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Wyszukujesz frazę ""Terfenadine"" wg kryterium: Temat


Tytuł :
UPLC-MS/MS method for the simultaneous quantification of pravastatin, fexofenadine, rosuvastatin, and methotrexate in a hepatic uptake model and its application to the possible drug-drug interaction study of triptolide.
Autorzy :
Wu W; New drug screening center, Institute of Pharmaceutical Research, China Pharmaceutical University, Nanjing, China.; Key Laboratory of Drug Quality Control and Pharmacovigilance of Ministry of Education, China Pharmaceutical University, Nanjing, China.
Cheng R; New drug screening center, Institute of Pharmaceutical Research, China Pharmaceutical University, Nanjing, China.; Key Laboratory of Drug Quality Control and Pharmacovigilance of Ministry of Education, China Pharmaceutical University, Nanjing, China.
Jiang Z; New drug screening center, Institute of Pharmaceutical Research, China Pharmaceutical University, Nanjing, China.; Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, China.
Zhang L; Center for Drug Screening and Pharmacodynamics Evaluation, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
Huang X; New drug screening center, Institute of Pharmaceutical Research, China Pharmaceutical University, Nanjing, China.; Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, China.
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Źródło :
Biomedical chromatography : BMC [Biomed Chromatogr] 2021 Jul; Vol. 35 (7), pp. e5093. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article
MeSH Terms :
Methotrexate*/analysis
Methotrexate*/pharmacokinetics
Pravastatin*/analysis
Pravastatin*/pharmacokinetics
Rosuvastatin Calcium*/analysis
Rosuvastatin Calcium*/pharmacokinetics
Hepatocytes/*metabolism
Terfenadine/*analogs & derivatives
Animals ; Cells, Cultured ; Chromatography, High Pressure Liquid/methods ; Diterpenes/analysis ; Diterpenes/pharmacokinetics ; Drug Interactions ; Epoxy Compounds/analysis ; Epoxy Compounds/pharmacokinetics ; Linear Models ; Male ; Phenanthrenes/analysis ; Phenanthrenes/pharmacokinetics ; Rats, Wistar ; Reproducibility of Results ; Sensitivity and Specificity ; Tandem Mass Spectrometry/methods ; Terfenadine/analysis ; Terfenadine/pharmacokinetics
Czasopismo naukowe
Tytuł :
Inhibitory effect of terfenadine on Kir2.1 and Kir2.3 channels.
Autorzy :
Delgado-Ramírez M; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, COL 28045, México.
Rodriguez-Leal FJ; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, COL 28045, México.
Rodríguez-Menchaca AA; Departamento de Fisiología y Biofísica, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, SLP 78210, México.
Moreno-Galindo EG; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, COL 28045, México.
Sanchez-Chapula JA; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, COL 28045, México.
Ferrer T; Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, COL 28045, México.
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Źródło :
Acta pharmaceutica (Zagreb, Croatia) [Acta Pharm] 2021 Jun 01; Vol. 71 (2), pp. 317-324.
Typ publikacji :
Journal Article
MeSH Terms :
Histamine H1 Antagonists, Non-Sedating/*pharmacology
Potassium Channels, Inwardly Rectifying/*drug effects
Terfenadine/*pharmacology
HEK293 Cells ; Histamine H1 Antagonists, Non-Sedating/administration & dosage ; Humans ; Inhibitory Concentration 50 ; Potassium Channels, Inwardly Rectifying/metabolism ; Terfenadine/administration & dosage
Czasopismo naukowe
Tytuł :
A Review of Different Analytical Techniques for Fexofenadine Hydrochloride and Montelukast Sodium in Different Matrices.
Autorzy :
Nalini CN; Pharmaceutical Analysis, C.L. Baid Metha College of Pharmacy, Chennai, India.
Kumar V; Pharmaceutical Analysis, C.L. Baid Metha College of Pharmacy, Chennai, India.
