Tuberous Sclerosis Complex cell-derived EVs have an altered protein cargo capable of regulating their microenvironment and have potential as disease biomarkers.
Autorzy:
Bhaoighill MN; Tissue Microenvironment Group, School of Medicine, Cardiff University, Cardiff, UK.; Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK. Falcón-Pérez JM; Exosomes Lab. CICbioGUNE-BRTA, Parque Tecnologico, Derio, Spain.; Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Madrid, Spain.; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain. Royo F; Exosomes Lab. CICbioGUNE-BRTA, Parque Tecnologico, Derio, Spain.; Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Madrid, Spain. TeeAR; Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK. Webber JP; Tissue Microenvironment Group, School of Medicine, Cardiff University, Cardiff, UK.; Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, UK. Dunlop EA; Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK.
Drug Inhibition of Redox Factor-1 Restores Hypoxia-Driven Changes in Tuberous Sclerosis Complex 2 Deficient Cells.
Autorzy:
Champion JD; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Dodd KM; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Lam HC; Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Alzahrani MAM; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Seifan S; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Rad E; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Scourfield DO; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Fishel ML; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Calver BL; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Ager A; Division of Infection and Immunity, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Henske EP; Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Davies DM; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.; Department of Oncology, South West Wales Cancer Centre, Singleton Hospital, Swansea SA2 8QA, UK. Kelley MR; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA. TeeAR; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
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Źródło:
Cancers [Cancers (Basel)] 2022 Dec 15; Vol. 14 (24). Date of Electronic Publication: 2022 Dec 15.
The zinc finger/RING domain protein Unkempt regulates cognitive flexibility.
Autorzy:
Vinsland E; Maurice Wohl Clinical Neuroscience Institute, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK.; Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solnavägen 9, 17177, Stockholm, Sweden. Baskaran P; Maurice Wohl Clinical Neuroscience Institute, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK. Mihaylov SR; Maurice Wohl Clinical Neuroscience Institute, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK. Hobbs C; Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London, SE1 1UL, UK. Wood H; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, 16 De Crespigny Park, London, PO82SE5 8AF, UK. Bouybayoune I; Centre for Developmental Neurobiology and MRC Centre for Neurodevelopmental Disorders, King's College London, New Hunt's House, Guy's Campus, London, SE1 1UL, UK. Shah K; Department of Biochemistry, University of California, Riverside, 3401 Watkins Drive, Boyce Hall 1415A - MURN, Riverside, CA, 92521, USA. Houart C; Centre for Developmental Neurobiology and MRC Centre for Neurodevelopmental Disorders, King's College London, New Hunt's House, Guy's Campus, London, SE1 1UL, UK. TeeAR; Cancer and Genetics Building, Division of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park Way, Cardiff, CF14 4XN, UK. Murn J; Department of Biochemistry, University of California, Riverside, 3401 Watkins Drive, Boyce Hall 1415A - MURN, Riverside, CA, 92521, USA. Fernandes C; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, 16 De Crespigny Park, London, PO82SE5 8AF, UK.; MRC Centre for Neurodevelopmental Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 4th Floor, New Hunt's House, London, SE1 1UL, UK. Bateman JM; Maurice Wohl Clinical Neuroscience Institute, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK. joseph_.
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Źródło:
Scientific reports [Sci Rep] 2021 Aug 11; Vol. 11 (1), pp. 16299. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Distinctive Features of Orbital Adipose Tissue (OAT) in Graves' Orbitopathy.
Autorzy:
Zhang L; School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Evans A; School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. von Ruhland C; School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Draman MS; School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Edkins S; School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Vincent AE; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle NE2 4HH, UK. Berlinguer-Palmini R; The Bio-Imaging Unit, Faculty of Medical Sciences, Newcastle University, Newcastle NE2 4HH, UK. Rees DA; School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Haridas AS; Department of Ophthalmology, Cardiff & Vale University Health Board, Cardiff CF14 4XW, UK. Morris D; Department of Ophthalmology, Cardiff & Vale University Health Board, Cardiff CF14 4XW, UK. TeeAR; School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Ludgate M; School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Turnbull DM; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle NE2 4HH, UK. Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.; NIHR Oxford Biomedical Research Center, OUH Foundation Trust, Oxford OX4 2PG, UK. Dayan CM; School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Energy Stress-Mediated Cytotoxicity in Tuberous Sclerosis Complex 2-Deficient Cells with Nelfinavir and Mefloquine Treatment.
Autorzy:
McCann HD; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. . Johnson CE; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. . Errington RJ; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. . Davies DM; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. .; Department of Oncology, South West Wales Cancer Centre, Singleton Hospital, Swansea SA2 8QA, UK. . Dunlop EA; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. . TeeAR; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. .
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Źródło:
Cancers [Cancers (Basel)] 2018 Oct 10; Vol. 10 (10). Date of Electronic Publication: 2018 Oct 10.
Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting.
Autorzy:
Murray JT; School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. . TeeAR; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. .
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Źródło:
Cancers [Cancers (Basel)] 2018 May 30; Vol. 10 (6). Date of Electronic Publication: 2018 May 30.
Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression.
Autorzy:
Rad E; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. .; School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. . Murray JT; School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. . TeeAR; Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. .
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Źródło:
Cancers [Cancers (Basel)] 2018 Jan 03; Vol. 10 (1). Date of Electronic Publication: 2018 Jan 03.
mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3.
Autorzy:
Dodd KM; Institute of Cancer and Genetics, Cardiff University, Cardiff, UK. Yang J; Institute of Cancer and Genetics, Cardiff University, Cardiff, UK. Shen MH; Institute of Cancer and Genetics, Cardiff University, Cardiff, UK. Sampson JR; Institute of Cancer and Genetics, Cardiff University, Cardiff, UK. TeeAR; Institute of Cancer and Genetics, Cardiff University, Cardiff, UK.
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Źródło:
Oncogene [Oncogene] 2015 Apr 23; Vol. 34 (17), pp. 2239-50. Date of Electronic Publication: 2014 Jun 16.
Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility.
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