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Tytuł :
High Intakes of [6S]-5-Methyltetrahydrofolic Acid Compared with Folic Acid during Pregnancy Programs Central and Peripheral Mechanisms Favouring Increased Food Intake and Body Weight of Mature Female Offspring.
Autorzy :
Pannia E; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Hammoud R; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Kubant R; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Sa JY; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Simonian R; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Wasek B; Center of Metabolomics, Institute of Metabolic Disease, Baylor Scott and White Health, Dallas, TX 75226, USA.
Ashcraft P; Center of Metabolomics, Institute of Metabolic Disease, Baylor Scott and White Health, Dallas, TX 75226, USA.
Bottiglieri T; Center of Metabolomics, Institute of Metabolic Disease, Baylor Scott and White Health, Dallas, TX 75226, USA.
Pausova Z; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Anderson GH; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
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Źródło :
Nutrients [Nutrients] 2021 Apr 27; Vol. 13 (5). Date of Electronic Publication: 2021 Apr 27.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Body Weight/*drug effects
Diet/*methods
Energy Intake/*drug effects
Feeding Behavior/*drug effects
Folic Acid/*pharmacology
Tetrahydrofolates/*pharmacology
Animals ; Animals, Newborn ; Energy Metabolism/drug effects ; Female ; Folic Acid/administration & dosage ; Mice ; Models, Animal ; Pregnancy ; Rats, Wistar ; Tetrahydrofolates/administration & dosage ; Vitamin B Complex/administration & dosage ; Vitamin B Complex/pharmacology
Czasopismo naukowe
Tytuł :
Pharmacokinetics of Sodium and Calcium Salts of (6S)-5-Methyltetrahydrofolic Acid Compared to Folic Acid and Indirect Comparison of the Two Salts.
Autorzy :
Obeid R; Laboratory Medicine, Department of Clinical Chemistry, Saarland University Hospital, Building 57, D-66424 Homburg/Saar, Germany.
Schön C; BioTeSys GmbH, Schelztorstr. 54-56, D-73728 Esslingen, Germany.
Pietrzik K; Department of Nutrition and Food Science, Rheinische Friedrich-Wilhelms University, Endenicher Allee 19B, D-53115 Bonn, Germany.
Menzel D; BioTeSys GmbH, Schelztorstr. 54-56, D-73728 Esslingen, Germany.
Wilhelm M; Department of Mathematics, Natural and Economic Sciences, Ulm University of Applied Sciences, Albert-Einstein-Allee 55, D-89081 Ulm, Germany.
Smulders Y; Department of Internal Medicine, Amsterdam UMC, Location VUmc, 1081 HV Amsterdam, The Netherlands.
Knapp JP; Merck & Cie, Im Laternenacker 5, CH-8200 Schaffhausen, Switzerland.
Böhni R; Merck & Cie, Im Laternenacker 5, CH-8200 Schaffhausen, Switzerland.
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Źródło :
Nutrients [Nutrients] 2020 Nov 25; Vol. 12 (12). Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Folic Acid/*pharmacokinetics
Tetrahydrofolates/*pharmacokinetics
Adult ; Area Under Curve ; Cross-Over Studies ; Double-Blind Method ; Female ; Folic Acid/blood ; Humans ; Male ; Tetrahydrofolates/blood ; Tetrahydrofolates/chemistry ; Young Adult
Czasopismo naukowe
Tytuł :
L-methylfolate, a new option in psychiatric treatment, would it be linked to psoriasis relapse?
Autorzy :
Pitliuk R; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Fucci TPPDCS; Nutricionista, São Paulo, SP, Brazil.
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Źródło :
Einstein (Sao Paulo, Brazil) [Einstein (Sao Paulo)] 2020 Nov 27; Vol. 18, pp. eRC5522. Date of Electronic Publication: 2020 Nov 27 (Print Publication: 2020).
Typ publikacji :
Case Reports
MeSH Terms :
Quality of Life*
Depression/*drug therapy
Homocystinuria/*complications
Methylenetetrahydrofolate Reductase (NADPH2)/*deficiency
Muscle Spasticity/*complications
Psoriasis/*chemically induced
Tetrahydrofolates/*administration & dosage
Female ; Humans ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Middle Aged ; Polymorphism, Genetic ; Psychotic Disorders/complications ; Recurrence ; Tetrahydrofolates/therapeutic use ; Treatment Outcome
SCR Disease Name :
Methylenetetrahydrofolate reductase deficiency
Raport
Tytuł :
Is natural (6S)-5-methyltetrahydrofolic acid as effective as synthetic folic acid in increasing serum and red blood cell folate concentrations during pregnancy? A proof-of-concept pilot study.