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Źródło :
Critical reviews in analytical chemistry [Crit Rev Anal Chem] 2021; Vol. 51 (3), pp. 232-245. Date of Electronic Publication: 2020 Jan 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Acetates/*analysis
Anti-Allergic Agents/*analysis
Chemistry Techniques, Analytical/*methods
Cyclopropanes/*analysis
Drug Monitoring/*methods
Leukotriene Antagonists/*analysis
Quinolines/*analysis
Sulfides/*analysis
Terfenadine/*analogs & derivatives
Acetates/pharmacokinetics ; Animals ; Anti-Allergic Agents/pharmacokinetics ; Anti-Asthmatic Agents/analysis ; Anti-Asthmatic Agents/pharmacokinetics ; Chemistry Techniques, Analytical/instrumentation ; Cyclopropanes/pharmacokinetics ; Drug Monitoring/instrumentation ; Histamine H1 Antagonists, Non-Sedating/analysis ; Histamine H1 Antagonists, Non-Sedating/pharmacokinetics ; Humans ; Leukotriene Antagonists/pharmacokinetics ; Quinolines/pharmacokinetics ; Sulfides/pharmacokinetics ; Terfenadine/analysis ; Terfenadine/pharmacokinetics
Czasopismo naukowe
Tytuł :
Effects of breviscapine and C3435T MDR1 gene polymorphism on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy volunteers.
Autorzy :
Zhao Y; College of Pharmacy, Dali University, Dali, Yunnan, China.
Miao Z; College of Pharmacy, Dali University, Dali, Yunnan, China.
Jiang M; College of Pharmacy, Dali University, Dali, Yunnan, China.
Zhou X; College of Pharmacy, Dali University, Dali, Yunnan, China.
Lai Y; College of Pharmacy, Dali University, Dali, Yunnan, China.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Mar; Vol. 51 (3), pp. 366-372. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Polymorphism, Genetic*
Flavonoids/*pharmacology
Terfenadine/*analogs & derivatives
ATP Binding Cassette Transporter, Subfamily B/genetics ; Area Under Curve ; Cross-Over Studies ; Healthy Volunteers ; Humans ; Tandem Mass Spectrometry ; Terfenadine/pharmacokinetics
Czasopismo naukowe
Tytuł :
The Role of P-Glycoprotein in Decreasing Cell Membranes Permeability during Oxidative Stress.
Autorzy :
Shchulkin AV; Ryazan State Medical University, Ryazan, 390026, Russia. .
Abalenikhina YV; Ryazan State Medical University, Ryazan, 390026, Russia.
Erokhina PD; Ryazan State Medical University, Ryazan, 390026, Russia.
Chernykh IV; Ryazan State Medical University, Ryazan, 390026, Russia.
Yakusheva EN; Ryazan State Medical University, Ryazan, 390026, Russia.
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Źródło :
Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2021 Feb; Vol. 86 (2), pp. 197-206.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Membrane Permeability*
Oxidative Stress*
NF-E2-Related Factor 2/*genetics
Terfenadine/*analogs & derivatives
ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; Caco-2 Cells ; Gene Expression Regulation, Neoplastic ; Humans ; Hydrogen Peroxide/toxicity ; Lipid Peroxidation ; Terfenadine/metabolism
Czasopismo naukowe
Tytuł :
Acute generalized exanthematous pustulosis induced by pseudoephedrine in a combination tablet with fexofenadine.
Autorzy :
Kusutani N; Department of Dermatology, Osaka City General Hospital, Osaka, Japan.
Nishida M; Department of Dermatology, Osaka City General Hospital, Osaka, Japan.
Sowa-Osako J; Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Maekawa N; Department of Dermatology, Osaka City General Hospital, Osaka, Japan.
Fukai K; Department of Dermatology, Osaka City General Hospital, Osaka, Japan.
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Źródło :
International journal of dermatology [Int J Dermatol] 2021 Jul; Vol. 60 (7), pp. e286-e288. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Letter
MeSH Terms :
Acute Generalized Exanthematous Pustulosis*/etiology
Humans ; Pseudoephedrine/adverse effects ; Tablets ; Terfenadine/adverse effects ; Terfenadine/analogs & derivatives
Opinia redakcyjna
Tytuł :
Efficacy of histamine H1 receptor antagonists azelastine and fexofenadine against cutaneous Leishmania major infection.
Autorzy :
Peniche AG; Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America.
Osorio EY; Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America.
Melby PC; Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America.; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America.
Travi BL; Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America.; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America.
