Temat: "Telomerase" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Pulmonary Alveolar Stem Cell Senescence, Apoptosis, and Differentiation by p53-Dependent and -Independent Mechanisms in Telomerase-Deficient Mice.
Autorzy:: Zhang K; Institute of Ageing Research, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou 311121, China.
Wang L; Institute of Ageing Research, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou 311121, China.
Hong X; Institute of Ageing Research, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou 311121, China.
Chen H; Institute of Ageing Research, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou 311121, China.
Shi Y; Institute of Ageing Research, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou 311121, China.
Liu Y; Institute of Ageing Research, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou 311121, China.
Liu J; Institute of Ageing Research, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou 311121, China.
Liu JP; Institute of Ageing Research, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou 311121, China.; Hudson Institute of Medical Research and Monash University Department of Molecular and Translational Science, Clayton, VIC 3168, Australia.; Department of Immunology and Pathology, Monash University Faculty of Medicine, Prahran, VIC 3181, Australia.; Pokaż więcej
Źródło:: Cells [Cells] 2021 Oct 26; Vol. 10 (11). Date of Electronic Publication: 2021 Oct 26.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Apoptosis*
Cell Differentiation*
Cellular Senescence*
Alveolar Epithelial Cells/*pathology
Telomerase/*deficiency
Tumor Suppressor Protein p53/*metabolism
Aging/pathology ; Animals ; Caspase 3/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Idiopathic Pulmonary Fibrosis/pathology ; Inflammation/pathology ; Mice, Inbred C57BL ; Mice, Knockout ; Protein Subunits/metabolism ; RNA/metabolism ; Signal Transduction ; Stem Cells/metabolism ; Telomerase/metabolism ; Tumor Suppressor Protein p53/deficiency ; Mice

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Skocz do pozycji: 2.

Tytuł:: Overexpression of Beclin1 gene leads to reduction of telomerase activity in MDCK cells and enhances apoptosis.
Autorzy:: Taji F; Department of Animal Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran.
Abdoli A; Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.
Baesi K; Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.
Sheikholeslami F; WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran.
Kouchesfahani HM; Department of Animal Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran.; Pokaż więcej
Źródło:: Journal of cancer research and therapeutics [J Cancer Res Ther] 2021 Jan-Mar; Vol. 17 (1), pp. 225-230.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*
Autophagy*
Beclin-1/*metabolism
Neoplasms/*pathology
Telomerase/*antagonists & inhibitors
Animals ; Beclin-1/genetics ; Dogs ; Madin Darby Canine Kidney Cells ; Neoplasms/metabolism ; Signal Transduction ; Telomerase/metabolism

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Skocz do pozycji: 3.

Tytuł:: TERT and Akt Are Involved in the Par-4-Dependent Apoptosis of Islet β Cells in Type 2 Diabetes.
Autorzy:: Liu C; Endocrine Department, First Affiliated Hospital of the Third Military Medical University (Army Medical University), Chongqing 400038, China.
QiNan W; Endocrine Department, First Affiliated Hospital of the Third Military Medical University (Army Medical University), Chongqing 400038, China.
XiaoTian L; Endocrine Department, First Affiliated Hospital of the Third Military Medical University (Army Medical University), Chongqing 400038, China.
MengLiu Y; Endocrine Department, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
XiaGuang G; Endocrine Department, First Affiliated Hospital of the Third Military Medical University (Army Medical University), Chongqing 400038, China.
WeiLing L; Endocrine Department, First Affiliated Hospital of the Third Military Medical University (Army Medical University), Chongqing 400038, China.
ZiWen L; Endocrine Department, First Affiliated Hospital of the Third Military Medical University (Army Medical University), Chongqing 400038, China.
Ling Z; Outpatient Department, First Affiliated Hospital of the Third Military Medical University (Army Medical University), Chongqing 400038, China.
GangYi Y; Endocrine Department, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Bing C; Endocrine Department, First Affiliated Hospital of the Third Military Medical University (Army Medical University), Chongqing 400038, China.; Pokaż więcej
Źródło:: Journal of diabetes research [J Diabetes Res] 2018 Aug 14; Vol. 2018, pp. 7653904. Date of Electronic Publication: 2018 Aug 14 (Print Publication: 2018).
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*
Diabetes Mellitus, Experimental/*enzymology
Diabetes Mellitus, Type 2/*enzymology
Insulin-Secreting Cells/*enzymology
Proto-Oncogene Proteins c-akt/*metabolism
Receptors, Thrombin/*metabolism
Telomerase/*metabolism
Active Transport, Cell Nucleus ; Animals ; Blood Glucose/metabolism ; Case-Control Studies ; Cell Line, Tumor ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/pathology ; Humans ; Insulin-Secreting Cells/pathology ; Leucine Zippers ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphorylation ; Protein Binding ; Protein Interaction Domains and Motifs ; Receptors, Thrombin/deficiency ; Receptors, Thrombin/genetics ; Signal Transduction ; Telomerase/blood ; Telomerase/genetics