Autorzy :
Cochrane KM; Food, Nutrition and Health, Faculty of Land and Food Systems, The University of British Columbia, 2205 East Mall, Vancouver, BC, V6T 1Z4, Canada.; BC Children's Hospital Research Institute, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.
Mayer C; Department of Obstetrics and Gynaecology, University of British Columbia, 4500 Oak Street, Vancouver, BC, V6H 3N1, Canada.
Devlin AM; BC Children's Hospital Research Institute, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.; Department of Paediatrics, Faculty of Medicine, The University of British Columbia, 4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.
Elango R; BC Children's Hospital Research Institute, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.; Department of Paediatrics, Faculty of Medicine, The University of British Columbia, 4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.; School of Population and Public Health, Faculty of Medicine, The University of British Columbia, 2206 East Mall, Vancouver, BC, V6T 1Z3, Canada.
Hutcheon JA; BC Children's Hospital Research Institute, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.; Department of Obstetrics and Gynaecology, University of British Columbia, 4500 Oak Street, Vancouver, BC, V6H 3N1, Canada.
Karakochuk CD; Food, Nutrition and Health, Faculty of Land and Food Systems, The University of British Columbia, 2205 East Mall, Vancouver, BC, V6T 1Z4, Canada. .; BC Children's Hospital Research Institute, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada. .
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Źródło :
Trials [Trials] 2020 May 05; Vol. 21 (1), pp. 380. Date of Electronic Publication: 2020 May 05.
Typ publikacji :
Clinical Trial Protocol; Journal Article
MeSH Terms :
Dietary Supplements*
Neural Tube Defects/*prevention & control
Nutrition Therapy/*methods
Tetrahydrofolates/*administration & dosage
Tetrahydrofolates/*blood
Adult ; Biomarkers/blood ; Canada/epidemiology ; Double-Blind Method ; Female ; Humans ; Milk, Human/chemistry ; Neural Tube Defects/epidemiology ; Pilot Projects ; Pregnancy ; Randomized Controlled Trials as Topic ; Tetrahydrofolates/adverse effects ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Regulation of the one carbon folate cycle as a shared metabolic signature of longevity.
Autorzy :
Annibal A; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Tharyan RG; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Schonewolff MF; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Tam H; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Latza C; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Auler MMK; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Antebi A; Max Planck Institute for Biology of Ageing, Cologne, Germany. .; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 09; Vol. 12 (1), pp. 3486. Date of Electronic Publication: 2021 Jun 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Metabolic Networks and Pathways*/genetics
Carbon/*metabolism
Folic Acid/*metabolism
Longevity/*physiology
Animals ; Caenorhabditis elegans ; Insulin/metabolism ; Longevity/genetics ; Metabolome ; Methionine/metabolism ; Mice ; Mitochondria/genetics ; Mitochondria/metabolism ; Mutation ; Peptides/metabolism ; Signal Transduction ; Tetrahydrofolate Dehydrogenase/genetics ; Tetrahydrofolate Dehydrogenase/metabolism ; Tetrahydrofolates/metabolism ; Thymidylate Synthase/genetics ; Thymidylate Synthase/metabolism
Czasopismo naukowe
Tytuł :
A novel electrochemical paper sensor for low-cost detection of 5-methyltetrahydrofolate in egg yolk.
Autorzy :
Yu Y; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Scientific Observing and Experiment Station of Animal Genetic Resources and Nutrition in North China of Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Sun D; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Scientific Observing and Experiment Station of Animal Genetic Resources and Nutrition in North China of Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Liu Y; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Scientific Observing and Experiment Station of Animal Genetic Resources and Nutrition in North China of Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Zhao Q; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Scientific Observing and Experiment Station of Animal Genetic Resources and Nutrition in North China of Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Qin Y; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Scientific Observing and Experiment Station of Animal Genetic Resources and Nutrition in North China of Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Zhang J; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Scientific Observing and Experiment Station of Animal Genetic Resources and Nutrition in North China of Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Jun 01; Vol. 346, pp. 128901. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji :
Journal Article
MeSH Terms :
Paper*
Egg Yolk/*chemistry
Electrochemical Techniques/*methods
Tetrahydrofolates/*analysis
Carbon/chemistry ; Egg Yolk/metabolism ; Electrochemical Techniques/instrumentation ; Electrodes ; Gold/chemistry ; Limit of Detection ; Nanostructures/chemistry ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Modelling folates reaction kinetics during cowpea seed germination in comparison with soaking.