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Źródło :
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Aug 10; Vol. 14 (8), pp. e0008482. Date of Electronic Publication: 2020 Aug 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Histamine H1 Antagonists, Non-Sedating/*therapeutic use
Leishmaniasis, Cutaneous/*drug therapy
Phthalazines/*therapeutic use
Terfenadine/*analogs & derivatives
Animals ; Leishmania major ; Lymph Nodes/parasitology ; Male ; Mice ; Mice, Inbred BALB C ; Molecular Structure ; Phthalazines/chemistry ; Terfenadine/chemistry ; Terfenadine/therapeutic use ; Tissue Culture Techniques
Czasopismo naukowe
Tytuł :
Association Between Fexofenadine Use During Pregnancy and Fetal Outcomes.
Autorzy :
Andersson NW; Department of Clinical Pharmacology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen NV, Denmark.
Torp-Pedersen C; Department of Cardiology and Clinical Research, Nordsjællands Hospital, Hillerød, Denmark.; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Andersen JT; Department of Clinical Pharmacology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen NV, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Źródło :
JAMA pediatrics [JAMA Pediatr] 2020 Aug 01; Vol. 174 (8), pp. e201316. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Infant, Small for Gestational Age*
Propensity Score*
Pregnancy Complications/*drug therapy
Premature Birth/*epidemiology
Prenatal Care/*methods
Terfenadine/*analogs & derivatives
Adult ; Female ; Follow-Up Studies ; Histamine H1 Antagonists, Non-Sedating/pharmacology ; Humans ; Infant, Newborn ; Pregnancy ; Pregnancy Outcome ; Retrospective Studies ; Terfenadine/pharmacology ; Young Adult
Czasopismo naukowe
Tytuł :
Urticaria and angioedema as a prodromal cutaneous manifestation of SARS-CoV-2 (COVID-19) infection.
Autorzy :
Hassan K; Loch Lomond Surgery, 75 Bank Street, Alexandria, Scotland .; Department of Dermatology, Vale of Leven Hospital, Alexandria, Scotland.
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Źródło :
BMJ case reports [BMJ Case Rep] 2020 Jul 07; Vol. 13 (7). Date of Electronic Publication: 2020 Jul 07.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Angioedema*/diagnosis
Angioedema*/etiology
Angioedema*/physiopathology
Coronavirus Infections*/complications
Coronavirus Infections*/diagnosis
Coronavirus Infections*/physiopathology
Pandemics*
Pneumonia, Viral*/complications
Pneumonia, Viral*/diagnosis
Pneumonia, Viral*/physiopathology
Urticaria*/diagnosis
Urticaria*/etiology
Urticaria*/physiopathology
Chlorpheniramine/*administration & dosage
Prednisone/*administration & dosage
Terfenadine/*analogs & derivatives
Anti-Allergic Agents/administration & dosage ; Betacoronavirus/isolation & purification ; COVID-19 ; Diagnosis, Differential ; Female ; Humans ; Middle Aged ; Prodromal Symptoms ; SARS-CoV-2 ; Terfenadine/administration & dosage ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Chiral Discrimination of P-glycoprotein in Parturient Women: Effect of Fluoxetine on Maternal-Fetal Fexofenadine Pharmacokinetics.
Autorzy :
Pinto L; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Moreira FL; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Nardotto GHB; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Cavalli RC; Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Moisés ECD; Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Duarte G; Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Lanchote VL; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. .
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Źródło :
Pharmaceutical research [Pharm Res] 2020 Jun 17; Vol. 37 (7), pp. 131. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji :
Journal Article
MeSH Terms :
Parturition*
Antidepressive Agents, Second-Generation/*administration & dosage
Fluoxetine/*administration & dosage
Histamine H1 Antagonists, Non-Sedating/*pharmacokinetics
Intestinal Absorption/*drug effects
Intestinal Mucosa/*drug effects
Terfenadine/*analogs & derivatives
ATP Binding Cassette Transporter, Subfamily B/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; Adult ; Antidepressive Agents, Second-Generation/adverse effects ; Case-Control Studies ; Drug Interactions ; Female ; Fetal Blood/metabolism ; Fluoxetine/adverse effects ; Histamine H1 Antagonists, Non-Sedating/administration & dosage ; Histamine H1 Antagonists, Non-Sedating/blood ; Humans ; Intestinal Mucosa/metabolism ; Maternal-Fetal Exchange ; Placental Circulation ; Pregnancy ; Terfenadine/administration & dosage ; Terfenadine/blood ; Terfenadine/pharmacokinetics ; Young Adult
Czasopismo naukowe
Tytuł :
Direct chiral LC-MS/MS analysis of fexofenadine enantiomers in plasma and urine with application in a maternal-fetal pharmacokinetic study.