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Skocz do pozycji: 4.

Tytuł:: Inhibition of telomerase activity and induction of apoptosis by Rhodospirillum rubrum L-asparaginase in cancer Jurkat cell line and normal human CD4+ T lymphocytes.
Autorzy:: Zhdanov DD; Institute of Biomedical Chemistry, Pogodinskaya st., 10/8, Moscow, 119121, Russia.
Pokrovsky VS; Institute of Biomedical Chemistry, Pogodinskaya st., 10/8, Moscow, 119121, Russia.; N.N. Blokhin Cancer Research Center, Kashirskoe Shosse 24, Moscow, 115478, Russia.; Peoples' Friendship, University of Russia, RUDN University, Miklukho-Maklaya st., 6, Moscow, 117198, Russia.
Pokrovskaya MV; Institute of Biomedical Chemistry, Pogodinskaya st., 10/8, Moscow, 119121, Russia.
Alexandrova SS; Institute of Biomedical Chemistry, Pogodinskaya st., 10/8, Moscow, 119121, Russia.
Eldarov MA; Research Center of Biotechnology RAS, Leninsky prospect, 33, Moscow, 119071, Russia.
Grishin DV; Institute of Biomedical Chemistry, Pogodinskaya st., 10/8, Moscow, 119121, Russia.
Basharov MM; Peoples' Friendship, University of Russia, RUDN University, Miklukho-Maklaya st., 6, Moscow, 117198, Russia.
Gladilina YA; Institute of Biomedical Chemistry, Pogodinskaya st., 10/8, Moscow, 119121, Russia.
Podobed OV; Institute of Biomedical Chemistry, Pogodinskaya st., 10/8, Moscow, 119121, Russia.
Sokolov NN; Institute of Biomedical Chemistry, Pogodinskaya st., 10/8, Moscow, 119121, Russia.; Pokaż więcej
Źródło:: Cancer medicine [Cancer Med] 2017 Nov; Vol. 6 (11), pp. 2697-2712. Date of Electronic Publication: 2017 Oct 05.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis/*drug effects
Asparaginase/*pharmacology
Cell Proliferation/*drug effects
Telomerase/*antagonists & inhibitors
Adolescent ; Adult ; CD4-Positive T-Lymphocytes ; Cell Cycle Checkpoints/drug effects ; Cellular Senescence/drug effects ; Dose-Response Relationship, Drug ; Down-Regulation/drug effects ; Humans ; Jurkat Cells ; Telomerase/genetics ; Telomere Shortening/drug effects ; Time Factors ; Young Adult ; beta-Galactosidase/metabolism

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Skocz do pozycji: 5.