Autorzy :
Coffigniez F; UMR Qualisud, CIRAD, Univ Montpellier, TA B-95/16, 73 rue J-F. Breton, F- 34398 Montpelliercedex 5, France.
Rychlik M; Technical University of Munich, Alte Akademie 10, 85354 Freising, Germany; Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Coopers Plains, QLD 4108, Australia.
Mestres C; UMR Qualisud, CIRAD, Univ Montpellier, TA B-95/16, 73 rue J-F. Breton, F- 34398 Montpelliercedex 5, France.
Striegel L; Technical University of Munich, Alte Akademie 10, 85354 Freising, Germany.
Bohuon P; UMR QualiSud Food Process Engineering Research Unit, Montpellier SupAgro, Univ Montpellier,1101 av. Agropolis, B.P. 5098, F-34093 Montpellier cedex 5, France.
Briffaz A; UMR Qualisud, CIRAD, Univ Montpellier, TA B-95/16, 73 rue J-F. Breton, F- 34398 Montpelliercedex 5, France. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Mar 15; Vol. 340, pp. 127960. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article
MeSH Terms :
Germination*
Folic Acid/*metabolism
Seeds/*growth & development
Vigna/*growth & development
Folic Acid/analogs & derivatives ; Folic Acid/analysis ; Kinetics ; Models, Biological ; Seeds/metabolism ; Temperature ; Tetrahydrofolates/analysis ; Tetrahydrofolates/metabolism ; Vigna/metabolism
Czasopismo naukowe
Tytuł :
Four families of folate-independent methionine synthases.
Autorzy :
Price MN; Environmental Genomics and Systems Biology, Lawrence Berkeley National Lab, Berkeley, California, United States of America.
Deutschbauer AM; Environmental Genomics and Systems Biology, Lawrence Berkeley National Lab, Berkeley, California, United States of America.
Arkin AP; Environmental Genomics and Systems Biology, Lawrence Berkeley National Lab, Berkeley, California, United States of America.; Department of Bioengineering, University of California, Berkeley, California, United States of America.
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Źródło :
PLoS genetics [PLoS Genet] 2021 Feb 03; Vol. 17 (2), pp. e1009342. Date of Electronic Publication: 2021 Feb 03 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Multigene Family*
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/*genetics
Archaeal Proteins/*genetics
Bacterial Proteins/*genetics
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/metabolism ; Archaeal Proteins/metabolism ; Bacterial Proteins/metabolism ; Biosynthetic Pathways/genetics ; Folic Acid/chemistry ; Folic Acid/metabolism ; Homocysteine/chemistry ; Homocysteine/metabolism ; Iron-Sulfur Proteins/metabolism ; Methionine/chemistry ; Methionine/metabolism ; Models, Chemical ; Molecular Structure ; Oxygen/metabolism ; Tetrahydrofolates/chemistry ; Tetrahydrofolates/metabolism ; Vitamin B 12/analogs & derivatives ; Vitamin B 12/chemistry ; Vitamin B 12/metabolism
Czasopismo naukowe
Tytuł :
A pilot study to assess the effect of a three-month vitamin supplementation containing L-methylfolate on systemic homocysteine plasma concentrations and retinal blood flow in patients with diabetes.
Autorzy :
Schmidl D; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Howorka K; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Szegedi S; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Stjepanek K; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.; Department of Ophthalmology, Vienna Institute for Research in Ocular Surgery - Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria.
Puchner S; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Bata A; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Scheschy U; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Aschinger G; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Werkmeister RM; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Schmetterer L; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.; Singapore Eye Research Institute, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.; SERI-NTU Advanced Ocular Engineering (STANCE), Singapore, Singapore.; Institute of Ophthalmology, Basel, Switzerland.