Autorzy :
Pinto LSR; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Vale GTD; Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Moreira FL; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Marques MP; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Coelho EB; Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Cavalli RC; Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Lanchote VL; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. Electronic address: .
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Źródło :
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2020 May 15; Vol. 1145, pp. 122094. Date of Electronic Publication: 2020 Apr 06.
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
Anti-Allergic Agents/*blood
Anti-Allergic Agents/*urine
Chromatography, High Pressure Liquid/*methods
Tandem Mass Spectrometry/*methods
Terfenadine/*analogs & derivatives
Adult ; Anti-Allergic Agents/chemistry ; Anti-Allergic Agents/pharmacokinetics ; Female ; Humans ; Plasma/chemistry ; Pregnancy ; Stereoisomerism ; Terfenadine/blood ; Terfenadine/chemistry ; Terfenadine/pharmacokinetics ; Terfenadine/urine ; Urine/chemistry ; Young Adult
Czasopismo naukowe
Tytuł :
Utilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes.
Autorzy :
Goto A; Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.
Sakamoto K; Ina Research Inc., 2148-188 Nishiminowa, Ina-shi, Nagano, 399-4501, Japan.
Hagiwara-Nagasawa M; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.
Kambayashi R; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.
Chiba K; Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.
Nunoi Y; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.
Izumi-Nakaseko H; Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.
Matsumoto A; Department of Aging Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.
Sugiyama A; Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan; Department of Aging Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan. Electronic address: .
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Źródło :
Journal of pharmacological sciences [J Pharmacol Sci] 2020 Apr; Vol. 142 (4), pp. 172-175. Date of Electronic Publication: 2020 Jan 07.
Typ publikacji :
Journal Article
MeSH Terms :
Atrioventricular Block*
Disease Models, Animal*
Drug Synergism*
Ketoconazole/*adverse effects
Terfenadine/*adverse effects
Torsades de Pointes/*chemically induced
Animals ; Chronic Disease ; Ketoconazole/administration & dosage ; Macaca fascicularis ; Polypharmacy ; Terfenadine/administration & dosage
Czasopismo naukowe
Tytuł :
Evaluation of potential herbal-drug interactions of a standardized propolis extract (EPP-AF®) using an in vivo cocktail approach.
Autorzy :
Cusinato DAC; School of Pharmaceutical Sciences of Ribeirão Preto, Department of Clinical Analysis, Toxicology and Food Science, University of São Paulo, Brazil.
Martinez EZ; Ribeirão Preto Medical School, Department of Social Medicine, University of São Paulo Ribeirão Preto, Brazil.
Cintra MTC; General Clinical Research Center, Teaching Hospital Ribeirão Preto, Brazil.
Filgueira GCO; Medical School, University of São Paulo Medical School, Department of Obstetrics and Gynecology, University of São Paulo, Brazil.
Berretta AA; Laboratório de Pesquisa, Desenvolvimento & Inovação, Apis Flora Indl. Coml. Ltda., Ribeirão Preto, SP, Brazil.
Lanchote VL; School of Pharmaceutical Sciences of Ribeirão Preto, Department of Clinical Analysis, Toxicology and Food Science, University of São Paulo, Brazil.
Coelho EB; School of Pharmaceutical Sciences of Ribeirão Preto, Department of Clinical Analysis, Toxicology and Food Science, University of São Paulo, Brazil; Ribeirão Preto Medical School, Department of Internal Medicine, University of São Paulo, Brazil. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2019 Dec 05; Vol. 245, pp. 112174. Date of Electronic Publication: 2019 Aug 20.