Tytuł:: The effects of thymoquinone and genistein treatment on telomerase activity, apoptosis, angiogenesis, and survival in thyroid cancer cell lines.
Autorzy:: Ozturk SA; Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Besevler, Ankara 06500, Turkey.
Alp E; Department of Medical Biology, Faculty of Medicine, Giresun University, Giresun 28200, Turkey.
Yar Saglam AS; Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Besevler, Ankara 06500, Turkey.
Konac E; Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Besevler, Ankara 06500, Turkey.
Menevse ES; Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Besevler, Ankara 06500, Turkey.; Pokaż więcej
Źródło:: Journal of cancer research and therapeutics [J Cancer Res Ther] 2018 Jan-Mar; Vol. 14 (2), pp. 328-334.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Benzoquinones/*pharmacology
Genistein/*pharmacology
Telomerase/*metabolism
Caspase 3/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Enzyme Activation/drug effects ; Gene Expression ; Humans ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Neovascularization, Pathologic/drug therapy ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Telomerase/genetics

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Skocz do pozycji: 6.

Tytuł:: Targeting Telomerase and ATRX/DAXX Inducing Tumor Senescence and Apoptosis in the Malignant Glioma.
Autorzy:: Fan HC; Department of Pediatrics, Department of Medical research, Tungs' Taichung Metroharbor Hospital, Wuchi, Taichung 435, Taiwan. .; Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan. .; Department of Rehabilitation, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 356, Taiwan. .
Chen CM; Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan. .; The iEGG and Animal Biotechnology Center, and Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan. .
Chi CS; Department of Pediatrics, Department of Medical research, Tungs' Taichung Metroharbor Hospital, Wuchi, Taichung 435, Taiwan. .
Tsai JD; School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. .; Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, Taiwan. .
Chiang KL; Department of Pediatric Neurology, Kuang-Tien General Hospital, Taichung 433, Taiwan. .; Department of Nutrition, Hungkuang University, Taichung 433, Taiwan. .
Chang YK; Department of Pediatrics, Department of Medical research, Tungs' Taichung Metroharbor Hospital, Wuchi, Taichung 435, Taiwan. .; Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan. .; Department of Rehabilitation, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 356, Taiwan. .
Lin SZ; Buddhist Tzu Chi Bioinnovation Center, Tzu Chi Foundation, Hualien 970, Taiwan. .; Department of Neurosurgery, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan. .
Harn HJ; Buddhist Tzu Chi Bioinnovation Center, Tzu Chi Foundation, Hualien 970, Taiwan. .; Department of Pathology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien 970, Taiwan. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2019 Jan 08; Vol. 20 (1). Date of Electronic Publication: 2019 Jan 08.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Apoptosis*
Cellular Senescence*
Adaptor Proteins, Signal Transducing/*metabolism
Brain Neoplasms/*pathology
Glioma/*pathology
Telomerase/*metabolism
X-linked Nuclear Protein/*metabolism
Animals ; Humans

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Skocz do pozycji: 7.

Tytuł:: PTEN Inhibits Cell Proliferation, Promotes Cell Apoptosis, and Induces Cell Cycle Arrest via Downregulating the PI3K/AKT/ hTERT Pathway in Lung Adenocarcinoma A549 Cells.
Autorzy:: Lu XX; Department of Geriatrics, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Cao LY; Department of Geriatrics, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Chen X; Department of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Xiao J; Department of Geriatrics, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Zou Y; Department of Geriatrics, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Chen Q; Department of Geriatrics, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.; Pokaż więcej
Źródło:: BioMed research international [Biomed Res Int] 2016; Vol. 2016, pp. 2476842. Date of Electronic Publication: 2016 Oct 16.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*
Cell Cycle Checkpoints*
Down-Regulation*
Gene Expression Regulation, Neoplastic*
Signal Transduction*
Adenocarcinoma/*metabolism
Lung Neoplasms/*metabolism
PTEN Phosphohydrolase/*metabolism
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Telomerase/*metabolism
Adenocarcinoma/drug therapy ; Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Amino Acid Substitution ; Cell Line, Tumor ; Chromones/pharmacology ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Morpholines/pharmacology ; Mutation, Missense ; PTEN Phosphohydrolase/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Telomerase/genetics

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Skocz do pozycji: 8.

