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    Tytuł:
    Treatment failure patterns are similar between p16- and p16+ oropharyngeal squamous cell carcinomas.
    Autorzy:
    Hamill CS; Department of Otolaryngology-Head and Neck Surgery University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine Cleveland Ohio USA.
    Muller RG; Department of Otolaryngology-Head and Neck Surgery University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine Cleveland Ohio USA.
    Clancy K; Department of Otolaryngology-Head and Neck Surgery University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine Cleveland Ohio USA.
    Vu B; University Hospitals Seidman Cancer Center Cleveland Ohio USA.
    Gui S; University Hospitals Seidman Cancer Center Cleveland Ohio USA.
    Thuener JE; Department of Otolaryngology-Head and Neck Surgery University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine Cleveland Ohio USA.; University Hospitals Seidman Cancer Center Cleveland Ohio USA.
    Wasman J; University Hospitals Seidman Cancer Center Cleveland Ohio USA.; Department of Pathology University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine Cleveland Ohio USA.
    Li S; Department of Otolaryngology-Head and Neck Surgery University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine Cleveland Ohio USA.; University Hospitals Seidman Cancer Center Cleveland Ohio USA.
    Fowler N; Department of Otolaryngology-Head and Neck Surgery University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine Cleveland Ohio USA.; University Hospitals Seidman Cancer Center Cleveland Ohio USA.
    Rezaee R; Department of Otolaryngology-Head and Neck Surgery University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine Cleveland Ohio USA.; University Hospitals Seidman Cancer Center Cleveland Ohio USA.
    Lavertu P; Department of Otolaryngology-Head and Neck Surgery University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine Cleveland Ohio USA.; University Hospitals Seidman Cancer Center Cleveland Ohio USA.
    Teknos TN; Department of Otolaryngology-Head and Neck Surgery University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine Cleveland Ohio USA.; University Hospitals Seidman Cancer Center Cleveland Ohio USA.; Case Comprehensive Cancer Center Case Western Reserve University School of Medicine Cleveland Ohio USA.
    Pan Q; Department of Otolaryngology-Head and Neck Surgery University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine Cleveland Ohio USA.; University Hospitals Seidman Cancer Center Cleveland Ohio USA.; Case Comprehensive Cancer Center Case Western Reserve University School of Medicine Cleveland Ohio USA.
    O'Neill WQ; Department of Otolaryngology-Head and Neck Surgery University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine Cleveland Ohio USA.; University Hospitals Seidman Cancer Center Cleveland Ohio USA.
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    Źródło:
    Laryngoscope investigative otolaryngology [Laryngoscope Investig Otolaryngol] 2022 Jun 01; Vol. 7 (4), pp. 988-993. Date of Electronic Publication: 2022 Jun 01 (Print Publication: 2022).
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Repositioning Fenofibrate to Reactivate p53 and Reprogram the Tumor-Immune Microenvironment in HPV+ Head and Neck Squamous Cell Carcinoma.
    Autorzy:
    O'Neill WQ; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.; Department of Otolaryngology-Head and Neck Surgery, University Hospitals, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Xie X; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
    Gui S; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.
    Yu H; Department of Otolaryngology-Head and Neck Surgery, University Hospitals, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Davenport J; Department of Otolaryngology-Head and Neck Surgery, University Hospitals, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Cartwright T; Department of Otolaryngology-Head and Neck Surgery, University Hospitals, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Storl-Desmond M; Department of Otolaryngology-Head and Neck Surgery, University Hospitals, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Ryu E; Department of Otolaryngology-Head and Neck Surgery, University Hospitals, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Chan ER; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Cao S; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Fu P; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Teknos TN; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.; Department of Otolaryngology-Head and Neck Surgery, University Hospitals, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Pan Q; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.; Department of Otolaryngology-Head and Neck Surgery, University Hospitals, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
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    Źródło:
    Cancers [Cancers (Basel)] 2022 Jan 07; Vol. 14 (2). Date of Electronic Publication: 2022 Jan 07.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Impact of p16 Status and Anatomical Site in Anti-PD-1 Immunotherapy-Treated Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma Patients.
    Autorzy:
    Clancy K; Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Hamill CS; Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    O'Neill WQ; Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.
