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Wyszukujesz frazę ""Tau"" wg kryterium: Temat


Tytuł:
Phosphorylation regulates tau's phase separation behavior and interactions with chromatin.
Autorzy:
Abasi LS; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093, USA.
Elathram N; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093, USA.
Movva M; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093, USA.
Deep A; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Corbett KD; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.; Department of Molecular Biology, University of California San Diego, La Jolla, CA, 92093, USA.
Debelouchina GT; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093, USA. .
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Źródło:
Communications biology [Commun Biol] 2024 Mar 01; Vol. 7 (1), pp. 251. Date of Electronic Publication: 2024 Mar 01.
Typ publikacji:
Journal Article
MeSH Terms:
Chromatin*/chemistry
Chromatin*/metabolism
tau Proteins*/chemistry
tau Proteins*/metabolism
Humans ; DNA/metabolism ; Heterochromatin ; Nucleosomes ; Phase Separation ; Phosphorylation
Czasopismo naukowe
Tytuł:
Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells.
Autorzy:
Padmanabhan P; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, 4072, Brisbane, Australia. .
Kneynsberg A; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, 4072, Brisbane, Australia.
Cruz E; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, 4072, Brisbane, Australia.
Briner A; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, 4072, Brisbane, Australia.
Götz J; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, 4072, Brisbane, Australia. .
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Źródło:
Molecular brain [Mol Brain] 2024 Feb 12; Vol. 17 (1), pp. 7. Date of Electronic Publication: 2024 Feb 12.
Typ publikacji:
Journal Article
MeSH Terms:
tau Proteins*/metabolism
Alzheimer Disease*/pathology
Humans ; Phosphorylation ; Single Molecule Imaging ; Microtubules/metabolism
Czasopismo naukowe
Tytuł:
A Novel Cre Recombinase Mouse Strain for Cell-Specific Deletion of Floxed Genes in Ribbon Synapse-Forming Retinal Neurons.
Autorzy:
Suiwal S; Institute of Anatomy and Cell Biology, Department of Neuroanatomy, Medical School, Saarland University, 66421 Homburg, Germany.
Wartenberg P; Institute of Clinical and Experimental Pharmacology, Center for Molecular Signaling (PZMS) and Center for Gender-Specific Biology and Medicine (CGBM), Medical School, Saarland University, 66421 Homburg, Germany.
Boehm U; Institute of Clinical and Experimental Pharmacology, Center for Molecular Signaling (PZMS) and Center for Gender-Specific Biology and Medicine (CGBM), Medical School, Saarland University, 66421 Homburg, Germany.
Schmitz F; Institute of Anatomy and Cell Biology, Department of Neuroanatomy, Medical School, Saarland University, 66421 Homburg, Germany.
Schwarz K; Institute of Anatomy and Cell Biology, Department of Neuroanatomy, Medical School, Saarland University, 66421 Homburg, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 05; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
tau Proteins*/metabolism
Retinal Neurons*/metabolism
Mice ; Animals ; Mice, Transgenic ; Synapses/metabolism ; Integrases/genetics ; Integrases/metabolism ; Green Fluorescent Proteins/metabolism
Czasopismo naukowe
Tytuł:
2-Aminothiazole-Flavonoid Hybrid Derivatives Binding to Tau Protein and Responsible for Antitumor Activity in Glioblastoma.
Autorzy:
Hedna R; Faculté des Sciences Médicales et Paramédicales, Institut de Neurophysiopathologie (INP), UMR 7051, CNRS, Aix Marseille Université, 13005 Marseille, France.
DiMaio A; Faculté de Pharmacie, Institut Méditerranéen de Biodiversité et Ecologie Marine et Continentale (IMBE), UMR 7263, CNRS, IRD 237, Aix-Marseille Université, 13005 Marseille, France.
Robin M; Faculté de Pharmacie, Institut Méditerranéen de Biodiversité et Ecologie Marine et Continentale (IMBE), UMR 7263, CNRS, IRD 237, Aix-Marseille Université, 13005 Marseille, France.
Allegro D; Faculté des Sciences Médicales et Paramédicales, Institut de Neurophysiopathologie (INP), UMR 7051, CNRS, Aix Marseille Université, 13005 Marseille, France.
