin M.
Osman, Gizem
Rodriguez, Jason
Chan, Sze Yan
Chisholm, Jane
Duncan, Gregg
Kim, Namho
Tatler, Amanda L.
Hanes, Justin
Suk, Jung Soo
Dixon, James E.
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Temat :
Glycosaminoglycan-binding enhanced transduction (GET)
Lung
Cell-penetrating peptide (CPP)
Transfection
Gene therapy
transduction (GET)
Article
Plasmid DNA (pDNA)
Glycosaminoglycan-binding enhanced
Źródło :
Journal of controlled release : official journal of the Controlled Release Society
Opis pliku :
PDF; application/pdf
Tytuł :
A theoretical model of inflammation- and mechanotransduction-driven asthmatic airway remodelling
Autorzy :
Brook, Bindi S.
Hill, Michael
Philp, Christopher J.
Billington, Charlotte K.
Tatler, Amanda L.
Johnson, Simon R.
O'Dea, Reuben D.
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Temat :
respiratory system
respiratory tract diseases
Hyper-responsiveness
Multiphase
Morphoelastic
Airway smooth muscle
Mechanochemical
Original Paper
Bronchoconstriction
Źródło :
Biomechanics and Modeling in Mechanobiology
Opis pliku :
application/pdf
Tytuł :
Reduced Ets domain-containing protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression
Autorzy :
Tatler, Amanda L.
Habgood, Anthony
Porte, Joanne
John, Alison E.
Stavrou, Anastasios
Hodge, Emily
Kerama-Likoko, Cheryl
Violette, Shelia M.
Weinreb, Paul H.
Knox, Alan J.
Laurent, Geoffrey
Parfrey, Helen
Wolters, Paul John
Wallace, William
Alberti, Siegfried
Nordheim, Alfred
Jenkins, Gisli
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Temat :
lung
elk1
gene regulation
pulmonary fibrosis
fibrosis
Molecular Bases of Disease
integrin
Źródło :
The Journal of Biological Chemistry
Tatler, A L, Habgood, A, Porte, J, John, A E, Stavrou, A, Hodge, E, Kerama-Likoko, C, Violette, S M, Weinreb, P H, Knox, A J, Laurent, G, Parfrey, H, Wolters, P J, Wallace, W, Alberti, S, Nordheim, A & Jenkins, G 2016, ' Reduced Ets domain-containing protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression ', Journal of Biological Chemistry, vol. 291, no. 18, pp. 9540-9553 . https://doi.org/http://www.jbc.org/lookup/doi/10.1074/jbc.M115.692368
Opis pliku :
application/pdf
Tytuł :
Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis
Autorzy :
Jenkins, Gisli
Habgood, Antony
Tatler, Amanda L.
Porte, Joanne
Wahl, Sharon, M.
Laurent, Geoffrey, J.
John, Alison, E.
Johnson, Simon, R.
Pokaż więcej
Temat :
respiratory system
respiratory tract diseases
Article
Źródło :
Laboratory investigation; a journal of technical methods and pathology
Opis pliku :
application/pdf
Tytuł :
Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices.
Autorzy :
Tatler, Amanda L.
Barnes, Josephine
Habgood, Anthony
Goodwin, Amanda
McAnulty, Robin J.
Jenkins, Gisli
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Temat :
BLEOMYCIN
FIBROBLASTS
EPITHELIAL cells
ANTINEOPLASTIC antibiotics
PHYSIOLOGICAL effects of caffeine
TRANSFORMING growth factors-beta
ANIMAL experimentation
CAFFEINE
CELL culture
CELLULAR signal transduction
GENES
GROWTH factors
MICE
PULMONARY fibrosis
RESEARCH funding
PHARMACODYNAMICS
Źródło :
Thorax; Jun2016, Vol. 71 Issue 6, p565-567, 3p, 2 Graphs
Czasopismo naukowe
Tytuł :
Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression.
Autorzy :
Tatler, Amanda L. amanda.tatler@nottinham.ac.uk
Habgood, Anthony
Porte, Joanne
John, Alison E.
Stavrou, Anastasios
Hodge, Emily
Kerama-Likoko, Cheryl
Violette, Shelia M.
Weinreb, Paul H.
Laurent, Geoffrey
Parfrey, Helen
Wolters, Paul John
Wallace, William
Alberti, Siegfried
Nordheim, Alfred
Jenkins, Gisli
Pokaż więcej
Źródło :
Journal of Biological Chemistry. 4/29/2016, Vol. 291 Issue 18, p9540-9553. 14p.