    Vu B; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.
    Thuener J; Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.
    Gui S; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.
    Li S; Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.
    Fowler N; Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.
    Rezaee R; Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.
    Lavertu P; Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.
    Wasman J; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.; Department of Pathology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Patel M; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.; Department of Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Shaikh H; Department of Internal Medicine, Division of Hematology/Oncology, University of Cincinnati, Cincinnati, OH 45267, USA.
    Vick E; Department of Internal Medicine, Division of Hematology/Oncology, University of Cincinnati, Cincinnati, OH 45267, USA.
    Madabhushi A; Department of Biomedical Engineering, Case Western University School of Engineering, Cleveland, OH 44106, USA.; Louis Stokes Cleveland Veterans Administration Medical Center, Cleveland, OH 44106, USA.; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Wise-Draper TM; Department of Internal Medicine, Division of Hematology/Oncology, University of Cincinnati, Cincinnati, OH 45267, USA.
    Burkitt K; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.; Department of Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Teknos TN; Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
    Pan Q; Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA.; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
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    Źródło:
    Cancers [Cancers (Basel)] 2021 Sep 28; Vol. 13 (19). Date of Electronic Publication: 2021 Sep 28.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    p53 functional states are associated with distinct aldehyde dehydrogenase transcriptomic signatures.
    Autorzy:
    Gui S; University Hospitals Seidman Cancer Center, Cleveland, OH, 44106, USA.; Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
    Xie X; Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
    O'Neill WQ; University Hospitals Seidman Cancer Center, Cleveland, OH, 44106, USA.; Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
    Chatfield-Reed K; University Hospitals Seidman Cancer Center, Cleveland, OH, 44106, USA.; Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
    Yu JG; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
    Teknos TN; University Hospitals Seidman Cancer Center, Cleveland, OH, 44106, USA.; Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.; Case Comprehensive Cancer Center, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
    Pan Q; University Hospitals Seidman Cancer Center, Cleveland, OH, 44106, USA. .; Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA. .; Case Comprehensive Cancer Center, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA. .
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    Źródło:
    Scientific reports [Sci Rep] 2020 Jan 23; Vol. 10 (1), pp. 1097. Date of Electronic Publication: 2020 Jan 23.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Aldehyde Dehydrogenase/*genetics
    Papillomavirus Infections/*metabolism
    Tumor Suppressor Protein p53/*metabolism
    Aldehyde Dehydrogenase/metabolism ; Animals ; Female ; Human papillomavirus 16/genetics ; Human papillomavirus 16/physiology ; Humans ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Mice ; Neoplastic Stem Cells/metabolism ; Oncogene Proteins, Viral/genetics ; Oncogene Proteins, Viral/metabolism ; Papillomavirus Infections/enzymology ; Papillomavirus Infections/genetics ; Papillomavirus Infections/virology ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Transcriptome ; Tumor Suppressor Protein p53/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours.
    Autorzy:
    Golias T; Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, 84505, Slovak Republic.
    Papandreou I; Department of Radiation Oncology, Ohio State University Comprehensive Cancer Center and Wexner Medical Center, Columbus OH 43210, USA.
    Sun R; Department of Radiation Oncology, Ohio State University Comprehensive Cancer Center and Wexner Medical Center, Columbus OH 43210, USA.
    Kumar B; Department of Otolaryngology, Ohio State University Comprehensive Cancer Center and Wexner Medical Center, Columbus OH 43210, USA.
    Brown NV; Department of Biomedical Informatics, Center for Biostatistics, Ohio State University Comprehensive Cancer Center and Wexner Medical Center, Columbus OH 43210, USA.
    Swanson BJ; Department of Pathology, Ohio State University Comprehensive Cancer Center and Wexner Medical Center, Columbus OH 43210, USA.
    Pai R; Department of Pathology, University of Pittsburg, Pittsburg PA 15213, USA.
    Jaitin D; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
    Le QT; Department of Radiation Oncology, Stanford University School of Medicine, Stanford CA 94305, USA.
    Teknos TN; Department of Otolaryngology, Ohio State University Comprehensive Cancer Center and Wexner Medical Center, Columbus OH 43210, USA.