Garhofer G; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
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Źródło :
Molecular vision [Mol Vis] 2020 Apr 24; Vol. 26, pp. 326-333. Date of Electronic Publication: 2020 Apr 24 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood Circulation/*drug effects
Diabetes Mellitus/*blood
Homocysteine/*blood
Retina/*drug effects
Retinal Vessels/*drug effects
Tetrahydrofolates/*administration & dosage
Vitamins/*administration & dosage
Adolescent ; Adult ; Aged ; Diabetes Mellitus/diet therapy ; Dietary Supplements ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Retina/metabolism ; Retinal Vessels/physiology ; Tetrahydrofolates/blood ; Tomography, Optical Coherence ; Vitamin B 12/administration & dosage ; Vitamin B 12/analogs & derivatives
Czasopismo naukowe
Tytuł :
Structures in Tetrahydrofolate Methylation in Desulfitobacterial Glycine Betaine Metabolism at Atomic Resolution.
Autorzy :
Badmann T; Center for Integrated Protein Science Munich (CIPSM), Department of Chemistry, Technische Universität München, Lichtenbergstrasse 4, 85748, Garching, Germany.
Groll M; Center for Integrated Protein Science Munich (CIPSM), Department of Chemistry, Technische Universität München, Lichtenbergstrasse 4, 85748, Garching, Germany.
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Źródło :
Chembiochem : a European journal of chemical biology [Chembiochem] 2020 Mar 16; Vol. 21 (6), pp. 776-779. Date of Electronic Publication: 2019 Nov 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Betaine/*metabolism
Desulfitobacterium/*chemistry
Tetrahydrofolates/*metabolism
Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Betaine/chemistry ; Biocatalysis ; Crystallography, X-Ray ; Desulfitobacterium/metabolism ; Methylation ; Models, Molecular ; Molecular Structure ; Tetrahydrofolates/chemistry
SCR Organism :
Desulfitobacterium hafniense
Czasopismo naukowe
Tytuł :
Preclinical evaluation of 5-methyltetrahydrofolate-based radioconjugates-new perspectives for folate receptor-targeted radionuclide therapy.
Autorzy :
Guzik P; Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute - PSI, 5232, Villigen-PSI, Switzerland.
Benešová M; Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute - PSI, 5232, Villigen-PSI, Switzerland.; Department of Chemistry and Applied Biosciences, ETH Zurich, 8093, Zurich, Switzerland.
Ratz M; Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute - PSI, 5232, Villigen-PSI, Switzerland.
Monné Rodríguez JM; Laboratory for Animal Model Pathology (LAMP), Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, 8057, Zurich, Switzerland.
Deberle LM; Department of Chemistry and Applied Biosciences, ETH Zurich, 8093, Zurich, Switzerland.
Schibli R; Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute - PSI, 5232, Villigen-PSI, Switzerland.; Department of Chemistry and Applied Biosciences, ETH Zurich, 8093, Zurich, Switzerland.
Müller C; Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute - PSI, 5232, Villigen-PSI, Switzerland. .; Department of Chemistry and Applied Biosciences, ETH Zurich, 8093, Zurich, Switzerland. .
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Źródło :
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2021 Apr; Vol. 48 (4), pp. 972-983. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Folic Acid*
Radiopharmaceuticals*/therapeutic use
Animals ; Cell Line, Tumor ; Lutetium/therapeutic use ; Mice ; Radioisotopes/therapeutic use ; Tetrahydrofolates ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Folate Content and Yolk Color of Hen Eggs from Different Farming Systems.
Autorzy :
Czarnowska-Kujawska M; Department of Commodity and Food Analysis, The Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.
Draszanowska A; Department of Human Nutrition, The Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.
Gujska E; Department of Commodity and Food Analysis, The Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.
Klepacka J; Department of Commodity and Food Analysis, The Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.
Kasińska M; Department of Commodity and Food Analysis, The Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 16; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article
MeSH Terms :
Agriculture*
Egg Yolk/*chemistry
Eggs/*analysis
Folic Acid/*analysis
Adolescent ; Adult ; Animals ; Chickens ; Child ; Child, Preschool ; Color ; Cooking ; Female ; Folic Acid/chemistry ; Humans ; Infant ; Male ; Polyglutamic Acid/analogs & derivatives ; Polyglutamic Acid/chemistry ; Tetrahydrofolates/chemistry ; Young Adult
Czasopismo naukowe
Tytuł :
Modified EMR-lipid method combined with HPLC-MS/MS to determine folates in egg yolks from laying hens supplemented with different amounts of folic acid.
