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Wyszukujesz frazę ""Telomerase"" wg kryterium: Temat


Tytuł :
The influence of TERC, TERT and ACYP2 genes polymorphisms on plasma telomerase concentration, telomeres length and T2DM.
Autorzy :
AlDehaini DMB; Department of Biochemistry, College of Medicine and Medical Sciences (CMMS), Arabian Gulf University (AGU), Manama, Bahrain; Farwaniya Hospital, Biochemistry Laboratory, PO Box 13373, Farwaniya 81004, Kuwait.
Al-Bustan SA; Department of Biological Sciences, Faculty of Science, Kuwait University, Kuwait City, Kuwait.
Malalla ZHA; Department of Biochemistry, College of Medicine and Medical Sciences (CMMS), Arabian Gulf University (AGU), Manama, Bahrain.
Ali ME; Department of Biochemistry, College of Medicine and Medical Sciences (CMMS), Arabian Gulf University (AGU), Manama, Bahrain.
Sater M; Department of Biochemistry, College of Medicine and Medical Sciences (CMMS), Arabian Gulf University (AGU), Manama, Bahrain.
Giha HA; Department of Biochemistry, College of Medicine and Medical Sciences (CMMS), Arabian Gulf University (AGU), Manama, Bahrain. Electronic address: .
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Źródło :
Gene [Gene] 2021 Jan 15; Vol. 766, pp. 145127. Date of Electronic Publication: 2020 Sep 13.
Typ publikacji :
Journal Article
MeSH Terms :
Acid Anhydride Hydrolases/*genetics
Diabetes Mellitus, Type 2/*genetics
Polymorphism, Single Nucleotide/*genetics
RNA/*genetics
Telomerase/*genetics
Telomere Shortening/*genetics
Adult ; Aged ; Aged, 80 and over ; Alleles ; Female ; Genetic Predisposition to Disease/genetics ; Genotype ; Humans ; Male ; Middle Aged ; Telomerase/blood
Czasopismo naukowe
Tytuł :
[A concise review of telomere and telomerase-related genetic markers in fibrotic lung diseases].
Autorzy :
Fan YL; Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Ye Q; Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
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Źródło :
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases [Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi] 2020 Dec 20; Vol. 38 (12), pp. 952-956.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Idiopathic Pulmonary Fibrosis*/genetics
Telomerase*/genetics
Aged ; Genetic Markers ; Humans ; Telomere/genetics ; Telomere Shortening
Czasopismo naukowe
Tytuł :
DSC and DCE Histogram Analyses of Glioma Biomarkers, Including IDH, MGMT, and TERT, on Differentiation and Survival.
Autorzy :
Zhang HW; Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen 518035, China.
Lyu GW; Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen 518035, China.
He WJ; Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen 518035, China.
Lei Y; Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen 518035, China. Electronic address: .
Lin F; Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen 518035, China.
Wang MZ; Department of MR Scientific Marketing, Siemens Healthineers, Guangzhou, Guangdong Province, China.
Zhang H; Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen 518035, China.
Liang LH; Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen 518035, China.
Feng YN; Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen 518035, China.
Yang JH; Department of Neurosurgery, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, Shenzhen, China.
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Źródło :
Academic radiology [Acad Radiol] 2020 Dec; Vol. 27 (12), pp. e263-e271. Date of Electronic Publication: 2020 Jan 23.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Neoplasms*/diagnostic imaging
Glioma*/diagnostic imaging
Telomerase*
Biomarkers ; Contrast Media ; DNA Modification Methylases/genetics ; DNA Repair Enzymes/genetics ; Humans ; Isocitrate Dehydrogenase/genetics ; Magnetic Resonance Imaging ; Neoplasm Grading ; Tumor Suppressor Proteins
Czasopismo naukowe
Tytuł :
Low level expression of human telomerase reverse transcriptase predicts cancer-related death and progression in embryonal carcinoma.