Typ publikacji :
Clinical Trial, Phase II; Journal Article
MeSH Terms :
Propolis*
Caffeine/*pharmacokinetics
Losartan/*pharmacokinetics
Metoprolol/*pharmacokinetics
Midazolam/*pharmacokinetics
Omeprazole/*pharmacokinetics
Terfenadine/*analogs & derivatives
ATP Binding Cassette Transporter, Subfamily B/metabolism ; Adult ; Caffeine/blood ; Cross-Over Studies ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Drug Interactions ; Female ; Humans ; Losartan/blood ; Male ; Metoprolol/blood ; Midazolam/blood ; Omeprazole/blood ; Terfenadine/blood ; Terfenadine/pharmacokinetics
Czasopismo naukowe
Tytuł :
Antihistamine effects and safety of fexofenadine: a systematic review and Meta-analysis of randomized controlled trials.
Autorzy :
Huang CZ; Department of Otolaryngology Head and Neck Surgery, General Hospital of Southern Theatre Command of PLA, Guangzhou, 510010, China.; Department of Otolaryngology Head and Neck Surgery, Shenzhen University General Hospital, Shenzhen, 518055, China.
Jiang ZH; Department of Pharmacy, General Hospital of Southern Theatre Command of PLA, Guangzhou, 510010, China.
Wang J; Department of Otolaryngology Head and Neck Surgery, General Hospital of Southern Theatre Command of PLA, Guangzhou, 510010, China.
Luo Y; Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510315, China.; Cancer Center, Southern Medical University, Guangzhou, 510315, China.
Peng H; Department of Otolaryngology Head and Neck Surgery, General Hospital of Southern Theatre Command of PLA, Guangzhou, 510010, China. .
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Źródło :
BMC pharmacology & toxicology [BMC Pharmacol Toxicol] 2019 Nov 29; Vol. 20 (1), pp. 72. Date of Electronic Publication: 2019 Nov 29.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms :
Drug-Related Side Effects and Adverse Reactions*/epidemiology
Drug-Related Side Effects and Adverse Reactions*/etiology
Histamine H1 Antagonists, Non-Sedating/*pharmacology
Terfenadine/*analogs & derivatives
Cognition/drug effects ; Histamine H1 Antagonists, Non-Sedating/adverse effects ; Humans ; Psychomotor Performance/drug effects ; Randomized Controlled Trials as Topic ; Terfenadine/adverse effects ; Terfenadine/pharmacology
Czasopismo naukowe
Tytuł :
Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine.
Autorzy :
Xie QS; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Zhang JX; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Liu M; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Liu PH; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Wang ZJ; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Zhu L; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Jiang L; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Jin MM; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Liu XN; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Liu L; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. .
Liu XD; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. .
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Źródło :
Acta pharmacologica Sinica [Acta Pharmacol Sin] 2021 Mar; Vol. 42 (3), pp. 470-481. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily B, Member 1/*metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Acetates/*pharmacology
Butyrates/*pharmacology
Intestinal Mucosa/*metabolism
Propionates/*pharmacology
Animals ; Caco-2 Cells ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Male ; Mice, Inbred BALB C ; NF-kappa B/metabolism ; PPAR gamma/metabolism ; Rats, Sprague-Dawley ; Rosuvastatin Calcium/pharmacokinetics ; Signal Transduction/drug effects ; Terfenadine/analogs & derivatives ; Terfenadine/pharmacokinetics
Czasopismo naukowe
Tytuł :
Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis.
Autorzy :
Liu R; Department of Orthopaedic Surgery, New York University Medical Center, New York City, New York, USA.
Chen Y; Department of Orthopaedic Surgery, New York University Medical Center, New York City, New York, USA.
Fu W; Department of Orthopaedic Surgery, New York University Medical Center, New York City, New York, USA.
Wang S; Department of Orthopaedic Surgery, New York University Medical Center, New York City, New York, USA.
Cui Y; Department of Orthopaedic Surgery, New York University Medical Center, New York City, New York, USA.
Zhao X; Department of Orthopaedic Surgery, New York University Medical Center, New York City, New York, USA.
Lei ZN; Department of Pharmaceutical Science, College ofPharmacy and Health Sciences, St. John's University, New York, NY, USA.