    Denko NC; Department of Radiation Oncology, Ohio State University Comprehensive Cancer Center and Wexner Medical Center, Columbus OH 43210, USA.
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    Źródło:
    Scientific reports [Sci Rep] 2016 Aug 08; Vol. 6, pp. 31146. Date of Electronic Publication: 2016 Aug 08.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Neoplasm Proteins/*metabolism
    Neoplasms, Experimental/*enzymology
    Pancreatic Neoplasms/*enzymology
    Pyruvate Dehydrogenase Complex/*metabolism
    Animals ; Cell Hypoxia ; Cell Line, Tumor ; Female ; Humans ; Mice ; Mice, Nude ; Neoplasms, Experimental/pathology ; Pancreatic Neoplasms/pathology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Tumor-Associated Endothelial Cells Promote Tumor Metastasis by Chaperoning Circulating Tumor Cells and Protecting Them from Anoikis.
    Autorzy:
    Yadav A; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States of America.
    Kumar B; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States of America; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, 43210, United States of America.
    Yu JG; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States of America.
    Old M; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States of America; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, 43210, United States of America.
    Teknos TN; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States of America; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, 43210, United States of America.
    Kumar P; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, United States of America; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, 43210, United States of America.
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    Źródło:
    PloS one [PLoS One] 2015 Oct 28; Vol. 10 (10), pp. e0141602. Date of Electronic Publication: 2015 Oct 28 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Anoikis*
    Cell Communication*
    Endothelial Cells/*metabolism
    Neoplasms/*metabolism
    Neoplasms/*pathology
    Neoplastic Cells, Circulating/*metabolism
    Animals ; Cells, Cultured ; Coculture Techniques ; Disease Models, Animal ; E-Selectin/genetics ; E-Selectin/metabolism ; Focal Adhesion Protein-Tyrosine Kinases/metabolism ; Gene Expression ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Heterografts ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/secondary ; Mice ; Neoplasm Metastasis ; Neoplasms/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Signal Transduction ; src-Family Kinases/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The impact of cancer treatment on the diets and food preferences of patients receiving outpatient treatment.
    Autorzy:
    Coa KI; a Bloomberg School of Public Health , Johns Hopkins University , Baltimore , Maryland , USA.
    Epstein JB
    Ettinger D
    Jatoi A
    McManus K
    Platek ME
    Price W
    Stewart M
    Teknos TN
    Moskowitz B
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    Źródło:
    Nutrition and cancer [Nutr Cancer] 2015; Vol. 67 (2), pp. 339-53. Date of Electronic Publication: 2015 Feb 09.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Feeding Behavior/*drug effects
    Food Preferences/*drug effects
    Neoplasms/*drug therapy
    Adult ; Aged ; Appetite/drug effects ; Cross-Sectional Studies ; Diet ; Female ; Humans ; Male ; Middle Aged ; Outpatients ; Quality of Life ; Smell/drug effects ; Surveys and Questionnaires ; Taste/drug effects ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Phosphorylation of Nanog is essential to regulate Bmi1 and promote tumorigenesis.
    Autorzy:
    Xie X; 1] Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA [2] Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
    Piao L; 1] Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA [2] Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
    Cavey GS; 1] Van Andel Research Institute, Grand Rapids, MI, USA [2] Southwest Michigan Innovation Center, Kalamazoo, MI, USA.
    Old M; 1] Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA [2] Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
    Teknos TN; 1] Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA [2] Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
    Mapp AK; Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.
    Pan Q; 1] Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA [2] Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
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    Źródło:
    Oncogene [Oncogene] 2014 Apr 17; Vol. 33 (16), pp. 2040-52. Date of Electronic Publication: 2013 May 27.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gene Expression Regulation, Neoplastic*
    Cell Transformation, Neoplastic/*genetics
    Homeodomain Proteins/*genetics
    Polycomb Repressive Complex 1/*genetics
    Animals ; Base Sequence ; Binding Sites/genetics ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; HEK293 Cells ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Homeodomain Proteins/metabolism ; Humans ; Immunoblotting ; Mass Spectrometry ; Mice ; Mice, Nude ; Mutation ; Nanog Homeobox Protein ; Phosphorylation ; Polycomb Repressive Complex 1/metabolism ; Promoter Regions, Genetic/genetics ; Protein Kinase C-epsilon/genetics ; Protein Kinase C-epsilon/metabolism ; Threonine/genetics ; Threonine/metabolism ; Transplantation, Heterologous
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    A novel curcumin analog (H-4073) enhances the therapeutic efficacy of cisplatin treatment in head and neck cancer.