Autorzy :
Shahin M; Department of Pathology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Saeednejad Zanjani L; Oncopathology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Abolhasani M; Department of Pathology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.; Oncopathology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.; Hasheminejad Kidney Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Rahbar M; Department of Pathology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Asgari M; Department of Pathology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.; Oncopathology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.; Hasheminejad Kidney Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Madjd Z; Department of Pathology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. .; Oncopathology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran. .; Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2020 Nov; Vol. 146 (11), pp. 2753-2775. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*metabolism
Carcinoma, Embryonal/*enzymology
Telomerase/*metabolism
Testicular Neoplasms/*enzymology
Adolescent ; Adult ; Biomarkers, Tumor/analysis ; Carcinoma, Embryonal/mortality ; Carcinoma, Embryonal/pathology ; Disease Progression ; Humans ; Male ; Middle Aged ; Progression-Free Survival ; Telomerase/analysis ; Testicular Neoplasms/mortality ; Testicular Neoplasms/pathology ; Young Adult
Czasopismo naukowe
Tytuł :
Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs.
Autorzy :
Sanford SL; Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health and UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Welfer GA; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, USA.
Freudenthal BD; Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, USA.
Opresko PL; Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health and UPMC Hillman Cancer Center, Pittsburgh, PA, USA. .; Center for Nucleic Acids Science and Technology, Carnegie Mellon University, Pittsburgh, PA, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 20; Vol. 11 (1), pp. 5288. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Enzyme Inhibitors/*metabolism
Telomerase/*antagonists & inhibitors
Telomerase/*metabolism
Deoxyadenine Nucleotides/chemistry ; Deoxyadenine Nucleotides/metabolism ; Deoxyguanine Nucleotides/chemistry ; Deoxyguanine Nucleotides/metabolism ; Enzyme Inhibitors/chemistry ; Humans ; Kinetics ; Models, Molecular ; Oxidation-Reduction ; Telomerase/chemistry ; Telomerase/genetics ; Telomere/metabolism
Czasopismo naukowe
Tytuł :
The secrets of telomerase: Retrospective analysis and future prospects.
Autorzy :
Kamal S; Department of Biochemistry, Government College University Faisalabad, Pakistan.
Junaid M; Department of Biochemistry, Government College University Faisalabad, Pakistan.
Ejaz A; Department of Biochemistry, Government College University Faisalabad, Pakistan.
Bibi I; Department of Chemistry, Islamia University, Bahawalpur, Pakistan.
Akash MSH; Department of Pharmaceutical Chemistry, Government College University Faisalabad, Pakistan. Electronic address: .
Rehman K; Department of Pharmacy, University of Agriculture, Faisalabad, Pakistan. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Sep 15; Vol. 257, pp. 118115. Date of Electronic Publication: 2020 Jul 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Telomerase/*metabolism
Aging/metabolism ; Animals ; Diabetes Mellitus/enzymology ; Humans ; Neoplasms/enzymology ; Telomerase/antagonists & inhibitors ; Telomerase/physiology ; Telomere Shortening
Czasopismo naukowe
Tytuł :
Small Molecules Restore Telomeres in Patient Stem Cells.
Autorzy :
Brenner KA; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Nandakumar J; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: .
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Źródło :
Trends in pharmacological sciences [Trends Pharmacol Sci] 2020 Aug; Vol. 41 (8), pp. 506-508. Date of Electronic Publication: 2020 May 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Dyskeratosis Congenita*
Telomerase*/genetics
Telomerase*/metabolism
Humans ; RNA ; Stem Cells/metabolism ; Telomere/metabolism
Czasopismo naukowe
Tytuł :
Specific suppression of D-RNA G-quadruplex-protein interaction with an L-RNA aptamer.
Autorzy :
Umar MI; Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, China.