Tatoni M; Faculté des Sciences Médicales et Paramédicales, Institut de Neurophysiopathologie (INP), UMR 7051, CNRS, Aix Marseille Université, 13005 Marseille, France.
Peyrot V; Faculté des Sciences Médicales et Paramédicales, Institut de Neurophysiopathologie (INP), UMR 7051, CNRS, Aix Marseille Université, 13005 Marseille, France.
Barbier P; Faculté des Sciences Médicales et Paramédicales, Institut de Neurophysiopathologie (INP), UMR 7051, CNRS, Aix Marseille Université, 13005 Marseille, France.
Kovacic H; Faculté des Sciences Médicales et Paramédicales, Institut de Neurophysiopathologie (INP), UMR 7051, CNRS, Aix Marseille Université, 13005 Marseille, France.
Breuzard G; Faculté des Sciences Médicales et Paramédicales, Institut de Neurophysiopathologie (INP), UMR 7051, CNRS, Aix Marseille Université, 13005 Marseille, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 10; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 10.
Typ publikacji:
Journal Article
MeSH Terms:
tau Proteins*/metabolism
Glioblastoma*/metabolism
Humans ; Microtubules/metabolism ; Thiazoles/pharmacology ; Tubulin/metabolism ; Protein Binding
Czasopismo naukowe
Tytuł:
Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau.
Autorzy:
Schweighauser M; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Murzin AG; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Macdonald J; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Lavenir I; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Crowther RA; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Scheres SHW; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK. .
Goedert M; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Oct 05; Vol. 11 (1), pp. 160. Date of Electronic Publication: 2023 Oct 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
tau Proteins*/metabolism
Tauopathies*/metabolism
Humans ; Mice ; Animals ; Cryoelectron Microscopy ; Mice, Transgenic ; Brain/metabolism ; Cytoskeleton/metabolism ; Disease Models, Animal
Czasopismo naukowe
Tytuł:
Low-dose brain radiation: lowering hyperphosphorylated-tau without increasing DNA damage or oncogenic activation.
Autorzy:
Iacono D; DoD/USU Brain Tissue Repository and Neuropathology Program, Uniformed Services University (USU), Bethesda, MD, USA. .; Department of Neurology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA. .; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA. .; Neuroscience Program, Department of Anatomy, Physiology and Genetics, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA. .; The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) Inc., Bethesda, MD, USA. .; Neurodegeneration Disorders Clinic, National Institute of Neurological Disorders and Stroke, NINDS, NIH, Bethesda, MD, USA. .
Murphy EK; DoD/USU Brain Tissue Repository and Neuropathology Program, Uniformed Services University (USU), Bethesda, MD, USA.; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) Inc., Bethesda, MD, USA.
Stimpson CD; DoD/USU Brain Tissue Repository and Neuropathology Program, Uniformed Services University (USU), Bethesda, MD, USA.; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) Inc., Bethesda, MD, USA.
Perl DP; DoD/USU Brain Tissue Repository and Neuropathology Program, Uniformed Services University (USU), Bethesda, MD, USA.; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA.
Day RM; Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA.
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 30; Vol. 13 (1), pp. 21142. Date of Electronic Publication: 2023 Nov 30.
Typ publikacji:
Journal Article
MeSH Terms:
tau Proteins*/metabolism
Alzheimer Disease*/metabolism
Animals ; Swine ; Brain/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; DNA Damage ; Amyloid beta-Peptides/metabolism ; Phosphorylation ; Mammals/metabolism
Czasopismo naukowe
Tytuł:
Effect of Low Concentration of Nitroxides on SH-SY5Y Cells Transfected with the Tau Protein.
Autorzy:
Bartosz G; Laboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, Rzeszow University, 4 Zelwerowicza Street, 35-601 Rzeszow, Poland.
Pieńkowska N; Laboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, Rzeszow University, 4 Zelwerowicza Street, 35-601 Rzeszow, Poland.
Kut K; Laboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, Rzeszow University, 4 Zelwerowicza Street, 35-601 Rzeszow, Poland.
Cieniek B; Institute of Materials Engineering, College of Natural Sciences, University of Rzeszów, 35-310 Rzeszów, Poland.
Stefaniuk I; Institute of Materials Engineering, College of Natural Sciences, University of Rzeszów, 35-310 Rzeszów, Poland.