    Autorzy:
    Kumar B; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, United States of America; The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America.
    Yadav A; The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America.
    Hideg K; Institute of Organic and Medicinal Chemistry, University of Pécs, Pécs, Hungary.
    Kuppusamy P; Geisel School of Medicine, Dartmouth, Hanover, New Hampshire, United States of America.
    Teknos TN; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, United States of America; The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America.
    Kumar P; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, United States of America; The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America.
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    Źródło:
    PloS one [PLoS One] 2014 Mar 27; Vol. 9 (3), pp. e93208. Date of Electronic Publication: 2014 Mar 27 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antineoplastic Agents/*pharmacology
    Cisplatin/*pharmacology
    Curcumin/*pharmacology
    Head and Neck Neoplasms/*pathology
    Animals ; Antineoplastic Agents/administration & dosage ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cisplatin/administration & dosage ; Disease Models, Animal ; Drug Resistance, Neoplasm ; Drug Synergism ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/metabolism ; Humans ; Mice ; Neovascularization, Pathologic/drug therapy ; Phosphorylation ; STAT3 Transcription Factor/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Xenograft Model Antitumor Assays
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma.
    Autorzy:
    Xie X; 1] Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA [2] Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
    Piao L; 1] Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA [2] Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
    Bullock BN; Department of Chemistry, New York University, New York, NY, USA.
    Smith A; 1] Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA [2] Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
    Su T; 1] Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA [2] Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
    Zhang M; 1] Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA [2] Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
    Teknos TN; 1] Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA [2] Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
    Arora PS; Department of Chemistry, New York University, New York, NY, USA.
    Pan Q; 1] Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA [2] Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
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    Źródło:
    Oncogene [Oncogene] 2014 Feb 20; Vol. 33 (8), pp. 1037-46. Date of Electronic Publication: 2013 Mar 11.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Alphapapillomavirus/*isolation & purification
    Carcinoma, Squamous Cell/*metabolism
    Head and Neck Neoplasms/*metabolism
    Oncogene Proteins, Viral/*metabolism
    Repressor Proteins/*metabolism
    Tumor Suppressor Protein p53/*metabolism
    p300-CBP Transcription Factors/*metabolism
    Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/virology ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/virology ; Humans
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    RhoC regulates cancer stem cells in head and neck squamous cell carcinoma by overexpressing IL-6 and phosphorylation of STAT3.
    Autorzy:
    Islam M; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America ; Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.
    Sharma S; Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.
    Teknos TN; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America ; Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.
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    Źródło:
    PloS one [PLoS One] 2014 Feb 12; Vol. 9 (2), pp. e88527. Date of Electronic Publication: 2014 Feb 12 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gene Expression Regulation, Neoplastic*
    Carcinoma, Squamous Cell/*metabolism
    Head and Neck Neoplasms/*metabolism
    Interleukin-6/*metabolism
    Neoplastic Stem Cells/*metabolism
    STAT3 Transcription Factor/*metabolism
    rho GTP-Binding Proteins/*metabolism
    Aldehyde Dehydrogenase 1 Family ; Cell Line, Tumor ; Guanosine Triphosphate/chemistry ; Humans ; Hyaluronan Receptors/metabolism ; Isoenzymes/metabolism ; Phosphorylation ; RNA, Small Interfering/metabolism ; Retinal Dehydrogenase/metabolism ; Signal Transduction ; Transcription Factors/metabolism ; rhoC GTP-Binding Protein
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    PKC ε Phosphorylates and Mediates the Cell Membrane Localization of RhoA.
    Autorzy:
    Su T; Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA ; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
    Straight S
    Bao L
    Xie X
    Lehner CL
    Cavey GS
    Teknos TN
    Pan Q
    Pokaż więcej
    Źródło:
    ISRN oncology [ISRN Oncol] 2013 Sep 29; Vol. 2013, pp. 329063. Date of Electronic Publication: 2013 Sep 29 (Print Publication: 2013).