Kwok CK; Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong SAR, China.; Shenzhen Research Institute of City University of Hong Kong, Shenzhen, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10125-10141.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
G-Quadruplexes*
RNA*/chemistry
RNA*/metabolism
Telomerase*/chemistry
Telomerase*/metabolism
Aptamers, Nucleotide/*chemistry
Aptamers, Nucleotide/*metabolism
Phosphoproteins/*metabolism
RNA-Binding Proteins/*metabolism
Aptamers, Nucleotide/chemical synthesis ; Humans ; Protein Binding
Czasopismo naukowe
Tytuł :
RNA-protein interaction mapping via MS2- or Cas13-based APEX targeting.
Autorzy :
Han S; Department of Genetics, Chan Zuckerberg Biohub, Stanford University, Stanford, CA 94305.; Department of Biology, Chan Zuckerberg Biohub, Stanford University, Stanford, CA 94305.; Department of Chemistry, Chan Zuckerberg Biohub, Stanford University, Stanford, CA 94305.
Zhao BS; Department of Genetics, Chan Zuckerberg Biohub, Stanford University, Stanford, CA 94305.; Department of Biology, Chan Zuckerberg Biohub, Stanford University, Stanford, CA 94305.; Department of Chemistry, Chan Zuckerberg Biohub, Stanford University, Stanford, CA 94305.
Myers SA; The Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142.
Carr SA; The Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142.
He C; Department of Chemistry, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637.; Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637.
Ting AY; Department of Genetics, Chan Zuckerberg Biohub, Stanford University, Stanford, CA 94305; .; Department of Biology, Chan Zuckerberg Biohub, Stanford University, Stanford, CA 94305.; Department of Chemistry, Chan Zuckerberg Biohub, Stanford University, Stanford, CA 94305.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 08; Vol. 117 (36), pp. 22068-22079. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-(Apurinic or Apyrimidinic Site) Lyase/*metabolism
Endonucleases/*metabolism
Multifunctional Enzymes/*metabolism
Protein Interaction Mapping/*methods
RNA/*metabolism
Telomerase/*metabolism
AlkB Homolog 5, RNA Demethylase/genetics ; AlkB Homolog 5, RNA Demethylase/metabolism ; Biotinylation ; CRISPR-Cas Systems ; DNA Methylation ; DNA-(Apurinic or Apyrimidinic Site) Lyase/genetics ; Endonucleases/genetics ; HEK293 Cells ; Humans ; Mass Spectrometry ; Multifunctional Enzymes/genetics ; Protein Binding ; RNA/genetics ; Telomerase/genetics
Czasopismo naukowe
Tytuł :
6-Dithio-2'-deoxyguanosine analogs induce reactive oxygen species-mediated tumor cell apoptosis via bi-targeting thioredoxin 1 and telomerase.
Autorzy :
Zhang Y; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Zhou J; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Ye Q; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Zeng K; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Pan J; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Chen L; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Wang Y; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Yang B; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
He Q; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Gao J; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Zeng S; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Yu L; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Aug 15; Vol. 401, pp. 115079. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Deoxyguanosine/*administration & dosage
Deoxyguanosine/*analogs & derivatives
Drug Delivery Systems/*methods
Reactive Oxygen Species/*agonists
Telomerase/*antagonists & inhibitors
Thioredoxins/*antagonists & inhibitors
A549 Cells ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Apoptosis/physiology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; HCT116 Cells ; HT29 Cells ; Hep G2 Cells ; Humans ; K562 Cells ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Rats ; Reactive Oxygen Species/metabolism ; Telomerase/metabolism ; Thioredoxins/metabolism
Czasopismo naukowe
Tytuł :
A telomerase-responsive nanoprobe with theranostic properties in tumor cells.
Autorzy :
Zhang HH; Lab of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Zhao LD; Lab of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Zuo P; Lab of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Yin BC; Lab of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China; Institute of Engineering Biology and Health, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 310014, Zhejiang, China; School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, 832000, Xinjiang, China. Electronic address: .
Ye BC; Lab of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China; Institute of Engineering Biology and Health, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 310014, Zhejiang, China; School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, 832000, Xinjiang, China. Electronic address: .
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Źródło :
Talanta [Talanta] 2020 Aug 01; Vol. 215, pp. 120898. Date of Electronic Publication: 2020 Mar 06.