Sadowska-Bartosz I; Laboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, Rzeszow University, 4 Zelwerowicza Street, 35-601 Rzeszow, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 23; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 23.
Typ publikacji:
Journal Article
MeSH Terms:
tau Proteins*/genetics
Neuroblastoma*
Animals ; Humans ; Nitrogen Oxides/pharmacology ; Antioxidants/pharmacology ; Cyclic N-Oxides/pharmacology
Czasopismo naukowe
Tytuł:
Tau accumulation in degradative organelles is associated to lysosomal stress.
Autorzy:
Piovesana E; Laboratory for Aging Disorders, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; PhD Program in Neurosciences, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
Magrin C; Laboratory for Aging Disorders, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; PhD Program in Neurosciences, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
Ciccaldo M; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland.
Sola M; Laboratory for Aging Disorders, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; PhD Program in Neurosciences, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
Bellotto M; GT Gain Therapeutics SA, Lugano, Switzerland.
Molinari M; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland.; School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Papin S; Laboratory for Aging Disorders, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Paganetti P; Laboratory for Aging Disorders, Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland. .; PhD Program in Neurosciences, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland. .; Neurocentro della Svizzera Italiana, Ente Ospedaliero Cantonale, Lugano, Switzerland. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 21; Vol. 13 (1), pp. 18024. Date of Electronic Publication: 2023 Oct 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neurodegenerative Diseases*/metabolism
tau Proteins*/metabolism
Humans ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism ; Alzheimer Disease/metabolism ; Amyloidogenic Proteins/metabolism ; Lysosomes/metabolism ; Parkinson Disease/metabolism
Czasopismo naukowe
Tytuł:
Distinct Molecular Signatures of Amyloid-Beta and Tau in Alzheimer's Disease Associated with Down Syndrome.
Autorzy:
Ichimata S; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON M5T 2S8, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.; Department of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama 930-8555, Japan.
Martinez-Valbuena I; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON M5T 2S8, Canada.
Lee S; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON M5T 2S8, Canada.
Li J; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON M5T 2S8, Canada.
Karakani AM; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON M5T 2S8, Canada.
Kovacs GG; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON M5T 2S8, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada.; Edmond J. Safra Program in Parkinson's Disease, Rossy Program for PSP Research and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON M5T 2S8, Canada.; Laboratory Medicine Program, Krembil Brain Institute, University Health Network, Toronto, ON M5G 2C4, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 18; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 18.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Alzheimer Disease*/pathology
Amyloid beta-Peptides*/genetics
Amyloid beta-Peptides*/metabolism
Down Syndrome*/genetics
Down Syndrome*/metabolism
Down Syndrome*/pathology
tau Proteins*/genetics
tau Proteins*/metabolism
Humans ; Cerebellum/metabolism ; Peptide Fragments ; Temporal Lobe/metabolism
Czasopismo naukowe
Tytuł:
Neurodegeneration or dysfunction in Phelan-McDermid syndrome? A multimodal approach with CSF and computational MRI.
Autorzy:
Jesse S; Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, D-89081, Ulm, Germany. .; German Centre of Neurodegenerative Diseases (DZNE), Ulm, Germany. .
Müller HP; Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, D-89081, Ulm, Germany.
Huppertz HJ; Swiss Epilepsy Clinic, Hospital Lengg, Zürich, Switzerland.
Andres S; Medicover München Ost MVZ, Humangenetik, Munich, Germany.
Ludolph AC; Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, D-89081, Ulm, Germany.; German Centre of Neurodegenerative Diseases (DZNE), Ulm, Germany.
Schön M; Institute of Anatomy and Cell Biology, Ulm University, Ulm, Germany.
Boeckers TM; German Centre of Neurodegenerative Diseases (DZNE), Ulm, Germany.; Institute of Anatomy and Cell Biology, Ulm University, Ulm, Germany.
Kassubek J; Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, D-89081, Ulm, Germany.; German Centre of Neurodegenerative Diseases (DZNE), Ulm, Germany.
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Źródło:
Orphanet journal of rare diseases [Orphanet J Rare Dis] 2023 Sep 05; Vol. 18 (1), pp. 274. Date of Electronic Publication: 2023 Sep 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
tau Proteins*
Alzheimer Disease*
Humans ; Diffusion Tensor Imaging ; Magnetic Resonance Imaging
SCR Disease Name:
Telomeric 22q13 Monosomy Syndrome
Czasopismo naukowe
Tytuł:
Small molecule inhibitor of tau self-association in a mouse model of tauopathy: A preventive study in P301L tau JNPL3 mice.