Autorzy :
Sun D; State Key Laboratory of Animal Nutrition, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing 100193, China; Scientific Observing and Experiment Station of Animal Genetic Resources and Nutrition in North China of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: .
Jin Y; Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: .
Zhao Q; State Key Laboratory of Animal Nutrition, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing 100193, China; Scientific Observing and Experiment Station of Animal Genetic Resources and Nutrition in North China of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: .
Tang C; State Key Laboratory of Animal Nutrition, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing 100193, China; Scientific Observing and Experiment Station of Animal Genetic Resources and Nutrition in North China of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: .
Li Y; Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: .
Wang H; State Key Laboratory of Animal Nutrition, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing 100193, China; Scientific Observing and Experiment Station of Animal Genetic Resources and Nutrition in North China of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: .
Qin Y; State Key Laboratory of Animal Nutrition, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing 100193, China; Scientific Observing and Experiment Station of Animal Genetic Resources and Nutrition in North China of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: .
Zhang J; State Key Laboratory of Animal Nutrition, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing 100193, China; Scientific Observing and Experiment Station of Animal Genetic Resources and Nutrition in North China of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Feb 01; Vol. 337, pp. 127767. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography, High Pressure Liquid*
Tandem Mass Spectrometry*
Egg Yolk/*chemistry
Folic Acid/*analysis
Lipids/*chemistry
Animals ; Chickens ; Dietary Supplements ; Female ; Folic Acid/isolation & purification ; Solid Phase Extraction ; Tetrahydrofolates/analysis
Czasopismo naukowe
Tytuł :
Mutational landscape screening of methylene tetrahydrofolate reductase to predict homocystinuria associated variants: An integrative computational approach.
Autorzy :
Nagarajan H; Centre for Bioinformatics, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Vision Research Foundation, Sankara Nethralaya, Chennai, 600 006, Tamil Nadu, India.
Narayanaswamy S; Department of Biotechnology, School of Bio-sciences & Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India.
Vetrivel U; Centre for Bioinformatics, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Vision Research Foundation, Sankara Nethralaya, Chennai, 600 006, Tamil Nadu, India. Electronic address: .
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Źródło :
Mutation research [Mutat Res] 2020 Jan - Apr; Vol. 819-820, pp. 111687. Date of Electronic Publication: 2020 Jan 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation, Missense*
Homocystinuria/*genetics
Methylenetetrahydrofolate Reductase (NADPH2)/*chemistry
S-Adenosylmethionine/*chemistry
Tetrahydrofolates/*chemistry
Allosteric Site ; Amino Acid Motifs ; Catalytic Domain ; Crystallography, X-Ray ; Gene Expression ; Homocystinuria/enzymology ; Homocystinuria/pathology ; Humans ; Isoenzymes/chemistry ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Machine Learning ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Methylenetetrahydrofolate Reductase (NADPH2)/metabolism ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; NADP/chemistry ; NADP/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; S-Adenosylmethionine/metabolism ; Substrate Specificity ; Tetrahydrofolates/metabolism ; Thermodynamics
Czasopismo naukowe
Tytuł :
Characterization of the first tetrameric transcription factor of the GntR superfamily with allosteric regulation from the bacterial pathogen Agrobacterium fabrum.
Autorzy :
Vigouroux A; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France.
Meyer T; Univ Lyon, Université Claude Bernard Lyon 1, CNRS, INRAE, VetAgro Sup, UMR Ecologie Microbienne, F-69622 Villeurbanne, France.
Naretto A; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France.
Legrand P; Synchrotron SOLEIL, L'Orme des Merisiers, Saint-Aubin, 91192 Gif-sur-Yvette, France.
Aumont-Nicaise M; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France.
Di Cicco A; Sorbonne Université, Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 26 rue d'Ulm, 75005 Paris, France.
Renoud S; Univ Lyon, Université Claude Bernard Lyon 1, CNRS, INRAE, VetAgro Sup, UMR Ecologie Microbienne, F-69622 Villeurbanne, France.
Doré J; Univ Lyon, Université Claude Bernard Lyon 1, CNRS, INRAE, VetAgro Sup, UMR Ecologie Microbienne, F-69622 Villeurbanne, France.
Lévy D; Sorbonne Université, Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 26 rue d'Ulm, 75005 Paris, France.
Vial L; Univ Lyon, Université Claude Bernard Lyon 1, CNRS, INRAE, VetAgro Sup, UMR Ecologie Microbienne, F-69622 Villeurbanne, France.