Typ publikacji :
Journal Article
MeSH Terms :
Theranostic Nanomedicine*
Antibiotics, Antineoplastic/*pharmacology
Doxorubicin/*pharmacology
Gold/*pharmacology
Nanoparticles/*chemistry
Oligonucleotides, Antisense/*pharmacology
Telomerase/*metabolism
ATP Binding Cassette Transporter, Subfamily B/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; Antibiotics, Antineoplastic/chemistry ; Antibiotics, Antineoplastic/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Doxorubicin/chemistry ; Doxorubicin/metabolism ; Drug Resistance, Multiple/drug effects ; Drug Screening Assays, Antitumor ; Gold/chemistry ; Gold/metabolism ; Humans ; Oligonucleotides, Antisense/chemistry ; Oligonucleotides, Antisense/metabolism ; Optical Imaging ; Particle Size ; Surface Properties ; Telomerase/chemistry
Czasopismo naukowe
Tytuł :
Noncoding telomeric repeat-containing RNA inhibits the progression of hepatocellular carcinoma by regulating telomerase-mediated telomere length.
Autorzy :
Cao H; State Key Laboratory of Cancer Biology and Department of Physiology and Pathophysiology, Fourth Military Medical University, Xi'an, China.
Zhai Y; Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Ji X; State Key Laboratory of Cancer Biology and Department of Physiology and Pathophysiology, Fourth Military Medical University, Xi'an, China.
Wang Y; State Key Laboratory of Cancer Biology and Department of Physiology and Pathophysiology, Fourth Military Medical University, Xi'an, China.
Zhao J; State Key Laboratory of Cancer Biology and Department of Physiology and Pathophysiology, Fourth Military Medical University, Xi'an, China.
Xing J; State Key Laboratory of Cancer Biology and Department of Physiology and Pathophysiology, Fourth Military Medical University, Xi'an, China.
An J; Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Ren T; State Key Laboratory of Cancer Biology and Experimental, Teaching Center of Basic Medicine, Fourth Military Medical University, Xi'an, China.
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Źródło :
Cancer science [Cancer Sci] 2020 Aug; Vol. 111 (8), pp. 2789-2802. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular/*genetics
Liver Neoplasms/*genetics
RNA, Long Noncoding/*metabolism
Telomerase/*genetics
Telomere/*metabolism
Animals ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Disease ; Disease Progression ; Down-Regulation ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Liver/pathology ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Male ; Mice ; Telomerase/metabolism ; Telomere-Binding Proteins/genetics ; Telomere-Binding Proteins/metabolism ; Telomeric Repeat Binding Protein 2/genetics ; Telomeric Repeat Binding Protein 2/metabolism ; Up-Regulation ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
High voltage electrical injury, early vs. late wound excision, and coverage.
Autorzy :
Ayaz M; Shiraz Burn Research Center, Amiralmomenin Hospital (Burn Center), Department of Surgery, Division of Burn and Reconstructive Surgery, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: .
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Źródło :
Burns : journal of the International Society for Burn Injuries [Burns] 2020 Sep; Vol. 46 (6), pp. 1476-1477. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Letter; Comment
MeSH Terms :
Burns*
Burns, Electric*
Telomerase*
Child ; Humans ; Oxidative Stress
Opinia redakcyjna
Tytuł :
ETS variant transcription factor 5 and c-Myc cooperate in derepressing the human telomerase gene promoter via composite ETS/E-box motifs.
Autorzy :
Zhang F; Department of Pharmaceutical Sciences, Washington State University College of Pharmacy and Pharmaceutical Sciences, Spokane, Washington, USA.
Wang S; Department of Pharmaceutical Sciences, Washington State University College of Pharmacy and Pharmaceutical Sciences, Spokane, Washington, USA.