Czasopismo naukowe
Tytuł :
Preclinical SPECT/CT Imaging of αvβ6 Integrins for Molecular Stratification of Idiopathic Pulmonary Fibrosis.
Autorzy :
John, Alison E.
Luckett, Jeni C.
Tatler, Amanda L.
Awais, Ramla O.
Desai, Ami
Habgood, Anthony
Ludbrook, Steve
Blanchard, Andy D.
Perkins, Alan C.
Jenkins, R. Gisli
Marshall, John F.
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Źródło :
Journal of Nuclear Medicine; Dec2013, Vol. 54 Issue 12, p2146-2152, 7p, 3 Color Photographs, 3 Black and White Photographs
Czasopismo naukowe
Tytuł :
Influenza Promotes Collagen Deposition via αvβ6 Integrin-mediated Transforming Growth Factor β Activation.
Autorzy :
Jolly, Lisa
Stavrou, Anastasios
Vanderstoken, Gilles
Meliopoulos, Victoria A.
Habgood, Anthony
Tatler, Amanda L.
Porte, Joanne
Knox, Alan
Weinreb, Paul
Violette, Shelia
Hussell, Tracy
Kolb, Martin
Stampfli, Martin R.
Schultz-Cherry, Stacey
Jenkins, Gisli
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Źródło :
Journal of Biological Chemistry. 12/19/2014, Vol. 289 Issue 51, p35246-35263. 18p.
Czasopismo naukowe
Tytuł :
Methods for the Assessment of Active Transforming Growth Factor-β in Cells and Tissues.
Autorzy :
John AE; Division of Respiratory Medicine, School of Medicine, Nottingham City Hospital, University of Nottingham, Nottingham, UK.
Porte J; Division of Respiratory Medicine, School of Medicine, Nottingham City Hospital, University of Nottingham, Nottingham, UK.
Jenkins G; Division of Respiratory Medicine, School of Medicine, Nottingham City Hospital, University of Nottingham, Nottingham, UK.
Tatler AL; Division of Respiratory Medicine, School of Medicine, Nottingham City Hospital, University of Nottingham, Nottingham, UK. Amanda.tatler@nottingham.ac.uk.
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2017; Vol. 1627, pp. 351-365.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Assay*/methods
Transforming Growth Factor beta/*metabolism
Animals ; Bronchoalveolar Lavage Fluid/cytology ; Cell Line, Transformed ; Cells, Cultured ; Culture Media, Conditioned/metabolism ; Immunohistochemistry ; Integrins/metabolism ; Lung/cytology ; Lung/metabolism ; Mink ; Phosphorylation ; Signal Transduction ; Smad2 Protein/metabolism ; Transforming Growth Factor beta/chemistry
Czasopismo naukowe
Tytuł :
Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33-mediated macrophage polarization and emphysema.
Autorzy :
John AE; Division of Respiratory Medicine, University of Nottingham, Nottingham, U.K. .
Wilson MR; Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College, London, U.K.
Habgood A; Division of Respiratory Medicine, University of Nottingham, Nottingham, U.K.
Porte J; Division of Respiratory Medicine, University of Nottingham, Nottingham, U.K.
Tatler AL; Division of Respiratory Medicine, University of Nottingham, Nottingham, U.K.
Stavrou A; Division of Respiratory Medicine, University of Nottingham, Nottingham, U.K.
Miele G; Epistem Ltd., Manchester, U.K.
Jolly L; Division of Respiratory Medicine, University of Nottingham, Nottingham, U.K.
Knox AJ; Division of Respiratory Medicine, University of Nottingham, Nottingham, U.K.
Takata M; Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College, London, U.K.
Offermanns S; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Jenkins RG; Division of Respiratory Medicine, University of Nottingham, Nottingham, U.K.
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Źródło :
Science signaling [Sci Signal] 2016 Oct 25; Vol. 9 (451), pp. ra104. Date of Electronic Publication: 2016 Oct 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Emphysema/*metabolism
GTP-Binding Protein alpha Subunits, Gq-G11/*metabolism
Interleukin-33/*metabolism
Macrophages, Alveolar/*metabolism
Respiratory Mucosa/*metabolism
Transforming Growth Factor beta/*metabolism
Animals ; Emphysema/genetics ; GTP-Binding Protein alpha Subunits, Gq-G11/genetics ; Interleukin-33/genetics ; Matrix Metalloproteinase 12/genetics ; Matrix Metalloproteinase 12/metabolism ; Mice ; Mice, Transgenic ; Respiratory Mucosa/pathology ; Transforming Growth Factor beta/genetics ; Ventilator-Induced Lung Injury/genetics ; Ventilator-Induced Lung Injury/metabolism
Czasopismo naukowe
Tytuł :
Reducing affinity of αvβ8 interactions with latent TGFβ: dialling down fibrosis.