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    microRNA-107 functions as a candidate tumor-suppressor gene in head and neck squamous cell carcinoma by downregulation of protein kinase Cɛ.
    Autorzy:
    Datta J; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA.
    Smith A
    Lang JC
    Islam M
    Dutt D
    Teknos TN
    Pan Q
    Pokaż więcej
    Źródło:
    Oncogene [Oncogene] 2012 Sep 06; Vol. 31 (36), pp. 4045-53. Date of Electronic Publication: 2011 Dec 12.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gene Expression Regulation, Neoplastic*
    Genes, Tumor Suppressor*
    Carcinoma, Squamous Cell/*genetics
    Head and Neck Neoplasms/*genetics
    MicroRNAs/*physiology
    Protein Kinase C-epsilon/*genetics
    Animals ; Base Sequence ; Carcinoma, Squamous Cell/enzymology ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Cell Transformation, Neoplastic ; Down-Regulation ; Head and Neck Neoplasms/enzymology ; Head and Neck Neoplasms/pathology ; Humans ; Mice ; Mice, Nude ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasm Invasiveness ; Neoplasm Transplantation ; Protein Kinase C-epsilon/metabolism ; Tumor Burden
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Multiparameter analysis, including EMT markers, on negatively enriched blood samples from patients with squamous cell carcinoma of the head and neck.
    Autorzy:
    Balasubramanian P; William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, United States of America.
    Lang JC
    Jatana KR
    Miller B
    Ozer E
    Old M
    Schuller DE
    Agrawal A
    Teknos TN
    Summers TA Jr
    Lustberg MB
    Zborowski M
    Chalmers JJ
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2012; Vol. 7 (7), pp. e42048. Date of Electronic Publication: 2012 Jul 26.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Epithelial-Mesenchymal Transition*
    Biomarkers, Tumor/*metabolism
    Carcinoma, Squamous Cell/*blood
    Carcinoma, Squamous Cell/*pathology
    Head and Neck Neoplasms/*blood
    Head and Neck Neoplasms/*pathology
    Neoplastic Cells, Circulating/*pathology
    Adult ; Aged ; Antigens, Neoplasm/metabolism ; Carcinoma, Squamous Cell/metabolism ; Cell Adhesion Molecules/metabolism ; Cell Line, Tumor ; Epithelial Cell Adhesion Molecule ; Female ; Head and Neck Neoplasms/metabolism ; Humans ; Leukocyte Common Antigens/metabolism ; Male ; Middle Aged
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Dysregulation of microRNA-34a expression in head and neck squamous cell carcinoma promotes tumor growth and tumor angiogenesis.
    Autorzy:
    Kumar B; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, United States of America.
    Yadav A
    Lang J
    Teknos TN
    Kumar P
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2012; Vol. 7 (5), pp. e37601. Date of Electronic Publication: 2012 May 22.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Carcinoma, Squamous Cell/*genetics
    Cell Transformation, Neoplastic/*genetics
    Head and Neck Neoplasms/*genetics
    MicroRNAs/*genetics
    Neovascularization, Pathologic/*genetics
    Animals ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Cell Proliferation ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Down-Regulation ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Humans ; Inhibitor of Apoptosis Proteins/genetics ; Inhibitor of Apoptosis Proteins/metabolism ; Mice ; MicroRNAs/metabolism ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/pathology ; Survivin
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis.
    Autorzy:
    Kumar P; Department of Otolaryngology-Head and Neck Surgery and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA. />Yadav A
    Patel SN
    Islam M
    Pan Q
    Merajver SD
    Teknos TN
    Pokaż więcej
    Źródło:
    Molecular cancer [Mol Cancer] 2010 Aug 03; Vol. 9, pp. 206. Date of Electronic Publication: 2010 Aug 03.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Anoikis*
    Angiogenesis Inhibitors/*pharmacology
    Carcinoma, Squamous Cell/*pathology
    Head and Neck Neoplasms/*prevention & control
    Molybdenum/*pharmacology
    Neoplasm Invasiveness/*prevention & control
    Neoplasm Metastasis/*prevention & control
    Cells, Cultured ; Head and Neck Neoplasms/pathology ; Humans
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-32 z 32

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