Tytuł:: Pro-apoptotic and anti-proliferative effects of 3,3'-diindolylmethane in nasopharyngeal carcinoma cells via downregulation of telomerase activity.
Autorzy:: Li F; Research Institute of Otolaryngology‑Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
Xu Y; Department of Otolaryngology‑Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
Chen C; Research Institute of Otolaryngology‑Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
Chen SM; Department of Otolaryngology‑Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
Xiao BK; Research Institute of Otolaryngology‑Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
Tao ZZ; Research Institute of Otolaryngology‑Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2015 Sep; Vol. 12 (3), pp. 3815-3820. Date of Electronic Publication: 2015 May 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Cell Proliferation/*drug effects
Indoles/*pharmacology
Nasopharyngeal Neoplasms/*drug therapy
Telomerase/*genetics
Cell Line, Tumor ; Down-Regulation/drug effects ; Drug Screening Assays, Antitumor ; Humans ; Telomerase/metabolism ; Telomere Homeostasis/drug effects

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Skocz do pozycji: 9.

Tytuł:: Dose-dependent cytotoxic effects of boldine in HepG-2 cells-telomerase inhibition and apoptosis induction.
Autorzy:: Noureini SK; Deptartment of Biology, Faculty of Basic Sciences, Hakim Sabzevari University, P.O. Box 397, Sabzevar, 9617966376 Iran. .
Wink M; Department of Biology, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF 364, 69120, Heidelberg, Germany. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2015 Feb 24; Vol. 20 (3), pp. 3730-43. Date of Electronic Publication: 2015 Feb 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antioxidants/*pharmacology
Apoptosis/*drug effects
Aporphines/*pharmacology
Carcinoma, Hepatocellular/*pathology
Liver Neoplasms/*pathology
Telomerase/*antagonists & inhibitors
Blotting, Western ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/enzymology ; Cell Proliferation/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; HEK293 Cells ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/enzymology ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Telomerase/genetics ; Telomerase/metabolism

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Skocz do pozycji: 10.

Tytuł:: Effects of bleomycin A5 on caspase-3, P53, bcl-2 expression and telomerase activity in vascular endothelial cells.
Autorzy:: Huang YD; Department of Otorhinolaryngology, The 118 Hospital of Chinese PLA, Wenzhou, Zhejiang 325000, China.
Li P; Department of Otorhinolaryngology, General Hospital of Chengdu Military Region of PLA, Chengdu, Sichuan 610083, China.
Tong X; Department of Otorhinolaryngology, The First Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 325000.
He Y; Department of Otorhinolaryngology, General Hospital of Chengdu Military Region of PLA, Chengdu, Sichuan 610083, China.
Zhuo Y; Department of Otorhinolaryngology, The 118 Hospital of Chinese PLA, Wenzhou, Zhejiang 325000, China.
Xia SW; Department of Otorhinolaryngology, The 118 Hospital of Chinese PLA, Wenzhou, Zhejiang 325000, China.
Luo XH; Department of Otorhinolaryngology, The 118 Hospital of Chinese PLA, Wenzhou, Zhejiang 325000, China.; Pokaż więcej
Źródło:: Indian journal of pharmacology [Indian J Pharmacol] 2015 Jan-Feb; Vol. 47 (1), pp. 55-8.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis/*drug effects
Bleomycin/*analogs & derivatives
Caspase 3/*metabolism
Enzyme Inhibitors/*pharmacology
Human Umbilical Vein Endothelial Cells/*drug effects
Proto-Oncogene Proteins c-bcl-2/*metabolism
Telomerase/*antagonists & inhibitors
Tumor Suppressor Protein p53/*metabolism
Bleomycin/toxicity ; Cells, Cultured ; Dose-Response Relationship, Drug ; Human Umbilical Vein Endothelial Cells/enzymology ; Human Umbilical Vein Endothelial Cells/pathology ; Humans ; Signal Transduction/drug effects ; Telomerase/metabolism ; Up-Regulation

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Skocz do pozycji: 11.