Autorzy :
Tatler AL; Division of Respiratory Medicine, City Hospital Campus, University of Nottingham, Nottingham, UK.
Jenkins G; Division of Respiratory Medicine, City Hospital Campus, University of Nottingham, Nottingham, UK.
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Źródło :
Annals of translational medicine [Ann Transl Med] 2015 May; Vol. 3 (Suppl 1), pp. S31.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET.
Autorzy :
Clifford RL; Department of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Nottingham, United Kingdom; and.
Patel JK; Department of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Nottingham, United Kingdom; and.
John AE; Department of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Nottingham, United Kingdom; and.
Tatler AL; Department of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Nottingham, United Kingdom; and.
Mazengarb L; Department of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Nottingham, United Kingdom; and.
Brightling CE; Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.
Knox AJ; Department of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Nottingham, United Kingdom; and .
Pokaż więcej
Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2015 May 01; Vol. 308 (9), pp. L962-72. Date of Electronic Publication: 2015 Feb 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Asthma/*metabolism
Interleukin-8/*metabolism
Muscle, Smooth/*metabolism
Myocytes, Smooth Muscle/*metabolism
Nerve Tissue Proteins/*metabolism
Acetylation ; Airway Remodeling/immunology ; CCAAT-Enhancer-Binding Protein-beta/metabolism ; Cell Cycle Proteins ; Cells, Cultured ; DNA Methylation ; DNA-Binding Proteins/metabolism ; Histones/metabolism ; Humans ; Inflammation/immunology ; Interleukin-8/antagonists & inhibitors ; Interleukin-8/genetics ; Nerve Tissue Proteins/antagonists & inhibitors ; Nuclear Proteins/antagonists & inhibitors ; Nuclear Proteins/metabolism ; Primary Cell Culture ; Promoter Regions, Genetic ; Protein Binding ; RNA Polymerase II/metabolism ; RNA-Binding Proteins/antagonists & inhibitors ; RNA-Binding Proteins/metabolism ; Transcription Factor RelA/metabolism ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/metabolism ; Transcription, Genetic ; p300-CBP Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
TGF-β activation and lung fibrosis.
Autorzy :
Tatler AL; Nottingham Respiratory Biomedical Research Unit, Nottingham University Hospitals, University of Nottingham, Hucknall Road, Nottingham, UK.
Jenkins G
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Źródło :
Proceedings of the American Thoracic Society [Proc Am Thorac Soc] 2012 Jul; Vol. 9 (3), pp. 130-6.
Typ publikacji :
Journal Article
MeSH Terms :
Airway Remodeling/*physiology
Integrin alpha Chains/*metabolism
Pulmonary Fibrosis/*metabolism
Transforming Growth Factor beta/*metabolism
Asthma/metabolism ; Epithelial Cells/metabolism ; Epithelial-Mesenchymal Transition ; Extracellular Matrix/metabolism ; Humans ; Integrin alphaV/metabolism ; Mesoderm/metabolism ; Pulmonary Alveoli/cytology ; Pulmonary Alveoli/metabolism
Czasopismo naukowe
Tytuł :
Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis.
Autorzy :
Tatler AL; Centre for Respiratory Research, Clinical Sciences Building, City Hospital, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK. />Porte J
Knox A
Jenkins G
Pang L
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2008 May 30; Vol. 370 (2), pp. 239-42. Date of Electronic Publication: 2008 Mar 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bronchi/*enzymology
Myocytes, Smooth Muscle/*enzymology
Transforming Growth Factor beta/*metabolism
Tryptases/*metabolism
Bronchi/cytology ; Guanidines/pharmacology ; Humans ; Leupeptins/pharmacology ; Oligopeptides/pharmacology ; Receptor, PAR-2/metabolism ; Trypsin Inhibitors/pharmacology ; Tryptases/antagonists & inhibitors
Czasopismo naukowe
    Wyświetlanie 1-41 z 41

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