Hettinghouse A; Department of Orthopaedic Surgery, New York University Medical Center, New York City, New York, USA.
Liu J; Department of Orthopaedic Surgery, New York University Medical Center, New York City, New York, USA.
Wang C; Department of Orthopaedic Surgery, New York University Medical Center, New York City, New York, USA.
Zhang C; Department of Orthopaedic Surgery, New York University Medical Center, New York City, New York, USA.
Bi Y; Department of Orthopaedic Surgery, New York University Medical Center, New York City, New York, USA.
Xiao G; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA.
Chen ZS; Department of Pharmaceutical Science, College ofPharmacy and Health Sciences, St. John's University, New York, NY, USA.
Liu CJ; Department of Orthopaedic Surgery, New York University Medical Center, New York City, New York, USA .; Departmentof Cell Biology, New York University School of Medicine, New York, NY, USA.
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Źródło :
Annals of the rheumatic diseases [Ann Rheum Dis] 2019 Nov; Vol. 78 (11), pp. 1524-1535. Date of Electronic Publication: 2019 Jul 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Arthritis, Experimental/*drug therapy
Phospholipases A2, Cytosolic/*drug effects
Terfenadine/*analogs & derivatives
Tumor Necrosis Factor Inhibitors/*pharmacology
Animals ; Mice ; Mice, Inbred DBA ; Mice, Transgenic ; Signal Transduction/drug effects ; Terfenadine/pharmacology ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Modulation of Fexofenadine Pharmacokinetics by Osimertinib in Patients With Advanced EGFR-Mutated Non-Small Cell Lung Cancer.
Autorzy :
Calvo E; START Madrid - CIOCC, Centro Integral Oncológico Clara Campal, Hospital Madrid Norte Sanchinarro, Madrid, Spain.
Lee JS; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Kim SW; Department of Oncology, Asan Medical Center, Seoul, South Korea.
Moreno V; START MADRID - FJD, Hospital Fundación Jiménez Díaz, Madrid, Spain.
deCastro Carpeno J; Hospital Universitario La Paz, Madrid, Spain.
Weilert D; IQVIA, Overland Park, KS, USA.
Laus G; QCP, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Waltham, MA, USA.
Mann H; QCP, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Waltham, MA, USA.
Vishwanathan K; QCP, Early Clinical Development, IMED Biotech Unit, AstraZeneca, Waltham, MA, USA.
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Źródło :
Journal of clinical pharmacology [J Clin Pharmacol] 2019 Aug; Vol. 59 (8), pp. 1099-1109. Date of Electronic Publication: 2019 Mar 15.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Acrylamides/*pharmacology
Aniline Compounds/*pharmacology
Anti-Allergic Agents/*pharmacokinetics
Antineoplastic Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Terfenadine/*analogs & derivatives
ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors ; Aged ; Anti-Allergic Agents/blood ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/embryology ; Carcinoma, Non-Small-Cell Lung/genetics ; Drug Interactions ; ErbB Receptors/genetics ; Female ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Male ; Middle Aged ; Mutation ; Terfenadine/blood ; Terfenadine/pharmacokinetics
Czasopismo naukowe
Tytuł :
Fexofenadine and Rosuvastatin Pharmacokinetics in Mice with Targeted Disruption of Organic Anion Transporting Polypeptide 2B1.
Autorzy :
Medwid S; Department of Physiology and Pharmacology (S.M., M.M.J.L., M.J.K., K.L., C.Z., K.E.G., M.D.Y., U.I.S., R.B.K., R.G.T.), and Division of Clinical Pharmacology, Department of Medicine (S.E.M., C.L.S., G.K.D., U.I.S., R.B.K., R.G.T.), University of Western Ontario, London, Ontario, Canada.
Li MMJ; Department of Physiology and Pharmacology (S.M., M.M.J.L., M.J.K., K.L., C.Z., K.E.G., M.D.Y., U.I.S., R.B.K., R.G.T.), and Division of Clinical Pharmacology, Department of Medicine (S.E.M., C.L.S., G.K.D., U.I.S., R.B.K., R.G.T.), University of Western Ontario, London, Ontario, Canada.