Autorzy:
Davidowitz EJ; Oligomerix, Inc., White Plains, NY, United States of America.; Oligomerix, Inc., Bronx, NY, United States of America.
Lopez P; Oligomerix, Inc., Bronx, NY, United States of America.
Jimenez H; The Litwin-Zucker Research Center for the Study of Alzheimer's Disease, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States of America.
Adrien L; The Litwin-Zucker Research Center for the Study of Alzheimer's Disease, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States of America.
Davies P; The Litwin-Zucker Research Center for the Study of Alzheimer's Disease, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States of America.
Moe JG; Oligomerix, Inc., White Plains, NY, United States of America.; Oligomerix, Inc., Bronx, NY, United States of America.
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Źródło:
PloS one [PLoS One] 2023 Aug 09; Vol. 18 (8), pp. e0286523. Date of Electronic Publication: 2023 Aug 09 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Neurodegenerative Diseases*
tau Proteins*/antagonists & inhibitors
tau Proteins*/metabolism
Tauopathies*/drug therapy
Tauopathies*/prevention & control
Tauopathies*/genetics
Animals ; Humans ; Mice ; Disease Models, Animal ; Mice, Transgenic ; Rhombencephalon/metabolism
Czasopismo naukowe
Tytuł:
Lamivudine (3TC), a Nucleoside Reverse Transcriptase Inhibitor, Prevents the Neuropathological Alterations Present in Mutant Tau Transgenic Mice.
Autorzy:
Vallés-Saiz L; Centro de Biología Molecular 'Severo Ochoa', CSIC/UAM, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
Ávila J; Centro de Biología Molecular 'Severo Ochoa', CSIC/UAM, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
Hernández F; Centro de Biología Molecular 'Severo Ochoa', CSIC/UAM, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 06; Vol. 24 (13). Date of Electronic Publication: 2023 Jul 06.
Typ publikacji:
Journal Article
MeSH Terms:
tau Proteins*/genetics
Tauopathies*/drug therapy
Tauopathies*/genetics
Tauopathies*/pathology
Mice ; Humans ; Animals ; Mice, Transgenic ; Reverse Transcriptase Inhibitors/pharmacology ; Lamivudine/pharmacology ; HeLa Cells ; Disease Models, Animal
Czasopismo naukowe
Tytuł:
Tau protein aggregation associated with SARS-CoV-2 main protease.
Autorzy:
Eberle RJ; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, Jülich, Germany.; Institute of Physical Biology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Coronado MA; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, Jülich, Germany.
Gering I; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, Jülich, Germany.
Sommerhage S; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, Jülich, Germany.
Korostov K; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, Jülich, Germany.
Stefanski A; Molecular Proteomics Laboratory (MPL), BMFZ, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Stühler K; Molecular Proteomics Laboratory (MPL), BMFZ, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Kraemer-Schulien V; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, Jülich, Germany.
Blömeke L; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, Jülich, Germany.; Institute of Physical Biology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Bannach O; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, Jülich, Germany.; Institute of Physical Biology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.; attyloid GmbH, Düsseldorf, Germany.
Willbold D; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, Jülich, Germany.; Institute of Physical Biology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.; JuStruct: Jülich Centre for Structural Biology, Forschungszentrum Jülich, Jülich, Germany.
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Źródło:
PloS one [PLoS One] 2023 Aug 21; Vol. 18 (8), pp. e0288138. Date of Electronic Publication: 2023 Aug 21 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Coronavirus 3C Proteases*/metabolism
COVID-19*
Protein Aggregates*
tau Proteins*/metabolism
Humans ; Endopeptidases ; Peptide Hydrolases ; SARS-CoV-2
Czasopismo naukowe
Tytuł:
Trimming away tau in neurodegeneration.
Autorzy:
Noble W; University of Exeter, Exeter, UK.
Hanger DP; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Jul 28; Vol. 381 (6656), pp. 377-378. Date of Electronic Publication: 2023 Jul 27.