Tytuł:: Downregulation of hTERT: an important As2O3 induced mechanism of apoptosis in myelodysplastic syndrome.
Autorzy:: Xu W; Institute of Hematology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Wang Y; Institute of Hematology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Tong H; Institute of Hematology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Qian W; Institute of Hematology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Jin J; Institute of Hematology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2014 Nov 21; Vol. 9 (11), pp. e113199. Date of Electronic Publication: 2014 Nov 21 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Apoptosis/*drug effects
Arsenicals/*pharmacology
Down-Regulation/*drug effects
Oxides/*pharmacology
Telomerase/*metabolism
Aged ; Arsenic Trioxide ; Blotting, Western ; Caspase 3/metabolism ; Caspase 8/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Child, Preschool ; Down-Regulation/genetics ; Female ; Humans ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/metabolism ; Myelodysplastic Syndromes/pathology ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Poly(ADP-ribose) Polymerases/metabolism ; Protein Binding/drug effects ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Sp1 Transcription Factor/metabolism ; Telomerase/genetics ; Transcription Factor AP-1/metabolism ; X-Linked Inhibitor of Apoptosis Protein/metabolism ; bcl-X Protein/metabolism

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Skocz do pozycji: 12.

Tytuł:: Activated carbon N-acetylcysteine microcapsule protects against nonalcoholic fatty liver disease in young rats via activating telomerase and inhibiting apoptosis.
Autorzy:: Shi T; Department of Pharmaceutical Preparation, The Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Yang X; College of Pharmaceutical Science, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, P.R. China.
Zhou H; Department of Pharmacy, Hangzhou Children's Hospital, Hangzhou, Zhejiang, China.
Xi J; Department of Pharmaceutical Preparation, The Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Sun J; Department of Pharmaceutical Preparation, The Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Ke Y; Department of Pharmaceutical Preparation, The Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Zhang J; Department of Pharmaceutical Preparation, The Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Shao Y; Department of Pharmaceutical Preparation, The Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Jiang X; Department of Pharmaceutical Preparation, The Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Pan X; Department of Pharmaceutical Preparation, The Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Liu S; Department of Pharmaceutical Preparation, The Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Zhuang R; Department of Pharmaceutical Preparation, The Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2018 Jan 11; Vol. 13 (1), pp. e0189856. Date of Electronic Publication: 2018 Jan 11 (Print Publication: 2018).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Acetylcysteine/*pharmacology
Apoptosis/*drug effects
Non-alcoholic Fatty Liver Disease/*prevention & control
Telomerase/*metabolism
Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Enzyme Activation ; Glucose/metabolism ; Glucose Tolerance Test ; Homeostasis ; Male ; Non-alcoholic Fatty Liver Disease/enzymology ; Rats ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction

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Skocz do pozycji: 13.

Tytuł:: Overexpression of human telomerase reverse transcriptase C-terminal polypeptide sensitizes HeLa cells to 5-fluorouracil‑induced growth inhibition and apoptosis.
Autorzy:: Lin G; The Engineering Lab of Synthetic Biology and the Key Lab of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, Guangdong 518060, P.R. China.
Chen Q
Yu S
Lin S
Yao H
Ding Z
Chen S
Lin MC
Wang X; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2014 Jan; Vol. 9 (1), pp. 279-84. Date of Electronic Publication: 2013 Nov 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Fluorouracil/*pharmacology
Peptides/*metabolism
Telomerase/*metabolism
Caspase 3/metabolism ; Caspase 9/metabolism ; Cell Proliferation/drug effects ; HeLa Cells ; Humans ; Peptides/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Telomerase/chemistry ; Telomerase/genetics

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Skocz do pozycji: 14.