Knauer MJ; Department of Physiology and Pharmacology (S.M., M.M.J.L., M.J.K., K.L., C.Z., K.E.G., M.D.Y., U.I.S., R.B.K., R.G.T.), and Division of Clinical Pharmacology, Department of Medicine (S.E.M., C.L.S., G.K.D., U.I.S., R.B.K., R.G.T.), University of Western Ontario, London, Ontario, Canada.
Lin K; Department of Physiology and Pharmacology (S.M., M.M.J.L., M.J.K., K.L., C.Z., K.E.G., M.D.Y., U.I.S., R.B.K., R.G.T.), and Division of Clinical Pharmacology, Department of Medicine (S.E.M., C.L.S., G.K.D., U.I.S., R.B.K., R.G.T.), University of Western Ontario, London, Ontario, Canada.
Mansell SE; Department of Physiology and Pharmacology (S.M., M.M.J.L., M.J.K., K.L., C.Z., K.E.G., M.D.Y., U.I.S., R.B.K., R.G.T.), and Division of Clinical Pharmacology, Department of Medicine (S.E.M., C.L.S., G.K.D., U.I.S., R.B.K., R.G.T.), University of Western Ontario, London, Ontario, Canada.
Schmerk CL; Department of Physiology and Pharmacology (S.M., M.M.J.L., M.J.K., K.L., C.Z., K.E.G., M.D.Y., U.I.S., R.B.K., R.G.T.), and Division of Clinical Pharmacology, Department of Medicine (S.E.M., C.L.S., G.K.D., U.I.S., R.B.K., R.G.T.), University of Western Ontario, London, Ontario, Canada.
Zhu C; Department of Physiology and Pharmacology (S.M., M.M.J.L., M.J.K., K.L., C.Z., K.E.G., M.D.Y., U.I.S., R.B.K., R.G.T.), and Division of Clinical Pharmacology, Department of Medicine (S.E.M., C.L.S., G.K.D., U.I.S., R.B.K., R.G.T.), University of Western Ontario, London, Ontario, Canada.
Griffin KE; Department of Physiology and Pharmacology (S.M., M.M.J.L., M.J.K., K.L., C.Z., K.E.G., M.D.Y., U.I.S., R.B.K., R.G.T.), and Division of Clinical Pharmacology, Department of Medicine (S.E.M., C.L.S., G.K.D., U.I.S., R.B.K., R.G.T.), University of Western Ontario, London, Ontario, Canada.
Yousif MD; Department of Physiology and Pharmacology (S.M., M.M.J.L., M.J.K., K.L., C.Z., K.E.G., M.D.Y., U.I.S., R.B.K., R.G.T.), and Division of Clinical Pharmacology, Department of Medicine (S.E.M., C.L.S., G.K.D., U.I.S., R.B.K., R.G.T.), University of Western Ontario, London, Ontario, Canada.
Dresser GK; Department of Physiology and Pharmacology (S.M., M.M.J.L., M.J.K., K.L., C.Z., K.E.G., M.D.Y., U.I.S., R.B.K., R.G.T.), and Division of Clinical Pharmacology, Department of Medicine (S.E.M., C.L.S., G.K.D., U.I.S., R.B.K., R.G.T.), University of Western Ontario, London, Ontario, Canada.
Schwarz UI; Department of Physiology and Pharmacology (S.M., M.M.J.L., M.J.K., K.L., C.Z., K.E.G., M.D.Y., U.I.S., R.B.K., R.G.T.), and Division of Clinical Pharmacology, Department of Medicine (S.E.M., C.L.S., G.K.D., U.I.S., R.B.K., R.G.T.), University of Western Ontario, London, Ontario, Canada.
Kim RB; Department of Physiology and Pharmacology (S.M., M.M.J.L., M.J.K., K.L., C.Z., K.E.G., M.D.Y., U.I.S., R.B.K., R.G.T.), and Division of Clinical Pharmacology, Department of Medicine (S.E.M., C.L.S., G.K.D., U.I.S., R.B.K., R.G.T.), University of Western Ontario, London, Ontario, Canada.