Typ publikacji:
Journal Article
MeSH Terms:
tau Proteins*
Tripartite Motif Proteins*
Ubiquitin-Protein Ligases*
Animals ; Mice
Czasopismo naukowe
Tytuł:
Genetically Engineered Triple MAPT -Mutant Human-Induced Pluripotent Stem Cells (N279K, P301L, and E10+16 Mutations) Exhibit Impairments in Mitochondrial Bioenergetics and Dynamics.
Autorzy:
Szabo L; Research Cluster Molecular and Cognitive Neurosciences, University of Basel, 4002 Basel, Switzerland.; Neurobiology Lab for Brain Aging and Mental Health, University Psychiatric Clinics Basel, 4002 Basel, Switzerland.
Grimm A; Research Cluster Molecular and Cognitive Neurosciences, University of Basel, 4002 Basel, Switzerland.; Neurobiology Lab for Brain Aging and Mental Health, University Psychiatric Clinics Basel, 4002 Basel, Switzerland.; Department of Biomedicine, University of Basel, 4055 Basel, Switzerland.
García-León JA; Departamento Biologia Celular, Genetica y Fisiologia, Instituto de Investigacion Biomedica de Malaga-IBIMA, Facultad de Ciencias, Universidad de Malaga, 29071 Malaga, Spain.; Centro de Investigacion Biomedica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain.
Verfaillie CM; Department of Development and Regeneration, Stem Cell Institute, KU Leuven, 3000 Leuven, Belgium.
Eckert A; Research Cluster Molecular and Cognitive Neurosciences, University of Basel, 4002 Basel, Switzerland.; Neurobiology Lab for Brain Aging and Mental Health, University Psychiatric Clinics Basel, 4002 Basel, Switzerland.
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Źródło:
Cells [Cells] 2023 May 13; Vol. 12 (10). Date of Electronic Publication: 2023 May 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
tau Proteins*/genetics
tau Proteins*/metabolism
Induced Pluripotent Stem Cells*/metabolism
Humans ; Mutation/genetics ; Mitochondria/metabolism ; Energy Metabolism
Czasopismo naukowe
Tytuł:
The relationship between obstructive sleep apnea and circulating tau levels: A meta-analysis.
Autorzy:
Huang ZW; Department of Otolaryngology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian Province, People's Republic of China.
Zeng HX; Department of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, People's Republic of China.
Huang YP; Department of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, People's Republic of China.
Wang TZ; Department of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, People's Republic of China.
Huang WS; Department of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, People's Republic of China.
Huang YF; Department of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, People's Republic of China.
Lin L; Department of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, People's Republic of China.
Li H; Department of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, People's Republic of China.
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Źródło:
Brain and behavior [Brain Behav] 2023 Apr; Vol. 13 (4), pp. e2972. Date of Electronic Publication: 2023 Mar 20.
Typ publikacji:
Meta-Analysis; Journal Article
MeSH Terms:
Sleep Apnea, Obstructive*/blood
tau Proteins*/blood
tau Proteins*/metabolism
Humans ; Phosphorylation
Czasopismo naukowe
Tytuł:
Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer's Disease.
Autorzy:
Lantero-Rodriguez J; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg, House V3/SU, 43180, Mölndal, Sweden. .
Salvadó G; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Snellman A; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg, House V3/SU, 43180, Mölndal, Sweden.; Turku PET Centre, University of Turku, Turku University Hospital, Turku, Finland.
Montoliu-Gaya L; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg, House V3/SU, 43180, Mölndal, Sweden.
Brum WS; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg, House V3/SU, 43180, Mölndal, Sweden.; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, Brazil.
Benedet AL; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg, House V3/SU, 43180, Mölndal, Sweden.
Mattsson-Carlgren N; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.; Department of Neurology, Skåne University Hospital, Lund, Sweden.; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.
Tideman P; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, 20502, Malmö, Sweden.
Janelidze S; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Palmqvist S; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Stomrud E; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, 20502, Malmö, Sweden.
Ashton NJ; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg, House V3/SU, 43180, Mölndal, Sweden.; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.; Department of Old Age Psychiatry, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK.; NIHR Biomedical Research Centre for Mental Health & Biomedical Research Unit for Dementia at South London & Maudsley NHS Foundation, London, UK.
Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg, House V3/SU, 43180, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London, UK.; UK Dementia Research Institute, University College London, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg, House V3/SU, 43180, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden. .; Memory Clinic, Skåne University Hospital, 20502, Malmö, Sweden. .