Lavire C; Univ Lyon, Université Claude Bernard Lyon 1, CNRS, INRAE, VetAgro Sup, UMR Ecologie Microbienne, F-69622 Villeurbanne, France.
Moréra S; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 11; Vol. 49 (1), pp. 529-546.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Multigene Family*
Agrobacterium/*metabolism
Bacterial Proteins/*physiology
Coumaric Acids/*metabolism
Repressor Proteins/*physiology
Agrobacterium/genetics ; Allosteric Regulation ; Bacterial Proteins/genetics ; Bacterial Proteins/isolation & purification ; Binding Sites ; Crystallography, X-Ray ; Gene Expression Regulation, Bacterial ; Genes, Synthetic ; Models, Molecular ; Promoter Regions, Genetic/genetics ; Protein Conformation ; Protein Domains ; Protein Multimerization ; Repressor Proteins/genetics ; Repressor Proteins/isolation & purification ; Sodium Citrate ; Tetrahydrofolates/physiology ; Zinc/physiology
SCR Organism :
Agrobacterium fabrum
Czasopismo naukowe
Tytuł :
Plasma deoxyuridine as a surrogate marker for toxicity and early clinical response in patients with metastatic colorectal cancer after 5-FU-based therapy in combination with arfolitixorin.
Autorzy :
Taflin H; Department of Surgery, The Institute of Clinical Sciences, The Sahlgrenska Academy At University of Gothenburg, Göteborg, Sweden.
Odin E; Department of Surgery, The Institute of Clinical Sciences, The Sahlgrenska Academy At University of Gothenburg, Göteborg, Sweden.
Carlsson G; Department of Surgery, The Institute of Clinical Sciences, The Sahlgrenska Academy At University of Gothenburg, Göteborg, Sweden.
Tell R; Isofol Medical AB, Göteborg, Sweden.
Gustavsson B; Department of Surgery, The Institute of Clinical Sciences, The Sahlgrenska Academy At University of Gothenburg, Göteborg, Sweden.
Wettergren Y; Department of Surgery, The Institute of Clinical Sciences, The Sahlgrenska Academy At University of Gothenburg, Göteborg, Sweden. .
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Źródło :
Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2021 Jan; Vol. 87 (1), pp. 31-41. Date of Electronic Publication: 2020 Oct 24.
Typ publikacji :
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Colorectal Neoplasms/*drug therapy
Deoxyuridine/*blood
Adult ; Age Factors ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Biomarkers/blood ; Chromatography, Liquid ; Dose-Response Relationship, Drug ; Female ; Fluorouracil/administration & dosage ; Humans ; Male ; Middle Aged ; Sex Factors ; Tandem Mass Spectrometry ; Tetrahydrofolates
Czasopismo naukowe
Tytuł :
First case report of cerebral folate deficiency caused by a novel mutation of FOLR1 gene in a Chinese patient.
Autorzy :
Zhang C; Xiangya Hospital Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P.R. China.
Deng X; Xiangya Hospital Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P.R. China.
Wen Y; XiangYa School of Medicine of Central South University, 172 Tongzipo Road, Changsha, Hunan, 410013, P.R. China.
He F; Xiangya Hospital Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P.R. China.
Yin F; Xiangya Hospital Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P.R. China.
Peng J; Xiangya Hospital Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P.R. China. .
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Źródło :
BMC medical genetics [BMC Med Genet] 2020 Nov 26; Vol. 21 (1), pp. 235. Date of Electronic Publication: 2020 Nov 26.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Encephalomalacia/*genetics
Folate Receptor 1/*genetics
Folic Acid Deficiency/*genetics
Seizures/*genetics
Status Epilepticus/*genetics
Age of Onset ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/metabolism ; Cerebral Cortex/pathology ; Child ; Encephalomalacia/cerebrospinal fluid ; Encephalomalacia/diagnostic imaging ; Encephalomalacia/drug therapy ; Folate Receptor 1/deficiency ; Folic Acid Deficiency/cerebrospinal fluid ; Folic Acid Deficiency/diagnostic imaging ; Folic Acid Deficiency/drug therapy ; Homozygote ; Humans ; Leucovorin/therapeutic use ; Magnetic Resonance Imaging ; Male ; Seizures/cerebrospinal fluid ; Seizures/diagnostic imaging ; Seizures/drug therapy ; Status Epilepticus/cerebrospinal fluid ; Status Epilepticus/diagnostic imaging ; Status Epilepticus/drug therapy ; Tetrahydrofolates/cerebrospinal fluid ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
A prospective birth cohort study on cord blood folate subtypes and risk of autism spectrum disorder.