Tirona RG; Department of Physiology and Pharmacology (S.M., M.M.J.L., M.J.K., K.L., C.Z., K.E.G., M.D.Y., U.I.S., R.B.K., R.G.T.), and Division of Clinical Pharmacology, Department of Medicine (S.E.M., C.L.S., G.K.D., U.I.S., R.B.K., R.G.T.), University of Western Ontario, London, Ontario, Canada .
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Źródło :
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2019 Aug; Vol. 47 (8), pp. 832-842. Date of Electronic Publication: 2019 May 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Intestinal Mucosa/*metabolism
Organic Anion Transporters/*metabolism
Rosuvastatin Calcium/*pharmacokinetics
Terfenadine/*analogs & derivatives
Administration, Intravenous ; Administration, Oral ; Animals ; Area Under Curve ; Food-Drug Interactions ; Fruit and Vegetable Juices ; HEK293 Cells ; HeLa Cells ; Humans ; Intestinal Absorption ; Male ; Mice ; Mice, Knockout ; Organic Anion Transporters/genetics ; Rosuvastatin Calcium/administration & dosage ; Terfenadine/administration & dosage ; Terfenadine/pharmacokinetics
Czasopismo naukowe
Tytuł :
Evaluation of UV-C Decontamination of Clinical Tissue Sections for Spatially Resolved Analysis by Mass Spectrometry Imaging (MSI).
Autorzy :
Dannhorn A; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, 605 SAF Building, South Kensington Campus, London CB4 0FZ, U.K.; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge SW7 2AZ, U.K.
Ling S; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge SW7 2AZ, U.K.
Powell S; Safety, Health and Environment (SHE), Cambridge Operations, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB4 0FZ, U.K.
McCall E; Safety, Health and Environment (SHE), Cambridge Operations, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB4 0FZ, U.K.
Maglennon G; Oncology Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB22 3AT, U.K.
Jones GN; Translational Medicine, Oncology R&D, AstraZeneca, Cambridge SG8 6EH, U.K.
Pierce AJ; Translational Medicine, Oncology R&D, AstraZeneca, Cambridge SG8 6EH, U.K.
Strittmatter N; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge SW7 2AZ, U.K.
Hamm G; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge SW7 2AZ, U.K.
Barry ST; Bioscience, Discovery, Oncology R&D, AstraZeneca, Cambridge CB2 0RE, U.K.
Bunch J; National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), National Physical Laboratory, Teddington TW11 0LW, U.K.
Goodwin RJA; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge SW7 2AZ, U.K.; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K.
Takats Z; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, 605 SAF Building, South Kensington Campus, London CB4 0FZ, U.K.
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Źródło :
Analytical chemistry [Anal Chem] 2021 Feb 09; Vol. 93 (5), pp. 2767-2775. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ultraviolet Rays*
Decontamination/*methods
Animals ; Azetidines/analysis ; Azetidines/therapeutic use ; COVID-19/pathology ; COVID-19/virology ; Head and Neck Neoplasms/chemistry ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/pathology ; Humans ; Male ; Metabolome ; Naphthalenes/analysis ; Naphthalenes/therapeutic use ; Photolysis/radiation effects ; Rats ; Rats, Wistar ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/radiation effects ; Spectrometry, Mass, Electrospray Ionization/methods ; Terfenadine/chemistry ; Virus Inactivation/radiation effects
Czasopismo naukowe
Tytuł :
Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS).
Autorzy :
Sakolish C; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA.
Reese CE; Drug Discovery Institute and Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Luo YS; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA.
Valdiviezo A; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA.
Schurdak ME; Drug Discovery Institute and Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Gough A; Drug Discovery Institute and Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Taylor DL; Drug Discovery Institute and Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Chiu WA; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA.
Vernetti LA; Drug Discovery Institute and Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Rusyn I; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA. Electronic address: .
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Źródło :
Toxicology [Toxicology] 2021 Jan 30; Vol. 448, pp. 152651. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Acinar Cells/*drug effects
Acinar Cells/*metabolism
Cell Culture Techniques/*methods
Hepatocytes/*drug effects
Hepatocytes/*metabolism
Microfluidics/*methods
Acinar Cells/pathology ; Hepatocytes/pathology ; Histamine H1 Antagonists, Non-Sedating/toxicity ; Humans ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Terfenadine/toxicity
Czasopismo naukowe

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