Zhu J; Department of Pharmaceutical Sciences, Washington State University College of Pharmacy and Pharmaceutical Sciences, Spokane, Washington, USA .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Jul 17; Vol. 295 (29), pp. 10062-10075. Date of Electronic Publication: 2020 Jun 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Enzymologic*
Response Elements*
DNA-Binding Proteins/*metabolism
Proto-Oncogene Proteins c-myc/*metabolism
Telomerase/*biosynthesis
Transcription Factors/*metabolism
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; Cell Line, Tumor ; Cells, Cultured ; DNA-Binding Proteins/genetics ; Humans ; Proto-Oncogene Proteins c-myc/genetics ; Telomerase/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Telomerase activity, TERT expression, hTERT promoter alterations, and alternative lengthening of the telomeres (ALT) in meningiomas - a systematic review.
Autorzy :
Stögbauer L; Department of Neurosurgery, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149, Münster, Germany.
Stummer W; Department of Neurosurgery, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149, Münster, Germany.
Senner V; Institute of Neuropathology, University Hospital Münster, Pottkamp 2, Münster, North Rhine-Westphalia, Germany.
Brokinkel B; Department of Neurosurgery, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149, Münster, Germany. .
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Źródło :
Neurosurgical review [Neurosurg Rev] 2020 Jun; Vol. 43 (3), pp. 903-910. Date of Electronic Publication: 2019 Feb 20.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Brain Neoplasms/*genetics
Meningioma/*genetics
Telomerase/*genetics
Telomerase/*metabolism
Telomere/*genetics
Telomere Homeostasis/*genetics
Brain Neoplasms/ultrastructure ; Humans ; Meningioma/ultrastructure ; Telomerase/biosynthesis ; Telomere/ultrastructure
Czasopismo naukowe
Tytuł :
[Telomerase activity, mTert gene expression and the telomere length in mouse mesenchymal stem cells in the late period after γ- and γ,n-irradiation and in the tumors developed from these cells].
Autorzy :
Vysotskaya OV; NRC Kurchatov Institute, Moscow, Russia.
Glukhov AI; Faculty of Biology, Moscow State University, Moscow, Russia; Sechenov University, Moscow, Russia.
Semochkina YP; NRC Kurchatov Institute, Moscow, Russia.
Gordeev SA; Faculty of Biology, Moscow State University, Moscow, Russia.
Moskaleva EY; NRC Kurchatov Institute, Moscow, Russia.
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Transliterated Title :
Aktivnost' telomerazy, ékspressiia gena mTert i dlina telomer v otdalennyĭ period posle γ- i γ,n-oblucheniia v mezenkhimal'nykh stvolovykh kletkakh myshi i v opukholiakh, obrazovavshikhsia iz étikh kletok.
Źródło :
Biomeditsinskaia khimiia [Biomed Khim] 2020 May; Vol. 66 (3), pp. 265-273.
Typ publikacji :
Journal Article
MeSH Terms :
Gamma Rays*
Mesenchymal Stem Cells*
Telomerase*/genetics
Telomerase*/metabolism
Telomere*/genetics
Animals ; Cell Line ; Fibrosarcoma/pathology ; Mice
Czasopismo naukowe
Tytuł :
Regulation of poly(a)-specific ribonuclease activity by reversible lysine acetylation.
Autorzy :
Dejene EA; Department of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, D.C., USA.; George Washington University Cancer Center, Washington, D.C., USA.
Li Y; Department of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, D.C., USA.; George Washington University Cancer Center, Washington, D.C., USA.
Showkatian Z; Department of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, D.C., USA.; George Washington University Cancer Center, Washington, D.C., USA.
Ling H; Department of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, D.C., USA.; George Washington University Cancer Center, Washington, D.C., USA.
Seto E; Department of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, D.C., USA .; George Washington University Cancer Center, Washington, D.C., USA.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Jul 24; Vol. 295 (30), pp. 10255-10270. Date of Electronic Publication: 2020 May 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Telomere Homeostasis*
Exoribonucleases/*metabolism
Sirtuin 1/*metabolism
Telomerase/*metabolism
Telomere/*metabolism
Acetylation ; Exoribonucleases/genetics ; Gene Knockout Techniques ; HCT116 Cells ; HeLa Cells ; Humans ; Lysine/genetics ; Lysine/metabolism ; Sirtuin 1/genetics ; Telomerase/genetics ; Telomere/genetics
Czasopismo naukowe
Tytuł :
Azidothymidine "Clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors.