Tytuł:: Telomerase inhibition by non-nucleosidic compound BIBR1532 causes rapid cell death in pre-B acute lymphoblastic leukemia cells.
Autorzy:: Bashash D; Department of Hematology, Faculty of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ghaffari SH
Mirzaee R
Alimoghaddam K
Ghavamzadeh A; Pokaż więcej
Źródło:: Leukemia & lymphoma [Leuk Lymphoma] 2013 Mar; Vol. 54 (3), pp. 561-8. Date of Electronic Publication: 2012 Sep 28.
Typ publikacji:: Journal Article
MeSH Terms:: Aminobenzoates/*pharmacology
Apoptosis/*drug effects
Naphthalenes/*pharmacology
Telomerase/*antagonists & inhibitors
Caspase 3/genetics ; Caspase 3/metabolism ; Cell Cycle Checkpoints/drug effects ; Cell Cycle Checkpoints/genetics ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/genetics ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Dose-Response Relationship, Drug ; Gene Expression Regulation, Leukemic/drug effects ; Humans ; Inhibitor of Apoptosis Proteins/genetics ; Inhibitor of Apoptosis Proteins/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Survivin ; Telomerase/genetics ; Telomerase/metabolism ; Tumor Protein p73 ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism

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Skocz do pozycji: 15.

Tytuł:: Effect of evodiamine on the proliferation and apoptosis of A549 human lung cancer cells.
Autorzy:: Lin L; Department of Thoracic Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Lung Cancer Diagnosis and Treatment Center, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, P.R. China.
Ren L; Department of Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, P.R. China.
Wen L; Department of Pharmacy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, P.R. China.
Wang Y; Department of Radiology, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P.R. China.
Qi J; Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2016 Sep; Vol. 14 (3), pp. 2832-8. Date of Electronic Publication: 2016 Jul 29.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Quinazolines/*pharmacology
A549 Cells ; Apoptosis/genetics ; Caspase 3/metabolism ; Caspase 8/metabolism ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Glutathione/metabolism ; Hedgehog Proteins/metabolism ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Plant Extracts/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Telomerase/metabolism

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 16.

Tytuł:: The G-quadruplex ligand, SYUIQ-FM05, targets proto-oncogene c-kit transcription and induces apoptosis in K562 cells.
Autorzy:: Shen FH; Center of Preclinical Screening and Evaluation on New Drug, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China.
Jin J
Li J
Wang Y
Zhu SH
Lu YJ
Ou TM
Huang ZS
Huang M
Huang ZY; Pokaż więcej
Źródło:: Pharmaceutical biology [Pharm Biol] 2013 Apr; Vol. 51 (4), pp. 447-54. Date of Electronic Publication: 2013 Jan 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Diamines/*pharmacology
Enzyme Inhibitors/*pharmacology
G-Quadruplexes/*drug effects
Indoles/*pharmacology
Proto-Oncogene Proteins c-kit/*metabolism
Quinolines/*pharmacology
Quinolinium Compounds/*pharmacology
Telomerase/*antagonists & inhibitors
Transcription, Genetic/*drug effects
Benzamides/pharmacology ; Blotting, Western ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Down-Regulation ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Flow Cytometry ; Humans ; Imatinib Mesylate ; Inhibitory Concentration 50 ; K562 Cells ; Ligands ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Phosphorylation ; Piperazines/pharmacology ; Proto-Oncogene Mas ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-kit/genetics ; Pyrimidines/pharmacology ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Telomerase/metabolism ; bcl-2-Associated X Protein/metabolism

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 17.

Tytuł:: Effects of telomerase activity and apoptosis on ex vivo expansion of cord blood CD34(+) cells.
Autorzy:: Ge J; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Cai H
Li Q
Du Z
Tan WS; Pokaż więcej
Źródło:: Cell proliferation [Cell Prolif] 2013 Feb; Vol. 46 (1), pp. 38-44. Date of Electronic Publication: 2012 Dec 15.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Apoptosis*
Antigens, CD34/*metabolism
Fetal Blood/*cytology
Fetal Blood/*enzymology
Telomerase/*metabolism
Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Fetal Blood/metabolism ; Humans ; RNA, Messenger/metabolism ; Telomerase/genetics