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Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2024 Feb 17; Vol. 19 (1), pp. 19. Date of Electronic Publication: 2024 Feb 17.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*
Cognitive Dysfunction*
Humans ; tau Proteins ; Amyloid beta-Peptides ; Atrophy ; Biomarkers ; Disease Progression ; Positron-Emission Tomography
Czasopismo naukowe
Tytuł:
A single-domain antibody for the detection of pathological Tau protein in the early stages of oligomerization.
Autorzy:
De Leiris N; University Grenoble Alpes, Clinique Universitaire de Médecine Nucléaire, INSERM, Centre Hospitalier Universitaire Grenoble Alpes, LRB, CS 10217, 38043, Grenoble CEDEX 9, France. .
Perret P; University Grenoble Alpes, INSERM, LRB, 38000, Grenoble, France.
Lombardi C; University Grenoble Alpes, INSERM, LRB, 38000, Grenoble, France.
Gözel B; University Grenoble Alpes, INSERM, LRB, 38000, Grenoble, France.
Chierici S; University Grenoble Alpes, CNRS, DCM, 38000, Grenoble, France.
Millet P; Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland.
Debiossat M; University Grenoble Alpes, INSERM, LRB, 38000, Grenoble, France.
Bacot S; University Grenoble Alpes, INSERM, LRB, 38000, Grenoble, France.
Tournier BB; Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland.
Chames P; Aix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Marseille, France.
Lenormand JL; University Grenoble Alpes, CNRS, TIMC, 38000, Grenoble, France.
Ghezzi C; University Grenoble Alpes, INSERM, LRB, 38000, Grenoble, France.
Fagret D; University Grenoble Alpes, INSERM, LRB, 38000, Grenoble, France.
Moulin M; University Grenoble Alpes, INSERM, LRB, 38000, Grenoble, France.
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Źródło:
Journal of translational medicine [J Transl Med] 2024 Feb 16; Vol. 22 (1), pp. 163. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Single-Domain Antibodies*/chemistry
Single-Domain Antibodies*/metabolism
Animals ; Humans ; Mice ; Brain/pathology ; tau Proteins/chemistry ; tau Proteins/immunology ; Tissue Distribution
Czasopismo naukowe
Tytuł:
Effects of certain pre-analytical factors on the performance of plasma phospho-tau217.
Autorzy:
Bali D; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Sölvegatan 19, BMC B11, 22184, Lund, Sweden. .
Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Sölvegatan 19, BMC B11, 22184, Lund, Sweden.; Memory Clinic, Skåne University Hospital, 20502, Malmö, Sweden.
Janelidze S; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Sölvegatan 19, BMC B11, 22184, Lund, Sweden. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Feb 08; Vol. 16 (1), pp. 31. Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Ice*
Alzheimer Disease*/cerebrospinal fluid
Humans ; Peptide Fragments/cerebrospinal fluid ; Amyloid beta-Peptides/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; tau Proteins/cerebrospinal fluid
Czasopismo naukowe
Tytuł:
Associations between cardiometabolic multimorbidity and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: the CABLE study.
Autorzy:
Li QY; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 Donghai Middle Road, Qingdao, China.
Hu HY; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 Donghai Middle Road, Qingdao, China.
Zhang GW; Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Hu H; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 Donghai Middle Road, Qingdao, China.
Ou YN; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 Donghai Middle Road, Qingdao, China.
Huang LY; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 Donghai Middle Road, Qingdao, China.
Wang AY; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 Donghai Middle Road, Qingdao, China.
Gao PY; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 Donghai Middle Road, Qingdao, China.
Ma LY; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 Donghai Middle Road, Qingdao, China.
Tan L; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 Donghai Middle Road, Qingdao, China. .
Yu JT; Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, No. 12 Wulumuqi Road, Shanghai, China. jintai_.
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Feb 06; Vol. 16 (1), pp. 28. Date of Electronic Publication: 2024 Feb 06.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/cerebrospinal fluid
Hypertension*
Diabetes Mellitus*
Adult ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Apolipoprotein E4/cerebrospinal fluid ; Multimorbidity ; tau Proteins/cerebrospinal fluid ; Amyloid beta-Peptides/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; Peptide Fragments/cerebrospinal fluid
Czasopismo naukowe

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