Autorzy :
Raghavan R; Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Selhub J; Jean Mayer USDA Human Nutrition Research Center for Aging at Tufts University, Boston, MA, USA.
Paul L; Jean Mayer USDA Human Nutrition Research Center for Aging at Tufts University, Boston, MA, USA.
Ji Y; Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Wang G; Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Hong X; Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Zuckerman B; Department of Pediatrics, Boston University School of Medicine and Boston Medical Center, Boston, MA, USA.
Fallin MD; Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Wang X; Center on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.; Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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Źródło :
The American journal of clinical nutrition [Am J Clin Nutr] 2020 Nov 11; Vol. 112 (5), pp. 1304-1317.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Fetal Blood*
Autism Spectrum Disorder/*blood
Folic Acid/*blood
Folic Acid/*metabolism
Tetrahydrofolates/*blood
Cohort Studies ; Humans ; Infant, Newborn ; Odds Ratio ; Prospective Studies
Czasopismo naukowe
Tytuł :
L-Methylfolate Calcium Supplementation in Adolescents and Children: A Retrospective Analysis.
Autorzy :
Rainka M; RAINKA, ALADEEN, GENGO, CAPOTE: Dent Neurologic Institute, Amherst, NY, and State University of New York at Buffalo, Buffalo, NY WESTPHAL: Dent Neurologic Institute, Amherst, NY MEANEY and GREGER: State University of New York at Buffalo, Buffalo, NY.
Aladeen T
Westphal E
Meaney J
Gengo F
Greger J
Capote H
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Źródło :
Journal of psychiatric practice [J Psychiatr Pract] 2019 Jul; Vol. 25 (4), pp. 258-267.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Tetrahydrofolates/*therapeutic use
Adolescent ; Anticonvulsants/administration & dosage ; Anticonvulsants/therapeutic use ; Antidepressive Agents/administration & dosage ; Antidepressive Agents/therapeutic use ; Anxiety Disorders/drug therapy ; Child ; Drug Therapy, Combination ; Female ; Humans ; Male ; Mental Disorders/drug therapy ; Mood Disorders/drug therapy ; Retrospective Studies ; Tetrahydrofolates/administration & dosage ; Young Adult
Czasopismo naukowe
Tytuł :
Cerebral folate deficiency: Analytical tests and differential diagnosis.
Autorzy :
Pope S; Neurometabolic Unit, National Hospital for Neurology, London, UK.
Artuch R; Clinical Biochemistry Department, Institut de Recerca Sant Joan de Déu and CIBERER, ISCIII, Barcelona, Spain.
Heales S; Neurometabolic Unit, National Hospital for Neurology, London, UK.; Department of Chemical Pathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.; Mitochondrial Research Group, UCL Great Ormond Street Institute of Child Health, London, UK.
Rahman S; Mitochondrial Research Group, UCL Great Ormond Street Institute of Child Health, London, UK.; Department of Metabolic Medicine, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
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Źródło :
Journal of inherited metabolic disease [J Inherit Metab Dis] 2019 Jul; Vol. 42 (4), pp. 655-672. Date of Electronic Publication: 2019 May 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Brain Diseases, Metabolic, Inborn/*diagnosis
Epilepsy/*diagnosis
Folic Acid/*therapeutic use
Folic Acid Deficiency/*diagnosis
Tetrahydrofolates/*deficiency
Brain/pathology ; Brain Diseases, Metabolic, Inborn/cerebrospinal fluid ; Brain Diseases, Metabolic, Inborn/drug therapy ; Brain Diseases, Metabolic, Inborn/genetics ; Diagnosis, Differential ; Epilepsy/cerebrospinal fluid ; Epilepsy/drug therapy ; Epilepsy/genetics ; Folate Receptor 1/genetics ; Folic Acid Deficiency/cerebrospinal fluid ; Folic Acid Deficiency/drug therapy ; Folic Acid Deficiency/genetics ; Humans ; Tetrahydrofolates/cerebrospinal fluid
SCR Disease Name :
Pyridoxine-dependent epilepsy
Czasopismo naukowe

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