Autorzy :
Berrino E; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.
Angeli A; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.
Zhdanov DD; Institute of Biomedical Chemistry, Pogodinskaya st. 10/8, 119121 Moscow, Russia.; Peoples Friendship University of Russia (RUDN University), Miklukho-Maklaya st. 6, 117198 Moscow, Russia.
Kiryukhina AP; Institute of Biomedical Chemistry, Pogodinskaya st. 10/8, 119121 Moscow, Russia.
Milaneschi A; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.
De Luca A; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.
Bozdag M; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.
Carradori S; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Selleri S; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.
Bartolucci G; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.
Peat TS; CSIRO, 343 Royal Parade, Parkville, Victoria 3052, Australia.
Ferraroni M; Dipartimento di Chimica 'Ugo Schiff', Università di Firenze, Via della Lastruccia 3-13, 50019 Sesto Fiorentino (Florence), Italy.
Supuran CT; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.
Carta F; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Jul 09; Vol. 63 (13), pp. 7392-7409. Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*chemistry
Enzyme Inhibitors/*pharmacology
Telomerase/*antagonists & inhibitors
Zidovudine/*chemistry
Carbonic Anhydrase II/antagonists & inhibitors ; Carbonic Anhydrase II/chemistry ; Carbonic Anhydrase II/metabolism ; Carbonic Anhydrase Inhibitors/chemistry ; Carbonic Anhydrase Inhibitors/metabolism ; Carbonic Anhydrase Inhibitors/pharmacology ; Catalytic Domain ; Crystallography, X-Ray ; Cycloaddition Reaction ; Drug Design ; HT29 Cells ; Humans ; PC-3 Cells ; Structure-Activity Relationship ; Telomerase/genetics ; Telomerase/metabolism ; Triazoles/chemistry
Czasopismo naukowe
Tytuł :
Insights into the structure and function of Est3 from the Hansenula polymorpha telomerase.
Autorzy :
Shepelev NM; M.V. Lomonosov Moscow State University, Moscow, 119991, Russia.; Skolkovo Institute of Science and Technology, Moscow, 121205, Russia.
Mariasina SS; M.V. Lomonosov Moscow State University, Moscow, 119991, Russia.; Faculty of Biology and Biotechnology, Higher School of Economics, Moscow, 101000, Russia.
Mantsyzov AB; M.V. Lomonosov Moscow State University, Moscow, 119991, Russia.
Malyavko AN; M.V. Lomonosov Moscow State University, Moscow, 119991, Russia.
Efimov SV; NMR Laboratory, Institute of Physics, Kazan Federal University, Kazan, 420008, Russia.
Petrova OA; M.V. Lomonosov Moscow State University, Moscow, 119991, Russia.
Rodina EV; M.V. Lomonosov Moscow State University, Moscow, 119991, Russia.
Zvereva MI; M.V. Lomonosov Moscow State University, Moscow, 119991, Russia.
Dontsova OA; M.V. Lomonosov Moscow State University, Moscow, 119991, Russia. .; Skolkovo Institute of Science and Technology, Moscow, 121205, Russia. .
Polshakov VI; M.V. Lomonosov Moscow State University, Moscow, 119991, Russia. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 06; Vol. 10 (1), pp. 11109. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fungal Proteins/*chemistry
Pichia/*metabolism
RNA/*chemistry
Saccharomyces cerevisiae Proteins/*chemistry
Telomerase/*metabolism
Catalytic Domain ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Humans ; Pichia/genetics ; Protein Binding ; Protein Conformation ; RNA/genetics ; RNA/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Telomerase/chemistry ; Telomerase/genetics
Czasopismo naukowe

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